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154. We need better pediatric cardiac transplantation risk modeling

Author

Woods, Ronald K., primary, Kirklin, James K., additional, Maeda, Katsuhide, additional, Adachi, Iki, additional, Davies, Ryan R., additional, Morales, David, additional, Ma, Michael, additional, Jaquiss, Robert D.B., additional, Gaynor, William, additional, Kindel, Steven J., additional, and Rossano, Joseph W., additional

Published
2022
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162. Generalizability of Trial Data to Real-World Practice: An Analysis of The Society of Thoracic Surgeons Intermacs Database

Author

Brescia, Alexander A., primary, Watt, Tessa M.F., additional, Pagani, Francis D., additional, Cascino, Thomas M., additional, Zhang, Min, additional, McCullough, Jeffrey S., additional, Shore, Supriya, additional, Likosky, Donald S., additional, Aaronson, Keith D., additional, Cantor, Ryan S., additional, Deng, Luqin, additional, Kirklin, James K., additional, and Thompson, Michael P., additional

Published
2022
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163. Health-Related Quality of Life in Older Patients With Heart Failure From Before to Early After Advanced Surgical Therapies: Findings From the SUSTAIN-IT Study

Author

Grady, Kathleen L., primary, Kao, Andrew, additional, Spertus, John A., additional, Hsich, Eileen, additional, Dew, Mary Amanda, additional, Pham, Duc-Thinh, additional, Hartupee, Justin, additional, Petty, Michael, additional, Cotts, William, additional, Pamboukian, Salpy V., additional, Pagani, Francis D., additional, Lampert, Brent, additional, Johnson, Maryl, additional, Murray, Margaret, additional, Takeda, Koji, additional, Yuzefpolskaya, Melana, additional, Silvestry, Scott, additional, Kirklin, James K., additional, Andrei, Adin-Cristian, additional, Elenbaas, Christian, additional, Baldridge, Abigail, additional, and Yancy, Clyde, additional

Published
2022
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165. Prolonged hospital length of stay after pediatric heart transplantation: A machine learning and logistic regression predictive model from the Pediatric Heart Transplant Society

Author

Gupta, Dipankar, primary, Bansal, Neha, additional, Jaeger, Byron C., additional, Cantor, Ryan C., additional, Koehl, Devin, additional, Kimbro, Allison K, additional, Castleberry, Chesney D., additional, Pophal, Stephen G., additional, Asante-Korang, Alfred, additional, Schowengerdt, Kenneth, additional, Kirklin, James K., additional, and Sutcliffe, David L., additional

Published
2022
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176. Causes and Consequences of Missing Health-Related Quality of Life Assessments in Patients Who Undergo Mechanical Circulatory Support Implantation: Insights From INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support)

Author

Grady, Kathleen L., Jones, Philip G., Cristian-Andrei, Adin, Naftel, David C., Myers, Susan, Dew, Mary Amanda, Idrissi, Katharine, Weidner, Gerdi, Wissman, Sherri A., Kirklin, James K., and Spertus, John A.

Published
2017
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178. Hospital Mortality and Adverse Events Following Repair of Congenital Heart Defects in Developing Countries

Author

Bateson, Brian P., Deng, Luqin, Ange, Brittany, Austin, Erle, Dabal, Robert, Broser, Taylor, Pennington, John, Sivakumar, Sivalingam, Lee, Cheul, Truong, Nguyen Ly Thinh, Jacobs, Jeffery P., Cervantes, Jorge, Kirklin, James K., and St. Louis, James

Abstract

Background Mortality associated with the correction of congenital heart disease has decreased to approximately 2% in developed countries and major adverse events are uncommon. Outcomes in developing countries are less well defined. The World Database for Pediatric and Congenital Heart Surgery was utilized to compare mortality and adverse events in developed and developing countries.Methods A total of 16,040 primary procedures were identified over a two-year period. Centers that submitted procedures were dichotomized to low/middle income (LMI) and high income (HI) by the Gross National Income per capita categorization. Mortality was defined as any death following the primary procedure to discharge or 90 days inpatient. Multiple logistic regression models were utilized to identify independent predictors of mortality.Results Of the total number of procedures analyzed, 83% (n  =  13,294) were from LMI centers. Among all centers, the mean age at operation was 2.2 years, with 36% (n  =  5,743) less than six months; 85% (n  =  11,307) of procedures were STAT I/II for LMI centers compared with 77% (n = 2127) for HI centers (P< .0001). Overall mortality across the cohort was 2.27%. There was a statistical difference in mortality between HI centers (0.55%) versus LMI centers (2.64%) (P< .0001). After adjustment for other risk factors, the risk of death remained significantly higher in LMI centers (odds ratio: 2.36, 95% confidence interval: 1.707-3.27).Conclusion Although surgical expertise has increased across the globe, there remains a disparity with some outcomes associated with the correction of congenital heart disease between developing and developed countries. Further studies are needed to identify specific opportunities for improvement.

