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31,952 results on '"Knott A"'

156. Deep Active Surface Models

Author

Wickramasinghe, Udaranga, Knott, Graham, and Fua, Pascal

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Graphics, Computer Science - Machine Learning
Abstract

Active Surface Models have a long history of being useful to model complex 3D surfaces but only Active Contours have been used in conjunction with deep networks, and then only to produce the data term as well as meta-parameter maps controlling them. In this paper, we advocate a much tighter integration. We introduce layers that implement them that can be integrated seamlessly into Graph Convolutional Networks to enforce sophisticated smoothness priors at an acceptable computational cost. We will show that the resulting Deep Active Surface Models outperform equivalent architectures that use traditional regularization loss terms to impose smoothness priors for 3D surface reconstruction from 2D images and for 3D volume segmentation., Comment: 11 pages, 7 figures, 6 tables

Published
2020

157. Quantum illumination with multiple entangled photons

Author

Torromé, Ricardo Gallego, Bekhti-Winkel, Nadya Ben, and Knott, Peter

Subjects
Quantum Physics
Abstract

In this work, a theoretical generalization of Lloyd's quantum illumination to signal beams described by two entangled photon states is developed. It is shown that the new protocol offers a method to find the range of the target, reduces the size of the required time-bandwidth product to have the same signal to noise ratio than in Lloyd's quantum illumination, has a lower probability of false positive and is resilient against noise and also potentially against losses. However, the generation of the required three photon states for the protocol posses a technical problem for its practical implementation not fully addressed. Recent advances in triple photon generation that can overcome this problem are discussed. Other issues related with the protocol are also considered., Comment: 14 pages; Discussion section extended; several references added. arXiv admin note: text overlap with arXiv:2006.14238

Published
2020
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158. Introduction to quantum radar

Author

Torromé, Ricardo Gallego, Bekhti-Winkel, Nadya Ben, and Knott, Peter

Subjects
Quantum Physics, Physics - Applied Physics
Abstract

After a brief introduction to the notion of quantum entanglement and quantum correlations, several schemes for a quantum radar based upon the quantum illumination and others protocols are discussed. We review different concepts that have been introduced to overcome several of the inherent difficulties in the implementation of quantum generation and/or detection quantum sensing protocols for RADAR applications. Our review is an up-to date critical presentation of the state of the art, with emphasis in the case by case assessment of the feasibility of the different concepts. We also aim that the review is accessible to non-experts in the field. Hence several appendixes and a technical glossary are included., Comment: 68 pages, no figures

Published
2020

159. Quantum sensing networks for the estimation of linear functions

Author

Rubio, Jesús, Knott, Paul A, Proctor, Timothy J, and Dunningham, Jacob A

Subjects
Quantum Physics
Abstract

The theoretical framework for networked quantum sensing has been developed to a great extent in the past few years, but there are still a number of open questions. Among these, a problem of great significance, both fundamentally and for constructing efficient sensing networks, is that of the role of inter-sensor correlations in the simultaneous estimation of multiple linear functions, where the latter are taken over a collection local parameters and can thus be seen as global properties. In this work we provide a solution to this when each node is a qubit and the state of the network is sensor-symmetric. First we derive a general expression linking the amount of inter-sensor correlations and the geometry of the vectors associated with the functions, such that the asymptotic error is optimal. Using this we show that if the vectors are clustered around two special subspaces, then the optimum is achieved when the correlation strength approaches its extreme values, while there is a monotonic transition between such extremes for any other geometry. Furthermore, we demonstrate that entanglement can be detrimental for estimating non-trivial global properties, and that sometimes it is in fact irrelevant. Finally, we perform a non-asymptotic analysis of these results using a Bayesian approach, finding that the amount of correlations needed to enhance the precision crucially depends on the number of measurement data. Our results will serve as a basis to investigate how to harness correlations in networks of quantum sensors operating both in and out of the asymptotic regime., Comment: 31 pages, 5 figures, 1 table. Minor revision. It incorporates parts of the material in chapter 6 of arXiv:1912.02324

Published
2020
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160. Secure multiparty computations in floating-point arithmetic

Author

Guo, Chuan, Hannun, Awni, Knott, Brian, van der Maaten, Laurens, Tygert, Mark, and Zhu, Ruiyu

Subjects
Computer Science - Cryptography and Security, Computer Science - Information Theory, Computer Science - Machine Learning, Mathematics - Numerical Analysis, Statistics - Computation
Abstract

Secure multiparty computations enable the distribution of so-called shares of sensitive data to multiple parties such that the multiple parties can effectively process the data while being unable to glean much information about the data (at least not without collusion among all parties to put back together all the shares). Thus, the parties may conspire to send all their processed results to a trusted third party (perhaps the data provider) at the conclusion of the computations, with only the trusted third party being able to view the final results. Secure multiparty computations for privacy-preserving machine-learning turn out to be possible using solely standard floating-point arithmetic, at least with a carefully controlled leakage of information less than the loss of accuracy due to roundoff, all backed by rigorous mathematical proofs of worst-case bounds on information loss and numerical stability in finite-precision arithmetic. Numerical examples illustrate the high performance attained on commodity off-the-shelf hardware for generalized linear models, including ordinary linear least-squares regression, binary and multinomial logistic regression, probit regression, and Poisson regression., Comment: 31 pages, 13 figures, 6 tables

Published
2020

163. Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study

Author

Reindl, Caroline, Walther, Katrin, Allgäuer, Anna-Lena, Lang, Johannes D., Welte, Tamara M., Stritzelberger, Jenny, Gollwitzer, Stephanie, Schwarz, Michael, Trollmann, Regina, Madzar, Dominik, Knott, Michael, Doerfler, Arnd, Seifert, Frank, Rössler, Karl, Brandner, Sebastian, Rampp, Stefan, Schwab, Stefan, and Hamer, Hajo M.

Published
2023
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164. Dynamics of CLIMP-63 S-acylation control ER morphology

Author

Sandoz, Patrick A., Denhardt-Eriksson, Robin A., Abrami, Laurence, Abriata, Luciano A., Spreemann, Gard, Maclachlan, Catherine, Ho, Sylvia, Kunz, Béatrice, Hess, Kathryn, Knott, Graham, S. Mesquita, Francisco, Hatzimanikatis, Vassily, and van der Goot, F. Gisou

Published
2023
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168. Kinetic analysis of Cas12a and Cas13a RNA-Guided nucleases for development of improved CRISPR-Based diagnostics

Author

Nalefski, Eric A, Patel, Nidhi, Leung, Philip JY, Islam, Zeba, Kooistra, Remy M, Parikh, Ishira, Marion, Estelle, Knott, Gavin J, Doudna, Jennifer A, Le Ny, Anne-Laure M, and Madan, Damian

Subjects
Biological Sciences, Bioinformatics and Computational Biology, Emerging Infectious Diseases, Genetics, Infectious Diseases, Infection, Good Health and Well Being, Biochemistry, Chemical reaction kinetics, Molecular biology
Abstract

Bacterial CRISPR systems provide acquired immunity against invading nucleic acids by activating RNA-programmable RNases and DNases. Cas13a and Cas12a enzymes bound to CRISPR RNA (crRNA) recognize specific nucleic acid targets, initiating cleavage of the targets as well as non-target (trans) nucleic acids. Here, we examine the kinetics of single-turnover target and multi-turnover trans-nuclease activities of both enzymes. High-turnover, non-specific Cas13a trans-RNase activity is coupled to rapid binding of target RNA. By contrast, low-turnover Cas12a trans-nuclease activity is coupled to relatively slow cleavage of target DNA, selective for DNA over RNA, indifferent to base identity, and preferential for single-stranded substrates. Combining multiple crRNA increases detection sensitivity of targets, an approach we use to quantify pathogen DNA in samples from patients suspected of Buruli ulcer disease. Results reveal that these enzymes are kinetically adapted to play distinct roles in bacterial adaptive immunity and show how kinetic analysis can be applied to CRISPR-based diagnostics.

