Search

Your search keyword '"Kang, Ho Won"' showing total 492 results
Start Over Author "Kang, Ho Won"
492 results on '"Kang, Ho Won"'

155. MP62-07 A COMPETING RISK ANALYSIS OF CANCER-SPECIFIC MORTALITY OF INITIAL TREATMENT WITH RADICAL PROSTATECTOMY VERSUS RADIATION THERAPY IN HIGH-RISK PROSTATE CANCER

Author

Lee, Joo Yong, primary, Choi, Jae Hyeok, additional, Kim, In Kyoung, additional, Jung, Hae Do, additional, Kang, Ho Won, additional, Yoon, Young Eun, additional, Ha, Ji Yong, additional, Cho, Kang Su, additional, Lee, Joong Shik, additional, Cho, In Rae, additional, and Choi, Young Deuk, additional

Published
2014
Full Text
View/download PDF

157. MP22-16 RECURRENCE RATE OF TRANSURETHRAL RESECTION OF BLADDER TUMOR USING NARROW BAND IMAGING: A RANDOMIZED CONTROL TRIAL, PILOT STUDY

Author

Lee, Joo Yong, primary, Choi, Jae Hyeok, additional, Kim, In Kyoung, additional, Jung, Hae Do, additional, Kang, Ho Won, additional, Lee, Ki Soo, additional, Yoon, Young Eun, additional, Ha, Ji Yong, additional, Cho, Kang Su, additional, Lee, Joong Shik, additional, Cho, In Rae, additional, and Choi, Young Deuk, additional

Published
2014
Full Text
View/download PDF

164. HOXA9,ISL1andALDH1A3methylation patterns as prognostic markers for nonmuscle invasive bladder cancer: Array-based DNA methylation and expression profiling

Author

Kim, Yong-June, primary, Yoon, Hyung-Yoon, additional, Kim, Ji Sang, additional, Kang, Ho Won, additional, Min, Byung-Dal, additional, Kim, Seon-Kyu, additional, Ha, Yun-Sok, additional, Kim, Isaac Yi, additional, Ryu, Keun Ho, additional, Lee, Sang-Cheol, additional, and Kim, Wun-Jae, additional

Published
2013
Full Text
View/download PDF

168. DecreasedDBC1Expression Is Associated With Poor Prognosis in Patients With Non-Muscle-Invasive Bladder Cancer

Author

Shim, Ui Jae, primary, Lee, Il-Seok, additional, Kang, Ho Won, additional, Kim, Jayoung, additional, Kim, Won Tae, additional, Kim, Isaac Yi, additional, Ryu, Keun Ho, additional, Choi, Yung Hyun, additional, Moon, Sung-Kwon, additional, Kim, Yong-June, additional, Yun, Seok-Joong, additional, Lee, Sang-Cheol, additional, and Kim, Wun-Jae, additional

Published
2013
Full Text
View/download PDF

174. Ca2+Regulation of Cav3.3 T-type Ca2+Channel Is Mediated by Calmodulin

Author

Lee, Narae, Jeong, Sua, Kim, Kang-Chang, Kim, Jin-Ah, Park, Jin-Yong, Kang, Ho-Won, Perez-Reyes, Edward, and Lee, Jung-Ha

Abstract

Calcium-dependent inactivation of high voltage-activated Ca2+channels plays a crucial role in limiting rises in intracellular calcium (Ca2+i). A key mediator of these effects is calmodulin, which has been found to bind the C-terminus of the pore-forming αsubunit. In contrast, little is known about how Ca2+ican regulate low voltage-activated T-type Ca2+channels. Using whole cell patch clamp, we examined the biophysical properties of Ca2+current through the three T-type Ca2+channel isoforms, Cav3.1, Cav3.2, or Cav3.3, comparing internal solutions containing 27 nM and l μM free Ca2+. Both activation and inactivation kinetics of Cav3.3 current in l μM Ca2+isolution were more rapid than those in 27 nM Ca2+isolution. In addition, both activation and steady-state inactivation curves of Cav3.3 were negatively shifted in the higher Ca2+isolution. In contrast, the biophysical properties of Cav3.1 and Cav3.2 isoforms were not significantly different between the two internal solutions. Overexpression of CaM1234(a calmodulin mutant that doesn’t bind Ca2+) occluded the effects of l μM Ca2+ion Cav3.3, implying that CaM is involved in the Ca2+iregulation effects on Cav3.3. Yeast two-hybrid screening and co-immunoprecipitation experiments revealed a direct interaction of CaM with the carboxyl terminus of Cav3.3. Taken together, our results suggest that Cav3.3 T-type channel is potently regulated by Ca2+ivia interaction of Ca2+/CaM with the carboxyl terminus of Cav3.3.

