2,718 results on '"Klaassen P"'
Search Results
152. Personalized surveillance and aftercare for non-metastasized breast cancer: the NABOR study protocol of a multiple interrupted time series design
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Klaassen-Dekker, A., Drossaert, C. H. C., Van Maaren, M. C., Van Leeuwen-Stok, A. E., Retel, V. P., Korevaar, J. C., and Siesling, S.
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- 2023
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153. PROMISE: effect of protein supplementation on fat-free mass preservation after bariatric surgery, a randomized double-blind placebo-controlled trial
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Taselaar, A. E., Boes, A. J., de Bruin, R. W. F., Kuijper, T. M., Van Lancker, K., van der Harst, E., and Klaassen, R. A.
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- 2023
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154. Psychometric validation of the Pyruvate Kinase Deficiency Diary and Pyruvate Kinase Deficiency Impact Assessment in adults in the phase 3 ACTIVATE trial
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Andrae, David A., Grace, Rachael F., Jewett, Adrian, Foster, Brandon, Klaassen, Robert J., Salek, Sam, Li, Junlong, Tai, Feng, Boscoe, Audra N., and Zagadailov, Erin
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- 2023
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155. How to improve the accuracy of height data from bird tracking devices? An assessment of high-frequency GPS tracking and barometric altimetry in field conditions
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Schaub, Tonio, Millon, Alexandre, De Zutter, Caroline, Buij, Ralph, Chadœuf, Joël, Lee, Simon, Mionnet, Aymeric, and Klaassen, Raymond Hendrikus Gerardus
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- 2023
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156. Does residential exposure to air pollutants influence mortality and cardiovascular morbidity of older people from primary care?
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D’Acquisto, Maurizio Pietro, Krause, Dietmar, Klaassen-Mielke, Renate, Trampisch, Matthias, Trampisch, Hans Joachim, Trampisch, Ulrike, and Rudolf, Henrik
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- 2023
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157. Endogenous small intestinal microbiome determinants of transient colonisation efficiency by bacteria from fermented dairy products: a randomised controlled trial
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Zaccaria, Edoardo, Klaassen, Tim, Alleleyn, Annick M. E., Boekhorst, Jos, Smokvina, Tamara, Kleerebezem, Michiel, and Troost, Freddy J.
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- 2023
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158. Randomized controlled trial evaluating a virtual parenting intervention for young children at risk of obesity: study protocol for Parenting Addressing Early Years Intervention with Coaching Visits in Toronto (PARENT) trial
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Rae, Sarah, Maguire, Jonathon, Aglipay, Mary, Barwick, Melanie, Danavan, Karoon, Haines, Jess, Jenkins, Jennifer, Klaassen, Marie, Moretti, Myla E., Ong, Frank, Persaud, Nav, Porepa, Michelle, Straus, Sharon, Tavares, Erika, Willan, Andrew, and Birken, Catherine
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- 2023
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159. Phase 3 randomised trial of eltrombopag versus standard first-line pharmacological management for newly diagnosed immune thrombocytopaenia (ITP) in children: study protocol
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Shimano, Kristin A, Grace, Rachael F, Despotovic, Jenny M, Neufeld, Ellis J, Klaassen, Robert J, Bennett, Carolyn M, Ma, Clement, London, Wendy B, and Neunert, Cindy
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Biomedical and Clinical Sciences ,Clinical Sciences ,Pediatric ,Hematology ,Clinical Trials and Supportive Activities ,Clinical Research ,Patient Safety ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Benzoates ,Child ,Clinical Trials ,Phase III as Topic ,Humans ,Hydrazines ,Platelet Count ,Purpura ,Thrombocytopenic ,Idiopathic ,Pyrazoles ,Quality of Life ,Randomized Controlled Trials as Topic ,Treatment Outcome ,clinical trials ,haematology ,paediatrics ,Public Health and Health Services ,Other Medical and Health Sciences ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
IntroductionImmune thrombocytopaenia (ITP) is an acquired disorder of low platelets and risk of bleeding. Although many children can be observed until spontaneous remission, others require treatment due to bleeding or impact on health-related quality of life. Standard first-line therapies for those who need intervention include corticosteroids, intravenous immunoglobulin and anti-D globulin, though response to these agents may be only transient. Eltrombopag is an oral thrombopoietin receptor agonist approved for children with chronic ITP who have had an insufficient response to corticosteroids, intravenous immunoglobulin or splenectomy. This protocol paper describes an ongoing open-label, randomised trial comparing eltrombopag to standard first-line management in children with newly diagnosed ITP.Methods and analysisRandomised treatment assignment is 2:1 for eltrombopag versus standard first-line management and is stratified by age and by prior treatment. The primary endpoint of the study is platelet response, defined as ≥3 of 4 weeks with platelets >50×109/L during weeks 6-12 of therapy. Secondary outcomes include number of rescue therapies needed during the first 12 weeks, proportion of patients who do not need ongoing treatment at 12 weeks and 6 months, proportion of patients with a treatment response at 1 year, and number of second-line therapies used in weeks 13-52, as well as changes in regulatory T cells, iron studies, bleeding, health-related quality of life and fatigue. A planned sample size of up to 162 randomised paediatric patients will be enrolled over 2 years at 20 sites.Ethics and disseminationThe study has been approved by the centralised Baylor University Institutional Review Board. The results are expected to be published in 2023.Trial registration numberNCT03939637.
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- 2021
160. Diabetes and Prostate Cancer Outcomes in Obese and Nonobese Men After Radical Prostatectomy.
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Kelkar, Sonia, Oyekunle, Taofik, Eisenberg, Adva, Howard, Lauren, Aronson, William J, Kane, Christopher J, Amling, Christopher L, Cooperberg, Matthew R, Klaassen, Zachary, Terris, Martha K, Freedland, Stephen J, and Csizmadi, Ilona
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BackgroundThe link between diabetes and prostate cancer progression is poorly understood and complicated by obesity. We investigated associations between diabetes and prostate cancer-specific mortality (PCSM), castrate-resistant prostate cancer (CRPC), and metastases in obese and nonobese men undergoing radical prostatectomy (RP).MethodsWe included 4688 men from the Shared Equal Access Regional Cancer Hospital cohort of men undergoing RP from 1988 to 2017. Diabetes prior to RP, anthropometric, and clinical data were abstracted from 6 Veterans Affairs Medical Centers electronic medical records. Primary and secondary outcomes were PCSM and metastases and CRPC, respectively. Multivariable-adjusted hazard ratios (adj-HRs) and 95% confidence intervals (CIs) were estimated for diabetes and PCSM, CRPC, and metastases. Adjusted hazard ratios were also estimated in analyses stratified by obesity (body mass index: nonobese
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- 2021
161. Robotic Versus Open Cystectomy for Bladder Cancer: Synthesizing the Data from Current Systematic Reviews and Meta-Analyses
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Aminoltejari, Khatereh, Hird, Amanda E., Klaassen, Zachary, Satkunasivam, Raj, Kulkarni, Girish S., Luckenbaugh, Amy N., Laviana, Aaron A., Wallis, Christopher J. D., and Clark, Roderick
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- 2023
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162. Is time to castration resistant prostate cancer a potential intermediate end-point for time to metastasis among men initiating androgen deprivation therapy for non-metastatic prostate cancer with rapid PSA doubling time (<9 months)?
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Klaassen, Zachary, Howard, Lauren, Wallis, Christopher J. D., Janes, Jessica L., De Hoedt, Amanda, Aronson, William J., Polascik, Thomas J., Amling, Christopher J., Kane, Christopher J., Cooperberg, Matthew R., Terris, Martha K., Wu, Yuan, and Freedland, Stephen J.
