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151. Possible clearance of transfusion-acquired nef/LTR-deleted attenuated HIV-1 infection by an elite controller with CCR5 Δ32 heterozygous and HLA-B57 genotype

Author

Zaunders, John, primary, Dyer, Wayne B., additional, Churchill, Melissa, additional, Munier, C Mee Ling, additional, Cunningham, Philip H., additional, Suzuki, Kazuo, additional, McBride, Kristin, additional, Hey-Nguyen, Will, additional, Koelsch, Kersten, additional, Wang, Bin, additional, Hiener, Bonnie, additional, Palmer, Sarah, additional, Gorry, Paul R., additional, Bailey, Michelle, additional, Xu, Yin, additional, Danta, Mark, additional, Seddiki, Nabila, additional, Cooper, David A., additional, Saksena, Nitin K., additional, Sullivan, John S., additional, Riminton, Sean, additional, Learmont, Jenny, additional, and Kelleher, Anthony D., additional

Published
2019
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152. HIV-1 DNA Is Maintained in Antigen-Specific CD4+ T Cell Subsets in Patients on Long-Term Antiretroviral Therapy Regardless of Recurrent Antigen Exposure

Author

Hey-Nguyen, William J., primary, Bailey, Michelle, additional, Xu, Yin, additional, Suzuki, Kazuo, additional, Van Bockel, David, additional, Finlayson, Robert, additional, Leigh Brown, Andrew, additional, Carr, Andrew, additional, Cooper, David A., additional, Kelleher, Anthony D., additional, Koelsch, Kersten K., additional, and Zaunders, John J., additional

Published
2019
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157. Altered Immune Reconstitution in Allogeneic Stem Cell Transplant Recipients With Human Immunodeficiency Virus (HIV).

Author

Murray, Daniel D, Zaunders, John, Milliken, Samuel T, Munier, C Mee Ling, Ford, Carole, Morrissey, C Orla, Visweswaran, Malini, Avery, Sharon, Sasadeusz, Joseph, Kwan, John, Desai, Shrinivas, Law, Matthew, Koelsch, Kersten K, Lewin, Sharon R, Moore, John, Kelleher, Anthony D, and Polizzotto, Mark N

Subjects
HIV-positive persons, FLOW cytometry, IMMUNE system, HEALING, LEUKEMIA, HEMATOPOIETIC stem cell transplantation, T cells, LYMPHOMAS
Abstract

Background Persons living with human immunodeficiency virus (HIV) are at elevated risk of developing the malignant diseases that require allogeneic stem cell transplantation (ASCT). Recent data suggest that these individuals are also at an elevated risk of certain complications post-ASCT. This risk may result from preexisting HIV-related factors affecting dynamics of immune reconstitution post-ASCT. However, to date, there has been little work describing the dynamics of immune reconstitution post-ASCT in persons with HIV and none comparing these data to controls without HIV. Methods We assessed T-cell reconstitution in 6 ASCT with HIV recipients (HIV+ASCT) compared to a control population of 21 ASCT without HIV recipients. In a subset of HIV+ASCT recipients we performed additional flow cytometry profiling of CD8+ T-cell subsets and antigen specificity of reconstituting CD4+ and CD8+ T cells. Results We observe no difference in post-ASCT CD4+ T cells between HIV+ASCT and HIV-negative ASCT recipients, despite much lower pre-ASCT CD4+ T-cell counts in the HIV+ASCT group. In contrast, we observed significantly higher CD8+ T-cell numbers in the HIV+ASCT group post-ASCT. The reconstituting CD8+ T-cells were predominantly CD45RO+, whereas homing markers and antigen specificity of these cells varied between participants. Conclusion This study represents the most extensive characterization of immune-reconstitution post-ASCT in persons with HIV, and the first to our knowledge to compare these data to ASCT controls without HIV. The results indicate that immune reconstitution in this group can be affected by preexisting HIV infection and post-ASCT antigen exposure. [ABSTRACT FROM AUTHOR]

Published
2021
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158. Mechanisms for Controlling HIV-1 Infection: A Gene Therapy Approach

Author

Ognenovska, Katherine, Klemm, Vera, Ledger, Scott, Turville, Stuart, Symonds, Geoff, Kelleher, Anthony D., Ahlenstiel, Chantelle L., Ognenovska, Katherine, Klemm, Vera, Ledger, Scott, Turville, Stuart, Symonds, Geoff, Kelleher, Anthony D., and Ahlenstiel, Chantelle L.

