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This article presents the results of an interdisciplinary study combining archaeology, osteology, and stable isotope analyses. The geological conditions and richness of megalithic graves in Falbygden is suitable for studies of Neolithic human remains. Nevertheless, the Late Neolithic period (2350-1700 BC) is poorly investigated. This paper explores new knowledge of the Late Neolithic megalithic population in Falbygden. In-depth osteological and archaeological studies focusing on a single gallery grave (Falkoping stad 5) were conducted. Radiocarbon dating and carbon, nitrogen, and strontium isotope analyses of teeth from twenty-one individuals revealed the time of the grave’s use, as well as the subsistence and mobility practices of the buried individuals. The grave was already in use during the first part of the Late Neolithic and used into the second part of the period by individuals of different origin. Furthermore, the results indicated changing population dynamics in the Late Neolithic Falbygden, with increased human mobility, variability in subsistence strategies, and growing population density.

A new approach is proposed to derive evapotranspiration (E) and irrigation requirements by implementing the combination equation models of Penman–Monteith and Shuttleworth and Wallace with surface parameters and resistances derived from Sentinel-2 data. Surface parameters are derived from Sentinel-2 and used as an input in these models; namely: the hemispherical shortwave albedo, leaf area index and water status of the soil and canopy ensemble evaluated by using a shortwave infrared-based index. The proposed approach has been validated with data acquired during the GRAPEX (Grape Remote-sensing Atmospheric Profile and Evapotranspiration eXperiment) in California irrigated vineyards. The E products obtained with the combination equation models are evaluated by using eddy covariance flux tower measurements and are additionally compared with surface energy balance models with Landsat-7 and -8 thermal infrared data. The Shuttleworth and Wallace (S-W S-2) model provides an accuracy comparable to thermal-based methods when using local meteorological data, with daily E errors < 1 mm/day, which increased from 1 to 1.5 mm/day using meteorological forcing data from atmospheric models. The advantage of using the S-W S-2 modeling approach for monitoring ET is the high temporal revisit time of the Sentinel-2 satellites and the finer pixel resolution. These results suggest that, by integrating the thermal-based data fusion approach with the S-W S-2 modeling scheme, there is the potential to increase the frequency and reliability of satellite-based daily evapotranspiration products.

Here a new, intrinsically pluripotent, CD45-negative population from human cord blood, termed unrestricted somatic stem cells (USSCs) is described. This rare population grows adherently and can be expanded to 10(15) cells without losing pluripotency. In vitro USSCs showed homogeneous differentiation into osteoblasts, chondroblasts, adipocytes, and hematopoietic and neural cells including astrocytes and neurons that express neurofilament, sodium channel protein, and various neurotransmitter phenotypes. Stereotactic implantation of USSCs into intact adult rat brain revealed that human Tau-positive cells persisted for up to 3 mo and showed migratory activity and a typical neuron-like morphology. In vivo differentiation of USSCs along mesodermal and endodermal pathways was demonstrated in animal models. Bony reconstitution was observed after transplantation of USSC-loaded calcium phosphate cylinders in nude rat femurs. Chondrogenesis occurred after transplanting cell-loaded gelfoam sponges into nude mice. Transplantation of USSCs in a noninjury model, the preimmune fetal sheep, resulted in up to 5% human hematopoietic engraftment. More than 20% albumin-producing human parenchymal hepatic cells with absence of cell fusion and substantial numbers of human cardiomyocytes in both atria and ventricles of the sheep heart were detected many months after USSC transplantation. No tumor formation was observed in any of these animals.