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- 2023
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163. CMB-HD: Astro2020 RFI Response
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Sehgal, Neelima, Aiola, Simone, Akrami, Yashar, Basu, Kaustuv moni, Boylan-Kolchin, Michael, Bryan, Sean, Casey, Caitlin M, Clesse, Sébastien, Cyr-Racine, Francis-Yan, Di Mascolo, Luca, Dicker, Simon, Essinger-Hileman, Thomas, Ferraro, Simone, Fuller, George, Galitzki, Nicholas, Han, Dongwon, Hasselfield, Matthew, Holder, Gil, Jain, Bhuvnesh, Johnson, Bradley R., Johnson, Matthew, Klaassen, Pamela, MacInnis, Amanda, Madhavacheril, Mathew, Mauskopf, Philip, Meerburg, Daan, Meyers, Joel, Mroczkowski, Tony, Mukherjee, Suvodip, Münchmeyer, Moritz, Naess, Sigurd Kirkevold, Nagai, Daisuke, Namikawa, Toshiya, Newburgh, Laura, Nguyen, Nam, Niemack, Michael, Oppenheimer, Benjamin D., Pierpaoli, Elena, Schaan, Emmanuel, Sherwin, Blake, Slosar, Anže, Spergel, David, Switzer, Eric, Trivedi, Pranjal, Tsai, Yu-Dai, van Engelen, Alexander, Wandelt, Benjamin, and Wollack, Edward
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,High Energy Physics - Phenomenology - Abstract
CMB-HD is a proposed ultra-deep (0.5 uk-arcmin), high-resolution (15 arcseconds) millimeter-wave survey over half the sky that would answer many outstanding questions in both fundamental physics of the Universe and astrophysics. This survey would be delivered in 7.5 years of observing 20,000 square degrees, using two new 30-meter-class off-axis cross-Dragone telescopes to be located at Cerro Toco in the Atacama Desert. Each telescope would field 800,000 detectors (200,000 pixels), for a total of 1.6 million detectors., Comment: Response to request for information (RFI) by the Panel of Radio, Millimeter, and Submillimeter Observations from the Ground (RMS) of the Astro2020 Decadal Survey regarding the CMB-HD APC (arXiv:1906.10134). Note some text overlap with original APC. Note also detector count and cost have been reduced by 1/3, and observing time increased by 1/3 compared to original APC; science goals expanded
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- 2020
164. Quality Assessment and Validation of High-Throughput Sequencing for Grapevine Virus Diagnostics
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Soltani, Nourolah, Stevens, Kristian A, Klaassen, Vicki, Hwang, Min-Sook, Golino, Deborah A, and Rwahnih, Maher Al
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Microbiology ,Biological Sciences ,Biotechnology ,Infection ,High-Throughput Nucleotide Sequencing ,Molecular Diagnostic Techniques ,Plant Diseases ,Plant Viruses ,RNA ,Viral ,Reproducibility of Results ,Sensitivity and Specificity ,Vitis ,high-throughput sequencing ,grapevine virus ,validation ,performance assessment ,sensitivity ,specificity ,reproducibility ,repeatability - Abstract
Development of High-Throughput Sequencing (HTS), also known as next generation sequencing, revolutionized diagnostic research of plant viruses. HTS outperforms bioassays and molecular diagnostic assays that are used to screen domestic and quarantine grapevine materials in data throughput, cost, scalability, and detection of novel and highly variant virus species. However, before HTS-based assays can be routinely used for plant virus diagnostics, performance specifications need to be developed and assessed. In this study, we selected 18 virus-infected grapevines as a test panel for measuring performance characteristics of an HTS-based diagnostic assay. Total nucleic acid (TNA) was extracted from petioles and dormant canes of individual samples and constructed libraries were run on Illumina NextSeq 500 instrument using a 75-bp single-end read platform. Sensitivity was 98% measured over 264 distinct virus and viroid infections with a false discovery rate (FDR) of approximately 1 in 5 positives. The results also showed that combining a spring petiole test with a fall cane test increased sensitivity to 100% for this TNA HTS assay. To evaluate extraction methodology, these results were compared to parallel dsRNA extractions. In addition, in a more detailed dilution study, the TNA HTS assay described here consistently performed well down to a dilution of 5%. In that range, sensitivity was 98% with a corresponding FDR of approximately 1 in 5. Repeatability and reproducibility were assessed at 99% and 93%, respectively. The protocol, criteria, and performance levels described here may help to standardize HTS for quality assurance and accreditation purposes in plant quarantine or certification programs.
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- 2021
165. Sequencing a Strawberry Germplasm Collection Reveals New Viral Genetic Diversity and the Basis for New RT-qPCR Assays
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Diaz-Lara, Alfredo, Stevens, Kristian A, Klaassen, Vicki, Hwang, Min Sook, and Rwahnih, Maher Al
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Plant Biology ,Biological Sciences ,Biotechnology ,Infection ,Chromosome Mapping ,Fragaria ,Genetic Variation ,Genome ,Viral ,High-Throughput Nucleotide Sequencing ,Metagenomics ,Phylogeny ,Plant Diseases ,RNA Viruses ,Reproducibility of Results ,Reverse Transcriptase Polymerase Chain Reaction ,strawberry ,germplasm ,virome ,high throughput sequencing ,virus ,detection ,RT-qPCR ,diagnostic assay ,Microbiology - Abstract
Viruses are considered of major importance in strawberry (Fragaria × ananassa Duchesne) production given their negative impact on plant vigor and growth. Strawberry accessions from the National Clonal Germplasm Repository were screened for viruses using high throughput sequencing (HTS). Analyses of sequence information from 45 plants identified multiple variants of 14 known viruses, comprising strawberry mottle virus (SMoV), beet pseudo yellows virus (BPYV), strawberry pallidosis-associated virus (SPaV), tomato ringspot virus (ToRSV), strawberry mild yellow edge virus (SMYEV), strawberry vein banding virus (SVBV), strawberry crinkle virus (SCV), strawberry polerovirus 1 (SPV-1), apple mosaic virus (ApMV), strawberry chlorotic fleck virus (SCFaV), strawberry crinivirus 4 (SCrV-4), strawberry crinivirus 3 (SCrV-3), Fragaria chiloensis latent virus (FClLV) and Fragaria chiloensis cryptic virus (FCCV). Genetic diversity of sequenced virus isolates was investigated via sequence homology analysis, and partial-genome sequences were deposited into GenBank. To confirm the HTS results and expand the detection of strawberry viruses, new reverse transcription quantitative PCR (RT-qPCR) assays were designed for the above-listed viruses. Further in silico and in vitro validation of the new diagnostic assays indicated high efficiency and reliability. Thus, the occurrence of different viruses, including divergent variants, among the strawberries was verified. This is the first viral metagenomic survey in strawberry, additionally, this study describes the design and validation of multiple RT-qPCR assays for strawberry viruses, which represent important detection tools for clean plant programs.
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- 2021
166. ALMA and NACO observations towards the young exoring transit system J1407 (V1400 Cen)
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Kenworthy, M. A., Klaassen, P. D., Min, M., van der Marel, N., Bohn, A. J., Kama, M., Triaud, A., Hales, A., Monkiewicz, J., Scott, E., and Mamajek, E. E.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Our aim was to directly detect the thermal emission of the putative exoring system responsible for the complex deep transits observed in the light curve for the young Sco-Cen star 1SWASP J140747.93-394542.6 (V1400 Cen, hereafter J1407), confirming it as the occulter seen in May 2007, and to determine its orbital parameters with respect to the star. We used the Atacama Large Millimeter/submillimeter Array (ALMA) to observe the field centred on J1407 in the 340 GHz (Band 7) continuum in order to determine the flux and astrometric location of the ring system relative to the star. We used the VLT/NACO camera to observe the J1407 system in March 2019 and to search for the central planetary mass object at thermal infrared wavelengths. We detect no point source at the expected location of J1407, and derive an upper limit $3\sigma$ level of $57.6~\mu\rm{Jy}$. There is a point source detected at an angular separation consistent with the expected location for a free-floating ring system that occulted J1407 in May 2007, with a flux of $89~\mu\rm{Jy}$ consistent with optically thin dust surrounding a massive substellar companion. At 3.8 microns with the NACO camera, we detect the star J1407 but no other additional point sources within 1.3 arcseconds of the star, with a lower bound on the sensitivity of $6M_{Jup}$ at the location of the ALMA source, and down to $4M_{Jup}$ in the sky background limit. The ALMA upper limit at the location of J1407 implies that a hypothesised bound ring system is composed of dust smaller than $1\rm{~mm}$ in size, implying a young ring structure. The detected ALMA source has multiple interpretations, including: (i) it is an unbound substellar object surrounded by warm dust in Sco-Cen with an upper mass limit of $6M_{Jup}$, or (ii) it is a background galaxy., Comment: Accepted for publication in A&A (6 pages, 5 figures). Reduced data and reduction scripts on GitHub at https://github.com/mkenworthy/j1407_alma_detection
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- 2019
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167. Spiral arms in the proto-planetary disc HD100453 detected with ALMA: evidence for binary-disc interaction and a vertical temperature gradient
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Rosotti, G. P., Benisty, M., Juhász, A., Teague, R., Clarke, C., Dominik, C., Dullemond, C. P., Klaassen, P. D., Matrà, L., and Stolker, T.
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Scattered light high-resolution imaging of the proto-planetary disc orbiting HD100453 shows two symmetric spiral arms, possibly launched by an external stellar companion. In this paper we present new, sensitive high-resolution ($\sim$30 mas) Band 7 ALMA observations of this source. This is the first source where we find counterparts in the sub-mm continuum to both scattered light spirals. The CO J=3-2 emission line also shows two spiral arms; in this case they can be traced over a more extended radial range, indicating that the southern spiral arm connects to the companion position. This is clear evidence that the companion is responsible for launching the spirals. The pitch angle of the sub-millimeter continuum spirals ($\sim 6 ^{\circ}$) is lower than the one in scattered light ($\sim 16 ^{\circ}$). We show that hydrodynamical simulations of binary-disc interaction can account for the difference in pitch angle only if one takes into account that the midplane is colder than the upper layers of the disc, as expected for the case of externally irradiated discs., Comment: 14 pages, 10 figures; accepted on MNRAS
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- 2019
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168. Carina's Pillars of Destruction: the view from ALMA
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Klaassen, P. D., Reiter, M. R., McLeod, A. F., Mottram, J. C., Dale, J. E., and Gritschneder, M.
