1,966 results on '"Jie, Tao"'
Search Results
152. Reliable Control for Two-Dimensional Systems Subject to Extended Dissipativity.
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Jie Tao, Zheng-Guang Wu, Hongye Su, and Yuanqing Wu 0003
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- 2020
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153. A second-order cone programming based robust data envelopment analysis model for the new-energy vehicle industry.
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Chao Lu, Jie Tao, Qiuxian An, and Xiao-Dong Lai
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- 2020
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154. Target tracking methods based on a signal-to-noise ratio model.
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Dai Liu, Yong-Bo Zhao 0001, Ziqian Yuan, Jie-tao Li, and Guo-ji Chen
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- 2020
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155. The Power Setting of Focused Ultrasound for the Palliative Treatment of Advanced Pancreatic Cancer: A Study in an Ex Vivo Bovine Liver
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Shiqi Tong, Yuebing Wang, Peng Zhao, Jie Tao, Xiaoan Guo, and Yaping Yu
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pancreatic cancer ,palliative treatment ,moderate-intensity focused ultrasound ,temperature ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
High-intensity focused ultrasound (HIFU) ablation has been widely used in advanced pancreatic cancer in recent years. In numerous studies, HIFU has been shown to be safe, effective, and practicable, but there are a few HIFU-related adverse effects. The patients’ discomfort during therapy increased proportionally with increasing delivered energy and pain levels seemed to be independent of the dose of anesthetic or sedation. If the power used in therapy is too high, the temperature of the target area will rise rapidly, and the boiling and cavitation make the shape of the necrosis area difficult to control. In recent years, moderate-intensity focused ultrasound (MIFU) has also been shown to heat the tumor locally for palliative treatment. Choosing the appropriate power and effectively controlling the tissue temperature until reaching the threshold for thermal necrosis are of great significance for ensuring the safety of palliative treatment. In this study, an infrared temperature measurement experimental system was set up to measure the temperature rise at different power in an ex vivo bovine liver. It was found that when the acoustic intensity of the focused ultrasound was lower than the cavitation threshold (within the range of the MIFU), the temperature of the tissue kept rising at a steady rate and could still reach the thermal damage threshold temperature within tens of seconds. The results showed that the temperature induced by the MIFU was almost entirely dependent on the thermal effect, and the temperature of the tissue at the end of sonication was linearly related to the power. Finally, this study considered the effect of blood perfusion on the temperature for the application of focused ultrasound in the palliative treatment of advanced pancreatic cancer with the goal of providing a reference for the application of focused ultrasound in the palliative treatment of advanced pancreatic cancer.
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- 2022
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156. The Zuo Jin Wan Formula increases chemosensitivity of human primary gastric cancer cells by AKT mediated mitochondrial translocation of cofilin-1
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SUN, Meng-Yao, WANG, Dan-Dan, SUN, Jian, ZHAO, Xiao-Hua, CAI, Si, WU, Qiu-Xue, JIE, Tao, NI, Zhen-Hua, SUN, Jian-Yue, and TANG, Qing-Feng
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- 2019
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157. MicroRNA-221-3p Suppresses the Microglia Activation and Seizures by Inhibiting of HIF-1α in Valproic Acid-Resistant Epilepsy
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Meng Fu, Yiqing Zhu, Junqi Zhang, Wei Wu, Yunxia Sun, Xuemei Zhang, Jie Tao, and Zhiping Li
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valproic acid-resistant epilepsy ,microRNA-221-3p ,hypoxia-inducible factor-1α ,microglia ,neuroinflammation ,Therapeutics. Pharmacology ,RM1-950 - Abstract
One-third of patients with epilepsy suffer from drug-resistant epilepsy (DRE). Valproic acid (VPA) is a classic anticonvulsant drug, and its resistance is a crucial predictor of DRE, but the pathogenesis remain unknown. Most patients with VPA-resistant epilepsy appear distinct inflammatory response and local hypoxia. Hypoxia-inducible factor (HIF)-1α is an essential effector molecule of hypoxia and inflammation, and may exert therefore a significant effect on the development of VPA-resistant epilepsy. We systematically assess the significance of HIF-1α on children and mice with VPA-resistant epilepsy, and investigated the micro (mi) RNAs that regulate HIF-1α expression. We established models of VPA-sensitive epilepsy and VPA-resistant epilepsy in mice, and confirmed that they had significant differences in epileptic behavior and electroencephalography data. Through proteomics analysis, we identified that HIF-1α was overexpressed in mice with VPA-resistant epilepsy, and regulated the expression of interleukin-1β and tumor necrosis factor-α. Increased expression of HIF-1α led to the increase of microglia and induced their polarization from the M2 phenotype to M1 phenotype, which triggered the release of proinflammatory mediators. Bioinformatics analysis of public databases demonstrated that miR-221-3p was reduced in VPA-resistant epilepsy, and negatively regulated HIF-1α expression. Intervention using miR-221-3p mimics reduced HIF-1α expression markedly and suppressed the activation of microglia and the release of inflammatory mediators, which relieved epileptic seizures of VPA-resistant epilepsy. These observations reveal miR-221-3p/HIF-1α as essential component in pathogenesis of VPA-resistant epilepsy which represent therapeutic antiseizure targets.
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- 2021
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158. Effects of Perioperative Probiotics and Synbiotics on Pancreaticoduodenectomy Patients: A Meta-Analysis of Randomized Controlled Trials
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Gang Tang, Linyu Zhang, Jie Tao, and Zhengqiang Wei
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alternative therapy ,microorganisms ,postoperative infection ,pancreaticoduodenectomy ,probiotics ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Post-pancreaticoduodenectomy infections cause mortality, morbidity, and prolonged antibiotic use. Probiotics or synbiotics may be advantageous for preventing postoperative infections, but their benefits on pancreaticoduodenectomy outcomes are controversial. This study evaluated the efficacy of probiotics and synbiotics in pancreaticoduodenectomy. The Embase, Web of Science, PubMed, and Cochrane Library databases were comprehensively searched for randomized controlled trials (RCTs) that evaluated the effects of probiotics or synbiotics on pancreaticoduodenectomy as of April 16, 2021. Outcomes included perioperative mortality, postoperative infectious complications, delayed gastric emptying, hospital stay length, and antibiotic-use duration. The results were reported as mean differences (MDs) and relative risks (RRs) with 95% confidence intervals (CI). Six RCTs involving 294 subjects were included. Probiotic or synbiotic supplementation did not reduce the perioperative mortality (RR, 0.34; 95% CI, 0.11, 1.03), but reduced the incidences of postoperative infection (RR, 0.49; 95% CI, 0.34, 0.70) and delayed gastric emptying (RR, 0.27; 95% CI, 0.09, 0.76) and also reduced the hospital stay length (MD, −7.87; 95% CI, −13.74, −1.99) and antibiotic-use duration (MD, −6.75; 95% CI, −9.58, −3.92) as compared to the controls. Probiotics or synbiotics can prevent infections, reduce delayed gastric emptying, and shorten the hospital stay and antibiotic-use durations in patients undergoing pancreaticoduodenectomy. These findings are clinically important for promoting recovery from pancreaticoduodenectomy, reducing the incidences of antibiotic resistance and iatrogenic infections, and reducing the medical burden.
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- 2021
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159. Toward multi-label sentiment analysis: a transfer learning based approach
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Jie Tao and Xing Fang
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Transfer learning ,Multi-label classification ,Sentiment analysis ,Natural language processing ,Deep learning ,Computer engineering. Computer hardware ,TK7885-7895 ,Information technology ,T58.5-58.64 ,Electronic computers. Computer science ,QA75.5-76.95 - Abstract
Abstract Sentiment analysis is recognized as one of the most important sub-areas in Natural Language Processing (NLP) research, where understanding implicit or explicit sentiments expressed in social media contents is valuable to customers, business owners, and other stakeholders. Researchers have recognized that the generic sentiments extracted from the textual contents are inadequate, thus, Aspect Based Sentiment Analysis (ABSA) was coined to capture aspect sentiments expressed toward specific review aspects. Existing ABSA methods not only treat the analytical problem as single-label classification that requires a fairly large amount of labelled data for model training purposes, but also underestimate the entity aspects that are independent of certain sentiments. In this study, we propose a transfer learning based approach tackling the aforementioned shortcomings of existing ABSA methods. Firstly, the proposed approach extends the ABSA methods with multi-label classification capabilities. Secondly, we propose an advanced sentiment analysis method, namely Aspect Enhanced Sentiment Analysis (AESA) to classify text into sentiment classes with consideration of the entity aspects. Thirdly, we extend two state-of-the-art transfer learning models as the analytical vehicles of multi-label ABSA and AESA tasks. We design an experiment that includes data from different domains to extensively evaluate the proposed approach. The empirical results undoubtedly exhibit that the proposed approach outperform all the baseline approaches.