Accurate and frequent monitoring of evapotranspiration (ET) at sub-field scales can provide valuable information for agricultural water management, quantifying crop water use and stress toward the goal of increasing crop water use efficiency and production. Using land-surface temperature (LST) data retrieved from Landsat thermal infrared (TIR) imagery, along with surface reflectance data describing albedo and vegetation cover fraction, surface energy balance models can generate ET maps down to a 30 m spatial resolution. However, the temporal sampling by such maps can be limited by the relatively infrequent revisit period of Landsat data (8 days for combined Landsats 7 and 8), especially in cloudy areas experiencing rapid changes in moisture status. The Sentinel-2 (S2) satellites, as a good complement to the Landsat system, provide surface reflectance data at 10–20 m spatial resolution and 5 day revisit period but do not have a thermal sensor. On the other hand, the Visible Infrared Imaging Radiometer Suite (VIIRS) provides TIR data on a near-daily basis with 375 m resolution, which can be refined through thermal sharpening using S2 reflectances. This study assesses the utility of augmenting the Harmonized Landsat and Sentinel-2 (HLS) dataset with S2-sharpened VIIRS as a thermal proxy source on S2 overpass days, enabling 30 m ET mapping at a potential combined frequency of 2–3 days (including Landsat). The value added by including VIIRS-S2 is assessed both retrospectively and operationally in comparison with flux tower observations collected from several U.S. agricultural sites covering a range of crop types. In particular, we evaluate the performance of VIIRS-S2 ET estimates as a function of VIIRS view angle and cloud masking approach. VIIRS-S2 ET retrievals (MAE of 0.49 mm d−1 against observations) generally show comparable accuracy to Landsat ET (0.45 mm d−1) on days of commensurate overpass, but with decreasing performance at large VIIRS view angles. Low-quality VIIRS-S2 ET retrievals linked to imperfect VIIRS/S2 cloud masking are also discussed, and caution is required when applying such data for generating ET timeseries. Fused daily ET time series benefited during the peak growing season from the improved multi-source temporal sampling afforded by VIIRS-S2, particularly in cloudy regions and over surfaces with rapidly changing vegetation conditions, and value added for real-time monitoring applications is discussed. This work demonstrates the utility and feasibility of augmenting the HLS dataset with sharpened VIIRS TIR imagery on S2 overpass dates for generating high spatiotemporal resolution ET products.

In 2016, an extraordinary burial of a young adult individual was discovered at the Late Pre-Pottery Neolithic B (LPPNB, 7,500-6,900 BCE) settlement of Ba'ja in southern Jordan. This burial has exceptional grave goods and an elaborate grave construction. It suggests discussing anew reconstructions of early Neolithic social structures. In this article, we will summarize former theories on the emergence of leadership and hierarchies and present a multivariate model according to which anthropological and archaeological data of the burial will be analyzed. In conclusion, we surmise that early Neolithic hierarchization in southern Jordan was based on corporate pathways to power rather than self-interested aggrandizers. However, some aspects of the burial point to regional exchange networks of prestige goods, a trait considered characteristic of network based leadership. In line with anthropological and sociological research, we argue that pathways to power should be considered as relational processes that can be understood only when comparing traits of the outstanding person to her/his social environment.

A well-planned irrigation management strategy is crucial for successful wine grape production and is highly dependent on accurate assessments of water stress. Precision irrigation practices may benefit from the quantification of within-field spatial variability and temporal patterns of evapotranspiration (ET). A spatiotemporal modeling framework is proposed to delineate the vineyard into homogeneous areas (i.e., management zones) according to their ET patterns. The dataset for this study relied on ET retrievals from multiple satellite platforms, generating estimates at high spatial (30 m) and temporal (daily) resolutions for a Vitis vinifera Pinot noir vineyard in the Central Valley of California during the growing seasons of 2015-2018. Time-series decomposition was used to deconstruct the time series of each pixel into three components: long-term trend, seasonality, and remainder, which indicates daily fluctuations. For each time-series component, a time-series clustering (TSC) algorithm was applied to partition the time series of all pixels into homogeneous groups and generate TSC maps. The TSC maps were compared for spatial similarities using the V-measure statistic. A random forest (RF) classification algorithm was used for each TSC map against six environmental variables (elevation, slope, northness, lithology, topographic wetness index, and soil type) to check for spatial association between ET-TSC maps and the local characteristics in the vineyard. Finally, the TSC maps were used as independent variables against yield (ton ha-1) using analysis of variance (ANOVA) to assess whether the TSC maps explained yield variability. The trend and seasonality TSC maps had a moderate spatial association (V = 0.49), while the remainder showed dissimilar spatial patterns to seasonality and trend. The RF model showed high error matrix-based prediction accuracy levels ranging between 86% and 90%. For the trend and seasonality models, the most important predictor was soil type, followed by elevation, while the remainder TSC was strongly linked with northness spatial variability. The yield levels corresponding to the two clusters in all TSC were significantly different. These findings enabled spatial quantification of ET time series at different temporal scales that may benefit within-season decision-making regarding the amounts, timing, intervals, and location of irrigation. The proposed framework may be applicable to other cases in both agricultural systems and environmental modeling.