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Astrophysics - Astrophysics of Galaxies - Abstract
Forming high-mass stars have a significant effect on their natal environment. Their feedback pathways, including winds, outflows, and ionising radiation, shape the evolution of their surroundings which impacts the formation of the next generation of stars. They create or reveal dense pillars of gas and dust towards the edges of the cavities they clear. They are modelled in feedback simulations, and the sizes and shapes of the pillars produced are consistent with those observed. However, these models predict measurably different kinematics which provides testable discriminants. Here we present the first ALMA Compact Array (ACA) survey of 13 pillars in Carina, observed in $^{12}$CO, $^{13}$CO and C$^{18}$O J=2-1, and the 230 GHz continuum. The pillars in this survey were chosen to cover a wide range in properties relating to the amount and direction of incident radiation, proximity to nearby irradiating clusters and cloud rims, and whether they are detached from the cloud. With these data, we are able to discriminate between models. We generally find pillar velocity dispersions of $<$ 1 km s$^{-1}$ and that the outer few layers of molecular emission in these pillars show no significant offsets from each other, suggesting little bulk internal motions within the pillars. There are instances where the pillars are offset in velocity from their parental cloud rim, and some with no offset, hinting at a stochastic development of these motions., Comment: 24 Pages, 19 figures. Accepted to MNRAS
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- 2019
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169. Chemical complexity in high-mass star formation: An observational and modeling case study of the AFGL 2591 VLA 3 hot core
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Gieser, C., Semenov, D., Beuther, H., Ahmadi, A., Mottram, J. C., Henning, Th., Beltran, M., Maud, L. T., Bosco, F., Leurini, S., Peters, T., Klaassen, P., Kuiper, R., Feng, S., Urquhart, J. S., Moscadelli, L., Csengeri, T., Lumsden, S., Winters, J. M., Suri, S., Zhang, Q., Pudritz, R., Palau, A., Menten, K. M., Galvan-Madrid, R., Wyrowski, F., Schilke, P., Sánchez-Monge, Á., Linz, H., Johnston, K. G., Jiménez-Serra, I., Longmore, S., and Möller, T.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present a detailed observational and modeling study of the hot core VLA 3 in the high-mass star-forming region AFGL 2591, which is a target region of the NOrthern Extended Millimeter Array (NOEMA) large program CORE. Using NOEMA observations at 1.37 mm with an angular resolution of ~0."42 (1 400 au at 3.33 kpc), we derived the physical and chemical structure of the source. We modeled the observed molecular abundances with the chemical evolution code MUSCLE (MUlti Stage ChemicaL codE). Results. With the kinetic temperature tracers CH3CN and H2CO we observe a temperature distribution with a power-law index of q = 0.41+-0.08. Using the visibilities of the continuum emission we derive a density structure with a power-law index of p = 1.7+-0.1. The hot core spectra reveal high molecular abundances and a rich diversity in complex molecules. The majority of the molecules have an asymmetric spatial distribution around the forming protostar(s), which indicates a complex physical structure on scales < 1 400 au. Using MUSCLE, we are able to explain the observed molecular abundance of 10 out of 14 modeled species at an estimated hot core chemical age of ~21 100 years. In contrast to the observational analysis, our chemical modeling predicts a lower density power-law index of p < 1.4. Reasons for this discrepancy are discussed. Conclusions. Combining high spatial resolution observations with detailed chemical modeling allows us to derive a concise picture of the physical and chemical structure of the famous AFGL 2591 hot core. The next steps are to conduct a similar analysis for the whole CORE sample, and then use this analysis to constrain the chemical diversity in high-mass star formation to a much greater depth., Comment: 22 pages, 13 figures, accepted for publication in A&A
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- 2019
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170. Illuminating the Tadpole's metamorphosis I: MUSE observations of a small globule in a sea of ionizing photons
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Reiter, Megan, McLeod, Anna F., Klaassen, Pamela D., Guzmán, Andrés E., Dale, J. E., Mottram, Joseph C., and Garay, Guido
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Astrophysics - Astrophysics of Galaxies - Abstract
We present new MUSE/VLT observations of a small globule in the Carina H II region that hosts the HH 900 jet+outflow system. Data were obtained with the GALACSI ground-layer adaptive optics system in wide-field mode, providing spatially-resolved maps of diagnostic emission lines. These allow us to measure the variation of the physical properties in the globule and jet+outflow system. We find high temperatures ($T_e \approx 10^4$ K), modest extinction ($A_V \approx 2.5$ mag), and modest electron densities ($n_e \approx 200$ cm$^{-3}$) in the ionized gas. Higher excitation lines trace the ionized outflow; both the excitation and ionization in the outflow increase with distance from the opaque globule. In contrast, lower excitation lines that are collisionally de-excited at densities $\gtrsim 10^4$ cm$^{-3}$ trace the highly collimated protostellar jet. Assuming the globule is an isothermal sphere confined by the pressure of the ionization front, we compute a Bonnor-Ebert mass of $\sim 3.7$ M$_{\odot}$. This is two orders of magnitude higher than previous mass estimates, calling into question whether small globules like the Tadpole contribute to the bottom of the IMF. Derived globule properties are consistent with a cloud that has been and/or will be compressed by the ionization front on its surface. At the estimated globule photoevaporation rate of $\sim 5 \times 10^{-7}$ M$_{\odot}$ yr$^{-1}$, the globule will be completely ablated in $\sim 7$ Myr. Stars that form in globules like the Tadpole will emerge into the H II later and may help resolve some of the temporal tension between disk survival and enrichment., Comment: MNRAS, accepted
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- 2019
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171. The Atacama Large Aperture Submillimeter Telescope (AtLAST)
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Klaassen, Pamela, Mroczkowski, Tony, Bryan, Sean, Groppi, Christopher, Basu, Kaustuv, Cicone, Claudia, Dannerbauer, Helmut, De Breuck, Carlos, Fischer, William J., Geach, James, Hatziminaoglou, Evanthia, Holland, Wayne, Kawabe, Ryohei, Sehgal, Neelima, Stanke, Thomas, and van Kampen, Eelco
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The sub-mm sky is a unique window for probing the architecture of the Universe and structures within it. From the discovery of dusty sub-mm galaxies, to the ringed nature of protostellar disks, our understanding of the formation, destruction, and evolution of objects in the Universe requires a comprehensive view of the sub-mm sky. The current generation single-dish sub-mm facilities have shown of the potential for discovery, while interferometers have presented a high resolution view into the finer details. However, our understanding of large-scale structure and our full use of these interferometers is now hampered by the limited sensitivity of our sub-mm view of the universe at larger scales. Thus, now is the time to start planning the next generation of sub-mm single dish facilities, to build on these revolutions in our understanding of the sub-mm sky. Here we present the case for the Atacama Large Aperture Submillimeter Telescope (AtLAST), a concept for a 50m class single dish telescope. We envision AtLAST as a facility operating as an international partnership with a suite of instruments to deliver the transformative science described in many Astro2020 science white papers. A 50m telescope with a high throughput and 1$^\circ$ FoV with a full complement of advanced instrumentation, including highly multiplexed high-resolution spectrometers, continuum cameras and Integral Field Units, AtLAST will have mapping speeds thousands of times greater than any current or planned facility. It will reach confusion limits below $L_*$ in the distant universe and resolve low-mass protostellar cores at the distance of the Galactic Center, providing synergies with upcoming facilities across the spectrum. Located on the Atacama plateau, to observe frequencies un-obtainable by other observatories, AtLAST will enable a fundamentally new understanding of the sub-mm universe at unprecedented depths., Comment: Submitted to call for Astro2020 APC papers
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- 2019
172. Fragmentation, rotation and outflows in the high-mass star-forming region IRAS 23033+5951. A case study of the IRAM NOEMA large program CORE
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Bosco, F., Beuther, H., Ahmadi, A., Mottram, J. C., Kuiper, R., Linz, H., Maud, L., Winters, J. M., Henning, T., Feng, S., Peters, T., Semenov, D., Klaassen, P. D., Schilke, P., Urquhart, J. S., Beltrán, M. T., Lumsden, S. L., Leurini, S., Moscadelli, L., Cesaroni, R., Sánchez-Monge, Á., Palau, A., Pudritz, R., Wyrowski, F., Longmore, S., and team, the CORE
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
The formation process of high-mass stars (>8M$_\odot$) is poorly constrained, particularly, the effects of clump fragmentation creating multiple systems and the mechanism of mass accretion onto the cores. We study the fragmentation of dense gas clumps, and trace the circumstellar rotation and outflows by analyzing observations of the high-mass (~500M$_\odot$) star-forming region IRAS 23033+5951. Using the Northern Extended Millimeter Array (NOEMA) in three configurations and the IRAM 30-m single-dish telescope at 220GHz, we probe the gas and dust emission at an angular resolution of ~0.45arcsec, corresponding to 1900au. In the mm continuum emission, we identify a protostellar cluster with at least four mm-sources, where three of them show a significantly higher peak intensity well above a signal-to-noise ratio of 100. Hierarchical fragmentation from large to small spatial scales is discussed. Two fragments are embedded in rotating structures and drive molecular outflows, traced by $^{13}$CO (2-1) emission. The velocity profiles across two of the cores are similar to Keplerian but are missing the highest velocity components close to the center of rotation, which is a common phenomena from observations like these, and other rotation scenarios are not excluded entirely. Position-velocity diagrams suggest protostellar masses of ~6 and 19M$_\sun$. Rotational temperatures from fitting CH$_3$CN ($12_K-11_K$) spectra are used for estimating the gas temperature and by that the disk stability against gravitational fragmentation, utilizing Toomre's $Q$ parameter. [We] identify only one candidate disk to be unstable against gravitational instability caused by axisymmetric perturbations. The dominant sources cover different evolutionary stages within the same maternal gas clump. The appearance of rotation and outflows of the cores are similar to those found in low-mass star-forming regions., Comment: 23 pages, 16 figures, 5 tables, accepted for publication in A&A
