Search

Your search keyword '"Jalife, José"' showing total 1,040 results
Start Over Author "Jalife, José"
1,040 results on '"Jalife, José"'

151. Three-dimensional cardiac fibre disorganization as a novel parameter for ventricular arrhythmia stratification after myocardial infarction

Author

León, Daniel G, primary, López-Yunta, Mariña, additional, Alfonso-Almazán, José Manuel, additional, Marina-Breysse, Manuel, additional, Quintanilla, Jorge G, additional, Sánchez-González, Javier, additional, Galán-Arriola, Carlos, additional, Castro-Núñez, Francisco, additional, González-Ferrer, Juan José, additional, Ibáñez, Borja, additional, Pérez-Villacastín, Julián, additional, Pérez-Castellano, Nicasio, additional, Fuster, Valentín, additional, Jalife, José, additional, Vázquez, Mariano, additional, Aguado-Sierra, Jazmín, additional, and Filgueiras-Rama, David, additional

Published
2019
Full Text
View/download PDF

156. The p.P888L SAP97 polymorphism increases the transient outward current (Ito,f) and abbreviates the action potential duration and the QT interval.

Author

Tinaquero, David, Crespo-García, Teresa, Utrilla, Raquel G., Nieto-Marín, Paloma, González-Guerra, Andrés, Rubio-Alarcón, Marcos, Cámara-Checa, Anabel, Dago, María, Matamoros, Marcos, Pérez-Hernández, Marta, Tamargo, María, Cebrián, Jorge, Jalife, José, Tamargo, Juan, Bernal, Juan Antonio, Caballero, Ricardo, Delpón, Eva, ITACA Investigators, Alonso-Martín, Joaquín J., and Arribas, Fernando

Subjects
GENETIC polymorphisms, ACTION potentials, LONG QT syndrome, HEART cells, POTASSIUM channels
Abstract

Synapse-Associated Protein 97 (SAP97) is an anchoring protein that in cardiomyocytes targets to the membrane and regulates Na+ and K+ channels. Here we compared the electrophysiological effects of native (WT) and p.P888L SAP97, a common polymorphism. Currents were recorded in cardiomyocytes from mice trans-expressing human WT or p.P888L SAP97 and in Chinese hamster ovary (CHO)-transfected cells. The duration of the action potentials and the QT interval were significantly shorter in p.P888L-SAP97 than in WT-SAP97 mice. Compared to WT, p.P888L SAP97 significantly increased the charge of the Ca-independent transient outward (Ito,f) current in cardiomyocytes and the charge crossing Kv4.3 channels in CHO cells by slowing Kv4.3 inactivation kinetics. Silencing or inhibiting Ca/calmodulin kinase II (CaMKII) abolished the p.P888L-induced Kv4.3 charge increase, which was also precluded in channels (p.S550A Kv4.3) in which the CaMKII-phosphorylation is prevented. Computational protein-protein docking predicted that p.P888L SAP97 is more likely to form a complex with CaMKII than WT. The Na+ current and the current generated by Kv1.5 channels increased similarly in WT-SAP97 and p.P888L-SAP97 cardiomyocytes, while the inward rectifier current increased in WT-SAP97 but not in p.P888L-SAP97 cardiomyocytes. The p.P888L SAP97 polymorphism increases the Ito,f, a CaMKII-dependent effect that may increase the risk of arrhythmias. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

157. Brugada syndrome trafficking–defective Nav1.5 channels can trap cardiac Kir2.1/2.2 channels

Author

Pérez-Hernández, Marta, primary, Matamoros, Marcos, additional, Alfayate, Silvia, additional, Nieto-Marín, Paloma, additional, Utrilla, Raquel G., additional, Tinaquero, David, additional, de Andrés, Raquel, additional, Crespo, Teresa, additional, Ponce-Balbuena, Daniela, additional, Willis, B. Cicero, additional, Jiménez-Vazquez, Eric N., additional, Guerrero-Serna, Guadalupe, additional, da Rocha, Andre M., additional, Campbell, Katherine, additional, Herron, Todd J., additional, Díez-Guerra, F. Javier, additional, Tamargo, Juan, additional, Jalife, José, additional, Caballero, Ricardo, additional, and Delpón, Eva, additional

Published
2018
Full Text
View/download PDF

158. Implications of bipolar voltage mapping and magnetic resonance imaging resolution in biventricular scar characterization after myocardial infarction

