1,020 results on '"Knuutila S"'
Search Results
152. Potential role of a navigator gene NAV3 in colorectal cancer.
- Author
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Carlsson E, Ranki A, Sipilä L, Karenko L, Abdel-Rahman WM, Ovaska K, Siggberg L, Aapola U, Ässämäki R, Häyry V, Niiranen K, Helle M, Knuutila S, Hautaniemi S, Peltomäki P, Krohn K, Carlsson, E, Ranki, A, Sipilä, L, and Karenko, L
- Abstract
Background: The recently described navigator proteins have a multifaceted role in cytoskeletal dynamics. We report here on the relevance of one of them, navigator 3 (NAV3), in colorectal cancer (CRC).Methods: We analysed changes in chromosome 12 and NAV3 copy number in CRC/adenoma samples of 59 patients and in 6 CRC cell lines, using fluorescence in situ hybridisation, loss of heterozygosity, and array-CGH. NAV3 target genes were identified by siRNA depletion, expression arrays, and immunohistochemistry.Results: NAV3 deletion and chromosome 12 polysomy were detected in 30 and 70% of microsatellite stability (MSS) carcinomas, in 23 and 30% of adenomas and in four of six CRC cell lines. NAV3 amplification was found in 25% of MSS samples. NAV3 alterations correlated with lymph node metastasis. In normal colon cells, NAV3 silencing induced upregulation of interleukin 23 receptor (IL23R) and gonadotropin releasing hormone receptor. In MSS and microsatellite instability tumours, IL23R immunoreactivity correlated with Dukes' staging and lymph node metastases, whereas nuclear beta-catenin correlated with lymph node metastases only.Conclusion: NAV3 copy number changes are frequent in CRC and in adenomas, and upregulation of IL23R, following NAV3 silencing, strongly correlates with Dukes' staging and lymph node metastases. This suggests that NAV3 has a role in linking tissue inflammation to cancer development in the colon. [ABSTRACT FROM AUTHOR]- Published
- 2012
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153. Expression of L-myc and N-myc proto-oncogenes in human leukemias and leukemia cell lines
- Author
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Hirvonen, H, primary, Hukkanen, V, additional, Salmi, TT, additional, Makela, TP, additional, Pelliniemi, TT, additional, Knuutila, S, additional, and Alitalo, R, additional
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- 1991
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154. Trisomy 12 in chronic lymphocytic leukemia: an interphase cytogenetic study
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Losada, AP, primary, Wessman, M, additional, Tiainen, M, additional, Hopman, AH, additional, Willard, HF, additional, Sole, F, additional, Caballin, MR, additional, Woessner, S, additional, and Knuutila, S, additional
- Published
- 1991
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155. Overcoming resistance to conventional drugs in Ewing sarcoma and identification of molecular predictors of outcome.
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Scotlandi K, Remondini D, Castellani G, Manara MC, Nardi F, Cantiani L, Francesconi M, Mercuri M, Caccuri AM, Serra M, Knuutila S, and Picci P
- Published
- 2009
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156. Cytogenetic Findings and Survival in B-cell Chronic Lymphocytic Leukemia. Second IWCCLL Compilation of Data on 662 Patients
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Juliusson, Gunnar, primary, Oscier, David, additional, Juliusson, G., additional, Gahrton, G., additional, Oscier, D., additional, Fitchett, M., additional, Ross, F., additional, Brito-Babapulle, V., additional, Catovsky, D., additional, Knuutila, S., additional, Elonen, E., additional, Lechleitner, M., additional, Tanzer, J., additional, Schoenwald, M., additional, Castoldi, G. L., additional, Cuneo, A., additional, Nowell, P., additional, Peterson, L., additional, and Kay, N., additional
- Published
- 1991
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157. Malignant mesothelioma: Clinical characteristics, asbestos mineralogy and chromosomal abnormalities of 41 patients
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Tammilehto, L., primary, Tuomi, T., additional, Tiainen, M., additional, Rautonen, J., additional, Knuutila, S., additional, Pyrhönen, S., additional, and Mattson, K., additional
- Published
- 1991
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158. Trisomy 8 detection in granulomonocytic, erythrocytic and megakaryocytic lineages by CISS hybridization in a case of RARS complicating the course of PNH
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Parlier, V., primary, Tiainen, M., additional, Beris, Ph., additional, Miescher, P.A., additional, Knuutila, S., additional, and Jotterand Bellomo, M., additional
- Published
- 1991
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159. Impairment of the ubiquitin-proteasome pathway is a downstream endoplasmic reticulum stress response induced by extracellular human islet amyloid polypeptide and contributes to pancreatic beta-cell apoptosis.
- Author
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Casas S, Gomis R, Gribble FM, Altirriba J, Knuutila S, Novials A, Casas, Sílvia, Gomis, Ramon, Gribble, Fiona M, Altirriba, Jordi, Knuutila, Sakari, and Novials, Anna
- Abstract
Objective: Human islet amyloid polypeptide (hIAPP) aggregation plays a major role in the development of islet amyloidosis in type 2 diabetes. It is known that extracellular hIAPP oligomers are toxic to pancreatic beta-cells and associated with apoptosis. We therefore investigated the molecular mechanism by which extracellular hIAPP mediates pancreatic beta-cell apoptosis.Research Design and Methods: MIN6 cells and primary cultures of human pancreatic islets were treated with freshly dissolved hIAPP peptide. Morphology of the cultures was evaluated by electron microscopy. Gene expression was analyzed by microarray, RT-PCR, and immunoblot. Calcium levels were measured in fura-2-loaded cells. Apoptosis was quantified by cytometry.Results: Increased expression of several heat shock proteins and activation of the spliced form of XBP-1, a transcription factor for overexpression of chaperones during endoplasmic reticulum (ER) stress, were detected together with morphological evidence of ER dysfunction. Intracellular calcium overload was detected in association with this process. Moreover, reduction in the proteasome activity, which was detected over time, contributed to the intracellular accumulation of ubiquitinated proteins, leading to a functional suppression of the ubiquitin-proteasome pathway. In addition, impairment of the proteasome function contributed to apoptosis, while, despite the presence of hIAPP, cell viability improved when a proteasome activator was overexpressed. The key cytotoxic events induced by extracellular hIAPP were also observed in treated human islets.Conclusions: Our data suggest that ER stress responses are intracellular signaling mechanisms induced by extracellular hIAPP aggregation and that impairment of the ubiquitin-proteasome pathway is implicated in ER stress-mediated pancreatic beta-cell apoptosis. [ABSTRACT FROM AUTHOR]- Published
- 2007
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160. Favorable outcome in 20-year follow-up of children with very-low-risk ALL and minimal standard therapy, with special reference to TEL-AML1 fusion.