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- 2019
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173. First Generation Heterodyne Instrumentation Concepts for the Atacama Large Aperture Submillimeter Telescope
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Groppi, Christopher, Baryshev, Andrey, Graf, Urs, Wiedner, Martina, Klaassen, Pamela, and Mroczkowski, Tony
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
(abridged) The Atacama Large Aperture Submillimeter Telescope (AtLAST) project aims to build a 50-m-class submm telescope with $>1^\circ$ field of view, high in the Atacama Desert, providing fast and detailed mapping of the mm/submm sky. It will thus serve as a strong complement to existing facilities such as ALMA. ALMA's small field of view ($<15^{\prime\prime}$ at 350 GHz) limits its mapping speed for large surveys. Instead, a single dish with a large field of view such as the AtLAST concept can host large multi-element instruments that can more efficiently map large portions of the sky. Small aperture survey instruments (typically much smaller than $<3\times$ the size of an interferometric array element) can mitigate this somewhat but lack the resolution for accurate recovery of source location and have small collecting areas. Furthermore, small aperture survey instruments do not provide sufficient overlap in the spatial scales they sample to provide a complete reconstruction of extended sources (i.e.\ the zero-spacing information is incomplete in $u,v$-space.) The heterodyne instrumentation for the AtLAST telescope that we consider here will take advantage of extensive developments in the past decade improving the performance and pixel count of heterodyne focal plane arrays. Such instrumentation, with higher pixel counts, has alredy begun to take advantage of integration in the focal planes to increase packaging efficiency over simply stacking modular mixer blocks in the focal plane. We extrapolate from the current state-of-the-art to present concept first-generation heterodyne designs for AtLAST., Comment: to be published in the proceedings of the 30th International Symposium on Space Terahertz Technology (https://www.isstt2019.com/). Final version will appear when the link to the 30th annual proceedings becomes active: https://www.nrao.edu/meetings/isstt/tocs.shtml
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- 2019
174. CMB-HD: An Ultra-Deep, High-Resolution Millimeter-Wave Survey Over Half the Sky
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Sehgal, Neelima, Aiola, Simone, Akrami, Yashar, Basu, Kaustuv, Boylan-Kolchin, Michael, Bryan, Sean, Clesse, Sebastien, Cyr-Racine, Francis-Yan, Di Mascolo, Luca, Dicker, Simon, Essinger-Hileman, Thomas, Ferraro, Simone, Fuller, George M., Han, Dongwon, Hasselfield, Mathew, Holder, Gil, Jain, Bhuvnesh, Johnson, Bradley, Johnson, Matthew, Klaassen, Pamela, Madhavacheril, Mathew, Mauskopf, Philip, Meerburg, Daan, Meyers, Joel, Mroczkowski, Tony, Munchmeyer, Moritz, Naess, Sigurd, Nagai, Daisuke, Namikawa, Toshiya, Newburgh, Laura, Nguyen, Ho Nam, Niemack, Michael, Oppenheimer, Benjamin D., Pierpaoli, Elena, Schaan, Emmanuel, Slosar, Anze, Spergel, David, Switzer, Eric, van Engelen, Alexander, and Wollack, Edward
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,High Energy Physics - Phenomenology - Abstract
A millimeter-wave survey over half the sky, that spans frequencies in the range of 30 to 350 GHz, and that is both an order of magnitude deeper and of higher-resolution than currently funded surveys would yield an enormous gain in understanding of both fundamental physics and astrophysics. By providing such a deep, high-resolution millimeter-wave survey (about 0.5 uK-arcmin noise and 15 arcsecond resolution at 150 GHz), CMB-HD will enable major advances. It will allow 1) the use of gravitational lensing of the primordial microwave background to map the distribution of matter on small scales (k~10/hMpc), which probes dark matter particle properties. It will also allow 2) measurements of the thermal and kinetic Sunyaev-Zel'dovich effects on small scales to map the gas density and gas pressure profiles of halos over a wide field, which probes galaxy evolution and cluster astrophysics. In addition, CMB-HD would allow us to cross critical thresholds in fundamental physics: 3) ruling out or detecting any new, light (< 0.1eV), thermal particles, which could potentially be the dark matter, and 4) testing a wide class of multi-field models that could explain an epoch of inflation in the early Universe. Such a survey would also 5) monitor the transient sky by mapping the full observing region every few days, which opens a new window on gamma-ray bursts, novae, fast radio bursts, and variable active galactic nuclei. Moreover, CMB-HD would 6) provide a census of planets, dwarf planets, and asteroids in the outer Solar System, and 7) enable the detection of exo-Oort clouds around other solar systems, shedding light on planet formation. CMB-HD will deliver this survey in 5 years of observing half the sky, using two new 30-meter-class off-axis cross-Dragone telescopes to be located at Cerro Toco in the Atacama Desert. The telescopes will field about 2.4 million detectors (600,000 pixels) in total., Comment: APC White Paper for the Astro2020 Decadal, with updated proposing team
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- 2019
175. Substructures in the Keplerian disc around the O-type (proto)star G17.64+0.16
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Maud, L. T., Cesaroni, R., Kumar, M. S. N., Rivilla, V. M., Ginsburg, A., Klaassen, P. D., Harsono, D., Sanchez-Monge, A., Ahmadi, A., Allen, V., Beltran, M. T., Beuther, H., Galvan-Madrid, R., Goddi, C., Hoare, M. G., Hogerheijde, M. R., Johnston, K. G., Kuiper, R., Moscadelli, L., Peters, T., Testi, L., van der Tak, F. F. S., and de Wit, W. J.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present the highest angular resolution (20x15mas - 44x33au) Atacama Large Millimeter/sub-millimeter Array (ALMA) observations currently possible of the proto-O-star G17.64+0.16 in Band 6. The Cycle 5 observations with baselines out to 16km probes scales <50au and reveal the rotating disc around G17.64+0.16, a massive forming O-type star. The disc has a ring-like enhancement in the dust emission, especially visible as arc structures to the north and south. The Keplerian kinematics are most prominently seen in the vibrationally excited water line, H2O (Eu=3461.9K). The mass of the central source found by modelling the Keplerian rotation is consistent with 45+/-10Mo. The H30alpha (231.9GHz) radio-recombination line and the SiO (5-4) molecular line were detected at up to the 10 sigma$ level. The estimated disc mass is 0.6-2.6Mo under the optically thin assumption. Analysis of the Toomre Q parameter, in the optically thin regime, indicates that the disc stability is highly dependent on temperature. The disc currently appears stable for temperatures >150K, this does not preclude that the substructures formed earlier through disc fragmentation., Comment: 9 Total, inc references, appendix, long author list, 4 figures (inc appendix)
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- 2019
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176. IRAS23385+6053: An embedded massive cluster in the making
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Cesaroni, R., Beuther, H., Ahmadi, A., Beltran, M. T., Csengeri, T., Galvan-Madrid, R., Gieser, C., Henning, T., Johnston, K. G., Klaassen, P. D., Kuiper, R., Leurini, S., Linz, H., Longmore, S., Lumsden, S. L., Maud, L. T., Moscadelli, L., Mottram, J. C., Palau, A., Peters, T., Pudritz, R. E., Sanchez-Monge, A., Schilke, P., Semenov, D., Suri, S., Urquhart, J. S., Winters, J. M., Zhang, Q., and Zinnecker, H.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
This study is part of the project ``CORE'', an IRAM/NOEMA large program consisting of observations of the millimeter continuum and molecular line emission towards 20 selected high-mass star forming regions. We focus on IRAS23385+6053, which is believed to be the least evolved source of the CORE sample. The observations were performed at ~1.4 mm and employed three configurations of NOEMA and additional single-dish maps, merged with the interferometric data to recover the extended emission. Our correlator setup covered a number of lines from well-known hot core tracers and a few outflow tracers. The angular (~0.45"$-$0.9") and spectral (0.5 km/s) resolutions were sufficient to resolve the clump in IRAS23385+6053 and investigate the existence of large-scale motions due to rotation, infall, or expansion. We find that the clump splits into six distinct cores when observed at sub-arcsecond resolution. These are identified through their 1.4 mm continuum and molecular line emission. We produce maps of the velocity, line width, and rotational temperature from the methanol and methyl cyanide lines, which allow us to investigate the cores and reveal a velocity and temperature gradient in the most massive core. We also find evidence of a bipolar outflow, possibly powered by a low-mass star. We present the tentative detection of a circumstellar self-gravitating disk lying in the most massive core and powering a large-scale outflow previously known in the literature. In our scenario, the star powering the flow is responsible for most of the luminosity of IRAS23385+6053 (~$3000~L_\odot$). The other cores, albeit with masses below the corresponding virial masses, appear to be accreting material from their molecular surroundings and are possibly collapsing or on the verge of collapse. We conclude that we are observing a sample of star-forming cores that is bound to turn into a cluster of massive stars.