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- 2020
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160. Generative AI for Intelligence Augmentation: Categorization and Evaluation Frameworks for Large Language Model Adaptation.
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Jie Tao, Lina Zhou, and Xing Fang
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LANGUAGE models ,GENERATIVE artificial intelligence ,STAGE adaptations ,SOCIAL interaction ,CLASSIFICATION - Abstract
Generative AI (GenAI) has transformed how businesses operate and innovate and how individuals learn, live, and work. Large language models (LLMs), a specific type of GenAI, focus on generating human-like text based on user instructions. Like other types of GenAI, LLMs have received wide recognition for their potential to augment human intelligence, but several challenges hinder efforts to realize their full potential in practice. Some notable challenges include not adequately exploring LLM applications beyond chatbots and/or text generation, the difficulty in categorizing various LLM adaptation strategies (particularly regarding human interactions), and the lack of a reference framework for evaluating and selecting LLM adaptation strategies from a human-centered perspective. To address these challenges, we propose a categorization framework for LLM adaptation that features two human-centered dimensions and stage LLM adaptation with respect to when it interacts with human intelligence. Additionally, we introduce an evaluation framework that incorporates a human-centered perspective that goes beyond the common machine-centered measures. Our empirical investigations, in which we use text classification as use cases, not only demonstrate the application of these frameworks but also compare various adaptation strategies. These artifacts and findings provide fresh insights and practical recommendations for selecting effective adaptation strategies to improve the efficacy of LLMs for intelligence augmentation. We further identify future research issues to address current limitations and suggest improvements for the proposed frameworks. [ABSTRACT FROM AUTHOR]
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- 2024
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161. The tyrosine 73 and serine 83 dephosphorylation of H1N1 swine influenza virus NS1 protein attenuates virus replication and induces high levels of beta interferon
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Jinghua Cheng, Jie Tao, Benqiang Li, Ying Shi, and Huili Liu
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Swine influenza virus ,NS1 protein ,Phosphorylation ,Interferon responses ,RIG-I ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Nonstructural protein 1 (NS1) is a virulence factor encoded by influenza A virus (IAV) that is expressed in the nucleus and cytoplasm of host cells during the earliest stages of infection. NS1 is a multifunctional protein that plays an important role in virus replication, virulence and inhibition of the host antiviral immune response. However, to date, the phosphorylation sites of NS1 have not been identified, and the relationship between phosphorylation and protein function has not been thoroughly elucidated. Method In this study, potential phosphorylation sites in the swine influenza virus (SIV) NS1 protein were bioinformatically predicted and determined by Phos-tag SDS-PAGE analysis. To study the role of NS1 phosphorylation sites, we rescued NS1 mutants (Y73F and S83A) of A/swine/Shanghai/3/2014(H1N1) strain and compared their replication ability, cytokine production as well as the intracellular localization in cultured cells. Additionally, we used small interfering RNA (siRNA) assay to explore whether changes in the type I IFN response with dephosphorylation at positions 73 and 83 were mediated by the RIG-I pathway. Results We checked 18 predicted sites in 30 SIV NS1 genes to exclude strain-specific sites, covering H1N1, H1N2 and H3N2 subtypes and identified two phosphorylation sites Y73 and S83 in the H1N1 SIV protein by Phos-tag SDS-PAGE analysis. We found that dephosphorylation at positions 73 and 83 of the NS1 protein attenuated virus replication and reduced the ability of NS1 to antagonize IFN-β expression but had no effect on nuclear localization. Knockdown of RIG-I dramatically impaired the induction of IFN-β and ISG56 in NS1 Y73F or S83A mutant-infected cells, indicating that RIG-I plays a role in the IFN-β response upon rSIV NS1 Y73F and rSIV NS1 S83A infection. Conclusion We first identified two functional phosphorylation sites in the H1N1 SIV protein: Y73 and S83. We found that dephosphorylation at positions 73 and 83 of the NS1 protein affected the antiviral state in the host cells, partly through the RIG-I pathway.
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- 2019
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162. Reliability of synovial fluid alpha-defensin and leukocyte esterase in diagnosing periprosthetic joint infection (PJI): a systematic review and meta-analysis
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Yisheng Chen, Xueran Kang, Jie Tao, Yunpeng Zhang, Chenting Ying, and Weiwei Lin
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α-Defensin ,Leukocyte esterase ,Periprosthetic joint infection ,Meta ,Orthopedic surgery ,RD701-811 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Synovial fluid proteins had been applied as diagnostic biomarkers for periprosthetic joint infection (PJI) in recent research papers. Thus, this meta-analysis aimed to estimate the diagnostic efficiency of synovial fluid α-defensin and leukocyte esterase (LE) for PJI. Methods We conducted our systematic review by searching the keywords in online databases such as PubMed, Embase, Cochrane, Elsevier, Springer, and Web of Science from the time of database inception to October 2018. Inclusion criteria were as follows: patients who have undergone knee, hip, or shoulder joint replacements; α-defensin or leukocyte esterase (LE strip) of synovial fluid was detected as the biomarker for PJI diagnosis; and Musculoskeletal Infection Society (MSIS) or utilizing a combination of clinical data was considered as the gold standard. Diagnostic parameters including sensitivity, specificity, diagnostic odds ratio (DOR), and area under the summary of receiver operating characteristics curve (AUSROC) were calculated for the included studies to evaluate the synovial fluid α-defensin and LE for PJI diagnosis. Results After full-text review, 28 studies were qualified for this systematic review, 16 studies used α-defensin and the other 12 were conducted using LE strip. The pooled sensitivity, specificity, and DOR of LE strip were 87% (95% CI 84–90%), 96% (95% CI 95–97%), and 170.09 (95% CI 97.63–296.32), respectively, while the pooled sensitivity, specificity, and DOR of α-defensin were 87% (95% CI 83–90%), 97% (95% CI 96–98%), and 158.18 (95% CI 74.26–336.91), respectively. The AUSROC for LE strip and α-defensin were 0.9818 and 0.9685, respectively. Conclusion Both LE strip and α-defensin of synovial fluid provide rapid and convenient diagnosis for PJI. Sensitivity of α-defensin and LE strip are the same, while both these two methods have high specificity in clinical practice.