Sensory axon T-like branching (bifurcation) in neurons from dorsal root ganglia and cranial sensory ganglia depends on the molecular signaling cascade involving the secreted factor C-type natriuretic peptide, the natriuretic peptide receptor guanylyl cyclase B (GC-B; also known as Npr2) and cGMP-dependent protein kinase I (cGKI, also known as PKGI). The bifurcation of cranial nerves is suggested to be important for information processing by second-order neurons in the hindbrain or spinal cord. Indeed, mice with a spontaneous GC-B loss of function mutation (Npr2cn/cn) display an impaired bifurcation of auditory nerve (AN) fibers. However, these mice did not show any obvious sign of impaired basal hearing. Here, we demonstrate that mice with a targeted inactivation of the GC-B gene (Npr2lacZ/lacZ, GC-B KO mice) show an elevation of audiometric thresholds. In the inner ear, the cochlear hair cells in GC-B KO mice were nevertheless similar to those from wild type mice, justified by the typical expression of functionally relevant marker proteins. However, efferent cholinergic feedback to inner and outer hair cells was reduced in GC-B KO mice, linked to very likely reduced rapid efferent feedback. Sound-evoked AN responses of GC-B KO mice were elevated, a feature that is known to occur when the efferent axo-dendritic feedback on AN is compromised. Furthermore, late sound-evoked brainstem responses were significantly delayed in GC-B KO mice. This delay in sound response was accompanied by a weaker sensitivity of the auditory steady state response to amplitude-modulated sound stimuli. Finally, the acoustic startle response (ASR) – one of the fastest auditory responses – and the prepulse inhibition of the ASR indicated significant changes in temporal precision of auditory processing. These findings suggest that GC-B-controlled axon bifurcation of spiral ganglion neurons is important for proper activation of second-order neurons in the hindbrain and is a prerequisite for proper temporal auditory processing likely by establishing accurate efferent top-down control circuits. These data hypothesize that the bifurcation pattern of cranial nerves is important to shape spatial and temporal information processing for sensory feedback control.

Both TH2-dependent helminth killing and suppression of the TH2 effector response have been attributed to macrophages (MΦ) activated by IL-4 (M(IL-4)). To investigate how M(IL-4) contribute to diverse infection outcomes, the MΦ compartment of susceptible BALB/c mice and more resistant C57BL/6 mice was profiled during infection of the pleural cavity with the filarial nematode, Litomosoides sigmodontis. C57BL/6 mice exhibited a profoundly expanded resident MΦ (resMΦ) population, which was gradually replenished from the bone marrow in an age-dependent manner. Infection status did not alter the bone-marrow derived contribution to the resMΦ population, confirming local proliferation as the driver of resMΦ expansion. Significantly less resMΦ expansion was observed in the susceptible BALB/c strain, which instead exhibited an influx of monocytes that assumed an immunosuppressive PD-L2+ phenotype. Inhibition of monocyte recruitment enhanced nematode killing. Thus, the balance of monocytic vs. resident M(IL-4) numbers varies between inbred mouse strains and impacts infection outcome.