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- 2019
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177. Time-Domain Photometry of Protostars at Far-Infrared and Submillimeter Wavelengths
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Fischer, William J., Dunham, Michael, Green, Joel, Hatchell, Jenny, Johnstone, Doug, Battersby, Cara, Klaassen, Pamela, Li, Zhi-Yun, Offner, Stella, Pontoppidan, Klaus, Sewiło, Marta, Stephens, Ian, Tobin, John, Brogan, Crystal, Gutermuth, Robert, Looney, Leslie, Megeath, S. Thomas, Padgett, Deborah, and Roellig, Thomas
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
The majority of the ultimate main-sequence mass of a star is assembled in the protostellar phase, where a forming star is embedded in an infalling envelope and encircled by a protoplanetary disk. Studying mass accretion in protostars is thus a key to understanding how stars gain their mass and ultimately how their disks and planets form and evolve. At this early stage, the dense envelope reprocesses most of the luminosity generated by accretion to far-infrared and submillimeter wavelengths. Time-domain photometry at these wavelengths is needed to probe the physics of accretion onto protostars, but variability studies have so far been limited, in large part because of the difficulty in accessing these wavelengths from the ground. We discuss the scientific progress that would be enabled with far-infrared and submillimeter programs to probe protostellar variability in the nearest kiloparsec., Comment: Science white paper submitted to the Astro2020 Decadal Survey
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- 2019
178. Mapping Galaxy Clusters in the Distant Universe
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Dannerbauer, H., van Kampen, E., Afonso, J., Andreani, P., Battaia, F. Arrigoni, Bertoldi, F., Casey, C., Chen, C. -C., Clements, D. L., De Breuck, C., Frye, B., Geach, J., Harrington, K., Hayashi, M., Jin, S., Klaassen, P., Kohno, K., Lehnert, M. D., Matute, I., Mroczkowski, T., Noble, A., Pappalardo, C., Tamura, Y., and Zavala, J.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present the science case for mapping several thousand galaxy (proto)clusters at z=1-10 with a large aperture single dish sub-mm facility, producing a high-redshift counterpart to local large surveys of rich clusters like the well-studied Abell catalogue. Principal goals of a large survey of distant clusters are the evolution of galaxy clusters over cosmic time and the impact of environment on the evolution and formation of galaxies. To make a big leap forward in this emerging research field, the community would benefit from a large-format, wide-band, direct-detection spectrometer (e.g., based on MKID technology), covering a wide field of ~1 square degree and a frequency coverage from 70 to 700 GHz., Comment: Science white paper submitted to the Astro2020 Decadal Survey
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- 2019
179. 'SZ spectroscopy' in the coming decade: Galaxy cluster cosmology and astrophysics in the submillimeter
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Basu, Kaustuv, Erler, Jens, Chluba, Jens, Delabrouille, Jacques, Hill, J. Colin, Mroczkowski, Tony, Niemack, Michael D., Remazeilles, Mathieu, Sayers, Jack, Scott, Douglas, Vavagiakis, Eve M., Zemcov, Michael, Aravena, Manuel, Bartlett, James G., Battaglia, Nicholas, Bertoldi, Frank, Charmetant, Maude, Golwala, Sunil, Herter, Terry L., Klaassen, Pamela, Komatsu, Eiichiro, Magnelli, Benjamin, Mantz, Adam B., Meerburg, P. Daniel, Melin, Jean-Baptiste, Nagai, Daisuke, Parshley, Stephen C., Pointecouteau, Etienne, Ramos-Ceja, Miriam E., Ruszkowski, Mateusz, Sehgal, Neelima, Stacey, Gordon G., and Sunyaev, Rashid
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Sunyaev-Zeldovich (SZ) effects were first proposed in the 1970s as tools to identify the X-ray emitting hot gas inside massive clusters of galaxies and obtain their velocities relative to the cosmic microwave background (CMB). Yet it is only within the last decade that they have begun to significantly impact astronomical research. Thanks to the rapid developments in CMB instrumentation, measurement of the dominant thermal signature of the SZ effects has become a routine tool to find and characterize large samples of galaxy clusters and to seek deeper understanding of several important astrophysical processes via high-resolution imaging studies of many targets. With the notable exception of the Planck satellite and a few combinations of ground-based observatories, much of this "SZ revolution" has happened in the photometric mode, where observations are made at one or two frequencies in the millimeter regime to maximize the cluster detection significance and minimize the foregrounds. Still, there is much more to learn from detailed and systematic analyses of the SZ spectra across multiple wavelengths, specifically in the submillimeter (>300 GHz) domain. The goal of this Science White Paper is to highlight this particular aspect of SZ research, point out what new and potentially groundbreaking insights can be obtained from these studies, and emphasize why the coming decade can be a golden era for SZ spectral measurements., Comment: Science white paper submitted for the Astro2020 decadal review, 5 pages + references
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- 2019
180. The case for a 'sub-millimeter SDSS': a 3D map of galaxy evolution to z~10
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Geach, James E., Banerji, Manda, Bertoldi, Frank, Bethermin, Matthieu, Casey, Caitlin M., Chen, Chian-Chou, Clements, David L., Cicone, Claudia, Combes, Francoise, Conselice, Christopher, Cooray, Asantha, Coppin, Kristen, Daddi, Emanuele, Dannerbauer, Helmut, Dave, Romeel, Doherty, Matthew, Dunlop, James S., Edge, Alastair, Farrah, Duncan, Franco, Maximilien, Fuller, Gary, Garratt, Tracy, Gear, Walter, Greve, Thomas R., Hatziminaoglou, Evanthia, Hayward, Christopher C., Ivison, Rob J., Kawabe, Ryohei, Klaassen, Pamela, Knudsen, Kirsten K., Kohno, Kotaro, Koprowski, Maciej, Lagos, Claudia D. P., Magdis, Georgios E., Magnelli, Benjamin, McGee, Sean L., Michalowski, Michal, Mroczkowski, Tony, Noroozian, Omid, Oliver, Seb, Riechers, Dominik, Rujopakarn, Wiphu, Scott, Douglas, Serjeant, Stephen, Smith, Matthew W. L., Swinbank, Mark, Tamura, Yoichi, van der Werf, Paul, van Kampen, Eelco, Verma, Aprajita, Vieira, Joaquin, Wagg, Jeff, Walter, Fabian, Wang, Lingyu, Wootten, Al, and Yun, Min S.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Sloan Digital Sky Survey (SDSS) was revolutionary because of the extraordinary breadth and ambition of its optical imaging and spectroscopy. We argue that a 'sub-millimeter SDSS' - a sensitive large-area imaging+spectroscopic survey in the sub-mm window - will revolutionize our understanding of galaxy evolution in the early Universe. By detecting the thermal dust continuum emission and atomic and molecular line emission of galaxies out to z~10 it will be possible to measure the redshifts, star formation rates, dust and gas content of hundreds of thousands of high-z galaxies down to ~L*. Many of these galaxies will have counterparts visible in the deep optical imaging of the Large Synoptic Survey Telescope. This 3D map of galaxy evolution will span the peak epoch of galaxy formation all the way back to cosmic dawn, measuring the co-evolution of the star formation rate density and molecular gas content of galaxies, tracking the production of metals and charting the growth of large-scale structure., Comment: Science White paper submitted to the Astro2020 Decadal Survey