Published
2021

169. Accelerated RNA detection using tandem CRISPR nucleases.

Author

Liu, Tina Y, Knott, Gavin J, Smock, Dylan CJ, Desmarais, John J, Son, Sungmin, Bhuiya, Abdul, Jakhanwal, Shrutee, Prywes, Noam, Agrawal, Shreeya, Díaz de León Derby, María, Switz, Neil A, Armstrong, Maxim, Harris, Andrew R, Charles, Emeric J, Thornton, Brittney W, Fozouni, Parinaz, Shu, Jeffrey, Stephens, Stephanie I, Kumar, G Renuka, Zhao, Chunyu, Mok, Amanda, Iavarone, Anthony T, Escajeda, Arturo M, McIntosh, Roger, Kim, Shineui, Dugan, Eli J, IGI Testing Consortium, Pollard, Katherine S, Tan, Ming X, Ott, Melanie, Fletcher, Daniel A, Lareau, Liana F, Hsu, Patrick D, Savage, David F, and Doudna, Jennifer A

Subjects
IGI Testing Consortium, Humans, RNA, Viral, Reverse Transcriptase Polymerase Chain Reaction, CRISPR-Cas Systems, COVID-19, SARS-CoV-2, Lung, Biodefense, Emerging Infectious Diseases, Vaccine Related, Prevention, Infectious Diseases, 4.1 Discovery and preclinical testing of markers and technologies, Infection, Biochemistry & Molecular Biology, Medicinal and Biomolecular Chemistry, Biochemistry and Cell Biology
Abstract

Direct, amplification-free detection of RNA has the potential to transform molecular diagnostics by enabling simple on-site analysis of human or environmental samples. CRISPR-Cas nucleases offer programmable RNA-guided RNA recognition that triggers cleavage and release of a fluorescent reporter molecule, but long reaction times hamper their detection sensitivity and speed. Here, we show that unrelated CRISPR nucleases can be deployed in tandem to provide both direct RNA sensing and rapid signal generation, thus enabling robust detection of ~30 molecules per µl of RNA in 20 min. Combining RNA-guided Cas13 and Csm6 with a chemically stabilized activator creates a one-step assay that can detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA extracted from respiratory swab samples with quantitative reverse transcriptase PCR (qRT-PCR)-derived cycle threshold (Ct) values up to 33, using a compact detector. This Fast Integrated Nuclease Detection In Tandem (FIND-IT) approach enables sensitive, direct RNA detection in a format that is amenable to point-of-care infection diagnosis as well as to a wide range of other diagnostic or research applications.

Published
2021

170. Designed for the camera : Irish interior makeover television, 1996-2014

Author

Knott, Neville, Sparke, Penny, and Fisher, Fiona

Subjects
interior design, makeover television, amature and professional, knowledge and entertainment, transformed interior, television production processes, interior design processes, history of Irish interior design
Abstract

This thesis examines how television makeover programmes, broadcast in Ireland between 1996 and 2014, mediate the professional practice of interior design. It argues that the programme-makers, in seeking to engage viewers, used a series of strategies-notably the suppression of professional and educational knowledge about interior design-to convey an image of staged coherence that was arrived at unproblematically. In that process, it will be argued, interior design knowledge got lost, and entertainment triumphed. Focusing on these strategies, the thesis considers how the production process used interior design, nonetheless, to attract an audience and generate ratings, focusing on the relationship between amateurs and professionals, the visual construction of televised interiors, and the blurred boundaries between education and entertainment. It sets this analysis within the context of external socio-economic factors. Drawing on two thousand hours of Irish television content, the thesis investigates televisual practices and examines the changes that occurred within Irish makeover programmes between 1996 and 2014. Most importantly, it aims to extend the current understanding of the tele-visualised interior by approaching it from a production perspective. To achieve its aims, the research has drawn on both the processes of interior design and television-making, and importantly, their intersection.

Published
2021

171. Cisgenderism in sports talk : a discursive analysis

Author

Knott-Fayle, Gabriel

Subjects
cisgenderism, transgender, discursive psychology, Sports communication, prejudice
Abstract

In this thesis, I contribute to the growing understanding of cisgenderism by examining its expressing in the context of sports media and sports talk. Whilst there is an expanding amount of literature on cisgenderism, little work has thus far offered a detailed analysis of its manifestation in situated contexts and even less so in relation to sports. This is a notable gap because sport is typically rife with structural forms of trans-discrimination. In fact, sport remains a particularly strong bastion of binary sex/gender enforcement, even as other areas of society have begun to contest such dimorphic understandings. Furthermore, as a mediated spectacle, very little if anything comes close to matching the viewing figures and cultural impact of major sporting events. This being the case, the way that trans sportspeople and trans sporting inclusion are talked about reveals a lot about how cisgenderism functions and how normative sex and gender identities are relationally produced and positioned. It is this functioning of cisgenderism, expressed in language, that I unpack in this thesis. In so doing, I will build on established conceptions of cisgenderism and trans-discrimination, to develop an understanding of how it is discursively and rhetorically (re)produced and expressed in a situated context. In particular, I examine the representation of trans sportswomen as the vast majority of sporting discourse on the topic focuses securing on the women's sporting category. Drawing on a wide range of discursive data throughout including sports media (newspapers, television, online media and social media) as well as focus group and interview data, I build on discursive psychological concepts to develop an understanding of how identities and the world are constructed and positioned in sports talk about trans-inclusion. Furthermore, I apply discursive psychological understandings of prejudice to my analysis of how cisgenderism is expressed. I also utilise reflexive thematic analysis and feminist reflexive methods to develop my critique. Primarily my findings explore the ways that cisgenderist activities are instantiated in sports talk through well-established sporting discursive resources such as anxieties around cheating and fairness, sexism, a distrust of Eastern and developing world athletic successes, sex and gender testing, and highly medicalised understandings of the body. In addition, my examination builds on the concept of the "hybrid media system" (Chadwick, 2013) to consider how cisgenderism is produced across and between different parts of the highly multimediated system of sports media. Fundamentally, my findings relate to the way that, in line with other discursive psychological understandings of prejudice, cisgenderism functions in "banal" (Billig, 1995) or "mundane" (Peel, 2001; Riggs, 2014) ways.

Published
2021
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172. Geotechnical asset management for climate change risk

Author

Corker-Knott, Alexandra L.

Subjects
TA Engineering (General). Civil engineering (General), TE Highway engineering. Roads and pavements
Abstract

Geotechnical asset management is a process and tool which encourages robust data management, optimised programming and evidenced based decision-making. Although asset management has come a long way since becoming a more accepted practice in the highways sector , and has fundamentally changed the way that assets are maintained, there are aspects that are still evolving as clarity on asset and network need improves and extends into future years. However, in gaining more sight into the future of asset networks, unforeseen risks begin to appear. These risks may not have been known or well understood at the time the asset network was constructed, or may not have been an issue when the asset was originally designed, yet, over the years the changing use of the asset network by users has led to new risks becoming apparent. One of these historically unknown risks is climate change. While knowledge about how climate change is expected to impact assets is improving, the understanding of the scale and scope of assets that will be affected by climate change is less well developed. The tool presented in this research is a risk assessment, which evaluates the risk profile of the effects of climate change on a geotechnical asset as the result of the critical condition impact factors. This risk profile is completed by a scoring the impacting factors on a scorecard, for subsequent inclusion in the final risk score. The likelihood element of the risk assessment uses probability scores taken from the medium emission scenarios presented by the UKCIP 2018. The resultant risk score can then be utilised as a forward planning tool for maintenance, or increased monitoring, where appropriate. Three case studies were assessed to show the practical application of the system. The results of the case studies show that the process works and produces results which aid the planning of maintenance to mitigate for climate change.

Published
2021

174. Hepatic Steatosis is Negatively Associated with Bone Mineral Density in Children

Author

Chun, Lauren F, Yu, Elizabeth L, Sawh, Mary Catherine, Bross, Craig, Nichols, Jeanne, Polgreen, Lynda, Knott, Cynthia, Schlein, Alexandra, Sirlin, Claude B, Middleton, Michael S, Kado, Deborah M, and Schwimmer, Jeffrey B

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Complementary and Integrative Health, Digestive Diseases, Clinical Research, Pediatric, Osteoporosis, Nutrition, Chronic Liver Disease and Cirrhosis, Biomedical Imaging, Liver Disease, 2.1 Biological and endogenous factors, Aetiology, Musculoskeletal, Absorptiometry, Photon, Adolescent, Alanine Transaminase, Bone Density, Child, Female, Humans, Liver, Magnetic Resonance Imaging, Male, Non-alcoholic Fatty Liver Disease, Sampling Studies, Vitamin D, gamma-Glutamyltransferase, MRI-PDFF, NAFLD, osteopenia, osteoporosis, pediatric, vitamin D, Human Movement and Sports Sciences, Paediatrics and Reproductive Medicine, Pediatrics, Paediatrics
Abstract

ObjectiveTo evaluate the relationship between hepatic steatosis and bone mineral density (BMD) in children. In addition, to assess 25-hydroxyvitamin D levels in the relationship between hepatic steatosis and BMD.Study designA community-based sample of 235 children was assessed for hepatic steatosis, BMD, and serum 25-hydroxyvitamin D. Hepatic steatosis was measured by liver magnetic resonance imaging proton density fat fraction (MRI-PDFF). BMD was measured by whole-body dual-energy x-ray absorptiometry.ResultsThe mean age of the study population was 12.5 years (SD 2.5 years). Liver MRI-PDFF ranged from 1.1% to 40.1% with a mean of 9.3% (SD 8.5%). Across this broad spectrum of hepatic fat content, there was a significant negative relationship between liver MRI-PDFF and BMD z score (R = -0.421, P