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Kanerva J, Saarinen-Pihkala UM, Niini T, Riikonen P, Möttönen M, Mäkipernaa A, Salmi TT, Vettenranta K, Knuutila S, Kanerva, Jukka, Saarinen-Pihkala, Ulla M, Niini, Tarja, Riikonen, Pekka, Möttönen, Merja, Mäkipernaa, Anne, Salmi, Toivo T, Vettenranta, Kim, and Knuutila, Sakari
- Published
- 2004
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161. Follow-up of Minimal Residual Disease in Pediatric Acute Myeloblastic Leukemia Using Metaphase-FISH.
- Author
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Vetteranta, K., Autio, K., Hovi, L., Knuutila, S., and Saarinen-Pihkala, U.M.
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ACUTE myeloid leukemia in children ,IN situ hybridization - Abstract
Examines the presence of minimal residual disease (MRD) among pediatric patients with acute myeloblastic leukemia (AML) during and after the cessation of therapy. Use of fluorescence in situ hybridization in determining the presence; Number of patients with detectable MRD; Establishment of clonal markers.
- Published
- 2002
162. Concomitant DNA copy number amplification at 17q and 22q in dermatofibrosarcoma protuberans.
- Author
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Kiuru-Kuhlefelt, S., El-Rifai, W., Fanburg-Smith, J., Kere, J., Miettinen, M., and Knuutila, S.
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DNA ,GENE amplification ,TUMORS ,METASTASIS ,CARCINOGENESIS ,COMPARATIVE genomic hybridization - Abstract
Dermatofibrosarcoma protuberans (DFSP) is a tumor of low or intermediate malignant potential with a tendency for recurrence, but low rate of metastasis. The tumorigenesis of DFSP has recently been shown to be associated with the fusion of the collagen type I alpha 1 (COL1A1) and platelet-derived growth factor B-chain (PDGFB) genes, often as a consequence of translocation t(17;22)(q22;q13). Cytogenetically, DFSP is often characterized by supernumerary ring chromosomes containing material from chromosomes 17 and 22. A subset of DFSPs undergo fibrosarcomatous transformation de novo or upon recurrence, and contain components indistinguishable from fibrosarcoma (FS-DFSP). The fibrosarcomatous transformation appears to carry an increased risk for recurrence and metastasis, and is considered to represent tumor progression. The molecular cytogenetic events contributing to tumor progression are unknown. We used comparative genomic hybridization to analyze DNA copy number changes in 11 cases of typical DFSP and 10 cases of FS-DFSP. All cases in both groups were found to exhibit a gain or high-level amplification on chromosome 17q and the majority also on 22q. This finding is in line with previous studies, and suggests further that not only the COL1A1/PDGFB fusion gene formation but also the role of DNA copy number gains in the 17q and 22q regions is crucial per se in the pathogenesis of DFSP. Even though FSDFSPs displayed a trend toward increase in the number of DNA copy number changes, the difference was not statistically significant, which indicates that mechanisms other than copy number changes are important in the transformation process of DFSP. [ABSTRACT FROM AUTHOR]
- Published
- 2001
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163. Requirement of CD4+ Lymphocytes in IL-2-Stimulated NK Cell Proliferation.
- Author
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Kovanen, P. E., Knuutila, S., and Timonen, T.
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KILLER cells ,CELL proliferation ,CELL cycle ,CELL growth ,LYMPHOCYTES ,CYTOKINES ,T cells - Abstract
Growth requirements of human natural killer cells in IL-2-supplemented cultures were studied. NK cell proliferation was monitored by the MAC (morphology antibody chromosomes) technique and subset specific cell cycle analysis, which both enable direct determination of cell growth in specific lymphocyte subsets among heterogeneous lymphocyte populations. Our results show that even in the presence of saturating concentrations of IL-2, the proliferative capacity of purified CD16
+ cells is quite low, but can be stimulated in a dose dependent manner by CD4+ cells. CD4+ cells could partially be replaced by IL-4 but not by various other commercially available cytokines. These results provide further evidence of the requirement of accessory stimuli in NK cell proliferation, and support the interpretation that NK cells have a direct regulatory role in specific T cell responses. [ABSTRACT FROM AUTHOR]- Published
- 1995
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164. Chromosomal abnormalities and their correlations with asbestos exposure and survival in patients with mesothelioma.
- Author
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Tiainen, M, Tammilehto, L, Rautonen, J, Tuomi, T, Mattson, K, and Knuutila, S
- Published
- 1989
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165. Two novel human B-cell lymphoma lines of lymphatic follicle origin: Cytogenetic, molecular genetic and histopathological characterisation.
- Author
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Knuutila, S., Klefström, J., Szymanska, J., Lakkala, T., Peltomäki, P., Eray, M., Teerenhovi, L., Elonen, E., Franssila, K. O., and Kaartinen, M.
- Published
- 1994
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166. Megakaryocyte colony formation by bone marrow progenitors in myelodysplasia syndromes.
- Author
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Juvonen, E., Partanen, S., Knuutila, S., and Ruutu, T.
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- 1986
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167. Heteromorphic X Chromosomes in 46,XX males?
- Author
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Chapelle, A., Simola, K., Simola, P., Knuutila, S., Gahmberg, N., Pajunen, L., Lundqvist, C., Sarna, S., and Murros, J.
