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151. LGG-16. PREDICTORS OF OUTCOME IN BRAF-V600E PEDIATRIC GLIOMAS TREATED WITH BRAF INHIBITORS: A REPORT FROM THE PLGG TASKFORCE

Author

Nobre, Liana, primary, Zapotocky, Michal, additional, Ryall, Scott, additional, Stucklin, Ana Guerreiro, additional, Bennett, Julie, additional, Baroni, Lorena, additional, Sumerauer, David, additional, Zamecnik, Josef, additional, Krskova, Lenka, additional, Misove, Adela, additional, Pavelka, Zdenek, additional, Sterba, Jaroslav, additional, Cruz, Ofelia, additional, La Madrid, Andres Morales, additional, Solano, Palma, additional, Quiroga-Cantero, Eduardo, additional, Canete, Adela, additional, Guill, Julia Balaguer, additional, Garre, Maria Luisa, additional, Mascelli, Samatha, additional, Iurilli, Valentina, additional, Hauser, Peter, additional, Frappaz, Didier, additional, Conter, Cecile Faure, additional, Hansford, Jordan, additional, Amayiri, Nisreen, additional, Morse, Helena, additional, Sabel, Magnus, additional, Bechensteen, Anne Grete, additional, Su, Jack, additional, Chintagumpala, Murali, additional, Karajannis, Matthias, additional, Kaur, Gurcharanjeet, additional, Finlay, Jonathan, additional, Osorio, Diana, additional, Coven, Scott, additional, Eisenstat, David, additional, Wilson, Bev, additional, Landeghem, Frank Van, additional, Toledano, Helen, additional, Dahiya, Sonika, additional, Gauvain, Karen, additional, Leary, Sarah, additional, Nicolaides, Theodore, additional, Finch, Elisabeth, additional, Mueller, Sabine, additional, Levy, Jean Mulcahy, additional, Foreman, Nicholas, additional, Ellison, David, additional, Lassaletta, Alvaro, additional, Larouche, Valerie, additional, Mushtaq, Naureen, additional, Milde, Till, additional, Vantilburg, Cornelis, additional, Witt, Olaf, additional, Salgado, Duarte, additional, Harting, Inga, additional, Bornhorst, Miriam, additional, Packer, Roger, additional, Fernandes, Mariana, additional, Injac, Sarah, additional, Bavle, Abhi, additional, Alderete, Daniel, additional, Ramaswamy, Vijay, additional, Taylor, Michael, additional, Dirks, Peter, additional, McKeown, Tara, additional, Bartels, Ute, additional, Bouffet, Eric, additional, Hawkins, Cynthia, additional, and Tabori, Uri, additional

Published
2019
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152. THER-07. A PHASE 0 PHARMACODYNAMIC AND PHARMACOKINETIC STUDY OF EVEROLIMUS IN VESTIBULAR SCHWANNOMA (VS) AND MENINGIOMA PATIENTS

Author

Karajannis, Matthias, primary, Wang, Shiyang, additional, Goldberg, Judith, additional, Roland, Thomas, additional, Sen, Chandranath, additional, Placantonakis, Dimitris, additional, Golfinos, John, additional, Allen, Jeffrey, additional, Dunbar, Erin, additional, Plotkin, Scott, additional, Akshintala, Srivandana, additional, Schneider, Robert, additional, Deng, Jingjing, additional, Neubert, Thomas, additional, Giancotti, Filippo, additional, and Blakeley, Jaishri, additional

Published
2019
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154. List of Contributors

Author

Abou-Khalil, Bassel W., Adamczyk, Peter, Ajtai, Bela, Allen, Jeffrey C., Ally, Brandon, Almeida, Andrea A., Amato, Anthony A., Aminoff, Michael J., Anderson, Nicolaas C., Ashizawa, Tetsuo, Attar, Hatim, Avidan, Alon Y., Baehring, Joachim M., Bag, Asim K., Balcer, Laura J., Ballester, Leomar Y., Baloh, Robert W., Barkoudah, Elizabeth, Barker, Roger A., Barmore, Ryan, Bartleson, J.D., Batla, Amit, Beckham, John David, Beglinger, Leigh, Benninger, David H., Berger, Joseph R., Biller, José, Black, David F., Boulis, Nicholas, Bowley, Michael P., Braksick, Sherri A., Bramlett, Helen M., Bromley, Steven M., Bruni, Joseph, Brust, John C.M., Burnette, W. Bryan, Camfield, Carol, Camfield, Peter, Carson, Alan, Cassimatis, Dimitri, Cavaliere, Robert, Chad, David A., Chandran, Vijay, Chelimsky, Gisela, Chelimsky, Thomas, Chitnis, Tanuja, Chokroverty, Sudhansu, Chukwueke, Ugonma N., Cooper, Paul E., Cordeau, Dany, Courtois, Frédérique, Creutzfeldt, Claire J., Dalmau, Josep, Daroff, Robert B., DasGupta, Ranan, Deutsch, Mariel B., Devereaux, Michael W., DiBacco, Melissa, Dietrich, W. Dalton, Dinakar, Pradeep, Dobkin, Bruce H., Doty, Richard L., Duckwiler, Gary R., Emerson, Ronald G., Fabian, Michelle T., Faridar, Alireza, Fearon, Conor, Felker, Marcia V., Fessler, Richard D., Fessler, Richard G., Fitzgerald, Kathryn C., Flores-Sarnat, Laura, Fogel, Brent L., Forester, Brent P., Fugate, Jennifer E., Gallagher, Martin J., Gardner, Sharon L., Garfinkle, Jarred, Garza, Ivan, Melo de Gusmao, Claudio, Gehl, Carissa, Geiger, Christopher D., Geldmacher, David S., Gerard, Carter, Geschwind, Daniel H., Geschwind, Michael D., Gifford, Katherine A., Gibson, K. Michael, Golomb, Meredith R., Goode, Rachel, Graff-Radford, Jonathan, Groover, Olivia, Guptill, Jeffrey T., Hahn, Cecil D., Hall, Christine, Hallett, Mark, Hamati, Aline I., Hart, David, Hellwig, Sabine, Herholz, Karl, Hill, Alan, Hill, Benjamin D., Hochberg, Fred H., Huntoon, Kristin, Huse, Jason T., Islam, Monica P., Iv, Michael, Jehan, Reza, Jankovic, Joseph, Josephson, S. Andrew, Jovin, Tudor G., Kang, Min K., Karajannis, Matthias A., Kase, Carlos S., Katirji, Bashar, Kerber, Kevin A., Kerchner, Geoffrey A., Khanna, Ryan, Khoury, Samia J., Kirshner, Howard S., Klöppel, Stefan, Koshy, Anita A., Krieger, Stephen C., Kumar, Abhay, Kurtzke, John F., Kutcher, Jeffrey S., Kuo, Sheng-Han, Lang, Anthony E., Lavin, Patrick J.M., Lawrence, Alice, Lazzaro, Marc A., Langner, Sönke, Liebeskind, David S., Lin, Chih-Chun, Lindzen, Eric, Lockwood, Alan H., Lopate, Glenn, Lublin, Fred D., Lyerly, Michael J., Macdonald, Robert L., Mackay, Devin D., Mallery, Robert, Masdeu, Joseph C., Mazziotta, John C., Mendez, Mario F., Meyer, Philipp T., Michaud, Dominique S., Miller, Amanda, Misulis, Karl E., Mitsumoto, Hiroshi, Murray, Brian, Murray, E. Lee, Murray, Evan D., Nahab, Fadi, Nass, Ruth, Nayak, Lakshmi, Newman, Nancy J., Nguyen, Thanh N., Nogueira, Raul G., Nutt, John G., Nuwer, Marc R., O’Banion, D. David, Okun, Michael S., O’Rourke, Justin J.F., Padilla, Claudia R., Panicker, Jalesh N., Parand, Leila, Paulsen, Jane S., Pearl, Phillip L., Peng-Chen, Zhongxing, Perez, David L., Petersen, Ronald C., Pfeiffer, Ronald F., Pitceathly, Robert D.S., Pomeroy, Scott L., Prasad, Sashank, Price, Bruce H., Price, Raymond S., Ptáček, Louis J., Rabinstein, Alejandro A., Ramaswamy, Vijay, Reimschisel, Tyler, Remler, Bernd F., Rijntjes, Michel, Roach, E. Steve, Robertson, Carrie E., Robinson, Maisha T., Ronthal, Michael, Roos, Karen L., Roque, Ashley M., Rosenberg, Gary A., Rosenfeld, Myrna R., Rucker, Janet C., Ruland, Sean D., Safarpour, Delaram, Sanders, Donald B., Sarnat, Harvey B., Saver, Jeffrey L., Sawlani, Komal T., Schapira, Anthony H.V., Schiff, David, Schneck, Michael J., Scott, Kirsten M., Seay, Meagan D., Shaner, D. Malcolm, Sharzehi, Kaveh, Shoamanesh, Ashkan, Sidhu, Reet, Smith, Jonathan H., Snyder, Laura A., So, Yuen T., Solbrig, Marylou V., Srivastava, Siddharth, Stippler, Martina, Stone, Jon, Swanson, Jerry W., Szeder, Viktor, Tan, Lee A., Tateshima, Satoshi, Tee, Boon Lead, Teipel, Stefan J., Thomas, Reena P., Thompson, Philip D., Thurtell, Matthew J., Tomsak, Robert L., Tsao, Bryan, Turner, Chris, Tyler, Kenneth L., Van Uum, Stan H.M., Verma, Ashok, Wall, Michael, Wallin, Mitchell T., Wang, Leo H., Weissenborn, Karin, Weiller, Cornelius, Whealy, Mark A., Wen, Patrick Y., Wijdicks, Eelco F.M., Wilson, Stephen M., Winkel, Daniel, Yerstein, Oleg Y., and Zaidat, Osama O.