Abstract

Current anti-retroviral treatment (ART) for HIV-1 is highly effectively at controlling the infection. However, during early infection the virus establishes a latent reservoir, which is not impacted by ART. Any treatment interruption rapidly results in virus rebound from the latent reservoir to pre-therapy levels and thus ART does not constitute an HIV-1 cure. Alternate treatments are currently being explored in the form of gene therapy, following the success of the Berlin patient who has had undetectable virus since 2007. This review will describe the contrasting cure approaches that are currently the focus of multiple studies to control HIV, then focus in on functional cure gene therapy strategies; specifically, epigenetic silencing of HIV-1 by various methods, including RNA-directed transcriptional gene silencing. The various delivery strategies for targeting cells of the latent reservoir will be reviewed and finally, the clinical status and current challenges for ex vivo versus in vivo gene therapy delivery approaches will be discussed.

Published
2018
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159. Impact of allogeneic hematopoietic stem cell transplantation on the HIV reservoir and immune response in three HIV infected individuals

Author

Koelsch, Kersten K, Rasmussen, T A, Hey-Nguyen, W J, Pearson, C. P., Xu, Y, Bailey, M, Marks, K H, Sasson, S C, Taylor, Martin S., Tantau, R, Obeid, S, Milner, B, Morrissey, C O, Pinto, A N, Suzuki, K, Busch, M P, Keating, S M, Kaiser, P., Yukl, S, Wong, J K, Hiener, B M, Palmer, S, Zaunders, J, Post, Jan Andries, Chan, D J, Avery, S, Milliken, S T, Kelleher, Anthony D, Lewin, Sharon R, and Cooper, D A

Subjects
surgical procedures, operative, Journal Article
Abstract

BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to significant changes to the HIV reservoir and HIV immune responses, indicating that further characterisation of HIV infected patients undergoing HSCT is warranted.METHODS: We studied three patients who underwent HSCT after either reduced intensity conditioning or myeloablative conditioning regimen. We measured HIV antigens and antibodies (Ag/Ab), HIV specific CD4+ T cell responses, HIV RNA and DNA in plasma, peripheral blood mononuclear cells (PBMCs), isolated CD4+ T cells from peripheral blood and lymph node cells. The patients remained on ART throughout the follow up period.RESULTS: All patients have been in continued remission for 4-6 years post-HSCT. Analyses of HIV RNA and DNA levels showed substantial reductions in HIV reservoir related measurements in all three patients, changes in immune response varied with pronounced reductions in two patients and a less dramatic reduction in one patient. One patient experienced unexpected viral rebound 4 years after HSCT.CONCLUSION: These three cases highlight the substantial changes to the HIV reservoir and the HIV immune response in patients undergoing allogeneic HSCT. The viral rebound observed in one patient indicates that replication competent HIV can re-emerge several years following HSCT despite these marked changes.

Published
2017
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163. Obituary

Author

Kelleher, Anthony D., primary, Bamford, Lucienne, additional, Draganic, Daren, additional, and Kaldor, John, additional

Published
2018
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165. Contributors

Author

Aguirrebarrena, Gonzalo, Alford, Judy, Arendts, Glenn, Arunanthy, Shalini, Ballard, Neil, Berry, Melinda, Blake, Sophie, Brown, Professor Anthony FT, Byrne, Bonita, Byrne, Mark, Croker, Bill, Delaney, Michael R, Deweerd, Pauline, Dunjey, Stephen, Edwards, Rob, Foltyn, Peter, Foster, Lesley, Fulde, Gordian W O, Fulde, Sascha, Fulde, Tiffany, Gaetani, Daniel, Gawthorne, Julie, Gillett, Mark, Green, Jessica, Green, Tim, Jahromi, Shahrzad, Huber, Jackie, Huddle, Nadine, Jazayeri, Farzad, Kelleher, Anthony D, Lee, Marian, Leung, Julie, Louey, Derek, Maruno, Kevin, McDonald, Greg, Macdonald, Stephen, Mobbs, Chris, Murphy, David, O’Connor, Alicia, Orr, Andrew, Orr, Bronwyn, Park, Edmond, Phan, Kevin, Raftos, John, Rao, Arjun, Richardson, Drew, Roberts, John, Robinson, Kent, Saccasan, Patricia, Samarasinghe, Iromi, Santram, Rahul, Sasson, Sarah C, Sebaratnam, Deshan, Seelan, E S, Sellors, Kate, Smialkowski, Ania, Spencer, Emma, Stevens, Jennifer, Sullivan, Richard, Tankel, Alan, Tietze, Tad, Varndell, Wayne, Vinen, John, Walsh, Rebecca, Whelan, Anthony, Winoto, Luis, Wong, Christopher, and Woods, Nikki

Published
2020
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166. HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5–8 days – Implications for HIV Remission

Author

Pinkevych, Mykola, Kent, Stephen J., Tolstrup, Martin, Lewin, Sharon R., Cooper, David A., Søgaard, Ole S., Rasmussen, Thomas A., Kelleher, Anthony D., Cromer, Deborah, and Davenport, Miles P.