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- 2019
181. The warm and dense Galaxy - tracing the formation of dense cloud structures out to the Galactic Center
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Stanke, Thomas, Beuther, Henrik, Kauffmann, Jens, Klaassen, Pamela, Perez-Beaupuits, Juan-Pablo, Johnstone, Doug, Colombo, Dario, Hacar, Alvaro, Schuller, Frederic, Sadavoy, Sarah, Soler, Juan, Hatchell, Jennifer, Lumsden, Stuart, and Kulesa, Craig
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Astrophysics - Astrophysics of Galaxies - Abstract
The past two decades have seen extensive surveys of the far-infrared to submillimeter continuum emission in the plane of our Galaxy. We line out prospects for the coming decade for corresponding molecular and atomic line surveys which are needed to fully understand the formation of the dense structures that give birth to clusters and stars out of the diffuse interstellar medium. We propose to work towards Galaxy wide surveys in mid-J CO lines to trace shocks from colliding clouds, Galaxy-wide surveys for atomic Carbon lines in order to get a detailed understanding of the relation of atomic and molecular gas in clouds, and to perform extensive surveys of the structure of the dense parts of molecular clouds to understand the importance of filaments/fibers over the full range of Galactic environments and to study how dense cloud cores are formed from the filaments. This work will require a large (50m) Single Dish submillimeter telescope equipped with massively multipixel spectrometer arrays, such as envisaged by the AtLAST project., Comment: Science white paper submitted to the Astro2020 Decadal Survey
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- 2019
182. The hidden circumgalactic medium
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Cicone, Claudia, De Breuck, Carlos, Chen, Chian-Chou, van Kampen, Eelco, Narayanan, Desika, Mroczkowski, Tony, Andreani, Paola, Klaassen, Pamela, Weiss, Axel, Kohno, Kotaro, Kauffmann, Jens, Wagg, Jeff, Riechers, Dominik, Gullberg, Bitten, Geach, James, Shen, Sijing, Hill, J. Colin, and Brownson, Simcha
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Astrophysics - Astrophysics of Galaxies - Abstract
The cycling of baryons in and out of galaxies is what ultimately drives galaxy formation and evolution. The circumgalactic medium (CGM) represents the interface between the interstellar medium and the cosmic web, hence its properties are directly shaped by the baryon cycle. Although traditionally the CGM is thought to consist of warm and hot gas, recent breakthroughs are presenting a new scenario according to which an important fraction of its mass may reside in the cold atomic and molecular phase. This would represent fuel that is readily available for star formation, with crucial implications for feeding and feedback processes in galaxies. However, such cold CGM, especially in local galaxies where its projected size on sky is expected to be of several arcminutes, cannot be imaged by ALMA due to interferometric spatial scale filtering of large-scale structures. We show that the only way to probe the multiphase CGM including its coldest component is through a large (e.g. 50-m) single dish (sub-)mm telescope., Comment: Science white paper submitted to the Astro2020 Decadal Survey
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- 2019
183. Science from an Ultra-Deep, High-Resolution Millimeter-Wave Survey
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Sehgal, Neelima, Nguyen, Ho Nam, Meyers, Joel, Munchmeyer, Moritz, Mroczkowski, Tony, Di Mascolo, Luca, Baxter, Eric, Cyr-Racine, Francis-Yan, Madhavacheril, Mathew, Beringue, Benjamin, Holder, Gil, Nagai, Daisuke, Dicker, Simon, Dvorkin, Cora, Ferraro, Simone, Fuller, George M., Gluscevic, Vera, Han, Dongwon, Jain, Bhuvnesh, Johnson, Bradley, Klaassen, Pamela, Meerburg, Daan, Motloch, Pavel, Spergel, David N., van Engelen, Alexander, Adshead, Peter, Armstrong, Robert, Baccigalupi, Carlo, Barron, Darcy, Basu, Kaustuv, Benson, Bradford, Beutler, Florian, Bond, J. Richard, Borrill, Julian, Calabrese, Erminia, Darwish, Omar, Denny, S. Lucas, Douglass, Kelly A., Essinger-Hileman, Tom, Foreman, Simon, Frayer, David, Gerbino, Martina, Gontcho, Satya Gontcho A, Grohs, Evan B., Gupta, Nikhel, Hill, J. Colin, Hirata, Christopher M., Hotinli, Selim, Johnson, Matthew C., Kamionkowski, Marc, Kovetz, Ely D., Lau, Erwin T., Liguori, Michele, Namikawa, Toshiya, Newburgh, Laura, Partridge, Bruce, Piacentni, Francesco, Rose, Benjamin, Rossi, Graziano, Saliwanchik, Benjamin, Schaan, Emmanuel, Shan, Huanyuan, Simon, Sara, Slosar, Anže, Switzer, Eric R., Trac, Hy, Xu, Weishuang, Zaldarriaga, Matias, and Zemcov, Michael
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,High Energy Physics - Phenomenology - Abstract
Opening up a new window of millimeter-wave observations that span frequency bands in the range of 30 to 500 GHz, survey half the sky, and are both an order of magnitude deeper (about 0.5 uK-arcmin) and of higher-resolution (about 10 arcseconds) than currently funded surveys would yield an enormous gain in understanding of both fundamental physics and astrophysics. In particular, such a survey would allow for major advances in measuring the distribution of dark matter and gas on small-scales, and yield needed insight on 1.) dark matter particle properties, 2.) the evolution of gas and galaxies, 3.) new light particle species, 4.) the epoch of inflation, and 5.) the census of bodies orbiting in the outer Solar System., Comment: 5 pages + references; Submitted to the Astro2020 call for science white papers
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- 2019
184. A High-resolution SZ View of the Warm-Hot Universe
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Mroczkowski, Tony, Nagai, Daisuke, Andreani, Paola, Arnaud, Monique, Bartlett, James, Battaglia, Nicholas, Basu, Kaustuv, Bulbul, Esra, Chluba, Jens, Churazov, Eugene, Cicone, Claudia, Crites, Abigail, DeNigris, Nat, Devlin, Mark, Di Mascolo, Luca, Dicker, Simon, Gaspari, Massimo, Golwala, Sunil, Guglielmetti, Fabrizia, Hill, J. Colin, Klaassen, Pamela, Kitayama, Tetsu, Kneissl, Rüdiger, Kohno, Kotaro, Komatsu, Eiichiro, Lacy, Mark, Mason, Brian, Nyland, Kristina, Romero, Charles, Sayers, Jack, Sehgal, Neelima, Simon, Sara, Sunyaev, Rashid, Wilson, Grant, Zemcov, Michael, and ZuHone, John
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Astrophysics - Cosmology and Nongalactic Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Sunyaev-Zeldovich (SZ) effect was first predicted nearly five decades ago, but has only recently become a mature tool for performing high resolution studies of the warm and hot ionized gas in and between galaxies, groups, and clusters. Galaxy groups and clusters are powerful probes of cosmology, and they also serve as hosts for roughly half of the galaxies in the Universe. In this white paper, we outline the advances in our understanding of thermodynamic and kinematic properties of the warm-hot universe that can come in the next decade through spatially and spectrally resolved measurements of the SZ effects. Many of these advances will be enabled through new/upcoming millimeter/submillimeter (mm/submm) instrumentation on existing facilities, but truly transformative advances will require construction of new facilities with larger fields of view and broad spectral coverage of the mm/submm bands., Comment: 14 pages, 5 figures, Science white paper submitted to the Astro2020 Decadal Survey