Published
2021

175. Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

Author

Krall, Abigail S, Mullen, Peter J, Surjono, Felicia, Momcilovic, Milica, Schmid, Ernst W, Halbrook, Christopher J, Thambundit, Apisadaporn, Mittelman, Steven D, Lyssiotis, Costas A, Shackelford, David B, Knott, Simon RV, and Christofk, Heather R

Subjects
Cancer, Activating Transcription Factor 4, Animals, Asparagine, Aspartic Acid, Cell Line, Tumor, Cell Proliferation, Diet, Electron Transport Chain Complex Proteins, Humans, Mechanistic Target of Rapamycin Complex 1, Metformin, Mice, Mice, Inbred NOD, Mitochondria, Neoplasms, Nucleotides, Survival Rate, asparaginase, asparagine, cancer metabolism, cancer treatment, dietary restriction, metformin, respiration, Biochemistry and Cell Biology, Medical Biochemistry and Metabolomics, Endocrinology & Metabolism
Abstract

Mitochondrial respiration is critical for cell proliferation. In addition to producing ATP, respiration generates biosynthetic precursors, such as aspartate, an essential substrate for nucleotide synthesis. Here, we show that in addition to depleting intracellular aspartate, electron transport chain (ETC) inhibition depletes aspartate-derived asparagine, increases ATF4 levels, and impairs mTOR complex I (mTORC1) activity. Exogenous asparagine restores proliferation, ATF4 and mTORC1 activities, and mTORC1-dependent nucleotide synthesis in the context of ETC inhibition, suggesting that asparagine communicates active respiration to ATF4 and mTORC1. Finally, we show that combination of the ETC inhibitor metformin, which limits tumor asparagine synthesis, and either asparaginase or dietary asparagine restriction, which limit tumor asparagine consumption, effectively impairs tumor growth in multiple mouse models of cancer. Because environmental asparagine is sufficient to restore tumor growth in the context of respiration impairment, our findings suggest that asparagine synthesis is a fundamental purpose of tumor mitochondrial respiration, which can be harnessed for therapeutic benefit to cancer patients.

Published
2021

176. Dairy Fat Intake, Plasma Pentadecanoic Acid, and Plasma Iso‐heptadecanoic Acid Are Inversely Associated With Liver Fat in Children

Author

Sawh, Mary Catherine, Wallace, Martina, Shapiro, Emma, Goyal, Nidhi P, Newton, Kimberly P, Yu, Elizabeth L, Bross, Craig, Durelle, Janis, Knott, Cynthia, Gangoiti, Jon A, Barshop, Bruce A, Gengatharan, Jivani M, Meurs, Noah, Schlein, Alexandra, Middleton, Michael S, Sirlin, Claude B, Metallo, Christian M, and Schwimmer, Jeffrey B

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Liver Disease, Digestive Diseases, Chronic Liver Disease and Cirrhosis, Prevention, Nutrition, Pediatric, Oral and gastrointestinal, Metabolic and endocrine, Adolescent, Child, Cross-Sectional Studies, Fatty Acids, Humans, Liver, Magnetic Resonance Imaging, Non-alcoholic Fatty Liver Disease, milk, nonalcoholic steatohepatitis, nutrition, obesity, Medical and Health Sciences, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics, Paediatrics
Abstract

ObjectivesWe sought to evaluate the relevance of pediatric dairy fat recommendations for children at risk for nonalcoholic fatty liver disease (NAFLD) by studying the association between dairy fat intake and the amount of liver fat. The effects of dairy fat may be mediated by odd chain fatty acids (OCFA), such as pentadecanoic acid (C15:0), and monomethyl branched chain fatty acids (BCFA), such as iso-heptadecanoic acid (iso-C17:0). Therefore, we also evaluated the association between plasma levels of OCFA and BCFA with the amount of liver fat.MethodsObservational, cross-sectional, community-based sample of 237 children ages 8 to 17. Dairy fat intake was assessed by 3 24-hour dietary recalls. Plasma fatty acids were measured by gas chromatography-mass spectrometry. Main outcome was hepatic steatosis measured by whole liver magnetic resonance imaging proton density fat fraction (MRI-PDFF).ResultsMedian dairy fat intake was 10.6 grams/day (range 0.0--44.5 g/day). Median liver MRI-PDFF was 4.5% (range 0.9%-45.1%). Dairy fat intake was inversely correlated with liver MRI-PDFF (r = -0.162; P = .012). In multivariable log linear regression, plasma C15:0 and iso-C17:0 were inverse predictors of liver MRI-PDFF (B = -0.247, P = 0.048; and B = -0.234, P = 0.009).ConclusionsDairy fat intake, plasma C15:0, and plasma iso-C17:0 were inversely correlated with hepatic steatosis in children. These hypothesis-generating findings should be tested through clinical trials to better inform dietary guidelines.

Published
2021

177. Regional Practice Variation and Outcomes in the Standard Versus Accelerated Initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) Trial: A Post Hoc Secondary Analysis