Published
2022
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155. Genetic syndromes predisposing to pediatric brain tumors.

Author

Sait, Sameer Farouk, Walsh, Michael F, and Karajannis, Matthias A

Subjects
BRAIN tumors, SYNDROMES in children, NUCLEOTIDE sequencing, CENTRAL nervous system tumors, CHILD patients, GENETIC testing
Abstract

The application of high-throughput sequencing approaches including paired tumor/normal sampling with therapeutic intent has demonstrated that 8%-19% of pediatric CNS tumor patients harbor a germline alteration in a classical tumor predisposition gene (NF1 , P53). In addition, large-scale germline sequencing studies in unselected cohorts of pediatric neuro-oncology patients have demonstrated novel candidate tumor predisposition genes (ELP1 alterations in sonic hedgehog medulloblastoma). Therefore, the possibility of an underlying tumor predisposition syndrome (TPS) should be considered in all pediatric patients diagnosed with a CNS tumor which carries critical implications including accurate prognostication, selection of optimal therapy, screening, risk reduction, and family planning. The Pediatric Cancer Working Group of the American Association for Cancer Research (AACR) recently published consensus screening recommendations for children with the most common TPS. In this review, we provide an overview of the most relevant as well as recently identified TPS associated with the most frequently encountered pediatric CNS tumors with an emphasis on pathogenesis, genetic testing, clinical features, and treatment implications. [ABSTRACT FROM AUTHOR]

Published
2021
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157. NFM-11: pediatric meningiomas are molecularly distinct from adult counterparts [Abstract]

Author

Kirches, Elmar, Sahm, Felix, Blücher, Christina, Boekhoff, Svenja, Schüller, Ulrich, Schittenhelm, Jens, Snuderl, Matija, Karajannis, Matthias, Perry, Arie, Pietsch, Torsten, Müller, Hermann, Rubin, Joshua, Capper, David, Beck, Katja, Schlesner, Matthias, Kropf, Siegfried, Brastianos, Priscilla, Korshunov, Andrey, Pfister, Stefan, and Mawrin, Christian

Subjects
ddc:610
Published
2018

158. A POETIC Phase II study of continuous oral everolimus in recurrent, radiographically progressive pediatric low‐grade glioma.

Author

Wright, Karen D., Yao, Xiaopan, London, Wendy B., Kao, Pei‐Chi, Gore, Lia, Hunger, Stephen, Geyer, Russ, Cohen, Kenneth J., Allen, Jeffrey C., Katzenstein, Howard M., Smith, Amy, Boklan, Jessica, Nazemi, Kellie, Trippett, Tanya, Karajannis, Matthias, Herzog, Cynthia, Destefano, Joseph, Direnzo, Jennifer, Pietrantonio, Jay, and Greenspan, Lianne

Published
2021
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159. PDTM-38. PEDIATRIC MENINGIOMAS ARE CHARACTERIZED BY DISTINCT METHYLATION PROFILES DIFFERENT FROM ADULT MENINGIOMAS

Author

Mawrin, Christian, primary, Kirches, Elmar, additional, Sahm, Felix, additional, Bluecher, Christina, additional, Boekhoff, Svenja, additional, Schüller, Ulrich, additional, Schittenhelm, Jens, additional, Snuderl, Matija, additional, Karajannis, Matthias, additional, Perry, Arie, additional, Pietsch, Thorsten, additional, Mueller, Hermann, additional, Capper, David, additional, Beck, Katja, additional, Schlesner, Matthias, additional, Kropf, Siegfried, additional, Brastianos, Priscilla, additional, Korshunov, Andrey, additional, and Pfister, Stefan, additional

Published
2018
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160. ACTR-34. INTEGRATED CLINICAL EXPERIENCE WITH ONC201 IN PREVIOUSLY-TREATED H3 K27M-MUTANT GLIOMA PATIENTS

Author

Chi, Andrew, primary, Arrillaga-Romany, Isabel, additional, Gardner, Sharon, additional, Wen, Patrick, additional, Batchelor, Tracy, additional, Hall, Matthew, additional, Odia, Yazmin, additional, Khatua, Soumen, additional, Zaky, Wafik, additional, McGovern, Susan, additional, Harrison, Rebecca, additional, de Groot, John, additional, Sumrall, Ashley, additional, Shonka, Nicole, additional, Khatib, Zaid, additional, Karajannis, Matthias, additional, Mueller, Sabine, additional, Tarapore, Rohinton, additional, Merdinger, Krystal, additional, Schalop, Lee, additional, Allen, Joshua, additional, Oster, Wolfgang, additional, and P Mehta, Minesh, additional

Published
2018
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161. Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma

Author

Stafford, James M., primary, Lee, Chul-Hwan, additional, Voigt, Philipp, additional, Descostes, Nicolas, additional, Saldaña-Meyer, Ricardo, additional, Yu, Jia-Ray, additional, Leroy, Gary, additional, Oksuz, Ozgur, additional, Chapman, Jessica R., additional, Suarez, Fernando, additional, Modrek, Aram S., additional, Bayin, N. Sumru, additional, Placantonakis, Dimitris G., additional, Karajannis, Matthias A., additional, Snuderl, Matija, additional, Ueberheide, Beatrix, additional, and Reinberg, Danny, additional

Published
2018
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162. Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma

Author

Snuderl, Matija, primary, Kannan, Kasthuri, additional, Pfaff, Elke, additional, Wang, Shiyang, additional, Stafford, James M., additional, Serrano, Jonathan, additional, Heguy, Adriana, additional, Ray, Karina, additional, Faustin, Arline, additional, Aminova, Olga, additional, Dolgalev, Igor, additional, Stapleton, Stacie L., additional, Zagzag, David, additional, Chiriboga, Luis, additional, Gardner, Sharon L., additional, Wisoff, Jeffrey H., additional, Golfinos, John G., additional, Capper, David, additional, Hovestadt, Volker, additional, Rosenblum, Marc K., additional, Placantonakis, Dimitris G., additional, LeBoeuf, Sarah E., additional, Papagiannakopoulos, Thales Y., additional, Chavez, Lukas, additional, Ahsan, Sama, additional, Eberhart, Charles G., additional, Pfister, Stefan M., additional, Jones, David T. W., additional, and Karajannis, Matthias A., additional

Published
2018
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163. Abstract 3658: DNA methylation of circulating tumor educated leukocytes predicts IDH1/2 mutation status in adult patients with diffuse gliomas

Author

Kloetgen, Andreas, primary, Serrano, Jonathan, additional, Patel, Seema, additional, Bowman, Christopher, additional, Shen, Guomiao, additional, Zagzag, David, additional, Karajannis, Matthias A., additional, Golfinos, John G., additional, Placantonakis, Dimitris, additional, Tsirigos, Aristotelis, additional, Chi, Andrew S., additional, and Snuderl, Matija, additional

Published
2018
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166. EMBR-02. RECURRENT HOMOZYGOUS DELETION OF DROSHA AND MICRODUPLICATION OF PDE4DIP CONTAINING THE ANCESTRAL DUF1220 DOMAIN IN PINEOBLASTOMA

Author

Snuderl, Matija, primary, Kannan, Kasthuri, additional, Pfaff, Elke, additional, Wang, Shiyang, additional, Stafford, James, additional, Serrano, Jonathan, additional, Heguy, Adriana, additional, Ray, Karina, additional, Faustin, Arline, additional, Aminova, Olga, additional, Dolgalev, Igor, additional, Stapleton, Stacie, additional, Zagzag, David, additional, Chiriboga, Luis, additional, Gardner, Sharon, additional, Wisoff, Jeffrey, additional, Golfinos, John, additional, Capper, David, additional, Hovestadt, Volker, additional, Rosenblum, Marc, additional, Placantonakis, Dimitris, additional, LeBoeuf, Sarah, additional, Papagiannakopoulos, Thales, additional, Chavez, Lukas, additional, Ahsan, Sama, additional, Eberhart, Charles, additional, Pfister, Stefan, additional, Jones, David, additional, and Karajannis, Matthias, additional

Published
2018
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168. NFM-09. PRELIMINARY REPORT OF A MULTICENTER, PHASE 2 STUDY OF BEVACIZUMAB IN CHILDREN AND ADULTS WITH NEUROFIBROMATOSIS 2 AND PROGRESSIVE VESTIBULAR SCHWANNOMAS: AN NF CLINICAL TRIALS CONSORTIUM STUDY

Author

Tonsgard, James, primary, Ullrich, Nicole, additional, Blakeley, Jaishri, additional, Rosser, Tena, additional, Packer, Roger, additional, Korf, Bruce, additional, Fisher, Michael, additional, Cutter, Gary, additional, Plotkin, Scott, additional, Karajannis, Matthias, additional, Allen, Jeffrey, additional, Wade Clapp, D, additional, Thomas, Coretta, additional, and Campian, Jian, additional

Published
2018
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169. NFM-11. PEDIATRIC MENINGIOMAS ARE MOLECULARLY DISTINCT FROM ADULT COUNTERPARTS

Author

Kirches, Elmar, primary, Sahm, Felix, additional, Blücher, Christina, additional, Boekhoff, Svenja, additional, Schüller, Ulrich, additional, Schittenhelm, Jens, additional, Snuderl, Matija, additional, Karajannis, Matthias, additional, Perry, Arie, additional, Pietsch, Torsten, additional, Müller, Hermann, additional, Rubin, Joshua, additional, Capper, David, additional, Beck, Katja, additional, Schlesner, Matthias, additional, Kropf, Siegfried, additional, Brastianos, Priscilla, additional, Korshunov, Andrey, additional, Pfister, Stefan, additional, and Mawrin, Christian, additional

Published
2018
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170. IMMU-08. PHASE I TRIAL (NCT02457845) SAFETY, TOLERABILITY AND PRELIMINARY EFFICACY OF IMMUNOVIROTHERAPY WITH HSV G207 IN CHILDREN WITH PROGRESSIVE MALIGNANT SUPRATENTORIAL BRAIN TUMORS

Author

Friedman, Gregory, primary, Bag, Asim, additional, Madan-Swain, Avi, additional, Li, Rong, additional, Kachurak, Kara, additional, Osorio, Diana, additional, Hukin, Juliette, additional, Martin, Allison, additional, Pastakia, Devang, additional, Karajannis, Matthias, additional, Bernstock, Joshua, additional, Fiveash, John, additional, Reddy, Alyssa, additional, Whitley, Richard, additional, Gillespie, Yancey, additional, Markert, James, additional, and Johnston, James, additional

Published
2018
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172. Preliminary report of a multicenter, phase 2 study of bevacizumab in children and adults with neurofibromatosis 2 and progressive vestibular schwannomas: An NF Clinical Trials Consortium study.

