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153. Additional file 3 of A longitudinal examination of objective neighborhood walkability, body mass index, and waist circumference: the REasons for Geographic And Racial Differences in Stroke study

Author

Lang, Ian-Marshall, Antonakos, Cathy L., Judd, Suzanne E., and Colabianchi, Natalie

Subjects
education, mental disorders, nutritional and metabolic diseases
Abstract

Additional file 3. Logistic regression models predicting the odds of being overweight/obese at follow-up

Published
2022
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155. APOL1 risk variants associated with serum albumin in a population-based cohort study

Author

Chaudhary, Ninad S, Tiwari, Hemant K., Hidalgo, Bertha A, Limdi, Nita A, Reynolds, Richard J, Cushman, Mary, Zakai, Neil A, Lange, Leslie, Judd, Suzanne E, Winkler, Cheryl A., Kopp, Jeffrey B, Gutiérrez, Orlando M., and Irvin, Marguerite R

Subjects
Adult, Cohort Studies, Risk Factors, Humans, Prospective Studies, Middle Aged, Renal Insufficiency, Chronic, Apolipoprotein L1, Article, Serum Albumin, Glomerular Filtration Rate
Abstract

The association of apolipoprotein L1 (APOL1) nephropathy risk variants (APOL1), unique to African-ancestry (African-American [AA]) populations, with systemic inflammation, a contributor to chronic kidney disease (CKD) and end-stage kidney disease (ESKD) is ill-defined. This study aimed to describe the role of inflammatory markers in the relationship between APOL1 and incident kidney outcomes using a prospective cohort study.APOL1 high-risk status under a recessive genetic model was studied in 10,605 AA adults aged ≥45 years from the Reasons for Geographic and Racial Differences in Stroke study. The primary variables of interest were inflammatory markers: C-reactive protein (mg/dL), white blood cell count (cells/mm3), and serum albumin (sALB) (mg/dL). High inflammation status was defined if at least one of these inflammatory markers exceeded clinical threshold. The association between APOL1 and biomarkers were assessed using regression models adjusting for age, sex, ancestry, hypertension, lipid medications, albumin-to-creatinine ratio, and estimated glomerular filtration rate (eGFR). Models were stratified by diabetes status. We identified incident ESKD using USRDS linkage, and we defined incident CKD as an eGFR60 mL/min/1.73 m2 and ≥25% decline in the eGFR and normal baseline eGFR and tested for mediation of APOL1 and outcomes by biomarkers using the causal inference approach.Among 7,151 participants with data available on all inflammation markers, 4,479 participants had ≥1 marker meeting the clinical threshold. APOL1 high-risk status was associated with lower adjusted odds of reduced sALB {odds ratio (OR) (95% confidence interval [CI]): 0.59 [0.36, 0.96])}, and this association was significant in people with diabetes (OR [95% CI]: 0.40 [0.18, 0.89]) but not in those without diabetes. There was no association of APOL1 high-risk status with other markers or high inflammation status. APOL1 was independently associated with ESKD (OR [95% CI] = 1.78 [1.28, 2.48]) and CKD (OR [95% CI] = 1.38 [1.00, 1.91]). On mediation analysis, the direct effect between APOL1 and ESKD strengthened after accounting for sALB, but the estimated mediated effect was not statistically significant (OR [95% CI]: 0.98 [0.92, 1.05], p = 0.58).APOL1 high-risk variants were associated with sALB. However, sALB did not statistically mediate the association between APOL1 and incident ESKD.

Published
2022

159. Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Author

Benjamin, Emelia J., Blaha, Michael J., Chiuve, Stephanie E., Cushman, Mary, Das, Sandeep R., Deo, Rajat, de Ferranti, Sarah D., Floyd, James, Fornage, Myriam, Gillespie, Cathleen, Isasi, Carmen R., Jiménez, Monik C., Jordan, Lori Chaffin, Judd, Suzanne E., Lackland, Daniel, Lichtman, Judith H., Lisabeth, Lynda, Liu, Simin, Longenecker, Chris T., Mackey, Rachel H., Matsushita, Kunihiro, Mozaffarian, Dariush, Mussolino, Michael E., Nasir, Khurram, Neumar, Robert W., Palaniappan, Latha, Pandey, Dilip K., Thiagarajan, Ravi R., Reeves, Mathew J., Ritchey, Matthew, Rodriguez, Carlos J., Roth, Gregory A., Rosamond, Wayne D., Sasson, Comilla, Towfighi, Amytis, Tsao, Connie W., Turner, Melanie B., Virani, Salim S., Voeks, Jenifer H., Willey, Joshua Z., Wilkins, John T., Wu, Jason HY., Alger, Heather M., Wong, Sally S., and Muntner, Paul

Published
2017
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160. Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015