Author

Vaara, Suvi T., Serpa Neto, Ary, Bellomo, Rinaldo, Adhikari, Neill K. J., Dreyfuss, Didier, Gallagher, Martin, Gaudry, Stephane, Hoste, Eric, Joannidis, Michael, Pettilä, Ville, Wang, Amanda Y., Kashani, Kianoush, Wald, Ron, Bagshaw, Sean M., Ostermann, Marlies, Bagshaw, Sean M, Wald, Ron, Adhikari, Neill K.J., Bellomo, Rinaldo, Dreyfuss, Didier, Du, Bin, Gallagher, Martin P., Gaudry, Stéphane, Hoste, Eric A., Lamontagne, François, Joannidis, Michael, Liu, Kathleen D., McAuley, Daniel F., McGuinness, Shay P., Nichol, Alistair D., Ostermann, Marlies, Palevsky, Paul M., Qiu, Haibo, Pettilä, Ville, Schneider, Antoine G., Smith, Orla M., Vaara, Suvi T., Weir, Matthew, Bellomo, Rinaldo, Eastwood, Glenn M., Peck, Leah, Young, Helen, Kruger, Peter, Laurie, Gordon, Saylor, Emma, Meyer, Jason, Venz, Ellen, Wetzig, Krista, French, Craig, McGain, Forbes, Mulder, John, Fennessy, Gerard, Koottayi, Sathyajith, Bates, Samantha, Towns, Miriam, Morgan, Rebecca, Tippett, Anna, Udy, Andrew, Mason, Chris, Licari, Elisa, Gantner, Dashiell, McClure, Jason, Nichol, Alistair, McCracken, Phoebe, Board, Jasmin, Martin, Emma, Vallance, Shirley, Young, Meredith, Vladic, Chelsey, McGloughlin, Steve, Gattas, David, Buhr, Heidi, Coles, Jennifer, Hutch, Debra, Wun, James, Cole, Louise, Whitehead, Christina, Lowrey, Julie, Masters, Kristy, Gresham, Rebecca, Campbell, Victoria, Gutierrez, David, Brailsford, Jane, Forbes, Loretta, Murray, Lauren, Maguire, Teena, NiChonghaile, Martina, Orford, Neil, Bone, Allison, Elderkin, Tania, Salerno, Tania, Chimunda, Tim, Fletcher, Jason, Broadfield, Emma, Porwal, Sanjay, Knott, Cameron, Boschert, Catherine, Smith, Julie, Richardson, Angus, Hill, Dianne, Duke, Graeme, Oziemski, Peter, Cegarra, Santiago, Chan, Peter, Welsh, Deborah, Hunter, Stephanie, Roodenburg, Owen, Dyett, John, Kokotsis, Nicos, Moser, Max, Yang, Yang, Padayachee, Laven, Vetro, Joseph, Gangopadhyay, Himangsu, Kaufman, Melissa, Ghosh, Angaj, Said, Simone, Patel, Alpesh, Bihari, Shailesh, Matheson, Elisha, Jin, Xia, Shrestha, Tapaswi, Schwartz, Kate, Gallagher, Martin P., Cross, Rosalba, Cheung, Winston, Wong, Helen, Kol, Mark, Shah, Asim, Wang, Amanda Y., Endre, Zoltan, Bradford, Celia, Janin, Pierre, Finfer, Simon, Diel, Naomi, Gatward, Jonathan, Hammond, Naomi, Delaney, Anthony, Bass, Frances, Yarad, Elizabeth, Buscher, Hergen, Reynolds, Claire, Baker, Nerilee, Joannidis, Michael, Bellmann, Romuald, Peer, Andreas, Hasslacher, Julia, Koglberger, Paul, Klein, Sebastian, Zotter, Klemens, Brandtner, Anna, Finkenstedt, Armin, Ditlbacher, Adelheid, Hartig, Frank, Fries, Dietmar, Bachler, Mirjam, Schenk, Bettina, Wagner, Martin, Staudinger, Thomas, Tiller, Esther, Schellongowski, Peter, Bojic, Andja, Hoste, Eric A., Bracke, Stephanie, De Crop, Luc, Vermeiren, Daisy, Thome, Fernando, Chiella, Bianca, Fendt, Lucia, Antunes, Veronica, Maisonneuve-Rosemont, Lafrance, Jean-Philippe, Lamontagne, François, D’Aragon, Frédérick, St-Arnaud, Charles, Mayette, Michael, Carbonnaeu, Élaine, Marchand, Joannie, Masse, Marie-Hélène, Ladouceur, Marilène, Turgeon, Alexis F., Lauzier, François, Bellemare, David, Langis Francoeur, Charles, LeBlanc, Guillaume, Guilbault, Gabrielle, Grenier, Stéphanie, Cloutier, Eve, Boivin, Annick, Delisle-Thibault, Charles, Giannakouros, Panagiota, Costerousse, Olivier, Cailhier, Jean-François, Carrier, François-Martin, Ghamraoui, Ali, Lebrasseur, Martine, Benettaib, Fatna, Salamé, Maya, Boumahni, Dounia, Tung Sia, Ying, Naud, Jean-François, Roy, Isabelle, Stelfox, Henry T., Ruddell, Stacey, Manns, Braden J., Duggan, Shelley, Carney, Dominic, Barchard, Jennifer, Whitlock, Richard P., Belley-Cote, Emilie, Savija, Nevena, Sabev, Alexandra, Campbell, Troy, Creary, Thais, Devereaux, Kelson, Brodutch, Shira, Rigatto, Claudio, Paunovic, Bojan, Mooney, Owen, Glybina, Anna, Harasemiw, Oksana, Di Nella, Michelle, Harmon, John, Mehta, Navdeep, Lakatos, Louis, Haslam, Nicole, Lellouche, Francois, Simon, Mathieu, Tung, Ying, Lizotte, Patricia, Bourchard, Pierre-Alexandre, Rochwerg, Bram, Karachi, Tim, Millen, Tina, Muscedere, John, Maslove, David, Gordon Boyd, J., Sibley, Stephanie, Drover, John, Hunt, Miranda, Georgescu, Ilinca, Wax, Randy, Lenga, Ilan, Sridhar, Kavita, Steele, Andrew, Fusco, Kelly, Ghate, Taneera, Tolibas, Michael, Robinson, Holly, Weir, Matthew A., Taneja, Ravi, Ball, Ian M., Garg, Amit, Campbell, Eileen, Ovsenek, Athena, Bagshaw, Sean M., van Diepen, Sean, Baig, Nadia, Magder, Sheldon, Yao, Han, Alam, Ahsan, Campisi, Josie, MacIntyre, Erika, Rokosh, Ella, Scherr, Kimberly, Lapinsky, Stephen, Mehta, Sangeeta, Shah, Sumesh, Niven, Daniel J., Stelfox, Henry T., Ruddell, Stacey, Russell, Michael, Jim, Kym, Brown, Gillian, Oxtoby, Kerry, Hall, Adam, Benoit, Luc, Sokolowski, Colleen, Prasad, Bhanu, Rao, Jag, Giebel, Shelley, Kutsogiannis, Demetrios J., Thompson, Patricia, Thompson, Tayne, Cirone, Robert, Kavikondala, Kanthi, Soth, Mark, Clarke, France, Takaoka, Alyson, Wald, Ron, Mazer, David, Burns, Karen, Friedrich, Jan, Klein, David, Sandhu, Gyan, Santos, Marlene, Khalid, Imrana, Hodder, Jennifer, Dodek, Peter, Ayas, Najib, Alcuaz, Victoria, Suen, Gabriel, Rewa, Oleksa, Singh, Gurmeet, Norris, Sean, Gibson, Neil, Arias, Castro, Shami, Aysha, Pelletier, Celine, Adhikari, Neill K.J., Zahirieh, Alireza, Amaral, Andre, Marinoff, Nicole, Kaur, Navjot, Perez, Adic, Wang, Jane, Haljan, Gregory, Condin, Christopher, McIntyre, Lauralyn, Gomes, Brigette, Porteous, Rebecca, Watpool, Irene, Hiremath, Swapnil, Clark, Edward, Herridge, Margaret S., Backhouse, Felicity, Elizabeth Wilcox, M., Walczak, Karolina, Ki, Vincent, Sharman, Asheer, Romano, Martin, Bagshaw, Sean M., Noel Gibney, R.T., Romanovsky, Adam S., Rewa, Oleksa, McCoshen, Lorena, Baig, Nadia, Wood, Gordon, Ovakim, Daniel, Auld, Fiona, Carney, Gayle, Duan, Meili, Ji, Xiaojun, Guo, Dongchen, Qi, Zhili, Lin, Jin, Zhang, Meng, Dong, Lei, Liu, Jingfeng, Liu, Pei, Zhi, Deyuan, Bai, Guoqiang, Qiu, Yu, Yang, Ziqi, Bai, Jing, Liu, Zhuang, Zhuang, Haizhou, Wang, Haiman, Li, Jian, Zhao, Mengya, Zhou, Xiao, Shi, Xianqing, Ye, Baning, Liu, Manli, Wu, Jing, Fu, Yongjian, Long, Dali, Pan, Yu, Wang, Jinlong, Mei, Huaxian, Zhang, Songsong, Wen, Mingxiang, Yang, Enyu, Mu, Sijie, Li, Jianquan, Hu, Tingting, Qin, Bingyu, Li, Min, Wang, Cunzhen, Dong, Xin, Wang, Kaiwu, Wang, Haibo, Yang, Jianxu, Du, Bin, Wang, Chuanyao, Wang, Dongxin, Li, Nan, Yu, Zhui, Xu, Song, Yao, Lan, Hou, Guo, Liu, Zhou, Lu, Liping, Lian, Yingtao, Wang, Chunting, Zhang, Jichen, Ding, Ruiqi, Qi, Guoqing, Wang, Qizhi, Wang, Peng, Meng, Zhaoli, Chen, Man, Hu, Xiaobo, He, Xiandi, Zhao, Shibing, Hang, Lele, Li, Rui, Qin, Suhui, Lu, Kun, Dun, Shijuan, Liu, Cheng, Zhou, Qi, Chen, Zhenzhen, Mei, Jing, Zhang, Minwei, Xu, Hao, Lin, Jincan, Shi, Qindong, Fu, Lijuan, Zeng, Qinjing, Ma, Hongye, Yan, Jinqi, Gao, Lan, Liu, Hongjuan, Zhang, Lei, Li, Hao, He, Xiaona, Fan, Jingqun, Guo, Litao, Liu, Yu, Wang, Xue, Sun, Jingjing, Liu, Zhongmin, Yang, Juan, Ding, Lili, Sheng, Lulu, Liu, Xingang, Yan, Jie, Wang, Quihui, Wang, Yifeng, Zhao, Dan, Zhao, Shuangping, Hu, Chenghuan, Li, Jing, Deng, Fuxing, Qiu, Haibo, Yang, Yi, Mo, Min, Pan, Chun, Wu, Changde, Huang, Yingzi, Huang, Lili, Liu, Airan, Pettilä, Ville, Vaara, Suvi T., Korhonen, Anna-Maija, Törnblom, Sanna, Sutinen, Sari, Pettilä, Leena, Heinonen, Jonna, Lappi, Eliria, Suhonen, Taria, Karlsson, Sari, Hoppu, Sanna, Jalkanen, Ville, Kuitunen, Anne, Levoranta, Markus, Långsjö, Jaakko, Ristimäki, Sanna, Malila, Kaisa, Wootten, Anna, Varila, Simo, Järvisalo, Mikko J, Inkinen, Outi, Kentala, Satu, Leivo, Keijo, Haltia, Paivi, Dreyfuss, Didier, Ricard, Jean-Damien, Messika, Jonathan, Tiagarajah, Abirami, Emery, Malo, Dechanet, Aline, Gernez, Coralie, Roux, Damien, Martin-Lefevre, Laurent, Fiancette, Maud, Vinatier, Isabelle, Claude