Subjects
RNA viruses, Physiology, Immune Cells, Immunology, Drug Resistance, Pathology and Laboratory Medicine, Research and Analysis Methods, Microbiology, Formal Comment, White Blood Cells, Immunodeficiency Viruses, Drug Therapy, Animal Cells, Microbial Control, Virology, Retroviruses, Medicine and Health Sciences, Microbial Pathogens, Pharmacology, Blood Cells, Pharmaceutics, T Cells, Simulation and Modeling, Lentivirus, Organisms, Biology and Life Sciences, HIV, Genetic Variation, Cell Biology, Hematology, Viral Load, Viral Persistence and Latency, Body Fluids, Virus Latency, Blood, Medical Microbiology, Viral Pathogens, Viruses, HIV-1, Antimicrobial Resistance, Pathogens, Cellular Types, Anatomy, Viral Transmission and Infection
Published
2016

167. The impact of transient combination antiretroviral treatment in early HIV infection on viral suppression and immunologic response in later treatment

Author

Pantazis, Nikos Touloumi, Giota Meyer, Laurence Olson, Ashley Costagliola, Dominique Kelleher, Anthony D. Lutsar, Irja Chaix, Marie-Laure Fisher, Martin Moreno, Santiago and Porter, Kholoud Cascade Collaboration EuroCoord

Abstract

Objective:Effects of transient combination antiretroviral treatment (cART) initiated during early HIV infection (EHI) remain unclear. We investigate whether this intervention affects viral suppression and CD4(+) cell count increase following its reinitiation in chronic infection (CHI).Design:Longitudinal observational study.Methods:We identified adult patients from Concerted Action of Seroconversion to AIDS and Death in Europe who seroconverted after 1/1/2000, had a 12 months or less HIV test interval and initiated cART from naive. We classified individuals as pretreated in EHI' if treated within 6 months of seroconversion, interrupted for at least 12 weeks, and reinitiated during CHI. Statistical analysis was performed using survival analysis methods and mixed models.Results:Pretreated and initiated in CHI groups comprised 202 and 4263 individuals, with median follow-up after CHI treatment 4.5 and 3 years, respectively. Both groups had similar virologic response and relapse rates (P=0.585 and P=0.206) but pretreated individuals restarted treatment with higher baseline CD4(+) cell count (approximate to 80cells/l; P

Published
2016

168. Circulating gluten-specific FOXP3 + CD39 + regulatory T cells have impaired suppressive function in patients with celiac disease

Author

Cook, Laura, primary, Munier, C. Mee Ling, additional, Seddiki, Nabila, additional, van Bockel, David, additional, Ontiveros, Noé, additional, Hardy, Melinda Y., additional, Gillies, Jana K., additional, Levings, Megan K., additional, Reid, Hugh H., additional, Petersen, Jan, additional, Rossjohn, Jamie, additional, Anderson, Robert P., additional, Zaunders, John J., additional, Tye-Din, Jason A., additional, and Kelleher, Anthony D., additional

Published
2017
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170. Mechanism of Interferon-Stimulated Gene Induction in HIV-1-Infected Macrophages

Author

Nasr, Najla, primary, Alshehri, Abdullateef A., additional, Wright, Thomas K., additional, Shahid, Maryam, additional, Heiner, Bonnie M., additional, Harman, Andrew N., additional, Botting, Rachel A., additional, Helbig, Karla J., additional, Beard, Michael R., additional, Suzuki, Kazuo, additional, Kelleher, Anthony D., additional, Hertzog, Paul, additional, and Cunningham, Anthony L., additional

Published
2017
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172. Quantification of Residual Germinal Center Activity and HIV-1 DNA and RNA Levels Using Fine Needle Biopsies of Lymph Nodes During Antiretroviral Therapy