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- 2019
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163. Rational application of the first‐line chemotherapy and immune checkpoint inhibitors in advanced nonsmall cell lung cancer: A meta‐analysis
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Rui Cao, Jie‐Tao Ma, Shu‐Ling Zhang, Li Sun, Yang Liu, Xiang‐Yan Zhang, Wei Jing, Le‐Tian Huang, and Cheng‐Bo Han
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chemotherapy ,immunotherapy ,meta‐analysis ,nonsmall cell lung cancer ,programmed death‐ligand 1 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Objective To compare the relative efficacy of immune checkpoint inhibitors (ICIs) or chemotherapy (CT) alone, or their combination modality in the first‐line treatment of advanced nonsmall cell lung cancer (NSCLC). Methods This meta‐analysis was performed on the eligible randomized controlled trials (RCTs) after searching web databases and meeting abstracts. The main research endpoints were the comparisons of median overall survival (mOS), the OS rate of 6 months (OSR6m), 1 year (OSR1y) and 2 years (OSR2y), median progression‐free survival (mPFS), the PFS rate of 6 months (PFSR6m) and 1‐year (PFSR1y), objective response rates (ORR), and treatment‐related adverse events (TRAEs). Results Eleven RCTs comprising 6278 cases were included. In the subgroup of programmed death‐ligand 1 (PD‐L1) ≥50%, compared with chemotherapy, the ICIs showed similar OSR6m (P > 0.05), but significantly improved efficacy in mOS, OSR1y, OSR2y, and ORR (all P 0.05), but significantly improved mPFS, PFSR6m, and ORR (all P
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- 2019
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164. Distribution and Migration Characteristics of Selenium in the Soil-Plant System of Paddy Fields in the Pearl River Delta, Yamen Town
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GU Tao, ZHAO Xin-wen, LEI Xiao-qing, HUANG Chang-sheng, ZENG Min, LIU Xue-hao, and WANG Jie-tao
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paddy field ,selenium ,atomic fluorescence spectrometry ,soil-plant system ,distribution ,migration ,Geology ,QE1-996.5 ,Ecology ,QH540-549.5 - Abstract
BACKGROUND The distribution and migration of selenium in the natural environment is a hot topic. The results of a multi-purpose, regional, geochemical survey showed that the content of selenium in the Pearl River Delta Region soils was relatively high, which was suitable for the planting of selenium-rich agricultural products. However, the rule of selenium migration and transformation in the soil-plant system is not yet clear. OBJECTIVES To understand the distribution and migration of selenium in the soil-plant system. METHODS Taking Yamen Town, Jiangmen City, a typical selenium-rich area in the Pearl River Delta region as an example, selenium contents in rocks, weathered soils, paddy soils, shallow groundwater, irrigation water and rice samples were analyzed by atomic fluorescence spectrometry. RESULTS The mean selenium concentrations in the granite rocks, granite weathered soils, surface soils, profile soils, shallow groundwater, irrigation water and rice of Yamen Town were 0.0208mg/kg, 0.2325mg/kg, 0.5060mg/kg, 0.83mg/kg, 0.0003mg/L, 0.0004mg/L and 0.058mg/kg, respectively. The selenium contents in surface soils were equivalent to the soil background value of the Pearl River Delta (0.51mg/kg), the selenium contents of rice reached the standard of selenium-rich rice. CONCLUSIONS The rules of selenium migration in the soil-plant system are as follows:selenium migrates downward in the soil profiles, and migrates downstream along the direction of groundwater runoff. Soil selenium migrates to rice root easily, but migrates with difficulty from roots to the overground parts of rice. The study on the distribution and migration of selenium in the soil-plant system can provide a scientific basis for the exploitation and utilization of selenium-rich resources in this area.
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- 2019
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165. Managing for Citizen Satisfaction: Is Good Not Enough?
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Brian K. Collins, Hyun Joon Kim, and Jie Tao
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Citizen Satisfaction ,Service Quality ,Service Quantity ,Performance Measurement ,Equity ,Political institutions and public administration (General) ,JF20-2112 - Abstract
Citizen satisfaction is a popular means of performance management. It underscores a common conception that citizens are customers who are concerned about the quality of public goods and services. We offer a theory that suggests the quantity of public goods and services is also important. We develop our theory based on democratic models of the public where citizens are concerned about equity and accessibility to public goods and services. Using data from two municipal surveys and Structural Equation Modeling (SEM), we test three hypotheses and find that both quality and quantity of public service provision are significant antecedents to citizen satisfaction. In our conclusion, we explain how these results call for a more complex conceptualization of the performance associated with managing for citizen satisfaction, and we recommend public managers develop and employ skills that recognize the complex consumptive and democratic attributes of citizens in a public economy.
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- 2019
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166. Effect of Active Deflection on the Forming of Tubes Manufactured by 3D Free Bending Technology
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Hao Zhang, Ali Abd El-Aty, Jie Tao, Xunzhong Guo, Shuo Zheng, and Cheng Cheng
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free bending ,active deflection ,trajectory radius ,mold structure ,Mining engineering. Metallurgy ,TN1-997 - Abstract
The formed parts of tubes easily interfere with the equipment when forming complex tubes in 3D free bending forming technology. Consequently, to solve the interferential phenomenon, an active deflection method (ADM) to avoid interference was proposed to drive the deformed tube around its axis by controlling the bending die. The method extended the activity freedom of the equipment without installing the additional motion shafting. However, severe section distortion, surface scratches and other forming defects frequently occurred during the implementation of ADM, which reduced the structural strength and pressure resistance of the tubes. A mechanical model was developed to analyze the force state of the tube, and the results showed that the driving force of active deflection was mainly determined by the trajectory radius. The curve of the adopted bell-shaped transition structure was closer to the bending curvature of the tube than the rounded structure, which transformed the guider and the tube from linear contact to surface contact. The simulation and experiment results indicated that adding the trajectory radius could strengthen the rotation torque. The stress concentration in the tube was alleviated after applying the bell-shaped transition structure.
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- 2022
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167. Elucidating the Chemical Compositions and Source Apportionment of Multi-Size Atmospheric Particulate (PM10, PM2.5 and PM1) in 2019–2020 Winter in Xinxiang, North China
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Huanjia Liu, Mengke Jia, Ke You, Jingjing Wang, Jie Tao, Hengzhi Liu, Ruiqin Zhang, Lanqing Li, Mengyuan Xu, Yan Ren, Yijie Zhao, Yongli Liu, Ke Cheng, Yujuan Fan, and Juexiu Li
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multi-size airborne particles ,chemical species ,source apportionment ,potential source contribution function ,Xinxiang ,Meteorology. Climatology ,QC851-999 - Abstract
The pollution characteristics of multi-size atmospheric particulates in Xinxiang, which was one of the most polluted cities across China, are still unclear even through air quality in Xinxiang has been improved in recent years. PM10, PM2.5, and PM1 samples were synchronously collected from 21 December 2019 to 17 January 2020 to explore pollution levels and reveal sources of PM in Xinxiang. The average mass concentrations of PM10, PM2.5, and PM1 were as high as 155.53 μg m−3, 120.07 μg m−3, and 85.64 μg m−3 during the observation period, respectively. Almost all of the chemical compositions in PM10, PM2.5 and PM1 increased continuously and obviously with the aggravation of the pollution level. Compared with the clean period, the enhancement of sulfate (23–27%) in PM was obvious higher than nitrate (19–22%) during the pollution period, which demonstrated that sulfate was the main contributor to the high concentration of PM in this study. Similar source distributions for PM10, PM2.5, and PM1 were also found, including traffic source, combustion source, secondary aerosols, industrial source, and fugitive dust, by using the positive matrix factorization (PMF) model. Furthermore, the contributions of the combustion source and secondary aerosol were found to be higher in smaller particles (PM2.5 and PM1), while the contribution of fugitive dust was higher in PM10. Moreover, dust and sand were entrained by air masses from the northwest that increased the contribution of dust in PM at the observation site. The potential source contribution function (PSCF) analysis illustrated that regional emission sources in northern and eastern Xinxiang might be important potential contributors to PM pollution in Xinxiang.
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- 2022
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168. Design of P-decorated POSS towards flame-retardant, mechanically-strong, tough and transparent epoxy resins
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Tao Wu, Feihao Yang, Jie Tao, Hai-Bo Zhao, Chuanbai Yu, and Wenhui Rao
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Biomaterials ,Colloid and Surface Chemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Published
- 2023
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169. Design and Implementation of 4WD Intelligent Car System Based on Integrated Navigation
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Jie Tao, Xin Wang, and Jiazhen Si
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Focuses on the basic principle of integrated navigation system based on geomagnetic sensor, three-axis gyroscope and three-axis accelerometer. A four-wheel independent driving car platform is designed with STM32F4 MCU as the control core and RZ7899 as the motor drive. The vehicle heading angle is obtained through the quaternion obtained by MPU6050, and combined with the geomagnetic parameters, the serial double PID control algorithm is used for navigation by correcting the deflection angle, the intelligent car can run in a straight line without other navigation systems within a certain range.