- Abstract
This paper reports an attempt to determine whether the short arm of one of the X chromosomes in XX males is longer than normal. In a blind study comparing coded photomicrographs of 15 G-banded mitoses from each of five XX males and five control females, the results were ambiguous and somewhat contradictory, but gave the impression of, or were compatible with, an XXp+ phenomenon in at least two of the five XX males. Measurements of the X chromosomes from the above cells and, in addition, from 15 mitoses from each of six XXY males, failed to disclose any XXp+ phenomenon. Statistical analysis indicated that in the five XX males there was no difference in the lengths of the two Xp arms. The reasons for the apparent discrepancy between the results of ocular inspection and measurement are discussed. The putative heteromorphism might be an alteration in shape, staining intensity, or position of bands, neither of which necessarily leads to an increase in length. We conclude that our results do not indicate any XXp+ phenomenon in the five XX males tested. However, the presence or absence of XXp+ is not in itself evidence for or against interchange between the X and Y in the paternal meiosis. Our results emphasize that the etiology of XX males is likely to be heterogeneous. [ABSTRACT FROM AUTHOR]
- Published
- 1979
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168. Optimized mitogen stimulation induces proliferation of neoplastic B cells in chronic lymphocytic leukemia: significance for cytogenetic analysis.
- Author
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Larramendy, M. L., Siitonen, S. M., Zhu, Y., Hurme, M., Vilpo, L., Vilpo, J. A., and Knuutila, S.
- Subjects
STAPHYLOCOCCUS aureus ,TUMOR necrosis factors ,CHROMOSOME abnormalities ,B cell lymphoma ,INTERLEUKIN-2 ,LYMPHOCYTIC leukemia - Abstract
We tested the effects of interleukin-2 (IL-2), human recombinant tumor necrosis factor alpha (TNF-α), Staphylococcus aureus Cowan I (SAC), TPA, and their combinations, using a standard thymidine incorporation assay, in order to identify an optimal mitogen combination (OMC) for 24 consecutive patients with B-cell chronic lymphocytic leukemia (B-CLL). The combination that induced the highest thymidine incorporation was chosen as the OMC for each patient. Among 14 mitogen combinations tested, there were six different OMCs, of which the most frequent was TNF-α + IL-2. It was the OMC in 9 of 24 cases. The other OMCs were TNF-α + TPA1 (5/24), SAC + IL-2 (5/24), TPA1 + IL-2 (3/24), TPA10 + IL-2 (1/24), and TNF-α + TPA10 + IL-1 (1/24). The mitogenic power of the selected OMC in each case was then evaluated both by the combination of immunophenotyping and molecular cytogenetic techniques known as MAC (Morphology, Antibody, Chromosomes) and standard chromosome analysis. After OMC stimulation, the levels of DNA synthesis and B-cell proliferation (mitotic index) were, on average, 10-fold higher than those observed after standard TPA stimulation (P < 0.0001). The proportion of mitotic B cells exceeded the proportion of mitotic T cells in 70.1% of the cases after OMC stimulation. After TPA stimulation, 7.7% ± 2.5% of all mitoses were B-cell mitoses, whereas after OMC stimulation this proportion rose to 57.9% ± 5.3%. The frequency of clonal chromosomal aberrations increased from 46% after TPA stimulation to 79% after OMC stimulation. The clonal aberrations del(6q), del(11q), and/or del(13q) were observed in 26%, 32%, and 42% of the patients with the respective clonal chromosomal aberrations, whereas the corresponding frequencies after TPA stimulation were only 4%, 21%, and 17%. When the lineage involvement of cells with clonal chromosomal aberrations from three patients was analyzed, the aberrations were found to be restricted to B cells only, and in one patient to a minor subset of B cells. The results demonstrate that an individually chosen OMC induces a high rate of proliferation in neoplastic B cells. We found deletions in 6q, 11q, and 13q at higher frequencies than reported previously, most probably as a result of an improved mitogenic response. The identification of an optimal mitogen stimulation for each patient, prior to chromosome analysis, can well be expected to reduce the rate of false-normal results in the future. This is essential for accurate evaluation of the prognostic significance of chromosomal aberrations in B-CLL. [ABSTRACT FROM AUTHOR]
- Published
- 1998
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169. The human S-adenosylmethionine decarboxylase gene: nucleotide sequence of a pseudogene and chromosomal localization of the active gene (AMD1) and the pseudogene (AMD2).
- Author
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Maric, S.C., Crozat, A., Louhimo, J., Knuutila, S., and Jänne, O.A.
- Published
- 1995
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170. Age-associated micronuclei containing centromeres and the X chromosome in lymphocytes of women.
- Author
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Catalán, J., Autio, K., Wessman, M., Lindholm, C., Knuutila, S., Sorsa, M., and Norppa, H.
- Published
- 1995
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171. Sister chromatid differentiation and chromosomal in situ suppression hybridization: a combined methodology for analyzing cell proliferation and SCEs in individual chromosomes.
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Knuutila, S. and Larramendy, M.
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- 1992
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172. Pallister-Killian syndrome: cytogenetic and molecular studies.
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Peltomäki, P., Knuutila, S., Ritvanen, A., Kaitila, I., and Chapelle, A. DE LA
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- 1987
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173. The inheritance of fragile sites: apparent absence of fra(2)(q13) in the parents of three unrelated probands.
- Author
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Keskiaho, L, Knuutila, S, Pihko, H, Nuutila, A, Kaski, U, Koivikko, M, and de la Chapelle, A
- Abstract
We describe the inherited folate sensitive fragile site, fra(2)(q13), in three unrelated mentally retarded children, two of them with different forms of epilepsy. Fra(2)(q13) was detected in one healthy sib of one of the probands. Except for one cell in one of the fathers, fra(2)(q13) could not be detected in any of the six parents, who were repeatedly studied using methods known to induce fragile sites of this type. These findings suggest that fra(2)(q13) is not associated with the clinical features of our patients and can be transmitted by persons not expressing it. The expression of fra(2)(q13) may be age dependent. [ABSTRACT FROM PUBLISHER]
- Published
- 1987
174. MAC technique (morphology antibody chromosomes) in phenotypic identification of proliferating NK and T cells in interleukin-2-stimulated lymphocyte cultures.