Author

Plotkin, Scott Randall, primary, Tonsgard, James H., additional, Ullrich, Nicole J., additional, Allen, Jeffrey C., additional, Rosser, Tena L., additional, Campian, Jian Li, additional, Clapp, David Wade, additional, Fisher, Michael J., additional, Cutter, Gary R., additional, Korf, Bruce R., additional, Packer, Roger, additional, Thomas, Coretta, additional, Karajannis, Matthias A., additional, and Blakeley, Jaishri O'Neill, additional

Published
2018
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173. Multicenter, phase 2 study of bevacizumab in children and adults with neurofibromatosis 2 and progressive vestibular schwannomas: an NF Clinical Trials Consortium study (S23.004)

Author

Plotkin, Scott, primary, Tonsgard, James, additional, Ullrich, Nicole, additional, Allen, Jeffrey, additional, Blakeley, Jaishri, additional, Rosser, Tena, additional, Clapp, David, additional, Campion, Jian, additional, Fisher, Michael, additional, Cutter, Gary, additional, Korf, Bruce, additional, Packer, Roger, additional, Thomas, Coretta, additional, and Karajannis, Matthias, additional

Published
2018
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175. Prospective feasibility and safety assessment of surgical biopsy for patients with newly diagnosed diffuse intrinsic pontine glioma.

Author

Gupta, Nalin, Gupta, Nalin, Goumnerova, Liliana C, Manley, Peter, Chi, Susan N, Neuberg, Donna, Puligandla, Maneka, Fangusaro, Jason, Goldman, Stewart, Tomita, Tadanori, Alden, Tord, DiPatri, Arthur, Rubin, Joshua B, Gauvain, Karen, Limbrick, David, Leonard, Jeffrey, Geyer, J Russel, Leary, Sarah, Browd, Samuel, Wang, Zhihong, Sood, Sandeep, Bendel, Anne, Nagib, Mahmoud, Gardner, Sharon, Karajannis, Matthias A, Harter, David, Ayyanar, Kanyalakshmi, Gump, William, Bowers, Daniel C, Weprin, Bradley, MacDonald, Tobey J, Aguilera, Dolly, Brahma, Barunashish, Robison, Nathan J, Kiehna, Erin, Krieger, Mark, Sandler, Eric, Aldana, Philipp, Khatib, Ziad, Ragheb, John, Bhatia, Sanjiv, Mueller, Sabine, Banerjee, Anu, Bredlau, Amy-Lee, Gururangan, Sri, Fuchs, Herbert, Cohen, Kenneth J, Jallo, George, Dorris, Kathleen, Handler, Michael, Comito, Melanie, Dias, Mark, Nazemi, Kellie, Baird, Lissa, Murray, Jeff, Lindeman, Neal, Hornick, Jason L, Malkin, Hayley, Sinai, Claire, Greenspan, Lianne, Wright, Karen D, Prados, Michael, Bandopadhayay, Pratiti, Ligon, Keith L, Kieran, Mark W, Gupta, Nalin, Gupta, Nalin, Goumnerova, Liliana C, Manley, Peter, Chi, Susan N, Neuberg, Donna, Puligandla, Maneka, Fangusaro, Jason, Goldman, Stewart, Tomita, Tadanori, Alden, Tord, DiPatri, Arthur, Rubin, Joshua B, Gauvain, Karen, Limbrick, David, Leonard, Jeffrey, Geyer, J Russel, Leary, Sarah, Browd, Samuel, Wang, Zhihong, Sood, Sandeep, Bendel, Anne, Nagib, Mahmoud, Gardner, Sharon, Karajannis, Matthias A, Harter, David, Ayyanar, Kanyalakshmi, Gump, William, Bowers, Daniel C, Weprin, Bradley, MacDonald, Tobey J, Aguilera, Dolly, Brahma, Barunashish, Robison, Nathan J, Kiehna, Erin, Krieger, Mark, Sandler, Eric, Aldana, Philipp, Khatib, Ziad, Ragheb, John, Bhatia, Sanjiv, Mueller, Sabine, Banerjee, Anu, Bredlau, Amy-Lee, Gururangan, Sri, Fuchs, Herbert, Cohen, Kenneth J, Jallo, George, Dorris, Kathleen, Handler, Michael, Comito, Melanie, Dias, Mark, Nazemi, Kellie, Baird, Lissa, Murray, Jeff, Lindeman, Neal, Hornick, Jason L, Malkin, Hayley, Sinai, Claire, Greenspan, Lianne, Wright, Karen D, Prados, Michael, Bandopadhayay, Pratiti, Ligon, Keith L, and Kieran, Mark W

Abstract

Background:Diagnosis of diffuse intrinsic pontine glioma (DIPG) has relied on imaging studies, since the appearance is pathognomonic, and surgical risk was felt to be high and unlikely to affect therapy. The DIPG Biology and Treatment Study (DIPG-BATS) reported here incorporated a surgical biopsy at presentation and stratified subjects to receive FDA-approved agents chosen on the basis of specific biologic targets. Methods:Subjects were eligible for the trial if the clinical features and imaging appearance of a newly diagnosed tumor were consistent with a DIPG. Surgical biopsies were performed after enrollment and prior to definitive treatment. All subjects were treated with conventional external beam radiotherapy with bevacizumab, and then stratified to receive bevacizumab with erlotinib or temozolomide, both agents, or neither agent, based on O6-methylguanine-DNA methyltransferase status and epidermal growth factor receptor expression. Whole-genome sequencing and RNA sequencing were performed but not used for treatment assignment. Results:Fifty-three patients were enrolled at 23 institutions, and 50 underwent biopsy. The median age was 6.4 years, with 24 male and 29 female subjects. Surgical biopsies were performed with a specified technique and no deaths were attributed to the procedure. Two subjects experienced grade 3 toxicities during the procedure (apnea, n = 1; hypertension, n = 1). One subject experienced a neurologic deficit (left hemiparesis) that did not fully recover. Of the 50 tumors biopsied, 46 provided sufficient tissue to perform the study assays (92%, two-stage exact binomial 90% CI: 83%-97%). Conclusions:Surgical biopsy of DIPGs is technically feasible, associated with acceptable risks, and can provide biologic data that can inform treatment decisions.