Author

López-Yunta, Mariña, primary, León, Daniel G, additional, Alfonso-Almazán, José Manuel, additional, Marina-Breysse, Manuel, additional, Quintanilla, Jorge G, additional, Sánchez-González, Javier, additional, Galán-Arriola, Carlos, additional, Cañadas-Godoy, Victoria, additional, Enríquez-Vázquez, Daniel, additional, Torres, Carlos, additional, Ibáñez, Borja, additional, Pérez-Villacastín, Julián, additional, Pérez-Castellano, Nicasio, additional, Jalife, José, additional, Vázquez, Mariano, additional, Aguado-Sierra, Jazmín, additional, and Filgueiras-Rama, David, additional

Published
2018
Full Text
View/download PDF

160. Cardiac Kir2.1 and Na V 1.5 Channels Traffic Together to the Sarcolemma to Control Excitability

Author

Ponce-Balbuena, Daniela, primary, Guerrero-Serna, Guadalupe, additional, Valdivia, Carmen R., additional, Caballero, Ricardo, additional, Diez-Guerra, F. Javier, additional, Jiménez-Vázquez, Eric N., additional, Ramírez, Rafael J., additional, Monteiro da Rocha, André, additional, Herron, Todd J., additional, Campbell, Katherine F., additional, Willis, B. Cicero, additional, Alvarado, Francisco J., additional, Zarzoso, Manuel, additional, Kaur, Kuljeet, additional, Pérez-Hernández, Marta, additional, Matamoros, Marcos, additional, Valdivia, Héctor H., additional, Delpón, Eva, additional, and Jalife, José, additional

Published
2018
Full Text
View/download PDF

162. Genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation

Author

Nielsen, Jonas B., primary, Thorolfsdottir, Rosa B., additional, Fritsche, Lars G., additional, Zhou, Wei, additional, Skov, Morten W., additional, Graham, Sarah E., additional, Herron, Todd J., additional, McCarthy, Shane, additional, Schmidt, Ellen M., additional, Sveinbjornsson, Gardar, additional, Surakka, Ida, additional, Mathis, Michael R., additional, Yamazaki, Masatoshi, additional, Crawford, Ryan D., additional, Gabrielsen, Maiken E., additional, Skogholt, Anne Heidi, additional, Holmen, Oddgeir L., additional, Lin, Maoxuan, additional, Wolford, Brooke N., additional, Dey, Rounak, additional, Dalen, Håvard, additional, Sulem, Patrick, additional, Chung, Jonathan H., additional, Backman, Joshua D., additional, Arnar, David O., additional, Thorsteinsdottir, Unnur, additional, Baras, Aris, additional, O’Dushlaine, Colm, additional, Holst, Anders G., additional, Wen, Xiaoquan, additional, Hornsby, Whitney, additional, Dewey, Frederick E., additional, Boehnke, Michael, additional, Kheterpal, Sachin, additional, Lee, Seunggeun, additional, Kang, Hyun M., additional, Holm, Hilma, additional, Kitzman, Jacob, additional, Shavit, Jordan A., additional, Jalife, José, additional, Brummett, Chad M., additional, Teslovich, Tanya M., additional, Carey, David J., additional, Gudbjartsson, Daniel F., additional, Stefansson, Kari, additional, Abecasis, Goncalo R., additional, Hveem, Kristian, additional, and Willer, Cristen J., additional

Published
2018
Full Text
View/download PDF

163. Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development

Author

Nielsen, Jonas B., primary, Fritsche, Lars G., additional, Zhou, Wei, additional, Teslovich, Tanya M., additional, Holmen, Oddgeir L., additional, Gustafsson, Stefan, additional, Gabrielsen, Maiken E., additional, Schmidt, Ellen M., additional, Beaumont, Robin, additional, Wolford, Brooke N., additional, Lin, Maoxuan, additional, Brummett, Chad M., additional, Preuss, Michael H., additional, Refsgaard, Lena, additional, Bottinger, Erwin P., additional, Graham, Sarah E., additional, Surakka, Ida, additional, Chu, Yunhan, additional, Skogholt, Anne Heidi, additional, Dalen, Håvard, additional, Boyle, Alan P., additional, Oral, Hakan, additional, Herron, Todd J., additional, Kitzman, Jacob, additional, Jalife, José, additional, Svendsen, Jesper H., additional, Olesen, Morten S., additional, Njølstad, Inger, additional, Løchen, Maja-Lisa, additional, Baras, Aris, additional, Gottesman, Omri, additional, Marcketta, Anthony, additional, O’Dushlaine, Colm, additional, Ritchie, Marylyn D., additional, Wilsgaard, Tom, additional, Loos, Ruth J.F., additional, Frayling, Timothy M., additional, Boehnke, Michael, additional, Ingelsson, Erik, additional, Carey, David J., additional, Dewey, Frederick E., additional, Kang, Hyun M., additional, Abecasis, Gonçalo R., additional, Hveem, Kristian, additional, and Willer, Cristen J., additional