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- 2019
185. The Impact of the COVID-19 Pandemic on Genitourinary Cancer Care: Re-envisioning the Future.
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Wallis, Christopher, Catto, James, Finelli, Antonio, Glaser, Adam, Gore, John, Loeb, Stacy, Morgan, Todd, Morgans, Alicia, Mottet, Nicolas, Neal, Richard, OBrien, Tim, Odisho, Anobel, Powles, Thomas, Skolarus, Ted, Smith, Angela, Szabados, Bernadett, Klaassen, Zachary, and Spratt, Daniel
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Biomedical research ,Health services accessibility ,Mental health ,Pandemic ,Telemedicine ,COVID-19 ,Communicable Disease Control ,Coronavirus Infections ,Delivery of Health Care ,Humans ,Mental Health ,Organizational Innovation ,Pandemics ,Pneumonia ,Viral ,Practice Patterns ,Physicians ,Telemedicine ,Urogenital Neoplasms - Abstract
CONTEXT: The coronavirus disease 2019 (COVID-19) pandemic necessitated rapid changes in medical practice. Many of these changes may add value to care, creating opportunities going forward. OBJECTIVE: To provide an evidence-informed, expert-derived review of genitourinary cancer care moving forward following the initial COVID-19 pandemic. EVIDENCE ACQUISITION: A collaborative narrative review was conducted using literature published through May 2020 (PubMed), which comprised three main topics: reduced in-person interactions arguing for increasing virtual and image-based care, optimisation of the delivery of care, and the effect of COVID-19 in health care facilities on decision-making by patients and their families. EVIDENCE SYNTHESIS: Patterns of care will evolve following the COVID-19 pandemic. Telemedicine, virtual care, and telemonitoring will increase and could offer broader access to multidisciplinary expertise without increasing costs. Comprehensive and integrative telehealth solutions will be necessary, and should consider patients mental health and access differences due to socioeconomic status. Investigations and treatments will need to maximise efficiency and minimise health care interactions. Solutions such as one stop clinics, day case surgery, hypofractionated radiotherapy, and oral or less frequent drug dosing will be preferred. The pandemic necessitated a triage of those patients whose treatment should be expedited, delayed, or avoided, and may persist with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in circulation. Patients whose demographic characteristics are at the highest risk of complications from COVID-19 may re-evaluate the benefit of intervention for less aggressive cancers. Clinical research will need to accommodate virtual care and trial participation. Research dissemination and medical education will increasingly utilise virtual platforms, limiting in-person professional engagement; ensure data dissemination; and aim to enhance patient engagement. CONCLUSIONS: The COVID-19 pandemic will have lasting effects on the delivery of health care. These changes offer opportunities to improve access, delivery, and the value of care for patients with genitourinary cancers but raise concerns that physicians and health administrators must consider in order to ensure equitable access to care. PATIENT SUMMARY: The coronavirus disease 2019 (COVID-19) pandemic has dramatically changed the care provided to many patients with genitourinary cancers. This has necessitated a transition to telemedicine, changes in threshold or delays in many treatments, and an opportunity to reimagine patient care to maintain safety and improve value moving forward.
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- 2020
186. Impact of Diagnosing Urologists and Hospitals on the Use of Radical Cystectomy
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Golla, Vishnukamal, Shan, Yong, Mehta, Hemalkumar B, Klaassen, Zachary, Tyler, Douglas S, Baillargeon, Jacques, Kamat, Ashish M, Freedland, Stephen J, Gore, John L, Chamie, Karim, Kuo, Yong-Fang, and Williams, Stephen B
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Cancer ,Urologic Diseases ,Bladder cancer ,Radical cystectomy ,Variation ,Utilization ,Urology & Nephrology ,Clinical sciences - Abstract
BackgroundOne out of five patients with muscle-invasive bladder cancer undergo radical cystectomy-a guideline-recommended treatment. Previous studies have primarily evaluated patient characteristics associated with the use of radical cystectomy, ignoring potential nesting of data.ObjectiveTo determine the impact of patient, diagnosing urologist, and hospital characteristics on the variation in the use of radical cystectomy.Design setting and participantsThis is a retrospective cohort study using the Surveillance, Epidemiology, and End Results Registry (SEER)-Medicare linked database.Outcome measurements and statistical analysisA total of 7097 muscle-invasive bladder cancer patients and 4601 diagnosing urologists affiliated to 822 hospitals from January 1, 2002 to December 31, 2012 were analyzed. Multilevel logistic regression analyses were used to determine variation and factors associated with the use of radical cystectomy.Results and limitationsOf the 7097 patients, only 27% underwent radical cystectomy. The intraclass correlation coefficient for variation in the use of radical cystectomy attributed to the hospital level was 4.3%. Higher radical cystectomy volume by diagnosing urologists (more than five vs zero to one surgery: odds ratio [OR], 1.27; 95% confidence interval [CI], 1.00-1.62) and hospitals (more than five vs zero to four surgeries: OR,1.48; 95% CI, 1.14-1.93) was associated with increased use of radical cystectomy. Patients diagnosed by female rather than male urologists were more likely to undergo radical cystectomy (OR, 1.32; 95% CI, 1.07-1.62).ConclusionsWe found that 4.3% variation in the use of radical cystectomy was attributed to the hospital level, leaving 95.7% variation in use unexplained. We identified significantly increased use among higher-volume and female diagnosing urologists. These findings support further investigation into measures beyond hospital volume, which largely impact the utilization of radical cystectomy.Patient summaryIn this large population-based study, we found that 4.3% of variation in the use of radical cystectomy was attributed to the hospital level, leaving 95.7% variation in use unexplained. Higher radical cystectomy volume of diagnosing urologists and female urologists were independently associated with increased use of radical cystectomy. These findings support further investigation into measures beyond hospital volume, which largely impact the utilization of radical cystectomy.
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- 2020
187. IMPACT OF DIAGNOSING UROLOGISTS AND HOSPITALS ON USE OF RADICAL CYSTECTOMY
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Golla, Vishnukamal, Shan, Yong, Mehta, Hemalkumar, Klaassen, Zachary, Tyler, Douglas, Baillaregon, Jacques, Kamat, Ashish, Freedland, Stephen, Gore, John, Kerr, Preston, Chamie, Karim, Kuo, Yong-Fang, and Williams, Stephen
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Urology & Nephrology ,Clinical Sciences - Published
- 2020
188. Polyandry and non-random fertilisation maintain long-term genetic diversity in an isolated island population of adders (Vipera berus)
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Madsen, Thomas, Ujvari, Beata, Bauwens, Dirk, Gruber, Bernd, Georges, Arthur, and Klaassen, Marcel
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- 2023
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189. Should I stay, should I go, or something in between? The potential for parasite-mediated and age-related differential migration strategies
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Wille, Michelle and Klaassen, Marcel
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- 2023
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190. Meta-analysis on necessary investment shifts to reach net zero pathways in Europe
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Klaaßen, Lena and Steffen, Bjarne
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- 2023
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191. Prostate cancer mortality rates in low- and favorable intermediate-risk active surveillance patients: a population-based competing risks analysis
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Sayyid, Rashid K., Benton, John Z., Reed, William C., Woodruff, Phillip, Terris, Martha K., Wallis, Christopher J. D., and Klaassen, Zachary
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- 2023
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192. Normalization of Cardiac Function After Bariatric Surgery Is Related to Autonomic Function and Vitamin D
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Snelder, Sanne M., Aga, Yaar, de Groot - de Laat, Lotte E., Biter, L. Ulas, Cabezas, Manuel Castro, Pouw, Nadine, Birnie, Erwin, Boxma - de Klerk, Bianca, Klaassen, René A., Zijlstra, Felix, and van Dalen, Bas M.
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- 2023
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193. Added value of 3T MRI and the MRI-halo sign in assessing resectability of locally advanced pancreatic cancer following induction chemotherapy (IMAGE-MRI): prospective pilot study
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Stoop, Thomas F., van Veldhuisen, Eran, van Rijssen, L. Bengt, Klaassen, Remy, Gurney-Champion, Oliver J., de Hingh, Ignace H., Busch, Olivier R., van Laarhoven, Hanneke W. M., van Lienden, Krijn P., Stoker, Jaap, Wilmink, Johanna W., Nio, C. Yung, Nederveen, Aart J., Engelbrecht, Marc R. W., and Besselink, Marc G.
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- 2022
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194. Deep Learning How to Fit an Intravoxel Incoherent Motion Model to Diffusion-Weighted MRI
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Barbieri, Sebastiano, Gurney-Champion, Oliver J., Klaassen, Remy, and Thoeny, Harriet C.
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Quantitative Biology - Quantitative Methods ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Image and Video Processing - Abstract
Purpose: This prospective clinical study assesses the feasibility of training a deep neural network (DNN) for intravoxel incoherent motion (IVIM) model fitting to diffusion-weighted magnetic resonance imaging (DW-MRI) data and evaluates its performance. Methods: In May 2011, ten male volunteers (age range: 29 to 53 years, mean: 37 years) underwent DW-MRI of the upper abdomen on 1.5T and 3.0T magnetic resonance scanners. Regions of interest in the left and right liver lobe, pancreas, spleen, renal cortex, and renal medulla were delineated independently by two readers. DNNs were trained for IVIM model fitting using these data; results were compared to least-squares and Bayesian approaches to IVIM fitting. Intraclass Correlation Coefficients (ICC) were used to assess consistency of measurements between readers. Intersubject variability was evaluated using Coefficients of Variation (CV). The fitting error was calculated based on simulated data and the average fitting time of each method was recorded. Results: DNNs were trained successfully for IVIM parameter estimation. This approach was associated with high consistency between the two readers (ICCs between 50 and 97%), low intersubject variability of estimated parameter values (CVs between 9.2 and 28.4), and the lowest error when compared with least-squares and Bayesian approaches. Fitting by DNNs was several orders of magnitude quicker than the other methods but the networks may need to be re-trained for different acquisition protocols or imaged anatomical regions. Conclusion: DNNs are recommended for accurate and robust IVIM model fitting to DW-MRI data. Suitable software is available at (1).
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- 2019
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195. Ervaren mentaal welzijn door adolescenten tijdens de COVID-19-pandemie: Ik denk aan jou, jij ook aan mij?