- Author
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Kovanen, P. E., Timonen, T., Seppälä, I., and Knuutila, S.
- Subjects
MORPHOLOGY ,CHROMOSOMES ,T cells ,LYMPHOCYTES ,INTERLEUKIN-2 ,IMMUNOMODULATORS - Abstract
Human peripheral blood lymphocytes were activated with recombinant interleukin 2 (rIL-2) and cultured in fetal calf serum (FCS)- or human-AB-serum-supplemented media. Proliferative cells were identified by the MAC technique (morphology antibody chromosomes) which enables the immunoenzymatic identification of both mitotic and non-proliferating cells in unfractionated lymphocyte populations. The results indicate that the phenotype of more than 90% of proliferative lymphocytes can be characterized by using antibodies against T cells and NK cells. Substantial mitotic activity of CD4-positive (CD4
+ ) T cells was observed only in FCS-supplemented cultures, whereas in serum-free or human-AB-serum-supplemented cultures mostly CD8+ T cells and NK cells proliferated. The proportion of NK cells among all mitotic cells varied between 14 and 32%. Interestingly, in unfractionated cultures approximately 13% NK cells entered mitoses in the presence of rIL-2, suggesting that the poor proliferative capacity of purified NK cells demonstrated previously may be due to the lack of accessory stimulatory signals. The proliferation of B cells was minimal in all experiments. The MAC technique is a useful addition to the techniques by which lymphocyte growth regulation is monitored. [ABSTRACT FROM AUTHOR]- Published
- 1989
175. Colony formation by megakaryocyte progenitors in myelodysplatic syndromes.
- Author
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Juvonen, E., Partanen, S., Knuutila, S., and Ruutu, T.
- Published
- 1989
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176. A method combining morphological, immunocytochemical and chromosomal examinations of the same cell in the study of lymphoproliferative diseases.
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Franssila, K. O., Lindholm, C., Teerenhovi, L., and Knuutila, S.
- Published
- 1988
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177. Cytogenetic and immunologic characterization of mitotic cells in chronic lymphocytic leukaemia.
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Autio, K., Elonen, E., Teerenhovi, L., and Knuutila, S.
- Published
- 1987
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178. Correlation between bone marrow karyotype and the occurrence of erythroblast micronuclei and nuclear budding in patients with myelodysplastic syndromes.
- Author
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Teerenhovi, L., Lintula, R., Ruutu, T., and Knuutila, S.
- Published
- 1987
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179. Peripheral Blood Cells in the Study of Chromosome Aberrations of Patients with Chronic Myeloid Leukaemia or Myelofibrosis.
- Author
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Pakkala, A., Ruutu, T., Partanen, S., Kovanen, R., Borgström, G.H., and Knuutila, S.
- Published
- 1983
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180. Gain of chromosome 3 and loss of 13q are frequent alterations in pituitary adenomas
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Fan, X., Paetau, A., Aalto, Y., Valimaki, M., Sane, T., Poranen, A., Castresana, J. S., and Knuutila, S.
- Published
- 2001
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181. Changes in gene expression during progression of ovarian carcinoma
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Tapper, J., Kettunen, E., El-Rifai, W. e., Seppala, M., Andersson, L. C., and Knuutila, S.
- Published
- 2001
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182. DNA copy number profiling in esophageal Barrett adenocarcinoma
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Varis, A., Puolakkainen, P., Savolainen, H., Kokkola, A., Salo, J., Nieminen, O., Nordling, S., and Knuutila, S.
- Published
- 2001
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183. Comparative genomic hybridization reveals changes in DNA-copy number in poor-risk neuroblastoma
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Vettenranta, K., Aalto, Y., Wikstrom, S., Knuutila, S., and Saarinen-Pihkala, U.
- Published
- 2001
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184. Dedifferentiation of a well-differentiated liposarcoma to a highly malignant metastatic osteosarcoma
- Author
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Forus, A., Larramendy, M. L., Meza-Zepeda, L. A., Bjerkehagen, B., Godager, L. H., Dahlberg, A. B., Saeter, G., Knuutila, S., and Myklebost, O.
- Published
- 2001
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185. Novel findings in gene expression detected in human osteosarcoma by cDNA microarray
- Author
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Wolf, M., El-Rifai, W. e., Tarkkanen, M., Kononen, J., Serra, M., Eriksen, E. F., Elomaa, I., Kallioniemi, A., Kallioniemi, O. P., and Knuutila, S.
- Published
- 2000
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186. Comparative Genomic Hybridization Reveals Complex Genetic Changes in Primary Breast Cancer Tumors and Their Cell Lines
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Larramendy, M. L., Lushnikova, T., Bjorkqvist, A. M., Wistuba, I. I., Virmani, A. K., Shivapurkar, N., Gazdar, A. F., and Knuutila, S.
- Published
- 2000
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187. A Broad Amplification Pattern at 3q in Squamous Cell Lung Cancer-A Fluorescence In Situ Hybridization Study
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Kettunen, E., El-Rifai, W. e., Bjorkqvist, A. M., Wolff, H., Karjalainen, A., Anttila, S., Mattson, K., Husgafvel-Pursiainen, K., and Knuutila, S.
- Published
- 2000
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188. DNA Copy Number Changes and Evaluation of MYC, IGF1R, and FES Amplification in Xenografts of Pancreatic Adenocarcinoma - frequent loss of 19p13.3 and gain of 19q13.1~13.2
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Armengol, G., Knuutila, S., Llus, F., Capella, G., Miro, R., and Caballn, M.R.
- Published
- 2000
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189. Radiation-Associated Sarcomas are Characterized by Complex Karyotypes with Frequent Rearrangements of Chromosome Arm 3p - non-random distribution of base substitutions
- Author
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Mertens, F., Larramendy, M., Gustavsson, A., Gisselsson, D., Rydholm, A., Brosjo, O., Mitelman, F., Knuutila, S., and Mandahl, N.