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- 2023
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170. The Gut Viral Metagenome Analysis of Domestic Dogs Captures Snapshot of Viral Diversity and Potential Risk of Coronavirus
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Ying Shi, Jie Tao, Benqiang Li, Xiaohui Shen, Jinghua Cheng, and Huili Liu
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domestic dogs ,gut virome ,viral metagenomics ,public health ,coronavirus ,Veterinary medicine ,SF600-1100 - Abstract
The close relations between dogs (Canis lupus familiaris) and humans lay a foundation for cross species transmissions of viruses. The co-existence of multiplex viruses in the host accelerate viral variations. For effective prediction and prevention of potential epidemic or even pandemic, the metagenomics method was used to investigate the gut virome status of 45 domestic healthy dogs which have extensive contact with human beings. A total of 248.6 GB data (505, 203, 006 valid reads, 150 bp in length) were generated and 325, 339 contigs, which were best matched with viral genes, were assembled from 46, 832, 838 reads. In the aggregate, 9,834 contigs (3.02%) were confirmed for viruses. The top 30 contigs with the most reads abundance were mapped to DNA virus families Circoviridae, Parvoviridae and Herpesviridae; and RNA virus families Astroviridae, Coronaviridae and Picornaviridae, respectively. Numerous sequences were assigned to animal virus families of Astroviridae, Coronaviridae, Circoviridae, etc.; and phage families of Microviridae, Siphoviridae, Ackermannviridae, Podoviridae, Myoviridae and the unclassified phages. Further, several sequences were homologous with the insect and plant viruses, which reflects the diet and habitation of dogs. Significantly, canine coronavirus was uniquely identified in all the samples with high abundance, and the phylogenetic analysis therefore showed close relationship with the human coronavirus strain 229E and NL63, indicating the potential risk of canine coronavirus to infect humans by obtaining the ability of cross-species transmission. This study emphasizes the high detection frequency of virus harbored in the enteric tract of healthy contacted animal, and expands the knowledge of the viral diversity and the spectrum for further disease-association studies, which is meaningful for elucidating the epidemiological and biological role of companion animals in public health.
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- 2021
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171. Antibiotics Attenuate Methamphetamine-Induced Hepatotoxicity by Regulating Oxidative Stress and TLR4/MyD88/Traf6 Axis
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Li-Jian Chen, Jie-Tao He, Ming Pan, Jia-Li Liu, Kai-Kai Zhang, Jia-Hao Li, Li-Bin Wang, Ling-Ling Xu, Yu-Kui Chen, Qin-Yao Zhang, Dong-Ri Li, Jing-Tao Xu, and Xiao-Li Xie
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methamphetamine ,antibiotics ,hepatotoxicity ,RNA-seq ,RT-qPCR ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Methamphetamine (METH) is a major psychostimulant drug of abuse worldwide, and its neurotoxicity has been studied extensively. In addition to neurotoxicity, METH can also induce hepatotoxicity. The underlying mechanism of intestinal microorganisms in METH-induced hepatotoxicity remains unclear. In this study, mice have received antibiotics intragastrically or PBS once each day for 1 week, followed by METH or saline. The antibiotics attenuated METH-induced hepatotoxicity as evidenced by histopathological observation and biochemical analysis; furthermore, they alleviated METH-induced oxidative stress. The effect of antibiotics on METH-induced hepatotoxicity was investigated using RNA-sequencing (RNA-seq). The RNA-seq results demonstrated that antibiotics could regulate 580 differentially expressed genes (DEGs), of which 319 were upregulated after METH treatment and then downregulated with antibiotic pretreatment and 237 were first downregulated after METH administration and then upregulated after antibiotic pretreatment, in addition to 11 upregulated and 13 downregulated ones simultaneously in METH and antibiotic-pretreated groups. RNA-seq analyses revealed that TLR4 is one of the hub genes. Western blot analysis indicated that antibiotics inhibited the increase of TLR4, MyD88 and Traf6 induced by METH. This research suggests that antibiotics may play an important role in preventing METH-induced liver injury by regulating oxidative stress and TLR4/MyD88/Traf6 axis, though further investigation is required.
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- 2021
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172. Glycosylation of β1 subunit plays a pivotal role in the toxin sensitivity and activation of BK channels
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Xiaoli Wang, Qian Xiao, Yudan Zhu, Hong Qi, Dongxiao Qu, Yu Yao, Yuxiang Jia, Jingkan Guo, Jiwei Cheng, Yonghua Ji, Guoyi Li, and Jie Tao
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BK channels ,Glycosylation ,β1-subunit ,Toxin sensitivity ,Kinetic property ,Arctic medicine. Tropical medicine ,RC955-962 ,Toxicology. Poisons ,RA1190-1270 ,Zoology ,QL1-991 - Abstract
Abstract Background: The accessory β1 subunits, regulating the pharmacological and biophysical properties of BK channels, always undergo post-translational modifications, especially glycosylation. To date, it remains elusive whether the glycosylation contributes to the regulation of BK channels by β1 subunits. Methods: Herein, we combined the electrophysiological approach with molecular mutations and biochemical manipulation to investigate the function roles of N-glycosylation in β1 subunits. Results: The results show that deglycosylation of β1 subunits through double-site mutations (β1 N80A/N142A or β1 N80Q/N142Q) could significantly increase the inhibitory potency of iberiotoxin, a specific BK channel blocker. The deglycosylated channels also have a different sensitivity to martentoxin, another BK channel modulator with some remarkable effects as reported before. On the contrary to enhancing effects of martentoxin on glycosylated BK channels under the presence of cytoplasmic Ca2+, deglycosylated channels were not affected by the toxin. However, the deglycosylated channels were surprisingly inhibited by martentoxin under the absence of cytoplasmic Ca2+, while the glycosylated channels were not inhibited under this same condition. In addition, wild type BK (α+β1) channels treated with PNGase F also showed the same trend of pharmacological results to the mutants. Similar to this modulation of glycosylation on BK channel pharmacology, the deglycosylated forms of the channels were activated at a faster speed than the glycosylated ones. However, the V1/2 and slope were not changed by the glycosylation. Conclusion: The present study reveals that glycosylation is an indispensable determinant of the modulation of β1-subunit on BK channel pharmacology and its activation. The loss of glycosylation of β1 subunits could lead to the dysfunction of BK channel, resulting in a pathological state.
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- 2021
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173. The Safety Detection for Double Tapered Roller Bearing Based on Deep Learning.
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Jie Tao, Shaobo Zhang, and Dalian Yang
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- 2018
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174. Cultivating Computational Thinking Among Students Of Liberal Art In Basic Computer Courses.
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Li Chen, Jiaoxiong Xia, and Jie Tao
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- 2018
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175. IL-6 and IL-20 as potential markers for vitality of skin contusion
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Ye, Ming-Yuan, Xu, Di, Liu, Jin-Cen, Lyu, Hao-Pin, Xue, Ye, He, Jie-Tao, Huang, Hong-Yan, Zhang, Kai-kai, Xie, Xiao-Li, and Wang, Qi
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- 2018
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176. Three resin glycosides isolated from Argyreia acuta, including two isomers
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HU, Jia-Yan, WU, Xiu-Hong, YIN, Yong-Qin, PAN, Jie-Tao, and YU, Bang-Wei
- Published
- 2018
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177. Circ-ZFR Promotes Progression of Bladder Cancer by Upregulating WNT5A Via Sponging miR-545 and miR-1270
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Liping Luo, Pingping Miao, Yao Ming, Jie Tao, and Hongchun Shen
- Subjects
circZFR ,bladder cancer ,miR-545 ,miR-1270 ,WNT5A ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
BackgroundBladder cancer is one of the most common cancers all over the world. CircZFR is a circular RNA and has been implicated in tumor generation and invasion. However, the exact role of circZFR in the development of bladder cancer (BCa) remains unknown. This study aimed to investigate the function of circZFR in BCa, and further to probe into the association between circ-ZFR, miR-545/miR-1270 and WNT5A.MethodsThe expression of circZFR in BCa was quantified by qRT-PCR and was positively correlated with the prognosis of BCa patients. Next, the stable knockdown of circZFR BCa cell lines was established and the resulting capacities of proliferation, migration and invasion were measured. The association of circZFR with miR-1270/miR-545 was predicted by circinteractome prediction, and was confirmed by luciferase assay as well as RNA pull down assay. Furthermore, miRNA inhibitors, WNT5A overexpression and Pearson correlation analysis were used to examine the relationship between circZFR, miR-1270/miR-545 and WNT5A.ResultsThe expression of CircZFR was up-regulated both in BCa tissues and in BCa cell lines, and was positively correlated with patient survival rates. Blocking of circZFR’s expression by RNA inhibitors suppressed the proliferation, migration and invasion of BCa cells both in vitro and in vivo. On the other hand, overexpression of target miRNA supported that circZFR directly interact with miR-545 and miR-1270. Moreover, we demonstrated that circZFR promotes the progression of BCa by upregulating WNT5A’s expression via sponging miR-545 and miR-1270.ConclusionsCircZFR promotes the proliferation, migration and invasion of BCa cells by upregulating WNT5A signaling pathway via sponging miR-545 and miR-1270. These results provide new insights into the molecular mechanism of circZFR in BCa progression, and more important, a novel target for BCa clinical treatment.