Published
2018
Full Text
View/download PDF

174. Complement Destabilizes Cardiomyocyte Function in Vivo after Polymicrobial Sepsis and In Vitro 2

Author

Kalbitz, Miriam, Fattahi, Fatemeh, Herron, Todd J., Grailer, Jamison J., Jajou, Lawrence, Lu, Hope, Huber-Lang, Markus, Zetoune, Firas S., Sarma, J. Vidya, Day, Sharlene M., Russell, Mark W., Jalife, José, and Ward, Peter A.

Subjects
Cytoplasm, Mice, Calcium Channels, L-Type, Coinfection, Sepsis, Animals, Calcium, Complement C5a, Heart, Myocytes, Cardiac, Receptor, Anaphylatoxin C5a, Article, Sarcoplasmic Reticulum Calcium-Transporting ATPases
Abstract

There is accumulating evidence during sepsis that cardiomyocyte (CM) homeostasis is compromised, resulting in cardiac dysfunction. An important role for complement in these outcomes is now demonstrated. Addition of C5a to electrically paced CMs caused prolonged elevations of intracellular Ca(2+) concentrations during diastole, together with the appearance of spontaneous Ca(2+) transients. In polymicrobial sepsis in mice, we found that three key homeostasis-regulating proteins in CMs were reduced: Na(+)/K(+)-ATPase, which is vital for effective action potentials in CMs, and two intracellular Ca(2+) concentration regulatory proteins, that is, sarcoplasmic/endoplasmic reticulum calcium ATPase 2 and the Na(+)/Ca(2+) exchanger. Sepsis caused reduced mRNA levels and reductions in protein concentrations in CMs for all three proteins. The absence of either C5a receptor mitigated sepsis-induced reductions in the three regulatory proteins. Absence of either C5a receptor (C5aR1 or C5aR2) diminished development of defective systolic and diastolic echocardiographic/Doppler parameters developing in the heart (cardiac output, left ventricular stroke volume, isovolumic relaxation, E' septal annulus, E/E' septal annulus, left ventricular diastolic volume). We also found in CMs from septic mice the presence of defective current densities for Ik1, l-type calcium channel, and Na(+)/Ca(2+) exchanger. These defects were accentuated in the copresence of C5a. These data suggest complement-related mechanisms responsible for development of cardiac dysfunction during sepsis.

Published
2016

178. Scn2b Deletion in Mice Results in Ventricular and Atrial Arrhythmias

Author

Bao, Yangyang, primary, Willis, B. Cicero, additional, Frasier, Chad R., additional, Lopez-Santiago, Luis F., additional, Lin, Xianming, additional, Ramos-Mondragón, Roberto, additional, Auerbach, David S., additional, Chen, Chunling, additional, Wang, Zhenxun, additional, Anumonwo, Justus, additional, Valdivia, Héctor H., additional, Delmar, Mario, additional, Jalife, José, additional, and Isom, Lori L., additional

Published
2016
Full Text
View/download PDF

179. Reply

Author

Takemoto, Yoshio, primary, Kaur, Kuljeet, additional, Oral, Hakan, additional, and Jalife, José, additional

Published
2016
Full Text
View/download PDF

180. Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors.

Author

Jianhua Zhang, Ran Tao, Campbell, Katherine F., Carvalho, Juliana L., Ruiz, Edward C., Kim, Gina C., Schmuck, Eric G., Raval, Amish N., da Rocha, André Monteiro, Herron, Todd J., Jalife, José, Thomson, James A., and Kamp, Timothy J.