Background: Accumulating evidence suggests that tinnitus may occur despite normal auditory sensitivity, probably linked to partial degeneration of the cochlear nerve and damage of the inner hair cell (IHC) synapse. Damage to the IHC synapses and deafferentation may occur even after moderate noise exposure. For both salicylate- and noise-induced tinnitus, aberrant N-methyl-d-aspartate (NMDA) receptor activation and related auditory nerve excitation have been suggested as origin of cochlear tinnitus. Accordingly, NMDA receptor inhibition has been proposed as a pharmacologic approach for treatment of synaptopathic tinnitus. Methods: Round-window application of the NMDA receptor antagonist AM-101 (Esketamine hydrochloride gel; Auris Medical AG, Basel, Switzerland) was tested in an animal model of tinnitus induced by acute traumatic noise. The study included the quantification of IHC ribbon synapses as a correlate for deafferentation as well as the measurement of the auditory brainstem response (ABR) to close-threshold sensation level stimuli as an indication of sound-induced auditory nerve activity. Results: We have shown that AM-101 reduced the trauma-induced loss of IHC ribbons and counteracted the decline of ABR wave I amplitude generated in the cochlea/auditory nerve. Conclusion: Local round-window application of AM-101 may be a promising therapeutic intervention for the treatment of synaptopathic tinnitus.

In viticulture, deficit irrigation strategies are often implemented to control vine canopy growth and to impose stress at critical stages of vine growth to improve wine grape quality. To support deficit irrigation scheduling, remote sensing technologies can be employed in the mapping of evapotranspiration (ET) at the field to sub-field scales, quantifying time-varying vineyard water requirements and actual water use. In the current study, we investigate the utility of ET maps derived from thermal infrared satellite imagery over a vineyard in the Central Valley of California equipped with a variable rate drip irrigation (VRDI) system which enables differential water applications at the 30 × 30 m scale. To support irrigation management at that scale, we utilized a thermal-based multi-sensor data fusion approach to generate weekly total actual ET (ETa) estimates at 30 m spatial resolution, coinciding with the resolution of the Landsat reflectance bands. Crop water requirements (ETc) were defined with a vegetative index (VI)-based approach. To test capacity to capture stress signals, the vineyard was sub-divided into four blocks with different irrigation management strategies and goals, inducing varying degrees of stress during the growing season. Results indicate derived weekly total ET from the thermal-based data fusion approach match well with observations. The thermal-based method was also able to capture the spatial heterogeneity in ET over the vineyard due to a water stress event imposed on two of the four vineyard blocks. This transient stress event was not reflected in the VI-based ETc estimate, highlighting the value of thermal band imaging. While the data fusion system provided valuable information, latency in current satellite data availability, particularly from Landsat, impacts operational applications over the course of a growing season.

The energy delivered to the land surface via insolation is a primary driver of evapotranspiration (ET)—the exchange of water vapor between the land and atmosphere. Spatially distributed ET products are in great demand in the water resource management community for real-time operations and sustainable water use planning. The accuracy and deliverability of these products are determined in part by the characteristics and quality of the insolation data sources used as input to the ET models. This paper investigates the practical utility of three different insolation datasets within the context of a satellite-based remote sensing framework for mapping ET at high spatiotemporal resolution, in an application over the Sacramento⁻San Joaquin Delta region in California. The datasets tested included one reanalysis product: The Climate System Forecast Reanalysis (CFSR) at 0.25° spatial resolution, and two remote sensing insolation products generated with geostationary satellite imagery: a product for the continental United States at 0.2°, developed by the University of Wisconsin Space Sciences and Engineering Center (SSEC) and a coarser resolution (1°) global Clouds and the Earth’s Radiant Energy System (CERES) product. The three insolation data sources were compared to pyranometer data collected at flux towers within the Delta region to establish relative accuracy. The satellite products significantly outperformed CFSR, with root-mean square errors (RMSE) of 2.7, 1.5, and 1.4 MJ·m−2·d−1 for CFSR, CERES, and SSEC, respectively, at daily timesteps. The satellite-based products provided more accurate estimates of cloud occurrence and radiation transmission, while the reanalysis tended to underestimate solar radiation under cloudy-sky conditions. However, this difference in insolation performance did not translate into comparable improvement in the ET retrieval accuracy, where the RMSE in daily ET was 0.98 and 0.94 mm d−1 using the CFSR and SSEC insolation data sources, respectively, for all the flux sites combined. The lack of a notable impact on the aggregate ET performance may be due in part to the predominantly clear-sky conditions prevalent in central California, under which the reanalysis and satellite-based insolation data sources have comparable accuracy. While satellite-based insolation data could improve ET retrieval in more humid regions with greater cloud-cover frequency, over the California Delta and climatologically similar regions in the western U.S., the CFSR data may suffice for real-time ET modeling efforts.