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Lobbezoo, A., Klaassen, T., and de Bot, Cindy
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- 2022
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196. Kardiomyopathie im Neugeborenenalter: Forschungsfortschritte eröffnen neue diagnostische Möglichkeiten
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Frenzel, M., Klaassen, S., Klingel, K., Knirsch, W., Kretschmar, O., Kühnisch, J., and Oxenius, A.
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- 2022
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197. Chasing discs around O-type (proto)stars - ALMA evidence for an SiO disc and disc wind from G17.64+0.16
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Maud, L. T., Cesaroni, R., Kumar, M. S. N., van der Tak, F. F. S., Allen, V., Hoare, M. G., Klaassen, P. D., Harsono, D., Hogerheijde, M. R., Sánchez-Monge, Á., Schilke, P., Ahmadi, A., Beltrán, M. T., Beuther, H., Csengeri, T., Etoka, S., Fuller, G., Galván-Madrid, R., Goddi, C., Henning, Th., Johnston, K. G., Kuiper, R., Lumsden, S., Moscadelli, L., Mottram, J. C., Peters, T., Rivilla, V. M., Testi, L., Vig, S., de Wit, W. J., and Zinnecker, H.
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We present high angular resolution 0.2 arcsec continuum and molecular emission line Atacama Large Millimeter/sub-millimeter Array (ALMA) observations of G17.64+0.16 in Band 6 (220GHz) taken as part of a campaign in search of circumstellar discs around (proto)-O-stars. At a resolution of 400au the main continuum core is essentially unresolved and isolated from other strong and compact emission peaks. At a resolution of 400au the main continuum core is essentially unresolved and isolated from other strong and compact emission peaks. We detect SiO (5-4) emission that is marginally resolved and elongated in a direction perpendicular to the large-scale outflow seen in the 13CO (2-1) line using the main ALMA array in conjunction with the Atacama Compact Array (ACA). Morphologically, the SiO appears to represent a disc-like structure. Using parametric models we show that the position-velocity profile of the SiO is consistent with the Keplerian rotation of a disc around an object between 10-30Mo in mass, only if there is also radial expansion from a separate structure. The radial motion component can be interpreted as a disc wind from the disc surface. Models with a central stellar object mass between 20 and 30Mo are the most consistent with the stellar luminosity (100000 Lo) and indicative of an O-type star. The H30a millimetre recombination line (231.9GHz) is also detected, but spatially unresolved, and is indicative of a very compact, hot, ionised region co-spatial with the dust continuum core. Accounting for all observables, we suggest that G17.64 is consistent with a O-type young stellar object in the final stages of protostellar assembly, driving a wind, but that has not yet developed into a compact HII region. The existance and detection of the disc in G17.64 is likely related to its isolated and possibly more evolved nature, traits which may underpin discs in similar sources., Comment: 23 pages, 13 fig (inc 3 Appendix figures)
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- 2018
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198. Uniform Inference in High-Dimensional Gaussian Graphical Models
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Klaassen, Sven, Kück, Jannis, Spindler, Martin, and Chernozhukov, Victor
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Statistics - Methodology ,Computer Science - Machine Learning ,Economics - Econometrics ,Statistics - Machine Learning ,62H15, 62J07 - Abstract
Graphical models have become a very popular tool for representing dependencies within a large set of variables and are key for representing causal structures. We provide results for uniform inference on high-dimensional graphical models with the number of target parameters $d$ being possible much larger than sample size. This is in particular important when certain features or structures of a causal model should be recovered. Our results highlight how in high-dimensional settings graphical models can be estimated and recovered with modern machine learning methods in complex data sets. To construct simultaneous confidence regions on many target parameters, sufficiently fast estimation rates of the nuisance functions are crucial. In this context, we establish uniform estimation rates and sparsity guarantees of the square-root estimator in a random design under approximate sparsity conditions that might be of independent interest for related problems in high-dimensions. We also demonstrate in a comprehensive simulation study that our procedure has good small sample properties., Comment: 59 pages, 2 figures, 6 tables
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- 2018
199. Core fragmentation and Toomre stability analysis of W3(H2O): A case study of the IRAM NOEMA large program CORE
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Ahmadi, A., Beuther, H., Mottram, J. C., Bosco, F., Linz, H., Henning, Th., Winters, J. M., Kuiper, R., Pudritz, R., Sánchez-Monge, Á., Keto, E., Beltran, M., Bontemps, S., Cesaroni, R., Csengeri, T., Feng, S., Galvan-Madrid, R., Johnston, K. G., Klaassen, P., Leurini, S., Longmore, S. N., Lumsden, S., Maud, L. T., Menten, K. M., Moscadelli, L., Motte, F., Palau, A., Peters, T., Ragan, S. E., Schilke, P., Urquhart, J. S., Wyrowski, F., and Zinnecker, H.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
The fragmentation mode of high-mass molecular clumps and the properties of the central rotating structures surrounding the most luminous objects have yet to be comprehensively characterised. Using the IRAM NOrthern Extended Millimeter Array (NOEMA) and the IRAM 30-m telescope, the CORE survey has obtained high-resolution observations of 20 well-known highly luminous star-forming regions in the 1.37 mm wavelength regime in both line and dust continuum emission. We present the spectral line setup of the CORE survey and a case study for W3(H2O). At ~0.35" (700 AU at 2 kpc) resolution, the W3(H2O) clump fragments into two cores (West and East), separated by ~2300 AU. Velocity shifts of a few km/s are observed in the dense-gas tracer, CH3CN, across both cores, consistent with rotation and perpendicular to the directions of two bipolar outflows, one emanating from each core. The kinematics of the rotating structure about W3(H2O) W shows signs of differential rotation of material, possibly in a disk-like object. The observed rotational signature around W3(H2O) E may be due to a disk-like object, an unresolved binary (or multiple) system, or a combination of both. We fit the emission of CH3CN (12-11) K = 4-6 and derive a gas temperature map with a median temperature of ~165 K across W3(H2O). We create a Toomre Q map to study the stability of the rotating structures against gravitational instability. The rotating structures appear to be Toomre unstable close to their outer boundaries, with a possibility of further fragmentation in the differentially-rotating core W3(H2O) W. Rapid cooling in the Toomre-unstable regions supports the fragmentation scenario. Combining millimeter dust continuum and spectral line data toward the famous high-mass star-forming region W3(H2O), we identify core fragmentation on large scales, and indications for possible disk fragmentation on smaller spatial scales., Comment: 23 pages, 26 figures, accepted for publication in Astronomy and Astrophysics
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- 2018
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200. Fragmentation and disk formation during high-mass star formation: The IRAM NOEMA (Northern Extended Millimeter Array) large program CORE
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Beuther, H., Mottram, J. C., Ahmadi, A., Bosco, F., Linz, H., Henning, Th., Klaassen, P., Winters, J. M., Maud, L. T., Kuiper, R., Semenov, D., Gieser, C., Peters, T., Urquhart, J. S., Pudritz, R., Ragan, S. E., Feng, S., Keto, E., Leurini, S., Cesaroni, R., Beltran, M., Palau, A., Sanchez-Monge, A., Galvan-Madrid, R., Zhang, Q., Schilke, P., Wyrowski, F., Johnston, K. G., Longmore, S. N., Lumsden, S., Hoare, M., Menten, K. M., and Csengeri, T.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Aims: We aim to understand the fragmentation as well as the disk formation, outflow generation and chemical processes during high-mass star formation on spatial scales of individual cores. Methods: Using the IRAM Northern Extended Millimeter Array (NOEMA) in combination with the 30m telescope, we have observed in the IRAM large program CORE the 1.37mm continuum and spectral line emission at high angular resolution (~0.4'') for a sample of 20 well-known high-mass star-forming regions with distances below 5.5kpc and luminosities larger than 10^4Lsun. Results: We present the overall survey scope, the selected sample, the observational setup and the main goals of CORE. Scientifically, we concentrate on the mm continuum emission on scales on the order of 1000AU. We detect strong mm continuum emission from all regions, mostly due to the emission from cold dust. The fragmentation properties of the sample are diverse. We see extremes where some regions are dominated by a single high-mass core whereas others fragment into as many as 20 cores. A minimum-spanning-tree analysis finds fragmentation at scales on the order of the thermal Jeans length or smaller suggesting that turbulent fragmentation is less important than thermal gravitational fragmentation. The diversity of highly fragmented versus singular regions can be explained by varying initial density structures and/or different initial magnetic field strengths. Conclusions: The smallest observed separations between cores are found around the angular resolution limit which indicates that further fragmentation likely takes place on even smaller spatial scales. The CORE project with its numerous spectral line detections will address a diverse set of important physical and chemical questions in the field of high-mass star formation., Comment: 29 pages, 17 figures, Astronomy & Astrophysics in press, for a higher-resolution version of the paper see http://www.mpia.de/homes/beuther/papers.html
- Published
- 2018
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