Author

Forouzanfar, Mohammad H., Liu, Patrick, Roth, Gregory A., Ng, Marie, Biryukov, Stan, Marczak, Laurie, Alexander, Lily, Estep, Kara, Hassen Abate, Kalkidan, Akinyemiju, Tomi F., Ali, Raghib, Alvis-Guzman, Nelson, Azzopardi, Peter, Banerjee, Amitava, Bärnighausen, Till, Basu, Arindam, Bekele, Tolesa, Bennett, Derrick A., Biadgilign, Sibhatu, Catalá-López, Ferrán, Feigin, Valery L., Fernandes, Joao C., Fischer, Florian, Gebru, Alemseged Aregay, Gona, Philimon, Gupta, Rajeev, Hankey, Graeme J., Jonas, Jost B., Judd, Suzanne E., Khang, Young-Ho, Khosravi, Ardeshir, Kim, Yun Jin, Kimokoti, Ruth W., Kokubo, Yoshihiro, Kolte, Dhaval, Lopez, Alan, Lotufo, Paulo A., Malekzadeh, Reza, Melaku, Yohannes Adama, Mensah, George A., Misganaw, Awoke, Mokdad, Ali H., Moran, Andrew E., Nawaz, Haseeb, Neal, Bruce, Ngalesoni, Frida Namnyak, Ohkubo, Takayoshi, Pourmalek, Farshad, Rafay, Anwar, Rai, Rajesh Kumar, Rojas-Rueda, David, Sampson, Uchechukwu K., Santos, Itamar S., Sawhney, Monika, Schutte, Aletta E., Sepanlou, Sadaf G., Shifa, Girma Temam, Shiue, Ivy, Tedla, Bemnet Amare, Thrift, Amanda G., Tonelli, Marcello, Truelsen, Thomas, Tsilimparis, Nikolaos, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A., Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Vlassov, Vasiliy Victorovich, Vos, Theo, Westerman, Ronny, Yan, Lijing L., Yano, Yuichiro, Yonemoto, Naohiro, Zaki, Maysaa El Sayed, and Murray, Christopher J. L.

Published
2017
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162. Duration of employment within occupations and incident stroke in a US general population cohort 45 years of age or older (REGARDS study).

Author

Huynh, Tran B., McClure, Leslie A., Howard, Virginia J., Stafford, Monika M., Judd, Suzanne E., and Burstyn, Igor

Subjects
STROKE, STROKE patients, HEMORRHAGIC stroke, DISEASE risk factors, OLD age, ISCHEMIC stroke, DISABILITY retirement
Abstract

Background: The work environment can contribute to the risk of cardiovascular diseases (CVD) including stroke. Our objective was to identify occupations with elevated risk of stroke within the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Methods: We analyzed incident stroke outcomes (ischemic and hemorrhagic strokes) from 2003 to 2020 and employment characteristics of 13,659 adults aged ≥45 years enrolled in a national population‐based cohort study. Using a modified Poisson regression approach, we estimated the relative risks (RRs) and the associated 95% confidence intervals (CI) of stroke in relation to years of employment within each occupation coded using the US Census two‐digit Standard Occupation Code. Models were adjusted for Framingham Stroke Risk Score, region, race, age, and body mass index. We conducted stratified analysis by sex, employment time period (pre‐1975 vs. post‐1975), and region. Results: Workers in the following occupations had a greater risk of stroke with longer duration of employment (per decade): protective service (RR: 2.35, 95% CI: 1.11, 4.97), food preparation and service (RR: 1.51, 95% CI: 1.05, 2.19), and transportation and material moving (RR: 1.30, 95% CI: 1.00, 1.69). The stroke risk in these occupations was disproportionately elevated in men, and differed by region and employment time period. Conclusions: Longer employment in protective service, food preparation and serving, and transportation and materials moving occupations may increase the risk of stroke. Surveillance may uncover specific work‐related risk factors in these occupations, leading to interventions to reduce the burden of stroke among US workers. [ABSTRACT FROM AUTHOR]

Published
2023
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164. Nucleosides Associated With Incident Ischemic Stroke in the REGARDS and JHS Cohorts

Author

Ament, Zsuzsanna, primary, Patki, Amit, additional, Chaudhary, Ninad, additional, Bhave, Varun M., additional, Garcia Guarniz, Ana-Lucia, additional, Gao, Yan, additional, Gerszten, Robert E., additional, Correa, Adolfo, additional, Judd, Suzanne E., additional, Cushman, Mary, additional, Long, D. Leann, additional, Irvin, M. Ryan, additional, and Kimberly, W. Taylor, additional

Published
2022
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165. Abstract P116: Hypertension Severity As Quantified By Hypertension Daily Dose (HDD) And Blood Pressure And Risk Of Stroke In The REGARDS Study

Author

Loo, Ying K, primary, Wilkinson, Katherine, additional, Harkness, Tyler A, additional, Howard, George, additional, Howard, Virginia J, additional, Judd, Suzanne E, additional, Zakai, Neil A, additional, Muntner, Paul, additional, Min, Lillian, additional, Oparil, Suzanne, additional, and Plante, Timothy B, additional

Published
2022
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169. Abstract P092: Cell Adhesion Molecules And Incident Hypertension In Black And White Adults: The REasons For Geographic And Racial Differences In Stroke (REGARDS) Study

