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183. Serum iron deficiency and 25-hydroxyvitamin D deficiency as an independent risk factor for osteoporosis in postmenopausal Arab women

Author

Afnan Ghaleb, Saba Abdi, Sobhy Yakout, Syed Danish Hussain, Kaiser Wani, Mohammad Masoud, Abdullah Alnaami, and Nasser M. Al-Daghri

Subjects
Iron deficiency, Vitamin D deficiency, Osteoporosis, Postmenopausal, Arab women, Science (General), Q1-390
Abstract

Background: Iron deficiency and 25-hydroxyvitamin D (25(OH)D) deficiency are among the most common nutrient deficiencies in the world. Osteoporosis, a major bone disorder, is prevalent globally as well as in Saudi Arabia. The relationship between these micronutrient deficiencies with osteoporosis is less investigated. Hence, the current study aimed to determine the relationship between iron and 25(OH)D deficiencies among postmenopausal Saudi women with osteoporosis and their associations with bone biomarkers. Methodology: A total of 184 postmenopausal Saudi women ≥ 45 years old [N = 75 osteoporosis group; N = 109 without osteoporosis or control group] were enrolled in this cross-sectional study. Anthropometrics and bone mineral density were measured. Serum iron indices, 25(OH)D and bone biomarkers [β-carboxyterminal telopeptide of type 1 collagen (β-crosslap), osteocalcin (OC), osteoprotegerin (OPG), osteopontin (OPN) and bone-specific alkaline phosphatase (BsALP) were determined. Results: In all subjects, significant associations were observed between serum iron and OC (r = 0.19; p = 0.02) as well as OPN (r = 0.17; p = 0.05). Also, serum 25(OH)D was inversely associated with BsALP (r = −0.25; p = 0.02), and positively with β-crosslap (r = 0.38; p = 0.01). An inverse significant association was observed between 25(OH)D and OPG (r = −0.25; p = 0.01) in the control group and BsALP (r = −0.31; p = 0.02) in the osteoporosis group. Conclusion: Significant associations between circulating iron and 25(OH)D with select bone biomarkers were observed in postmenopausal Arab women with osteoporosis, suggesting that these micronutrients may affect bone metabolism.

Published
2021
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184. Psychological well-being during COVID-19 lockdown: Insights from a Saudi State University’s Academic Community

Author

Hanan A. Alfawaz, Kaiser Wani, Abdulaziz A. Aljumah, Dara Aldisi, Mohammed G.A. Ansari, Sobhy M. Yakout, Shaun Sabico, and Nasser M. Al-Daghri

Subjects
COVID-19, Mental health, Anxiety, Depression, Insomnia, Family bond, Science (General), Q1-390
Abstract

Objectives: Measures to control the on-going COVID-19 pandemic such as quarantine and social distancing, together with information overload about the sporadic spread of the disease have negatively impacted many individuals’ mental and psychosocial health. This study aimed to investigate the prevalence of self-reported mental health parameters and the coping mechanisms of employees and students in a Saudi State University. Methods: An online survey in both Arabic and English was launched targeting students, staff and faculty of King Saud University from May 11 to June 6, 2020, the peak of Saudi Arabia’s nationwide lockdown. A total of 1542 respondents (726 males and 816 females) aged 20–65 years old participated. Results: Majority of the respondents claimed to have suffered from anxiety (58.1%), depression (50.2%) and insomnia (32.2%) during the lockdown. On average, 65.3% respondents agreed that family bond strengthened during lockdown. Those in the highest quartile of family bonding score (Q4) were 41% [odds ratio (OR) and 95% confidence interval (CI) of 0.59 (0.39–0.87), p

Published
2021
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