Published
2017
Full Text
View/download PDF

181. Granular Cell Tumor of the Urinary Bladder

Author

Kang, Ho-Won, primary, Kim, Young-Won, additional, Ha, Yun-Sok, additional, Min, Young-Ki, additional, Kim, Won-Tae, additional, Kim, Yong-June, additional, Yun, Seok-Joong, additional, Lee, Sang-Cheol, additional, and Kim, Wun-Jae, additional

Published
2010
Full Text
View/download PDF

183. Structural and biophysical determinants of single CaV3.1 and CaV3.2 T-type calcium channel inhibition by N2O

Author

Bartels, Peter, primary, Behnke, Kerstin, additional, Michels, Guido, additional, Groner, Ferdi, additional, Schneider, Toni, additional, Henry, Margit, additional, Barrett, Paula Q., additional, Kang, Ho-Won, additional, Lee, Jung-Ha, additional, Wiesen, Martin H.J., additional, Matthes, Jan, additional, and Herzig, Stefan, additional

Published
2009
Full Text
View/download PDF

189. Clinical Implications and Prognostic Values of Prostate Cancer Susceptibility Candidate Methylation in Primary Nonmuscle Invasive Bladder Cancer.

Author

Kim, Young-Won, Yoon, Hyung-Yoon, Seo, Sung Pil, Lee, Sang Keun, Kang, Ho Won, Kim, Won Tae, Bang, Heui Je, Ryu, Dong Hee, Yun, Seok-Joong, Lee, Sang-Cheol, Kim, Wun-Jae, and Kim, Yong-June

Subjects
PROSTATE cancer, DISEASE susceptibility, METHYLATION, BLADDER cancer, FOLLOW-up studies (Medicine)
Abstract

DNA methylation is the most common and well-characterized epigenetic change in human cancer. Recently, an association between prostate cancer susceptibility candidate (PRAC) methylation and genitourinary cancer was proposed. The aim of the present study was to evaluate the association between PRAC methylation status and clinicopathological parameters and prognosis in long-term follow-up primary nonmuscle invasive bladder cancer (NMIBC). The clinical relevance of PRAC methylation was determined in 136 human bladder specimens (eight normal controls [NCs] and 128 primary NMIBCs) using quantitative pyrosequencing analysis. PRAC methylation was significantly higher in NMIBC patients than in NCs and was significantly associated with higher grade and more advanced stage of cancer. Kaplan-Meier estimates revealed significant difference in tumor recurrence and progression according to PRAC methylation status (both p < 0.05). Multivariate Cox regression analysis revealed that the PRAC methylation status was a strong predictor of recurrence (hazard ratio [HR], 2.652; p = 0.012) and progression (HR, 9.531; p = 0.035) of NMIBC. Enhanced methylation status of PRAC was positively associated with a high rate of recurrence and progression in NMIBC patients, suggesting that PRAC methylation may be a promising prognostic marker of NMIBC. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

195. The predictive value of GSTT1 polymorphisms in predicting the early response to induction BCG therapy in patients with non–muscle invasive bladder cancer 1 [1] Basic Science Research Program, the National Research Foundation of Korea, funded by the Ministry of Education, Science and Technology (2011–0023308) and by a Grant from the Next-Generation BioGreen 21 Program (No. PJ008195), Rural Development Administration, Republic of Korea. The biospecimens for this study were provided by the Chungbuk National University Hospital, a member of the National Biobank of Korea, which is supported by the Ministry of Health, Welfare and Family Affairs. All samples derived from the National Biobank of Korea were obtained with informed consent under institutional review board–approved protocols.

Author

Kang, Ho Won, Tchey, Dong-Un, Yan, Chunri, Kim, Won Tae, Kim, Yong-June, Yun, Seok-Joong, Lee, Sang-Cheol, Choi, Yung Hyun, Kim, Isaac Yi, and Kim, Wun-Jae

Subjects
*BCG immunotherapy, *GLUTATHIONE transferase, *GENETIC polymorphisms, *BLADDER cancer patients, *BLADDER cancer treatment, *POLYMERASE chain reaction, *THERAPEUTICS
Abstract