- Published
- 2000
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190. 376 POSTER NAV3–anovel cancer biomarker
- Author
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Sipilä, L., Karenko, L., Siggberg, L., Abdel-Rahman, W., Helle, M., Häyry, V., Knuutila, S., Peltomäki, P., Ranki, A., and Krohn, K.
- Published
- 2008
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191. 35th Annual Meeting of the European Association for the Study of Diabetes
- Author
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Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Juhl, C., Pørksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th., Müller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Björn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H.-M., Oksanen, L., Tuomainen, T.-P., Kontula, K., Salonen, J. T., Dekker, J. M., de Boks, P., de Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D’Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., MacAlpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M., Kozáková, H., Kaas, A., Kofronová, O., Tlaskalová-Hogenová, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sørensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Haskó, G., Szabó, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Van Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. 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C., Kaya, F., Süsleyici, B., Öztürk, M., Eisner, M., Guldbakke, B., Karpenko, N., Brizgalova, G., Alesina, M., Røder, M. E., Schwartz, R. S., Prigeon, R., Kahn, S. E., Kendereški, A., Micić, D., Šumarac, M., Macut, Dj., Zonć, S., Čolić, M., Cvijović, G., Gligorović, P., Courtney, C. H., Atkinson, A. B., Ennis, C., Sheridan, B., Bell, P. M., Jolly, M., Amin, R., Godsland, I., Horvoka, R., Anyaoku, V., Lawrence, N., Krasova, N., Sergienko, L., Mingrone, G., Plat, L., Balasse, E. O., Zykova, T., Jenssen, T., Strelkova, A., Zykova, S., Tipisova, E., Féry, F., Wijenaike, A. N., Watt, P. W., Jung, R. T., Bolton-Smith, C., Rennie, M. J., Ludvik, B., Aigmueller, Th., Waldhaeusl, W., Courtois, P., Bource, F., Guenat, E., Philippe, J., Jéquier, E., Tappy, L., Benny, Santosa, Grönemeyer, Dietrich, Aygen, Sitke, Scholz, Nicole, Busch, Martin, Tauveron, I., Rochon, C., Dejax, C., Benoit, P., Capitan, P., Bayle, G., Prugnaud, J., Fabricio, A., Champredon, C., Thieblot, P., Grizard, J., Nielsen, M. F., Nyholm, B., Chandramouli, V., Schumann, W. C., Landau, B. R., Rizza, R. A., Mitrakou, A., Meyer, C., Tolias, A., Platanisiotis, D., Vlachos, L., Gerich, J., Wajngot, A., Sprangers, F., Jellema, W. T., Lopuhaä, C. E., van Lieshout, J. J., van der Zee, J. S., Mithieux, G., Croset, M., Zitoun, C., Hurot, J. M., Rajas, F., Montano, S., Willem, R., Verbruggen, I., Grue-Sørensen, G., Björkling, F., Watson, N. D., Burns, S. P., Murphy, H. C., Iles, R. A., Cohen, R. D., Rooney, K., Swan, V., Phuyal, J., Millar, J., Bryson, J., Denyer, G., Caterson, I., Thompson, C., Gaster, M., Handberg, Aa., Schrøder, H. D., Alzaid, A., Sobki, S., Thye-Rønn, P., Alford, F., Christopher, M., Gras, F., Brunmair, B., Neschen, S., Py, G., Lambert, K., Raynaud, E., Mercier, J., Tsuchihashi, K., Sumida, Y., Fujimoto, H., Nakamura, M., Miyata, E., Furuta, M., Katsuki, A., Ito, K., Sasaki, R., Hori, Y., Yano, Y., Adachi, Y., Lauritz, J., Eriksson, J. W., Burén, J., Zhao, L. J., Li, Z.-C., Kullin, M., Karlsson, F. A., Redondo, A., Puente, J., Clemente, F., González, N., Moberg, E., Amer, P., Hagström-Toft, E., Bolinder, J., Björnholm, M., Krook, A., Galuska, D., Myers, M., Zierath, J. R., Wallberg-Henriksson, H., Niklasson, M., Strindberg, L., Sternberg, F., Hebeda, S., Kratzer, W., Salgado, M. I., Hoss, U., Kalatz, B., Lohmann, S., Fussgänger, R., Khomazjuk, A. I., Ncscheret, A. P., Gonchar, I. V., Quinones-Galvan, A., Sironi, A. M., Cominacini, L., Nagai, Y., Yamashita, H., Takamura, T., Kobayashi, K., Szanto, I., Peth, J. A., Kinnick, T. R., Youngblood, E. B., Tritschler, H. J., Henriksen, E. J., Gašperíková, D., Rufo, C., Teran-Garcia, M., Nakamura, M. T., Clarke, S. D., Pye, S., Zhang, Z., Radziuk, J., Guignot, L., Bell, K. S., Lim-Fraser, M., Cooney, G., Kraegen, E. W., Takayama, S., Legare, D. J., Macedo, M. P., Lautt, W. W., Bradley, B., Barron, P., Davies, J., Ader, M., Richey, J. M., Ait El Mkadem, S., Macari, F., Renard, E., Méchaly, I., Brun, J. F., Cros, G., Bringer, J., del Aguila, L. F., Krishnan, R. K., Farrell, P. A., Ulbrecht, J., Correll, P. H., Kirwan, J. P., Mei, J., Rahn-Landström, T., Brindley, D., Manganiello, V., Degerman, E., Ziv, E., Shafrir, E., Kaiman, R., Galer, S., Bar-On, H., Gerő, L., Földes, K., Janssen, J., Járay, J., Perner, F., Haap, M., Houdali, B., Schmit, M. B., Dietze, G. J., Perrini, S., Natalicchio, A., Montrone, C., de Robertis, O., De Pergola, G., Strack, V., Kellerer, M., Kausch, C., Condorelli, G., Beguinot, F., Häring, H.