Published
2018

176. DNA methylation-based classification of central nervous system tumours

Author

Capper, David, Jones, David T.W., Sill, Martin, Hovestadt, Volker, Schrimpf, Daniel, Sturm, Dominik, Koelsche, Christian, Sahm, Felix, Chavez, Lukas, Reuss, David E., Kratz, Annekathrin, Wefers, Annika K., Huang, Kristin, Pajtler, Kristian W., Schweizer, Leonille, Stichel, Damian, Olar, Adriana, Engel, Nils W., Lindenberg, Kerstin, Harter, Patrick N., Braczynski, Anne K., Plate, Karl H., Dohmen, Hildegard, Garvalov, Boyan K., Coras, Roland, Hölsken, Annett, Hewer, Ekkehard, Bewerunge-Hudler, Melanie, Schick, Matthias, Fischer, Roger, Beschorner, Rudi, Schittenhelm, Jens, Staszewski, Ori, Wani, Khalida, Varlet, Pascale, Pages, Melanie, Temming, Petra, Lohmann, Dietmar, Selt, Florian, Witt, Hendrik, Milde, Till, Witt, Olaf, Aronica, Eleonora, Giangaspero, Felice, Rushing, Elisabeth, Scheurlen, Wolfram, Geisenberger, Christoph, Rodriguez, Fausto J., Becker, Albert, Preusser, Matthias, Haberler, Christine, Bjerkvig, Rolf, Cryan, Jane, Farrell, Michael, Deckert, Martina, Hench, Jürgen, Frank, Stephan, Serrano, Jonathan, Kannan, Kasthuri, Tsirigos, Aristotelis, Brück, Wolfgang, Hofer, Silvia, Brehmer, Stefanie, Seiz-Rosenhagen, Marcel, Hänggi, Daniel, Hans, Volkmar, Rozsnoki, Stephanie, Hansford, Jordan R., Kohlhof, Patricia, Kristensen, Bjarne W., Lechner, Matt, Lopes, Beatriz, Mawrin, Christian, Ketter, Ralf, Kulozik, Andreas, Khatib, Ziad, Heppner, Frank, Koch, Arend, Jouvet, Anne, Keohane, Catherine, Mühleisen, Helmut, Mueller, Wolf, Pohl, Ute, Prinz, Marco, Benner, Axel, Zapatka, Marc, Gottardo, Nicholas G., Driever, Pablo Hernáiz, Kramm, Christof M., Müller, Hermann L., Rutkowski, Stefan, Von Hoff, Katja, Frühwald, Michael C., Gnekow, Astrid, Fleischhack, Gudrun, Tippelt, Stephan, Calaminus, Gabriele, Monoranu, Camelia Maria, Perry, Arie, Jones, Chris, Jacques, Thomas S., Radlwimmer, Bernhard, Gessi, Marco, Pietsch, Torsten, Schramm, Johannes, Schackert, Gabriele, Westphal, Manfred, Reifenberger, Guido, Wesseling, Pieter, Weller, Michael, Collins, Vincent Peter, Blümcke, Ingmar, Bendszus, Martin, Debus, Jürgen, Huang, Annie, Jabado, Nada, Northcott, Paul A., Paulus, Werner, Gajjar, Amar, Robinson, Giles W., Taylor, Michael D., Jaunmuktane, Zane, Ryzhova, Marina, Platten, Michael, Unterberg, Andreas, Wick, Wolfgang, Karajannis, Matthias A., Mittelbronn, Michel, Acker, Till, Hartmann, Christian, Aldape, Kenneth, Schüller, Ulrich, Buslei, Rolf, Lichter, Peter, Kool, Marcel, Herold-Mende, Christel, Ellison, David W., Hasselblatt, Martin, Snuderl, Matija, Brandner, Sebastian, Korshunov, Andrey, Von Deimling, Andreas, Pfister, Stefan M., Capper, David, Jones, David T.W., Sill, Martin, Hovestadt, Volker, Schrimpf, Daniel, Sturm, Dominik, Koelsche, Christian, Sahm, Felix, Chavez, Lukas, Reuss, David E., Kratz, Annekathrin, Wefers, Annika K., Huang, Kristin, Pajtler, Kristian W., Schweizer, Leonille, Stichel, Damian, Olar, Adriana, Engel, Nils W., Lindenberg, Kerstin, Harter, Patrick N., Braczynski, Anne K., Plate, Karl H., Dohmen, Hildegard, Garvalov, Boyan K., Coras, Roland, Hölsken, Annett, Hewer, Ekkehard, Bewerunge-Hudler, Melanie, Schick, Matthias, Fischer, Roger, Beschorner, Rudi, Schittenhelm, Jens, Staszewski, Ori, Wani, Khalida, Varlet, Pascale, Pages, Melanie, Temming, Petra, Lohmann, Dietmar, Selt, Florian, Witt, Hendrik, Milde, Till, Witt, Olaf, Aronica, Eleonora, Giangaspero, Felice, Rushing, Elisabeth, Scheurlen, Wolfram, Geisenberger, Christoph, Rodriguez, Fausto J., Becker, Albert, Preusser, Matthias, Haberler, Christine, Bjerkvig, Rolf, Cryan, Jane, Farrell, Michael, Deckert, Martina, Hench, Jürgen, Frank, Stephan, Serrano, Jonathan, Kannan, Kasthuri, Tsirigos, Aristotelis, Brück, Wolfgang, Hofer, Silvia, Brehmer, Stefanie, Seiz-Rosenhagen, Marcel, Hänggi, Daniel, Hans, Volkmar, Rozsnoki, Stephanie, Hansford, Jordan R., Kohlhof, Patricia, Kristensen, Bjarne W., Lechner, Matt, Lopes, Beatriz, Mawrin, Christian, Ketter, Ralf, Kulozik, Andreas, Khatib, Ziad, Heppner, Frank, Koch, Arend, Jouvet, Anne, Keohane, Catherine, Mühleisen, Helmut, Mueller, Wolf, Pohl, Ute, Prinz, Marco, Benner, Axel, Zapatka, Marc, Gottardo, Nicholas G., Driever, Pablo Hernáiz, Kramm, Christof M., Müller, Hermann L., Rutkowski, Stefan, Von Hoff, Katja, Frühwald, Michael C., Gnekow, Astrid, Fleischhack, Gudrun, Tippelt, Stephan, Calaminus, Gabriele, Monoranu, Camelia Maria, Perry, Arie, Jones, Chris, Jacques, Thomas S., Radlwimmer, Bernhard, Gessi, Marco, Pietsch, Torsten, Schramm, Johannes, Schackert, Gabriele, Westphal, Manfred, Reifenberger, Guido, Wesseling, Pieter, Weller, Michael, Collins, Vincent Peter, Blümcke, Ingmar, Bendszus, Martin, Debus, Jürgen, Huang, Annie, Jabado, Nada, Northcott, Paul A., Paulus, Werner, Gajjar, Amar, Robinson, Giles W., Taylor, Michael D., Jaunmuktane, Zane, Ryzhova, Marina, Platten, Michael, Unterberg, Andreas, Wick, Wolfgang, Karajannis, Matthias A., Mittelbronn, Michel, Acker, Till, Hartmann, Christian, Aldape, Kenneth, Schüller, Ulrich, Buslei, Rolf, Lichter, Peter, Kool, Marcel, Herold-Mende, Christel, Ellison, David W., Hasselblatt, Martin, Snuderl, Matija, Brandner, Sebastian, Korshunov, Andrey, Von Deimling, Andreas, and Pfister, Stefan M.

Published
2018

177. 2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis.

Author

Fisher, Michael J, Fisher, Michael J, Belzberg, Allan J, de Blank, Peter, De Raedt, Thomas, Elefteriou, Florent, Ferner, Rosalie E, Giovannini, Marco, Harris, Gordon J, Kalamarides, Michel, Karajannis, Matthias A, Kim, AeRang, Lázaro, Conxi, Le, Lu Q, Li, Wei, Listernick, Robert, Martin, Staci, Morrison, Helen, Pasmant, Eric, Ratner, Nancy, Schorry, Elisabeth, Ullrich, Nicole J, Viskochil, David, Weiss, Brian, Widemann, Brigitte C, Zhu, Yuan, Bakker, Annette, Serra, Eduard, Fisher, Michael J, Fisher, Michael J, Belzberg, Allan J, de Blank, Peter, De Raedt, Thomas, Elefteriou, Florent, Ferner, Rosalie E, Giovannini, Marco, Harris, Gordon J, Kalamarides, Michel, Karajannis, Matthias A, Kim, AeRang, Lázaro, Conxi, Le, Lu Q, Li, Wei, Listernick, Robert, Martin, Staci, Morrison, Helen, Pasmant, Eric, Ratner, Nancy, Schorry, Elisabeth, Ullrich, Nicole J, Viskochil, David, Weiss, Brian, Widemann, Brigitte C, Zhu, Yuan, Bakker, Annette, and Serra, Eduard

Abstract

Organized and hosted by the Children's Tumor Foundation (CTF), the Neurofibromatosis (NF) conference is the premier annual gathering for clinicians and researchers interested in neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2), and schwannomatosis (SWN). The 2016 edition constituted a blend of clinical and basic aspects of NF research that helped in clarifying different advances in the field. The incorporation of next generation sequencing is changing the way genetic diagnostics is performed for NF and related disorders, providing solutions to problems like genetic heterogeneity, overlapping clinical manifestations, or the presence of mosaicism. The transformation from plexiform neurofibroma (PNF) to malignant peripheral nerve sheath tumor (MPNST) is being clarified, along with new management and treatments for benign and premalignant tumors. Promising new cellular and in vivo models for understanding the musculoskeletal abnormalities in NF1, the development of NF2 or SWN associated schwannomas, and clarifying the cells that give rise to NF1-associated optic pathway glioma were presented. The interaction of neurofibromin and SPRED1 was described comprehensively, providing functional insight that will help in the interpretation of pathogenicity of certain missense variants identified in NF1 and Legius syndrome patients. Novel promising imaging techniques are being developed, as well as new integrative and holistic management models for patients that take into account psychological, social, and biological factors. Importantly, new therapeutic approaches for schwannomas, meningiomas, ependymomas, PNF, and MPNST are being pursued. This report highlights the major advances that were presented at the 2016 CTF NF conference.