Author

Harkness, Tyler A, primary, Wilkinson, Katherine, additional, Loo, Ying, additional, Howard, George, additional, Howard, Virginia J, additional, Cushman, Mary, additional, Zakai, Neil A, additional, Cheung, Katharine L, additional, Judd, Suzanne E, additional, and Plante, Timothy B, additional

Published
2022
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170. Abstract P050: Transcending The Geographical Barrier: Design And Preliminary Findings From The Mhealth Component Of The Rural Study

Author

Mehawej, Jordy, primary, Aditi, Singh, additional, Mathew, Joanne, additional, Evans, Megan, additional, Valpady, Shivakumar, additional, Bigliardo, Massimo, additional, Martin, Corby K, additional, Judd, Suzanne E, additional, Ramachandran, Vasan S, additional, McManus, David D, additional, and Soni, Apurv, additional

Published
2022
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174. APOL1 Risk Variants Associated with Serum Albumin in a Population-Based Cohort Study

Author

Chaudhary, Ninad S., primary, Tiwari, Hemant K., additional, Hidalgo, Bertha A., additional, Limdi, Nita A., additional, Reynolds, Richard J., additional, Cushman, Mary, additional, Zakai, Neil A., additional, Lange, Leslie, additional, Judd, Suzanne E., additional, Winkler, Cheryl A., additional, Kopp, Jeffrey B., additional, Gutiérrez, Orlando M., additional, and Irvin, Marguerite R., additional

Published
2022
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176. Abstract 11263: Multiple Inflammation Biomarkers and Incident Coronary Heart Disease Risk Among Black and White US Adults: The REGARDS Study

Author

Akinyelure, Oluwasegun P, primary, Colantonio, Lisandro, additional, Chaudhary, Ninad S, additional, Judd, Suzanne E, additional, Cushman, Mary, additional, Zakai, Neil, additional, Kabagambe, Edmond K, additional, Howard, Virginia J, additional, Safford, Monika, additional, and Irvin, Marguerite M, additional

Published
2021
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194. JAH-20-517.R1_APPENDIX_A_SUPPLEMENTAL_MODEL_TABLES_4_and_5 – Supplemental Material for The Association of Neighborhood Medical Facilities with Aging in Place and Risk of Incident Myocardial Infarction

Author

Brown, Janene R., Hirsch, Jana A., Judd, Suzanne E., Hurvitz, Philip M., Howard, Virginia J., Safford, Monika, Moore, Jeffrey, and Lovasi, Gina S.

Subjects
FOS: Clinical medicine, 111799 Public Health and Health Services not elsewhere classified, FOS: Health sciences, 110306 Endocrinology, 110308 Geriatrics and Gerontology
Abstract

Supplemental Material, JAH-20-517.R1_APPENDIX_A_SUPPLEMENTAL_MODEL_TABLES_4_and_5 for The Association of Neighborhood Medical Facilities with Aging in Place and Risk of Incident Myocardial Infarction by Janene R. Brown, Jana A. Hirsch, Suzanne E. Judd, Philip M. Hurvitz, Virginia J. Howard, Monika Safford, Jeffrey Moore and Gina S. Lovasi in Journal of Aging and Health

Published
2021
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195. Additional file 2 of Health care experiences during the COVID-19 pandemic by race and social determinants of health among adults age ��� 58 years in the REGARDS study

Author

Levitan, Emily B., Howard, Virginia J., Cushman, Mary, Judd, Suzanne E., Tison, Stephanie E., Yuan, Ya, Kamin Mukaz, Debora, Wang, Henry E., Pamir, Nathalie, Plante, Timothy B., Juraschek, Stephen P., Safford, Monika M., and Goyal, Parag

Abstract

Additional file 2. Health care experiences during the COVID-19 pandemic by race and social determinants of health among adults age ��� 58 years in the REGARDS Study.

Published
2021
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196. Additional file 1 of Health care experiences during the COVID-19 pandemic by race and social determinants of health among adults age ��� 58 years in the REGARDS study

Author

Levitan, Emily B., Howard, Virginia J., Cushman, Mary, Judd, Suzanne E., Tison, Stephanie E., Yuan, Ya, Kamin Mukaz, Debora, Wang, Henry E., Pamir, Nathalie, Plante, Timothy B., Juraschek, Stephen P., Safford, Monika M., and Goyal, Parag

Abstract

Additional file 1. REGARDS Computer-Assisted Telephone Interview CATI ��� COVID-19. REGARDS COVID-19 module administered beginning July 6, 2020.

Published
2021
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200. Abstract MP50: Neighborhood Social And Economic Environment And Heart Failure Risk Among Adults With & Without Diabetes: The Reasons For Geographic And Racial Differences In Stroke (regards) Study

Author

Malla, Gargya, primary, Cherrington, Andrea, additional, Safford, Monika M, additional, Goyal, Parag, additional, Cummings, Doyle M, additional, McAlexander, Tara, additional, De Silva, Shanika, additional, Judd, Suzanne E, additional, Hidalgo, Bertha, additional, Levitan, Emily B, additional, and Carson, April P, additional

Published
2021
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