Author

Hey-Nguyen, William J., primary, Xu, Yin, additional, Pearson, Chester F., additional, Bailey, Michelle, additional, Suzuki, Kazuo, additional, Tantau, Robyn, additional, Obeid, Solange, additional, Milner, Brad, additional, Field, Andrew, additional, Carr, Andrew, additional, Bloch, Mark, additional, Cooper, David A., additional, Kelleher, Anthony D., additional, Zaunders, John J., additional, and Koelsch, Kersten K., additional

Published
2017
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177. HIV-1 and SIV Predominantly Use CCR5 Expressed on a Precursor Population to Establish Infection in T Follicular Helper Cells

Author

Xu, Yin, primary, Phetsouphanh, Chansavath, additional, Suzuki, Kazuo, additional, Aggrawal, Anu, additional, Graff-Dubois, Stephanie, additional, Roche, Michael, additional, Bailey, Michelle, additional, Alcantara, Sheilajen, additional, Cashin, Kieran, additional, Sivasubramaniam, Rahuram, additional, Koelsch, Kersten K., additional, Autran, Brigitte, additional, Harvey, Richard, additional, Gorry, Paul R., additional, Moris, Arnaud, additional, Cooper, David A., additional, Turville, Stuart, additional, Kent, Stephen J., additional, Kelleher, Anthony D., additional, and Zaunders, John, additional

Published
2017
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182. Immunological biomarkers predict HIV-1 viral rebound after treatment interruption

Author

Hurst, Jacob, Hoffmann, Matthias, Pace, Matthew, Williams, James P., Thornhill, John, Hamlyn, Elizabeth, Meyerowitz, Jodi, Willberg, Chris, Koelsch, Kersten K., Robinson, Nicola, Brown, Helen, Fisher, Martin, Kinloch, Sabine, Cooper, David A., Schechter, Mauro, Tambussi, Giuseppe, Fidler, Sarah, Babiker, Abdel, Weber, Jonathan, Kelleher, Anthony D., Phillips, Rodney E., Frater, John, Wellcome Trust, and Medical Research Council (MRC)

Subjects
HLA CLASS-I, EXPRESSION, Science & Technology, Anti-HIV Agents, MORTALITY, DISEASE PROGRESSION, HIV Infections, DETERMINANTS, Viral Load, Article, INFECTED INDIVIDUALS, CD4 Lymphocyte Count, Multidisciplinary Sciences, ANTIRETROVIRAL THERAPY, Withholding Treatment, T-CELLS, HIV-1, Science & Technology - Other Topics, Humans, POPULATION, Biomarkers, RESPONSES
Abstract

Treatment of HIV-1 infection with antiretroviral therapy (ART) in the weeks following transmission may induce a state of ‘post-treatment control' (PTC) in some patients, in whom viraemia remains undetectable when ART is stopped. Explaining PTC could help our understanding of the processes that maintain viral persistence. Here we show that immunological biomarkers can predict time to viral rebound after stopping ART by analysing data from a randomized study of primary HIV-1 infection incorporating a treatment interruption (TI) after 48 weeks of ART (the SPARTAC trial). T-cell exhaustion markers PD-1, Tim-3 and Lag-3 measured prior to ART strongly predict time to the return of viraemia. These data indicate that T-cell exhaustion markers may identify those latently infected cells with a higher proclivity to viral transcription. Our results may open new avenues for understanding the mechanisms underlying PTC, and eventually HIV-1 eradication., In some HIV-1-infected individuals, viraemia remains undetectable after antiretroviral treatment, but which of these patients will experience viral rebound is difficult to predict. Here the authors show that T cell exhaustion markers before treatment are predictive of shorter time to viral rebound.

Published
2015

183. Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study

Author

Pantazis, Nikos, Porter, Kholoud, Costagliola, Dominique, De Luca, Andrea, Ghosn, Jade, Guiguet, Marguerite, Johnson, Anne M, Kelleher, Anthony D, Morrison, Charles, Thiebaut, Rodolphe, Wittkop, Linda, and Touloumi, Giota

Abstract

Measures of CD4 T-cell count and HIV-1 plasma viral load before antiretroviral therapy are proxies for virulence. Whether these proxies are changing over time has implications for prevention and treatment. The aim of this study was to investigate those trends.

Published
2024
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184. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of [CD8.sup.+] and [CD4.sup.+] T lymphocytes

Author

Oxenius, Annette, Price, David A., Easterbrook, Philippa J., O'Callaghan, Christopher A., Kelleher, Anthony D., Whelan, Joseph A., Sontag, Glenn, Sewell, Andrew K., and Phillips, Rodney E.