- Published
- 2021
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178. Synthesis and biological evaluation of cyclopeptide GG-8-6 and its analogues as anti-hepatocellular carcinoma agents
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Chen, Jie-Tao, Ma, Ru, Sun, Shi-Chang, Zhu, Xiao-Feng, Xu, Xiao-Li, and Mu, Qing
- Published
- 2018
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179. Asynchronous and Resilient Filtering for Markovian Jump Neural Networks Subject to Extended Dissipativity.
- Author
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Jie Tao, Zheng-Guang Wu, Hongye Su, Yuanqing Wu 0003, and Dan Zhang 0001
- Published
- 2019
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180. Degrees of (L, M)-fuzzy convexities.
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Yu Zhong, Fu-Gui Shi, Jie-Tao Zou, and Chu-Yi Zou
- Published
- 2019
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181. Reliable Control Against Sensor Failures for Markov Jump Systems With Unideal Measurements.
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Jie Tao, Renquan Lu, Zheng-Guang Wu, and Yuan-Qing Wu 0003
- Published
- 2019
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182. Queuing-Based Federation and Optimization for Cloud Resource Sharing
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Shuyou Wu, Zhengxiao Wu, Xiaohong Wu, Jie Tao, and Yonggen Gu
- Subjects
resource sharing ,cloud federation ,cloud computing ,game theory ,queuing model ,Information technology ,T58.5-58.64 - Abstract
Resource sharing can gain economies of scale and increase utilization of cloud infrastructure, a critical challenge of which is how to design efficient resource sharing solutions among self-interested cloud providers. Cloud federation can realize resource sharing, but the existing methods of forming federation need complex computation to guarantee the stability of federation. To address this shortcoming, after analyzing an optimal allocation approach of service requests among clouds, we propose a pareto optimal resource sharing solution named Cloud Light-Federation Sharing (CLFS), in which each cloud can choose its own optimal strategies individually and federation can be formed without complex computation for allocation of service requests and profits. In addition, an optimal resource sharing solution named Cloud Cooperative-Federation Sharing (CCFS) was also designed, in which cloud providers are fully cooperative and have fair profit allocation. The experimental results show that the two federation methods can significantly improve the total utility and decrease the number of dropped jobs. Although the federation rules of Cloud Light-Federation Sharing are simple, its performance is still very close to that of Cloud Cooperative-Federation Sharing.
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- 2022
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183. A Rolling Bearing Fault Diagnosis Method Based on Enhanced Integrated Filter Network
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Kang Wu, Jie Tao, Dalian Yang, Hu Xie, and Zhiying Li
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fault diagnosis ,enhanced integrated filter ,vector neuron ,dynamic routing ,Mechanical engineering and machinery ,TJ1-1570 - Abstract
Aiming at the difficulty of rolling bearing fault diagnosis in a strong noise environment, this paper proposes an enhanced integrated filter network. In the method, we firstly design an enhanced integrated filter, which includes the filter enhancement module and the expression enhancement module. The filter enhancement module can not only filter the high-frequency noise to extract useful features of medium and low-frequency signals but also maintain frequency and time resolution to some extent. On this basis, the expression enhancement module analyzes fault features intercepted by the upper network at multiple scales to get deep features. Then we introduce vector neurons to integrate scalar features into vector space, which mine the correlation between features. The feature vectors are transmitted by dynamic routing to establish the relationship between low-level capsules and high-level capsules. In order to verify the diagnostic performance of the model, CWRU and IMS bearing datasets are used for experimental verification. In the strong noise environment of SNR = −4 dB, the fault diagnosis precisions of the method on CWRU and IMS reach 94.85% and 92.45%, respectively. Compared with typical bearing fault diagnosis methods, the method has higher fault diagnosis precision and better generalization ability in a strong noise environment.
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- 2022
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184. Genomic Divergence Characterization and Quantitative Proteomics Exploration of Type 4 Porcine Astrovirus
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Jie Tao, Benqiang Li, Jinghua Cheng, Ying Shi, Changtao Qiao, Zhi Lin, and Huili Liu
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porcine astrovirus ,ORF2 ,genomic characterization ,divergence time ,proteomics ,Microbiology ,QR1-502 - Abstract
Porcine astrovirus (PAstV) has been identified as an important diarrheic pathogen with a broad global distribution. The PAstV is a potential pathogen to human beings and plays a role in public health. Until now, the divergence characteristics and pathogenesis of the PAstV are still not well known. In this study, the PAstV-4 strain PAstV/CH/2022/CM1 was isolated from the diarrheal feces of a piglet in Shanghai, which was identified to be a recombination of PAstV4/JPN (LC201612) and PAstV4/CHN (JX060808). A time tree based on the ORF2 protein of the astrovirus demonstrated that type 2–5 PAstV (PAstV-2 to 5) diverged from type 1 PAstV (PAstV-1) at a point from 1992 to 2000. To better understand the molecular basis of the virus, we sought to explore the host cell response to the PAstV/CH/2022/CM1 infection using proteomics. The results demonstrate that viral infection elicits global protein changes, and that the mitochondria seems to be a primary and an important target in viral infection. Importantly, there was crosstalk between autophagy and apoptosis, in which ATG7 might be the key mediator. In addition, the NOD-like receptor X1 (NLRX1) in the mitochondria was activated and participated in several important antiviral signaling pathways after the PAstV/CH/2022/CM1 infection, which was closely related to mitophagy. The NLRX1 may be a crucial protein for antagonizing a viral infection through autophagy, but this has yet to be validated. In conclusion, the data in this study provides more information for understanding the virus genomic characterization and the potential antiviral targets in a PAstV infection.
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- 2022
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185. Polarization-Insensitive Ultra-Narrow Plasmon-Induced Transparency and Short-range Surface Plasmon Polariton Bloch Wave in Ultra-thin Metallic Film Nanostructures
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Liu, Jie-Tao, Hu, Hai-Feng, and Shao, Xiao-Peng
- Published
- 2019
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186. Capsaicin receptor TRPV1 maintains quiescence of hepatic stellate cells in the liver via recruitment of SARM1
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Le Tao, Guangyue Yang, Tiantian Sun, null Jie Tao, Chan Zhu, Huimin Yu, Yalan Cheng, Zongguo Yang, Mingyi Xu, Yuefeng Jiang, Wei Zhang, Zhiyi Wang, Wenting Ma, Liu Wu, Dongying Xue, Dongxue Wang, Wentao Yang, Yongjuan Zhao, Shane Horsefield, Bostjan Kobe, Zhe Zhang, Zongxiang Tang, Qigen Li, Qiwei Zhai, Steven Dooley, Ekihiro Seki, Ping Liu, Jianrong Xu, Hongzhuan Chen, and Cheng Liu
- Subjects
Hepatology - Published
- 2023
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187. Correction to: Genome-wide development of insertiondeletion (InDel) markers for Cannabis and its uses in genetic structure analysis of Chinese germplasm and sex-linked marker identification
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Gen Pan, Zheng Li, Siqi Huang, Jie Tao, Yaliang Shi, Anguo Chen, Jianjun Li, Huijuan Tang, Li Chang, Yong Deng, Defang Li, and Lining Zhao
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Biotechnology ,TP248.13-248.65 ,Genetics ,QH426-470 - Published
- 2021
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188. Comprehensive analysis of an immune infiltrate-related competitive endogenous RNA network reveals potential prognostic biomarkers for non-small cell lung cancer.
