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151. CARACTERIZAÇÃO FÍSICA E QUÍMICA DE MISTURAS CIMENTÍCIAS COM INCORPORAÇÃO DE BAGAÇO DE AZEITONA

Author: J Teixeira, A Jerónimo, M Fernandes, and A Briga-Sá
Published: 2022
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152. Association between age and muscle function, architecture, and composition in long-distance master runners: a cross-sectional study

Author: J. Teixeira, A.G. Brauer Júnior, A.E. Lima-Silva, and P.C.B. Bento
Subjects: Male, Endurance runners, Aging, Musculoskeletal system, Knee Joint, Physiology, General Neuroscience, Immunology, Biophysics, Master athletes, Ocean Engineering, Cell Biology, General Medicine, Middle Aged, Biochemistry, Master runners, Quadriceps Muscle, Cross-Sectional Studies, Torque, Humans, Knee, Muscle Strength, General Pharmacology, Toxicology and Pharmaceutics, Muscle, Skeletal
Abstract: The aim of this study was to describe the muscle function, architecture, and composition of long-distance master runners, and verify the association between age and these variables. Additionally, different clusters of runners were compared based on age and training variables. Forty male runners (≥50 years) reported their training routine and had their muscle function evaluated through maximum knee extensor isometric peak torque (PT) assessed with an isokinetic dynamometer. The cross-sectional area (CSA), pennation angle (PA), fascicle length (FL), muscle thickness (MT), and echo intensity (EI) were evaluated through ultrasound (muscle architecture and composition). The participants were 58.7±6.2 years old and had been training for 18.4±10.3 years, 4 sessions/week with 298.8±164.7 min/week of training. The absolute torque was 226.92±63.44 N·m, and the specific torque (PT/CSA) was 7.29±3.78 N·m/cm2. Regarding muscle architecture, the phase angle was 17.34±4°, the fascicle angle 6.78±1.04 cm, muscle thickness 2.93±0.56 cm, and the cross-sectional area 21.24±5.88 cm2. Concerning muscle composition, the master runners showed echo intensity values of 62.05±11.68 AU. The analysis demonstrated a weak and negative association between age and some muscle architecture variables (CSA and MT) and muscle function (PT). No association was verified between age and muscle composition (EI). Age partially explained CSA, MT, and muscle function changes (13, 11, and 14%, respectively). Participants' high level of physical training might have contributed to the low association between these variables and the lack of association with muscle composition.
Published: 2022

153. Assement of the Turbulent Blood Flow Hemodynamics in a Real Stenotic Geometry with Rans and Les Models

Author: Diogo Lopes, R. Agujetas, H. Puga, J. Teixeira, R. Lima, J. Grilo, and C. Ferrera
Published: 2022
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154. Reliability and Validity of UNESP-Botucatu Cattle Pain Scale and Cow Pain Scale in Bos taurus and Bos indicus Bulls to Assess Postoperative Pain of Surgical Orchiectomy

Author: Rubia M. Tomacheuski, Alice R. Oliveira, Pedro H. E. Trindade, Flávia A. Oliveira, César P. Candido, Francisco J. Teixeira Neto, Paulo V. Steagall, and Stelio P. L. Luna
Subjects: domestic cows, General Veterinary, animal behaviour, pain assessment, Animal Science and Zoology, farm animals, pain measurement, animal welfare
Abstract: Pain assessment guides decision-making in pain management and improves animal welfare. We aimed to investigate the reliability and validity of the UNESP-Botucatu cattle pain scale (UCAPS) and the cow pain scale (CPS) for postoperative pain assessment in Bos taurus (Angus) and Bos indicus (Nelore) bulls after castration. Methods: Ten Nelore and nine Angus bulls were anaesthetised with xylazine–ketamine–diazepam–isoflurane–flunixin meglumine. Three-minute videos were recorded at -48 h, preoperative, after surgery, after rescue analgesia and at 24 h. Two evaluators assessed 95 randomised videos twice one month apart. Results: There were no significant differences in the pain scores between breeds. Intra and inter-rater reliability varied from good (>0.70) to very good (>0.81) for all scales. The criterion validity showed a strong correlation (0.76–0.78) between the numerical rating scale and VAS versus UCAPS and CPS, and between UCAPS and CPS (0.76). The UCAPS and CPS were responsive; all items and total scores increased after surgery. Both scales were specific (81–85%) and sensitive (82–87%). The cut-off point for rescue analgesia was >4 for UCAPS and >3 for CPS. Conclusions. The UCAPS and CPS are valid and reliable to assess postoperative pain in Bos taurus and Bos indicus bulls.
Published: 2023
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155. Using a linear inverse heat conduction model to estimate the boundary heat flux with a material undergoing phase transformation