Abstract: Introduction: We evaluated the predictive value of glutathione S transferase mu (GSTM1) and theta (GSTT1) polymorphisms in early response to bacillus Calmette-Guérin (BCG) induction therapy in patients with primary non–muscle invasive bladder cancer. Methods: GSTM1 and GSTT1 polymorphisms were analyzed by multiplex polymerase chain reaction using blood genomic DNA from 135 patients with primary non–muscle invasive bladder cancer who were being treated with a single induction course of BCG. BCG nonresponsiveness (early BCG failure) was defined as a tumor recurrence or progression within 12 months after BCG induction therapy. The predictive value of GST polymorphisms was evaluated by Kaplan-Meier analysis and multivariate logistic regression models. Results: Patients carrying a GSTT1-positive genotype demonstrated a higher likelihood of early BCG failure regardless of cigarette smoking. After stratification based on the tumor stage and grade, the high-risk group (T1G3) with a GSTT1-positive genotype showed a 14-fold higher risk of early BCG failure compared with those with a GSTT1-null genotype. In a combined analysis of 2 genes, the GSTT1-positive/GSTM1-null genotype had a higher risk of BCG nonresponsiveness compared with the GSTT1-null/GSTM1-null genotype (odds ratio = 4.17, 95% CI: 1.54–11.26). By multivariate logistic regression analysis, the GSTT1-positive genotype was an independent predictor of early BCG failure (odds ratio = 3.67, 95% CI: 1.61–8.38). Kaplan-Meier estimates revealed a significant difference in disease-free survival depending on the GSTT1 genotype (log rank test, P = 0.038). Conclusions: The results of this study suggest that the GSTT1-positive genotype is an independent predictor of early BCG failure. These results can help determine whether patients would benefit from adjuvant BCG treatment or may require more aggressive alternative therapies. [Copyright &y& Elsevier]

Published
2014
Full Text
View/download PDF

199. HOXA9, ISL1 and ALDH1A3 methylation patterns as prognostic markers for nonmuscle invasive bladder cancer: Array-based DNA methylation and expression profiling.

Author

Kim, Yong‐June, Yoon, Hyung‐Yoon, Kim, Ji Sang, Kang, Ho Won, Min, Byung‐Dal, Kim, Seon‐Kyu, Ha, Yun‐Sok, Kim, Isaac Yi, Ryu, Keun Ho, Lee, Sang‐Cheol, and Kim, Wun‐Jae

Abstract

DNA methylation patterns are associated with the development and prognosis of cancer. The aim of this study was to identify novel methylation markers for the prediction of patient outcomes using microarray analysis of DNA methylation and RNA expression patterns in samples from long-term follow-up patients with nonmuscle invasive bladder cancer (NMIBC). A total of 187 human bladder specimens were used for microarray array or pyrosequencing (PSQ) analyses: 6 normal controls (NC) and 181 NMIBC. Tumor-specific hypermethylated genes were selected from a data set comprising 24 matched microarray-based DNA methylation and gene expression profiles (6 controls and 18 NMIBC), and their clinical relevance was verified by quantitative PSQ analysis. The methylation status of Homeobox A9 (HOXA9), ISL LIM homeobox 1 (ISL1) and Aldehyde dehydrogenase 1 family, member A3 (ALDH1A3) was significantly associated with decreased gene expression levels and aggressive clinicopathological characteristics. Multivariate regression analyses showed that hypermethylation of these genes was an independent predictor of disease recurrence ( HOXA9, ISL1 and ALDH1A3, either alone or in combination) and progression ( ISL1 and ALDH1A3, either alone or in combination) (each p < 0.05). The results of this study suggest that these novel methylation markers are independent prognostic indicators in NMIBC patients, which may facilitate the assessment of disease recurrence and progression in NMIBC patients and inform clinical decision making regarding treatment. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

200. Natural History of Asymptomatic Renal Stones and Prediction of Stone Related Events.

Author

Kang, Ho Won, Lee, Sang Keun, Kim, Won Tae, Kim, Yong-June, Yun, Seok-Joong, Lee, Sang-Cheol, and Kim, Wun-Jae

Subjects
KIDNEY stones, NATURAL history, MEDICAL records, FOLLOW-up studies (Medicine), RISK management in business, BODY mass index
Abstract

Purpose: The appropriate management for asymptomatic renal stones remains unclear. We assessed the natural history and progression rate of such stones and identified clinical factors associated with an increased risk of stone related events. Materials and Methods: We retrospectively reviewed the medical records of 201 male and 146 female patients with asymptomatic renal stones. It was recommended that patients be followed every 6 months. Mean followup was 31 months (range 6 to 180). Patients were divided into 2 groups by stone related events, including spontaneous stone passage, flank pain, stone growth or the need for intervention during followup. Results: Spontaneous passage occurred in 101 patients (29.1%). Of the patients 186 (53.6%) and 161 (46.4%) did and did not have stone related events, respectively. Of the whole cohort 85 patients (24.5%) required intervention but only 4.6% needed surgery. At 19 months after diagnosis 50% of the patients had a symptom. Those with stone related events were more likely to be younger (mean ± SD age 46.6 ± 12.7 vs 49.3 ± 12.6 years) and male, and have a stone history (p = 0.047, 0.017 and 0.014, respectively). Male gender significantly decreased the probability of freedom from stone related events (log rank test p = 0.0135) and it was an independent predictor of stone related events (HR 1.521, p = 0.009). Younger patients, and those with smaller stones and no stone growth were more likely to experience spontaneous passage and less likely to undergo intervention (each p <0.05). Conclusions: Asymptomatic renal stones can be followed safely but long-term followup is necessary. Periodic followup and early intervention should be recommended in patients with risk factors. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results