Published
2018

178. Heterogeneity within the PF-EPN-B ependymoma subgroup.

Author

Cavalli, Florence MG, Cavalli, Florence MG, Hübner, Jens-Martin, Sharma, Tanvi, Luu, Betty, Sill, Martin, Zapotocky, Michal, Mack, Stephen C, Witt, Hendrik, Lin, Tong, Shih, David JH, Ho, Ben, Santi, Mariarita, Emery, Lyndsey, Hukin, Juliette, Dunham, Christopher, McLendon, Roger E, Lipp, Eric S, Gururangan, Sridharan, Grossbach, Andrew, French, Pim, Kros, Johan M, van Veelen, Marie-Lise C, Rao, Amulya A Nageswara, Giannini, Caterina, Leary, Sarah, Jung, Shin, Faria, Claudia C, Mora, Jaume, Schüller, Ulrich, Alonso, Marta M, Chan, Jennifer A, Klekner, Almos, Chambless, Lola B, Hwang, Eugene I, Massimino, Maura, Eberhart, Charles G, Karajannis, Matthias A, Lu, Benjamin, Liau, Linda M, Zollo, Massimo, Ferrucci, Veronica, Carlotti, Carlos, Tirapelli, Daniela PC, Tabori, Uri, Bouffet, Eric, Ryzhova, Marina, Ellison, David W, Merchant, Thomas E, Gilbert, Mark R, Armstrong, Terri S, Korshunov, Andrey, Pfister, Stefan M, Taylor, Michael D, Aldape, Kenneth, Pajtler, Kristian W, Kool, Marcel, Ramaswamy, Vijay, Cavalli, Florence MG, Cavalli, Florence MG, Hübner, Jens-Martin, Sharma, Tanvi, Luu, Betty, Sill, Martin, Zapotocky, Michal, Mack, Stephen C, Witt, Hendrik, Lin, Tong, Shih, David JH, Ho, Ben, Santi, Mariarita, Emery, Lyndsey, Hukin, Juliette, Dunham, Christopher, McLendon, Roger E, Lipp, Eric S, Gururangan, Sridharan, Grossbach, Andrew, French, Pim, Kros, Johan M, van Veelen, Marie-Lise C, Rao, Amulya A Nageswara, Giannini, Caterina, Leary, Sarah, Jung, Shin, Faria, Claudia C, Mora, Jaume, Schüller, Ulrich, Alonso, Marta M, Chan, Jennifer A, Klekner, Almos, Chambless, Lola B, Hwang, Eugene I, Massimino, Maura, Eberhart, Charles G, Karajannis, Matthias A, Lu, Benjamin, Liau, Linda M, Zollo, Massimo, Ferrucci, Veronica, Carlotti, Carlos, Tirapelli, Daniela PC, Tabori, Uri, Bouffet, Eric, Ryzhova, Marina, Ellison, David W, Merchant, Thomas E, Gilbert, Mark R, Armstrong, Terri S, Korshunov, Andrey, Pfister, Stefan M, Taylor, Michael D, Aldape, Kenneth, Pajtler, Kristian W, Kool, Marcel, and Ramaswamy, Vijay

Abstract

Posterior fossa ependymoma comprise three distinct molecular variants, termed PF-EPN-A (PFA), PF-EPN-B (PFB), and PF-EPN-SE (subependymoma). Clinically, they are very disparate and PFB tumors are currently being considered for a trial of radiation avoidance. However, to move forward, unraveling the heterogeneity within PFB would be highly desirable. To discern the molecular heterogeneity within PFB, we performed an integrated analysis consisting of DNA methylation profiling, copy-number profiling, gene expression profiling, and clinical correlation across a cohort of 212 primary posterior fossa PFB tumors. Unsupervised spectral clustering and t-SNE analysis of genome-wide methylation data revealed five distinct subtypes of PFB tumors, termed PFB1-5, with distinct demographics, copy-number alterations, and gene expression profiles. All PFB subtypes were distinct from PFA and posterior fossa subependymomas. Of the five subtypes, PFB4 and PFB5 are more discrete, consisting of younger and older patients, respectively, with a strong female-gender enrichment in PFB5 (age: p = 0.011, gender: p = 0.04). Broad copy-number aberrations were common; however, many events such as chromosome 2 loss, 5 gain, and 17 loss were enriched in specific subtypes and 1q gain was enriched in PFB1. Late relapses were common across all five subtypes, but deaths were uncommon and present in only two subtypes (PFB1 and PFB3). Unlike the case in PFA ependymoma, 1q gain was not a robust marker of poor progression-free survival; however, chromosome 13q loss may represent a novel marker for risk stratification across the spectrum of PFB subtypes. Similar to PFA ependymoma, there exists a significant intertumoral heterogeneity within PFB, with distinct molecular subtypes identified. Even when accounting for this heterogeneity, extent of resection remains the strongest predictor of poor outcome. However, this biological heterogeneity must be accounted for in future preclinical modeling and personalize

Published
2018

179. DNA methylation-based classification of central nervous system tumours

Author

Pathologie Pathologen staf, Capper, David, Jones, David T.W., Sill, Martin, Hovestadt, Volker, Schrimpf, Daniel, Sturm, Dominik, Koelsche, Christian, Sahm, Felix, Chavez, Lukas, Reuss, David E., Kratz, Annekathrin, Wefers, Annika K., Huang, Kristin, Pajtler, Kristian W., Schweizer, Leonille, Stichel, Damian, Olar, Adriana, Engel, Nils W., Lindenberg, Kerstin, Harter, Patrick N., Braczynski, Anne K., Plate, Karl H., Dohmen, Hildegard, Garvalov, Boyan K., Coras, Roland, Hölsken, Annett, Hewer, Ekkehard, Bewerunge-Hudler, Melanie, Schick, Matthias, Fischer, Roger, Beschorner, Rudi, Schittenhelm, Jens, Staszewski, Ori, Wani, Khalida, Varlet, Pascale, Pages, Melanie, Temming, Petra, Lohmann, Dietmar, Selt, Florian, Witt, Hendrik, Milde, Till, Witt, Olaf, Aronica, Eleonora, Giangaspero, Felice, Rushing, Elisabeth, Scheurlen, Wolfram, Geisenberger, Christoph, Rodriguez, Fausto J., Becker, Albert, Preusser, Matthias, Haberler, Christine, Bjerkvig, Rolf, Cryan, Jane, Farrell, Michael, Deckert, Martina, Hench, Jürgen, Frank, Stephan, Serrano, Jonathan, Kannan, Kasthuri, Tsirigos, Aristotelis, Brück, Wolfgang, Hofer, Silvia, Brehmer, Stefanie, Seiz-Rosenhagen, Marcel, Hänggi, Daniel, Hans, Volkmar, Rozsnoki, Stephanie, Hansford, Jordan R., Kohlhof, Patricia, Kristensen, Bjarne W., Lechner, Matt, Lopes, Beatriz, Mawrin, Christian, Ketter, Ralf, Kulozik, Andreas, Khatib, Ziad, Heppner, Frank, Koch, Arend, Jouvet, Anne, Keohane, Catherine, Mühleisen, Helmut, Mueller, Wolf, Pohl, Ute, Prinz, Marco, Benner, Axel, Zapatka, Marc, Gottardo, Nicholas G., Driever, Pablo Hernáiz, Kramm, Christof M., Müller, Hermann L., Rutkowski, Stefan, Von Hoff, Katja, Frühwald, Michael C., Gnekow, Astrid, Fleischhack, Gudrun, Tippelt, Stephan, Calaminus, Gabriele, Monoranu, Camelia Maria, Perry, Arie, Jones, Chris, Jacques, Thomas S., Radlwimmer, Bernhard, Gessi, Marco, Pietsch, Torsten, Schramm, Johannes, Schackert, Gabriele, Westphal, Manfred, Reifenberger, Guido, Wesseling, Pieter, Weller, Michael, Collins, Vincent Peter, Blümcke, Ingmar, Bendszus, Martin, Debus, Jürgen, Huang, Annie, Jabado, Nada, Northcott, Paul A., Paulus, Werner, Gajjar, Amar, Robinson, Giles W., Taylor, Michael D., Jaunmuktane, Zane, Ryzhova, Marina, Platten, Michael, Unterberg, Andreas, Wick, Wolfgang, Karajannis, Matthias A., Mittelbronn, Michel, Acker, Till, Hartmann, Christian, Aldape, Kenneth, Schüller, Ulrich, Buslei, Rolf, Lichter, Peter, Kool, Marcel, Herold-Mende, Christel, Ellison, David W., Hasselblatt, Martin, Snuderl, Matija, Brandner, Sebastian, Korshunov, Andrey, Von Deimling, Andreas, Pfister, Stefan M., Pathologie Pathologen staf, Capper, David, Jones, David T.W., Sill, Martin, Hovestadt, Volker, Schrimpf, Daniel, Sturm, Dominik, Koelsche, Christian, Sahm, Felix, Chavez, Lukas, Reuss, David E., Kratz, Annekathrin, Wefers, Annika K., Huang, Kristin, Pajtler, Kristian W., Schweizer, Leonille, Stichel, Damian, Olar, Adriana, Engel, Nils W., Lindenberg, Kerstin, Harter, Patrick N., Braczynski, Anne K., Plate, Karl H., Dohmen, Hildegard, Garvalov, Boyan K., Coras, Roland, Hölsken, Annett, Hewer, Ekkehard, Bewerunge-Hudler, Melanie, Schick, Matthias, Fischer, Roger, Beschorner, Rudi, Schittenhelm, Jens, Staszewski, Ori, Wani, Khalida, Varlet, Pascale, Pages, Melanie, Temming, Petra, Lohmann, Dietmar, Selt, Florian, Witt, Hendrik, Milde, Till, Witt, Olaf, Aronica, Eleonora, Giangaspero, Felice, Rushing, Elisabeth, Scheurlen, Wolfram, Geisenberger, Christoph, Rodriguez, Fausto J., Becker, Albert, Preusser, Matthias, Haberler, Christine, Bjerkvig, Rolf, Cryan, Jane, Farrell, Michael, Deckert, Martina, Hench, Jürgen, Frank, Stephan, Serrano, Jonathan, Kannan, Kasthuri, Tsirigos, Aristotelis, Brück, Wolfgang, Hofer, Silvia, Brehmer, Stefanie, Seiz-Rosenhagen, Marcel, Hänggi, Daniel, Hans, Volkmar, Rozsnoki, Stephanie, Hansford, Jordan R., Kohlhof, Patricia, Kristensen, Bjarne W., Lechner, Matt, Lopes, Beatriz, Mawrin, Christian, Ketter, Ralf, Kulozik, Andreas, Khatib, Ziad, Heppner, Frank, Koch, Arend, Jouvet, Anne, Keohane, Catherine, Mühleisen, Helmut, Mueller, Wolf, Pohl, Ute, Prinz, Marco, Benner, Axel, Zapatka, Marc, Gottardo, Nicholas G., Driever, Pablo Hernáiz, Kramm, Christof M., Müller, Hermann L., Rutkowski, Stefan, Von Hoff, Katja, Frühwald, Michael C., Gnekow, Astrid, Fleischhack, Gudrun, Tippelt, Stephan, Calaminus, Gabriele, Monoranu, Camelia Maria, Perry, Arie, Jones, Chris, Jacques, Thomas S., Radlwimmer, Bernhard, Gessi, Marco, Pietsch, Torsten, Schramm, Johannes, Schackert, Gabriele, Westphal, Manfred, Reifenberger, Guido, Wesseling, Pieter, Weller, Michael, Collins, Vincent Peter, Blümcke, Ingmar, Bendszus, Martin, Debus, Jürgen, Huang, Annie, Jabado, Nada, Northcott, Paul A., Paulus, Werner, Gajjar, Amar, Robinson, Giles W., Taylor, Michael D., Jaunmuktane, Zane, Ryzhova, Marina, Platten, Michael, Unterberg, Andreas, Wick, Wolfgang, Karajannis, Matthias A., Mittelbronn, Michel, Acker, Till, Hartmann, Christian, Aldape, Kenneth, Schüller, Ulrich, Buslei, Rolf, Lichter, Peter, Kool, Marcel, Herold-Mende, Christel, Ellison, David W., Hasselblatt, Martin, Snuderl, Matija, Brandner, Sebastian, Korshunov, Andrey, Von Deimling, Andreas, and Pfister, Stefan M.