Lacherade, Jean, Colin, Gwenhaël, Lebert, Christine, Azais, Marie-Ange, Yehia, Aihem, Pouplet, Caroline, Henry- Lagarrigue, Matthieu, Seguin, Amélie, Crosby, Laura, Maizel, Julien, Titeca-Beauport, Dimitri, Combes, Alain, Nieszkowska, Ania, Masi, Paul, Demoule, Alexandre, Mayaux, Julien, Dres, Martin, Morawiec, Elise, Decalvele, Maxens, Demiri, Suela, Faure, Morgane, Marios, Clémence, Mallet, Maxime, Amélie Ordon, Marie, Morizot, Laura, Cantien, Marie, Pousset, François, Gaudry, Stéphane, Poirson, Florent, Cohen, Yves, Argaud, Laurent, Cour, Martin, Bitker, Laurent, Simon, Marie, Hernu, Romain, Baudry, Thomas, De La Salle, Sylvie, Robine, Adrien, Sedillot, Nicholas, Tchenio, Xavier, Bouisse, Camille, Roux, Sylvie, Barbar, Davide, Trusson, Rémi, Tamion, Fabienne, Grangé, Steven, Carpentier, Dorothée, Chevrel, Guillaume, Ensenyat-Martin, Luis, Marque, Sophie, Quenot, Jean-Pierre, Andreu, Pascal, Dargent, Auguste, Large, Audrey, Chudeau, Nicolas, Landais, Mickael, Derrien, Benoit, Christophe Callahan, Jean, Guitton, Christophe, Le Moal, Charlène, Robert, Alain, Asehnoune, Karim, Cinotti, Raphaël, Grillot, Nicolas, Demeure, Dominique, Vinsonneau, Christophe, Rahmani, Imen, Marzouk, Mehdi, Dekeyser, Thibault, Sejourne, Caroline, Verlay, Mélanie, Thevenin, Fabienne, Delecolle, Lucie, Didier Thevenin, Lens, Souweine, Bertrand, Coupez, Elisabeth, Adda, Mireille, Eraldi, Jean-Pierre, Marchalot, Antoine, De Prost, Nicolas, Mekontso Dessap, Armand, Razazi, Keyvan, Meziani, Ferhat, Boisrame-Helms, Julie, Clere-Jehl, Raphael, Delabranche, Xavier, Kummerlen, Christine, Merdji, Hamid, Monnier, Alexandra, Rabouel, Yannick, Rahmani, Hassene, Allam, Hayat, Chenaf, Samir, Franja, Vincenta, Pons, Bertrand, Carles, Michel, Martino, Frédéric, Richard, Régine, Zuber, Benjamin, Lacave, Guillaume, Lakhal, Karim, Rozec, Bertrand, Dang Van, Hoa, Boulet, Éric, Dubos, René, Fadel, Fouad, Cleophax, Cedric, Dufour, Nicolas, Grant, Caroline, Thuong, Marie, Reignier, Jean, Canet, Emmanuel, Nicolet, Laurent, Boulain, Thierry, Nay, Mai-Anh, Benzekri, Dalila, Barbier, François, Bretagnol, Anne, Kamel, Toufik, Mathonnet, Armelle, Muller, Grégoire, Skarzynski, Marie, Rossi, Julie, Pradet, Amandine, Dos Santos, Sandra, Guery, Aurore, Muller, Lucie, Felix, Luis, Bohé, Julien, Thiéry, Guillaume, Aissaoui, Nadia, Vimpere, Damien, Commeureuc, Morgane, Diehl, Jean-Luc, Guerot, Emmanuel, Liangos, Orfeas, Wittig, Monika, Zarbock, Alexander, Küllmar, Mira, van Waegeningh, Thomas, Rosenow, Nadine, Nichol, Alistair D., Brickell, Kathy, Doran, Peter, Murray, Patrick T., Landoni, Giovanni, Lembo, Rosalba, Zangrillo, Alberto, Monti, Giacomo, Tozzi, Margherita, Marzaroli, Matteo, Lombardi, Gaetano, Paternoster, Gianluca, Vitiello, Michelangelo, McGuinness, Shay, Parke, Rachael, Butler, Magdalena, Gilder, Eileen, Cowdrey, Keri-Anne, Wallace, Samantha, Hallion, Jane, Woolett, Melissa, Neal, Philippa, Duffy, Karina, Long, Stephanie, McArthur, Colin, Simmonds, Catherine, Chen, Yan, McConnochie, Rachael, Newby, Lynette, Knight, David, Henderson, Seton, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Vander Hayden, Kymbalee, Burke, Tara, Bailey, Matthew, Freebairn, Ross, Chadwick, Lesley, Park, Penelope, Rolls, Christine, Thomas, Liz, Buehner, Ulrike, Williams, Erin, Albrett, Jonathan, Kirkham, Simon, Jackson, Carolyn, Browne, Troy, Goodson, Jennifer, Jackson, David, Houghton, James, Callender, Owen, Higson, Vicki, Keet, Owen, Dominy, Clive, Young, Paul, Hunt, Anna, Judd, Harriet, Lawrence, Cassie, Olatunji, Shaanti, Robertson, Yvonne, Latimer-Bell, Charlotte, Hendry, Deborah, Mckay-Vucago, Agnes, Beehre, Nina, Lesona, Eden, Navarra, Leanlove, Robinson, Chelsea, Jang, Ryan, Junge, Andrea, Lambert, Bridget, Schneider, Antoine G., Thibault, Michel, Eckert, Philippe, Kissling, Sébastien, Polychronopoulos, Erietta, Poli, Elettra, Altarelli, Marco, Schnorf, Madeleine, Abed Mallaird, Samia, Heidegger, Claudia, Perret, Aurelie, Montillier, Philippe, Sangla, Frederic, Neils, Seigenthaller, De Watteville, Aude, Phull, Mandeep-Kaur, George, Aparna, Hussain, Nauman, Pogreban, Tatiana, Lobaz, Steve, Daniels, Alison, Cunningham, Mishell, Kerr, Deborah, Nicholson, Alice, Shanmugasundaram, Pradeep, Abrams, Judith, Manso, Katarina, Hambrook, Geraldine, McKerrow, Elizabeth, Salva, Juvy, Foulkes, Stephen, Wise, Matthew, Morgan, Matt, Brooks, Jenny, Cole, Jade, Michelle Davies, Tracy, Hill, Helen, Thomas, Emma, Vizcaychipi, Marcela, Baharlo, Behrad, Carungcong, Jaime, Costa, Patricia, Martins, Laura, Kapoor, Ritoo, Hazelton, Tracy, Moon, Angela, Musselwhite, Janine, Shelley, Ben, McCall, Philip, Ostermann, Marlies, Arbane, Gill, Bociek, Aneta, Marotti, Martina, Lim, Rosario, Campos, Sara, Grau Novellas, Neus, Cennamo, Armando, Slack, Andrew, Wyncoll, Duncan, Camporota, Luigi, Sparkes, Simon, Tilley, Rosalinde, Rattray, Austin, Moreland, Gayle, Duffy, Jane, McGonigal, Elizabeth, Hopkins, Philip, Finney, Clare, Smith, John, Noble, Harriet, Watson, Hayley, Harris, Claire-Louise, Clarey, Emma, Corcoran, Eleanor, Beck, James, Howcroft, Clare, Youngs, Nora, Wilby, Elizabeth, Ogg, Bethan, Wolverson, Adam, Lee, Sandra, Butler, Susie, Okubanjo, Maryanne, Hindle, Julia, Welters, Ingeborg, Williams, Karen, Johnson, Emily, Patrick-Heselton, Julie, Shaw, David, Waugh, Victoria, Stewart, Richard, Mwaura, Esther, Wren, Lynn, Mew, Louise, Sutherland, Sara-Beth, Adderley, Jane, Ruddy, Jim, Harkins, Margaret, Kaye, Callum, Scott, Teresa, Mitchell, Wendy, Anderson, Felicity, Willox, Fiona, Jagannathan, Vijay, Clark, Michele, Purv, Sarah, Sharman, Andrew, Meredith, Megan, Ryan, Lucy, Conner, Louise, Peters, Cecilia, Harvey, Dan, Roshdy, Ashraf, Collins, Amy, Sim, Malcolm, Henderson, Steven, Chee, Nigel, Pitts, Sally, Bowman, Katie, Dilawershah, Maria, Vamplew, Luke, Howe, Elizabeth, Rogers, Paula, Hernandez, Clara, Prendergast, Clara, Benton, Jane, Rosenberg, Alex, Forni, Lui G., Grant, Alice, Carvelli, Paula, Raithatha, Ajay, Bird, Sarah, Richardson, Max, Needham, Matthew, Hirst, Claire, Ball, Jonathan, Leaver, Susannah, Howlett, Luisa, Castro Delgado, Carlos, Farnell-Ward, Sarah, Farrah, Helen, Gray, Geraldine, Joseph, Gipsy, Robinson, Francesca, Tridente, Ascanio, Harrop, Clare, Shuker, Karen, McLaughlan, Derek, Ramsey, Judith, Meehan, Sharon, Oliver Rose, Bernd, Reece-Anthony, Rosie, Gurung, Babita, Whitehouse, Tony, Snelson, Catherine, Veenith, Tonny, Johnston, Andy, Cooper, Lauren, Carrera, Ron, Ellis, Karen, Fellows, Emma, Harkett, Samanth, Bergin, Colin, Spruce, Elaine, Despy, Liesl, Goundry, Stephanie, Dooley, Natalie, Mason, Tracy, Clark, Amy, Dignam, Gemma, Ward, Geraldine, Attwood, Ben, Parsons, Penny, Mason, Sophie, Margarson, Michael, Lord, Jenny, McGlone, Philip, Hodgson, Luke E., Chadbourn, Indra, Gomez, Raquel, Margalef, Jordi, Pretorius, Rinus, Hamshere, Alexandra, Carter, Joseph, Cahill, Hazel, Grainger, Lia, Howard, Kate, Forshaw, Greg, Guy, Zoe, Kashani, Kianoush B., Albright, Robert C., Amsbaugh, Amy, Stoltenberg, Anita, Niven, Alexander S., Lynch, Matthew, O’Mara, AnnMarie, Naeem, Syed, Sharif, Sairah, McKenney Goulart, Joyce, Lynch, Matthew, O’Mara, AnnMarie, Naeem, Syed, Sharif, Sairah, McKenney Goulart, Joyce, Tolwani, Ashita, Lyas, Claretha, Latta, Laura, Bihorac, Azra, Hashemighouchani, Haleh, Efron, Philip, Ruppert, Matthew, Cupka, Julie, Kiley, Sean, Carson, Joshua, White, Peggy, Omalay, George, Brown, Sherry, Velez, Laura, Marceron, Alina, Neyra, Javier A., Carlos Aycinena, Juan, Elias, Madona, Ortiz-Soriano, Victor M., Hauschild, Caroline, and Dorfman, Robert