-U., Song, X. M., Chibalin, A. V., Ryder, J. W., Jiang, X. J., Alessi, D. R., Hennige, A. M., Metzinger, E., Seipke, G., Trüb, T., Hey, A., Sørensen, A. R., Schäffer, L., Drejer, K., Kurtzhals, P., Hansen, B. F., Matozaki, T., Noguchi, T., Yamao, T., Takada, T., Ochi, F., Takeda, H., Inagaki, K., Hosoka, T., Kasuga, M., Schürt, M., Meier, M., Drenckhan, M., Meyer, M., Aries, S. P., Klein, H. H., Telting, D., van der Zon, G. C. M., Dorrestijn, J., Maassen, J. A., Clapham, J. C., Holder, J. C., Tomlinson, K. M., Pickavance, L., Buckingham, R., Wilding, J., Jacinto, S. M., Harrold, J., Ljung, B., Kjellstedt, A., Thalén, P., Widdowson, P., Williams, G., Oakes, N., Aoki, K., Saito, T., Satoh, S., Mukasa, K., Kaneshiro, M., Kawasaki, S., Hoshino, K., Okamura, A., Sekihara, H., Smith, U., Johansson, A., Nilsson, E., Olausson, T., Nakazawa, T., Suzuki, M., Martinez, J., Murado, P., Azal, Ö., Yönem, A., Çakır, B., Polat, Z., Kutlu, M., Çorakçı, A., Bayraktar, M., Gürlek, A., Koray, Z., Damian, M. S., Linn, T., Laube, H., Arzner, S., Meißner, H.-P., Giunti, S., Comune, M., Cassader, M., Conte, M. R., Sacchi, C., Musso, G., Mecca, F., Depetris, N., Gambino, R., Perin, P. Cavallo, Kawakami, S., Sandqvist, M., Jansson, P.-A., Šindelka, G., Widimský, J., Haas, T., Prázný, M., Mari, A., Nolan, J. J., Uusitupa, M. I. J., Karşıdağ, K., Hacıhanefioğlu, B., Dinççağ, N., Drivsholm, T., Palacios, R. T., Vølund, A., Pedersen, Oluf B., Letiexhe, M. R., Scheen, A. J., Quiñones Galvan, A., Simeoni, M., Basu, A., Uosukainen, A., Mäkimattila, S., Schlenzka, A., Adler, A. I., Levy, J., Stevens, R., Matthews, D., Holman, R., Boland, B. J., Jeanjean, M., Hermans, M. P., Maudoigt, C., Tonglet, R., Robert, A., Quiñones-Galvan, A., Cini, G., Galetta, F., Sanna, G., Gernone, F., Janssen, M. J., Gonera, R. K., Wolffenbuttel, B. H. R., de Leeuw, P. W., Schaper, N. C., Molęda, P., Kuczerowski, R., Czech, A., Tatoń, J., Taddei, S., Patiag, D., Qu, X., Wilkes, M., Gray, S., Seale, J. P., Donnelly, R., Campión, J., Maestro, B., Dávila, N., Carranza, M. C., Calle, C., Hales, C. N., Fernández-Real, J. M., Grasa, M., Pugeat, M., Barret, C., Ricart, W., Lindmark, S., Olsson, T., Tufvesson, M., Loeblein, K., Mehnert, B., Haering, H. U., Rave, Klaus, Heise, Tim, Clauson, Per, Hirschberger, Sabine, Heinemann, Lutz, Claret, M., Nadal, B., Truc, A., Rossi, L., Hildebrand, P., Ketterer, S., Beglinger, C., Keller, U., Gyr, K., Parvin, S., Overkamp, D., Vayreda, M., González-Huix, F., G-Huix, F., Zavaroni, I., Gasparini, P., Massironi, P., Zuccarelli, A., Delsignore, R., Reaven, G. M., Sheu, W. H. H., Lee, W. J., Chen, Y.-T., Iraklianou, S., Tournis, S., Volonakis, I., Spylopoulou, M., Bilianou, E., Melidonis, A., Foussas, S., Güler, Serdar, çakir, Bekir, Demi̇rbaş, Berrin, Gürsoy, Gül, Serter, Rüştü, Aral, Yalçin, Morton, G., Lee, S., Fahey, R., de Silva, A., Cai, X. J., Buckingham, R. E., Arch, J. R. S., Wilson, S., Clausen, J. T., Kristensen, P., Nielsen, P. F., Wulff, B. S., Thim, L., Holness, M. J., Sugden, M. C., Fryer, L. G. D., Munns, M. J., Mannucci, E., Ognibene, A., Cremasco, F., Bardini, G., Mencucci, A., Ciani, S., Pierazzuoli, E., Tsuchihashil, K., Rigalleau, V., Delafaye, C., Baillet, L., Vergnot, V., Brunou, P., Gatta, B., Gin, H., Felber, J. P., Munger, R., Assimacopoulos, F., Bobbioni, E., Golay, A., Wilken, M., Larsen, F. S., Buckley, D., Molina, L. M., Marquez, L., Arbeo, A., Hernandez, C., Kofod, H., Damholt, A. B., Buchan, A., Márquez, L., Luque, M. A., Sarti, L., Sutton, P. J., Behle, K., Heimesaat, M. M., Hüfner, M., Gravholt, Claus Højbjerg, Mølier, Niels, Christiansen, Jens Sandahl, Schmitz, Ole, Deacon, C. F., Brock, B., Knudsen, L. B., Agersø, H., Huusfeldt, P. O., Kelly, C. M. N., Brunn, C., Schioos, J., Sewing, S., Lemansky, P., Wawro, S., Mest, H. J., Taguchi, T., Motoshima, H., Yoshizato, K., Guenifi, Amel, Henriksson, M., Johansson, J., Shafqat, J., Tally, M., Wahren, J., Jömvall, H., Ekberg, K., Rigler, R., Pramanik, A., Kratz, G., Johansson, B.-L., Uhlén, M., Jörnvall, H., Forst, T., Dufayet De La Tour, D., Kunt, T., Pfützner, A., Goitom, K., Pohlmann, T., Schneider, S., Johansson, B. L., Löbig, M., Engelbach, M., Beyer, J., Ekman, Bertil, Nyström, Fredrik, Arnqvist, Hans J., Halvatsiotis, P. G., Meek, S., Bigelow, M., Nair, K. S., Maghsoudi, S., Fisker, S., Vølund, A. A., Jörgensen, J. O. L., Christiansen, J. S., Hilsted, J., Mazerkina, N. A., Tiulpakov, A. N., Gorelyshev, S. K., Peterkova, V. A., Macut, D. J., Dieguez, C., Casanueva, F. F., Catalina, P. F., Mallo, F., Andrade, A., García-Mayor, R. V. G., Popova, V. V., ter Maaten, J. C., Popp-Snijders, C., Madsen, L., Ukropec, J., Bergene, E., Rnstan, A. C., Berge, R., Arner, P., Wahl, G., Häring, H., Bryson, J. M., Curtis, S. E., Caterson, I. D., Winzell, M. Sörhede, Svensson, H., Ahnén, B., Holm, C., Phillips, C., Madigan, C., Owens, D., Collins, P., Johnson, A., Tomkin, G. H., Cabezas, M. Castro, van Oostrom, A. J. H. H. M., Erkelens, D. W., Summers, L. K. M., Fielding, B. A., Ilic, V., Clark, M. L., Frayn, K. N., Pietzsch, J., Julius, U., Nitzsche, S., Fischer, S., Lindgren, C., Amrot-Fors, L., Hoffmann, M. M., Luft, D., Schmülling, R.