Published
2018

180. Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation

Author

Legius, Eric, Messiaen, Ludwine, Wolkenstein, Pierre, Pancza, Patrice, Avery, Robert A., Berman, Yemima, Blakeley, Jaishri, Babovic-Vuksanovic, Dusica, Cunha, Karin Soares, Ferner, Rosalie, Fisher, Michael J., Friedman, Jan M., Gutmann, David H., Kehrer-Sawatzki, Hildegard, Korf, Bruce R., Mautner, Victor-Felix, Peltonen, Sirkku, Rauen, Katherine A., Riccardi, Vincent, Schorry, Elizabeth, Stemmer-Rachamimov, Anat, Stevenson, David A., Tadini, Gianluca, Ullrich, Nicole J., Viskochil, David, Wimmer, Katharina, Yohay, Kaleb, Gomes, Alicia, Jordan, Justin T., Mautner, Victor, Merker, Vanessa L., Smith, Miriam J., Stevenson, David, Anten, Monique, Aylsworth, Arthur, Baralle, Diana, Barbarot, Sebastien, Barker, Fred, Ben-Shachar, Shay, Bergner, Amanda, Bessis, Didier, Blanco, Ignacio, Cassiman, Catherine, Ciavarelli, Patricia, Clementi, Maurizio, Frébourg, Thierry, Giovannini, Marco, Halliday, Dorothy, Hammond, Chris, Hanemann, C.O., Hanson, Helen, Heiberg, Arvid, Joly, Pascal, Kalamarides, Michel, Karajannis, Matthias, Kroshinsky, Daniela, Larralde, Margarita, Lázaro, Conxi, Le, Lu, Link, Michael, Listernick, Robert, MacCollin, Mia, Mallucci, Conor, Moertel, Christopher, Mueller, Amy, Ngeow, Joanne, Oostenbrink, Rianne, Packer, Roger, Papi, Laura, Parry, Allyson, Peltonen, Juha, Pichard, Dominique, Poppe, Bruce, Rezende, Nilton, Rodrigues, Luiz Oswaldo, Rosser, Tena, Ruggieri, Martino, Serra, Eduard, Steinke-Lange, Verena, Stivaros, Stavros Michael, Taylor, Amy, Toelen, Jaan, Tonsgard, James, Trevisson, Eva, Upadhyaya, Meena, Varan, Ali, Wilson, Meredith, Wu, Hao, Zadeh, Gelareh, Huson, Susan M., Evans, D. Gareth, and Plotkin, Scott R.

Abstract

By incorporating major developments in genetics, ophthalmology, dermatology, and neuroimaging, to revise the diagnostic criteria for neurofibromatosis type 1 (NF1) and to establish diagnostic criteria for Legius syndrome (LGSS).

Published
2021
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181. Clinical Experience of Cerebrospinal Fluid–Based Liquid Biopsy Demonstrates Superiority of Cell-Free DNA over Cell Pellet Genomic DNA for Molecular Profiling

Author

Bale, Tejus A., Yang, Soo-Ryum, Solomon, James P., Nafa, Khedoudja, Middha, Sumit, Casanova, Jacklyn, Sadowska, Justyna, Skakodub, Anna, Ahmad, Hamza, Yu, Helena A., Riely, Greg J., Kris, Mark G., Chandarlapaty, Sarat, Rosenblum, Marc K., Gavrilovic, Igor, Karajannis, Matthias A., Pentsova, Elena, Miller, Alexandra, Boire, Adrienne, Mellinghoff, Ingo, Berger, Michael F., Zehir, Ahmet, Ladanyi, Marc, Benayed, Ryma, and Arcila, Maria E.

Abstract

Cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) offers unique opportunities for genomic profiling of tumors involving the central nervous system but remains uncommonly used in clinical practice. We describe our clinical experience using cfDNA from CSF for routine molecular testing using Memorial Sloan Kettering Integrated Mutation Profiling of Actionable Cancer Targets (targeting 468 cancer-related genes). In all, 148 cfDNA samples were assessed, comparing results of cfDNA versus genomic DNA (gDNA; gDNA from cell pellets) derived from the same CSF sample and the primary tumor. Of these, 71.6% (106/148) were successfully sequenced. Somatic alterations (mutations and fusions) were observed in 70.8% (75/106) of the samples; 97.3% (73/75) comprised variants confirming central nervous system involvement by a previously diagnosed tumor, 14.7% (11/75) had additional variants consistent with a therapy-related resistance mechanism, and 2.7% (2/75) had variants that independently diagnosed a new primary. Among samples with paired cfDNA and gDNA sequencing results, cfDNA was more frequently positive for at least one mutation [43.6% (55/126) versus 19.8% (25/126)] and harbored 1.6× more mutations (6.94 versus 4.65; P = 0.005), with higher mean variant allele fractions (41.1% versus 13.0%; P < 0.0001). Among mutation-positive cfDNAs, the corresponding gDNA was frequently negative (44.6%; 25/55) or failed sequencing (17.8%; 9/55). Routine molecular profiling of cfDNA is superior to gDNA from CSF, facilitating the capture of mutations at high variant allele frequency, even in the context of a negative cytology.

Published
2021
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182. Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

Author

Ramaswamy, Vijay, Hielscher, Thomas, Mack, Stephen C, Lassaletta, Alvaro, Lin, Tong, Pajtler, Kristian W, Jones, David TW, Luu, Betty, Cavalli, Florence MG, Aldape, Kenneth, Remke, Marc, Mynarek, Martin, Rutkowski, Stefan, Gururangan, Sridharan, McLendon, Roger E, Lipp, Eric S, Dunham, Christopher, Hukin, Juliette, Eisenstat, David D, Fulton, Dorcas, van Landeghem, Frank KH, Santi, Mariarita, van Veelen, Marie-Lise C, Van Meir, Erwin G, Osuka, Satoru, Fan, Xing, Muraszko, Karin M, Tirapelli, Daniela PC, Oba-Shinjo, Sueli M, Marie, Suely KN, Carlotti, Carlos G, Lee, Ji Yeoun, Rao, Amulya A Nageswara, Giannini, Caterina, Faria, Claudia C, Nunes, Sofia, Mora, Jaume, Hamilton, Ronald L, Hauser, Peter, Jabado, Nada, Petrecca, Kevin, Jung, Shin, Massimi, Luca, Zollo, Massimo, Cinalli, Giuseppe, Bognár, László, Klekner, Almos, Hortobágyi, Tibor, Leary, Sarah, Ermoian, Ralph P, Olson, James M, Leonard, Jeffrey R, Gardner, Corrine, Grajkowska, Wieslawa A, Chambless, Lola B, Cain, Jason, Eberhart, Charles G, Ahsan, Sama, Massimino, Maura, Giangaspero, Felice, Buttarelli, Francesca R, Packer, Roger J, Emery, Lyndsey, Yong, William H, Soto, Horacio, Liau, Linda M, Everson, Richard, Grossbach, Andrew, Shalaby, Tarek, Grotzer, Michael, Karajannis, Matthias A, Zagzag, David, Wheeler, Helen, von Hoff, Katja, Alonso, Marta M, Tuñon, Teresa, Schüller, Ulrich, Zitterbart, Karel, Sterba, Jaroslav, Chan, Jennifer A, Guzman, Miguel, Elbabaa, Samer K, Colman, Howard, Dhall, Girish, Fisher, Paul G, Fouladi, Maryam, Gajjar, Amar, Goldman, Stewart, Hwang, Eugene, Kool, Marcel, Ladha, Harshad, Vera-Bolanos, Elizabeth, Wani, Khalida, Lieberman, Frank, Mikkelsen, Tom, Omuro, Antonio M, Pollack, Ian F, Prados, Michael, Robins, H Ian, and Soffietti, Riccardo

Subjects
Adult, Male, Pediatric, Adolescent, Pediatric Cancer, Clinical Sciences, Oncology and Carcinogenesis, Infant, Infratentorial Neoplasms, Cytoreduction Surgical Procedures, Combined Modality Therapy, Cohort Studies, Rare Diseases, Ependymoma, Humans, Female, Patient Safety, Oncology & Carcinogenesis, Child, Preschool, Retrospective Studies, Cancer
Abstract