Published
2024
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178. Effects of Empagliflozin on Fluid Overload, Weight, and Blood Pressure in CKD

Author

Mayne, Kaitlin J., Staplin, Natalie, Keane, David F., Wanner, Christoph, Brenner, Susanne, Cejka, Vladimir, Stegbauer, Johannes, Judge, Parminder K., Preiss, David, Emberson, Jonathan, Trinca, Daniele, Dayanandan, Rejive, Lee, Ryonfa, Nolan, John, Omata, Akiko, Green, Jennifer B., Cherney, David Z.I., Hooi, Lai Seong, Pontremoli, Roberto, Tuttle, Katherine R., Lees, Jennifer S., Mark, Patrick B., Davies, Simon J., Hauske, Sibylle J., Steubl, Dominik, Brückmann, Martina, Landray, Martin J., Baigent, Colin, Haynes, Richard, Herrington, William G., Baigent, Colin, Landray, Martin J., Wanner, Christoph, Herrington, William G., Haynes, Richard, Green, Jennifer B., Hauske, Sibylle J., Brueckmann, Martina, Hopley, Mark, von-Eynatten, Maximillian, George, Jyothis, Brenner, Susanne, Cheung, Alfred K., Preiss, David, Liu, Zhi-Hong, Li, Jing, Hooi, Laiseong, Liu, Wen, Kadowaki, Takashi, Nangaku, Masaomi, Levin, Adeera, Cherney, David, Pontremoli, Roberto, Maggioni, Aldo P., Staplin, Natalie, Emberson, Jonathan, Hantel, Stefan, Goto, Shinya, Deo, Rajat, Tuttle, Katherine R., Hill, Michael, Judge, Parminder, Mayne, Kaitlin J., Ng, Sarah Y.A., Rossello, Xavier, Sammons, Emily, Zhu, Doreen, Sandercock, Peter, Bilous, Rudolf, Herzog, Charles, Whelton, Paul, Wittes, Janet, Bennett, Derrick, Achiri, Patricia, Ambrose, Chrissie, Badin, Cristina, Barton, Jill, Brown, Richard, Burke, Andy, Butler, Sebastian, Dayanandan, Rejive, Donaldson, Pia, Dykas, Robert, Fletcher, Lucy, Frederick, Kate, Kingston, Hannah, Gray, Mo, Harding, Emily, Hashimoto, Akiko, Howie, Lyn, Hurley, Susan, Lee, Ryonfa, Luker, Nik, Murphy, Kevin, Nakahara, Mariko, Nolan, John, Nunn, Michelle, Mulligan, Sorcha, Omata, Akiko, Pickworth, Sandra, Qiao, YanRu, Shah, Shraddha, Taylor, Karen, Timadjer, Alison, Willett, Monique, Wincott, Liz, Yan, Qin, Yu, Hui, Bowman, Louise, Chen, Fang, Clarke, Robert, Goonasekera, Michelle, Haynes, Richard, Herrington, William G., Judge, Parminder, Karsan, Waseem, Mafham, Marion, Mayne, Kaitlin J., Ng, Sarah Y. A., Preiss, David, Reith, Christina, Sammons, Emily, Zayed, Mohammed, Zhu, Doreen, Ellison, Ritva, Moys, Rowan, Stevens, Will, Verdel, Kevin, Wallendszus, Karl, Bowler, Chris, Brewer, Anna, Measor, Andy, Cui, Guanguo, Daniels, Charles, Field, Angela, Goodenough, Bob, Lawson, Ashley, Mostefai, Youcef, Radhakrishnan, Dheeptha, Syed, Samee, Xia, Shuang, Adewuyi-Dalton, Ruth, Arnold, Thomas, Beneat, Anne-Marie, Bhatt, Anoushka, Bird, Chloe, Breach, Andrew, Brown, Laura, Caple, Mark, Chavagnon, Tatyana, Chung, Karen, Clark, Sarah, Condurache, Luminita, Eichstadt, Katarzyna, Obrero, Marta Espino, Forest, Scarlett, French, Helen, Goodwin, Nick, Gordon, Andrew, Gordon, Joanne, Guest, Cat, Harding, Tina, Hill, Michael, Hozak, Michal, Lacey, Matthew, MacLean, David, Messinger, Louise, Moffat, Stewart, Radley, Martin, Shenton, Claire, Tipper, Sarah, Tyler, Jon, Weaving, Lesley, Wheeler, James, Williams, Elissa, Williams, Tim, Woodhouse, Hamish, Chamberlain, Angela, Chambers, Jo, Davies, Joanne, Donaldson, Denise, Faria-Shayler, Pati, Fleming-Brown, Denise, Ingell, Jennifer, Knott, Carol, Liew, Anna, Lochhead, Helen, Meek, Juliette, Rodriguez-Bachiller, Isabel, Wilson, Andrea, Zettergren, Patrick, AitSadi, Rach, Barton, Ian, Baxter, Alex, Bu, Yonghong, Danel, Lukasz, Grotjahn, Sonja, Kurien, Rijo, Lay, Michael, Maskill, Archie, Murawska, Aleksandra, Raff, Rachel, Young, Allen, Baigent, Colin, Haynes, Richard, Herrington, William G., Landray, Martin J., Preiss, David, Emberson, Jonathan, Sardell, Rebecca, Staplin, Natalie, Wanner, Christoph, Brenner, Susanne, Cejka, Vladimir, Fajardo-Moser, Marcela, Hartner, Christian, Poehler, Doris, Renner, Janina, Scheidemantel, Franziska, Haynes, Richard, Preiss, David, Herrington, William G., Judge, Parminder, Zhu, Doreen, Ng, Sarah Y. A., Mayne, Kaitlin J., Badin, Cristina, Chambers, Jo, Davies, Joanne, Donaldson, Denise, Gray, Mo, Harding, Emily, Ingell, Jenny, Qiao, Yanru, Shah, Shraddha, Wilson, Andrea, Zettergren, Patrick, Wanner, Christoph, Brenner, Susanne, Cejka, Vladimir, Ghavampour, Sharang, Knoppe, Anja, Schmidt-Gurtler, Hans, Dumann, Hubert, Merscher, Sybille, Patecki, Margret, Schlieper, Georg Rainer, Torp, Anke, Weber, Bianca, Zietz, Maja, Sitter, Thomas, Fuessl, Louise, Krappe, Julia, Loutan, Jerome, Vielhauer, Volker, Andriaccio, Luciano, Maurer, Magdalena, Winkelmann, Bernhard, Dursch, Martin, Seifert, Linda, Tenbusch, Linda, Weinmann-Menke, Julia, Boedecker, Simone, KaluzaSchilling, Wiebke, Kraus, Daniel, Krieger, Carina, Schmude, Margit, Schreiber, Anne, Eckrich, Ewelina, Tschope, Diethelm, Arbi, Abdulwahab, Lee-Barkey, Young, Stratmann, Bernd, Prib, Natalie, Rolfsmeier, Sina, Schneider, Irina, Rump, Lars, Stegbauer, Johannes, Pötz, Christine, Schemmelmann, Mara, Schmidt, Claudia, Haller, Hermann, Kaufeld, Jessica, Menne, Jan, Bahlmann-Kroll, Elisabeth, Bergner, Angela, Haynes, Richard, Herrington, William G., Zhu, Doreen, Gavrila, Madita, Lafferty, Kathryn, Rabara, Ria, Ruse, Sally, Weetman, Maria, Byrne, Cath, Jesky, Mark, Cowley, Alison, McHaffie, Emma, Waterfall, Holly, Taylor, Jo, Bough, Laura, Phillips, Thomas, Goodwin, Barbara Winter-, Frankel, Andrew, Tomlinson, James, Alegata, Marlon, Almasarwah, Rashid, Apostolidi, Anthoula, Vourvou, Maria, Walters, Thomas, Ugni, Shiva, Gunda, Smita, Oluyombo, Rotimi, Brindle, Vicki, Coutts, Ping, Fuller, Tracy, Nadar, Evelyn, Wong, Christopher, Goldsmith, Christopher, Barnes, Sherald, Bennett, Ann, Burston, Claire, Hope, Samantha, Hunt, Nicola, Kurian, Lini, Fish, Richard, Farrugia, Daniela, Lee, Judy, Sadler, Emma, Turner, Hannah, Clarke, Helen, Carnall, Victoria, Benyon, Sarah, Blake, Caroline, Estcourt, Stephanie, Piper, Jane, Morgan, Neal, Hutchinson, Carolyn, McKinley, Teresa, Doulton, Tim, Delaney, Michael, Montasser, Mahmoud, Hansen, Jenny, Loader, David, Moon, Angela, Morris, Frances, Fraser, Donald, Ali, Mohammad Alhadj, Griffin, Sian, Latif, Farah, Witczak, Justyna, Wonnacott, Alexa, Jeffers, Lynda, Webley, Yvette, Bell, Samira, Cosgrove, Leanne, Craik, Rachel, Murray, Shona, Khwaja, Arif, Jackson, Yvonne, Mbuyisa, Angeline, Sellars, Rachel, Lewington, Andrew, Baker, Richard, Dorey, Suzannah, Tobin, Kay, Wheatley, Rosalyn, Patel, Rajan, Mark, Patrick, Rankin, Alastair, Sullivan, Michael, Forsyth, Kirsty, and McDougall, Rowan