Subjects
Biochemistry -- Research, Antiviral agents -- Research, HIV infection -- Causes of, Immunodeficiency -- Analysis, T cells -- Research, Science and technology
Abstract

Highly active antiretroviral therapy (HAART) has been advocated for the management of primary HIV-1 infection without dear understanding of its immunological effects. Here, we demonstrate that early use of HAART during primary infection preserves HIV-specific [CD8.sup.+] T cells physically and functionally while HIV-specific T cell help is sustained. We also show that even transient administration of HAART at seroconversion can preserve HIV-specific immunity. In contrast, delayed initiation of HAART is associated with a progressive loss of HIV-specific [CD8.sup.+] T cells and absent HIV-specific T cell help. These results imply that HIV-specific T help is damaged during primary HIV-1 infection. Early drug treatment, which preserves this immunity, also preserves HIV-specific [CD8.sup.+] T cells. These results have implications for understanding the early pathogenesis of HIV-1 infection and suggest that acute HIV infection should be treated aggressively and as early as possible.

Published
2000

185. Temporal trends in prognostic markers of HIV-1 virulence and transmissibility: an observational cohort study

Author

Pantazis, Nikos Porter, Kholoud Costagliola, Dominique De Luca, Andrea Ghosn, Jade Guiguet, Marguerite Johnson, Anne M. Kelleher, Anthony D. Morrison, Charles Thiebaut, Rodolphe and Wittkop, Linda Touloumi, Giota CASCADE Collaboration EuroCoord

Abstract

Background Measures of CD4 T-cell count and HIV-1 plasma viral load before antiretroviral therapy are proxies for virulence. Whether these proxies are changing over time has implications for prevention and treatment. The aim of this study was to investigate those trends. Methods Data were derived from the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) collaboration of mainly European seroconverter cohorts. Longitudinal CD4 cell counts and plasma viral load measurements before the initiation of antiretroviral therapy or AIDS onset were analysed by use of linear or fractional polynomials mixed models adjusting for all available potential confounders. Calendar time effects were modelled through natural cubic splines. Findings 15 875 individuals seroconverting from 1979 to 2008 fulfilled the inclusion criteria; 3215 (20.3%) were women; median follow-up was 31 months (IQR 14-62); dropout before starting antiretroviral therapy or AIDS onset was 8.1%. Estimated CD4 counts at seroconversion for a typical individual declined from about 770 cells per mu L (95% CI 750-800) in the early 1980s to a plateau of about 570 cells per mu L (555-585) after 2002. CD4 cell rate of loss increased up to 2002. Estimated set-point plasma viral loads increased from 4 . 05 log 10 copies per mL (95% CI 3.98-4.12) in 1980 to 4.50 log 10 copies per mL (4.45-4.54) in 2002 with a tendency of returning to lower loads thereafter. Results were similar when we restricted analyses to various subsets, including adjusting for plasma viral load assay, censored follow-up at 3 years, or used variations of the main statistical approach. Interpretation Our results provide strong indications of increased HIV-1 virulence and transmissibility during the course of the epidemic and a potential plateau effect after about 2002.

Published
2014

186. CD4+ T Follicular Helper and IgA+ B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals

Author

Zaunders, John, primary, Danta, Mark, additional, Bailey, Michelle, additional, Mak, Gerald, additional, Marks, Katherine, additional, Seddiki, Nabila, additional, Xu, Yin, additional, Templeton, David J., additional, Cooper, David A., additional, Boyd, Mark A., additional, Kelleher, Anthony D., additional, and Koelsch, Kersten K., additional

Published
2016
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189. Correction: HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days—Implications for HIV Remission

Author

Pinkevych, Mykola, primary, Cromer, Deborah, additional, Tolstrup, Martin, additional, Grimm, Andrew J., additional, Cooper, David A., additional, Lewin, Sharon R., additional, Søgaard, Ole S., additional, Rasmussen, Thomas A., additional, Kent, Stephen J., additional, Kelleher, Anthony D., additional, and Davenport, Miles P., additional

Published
2016
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192. Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells via p65 and H2B phosphorylation

Author

Li, Jasmine, primary, Hardy, Kristine, additional, Phetsouphanh, Chan, additional, Tu, Wen Juan, additional, Sutcliffe, Elissa L., additional, McCuaig, Robert, additional, Sutton, Christopher R., additional, Zafar, Anjum, additional, Munier, C. Mee Ling, additional, Zaunders, John J., additional, Xu, Yin, additional, Theodoratos, Angelo, additional, Tan, Abel, additional, Lim, Pek Siew, additional, Knaute, Tobias, additional, Masch, Antonia, additional, Zerweck, Johannes, additional, Brezar, Vedran, additional, Milburn, Peter J., additional, Dunn, Jenny, additional, Turner, Stephen J., additional, Seddiki, Nabila, additional, Kelleher, Anthony D., additional, and Rao, Sudha, additional