PurposePosterior fossa ependymoma comprises two distinct molecular variants termed EPN_PFA and EPN_PFB that have a distinct biology and natural history. The therapeutic value of cytoreductive surgery and radiation therapy for posterior fossa ependymoma after accounting for molecular subgroup is not known.MethodsFour independent nonoverlapping retrospective cohorts of posterior fossa ependymomas (n = 820) were profiled using genome-wide methylation arrays. Risk stratification models were designed based on known clinical and newly described molecular biomarkers identified by multivariable Cox proportional hazards analyses.ResultsMolecular subgroup is a powerful independent predictor of outcome even when accounting for age or treatment regimen. Incompletely resected EPN_PFA ependymomas have a dismal prognosis, with a 5-year progression-free survival ranging from 26.1% to 56.8% across all four cohorts. Although first-line (adjuvant) radiation is clearly beneficial for completely resected EPN_PFA, a substantial proportion of patients with EPN_PFB can be cured with surgery alone, and patients with relapsed EPN_PFB can often be treated successfully with delayed external-beam irradiation.ConclusionThe most impactful biomarker for posterior fossa ependymoma is molecular subgroup affiliation, independent of other demographic or treatment variables. However, both EPN_PFA and EPN_PFB still benefit from increased extent of resection, with the survival rates being particularly poor for subtotally resected EPN_PFA, even with adjuvant radiation therapy. Patients with EPN_PFB who undergo gross total resection are at lower risk for relapse and should be considered for inclusion in a randomized clinical trial of observation alone with radiation reserved for those who experience recurrence.

Published
2016

184. Abstract PR01: A DNA methylation-based classifier for accurate molecular diagnosis of bone sarcomas

Author

Wu, Shengyang, primary, Cooper, Benjamin, additional, Bu, Fang, additional, Bowman, Christopher, additional, Killian, Jonathan K., additional, Wang, Shiyang, additional, Jackson, Twana, additional, Gorovets, Daniel, additional, Gorlick, Richard, additional, Thomas, Kristen, additional, Karajannis, Matthias, additional, and Snuderl, Matija, additional

Published
2018
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186. PDTM-49. GLOBAL REDUCTION IN H3K27me3, SIMILAR TO H3K27M MUTANT GLIOMAS, IS A MOLECULAR SURROGATE FOR PEDIATRIC POSTERIOR FOSSA- GROUP A EPENDYMOMAS

Author

Vennneti, Sriram, primary, Panwalkar, Pooja, additional, Clark, Jonathan, additional, Ramaswamy, Vijay, additional, Hawes, Debra, additional, Yang, Fusheng, additional, Dunham, Christopher, additional, Yip, Stephen, additional, Hukin, Juliette, additional, Sun, Yilun, additional, Schipper, Matthew, additional, Chavez, Lukas, additional, Margol, Ashley, additional, Pekmezci, Melike, additional, Chung, Chan, additional, Banda, Adam, additional, Bayliss, Jill, additional, Curry, Sarah, additional, Santi, Mariarita, additional, Rodriguez, Fausto, additional, Snuderl, Matija, additional, Karajannis, Matthias, additional, Saratsis, Amanda, additional, Horbinski, Craig M, additional, Kool, Marcel, additional, Pfister, Stefan M, additional, Taylor, Michael, additional, Hawkins, Cynthia, additional, Korshunov, Andrey, additional, and Judkins, Alexander, additional

Published
2017
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188. GENE-02. PERIPHERAL BLOOD DNA METHYLATION PROFILES IDENTIFY IDH1/2 MUTATION STATUS IN ADULTS WITH DIFFUSE GLIOMA

Author

Kloetgen, Andreas, primary, Serrano, Jonathan, additional, Patel, Seema, additional, Bowman, Christopher, additional, Shen, Guomiao, additional, Zagzag, David, additional, Karajannis, Matthias, additional, Golfinos, John, additional, Placantonakis, Dimitris, additional, Tsirigos, Aristotelis, additional, Chi, Andrew S, additional, and Snuderl, Matija, additional

Published
2017
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189. PDCT-20. FEASIBILITY AND SAFETY OF SURGICAL BIOPSY FOR PATIENTS WITH DIPG: PRELIMINARY RESULTS FROM DIPG-BATS

Author

Gupta, Nalin, primary, Goumnerova, Liliana, additional, Ayyanar, Kanya, additional, Gump, William, additional, Bendel, Anne, additional, Nagib, Mahmoud, additional, Bowers, Daniel, additional, Weprin, Bradley, additional, Bredlau, Amy-Lee, additional, Gururangan, Sridharan, additional, Fuchs, Herbert, additional, Cohen, Kenneth, additional, Jallo, George, additional, Dorris, Kathleen, additional, Handler, Michael, additional, Comito, Melanie, additional, Dias, Mark, additional, Fangusaro, Jason R, additional, Goldman, Stewart, additional, Tomita, Tadanori, additional, Alden, Tord, additional, DiPatri, Arthur, additional, Gardner, Sharon, additional, Karajannis, Matthias, additional, Harter, David, additional, Gauvain, Karen, additional, Limbrick, David, additional, Leonard, Jeffrey, additional, Geyer, J Russ, additional, Leary, Sarah, additional, Browd, Samuel, additional, Khatib, Ziad, additional, Ragheb, John, additional, Bhatia, Sanjiv, additional, MacDonald, Tobey, additional, Aguilera, Dolly, additional, Brahma, Barun, additional, Manley, Peter, additional, Chi, Susan, additional, Mueller, Sabine, additional, Banerjee, Anuradha, additional, Murray, Jeffrey, additional, Nazemi, Kellie, additional, Baird, Lissa, additional, Robison, Nathan, additional, Kiehna, Erin, additional, Krieger, Mark, additional, Sandler, Eric, additional, Aldana, Philipp, additional, Wang, Joanne, additional, Sood, Sandeep, additional, Neuberg, Donna, additional, Puligandla, Maneka, additional, Greenspan, Lianne, additional, Wright, Karen, additional, Prados, Michael, additional, Bandopadhayay, Pratiti, additional, Ligon, Keith, additional, and Kieran, Mark, additional

Published
2017
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190. DNA Methylation–Based Classifier for Accurate Molecular Diagnosis of Bone Sarcomas

Author

Wu, S. Peter, primary, Cooper, Benjamin T., additional, Bu, Fang, additional, Bowman, Christopher J., additional, Killian, J. Keith, additional, Serrano, Jonathan, additional, Wang, Shiyang, additional, Jackson, Twana M., additional, Gorovets, Daniel, additional, Shukla, Neerav, additional, Meyers, Paul A., additional, Pisapia, David J., additional, Gorlick, Richard, additional, Ladanyi, Marc, additional, Thomas, Kristen, additional, Snuderl, Matija, additional, and Karajannis, Matthias A., additional

Published
2017
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191. Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2

Author

Modrek, Aram S., primary, Golub, Danielle, additional, Khan, Themasap, additional, Bready, Devin, additional, Prado, Jod, additional, Bowman, Christopher, additional, Deng, Jingjing, additional, Zhang, Guoan, additional, Rocha, Pedro P., additional, Raviram, Ramya, additional, Lazaris, Charalampos, additional, Stafford, James M., additional, LeRoy, Gary, additional, Kader, Michael, additional, Dhaliwal, Joravar, additional, Bayin, N. Sumru, additional, Frenster, Joshua D., additional, Serrano, Jonathan, additional, Chiriboga, Luis, additional, Baitalmal, Rabaa, additional, Nanjangud, Gouri, additional, Chi, Andrew S., additional, Golfinos, John G., additional, Wang, Jing, additional, Karajannis, Matthias A., additional, Bonneau, Richard A., additional, Reinberg, Danny, additional, Tsirigos, Aristotelis, additional, Zagzag, David, additional, Snuderl, Matija, additional, Skok, Jane A., additional, Neubert, Thomas A., additional, and Placantonakis, Dimitris G., additional

Published
2017
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192. Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas

Author

Lassaletta, Alvaro, primary, Zapotocky, Michal, additional, Mistry, Matthew, additional, Ramaswamy, Vijay, additional, Honnorat, Marion, additional, Krishnatry, Rahul, additional, Guerreiro Stucklin, Ana, additional, Zhukova, Nataliya, additional, Arnoldo, Anthony, additional, Ryall, Scott, additional, Ling, Catriona, additional, McKeown, Tara, additional, Loukides, Jim, additional, Cruz, Ofelia, additional, de Torres, Carmen, additional, Ho, Cheng-Ying, additional, Packer, Roger J., additional, Tatevossian, Ruth, additional, Qaddoumi, Ibrahim, additional, Harreld, Julie H., additional, Dalton, James D., additional, Mulcahy-Levy, Jean, additional, Foreman, Nicholas, additional, Karajannis, Matthias A., additional, Wang, Shiyang, additional, Snuderl, Matija, additional, Nageswara Rao, Amulya, additional, Giannini, Caterina, additional, Kieran, Mark, additional, Ligon, Keith L., additional, Garre, Maria Luisa, additional, Nozza, Paolo, additional, Mascelli, Samantha, additional, Raso, Alessandro, additional, Mueller, Sabine, additional, Nicolaides, Theodore, additional, Silva, Karen, additional, Perbet, Romain, additional, Vasiljevic, Alexandre, additional, Faure Conter, Cécile, additional, Frappaz, Didier, additional, Leary, Sarah, additional, Crane, Courtney, additional, Chan, Aden, additional, Ng, Ho-Keung, additional, Shi, Zhi-Feng, additional, Mao, Ying, additional, Finch, Elizabeth, additional, Eisenstat, David, additional, Wilson, Bev, additional, Carret, Anne Sophie, additional, Hauser, Peter, additional, Sumerauer, David, additional, Krskova, Lenka, additional, Larouche, Valerie, additional, Fleming, Adam, additional, Zelcer, Shayna, additional, Jabado, Nada, additional, Rutka, James T., additional, Dirks, Peter, additional, Taylor, Michael D., additional, Chen, Shiyi, additional, Bartels, Ute, additional, Huang, Annie, additional, Ellison, David W., additional, Bouffet, Eric, additional, Hawkins, Cynthia, additional, and Tabori, Uri, additional