-M., D’Adamo, M., Leonetti, F., Paoloni, A., Ribaudo, M. C., Basso, M. S., Elmore, U., Restuccia, A., Sbraccia, P., Emilsson, V., O’Dowd, J., Heyman, R., Cawthorne, M. A., Pelikánová, T., Kazdová, L., Žák, A., Chvojková, Š., Özer, E. M., Kadıoğlu, P., Korugan, Ü., Hatemi, H., Rivellese, A. A., Dullaart, R. P. F., Riemens, S. C., Sluiter, W. J., van Tol, A., Farnier, M., Megnien, S., Turpin, G., Stulp, B. K., Brambilla, P., Brunelli, A., Riva, M. C., Manzoni, P., de Poli, S., Riboni, S., Stolk, R. P., Meijer, R., Wink, O., Zelissen, P. M. J., van Gils, A. P. G., Grobbee, D. 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W., Taverna, M., Guerre-Millo, M., Chevalier, A., Pacher, N., Slama, G., Gorshunska, M., Buyken, A. E., Heitkamp, G., Kabir, M., Oppert, J. M., Wursch, P., Bruzzo, F., Rahman, M. H., Fatima, K., Ahmed, S., Mondal, H. N., Yilmaz, M., Öztok, U., Karakoç, A., Çakır, N., Düzgün, E., Yetkin, İ., Arslan, M., Şardaş, S., Wilding, John, Géloën, A., Baret, G., Dalmaz, Y., Peyronnet, J., Clémenceau, B., Martignat, L., Lalain, S., Gouin, E., Kenda-Ropson, N., Miller, A. O. A., You, S., Aguilera, E., Recasens, M., Flores, L., Ricart, M. J., Fernández-Cruz, L., Esmatjes, E., Crenier, L., Noël, C., Le Moine, A., Mahy, M., Danguy, A., Kiss, R., Goldman, M., Bracci, C., De Haan, B., Nilsson, K., Deschamps, J. Y., Glagoličová, A., Smrčková, I., Dieterle, C., Illner, W. D., Land, W., Feldmeier, H., Scheuer, R., Lalli, C., Di Loreto, C., Ellringmann, U., Balks, H. J., v. zur Mühlen, A., Dengler, R., Weissenborn, K., Rasmussen, B. M., Ørskov, L., Watson, J., Owen, G., Barrett, G., Ingleby, J., Weiss, M., Deary, I., Cavan, D., Kerr, D., Bruneiii, A., Cuce’, A., Elsing, H. G., Kühne, D., Quinn, N. D., Warner, D. P., Buysschaert, M., Jamal, R., O’Brien, T., Latare, P., Mullen, J., Rein, A., Wargo, M., Parkes, J. L., Ginsberg, B., Sotiropoulos, A., Peppas, Th. A., Kotsini, V., Apostolou, O., Bousboulas, S., Michailidis, E., Sawala, M., Pappas, S., Nilsson, P. M., Nilsson, J. Å., Berglund, G., Molins, T., Esteban, J. I., Genescà, J., Paris, I., Haufroid, V., Selvais, Ph., Petit, J. M., Duong, M., Grappin, M., Guiguet, M., Rudoni, S., Portier, H., Brun, J. M., Bagg, W., Plank, L., Drury, P. L., Sharpe, N., Braatvedt, G. D., Carrascosa, J. M., Molero, J. C., Fermίn, Y., Andrés, A., Satrústegui, J., Rietzsch, H., Patzak, A., Schwanebeck, U., Simpson, H., Robertson-Mackay, F., Montegriffo, E., Fox, C., Chiasson, J.-L., Josse, R. G., Dorman, J. M., Gerstein, H. C., Lau, D., Leiter, L. A., Maheux, P., Meneilly, G. S., Murphy, L., Rodger, N. W., Ross, S. A., Ryan, E., Yale, J.-F., Wolever, T. M. S., Haller, T., Elias, I., Segal, P., Standi, E., Rybka, J., Sencer, E., Satman, I., Schlcnzka, A., Vakkilainen, J., Tsaglis, H., Ioannidis, I., Giakoumaki, A., Amantou, A., Komitopoulos, N., Georgiou, S., Varsamis, E., Katsilambros, N., El Gayar, M., Shereba, N., Botros, R., Fikry, R., Jackson, D., Balme, M., Silva-Nunes, J., Alves, J., Bogalho, P., Gardete-Correia, L., Nunes-Corrêa, J., Kot’átková, A., Němcová, D., Vrbíková, J., Zamrazil, V., Meyer, L., Delbachian, I., Lehert, P., Cugnardey, N., Drouin, P., Guerci, B., Wagner, O. F., Jones, N. P., Vallance, S. E., Thompson, K. A., Miller, A. K., Inglis, A. M. L., Patterson, S., Jorkasky, D., Freed, M. I., Mathisen, A. L., Schneider, R., Rubin, C., Houser, V., Beebe, K. L., Kortboyer, J. M., Eckland, D. J. A., Cranmer, H., Mori, Y., Kurokawa, N., Komiya, H., Horikoshi, H., Yokoyama, J., Tajima, N., Ikeda, Y., Bakst, A., Hemyari, P., Lönnqvist, F., Owen, S., Vikramadithyan, R. K., Chakrabarti, R., Misra, P., Prem Kumar, M., Sunil Kumar, K. B., Ghosh, A., Rajagopalan, R., Goldstein, B., Katoh, S., Tsuruoka, N., Hata, S., Matsushima, M., Ikemoto, S., Inoue, Y., Edwards, G., Fonseca, V., Biswas, N., Bakris, G., Viberti, G., Rebuck, A. S., Weill, S., Abel, M. G., Klappoth, W., Brodesser, A., Linkeschowa, R., Pushparaj, P., Tan, C. H., Tan, B. K. H., Bahner, A., Parker, J., Waite, G., Lipson, V., Nahar, N., Rokeya, B., Parveen, S., Nur-e-Alam, M., Mosihuzzaman, M., Hansen, A. Kornerup, Lepore°, M., Kurzhals, R., Pampanelli°, S., Fanelli°, C. G., Bolli°, G. B., Ratner, R. E., Hirsch, I. B., Mecca, T. E., Wilson, C. A., Mohideen, P., Mudaliar, S., Deutsch, R., Ciaraldi, T., Armstrong, D., Kim, B., Morrill, B., Sha, X., Henry, R., Meyer, B. H., Scholtz, H. 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- 1999
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192. Clinical Importance of Genomic Imbalances in Synovial Sarcoma Evaluated by Comparative Genomic Hybridization - analysis based on 86 patients from the Scandinavian Sarcoma group register