Published
2024
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179. Bank Of Mum And Dad: Have You Protected Your Investment?

Author

Knott, Henny

Subjects
House buying -- Finance -- Contracts -- Management, Company business management, Company financing, Contract agreement, Business, international
Abstract

It is more difficult than ever for young people to get a foot on the housing ladder. With rising property prices, growing inflation and the cost-of-living crisis increasing outgoings, young [...]

Published
2024

180. White Tea extract induces lipolytic activity and inhibits adipogenesis in human subcutaneous (pre)-adipocytes

Author

Wenck Horst, Gallinat Stefan, Schepky Andreas, Grönniger Elke, Siegner Ralf, Holtzmann Ursula, Knott Anja, Söhle Jörn, Stäb Franz, and Winnefeld Marc

Subjects
Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627
Abstract

Abstract Background The dramatic increase in obesity-related diseases emphasizes the need to elucidate the cellular and molecular mechanisms underlying fat metabolism. To investigate how natural substances influence lipolysis and adipogenesis, we determined the effects of White Tea extract on cultured human subcutaneous preadipocytes and adipocytes. Methods For our in vitro studies we used a White Tea extract solution that contained polyphenols and methylxanthines. Utilizing cultured human preadipocytes we investigated White Tea extract solution-induced inhibition of triglyceride incorporation during adipogenesis and possible effects on cell viability. In vitro studies on human adipocytes were performed aiming to elucidate the efficacy of White Tea extract solution to stimulate lipolytic activity. To characterize White Tea extract solution-mediated effects on a molecular level, we analyzed gene expression of essential adipogenesis-related transcription factors by qRT-PCR and determined the expression of the transcription factor ADD1/SREBP-1c on the protein level utilizing immunofluorescence analysis. Results Our data show that incubation of preadipocytes with White Tea extract solution significantly decreased triglyceride incorporation during adipogenesis in a dose-dependent manner (n = 10) without affecting cell viability (n = 10). These effects were, at least in part, mediated by EGCG (n = 10, 50 μM). In addition, White Tea extract solution also stimulated lipolytic activity in adipocytes (n = 7). Differentiating preadipocytes cultivated in the presence of 0.5% White Tea extract solution showed a decrease in PPARγ, ADD1/SREBP-1c, C/EBPα and C/EBPδ mRNA levels. Moreover, the expression of the transcription factor ADD1/SREBP-1c was not only decreased on the mRNA but also on the protein level. Conclusion White Tea extract is a natural source that effectively inhibits adipogenesis and stimulates lipolysis-activity. Therefore, it can be utilized to modulate different levels of the adipocyte life cycle.

Published
2009
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184. Characteristics and time course of benzodiazepine-type new psychoactive substance detections in Australia: results from the Emerging Drugs Network of Australia - Victoria project 2020-2022

Author

Syrjanen, Rebekka, Greene, Shaun L., Weber, Courtney, Smith, Jennifer L., Hodgson, Sarah E., Abouchedid, Rachelle, Gerostamoulos, Dimitri, Maplesden, Jacqueline, Knott, Jonathan, Hollerer, Hans, Rotella, Joe-Anthony, Graudins, Andis, and Schumann, Jennifer L.

Published
2023
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186. Mechanopathology of biofilm-like Mycobacterium tuberculosis cords

Author

Mishra, Richa, Hannebelle, Melanie, Patil, Vishal P., Dubois, Anaëlle, Garcia-Mouton, Cristina, Kirsch, Gabriela M., Jan, Maxime, Sharma, Kunal, Guex, Nicolas, Sordet-Dessimoz, Jessica, Perez-Gil, Jesus, Prakash, Manu, Knott, Graham W., Dhar, Neeraj, McKinney, John D., and Thacker, Vivek V.

Published
2023
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188. A Comparison of Histotripsy and Percutaneous Cryoablation in a Chronic Healthy Swine Kidney Model

Author

Couillard, Allison B., Zlevor, Annie M., Ziemlewicz, Timothy J., Kisting, Meridith A., Knott, Emily, Rossebo, Annika E., White, Jim, Lubner, Meghan G., Gettle, Lori Mankowski, Hinshaw, J. Louis, Mao, Lu, Stoffregen, William, Swietlik, John F., Knavel-Koepsel, Erica, Stratchko, Lindsay, Abel, E. Jason, Xu, Zhen, Lee, Fred T., Jr., and Laeseke, Paul F.

Published
2023
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189. Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation

Author

Pekayvaz, Kami, Gold, Christoph, Hoseinpour, Parandis, Engel, Anouk, Martinez-Navarro, Alejandro, Eivers, Luke, Coletti, Raffaele, Joppich, Markus, Dionísio, Flávio, Kaiser, Rainer, Tomas, Lukas, Janjic, Aleksandar, Knott, Maximilian, Mehari, Fitsumbirhan, Polewka, Vivien, Kirschner, Megan, Boda, Annegret, Nicolai, Leo, Schulz, Heiko, Titova, Anna, Kilani, Badr, Lorenz, Michael, Fingerle-Rowson, Günter, Bucala, Richard, Enard, Wolfgang, Zimmer, Ralf, Weber, Christian, Libby, Peter, Schulz, Christian, Massberg, Steffen, and Stark, Konstantin

Published
2023
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190. Cancer-specific loss of TERT activation sensitizes glioblastoma to DNA damage

Author

Amen, Alexandra M, Fellmann, Christof, Soczek, Katarzyna M, Ren, Shawn M, Lew, Rachel J, Knott, Gavin J, Park, Jesslyn E, McKinney, Andrew M, Mancini, Andrew, Doudna, Jennifer A, and Costello, Joseph F

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Brain Disorders, Genetics, Cancer, Neurosciences, Brain Cancer, Rare Diseases, Generic health relevance, Animals, Antineoplastic Agents, Alkylating, Astrocytes, Brain Neoplasms, Cell Line, Tumor, Cell Proliferation, DNA Damage, Drug Resistance, Neoplasm, Female, GA-Binding Protein Transcription Factor, Gene Expression Regulation, Neoplastic, Gene Knockdown Techniques, Gene Knockout Techniques, Glioblastoma, HEK293 Cells, Humans, Mice, Mutation, Promoter Regions, Genetic, Protein Isoforms, Telomerase, Temozolomide, Xenograft Model Antitumor Assays, TERT, cancer, CRISPR, glioblastoma, temozolomide
Abstract