Published
2017
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193. Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss–Driven Tumorigenesis

Author

Cooper, Jonathan, primary, Xu, Qingwen, additional, Zhou, Lu, additional, Pavlovic, Milica, additional, Ojeda, Virginia, additional, Moulick, Kamalika, additional, de Stanchina, Elisa, additional, Poirier, John T., additional, Zauderer, Marjorie, additional, Rudin, Charles M., additional, Karajannis, Matthias A., additional, Hanemann, C. Oliver, additional, and Giancotti, Filippo G., additional

Published
2017
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194. Endothelium-Independent Primitive Myxoid Vascularization Creates Invertebrate-Like Channels to Maintain Blood Supply in Optic Gliomas

Author

Snuderl, Matija, primary, Zhang, Guoan, additional, Wu, Pamela, additional, Jennings, Tara S., additional, Shroff, Seema, additional, Ortenzi, Valerio, additional, Jain, Rajan, additional, Cohen, Benjamin, additional, Reidy, Jason J., additional, Dushay, Mitchell S., additional, Wisoff, Jeffrey H., additional, Harter, David H., additional, Karajannis, Matthias A., additional, Fenyo, David, additional, Neubert, Thomas A., additional, and Zagzag, David, additional

Published
2017
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195. Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

Author

Panwalkar, Pooja, primary, Clark, Jonathan, additional, Ramaswamy, Vijay, additional, Hawes, Debra, additional, Yang, Fusheng, additional, Dunham, Christopher, additional, Yip, Stephen, additional, Hukin, Juliette, additional, Sun, Yilun, additional, Schipper, Matthew J., additional, Chavez, Lukas, additional, Margol, Ashley, additional, Pekmezci, Melike, additional, Chung, Chan, additional, Banda, Adam, additional, Bayliss, Jill M., additional, Curry, Sarah J., additional, Santi, Mariarita, additional, Rodriguez, Fausto J., additional, Snuderl, Matija, additional, Karajannis, Matthias A., additional, Saratsis, Amanda M., additional, Horbinski, Craig M., additional, Carret, Anne-Sophie, additional, Wilson, Beverly, additional, Johnston, Donna, additional, Lafay-Cousin, Lucie, additional, Zelcer, Shayna, additional, Eisenstat, David, additional, Silva, Marianna, additional, Scheinemann, Katrin, additional, Jabado, Nada, additional, McNeely, P. Daniel, additional, Kool, Marcel, additional, Pfister, Stefan M., additional, Taylor, Michael D., additional, Hawkins, Cynthia, additional, Korshunov, Andrey, additional, Judkins, Alexander R., additional, and Venneti, Sriram, additional

Published
2017
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196. DIPG-29. GENOMIC LANDSCAPE OF DIFFUSE INTRINSIC PONTINE GLIOMA: AN ANALYSIS OF THE DIPG-BATS COHORT

Author

Bandopadhayay, Pratiti, primary, Greenwald, Noah F., additional, Wala, Jeremiah, additional, Sharpira, Ofer, additional, Tracy, Adam, additional, Filbin, Mariella, additional, O’Rourke, Ryan, additional, Ho, Patricia, additional, Sinai, Claire, additional, Malkin, Hayley, additional, Greenspan, Lianne, additional, Lawler, Kristen, additional, Pelton, Kristine, additional, Banerjee, Anu, additional, Becher, Oren, additional, Ayyanar, Kaynalakshmi, additional, Gump, William, additional, Bendel, Anne, additional, Bowers, Daniel C., additional, Nagib, Mahmoud, additional, Weprin, Bradley, additional, Bredlau, Amy-Lee, additional, Gururangan, Sridharan, additional, Fuchs, Herbert, additional, Cohen, Kenneth, additional, Comito, Melanie, additional, Dias, Mark, additional, Fangusaro, Jason, additional, Goldman, Stewart, additional, Elster, Jennifer D., additional, Fisher, Paul G., additional, Tomita, Tadanori, additional, Alden, Tord, additional, DiPatri, Arthur, additional, Gardner, Sharon, additional, Karajannis, Matthias, additional, Harter, David, additional, Handler, Michael H., additional, Gauvain, Karen, additional, Limbrick, David, additional, Leonard, Jeffrey, additional, Geyer, Russ, additional, Leary, Sarah E.S., additional, Khatib, Ziab, additional, Browd, Samuel, additional, Ragheb, John, additional, Bhatia, Sanjiv, additional, McDonald, Tobey, additional, Aguilera, Dolly, additional, Brahma, Barun, additional, Manley, Peter, additional, Wright, Karen D., additional, Chi, Susan, additional, Mueller, Sabine, additional, Murray, Jeff, additional, Nazemi, Kellie, additional, Baird, Lissa, additional, Monje, Michelle, additional, Robison, Nathan, additional, Kiehna, Erin, additional, Krieger, Mark, additional, Sandler, Eric, additional, Aldana, Philipp, additional, Rubin, Joshua, additional, Snuderl, Matija, additional, Wang, Zhihong Joanne, additional, Sood, Sandeep, additional, Neuberg, Donna, additional, Suva, Mario, additional, Segal, Rosalind, additional, Jabado, Nada, additional, Puligandla, Maneka, additional, Prados, Michael D., additional, Marcus, Karen, additional, Haas-Kogan, Daphne A., additional, Goumnerova, Liliana, additional, Gupta, Nalin, additional, Ligon, Keith, additional, Beroukhim, Rameen, additional, and Kieran, Mark, additional

Published
2017
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198. LGG-02. BIOCHEMICAL COMPOSITION AND BIOLOGICAL FUNCTION OF MYXOID MATRIX IN OPTIC GLIOMAS

Author

Snuderl, Matija, primary, Zhang, Guoan, additional, Wu, Pamela, additional, Jennings, Tara, additional, Shroff, Seema, additional, Ortenzi, Valerio, additional, Jain, Rajan, additional, Cohen, Benjamin, additional, Reidy, Jason, additional, Dushay, Mitchell, additional, Wisoff, Jeffrey, additional, Harter, David, additional, Karajannis, Matthias, additional, Fenyo, David, additional, Neubert, Thomas, additional, and Zagzag, David, additional

Published
2017
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199. TRTH-23. FEASIBILITY AND SAFETY OF SURGICAL BIOPSY FOR PATIENTS WITH DIPG: PRELIMINARY RESULTS FROM DIPG-BATS

Author

Gupta, Nalin, primary, Goumnerova, Liliana, additional, Ayyanar, Kanya, additional, Gump, William, additional, Bendel, Anne, additional, Nagib, Mahmoud, additional, Bowers, Daniel, additional, Weprin, Bradley, additional, Bredlau, Amy-Lee, additional, Gururangan, Sri, additional, Fuchs, Herbert, additional, Cohen, Ken, additional, Jallo, George, additional, Dorris, Katie, additional, Handler, Michael, additional, Comito, Melanie, additional, Dias, Mark, additional, Fangusaro, Jason, additional, Goldman, Stewart, additional, Tomita, Tadanori, additional, Alden, Tord, additional, DiPatri, Arthur, additional, Gardner, Sharon, additional, Karajannis, Matthias, additional, Harter, David, additional, Gauvain, Karen, additional, Limbrick, David, additional, Leonard, Jeff, additional, Geyer, Russ, additional, Leary, Sarah, additional, Browd, Samuel, additional, Khatib, Ziad, additional, Ragheb, John, additional, Bhatia, Sanjiv, additional, MacDonald, Tobey, additional, Aguilera, Dolly, additional, Brahma, Barun, additional, Manley, Peter, additional, Chi, Susan, additional, Mueller, Sabine, additional, Banerjee, Anu, additional, Murray, Jeff, additional, Nazemi, Kellie, additional, Baird, Lissa, additional, Robison, Nathan, additional, Kiehna, Erin, additional, Krieger, Mark, additional, Sandler, Eric, additional, Aldana, Philipp, additional, Wang, Joanne, additional, Sood, Sandeep, additional, Neuberg, Donna, additional, Puligandla, Maneka, additional, Greenspan, Lianne, additional, Wright, Karen, additional, Prados, Michael, additional, Bandopadhayay, Pratiti, additional, Ligon, Keith, additional, and Kieran, Mark, additional

Published
2017
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200. A DNA methylation-based classifier for accurate molecular diagnosis of bone sarcomas.

Author

Wu, Shengyang, primary, Cooper, Benjamin Thomas, additional, Bu, Fang, additional, Bowman, Christopher, additional, Killian, Keith, additional, Serrano, Jonathan, additional, Wang, Shiyang, additional, Jackson, Twana, additional, Gorovets, Daniel, additional, Gorlick, Richard Greg, additional, Ladanyi, Marc, additional, Thomas, Kristen, additional, Snuderl, Matija, additional, and Karajannis, Matthias A., additional

Published
2017
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