Published
2016
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193. Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Author

Murray, Daniel D., Suzuki, Kazuo, Law, Matthew, Trebicka, Jonel, Neuhaus, Jacquie, Wentworth, Deborah, Johnson, Margaret, Vjecha, Michael J., Kelleher, Anthony D., Emery, Sean, Lundgren, J., Angus, B., Larson, G., Beral, V., Chaisson, R, Fleming, T., Hill, C., Rogers, Gary, SMART STUDY GROUP, ESPIRIT STUDY GROUP, Murray, Daniel D., Suzuki, Kazuo, Law, Matthew, Trebicka, Jonel, Neuhaus, Jacquie, Wentworth, Deborah, Johnson, Margaret, Vjecha, Michael J., Kelleher, Anthony D., Emery, Sean, Lundgren, J., Angus, B., Larson, G., Beral, V., Chaisson, R, Fleming, T., Hill, C., Rogers, Gary, SMART STUDY GROUP, and ESPIRIT STUDY GROUP

Published
2015

194. Functional cure of HIV: the scale of the challenge

Author

Davenport, Miles P., Khoury, David S., Cromer, Deborah, Lewin, Sharon R., Kelleher, Anthony D., and Kent, Stephen J.

Abstract

A variety of interventions to induce a functional cure of HIV are being explored, with the aim being to allow patients to cease antiretroviral therapy (ART) for prolonged periods of time or for life. These interventions share the goal of inducing ART-free remission from HIV pathogenesis and disease progression but achieve this in quite different ways, by reducing the size of the latent reservoir (for example, small-molecule stimulation of latently infected cells), reducing the number of target cells available for the virus (for example, gene therapy) or improving immune responses (for example, active or passive immunotherapy). Here, we consider a number of these alternative strategies for inducing post-treatment control of HIV and use mathematical modelling to predict the scale of the challenge inherent in these different approaches. For many approaches, over 99.9% efficacy will likely be required to induce durable ART-free remissions. The efficacy of individual approaches is currently far below what we predict will be necessary, and new technologies to achieve lifelong functional cure are needed.

Published
2019
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196. HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation

Author

Colineau, Lucie, primary, Rouers, Angeline, additional, Yamamoto, Takuya, additional, Xu, Yin, additional, Urrutia, Alejandra, additional, Pham, Hang-Phuong, additional, Cardinaud, Sylvain, additional, Samri, Assia, additional, Dorgham, Karim, additional, Coulon, Pierre-Grégoire, additional, Cheynier, Rémi, additional, Hosmalin, Anne, additional, Oksenhendler, Eric, additional, Six, Adrien, additional, Kelleher, Anthony D., additional, Zaunders, John, additional, Koup, Richard A., additional, Autran, Brigitte, additional, Moris, Arnaud, additional, and Graff-Dubois, Stéphanie, additional

Published
2015
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197. Immunological biomarkers predict HIV-1 viral rebound after treatment interruption

Author

Hurst, Jacob, primary, Hoffmann, Matthias, additional, Pace, Matthew, additional, Williams, James P., additional, Thornhill, John, additional, Hamlyn, Elizabeth, additional, Meyerowitz, Jodi, additional, Willberg, Chris, additional, Koelsch, Kersten K., additional, Robinson, Nicola, additional, Brown, Helen, additional, Fisher, Martin, additional, Kinloch, Sabine, additional, Cooper, David A., additional, Schechter, Mauro, additional, Tambussi, Giuseppe, additional, Fidler, Sarah, additional, Babiker, Abdel, additional, Weber, Jonathan, additional, Kelleher, Anthony D., additional, Phillips, Rodney E., additional, and Frater, John, additional

Published
2015
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200. HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days—Implications for HIV Remission

Author

Pinkevych, Mykola, primary, Cromer, Deborah, additional, Tolstrup, Martin, additional, Grimm, Andrew J., additional, Cooper, David A., additional, Lewin, Sharon R., additional, Søgaard, Ole S., additional, Rasmussen, Thomas A., additional, Kent, Stephen J., additional, Kelleher, Anthony D., additional, and Davenport, Miles P., additional

Published
2015
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