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Cai-Zhi Yang, Lei-Hao Hu, Zhong-Yu Huang, Li Deng, Wei Guo, Shan Liu, Xi Xiao, Hong-Xing Yang, Jie-Tao Lin, Ling-Ling Sun, and Li-Zhu Lin
- Subjects
Medicine ,Science - Abstract
Globally, non-small cell lung cancer (NSCLC) is the most common malignancy and its prognosis remains poor because of the lack of reliable early diagnostic biomarkers. The competitive endogenous RNA (ceRNA) network plays an important role in the tumorigenesis and prognosis of NSCLC. Tumor immune microenvironment (TIME) is valuable for predicting the response to immunotherapy and determining the prognosis of NSCLC patients. To understand the TIME-related ceRNA network, the RNA profiling datasets from the Genotype-Tissue Expression and The Cancer Genome Atlas databases were analyzed to identify the mRNAs, microRNAs, and lncRNAs associated with the differentially expressed genes. Weighted gene co-expression network analysis revealed that the brown module of mRNAs and the turquoise module of lncRNAs were the most important. Interactions among microRNAs, lncRNAs, and mRNAs were prognosticated using miRcode, miRDB, TargetScan, miRTarBase, and starBase databases. A prognostic model consisting of 13 mRNAs was established using univariate and multivariate Cox regression analyses and validated by the receiver operating characteristic (ROC) curve. The 22 immune infiltrating cell types were analyzed using the CIBERSORT algorithm, and results showed that the high-risk score of this model was related to poor prognosis and an immunosuppressive TIME. A lncRNA-miRNA-mRNA ceRNA network that included 69 differentially expressed lncRNAs (DElncRNAs) was constructed based on the five mRNAs obtained from the prognostic model. ROC survival analysis further showed that the seven DElncRNAs had a substantial prognostic value for the overall survival (OS) in NSCLC patients; the area under the curve was 0.65. In addition, the high-risk group showed drug resistance to several chemotherapeutic and targeted drugs including cisplatin, paclitaxel, docetaxel, gemcitabine, and gefitinib. The differential expression of five mRNAs and seven lncRNAs in the ceRNA network was supported by the results of the HPA database and RT-qPCR analyses. This comprehensive analysis of a ceRNA network identified a set of biomarkers for prognosis and TIME prediction in NSCLC.
- Published
- 2021
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189. Neoadjuvant EGFR-TKI Therapy for EGFR-Mutant NSCLC: A Systematic Review and Pooled Analysis of Five Prospective Clinical Trials
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Li Sun, Yi-Jia Guo, Jun Song, Yan-Ru Wang, Shu-Ling Zhang, Le-Tian Huang, Jian-Zhu Zhao, Wei Jing, Cheng-Bo Han, and Jie-Tao Ma
- Subjects
neoadjuvant ,non-small cell lung cancer ,efficacy ,safety ,epidermal growth factor receptor-tyrosine kinase inhibitors ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
PurposeThe role of neoadjuvant epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) targeted therapy for patients with EGFR-mutant non-small cell lung cancer (NSCLC) has not been clarified. A pooled analysis of prospective clinical trials was conducted to evaluate the efficacy and safety of neoadjuvant EGFR-TKI therapy.MethodsThe PubMed, Embase, Web of Science, and Cochrane Library databases, as well as meeting abstracts were searched for prospective clinical trials evaluating the efficacy and safety of neoadjuvant EGFR-TKI for treatment of EGFR-mutant NSCLC. The main outcomes included the objective response rate (ORR), downstaging rate, surgical resection rate (SRR), pathologic complete response (pCR) rate, progression-free survival (PFS), and adverse events.ResultsA total of five, phase II, prospective, clinical trials involving 124 patients with resectable or potentially resectable EGFR-mutant NSCLC treated with neoadjuvant erlotinib or gefitinib treatment were included in this pooled analysis. The median neoadjuvant medication time was 42 (range, 21–56) days and the median time of response evaluation was 45 (range, 42–56) days. The pooled ORR was 58.5% [95% confidence interval (CI), 45.5%–71.8%] and the surgical resection and complete resection (R0) rates were 79.9% (95% CI, 65.3%–94.5%) and 64.3% (95% CI, 43.8%–84.8%), respectively. In the stage IIIA subgroup (n = 68), the pooled ORR, SRR, and R0 rate were 51.4%, 72.9%, and 57.0%, respectively, while the downstaging and pCR rates were 14.0% and 0.0%, respectively. The pooled median PFS and overall survival were 13.2 and 41.9 months, respectively. Of the most common grade 3/4 adverse events in the overall group, the incidences of hepatotoxicity and skin rash were 5.3% and 14.7%, respectively. The most commonly reported postoperative complications were lung infection, arrhythmia, and pneumothorax.ConclusionNeoadjuvant EGFR-TKI therapy provides a feasible treatment modality for patients with resectable or potentially resectable EGFR-mutant NSCLC, with satisfactory surgical outcomes and low toxicity. Although further phase III clinical trials are needed to confirm these findings, it is necessary to explore the feasibility of a more effective EGFR-TKI combination neoadjuvant therapy given the modest downgrade and pCR rates for EGFR-TKI alone.
- Published
- 2021
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190. The Complex Co-infections of Multiple Porcine Diarrhea Viruses in Local Area Based on the Luminex xTAG Multiplex Detection Method
- Author
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Ying Shi, Benqiang Li, Jie Tao, Jinghua Cheng, and Huili Liu
- Subjects
porcine viral diarrhea ,luminex xTAG multiplex detection method ,epidemiology ,co-infection ,porcine epidemic diarrhea virus ,Veterinary medicine ,SF600-1100 - Abstract
The large-scale outbreaks of severe diarrhea caused by viruses have occurred in pigs since 2010, resulting in great damage to the pig industry. However, multiple infections have contributed to the outbreak of the disease and also resulted in great difficulties in diagnosis and control of the disease. Thus, a Luminex xTAG multiplex detection method, which was more sensitive and specific than general multiplex PCR method, was developed for the detection of 11 viral diarrhea pathogens, including PKoV, PAstV, PEDV, PSaV, PSV, PTV, PDCoV, TGEV, BVDV, PoRV, and PToV. To investigate the prevalence of diarrhea-associated viruses responsible for the outbreaks, a total of 753 porcine stool specimens collected from 9 pig farms in Shanghai during 2015–2018 were tested and the pathogen spectrums and co-infections were analyzed. As a result, PKoV, PAstV and PEDV were most commonly detected viruses in diarrheal pigs with the rate of 38.65% (291/753), 20.32% (153/753), and 15.54% (117/753), respectively. Furthermore, multiple infections were commonly seen, with positive rate of 28.42%. Infection pattern of the viral diarrhea pathogens in a specific farm was changing, and different farms had the various diarrhea infection patterns. A longitudinal investigation showed that PEDV was the key pathogen which was closely related to the death of diarrhea piglets. Other pathogens might play synergistic roles in the pathogenesis of diarrhea disease. Furthermore, the surveillance confirmed that variant enteropathogenic viruses were leading etiologic agents of porcine diarrhea, either mono-infection or co-infections of PKoV were common in pigs in Shanghai, but PEDV was still the key pathogen and multiple pathogens synergistically complicated the infection status, suggesting that controlling porcine diarrhea might be more complex than previously thought. The study provides a better understanding of diarrhea viruses in piglets, which will aid in better preventing and controlling epidemics of viral porcine diarrhea.