Latinos in the United States have been disproportionately affected by the intersecting epidemics of HIV and sexually transmitted diseases (STDs). We examined correlates of condom use among adult heterosexual Latino men who are members of a large multicounty soccer league in rural North Carolina. Of 222 participants, the mean (plus or minus SD) age was 29.8 plus or minus 8.3 years. Approximately 60% reported Mexico as their country of origin, 60% reported Grade 8 or below as their highest level of education, and 50% reported using condoms during their most recent vaginal intercourse episodes. Adjusting for relationship status, multivariable logistic regression identified four correlates of condom use: having sought health care information from family members (adjusted odds ratio [AOR]=3.68; 95% confidence interval [CI]=1.48-9.13); greater knowledge of HIV transmission and prevention (AOR = 2.61; CI = 1.23-5.54); greater condom use self-efficacy (AOR = 4.45; 95% CI = 2.12-9.36); and greater adherence to traditional masculine norms (AOR = 2.10; 95% CI = 1.02-4.33). Our findings underscore the need for innovative and targeted HIV and STD prevention programming among the emerging Latino community in the southeastern United States.

Mastery of content area reading in science and social studies is demonstrated through writing as well as reading. Integrating writing with reading enhances comprehension because the two are reciprocal processes. Therefore, teachers who implement a variety of writing strategies help students better understand content area texts. This article offers a repertoire of writing strategies that content area teachers in grades 4 to 8 can put into practice before, during, and after reading to strengthen students' comprehension and extend their critical thinking. Strategies described include learning logs, quick writes, listen-stop-write, microthemes, framed paragraphs, text boxes, biopoems, word maps, and ABC books. In using them, students "write to learn," thinking about and interacting with text in a variety of ways. Writing to learn engages students, extends thinking, deepens understanding, and continues the meaning-making process. Teacher feedback and evaluation are important in writing to learn. Several examples of rubrics and checklists as techniques for giving feedback are provided. (Contains 5 tables and 3 figures.)

The ability to accurately monitor and anticipate changes in consumptive water use associated with changing land use and land management is critical to developing sustainable water management strategies in water-limited climatic regions. In this paper, we present an application of a remote sensing data fusion technique for developing high spatiotemporal resolution maps of evapotranspiration (ET) at scales that can be associated with changes in land use. The fusion approach combines ET map timeseries developed using an multi-scale energy balance algorithm applied to thermal data from Earth observation platforms with high spatial but low temporal resolution (e.g., Landsat) and with moderate resolution but frequent temporal coverage (e.g., MODIS (Moderate Resolution Imaging Spectroradiometer)). The approach is applied over the Sacramento-San Joaquin Delta region in California—an area critical to both agricultural production and drinking water supply within the state that has recently experienced stresses on water resources due to a multi-year (2012–2017) extreme drought. ET “datacubes” with 30-m resolution and daily timesteps were constructed for the 2015–2016 water years and related to detailed maps of land use developed at the same spatial scale. The ET retrievals are evaluated at flux sites over multiple land covers to establish a metric of accuracy in the annual water use estimates, yielding root-mean-square errors of 1.0, 0.8, and 0.3 mm day−1 at daily, monthly, and yearly timesteps, respectively, for all sites combined. Annual ET averaged over the Delta changed only 3 mm year−1 between water years, from 822 to 819 mm year−1, translating to an area-integrated total change in consumptive water use of seven thousand acre-feet (TAF). Changes were largest in areas with recorded land-use change between water years—most significantly, fallowing of crop land presumably in response to reductions in water availability and allocations due to the drought. Moreover, the time evolution in water use associated with wetland restoration—an effort aimed at reducing subsidence and carbon emissions within the inner Delta—is assessed using a sample wetland chronosequence. Region-specific matrices of consumptive water use associated with land use changes may be an effective tool for policymakers and farmers to understand how land use conversion could impact consumptive use and demand.