Published
2023
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179. The Academic Impact of Congenital Heart Surgeons’ Society (CHSS) Studies

Author

Jacobs, Jeffrey Phillip, DeCampli, William M., Karamlou, Tara, Najm, Hani K., Marino, Bradley S., Blackstone, Eugene H., McCrindle, Brian W., Jegatheeswaran, Anusha, St. Louis, James D., Austin, Erle H., Caldarone, Christopher A., Mavroudis, Constantine, Overman, David M., Dearani, Joseph A., Jacobs, Marshall L., Tchervenkov, Christo I., Svensson, Lars G., Barron, David, Kirklin, James K., and Williams, William G.

Abstract

Purpose We reviewed all 64 articles ever published by The Congenital Heart Surgeons’ Society (CHSS) Data Center to estimate the academic impact of these peer-reviewed articles.Materials and Methods The Congenital Heart Surgeons’ Society has performed research based on 12 Diagnostic Inception Cohorts. The first cohort (Transposition) began enrolling patients on January 1, 1985. We queried PubMed to determine the number of publications that referenced each of the 64 journal articles generated by the datasets of the 12 Diagnostic Inception Cohorts that comprise the CHSS Database. Descriptive summaries of the data were tabulated using mean with standard deviation and median with range.Results Sixty-four peer-reviewed papers have been published based on the CHSS Database. Fifty-nine peer-reviewed articles have been published based on the 12 Diagnostic Inception Cohorts, and five additional articles have been published based on Data Science. Excluding the recently established Diagnostic Inception Cohort for patients with Ebstein malformation of tricuspid valve, the number of papers published per cohort ranged from 1 for coarctation to 11 for transposition of the great arteries. The 11 articles generated from the CHSS Transposition Cohort were referenced by a total of 111 articles (median number of references per journal article = 9 [range = 0-22, mean = 10.1]). Overall, individual articles were cited by an average of 11 (mean), and a maximum of 41 PubMed-listed publications. Overall, these 64 peer-reviewed articles based on the CHSS Database were cited 692 times in PubMed-listed publications. The first CHSS peer-reviewed article was published in 1987, and during the 35 years from 1987 to 2022, inclusive, the annual number of CHSS publications has ranged from 0 to 7, with a mean of 1.8 publications per year (median = 1, mode = 1).Conclusion Congenital Heart Surgeons’ Society studies are widely referenced in the pediatric cardiac surgical literature, with over 10 citations per published article. These cohorts provide unique information unavailable in other sources of data. A tool to access this analysis is available at: [https://data-center.chss.org/multimedia/files/2022/CAI.pdf].

Published
2023
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180. John Kirklin's Impact on the Origins of Open Heart Surgery and the Congenital Heart Surgeons' Society

Author

Kirklin, James K.

Abstract

John Kirklin stands out as one of the surgeons most identifiably responsible for bringing the field of open heart surgery to clinical reality and initiating scientific pursuits in the Congenital Heart Surgeons' Society. His accomplishments are perhaps best viewed in the context of other major contributions made by researchers and fellow surgeons, which collectively positioned Kirklin and other cardiac surgery pioneers to usher in the dawn of open heart surgery and later the Congenital Heart Surgeons' Society.