Author: A.V.S. Oliveira, J. Teixeira, V. Schick, D. Maréchal, M. Gradeck, and S. Denis
Subjects: Energy Engineering and Power Technology, Industrial and Manufacturing Engineering
Published: 2023
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156. The impact of injury on match running performance following the return to competitive match-play over two consecutive seasons in elite European soccer players.

Author: R., MORGANS, D., RHODES, E., BEZUGLOV, O., ETEMAD, R., DI MICHELE, J., TEIXEIRA, T., MODRIC, S., VERSIC, and R., OLIVEIRA
Abstract: Based on the assessment and diagnosis, the rest period following a moderate/severe injury may lead to deconditioning for the injured player and therefore an association with a prolonged rehabilitation, re-conditioning and return to sport is observed post-injury. The aim of the present study was to assess the impact of all injuries on match running performance following the return to competitive match-play over two consecutive seasons in elite European soccer players. A retrospective analysis was conducted utilizing data related to a player's injury and match running performance. A club physiotherapist consistently recorded availability and injury data in a standardized format. Linear mixed modelling analysis revealed no difference between PRE and POST1, POST2, and POST3 for total distance, running distance, high-intensity distance, and sprint distance (all p >0.05). Although, maximum speed was significantly (p<0.05) lower in POST1 and POST2 when compared to PRE, in both cases with a large (ES = 1.88) effect. No significant difference was observed for maximum speed between PRE and POST3 (p=0.07). There were very low correlations between the number of days absent and changes in maximum speed between POST1 and PRE (r = 0.09, 95% CI -0.42 to 0.56), and POST2 and PRE (r = 0.10, 95% CI -0.42 to 0.57), respectively. In conclusion, no variation in distance variables were found regardless of one, two or three matches post-injury compared to pre-injury status. Moreover, maximum speed was lower during the first three matches post-injury, although the mean value was slightly lower. Finally, a low correlation between absent days and maximum speed loss between pre-injury and following one and two matches were found. [ABSTRACT FROM AUTHOR]
Published: 2023
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157. P-171 Prognostic value of conversion from RAS-mutated to RAS wild-type during treatment of metastatic colorectal cancer using liquid biopsies – real-world data of two Portuguese institutions

Author: J. Albuquerque, D. Neto da Silva, T. Padrão, L. Leal da Costa, R. Bizarro, J. Correia, C. Baptista, M. Machete, G. Prazeres, I. Margarido, G. Fernandes, P. Simões, T. Timóteo, F. Lopes, J. Godinho, J. Moreira-Pinto, T. Rodrigues, A. Faria, C. Pulido, L. Cirnes, J. Teixeira, and J. Passos-Coelho
Subjects: Oncology, Hematology
Published: 2022
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158. Alcohol-induced psychotic disorder: a study of hospitalized patients in Lisbon