- Published
- 2021
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191. Functional Connectivity of Nucleus Accumbens and Medial Prefrontal Cortex With Other Brain Regions During Early-Abstinence Is Associated With Alcohol Dependence and Relapse: A Resting-Functional Magnetic Resonance Imaging Study
- Author
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Xia Yang, Ya-jing Meng, Yu-jie Tao, Ren-hao Deng, Hui-yao Wang, Xiao-jing Li, Wei Wei, Yu Hua, Qiang Wang, Wei Deng, Lian-sheng Zhao, Xiao-hong Ma, Ming-li Li, Jia-jun Xu, Jing Li, Yan-song Liu, Zhen Tang, Xiang-dong Du, Jeremy W. Coid, Andrew J. Greenshaw, Tao Li, and Wan-jun Guo
- Subjects
alcohol dependence ,relapse ,relapse severity ,predictor ,rest-functional magnetic resonance imaging ,functional connectivity ,Psychiatry ,RC435-571 - Abstract
Background: Alcohol dependence (AD) is a chronic recurrent brain disease that causes a heavy disease burden worldwide, partly due to high relapse rates after detoxification. Verified biomarkers are not available for AD and its relapse, although the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) may play important roles in the mechanism of addiction. This study investigated AD- and relapse-associated functional connectivity (FC) of the NAc and mPFC with other brain regions during early abstinence.Methods: Sixty-eight hospitalized early-abstinence AD male patients and 68 age- and education-matched healthy controls (HCs) underwent resting-functional magnetic resonance imaging (r-fMRI). Using the NAc and mPFC as seeds, we calculated changes in FC between the seeds and other brain regions. Over a follow-up period of 6 months, patients were measured with the Alcohol Use Disorder Identification Test (AUDIT) scale to identify relapse outcomes (AUDIT ≥ 8).Results: Thirty-five (52.24%) of the AD patients relapsed during the follow-up period. AD displayed lower FC of the left fusiform, bilateral temporal superior and right postcentral regions with the NAc and lower FC of the right temporal inferior, bilateral temporal superior, and left cingulate anterior regions with the mPFC compared to controls. Among these FC changes, lower FC between the NAc and left fusiform, lower FC between the mPFC and left cingulate anterior cortex, and smoking status were independently associated with AD. Subjects in relapse exhibited lower FC of the right cingulate anterior cortex with NAc and of the left calcarine sulcus with mPFC compared to non-relapsed subjects; both of these reductions in FC independently predicted relapse. Additionally, FC between the mPFC and right frontal superior gyrus, as well as years of education, independently predicted relapse severity.Conclusion: This study found that values of FC between selected seeds (i.e., the NAc and the mPFC) and some other reward- and/or impulse-control-related brain regions were associated with AD and relapse; these FC values could be potential biomarkers of AD or for prediction of relapse. These findings may help to guide further research on the neurobiology of AD and other addictive disorders.
- Published
- 2021
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192. Research on the Influence of Time-Varying Excitation on Vibration Characteristics of the Spiral Bevel Geared Transmission System with Broken Teeth
- Author
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Dalian Yang, Liman Chen, Lingli Jiang, Ping Wang, and Jie Tao
- Subjects
Physics ,QC1-999 - Abstract
Due to heavy and alternating loads of working conditions, spiral bevel gears are prone to broken tooth failures. To solve the problem of vibration characteristic of spiral bevel geared transmission with broken tooth failures that is unknown, this study, considering time-varying mesh stiffness and friction excitation, proposed a torsional vibration dynamic model of spiral bevel geared transmission, which has more simple transmission path and the smaller signal attenuation. First, the time-varying excitations of various broken tooth failure are calculated and introduced into the torsional vibration dynamic model. The vibration response of spiral bevel geared transmission with various broken tooth failures is analysed in the time-frequency domain. Then, the sensitivity of the time-domain statistical index and the frequency domain components to different broken tooth failures are studied. Finally, the correctness of the simulation is verified by experiment. The results show that the crest factor is sensitive to minor tooth failure (10–30%), while kurtosis is sensitive to severe failure (30–60%). With the increase of degrees of broken tooth failure, the energy of the low-frequency band increases obviously.
- Published
- 2021
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193. BMSC-Exosomes Carry Mutant HIF-1α for Improving Angiogenesis and Osteogenesis in Critical-Sized Calvarial Defects
- Author
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Chenting Ying, Rui Wang, Zhenlin Wang, Jie Tao, Wenjing Yin, Jieyuan Zhang, Chengqing Yi, Xin Qi, and Dan Han
- Subjects
BMSC-Exos-HIF1α ,bone defects ,osteogenesis ,vascularization ,β-TCP scaffolds ,Biotechnology ,TP248.13-248.65 - Abstract
Repair and reconstruction of critical-sized bone defects has always been a difficult task in orthopedics. Hypoxia inducible factor-1α (HIF-1α) plays an important role in bone defect repair, it has the dual function of promoting osteogenesis and vascular regeneration, but it is quickly degraded by the body under normoxic conditions. Previously we prepared mutant HIF-1α, which has been shown to efficiently maintain cellular expression under normoxic conditions. In this study, we evaluated for the first time the role of exosomes of rat bone marrow mesenchymal stem cell carry mutant HIF-1α (BMSC-Exos-HIF1α) in repairing critical-sized bone defects. Evaluation of the effects of BMSC-Exos-HIF1α on bone marrow mesenchymal stem cells (BMSCs) proliferation and osteogenic differentiation by cell proliferation assay, alkaline phosphatase activity assay, alizarin red staining, real-time quantitative polymerase chain reaction. BMSC-Exos-HIF1α was loaded onto the β-TCP stent implanted in the bone defect area using a rat cranial critical-sized bone defect model, and new bone formation and neovascularization were detected in vivo by micro-CT, fluorescence labeling analysis, Microfil perfusion, histology and immunohistochemical analysis. In vitro results showed that BMSC-Exos-HIF1α stimulated the proliferation of BMSCs and up-regulated the expression level of bone-related genes, which was superior to bone marrow MSC exosomes (BMSC-Exos). In vivo results showed that BMSC-Exos-HIF1α combined with β-TCP scaffold promoted new bone regeneration and neovascularization in the bone defect area, and the effect was better than that of BMSC-Exos combined with β-TCP scaffold. In this study, the results showed that BMSC-Exos-HIF1α stimulated the proliferation and osteogenic differentiation of BMSCs and that BMSC-Exos-HIF1α combined with β-TCP scaffolds could repair critical-sized bone defects by promoting new bone regeneration and neovascularization.
- Published
- 2020
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194. Construction of a Prognostic Immune Signature for Squamous-Cell Lung Cancer to Predict Survival
- Author
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Rui-Lian Chen, Jing-Xu Zhou, Yang Cao, Ling-Ling Sun, Shan Su, Xiao-Jie Deng, Jie-Tao Lin, Zhi-Wei Xiao, Zhuang-Zhong Chen, Si-Yu Wang, and Li-Zhu Lin
- Subjects
squamous-cell lung cancer ,prognostic ,immune-related genes ,signature ,immune cells ,mutation profiles ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundLimited treatment strategies are available for squamous-cell lung cancer (SQLC) patients. Few studies have addressed whether immune-related genes (IRGs) or the tumor immune microenvironment can predict the prognosis for SQLC patients. Our study aimed to construct a signature predict prognosis for SQLC patients based on IRGs.MethodsWe constructed and validated a signature from SQLC patients in The Cancer Genome Atlas (TCGA) using bioinformatics analysis. The underlying mechanisms of the signature were also explored with immune cells and mutation profiles.ResultsA total of 464 eligible SQLC patients from TCGA dataset were enrolled and were randomly divided into the training cohort (n = 232) and the testing cohort (n = 232). Eight differentially expressed IRGs were identified and applied to construct the immune signature in the training cohort. The signature showed a significant difference in overall survival (OS) between low-risk and high-risk cohorts (P < 0.001), with an area under the curve of 0.76. The predictive capability was verified with the testing and total cohorts. Multivariate analysis revealed that the 8-IRG signature served as an independent prognostic factor for OS in SQLC patients. Naive B cells, resting memory CD4 T cells, follicular helper T cells, and M2 macrophages were found to significantly associate with OS. There was no statistical difference in terms of tumor mutational burden between the high-risk and low-risk cohorts.ConclusionOur study constructed and validated an 8-IRG signature prognostic model that predicts clinical outcomes for SQLC patients. However, this signature model needs further validation with a larger number of patients.