Published
2023
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185. Right Heart Failure Following Left Ventricular Device Implantation: Natural History, Risk Factors, and Outcomes: An Analysis of the STS INTERMACS Database

Author

Kapelios, Chris J., primary, Lund, Lars H., additional, Wever-Pinzon, Omar, additional, Selzman, Craig H., additional, Myers, Susan L., additional, Cantor, Ryan S., additional, Stehlik, Josef, additional, Chamogeorgakis, Themistocles, additional, McKellar, Stephen H., additional, Koliopoulou, Antigone, additional, Alharethi, Rami, additional, Kfoury, Abdallah G., additional, Bonios, Michael, additional, Adamopoulos, Stamatis, additional, Gilbert, Edward M., additional, Fang, James C., additional, Kirklin, James K., additional, and Drakos, Stavros G., additional

Published
2022
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195. Early Right Ventricular Assist Device Use in Patients Undergoing Continuous-Flow Left Ventricular Assist Device Implantation: Incidence and Risk Factors From the Interagency Registry for Mechanically Assisted Circulatory Support

Author

Kiernan, Michael S., Grandin, E. Wilson, Brinkley, Marshall, Jr, Kapur, Navin K., Pham, Duc Thinh, Ruthazer, Robin, Rame, J. Eduardo, Atluri, Pavan, Birati, Edo Y., Oliveira, Guilherme H., Pagani, Francis D., Kirklin, James K., Naftel, David, Kormos, Robert L., Teuteberg, Jeffrey J., and DeNofrio, David

Published
2017
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197. Loss of pulsatility with continuous‐flow left ventricular assist devices and the significance of the arterial endothelium in von‐Willebrand factor production and degradation.

Author

Giridharan, Guruprasad A., Berg, Ian C., Ismail, Esraa, Nguyen, Khanh T., Hecking, Jana, Kirklin, James K., Cheng, Xuanhong, and Sethu, Palaniappan

Subjects
HEART assist devices, ENDOTHELIAL cells, FACTORS of production, VON Willebrand factor, ENDOTHELIUM, PULSATILE flow
Abstract

Background: Patients on continuous flow ventricular assist devices (CF‐VADs) are at high risk for the development of Acquired von‐Willebrand Syndrome (AVWS) and non‐surgical bleeding. von Willebrand Factor (vWF) plays an essential role in maintaining hemostasis via platelet binding to the damaged endothelium to facilitate coagulation. In CF‐VAD patients, degradation of vWF into low MW multimers that are inefficient in facilitating coagulation occurs and has been primarily attributed to the supraphysiological shear stress associated with the CF‐VAD impeller. Methods: In this review, we evaluate information from the literature regarding the unraveling behavior of surface‐immobilized vWF under pulsatile and continuous flow pertaining to: (A) the process of arterial endothelial vWF production and release into circulation, (B) the critical shear stress required to unravel surface bound versus soluble vWF which leads to degradation, and (C) the role of pulsatility in on the production and degradation of vWF. Results and Conclusion: Taken together, these data suggests that the loss of pulsatility and its impact on arterial endothelial cells plays an important role in the production, release, unraveling, and proteolytic degradation of vWF into low MW multimers, contributing to the development of AVWS. Restoration of pulsatility can potentially mitigate this issue by preventing AVWS and minimizing the risk of non‐surgical bleeding. [ABSTRACT FROM AUTHOR]

Published
2023
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199. Proceedings from the metrics forum in heart transplantation for performance monitoring

Author

Kobashigawa, Jon A., primary, Hall, Shelley, additional, Farr, Maryjane, additional, Blumberg, Emily, additional, Michael Borkon, A., additional, Colvin, Monica, additional, Copeland, Hannah, additional, Eisen, Howard, additional, Johnson, Maryl, additional, Jorde, Ulrich, additional, Khush, Kiran, additional, Kirklin, James K., additional, Patel, Jignesh, additional, Pinney, Sean, additional, Saadaeijahromi, Hannaneh, additional, Schold, Jesse D., additional, and Stehlik, Josef, additional

Published
2022
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200. Heart transplantation using donation after circulatory death in the United States

Author

Chen, Qiudong, primary, Emerson, Dominic, additional, Megna, Dominick, additional, Osho, Asishana, additional, Roach, Amy, additional, Chan, Joshua, additional, Rowe, Georgina, additional, Gill, George, additional, Esmailian, Fardad, additional, Chikwe, Joanna, additional, Egorova, Natalia, additional, Kirklin, James K., additional, Kobashigawa, Jon, additional, and Catarino, Pedro, additional

Published
2022
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