Most glioblastomas (GBMs) achieve cellular immortality by acquiring a mutation in the telomerase reverse transcriptase (TERT) promoter. TERT promoter mutations create a binding site for a GA binding protein (GABP) transcription factor complex, whose assembly at the promoter is associated with TERT reactivation and telomere maintenance. Here, we demonstrate increased binding of a specific GABPB1L-isoform-containing complex to the mutant TERT promoter. Furthermore, we find that TERT promoter mutant GBM cells, unlike wild-type cells, exhibit a critical near-term dependence on GABPB1L for proliferation, notably also posttumor establishment in vivo. Up-regulation of the protein paralogue GABPB2, which is normally expressed at very low levels, can rescue this dependence. More importantly, when combined with frontline temozolomide (TMZ) chemotherapy, inducible GABPB1L knockdown and the associated TERT reduction led to an impaired DNA damage response that resulted in profoundly reduced growth of intracranial GBM tumors. Together, these findings provide insights into the mechanism of cancer-specific TERT regulation, uncover rapid effects of GABPB1L-mediated TERT suppression in GBM maintenance, and establish GABPB1L inhibition in combination with chemotherapy as a therapeutic strategy for TERT promoter mutant GBM.

Published
2021

191. Controlling and enhancing CRISPR systems

Author

Shivram, Haridha, Cress, Brady F, Knott, Gavin J, and Doudna, Jennifer A

Subjects
Biochemistry and Cell Biology, Biological Sciences, Antibiosis, Archaea, Bacteria, Bacteriophages, CRISPR-Associated Protein 9, CRISPR-Cas Systems, Clustered Regularly Interspaced Short Palindromic Repeats, Gene Editing, Gene Expression Regulation, Archaeal, Gene Expression Regulation, Bacterial, Genetic Engineering, Humans, Interspersed Repetitive Sequences, RNA, Guide, Kinetoplastida, Medicinal and Biomolecular Chemistry, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medicinal and biomolecular chemistry
Abstract

Many bacterial and archaeal organisms use clustered regularly interspaced short palindromic repeats-CRISPR associated (CRISPR-Cas) systems to defend themselves from mobile genetic elements. These CRISPR-Cas systems are classified into six types based on their composition and mechanism. CRISPR-Cas enzymes are widely used for genome editing and offer immense therapeutic opportunity to treat genetic diseases. To realize their full potential, it is important to control the timing, duration, efficiency and specificity of CRISPR-Cas enzyme activities. In this Review we discuss the mechanisms of natural CRISPR-Cas regulatory biomolecules and engineering strategies that enhance or inhibit CRISPR-Cas immunity by altering enzyme function. We also discuss the potential applications of these CRISPR regulators and highlight unanswered questions about their evolution and purpose in nature.

Published
2021

192. Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy

Author

Fozouni, Parinaz, Son, Sungmin, Díaz de León Derby, María, Knott, Gavin J, Gray, Carley N, D'Ambrosio, Michael V, Zhao, Chunyu, Switz, Neil A, Kumar, G Renuka, Stephens, Stephanie I, Boehm, Daniela, Tsou, Chia-Lin, Shu, Jeffrey, Bhuiya, Abdul, Armstrong, Maxim, Harris, Andrew R, Chen, Pei-Yi, Osterloh, Jeannette M, Meyer-Franke, Anke, Joehnk, Bastian, Walcott, Keith, Sil, Anita, Langelier, Charles, Pollard, Katherine S, Crawford, Emily D, Puschnik, Andreas S, Phelps, Maira, Kistler, Amy, DeRisi, Joseph L, Doudna, Jennifer A, Fletcher, Daniel A, and Ott, Melanie

Subjects
Pneumonia & Influenza, Biodefense, Lung, Vaccine Related, Prevention, Infectious Diseases, Bioengineering, Emerging Infectious Diseases, 4.1 Discovery and preclinical testing of markers and technologies, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Infection, Good Health and Well Being, Animals, COVID-19 Nucleic Acid Testing, CRISPR-Cas Systems, Cell Line, Cell Phone, Coronavirus Nucleocapsid Proteins, Humans, Nasopharynx, Optical Imaging, Phosphoproteins, Point-of-Care Testing, RNA Interference, RNA, Viral, Sensitivity and Specificity, Viral Load, COVID-19, CRISPR Dx, CRISPR-Cas13, SARS-CoV-2, mobile phone microscopy, point-of-care diagnostics, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

The December 2019 outbreak of a novel respiratory virus, SARS-CoV-2, has become an ongoing global pandemic due in part to the challenge of identifying symptomatic, asymptomatic, and pre-symptomatic carriers of the virus. CRISPR diagnostics can augment gold-standard PCR-based testing if they can be made rapid, portable, and accurate. Here, we report the development of an amplification-free CRISPR-Cas13a assay for direct detection of SARS-CoV-2 from nasal swab RNA that can be read with a mobile phone microscope. The assay achieved ∼100 copies/μL sensitivity in under 30 min of measurement time and accurately detected pre-extracted RNA from a set of positive clinical samples in under 5 min. We combined crRNAs targeting SARS-CoV-2 RNA to improve sensitivity and specificity and directly quantified viral load using enzyme kinetics. Integrated with a reader device based on a mobile phone, this assay has the potential to enable rapid, low-cost, point-of-care screening for SARS-CoV-2.

Published
2021

193. Continent-wide declines in shallow reef life over a decade of ocean warming

Author

Edgar, Graham J., Stuart-Smith, Rick D., Heather, Freddie J., Barrett, Neville S., Turak, Emre, Sweatman, Hugh, Emslie, Michael J., Brock, Danny J., Hicks, Jamie, French, Ben, Baker, Susan C., Howe, Steffan A., Jordan, Alan, Knott, Nathan A., Mooney, Peter, Cooper, Antonia T., Oh, Elizabeth S., Soler, German A., Mellin, Camille, Ling, Scott D., Dunic, Jillian C., Turnbull, John W., Day, Paul B., Larkin, Meryl F., Seroussi, Yanir, Stuart-Smith, Jemina, Clausius, Ella, Davis, Tom R., Shields, Joe, Shields, Derek, Johnson, Olivia J., Fuchs, Yann Herrera, Denis-Roy, Lara, Jones, Tyson, and Bates, Amanda E.

Published
2023
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194. An Adjusted Treatment Comparison Comparing Amivantamab Versus Real-World Clinical Practice in Europe and the United States for Patients with Advanced Non-Small Cell Lung Cancer with Activating Epidermal Growth Factor Receptor Exon 20 Insertion Mutations

Author

Chouaid, Christos, Bosquet, Lise, Girard, Nicolas, Kron, Anna, Scheffler, Matthias, Griesinger, Frank, Sebastian, Martin, Trigo, Jose, Viteri, Santiago, Knott, Craig, Rodrigues, Bernardo, Rahhali, Nora, Cabrieto, Jedelyn, Diels, Joris, Perualila, Nolen J., Schioppa, Claudio A., Sermon, Jan, Toueg, Raphael, Erdmann, Nicole, Mielke, Janka, Nematian-Samani, Mehregan, Martin-Fernandez, Cristina, Pfaira, Innocent, Li, Tracy, Mahadevia, Parthiv, and Wolf, Jürgen

Published
2023
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199. The Response of Private Academic Library Directors to Dual Pandemics and Opportunities for Collective Advocacy

Author

Dana Adrienne Knott

Abstract

Through a critical phenomenological approach, this study captured the lived experiences of directors in the Ohio Private Academic Libraries (OPAL) consortium and their responses to dual pandemics, the COVID-19 pandemic and the pandemic of racism. Individual qualitative semi-structured interviews were conducted with ten OPAL directors to examine their roles as leaders in times of upheaval. Findings indicate that the pandemics amplified challenges in emotional and practical ways. Directors contended with emotional labor marked by ambiguity and burnout. Practical challenges (staff reductions, enforcing safety protocols, and the Great Resignation) further impacted morale. Racially just, equitable systems encourage workplaces defined by compassion, autonomy, and respect. Thus, directors must prioritize antiracism actions to dismantle white supremacy and racial capitalism in their libraries. [The dissertation citations contained here are published with the permission of ProQuest LLC. Further reproduction is prohibited without permission. Copies of dissertations may be obtained by Telephone (800) 1-800-521-0600. Web page: http://www.proquest.com/en-US/products/dissertations/individuals.shtml.]

Published
2022

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