- Published
- 2020
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195. Composition optimization of a high-performance epoxy resin based on molecular dynamics and machine learning
- Author
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Kai Jin, Hao Luo, Ziyu Wang, Hao Wang, and Jie Tao
- Subjects
Epoxy resin ,Composition optimization ,Molecular dynamics simulation ,Machine learning ,Neural network ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Epoxy resin is a general term for a class of thermosetting polymers containing two or more epoxy groups in the molecule and has an excellent comprehensive performance. The properties of the resin system vary greatly due to the different compositions of the base resin, curing agent, and toughening agent. In this study, an optimization method for the multi-component epoxy resin system was put forward by using molecular dynamics simulations and machine learning methods. An optimized high- performance epoxy resin system considered Young's modulus (E), Ultimate Tensile Strength (UTS), Elongation (δ), and the glass transition temperature (Tg) together was designed by using the proposed method. The influence of each component proportion on mechanical properties can also be obtained automatically. It was found that 4,4′-Diaminodiphenyl Sulfone (DDS) was a better curing agent to improve Tg, E, and δ, compared with Dicyandiamide (DICY). Tetraglycidyl Diamino Diphenylmethane (TGDDM) could ensure high Tg, E and UTS, but the system still needed some Diglycidyl Ether of Bisphenol A (DGEBA) to improve toughness. The toughening agent Polyether Sulfone (PES) improved the toughness of the epoxy resin system significantly. The presented method could be extended to other resin system composition optimization.
- Published
- 2020
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196. Metastatic Breast Cancer Coexisting With HER-2 Amplification and EGFR Exon 19 Deletion Benefits From EGFR-TKI Therapy: A Case Report
- Author
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Wei Jing, Jie-Tao Ma, and Cheng-Bo Han
- Subjects
breast cancer ,lung metastasis ,EGFR mutation ,HER-2 amplification ,molecular targeted therapy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: Patients with different molecular subtypes of breast cancers have different recurrence risks and prognoses. Clinical support and evidence to guide management are absent for patients with breast cancer coexisting with HER-2 amplification and EGFR mutations.Case presentation: We report a case of breast cancer coexisting with HER-2 amplification and EGFR exon 19 deletion (E19 del). The patient presented with solitary pulmonary nodule and enlargement of hilar and mediastinal lymph nodes 2 years after radical mastectomy. Biopsy of the subcarinal lymph node showed suspected adenocarcinoma. The specimen was too small for further immunohistochemistry, but an EGFR E19 del was discovered. Due to the primary diagnosis of EGFR-mutant lung adenocarcinoma, EGFR-TKI gefitinib was administered and resulted in 1 year of stable disease until the patient developed progression in the right pulmonary nodule with new metastatic cervical lymph nodes. According to histopathological findings of re-biopsy of the pulmonary nodule and left cervical and subcarinal lymph nodes, the patient was diagnosed with breast cancer with lung metastasis and multiple lymph node metastases. The patient received multiple anti-HER-2-targeted therapies (trastuzumab for 9.7 months, lapatinib for 9 months, and pyrotinib for 4+ months) and survived for more than 36 months after lung metastasis.Conclusions: This case suggested that breast cancer coexisting with HER-2 amplification and EGFR E19 del may be driven by both HER-2 and EGFR signaling pathways, and patients can benefit from EGFR-TKI and anti-HER-2 therapy.
- Published
- 2020
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197. Hydroxypropyl-β-Cyclodextrin Complexes of Styryllactones Enhance the Anti-Tumor Effect in SW1116 Cell Line
- Author
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Ru Ma, Jie-tao Chen, Xiao-yue Ji, Xiao-li Xu, and Qing Mu
- Subjects
styryllactone ,absolute configuration ,HP-β-CD ,apoptosis ,DSC ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Styryllactones, a class of compounds obtained from the genus Goniothalamus (Annonaceae), have demonstrated in vitro antitumor activity. However, the aqueous solubility of these compounds is poor. In this study, we identified the absolute configurations of the previously isolated compounds, which were first isolated in our laboratory, by single-crystal X-ray diffraction analysis using Cu Kα radiation. Subsequently, the antitumor activities of the compounds were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide staining in four tumor cell lines. The induced apoptosis activity of leiocarpin E-7ʹ-Monoacetate was studied by an annexin V fluorescein isothiocyanate/propidium iodide double-staining experiment, and the caspase activity was tested in the SW1116 cell line. The results demonstrated that the antitumor activities of cheliensisin A and goniodiol-7-monoacetate were limited by their poor water solubility. To address this issue, hydroxypropyl-β-cyclodextrin (HP-β-CD) complexes of the compounds were synthesized by the saturated aqueous method. The complexes were then analyzed using a differential scanning calorimeter. The IC50 of cheliensisin A was reduced by 45% and 58% against SW1116 and SMMC-7721 cell lines, respectively. Similarly, the IC50 of goniodiol-7-monoacetate was reduced by 55% and 34% against the two tumor cell lines, respectively. To further evaluate whether the styryllactones and complexes possessed selectivity against cancer cell lines and normal cell lines, toxicity against human normal cell line (HEK293T) was evaluated. The results demonstrated that the HP-β-CD complexes displayed more cytotoxicity than the respective pristine compounds against the HEK293T cell line. However, there existed a therapeutic window when the complexes were applied against cancer cell lines. In summary, the synthesis of several styryllactone compounds complexed with HP-β-CD was reported for the first time. These complexes could significantly enhance the cytotoxic effects of styryllactone compounds.
- Published
- 2020
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198. Predicting the risk of sarcopenia in elderly patients with patellar fracture: development and assessment of a new predictive nomogram
- Author
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Yi-sheng Chen, Yan-xian Cai, Xue-ran Kang, Zi-hui Zhou, Xin Qi, Chen-ting Ying, Yun-peng Zhang, and Jie Tao
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Patellar fracture ,Sarcopenia ,Nomogram prediction model ,Skeletal muscle ,Logistic regression model ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Purpose To develop a risk prediction model for postoperative sarcopenia in elderly patients with patellar fractures in China. Patients and methods We conducted a community survey of patients aged ≥55 years who underwent surgery for patellar fractures between January 2013 and October 2018, through telephone interviews, community visits, and outpatient follow-up. We established a predictive model for assessing the risk of sarcopenia after patellar fractures. We developed the prediction model by combining multivariate logistic regression analysis with the least absolute shrinkage model and selection operator regression (lasso analysis) as well as the Support Vector Machine (SVM) algorithm. The predictive quality and clinical utility of the predictive model were determined using C-index, calibration plots, and decision curve analysis. We also conducted internal sampling methods for qualitative assessment. Result We recruited 137 participants (53 male; mean age, 65.7 years). Various risk factors were assessed, and low body mass index and advanced age were identified as the most important risk factor (P
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- 2020
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199. A nanoparticle-functionalized wound dressing device for toxin neutralization
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Jie Tao, Xin Xu, Haofan Liu, Xian Jiang, Jian Mao, and Maling Gou
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Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
Pore-forming toxins (PFTs) that attack host cells have shown to perform an essential role in bacterial infections. Neutralization of these toxins has become an attractive approach to promote the recovery of damaged host tissues. In this study, we propose an interconnected macroporous hydrogel containing polydiacetylene (PDA) nanoparticles to efficiently sense and bind PFTs. The PDA nanoparticles are fabricated through a self-assembly process and then mixed into the gelatin monomer solution for polymerization. Using cryogelation technology, we can obtain the nanoparticle-functionalized hydrogels with controlled interconnected pores and well-defined properties. Meanwhile, the obtained hydrogels with favorable biocompatibility show the capability of retaining the nanoparticles over a long time and efficiently binding the PFTs. In addition, the functional hydrogels with different pores present distinctive detoxification abilities. Overall, this work introduces a promising detoxification device that incorporates functional nanoparticles into the macroporous hydrogel and could be used as a wound dressing for local treatment of bacterial infections in the future. Keywords: Wound dressing device, Macroporous hydrogel, Nanoparticles, Detoxification
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- 2020
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200. Corrigendum: Kv1.3 Channel as a Key Therapeutic Target for Neuroinflammatory Diseases: State of the Art and Beyond
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Xiaoli Wang, Guoyi Li, Jingkang Guo, Zhiping Zhang, Shuzhang Zhang, Yudan Zhu, Jiwei Cheng, Lu Yu, Yonghua Ji, and Jie Tao
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Kv1.3 ,ShK ,neuroinflammatory disease ,multiple sclerosis ,stroke ,epilepsy ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Published
- 2020
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