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Activation of p53-dependent apoptosis is critical for tumor suppression but aberrant activation of p53 also leads to developmental defects and heart failure. Here, we found that Rbm24 RNA-binding protein, a target of p53, regulates p53 mRNA translation. Mechanistically, we found that through binding to p53 mRNA and interaction with translation initiation factor eIF4E, Rbm24 prevents eIF4E from binding to p53 mRNA and inhibits the assembly of translation initiation complex. Importantly, we showed that mice deficient in Rbm24 die in utero due to the endocardial cushion defect in the heart at least in part due to aberrant activation of p53-dependent apoptosis. We also showed that the heart developmental defect in Rbm24-null mice can be partially rescued by p53 deficiency through decreased apoptosis in the heart. Together, we postulate that the p53-Rbm24 loop is critical for the heart development and may be explored for mitigating congenital heart diseases and heart failure.

Task-motion planning (TMP) addresses the problem of efficiently generating executable and low-cost task plans in a discrete space such that the (initially unknown) action costs are determined by motion plans in a corresponding continuous space. However, a task-motion plan can be sensitive to unexpected domain uncertainty and changes, leading to suboptimal behaviors or execution failures. In this paper, we propose a novel framework, TMP-RL, which is an integration of TMP and reinforcement learning (RL) from the execution experience, to solve the problem of robust task-motion planning in dynamic and uncertain domains. TMP-RL features two nested planning-learning loops. In the inner TMP loop, the robot generates a low-cost, feasible task-motion plan by iteratively planning in the discrete space and updating relevant action costs evaluated by the motion planner in continuous space. In the outer loop, the plan is executed, and the robot learns from the execution experience via model-free RL, to further improve its task-motion plans. RL in the outer loop is more accurate to the current domain but also more expensive, and using less costly task and motion planning leads to a jump-start for learning in the real world. Our approach is evaluated on a mobile service robot conducting navigation tasks in an office area. Results show that TMP-RL approach significantly improves adaptability and robustness (in comparison to TMP methods) and leads to rapid convergence (in comparison to task planning (TP)-RL methods). We also show that TMP-RL can reuse learned values to smoothly adapt to new scenarios during long-term deployments.

When developing general purpose robots, the overarching software architecture can greatly affect the ease of accomplishing various tasks. Initial efforts to create unified robot systems in the 1990s led to hybrid architectures, emphasizing a hierarchy in which deliberative plans direct the use of reactive skills. However, since that time there has been significant progress in the low-level skills available to robots, including manipulation and perception, making it newly feasible to accomplish many more tasks in real-world domains. There is thus renewed optimism that robots will be able to perform a wide array of tasks while maintaining responsiveness to human operators. However, the top layer in traditional hybrid architectures, designed to achieve long-term goals, can make it difficult to react quickly to human interactions during goal-driven execution. To mitigate this difficulty, we propose a novel architecture that supports such transitions by adding a top-level reactive module which has flexible access to both reactive skills and a deliberative control module. To validate this architecture, we present a case study of its application on a domestic service robot platform., Comment: Presented at LTA AAAI-FSS, 2018

Efforts are underway at UT Austin to build autonomous robot systems that address the challenges of long-term deployments in office environments and of the more prescribed domestic service tasks of the RoboCup@Home competition. We discuss the contrasts and synergies of these efforts, highlighting how our work to build a RoboCup@Home Domestic Standard Platform League entry led us to identify an integrated software architecture that could support both projects. Further, naturalistic deployments of our office robot platform as part of the Building-Wide Intelligence project have led us to identify and research new problems in a traditional laboratory setting., Comment: Presented at AI-HRI AAAI-FSS, 2018 (arXiv:1809.06606)

This paper addresses a novel architecture for person-following robots using active search. The proposed system can be applied in real-time to general mobile robots for learning features of a human, detecting and tracking, and finally navigating towards that person. To succeed at person-following, perception, planning, and robot behavior need to be integrated properly. Toward this end, an active target searching capability, including prediction and navigation toward vantage locations for finding human targets, is proposed. The proposed capability aims at improving the robustness and efficiency for tracking and following people under dynamic conditions such as crowded environments. A multi-modal sensor information approach including fusing an RGB-D sensor and a laser scanner, is pursued to robustly track and identify human targets. Bayesian filtering for keeping track of human and a regression algorithm to predict the trajectory of people are investigated. In order to make the robot autonomous, the proposed framework relies on a behavior-tree structure. Using Toyota Human Support Robot (HSR), real-time experiments demonstrate that the proposed architecture can generate fast, efficient person-following behaviors., Comment: 7 pages, 6 figures

Robots need task planning algorithms to sequence actions toward accomplishing goals that are impossible through individual actions. Off-the-shelf task planners can be used by intelligent robotics practitioners to solve a variety of planning problems. However, many different planners exist, each with different strengths and weaknesses, and there are no general rules for which planner would be best to apply to a given problem. In this article, we empirically compare the performance of state-of-the-art planners that use either the Planning Domain Description Language (PDDL), or Answer Set Programming (ASP) as the underlying action language. PDDL is designed for task planning, and PDDL-based planners are widely used for a variety of planning problems. ASP is designed for knowledge-intensive reasoning, but can also be used for solving task planning problems. Given domain encodings that are as similar as possible, we find that PDDL-based planners perform better on problems with longer solutions, and ASP-based planners are better on tasks with a large number of objects or in which complex reasoning is required to reason about action preconditions and effects. The resulting analysis can inform selection among general purpose planning systems for particular robot task planning domains.