Author: V. Nogueira, I. Pereira, M. Moreno, and J. Teixeira
Subjects: Psychiatry and Mental health
Abstract: Introduction While alcohol-induced psychotic disorder (AIPD) is a well-recognised clinical disorder, relativery little is known about aspects such as epidemiology, course and treatment of the condition. Current evidence suggests AIPD can be clinically distinguised from alcohol-withdrawal delirium and schizophrenia. AIPD is associated with high comorbidity with other psychiatric disorders, high re-hospitalization and mortality rate, namely suicidal behaviour. Objectives The objetive of the study was to examine the correlates, clinical features, psycopathology, and short-term response in an inpatient sample with alcohol-induced psychotic disorder, predominant hallucinations (ICD-10 F10.52) admitted to Centro Hospitalar Psiquiátrico de Lisboa. Methods We collected retrospectively data from all admitted patients to our Alcohol Unit between January 2010 and January 2020 with the diagnosis of AIPD. The exclusion criteria were: presence of preexisting psychotic disorder, delirium, or other substance use disorders. We characterized our sample in Demographic categories, Clinical categories, Treatment and Short-term course. Results A total of 113 subjects were included in the study. The prevalance of alcoholic hallucinosis was found to be 1.3% of all patients who received inpatient treatment. Most individuals reported auditory hallucinations, that iniciated when they decrease their alcohol intake, and 1 in 4 had past episodes of AIPD. Conclusions There are specific challenges in studiyng AIPD, such as the relatively rarity of the disorder, its often transient nature and high levels of comorbidity. A high degree of recurrence and morbidity indicates a need to prevent, and intervene early with an abstinent-oriented management goal. Disclosure No significant relationships.
Published: 2022
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159. Percutaneous radiofrequency rhizotomy and neurovascular decompression of the trigeminal nerve for the treatment of facial pain Rizotomia percutânea por radiofreqüência e a descompressão neurovascular do nervo trigêmeo no tratamento das algias faciais

Author: Manoel J. Teixeira, Silvia R.D.T. Siqueira, and Gilberto M. Almeida
Subjects: dor facial, neurocirurgia funcional, neuralgia trigeminal, rizotomia por radiofreqüência, descompressão neurovascular, facial pain, neurosurgery, trigeminal neuralgia, radiofrequency rhizotomy, vascular decompression, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: OBJECTIVE: To determine the outcomes of 354 radiofrequency rhizotomies and 21 neurovascular decompressions performed as treatment for 367 facial pain patients (290 idiopathic trigeminal neuralgia, 52 symptomatic trigeminal neuralgia, 16 atypical facial pain, 9 post-herpetic neuralgia). METHOD: Clinical findings and surgery success rate were considered for evaluation. A scale of success rate was determined to classify patients, which considered pain relief and functional/sensorial deficits. RESULTS: Radiofrequency rhizotomy was performed in 273 patients with idiopathic trigeminal neuralgia and in all other patients, except for trigeminal neuropathy; neurovascular decompression was performed in 18 idiopathic trigeminal neuralgia patients; 100% idiopathic trigeminal neuralgia, 96.2% symptomatic trigeminal neuralgia, 37.5% atypical facial pain and 88.9% post-herpetic neuralgia had pain relief. CONCLUSION: Both techniques for idiopathic trigeminal neuralgia are usefull. Radiofrequency rhizotomy was also efficient to treat symptomatic facial pain, and post-herpetic facial pain, but is not a good technique for atypical facial pain.OBJETIVO: Determinar eficácia e achados pós-operatórios após 354 rizotomias por radiofreqüência e 21 descompressões neurovasculares como tratamento de 367 pacientes com dor facial (290 neuralgia idiopática do trigêmeo, 52 neuralgia sintomática do trigêmeo, 16 dor facial atípica, 9 neuralgia pós-herpética). MÉTODO: Achados clínicos e taxa de sucesso das cirurgias foram considerados para a avaliação. Uma escala avaliando alívio da dor e complicações sensoriais e funcionais foi utilizada para classificar os pacientes. RESULTADOS: A rizotomia por radiofreqüência foi realizada em 273 pacientes com neuralgia idiopática do trigêmeo e em todos os outros pacientes, exceto neuropatia trigeminal; descompressão neurovascular foi realizada em 18 pacientes com neuralgia idiopática do trigêmeo; 100% dos pacientes com neuralgia idiopática do trigêmeo, 96.2% dos pacientes com neuralgia sintomática, 37.5% dos pacientes com dor facial atípica e 88.9% dos doentes com neuralgia pós-herpética tiveram alívio da dor. CONCLUSÃO: Ambas as técnicas são úteis para a neuralgia idiopática do trigêmeo. A rizotomia por radiofreqüência foi também eficiente para tratar neuralgia sintomática do trigêmeo e pós-herpética, mas não foi uma boa técnica como tratamento da dor facial atípica.
Published: 2006
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160. SUNCT syndrome associated with pituitary tumor: case report Síndrome SUNCT associada a tumor de hipófise: relato de caso