Abstract

Cardiac fibroblasts (CFs) play critical roles in heart development, homeostasis, and disease. The limited availability of human CFs from native heart impedes investigations of CF biology and their role in disease. Human pluripotent stem cells (hPSCs) provide a highly renewable and genetically defined cell source, but efficient methods to generate CFs from hPSCs have not been described. Here, we show differentiation of hPSCs using sequential modulation of Wnt and FGF signaling to generate second heart field progenitors that efficiently give rise to hPSC-CFs. The hPSC-CFs resemble native heart CFs in cell morphology, proliferation, gene expression, fibroblast marker expression, production of extracellular matrix and myofibroblast transformation induced by TGFβ1 and angiotensin II. Furthermore, hPSC-CFs exhibit a more embryonic phenotype when compared to fetal and adult primary human CFs. Co-culture of hPSC-CFs with hPSC-derived cardiomyocytes distinctly alters the electrophysiological properties of the cardiomyocytes compared to co-culture with dermal fibroblasts. The hPSC-CFs provide a powerful cell source for research, drug discovery, precision medicine, and therapeutic applications in cardiac regeneration. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

181. Implications of bipolar voltage mapping and magnetic resonance imaging resolution in biventricular scar characterization after myocardial infarction.

Author

López-Yunta, Mariña, León, Daniel G, Alfonso-Almazán, José Manuel, Marina-Breysse, Manuel, Quintanilla, Jorge G, Sánchez-González, Javier, Galán-Arriola, Carlos, Cañadas-Godoy, Victoria, Enríquez-Vázquez, Daniel, Torres, Carlos, Ibáñez, Borja, Pérez-Villacastín, Julián, Pérez-Castellano, Nicasio, Jalife, José, Vázquez, Mariano, Aguado-Sierra, Jazmín, and Filgueiras-Rama, David

Abstract

Aims: We aimed to study the differences in biventricular scar characterization using bipolar voltage mapping compared with state-of-the-art in vivo delayed gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) imaging and ex vivo T1 mapping.Methods and Results: Ten pigs with established myocardial infarction (MI) underwent in vivo scar characterization using LGE-CMR imaging and high-density voltage mapping of both ventricles using a 3.5-mm tip catheter. Ex vivo post-contrast T1 mapping provided a high-resolution reference. Voltage maps were registered onto the left and right ventricular (LV and RV) endocardium, and epicardium of CMR-based geometries to compare voltage-derived scars with surface-projected 3D scars. Voltage-derived scar tissue of the LV endocardium and the epicardium resembled surface projections of 3D in vivo and ex vivo CMR-derived scars using 1-mm of surface projection distance. The thinner wall of the RV was especially sensitive to lower resolution in vivo LGE-CMR images, in which differences between normalized low bipolar voltage areas and CMR-derived scar areas did not decrease below a median of 8.84% [interquartile range (IQR) (3.58, 12.70%)]. Overall, voltage-derived scars and surface scar projections from in vivo LGE-CMR sequences showed larger normalized scar areas than high-resolution ex vivo images [12.87% (4.59, 27.15%), 18.51% (11.25, 24.61%), and 9.30% (3.84, 19.59%), respectively], despite having used optimized surface projection distances. Importantly, 43.02% (36.54, 48.72%) of voltage-derived scar areas from the LV endocardium were classified as non-enhanced healthy myocardium using ex vivo CMR imaging.Conclusion: In vivo LGE-CMR sequences and high-density voltage mapping using a conventional linear catheter fail to provide accurate characterization of post-MI scar, limiting the specificity of voltage-based strategies and imaging-guided procedures. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

185. Complement Destabilizes Cardiomyocyte Function In Vivo after Polymicrobial Sepsis and In Vitro

Author

Kalbitz, Miriam, primary, Fattahi, Fatemeh, additional, Herron, Todd J., additional, Grailer, Jamison J., additional, Jajou, Lawrence, additional, Lu, Hope, additional, Huber-Lang, Markus, additional, Zetoune, Firas S., additional, Sarma, J. Vidya, additional, Day, Sharlene M., additional, Russell, Mark W., additional, Jalife, José, additional, and Ward, Peter A., additional

Published
2016
Full Text
View/download PDF

187. Constitutive Intracellular Na + Excess in Purkinje Cells Promotes Arrhythmogenesis at Lower Levels of Stress Than Ventricular Myocytes From Mice With Catecholaminergic Polymorphic Ventricular Tachycardia

Author

Willis, B. Cicero, primary, Pandit, Sandeep V., additional, Ponce-Balbuena, Daniela, additional, Zarzoso, Manuel, additional, Guerrero-Serna, Guadalupe, additional, Limbu, Bijay, additional, Deo, Makarand, additional, Camors, Emmanuel, additional, Ramirez, Rafael J., additional, Mironov, Sergey, additional, Herron, Todd J., additional, Valdivia, Héctor H., additional, and Jalife, José, additional