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Skytting, B.T., Szymanska, J., Aalto, Y., Lushnikova, T., Blomqvist, C., Elomaa, I., Larsson, O., and Knuutila, S.
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- 1999
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193. DNA Copy Number Losses Are More Frequent in Primary Larynx Tumors with Lymph Node Metastases Than in Tumors without Metastases - implications for field cancerization
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Kujawski, M., Aalto, Y., Jaskula-Sztul, R., Szyfter, W., Szmeja, Z., Szyfter, K., and Knuutila, S.
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- 1999
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194. DNA Copy Number Losses at 1p32-pter in Monozygotic Twins Concordant for Breast Cancer - identification of regions of DNA amplification and deletion in common with invasive breast carcinoma
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El-Rifai, W., Tarmo, L., Hemmer, S., Forsti, A., Pedersen, N., Lichtenstein, P., Ahlbom, A., Soderberg, M., Knuutila, S., and Hemminki, K.
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- 1999
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195. P150 Expression of ZAP-70, RAF-1 and C-MYC in B-cell lymphomas and chronic leukaemia. Overexpression of ZAP70 predicts poor survival in mantle cell lymphoma
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Nagy, B., Galimberti, S., Vilpo, J., Elonen, E., Franssila, K., and Knuutila, S.
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- 2007
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196. Allogeneic stem cell transplantation reverses the poor prognosis of CML patients with deletions in derivative chromosome 9.
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Lundán, T, Volin, L, Ruutu, T, Knuutila, S, and Porkka, K
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LETTERS to the editor ,CHRONIC myeloid leukemia - Abstract
Presents a letter to the editor about the effect of allogeneic stem cell transplantation on the poor prognosis of CML patients with deletions in derivative chromosome 9.
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- 2005
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197. A Cytogenetic Study of Malignant Fibrous Histiocytoma
- Author
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Szymanska, J., Tarkkanen, M., Wiklund, T., Virolainen, M., Blomqvist, C., Asko-Seljavaara, S., Tukiainen, E., Elomaa, I., and Knuutila, S.
- Published
- 1995
- Full Text
- View/download PDF
198. A method for simultaneous study of the karyotype, morphology, and immunologic phenotype of mitotic cells in hematologic malignancies
- Author
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Teerenhovi, L, Knuutila, S, Ekblom, M, Rossi, L, Borgstrom, GH, Tallman, JK, Andersson, L, and de la Chapelle, A
- Abstract
A major problem in the cytogenetic analysis of hematologic neoplasms has been an inability to identify the cell from which the chromosomes were obtained. We describe a procedure that allows simultaneous analysis of karyotype and cell cytology in mitotic cells. The method differs from conventional cytogenetic analysis in that after mild hypotonic treatment, the cells are cytocentrifuged onto glass slides. In mitotic cells, this procedure often results in adequate spread of the chromosomes within the intact cell membrane. The cytoplasmic structure also remains intact, so that cytologic preparations are of good quality. Morphologic and immunologic identification of mitotic cells can be done using routine hematologic stains, such as Giemsa or Sudan black B, and various antisera using immunofluorescence techniques. The chromosomes can be simultaneously analyzed either without banding on slides stained with Giemsa or with Q-banding on slides stained with immunofluorescence techniques. Identification of numerical and structural karyotype aberrations thus is possible in morphologically identified cells.
- Published
- 1984
- Full Text
- View/download PDF
199. Overrepresentation of 1q21-23 and 12q13-21 in Lipoma-like Liposarcomas but Not in Benign Lipomas: A Comparative Genomic Hybridization Study
- Author
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Szymanska, J., Virolainen, M., Tarkkanen, M., Wiklund, T., Asko-Seljavaara, S., Tukiainen, E., Elomaa, I., Blomqvist, C., and Knuutila, S.
- Published
- 1997
- Full Text
- View/download PDF
200. Microsatellite Markers as Tools for Characterization of DNA Amplifications Evaluated by Comparative Genomic Hybridization
- Author
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Wolf, M., Aaltonen, L. A., Szymanska, J., Tarkkanen, M., Elomaa, I., and Knuutila, S.
- Published
- 1997
- Full Text
- View/download PDF
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