Diversos estudios a nivel mundial señalan la inequidad en salud según categorías étnicas o asociado con el estado de inmigrante. La perspectiva intercultural se aplica, por lo tanto, en países y situaciones muy distintas, y los criterios para definir los grupos sociales enfocados tal como los planteamientos varían según el contexto local. Sin embargo, hay desafíos comunes que son relevantes en todas las situaciones donde el tema de salud y etnicidad se pone de manifiesto. Además, a diferencia de la noción "interculturalidad", los problemas claves que comprometen, por ejemplo, la atención sanitaria para poblaciones indígenas o inmigrantes no son recientes, sino la historia es rica en experiencias previas muy significativas para la actualidad. Desde una visión global e histórica, el presente artículo pone a consideración tres puntos claves: la necesidad de definir adecuadamente a los grupos enfocados para evitar estereotipos culturales y la creación de desigualdades nuevas, el reto de convertir etnicidad en una categoría "saludable" y la reflexión explícita de la dimensión ética y moral, basada en la ética médica codificada y los derechos humanos.Health inequalities are broadly documented for ethnic minority groups and immigrants worldwide. Intercultural perspectives in health are thus developed in very different places and situations. Both the criteria for defining the target groups as well as the ways the health problems of these groups are looked at, are shaped by the particular local context. However, some challenges are common to almost all situations where the topic of ethnic diversity and health is considered. And in contrast to the rather novel term, the issues at stake in "intercultural heath" are not new at all. Against this background, the present article brings into focus three essential points: the necessity of defining ethnicity adequately to avoid stereotyping and the creation of new inequalities; the challenge of converting ethnicity into a helpful and thus "healthy" category in the field of medicine and health; and the need for the integration of explicit and serious reflections on medical ethics and human rights that provide for the normative framework and moral orientation of health activities with indigenous, migrant and other particularly vulnerable groups

Nasal bone fractures are the most common type of facial bone fractures. While the nasal anatomy and closed reduction techniques of nasal fractures are well described, there is a paucity of data reporting on the need for revision rhinoplasty. The objective of this study is to analyze the factors affecting the outcome and need for revision rhinoplasty in patients who underwent closed reduction for nasal bone fracture. From 2010 to 2020, a total of 417 consecutive patients underwent closed nasal reduction. Medical files of the patients were reviewed retrospectively. The rate of rhinoplasty after fracture consolidation was determined. Factors influencing the need for revision rhinoplasty were assessed using univariable and multivariable logistic regression analyses. Forty-seven patients (11.3%) required revision rhinoplasty after fracture healing. Patients who had suffered an additional septum fracture were more likely to undergo rhinoplasty. The risk of the need for open revision rhinoplasty after fracture healing was increased for patients complaining of airway obstruction at the time of cast removal after closed reduction. A certain number of patients will require secondary revision rhinoplasty after closed reduction of a nasal fracture. Subjective airway obstruction at the time of cast removal after closed reduction is a predictor for revision rhinoplasty. Prospective studies are required to support the findings of this investigation. [ABSTRACT FROM AUTHOR]

Evapotranspiration (ET) is a key component of the water balance, especially in arid and semiarid regions. The current study takes advantage of spatially-distributed, near real-time information provided by satellite remote sensing to develop a regional scale ET product derived from remotely-sensed observations. ET is calculated by scaling PET estimated from Moderate Resolution Imaging Spectroradiometer (MODIS) products with downscaled soil moisture derived using the Soil Moisture Ocean Salinity (SMOS) satellite and a second order polynomial regression formula. The MODis-Soil Moisture ET (MOD-SMET) estimates are validated using four flux tower sites in southern Arizona USA, a calibrated empirical ET model, and model output from Version 2 of the North American Land Data Assimilation System (NLDAS-2). Validation against daily eddy covariance ET indicates correlations between 0.63 and 0.83 and root mean square errors (RMSE) between 40 and 96 W/m2. MOD-SMET estimates compare well to the calibrated empirical ET model, with a −0.14 difference in correlation between sites, on average. By comparison, NLDAS-2 models underestimate daily ET compared to both flux towers and MOD-SMET estimates. Our analysis shows the MOD-SMET approach to be effective for estimating ET. Because it requires limited ancillary ground-based data and no site-specific calibration, the method is applicable to regions where ground-based measurements are not available.