Published
2016
Full Text
View/download PDF

190. Extracellular Matrix–Mediated Maturation of Human Pluripotent Stem Cell–Derived Cardiac Monolayer Structure and Electrophysiological Function

Author

Herron, Todd J., primary, Rocha, Andre Monteiro Da, additional, Campbell, Katherine F., additional, Ponce-Balbuena, Daniela, additional, Willis, B. Cicero, additional, Guerrero-Serna, Guadalupe, additional, Liu, Qinghua, additional, Klos, Matt, additional, Musa, Hassan, additional, Zarzoso, Manuel, additional, Bizy, Alexandra, additional, Furness, Jamie, additional, Anumonwo, Justus, additional, Mironov, Sergey, additional, and Jalife, José, additional

Published
2016
Full Text
View/download PDF

191. Nav1.5 N-terminal domain binding to α1-syntrophin increases membrane density of human Kir2.1, Kir2.2 and Nav1.5 channels

Author

Matamoros, Marcos, primary, Pérez-Hernández, Marta, additional, Guerrero-Serna, Guadalupe, additional, Amorós, Irene, additional, Barana, Adriana, additional, Núñez, Mercedes, additional, Ponce-Balbuena, Daniela, additional, Sacristán, Sandra, additional, Gómez, Ricardo, additional, Tamargo, Juan, additional, Caballero, Ricardo, additional, Jalife, José, additional, and Delpón, Eva, additional

Published
2016
Full Text
View/download PDF

193. Abstract 11513: Eplerenone Treatment Mitigates Atrial Structural Remodeling but Does Not Modify the Transition From Paroxysmal to Persistent Atrial Fibrillation in an Ovine Model

Author

Takemoto, Yoshio, primary, Ramirez, Rafael J, additional, Kaur, Kuljeet, additional, Ponce-Balbuena, Daniela, additional, Ramos-Mondragon, Roberto, additional, Willis, Byrd C, additional, Ennis, Steven R, additional, Guerrero-Serna, Guadalupe, additional, Pandit, Sandeep V, additional, Berenfeld, Omer, additional, and Jalife, José, additional

Published
2015
Full Text
View/download PDF

195. Inheritable Potassium Channel Disease

Author

Amin, Ahmad S., Wilde, Arthur A. M., Zipes, Douglas P., Jalife, José, Cardiology, and Amsterdam Cardiovascular Sciences

Published
2013

197. PRINCIPIOS BÁSICOS DE LAS NUEVAS ESTRATEGIAS FARMACOLÓGICAS ANTIARRíTMICAS EN FIBRILACIÓN AURICULAR

Author

Filgueiras-Rama,David, Castrejón,Sergio, Calvo,Conrado, Estrada,Alejandro, Doiny,David, Ortega,Marta, Berenfeld,Omer, Merino,José L, and Jalife,José

Subjects
Dronedarona, España, Heart, Fibrilación auricular, Rotores, Article, Electrophysiological Phenomena, Rotors, Fármacos antiarrítmicos, Atrial Fibrillation, Humans, Corrientes iónicas, Remodelado auricular, Anti-Arrhythmia Agents
Abstract

La fibrilación auricular (FA) es la arritmia crónica sostenida más frecuente en la población general. A pesar de los últimos avances tecnológicos y en el entendimiento de sus mecanismos, derivados de modelos experimentales, así como de los procedimientos de ablación en pacientes con FA, los fármacos antiarrítmicos siguen siendo la principal estrategia para la cardioversión y mantenimiento del ritmo sinusal. Nuevas generaciones de fármacos antiarrítmicos han llegado a la práctica clínica, y otros se encuentran en fase de experimentación. Los nuevos fármacos actúan de forma más específica sobre corrientes iónicas auriculares, y al mismo tiempo involucradas en el mantenimiento de la arritmia. Paralelamente, cada vez se da más importancia a la necesidad de actuar sobre el sustrato arritmogénico auricular y los factores que lo promueven, implicados en el mantenimiento a largo plazo de la arritmia (terapias upstream). La presente revisión tiene como objetivo exponer las actuales líneas de desarrollo en fármacos antiarrítmicos y terapias para prevención o retraso del remodelado auricular, con base a los conocimientos mecanísticos que hoy en día se involucran en el mantenimiento de la FA.

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results