Author: Pedro A.S. Rocha Filho, Antonio Cezar R. Galvão, Manoel J. Teixeira, Getulio D. Rabello, Ida Fortini, Marcelo Calderaro, and Dalva Carrocini
Subjects: SUNCT, tumor de hipófise, cirurgia, cefaléia de curta duração, pituitary tumor, surgery, ultra- shorting headaches, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: For twelve years, the subject of this report, a 38-year-old man, presented a clinical condition compatible with the SUNCT (short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing) syndrome. He presented a stabbing and intense daily pain located in the left pre-auricular and temporal regions. Each of these intense pain attacks lasted around one minute and presented a frequency of two to eight times per day. The pain was associated with ipsilateral lacrimation, conjunctival injection and rhinorrhea. MRI revealed a pituitary tumor with little suprasellar extent. The subject’s serial assays of prolactin, GH, TSH and ACTH were within normal levels. Following transsphenoidal hypophysectomy, with complete removal of the tumor, the subject no more presented pain. The pathological diagnosis was non-secreting adenoma. Fourteen months after the surgery, he remains symptom-free.O paciente relatado neste artigo apresentou uma condição clínica compatível com síndrome SUNCT (cefaléia de curta duração, unilateral, neuralgiforme com hiperemia conjuntival e lacrimejamento). Ele referia dor diária, intensa, em facada, localizada na região pré-auricular e temporal esquerdas. Cada ataque de dor permanecia por cerca de um minuto, com freqüência de duas a oito vezes por dia. A dor se acompanhava de lacrimejamento ipsolateral, congestão conjuntival e rinorréia. A RM mostrou um tumor de hipófise com pouca extensão suprasselar. Dosagens de prolactina, GH, TSH e ACTH estavam em níveis normais. Foi então submetido a hipofisectomia transesfenoidal com remoção completa do tumor após o que a dor cessou completamente. O diagnóstico anátomo-patológico foi adenoma não secretor. Quatorze meses após a cirurgia, o paciente permanecia livre de dor.
Published: 2006
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161. Strictly Non-Blocking All-Optical-Cross-Connect Demonstrator for WDM Wavelength Path Networks.

Author: Paulo S. André, João L. Pinto, António L. J. Teixeira, Armando Nolasco Pinto, Teresa Almeida, Fernando Morgado, and M. Pousa
Published: 2002
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162. Solder Paste Additives for Thermal Expansion Control

Author: P. Capela, M. S. Souza, S. Costa, M. Fernandes, H. Figueiredo, R. Alves, I. Delgado, J. Teixeira, and D. Soares
Abstract: Most electronic failures that occur in equipment are due to stresses induced by differences in the Coefficient of Thermal Expansion (CTE) of the different materials in a Printed Circuit Board Assemblies (PCBA). During a thermal cycle, the incompatibility of CTE between the PCB and the components induces shear fatigue that may affect the reliability of the solder interconnections on the PCB, which can eventually lead to fracture and failure of the joints and the PCB. Due to the advancement in the electronic components industry, interest from the researcher’s point of view has grown in studying the influence of additives in the solder alloys, in relation to microstructure, physical and mechanical properties and, mainly in the CTE. In this work two types of additives (Bi and graphite powder) were tested in order to reduce the CTE of a lead-free solder (SAC305) solder paste for reflow soldering. Because the selected additives have different characteristics, namely different densities, a different method of SAC305 solder additivation was tested for each type of additive. For Bi addition in SAC305 alloy (up to 6.5 wt.%), after a mechanical mixing of it, with the solder paste, a fusion technique (with a thermal cycle similar to the used on the reflow soldering) was used. For composites with graphite (addition up to 0.1 wt.%) a double-printing method was used in order to achieve a homogeneous additive distribution, so that graphite remained in the final ingot. These additivated solder alloys were chemically analyzed and characterized for thermogravimetric properties. Samples microstructure were characterized by SEM/EDS analysis, and also they were tested for their electrical resistivity. With graphite addition there is a slight increase on the initial alloy melting temperature (∼1.5°C) and with Bi an almost linear decrease was obtained (∼16 °C for the higher tested Bi addition). Composites with bismuth have a decrease trend, with the additive increase content until close to 5%. The CTE value decreases almost linearly ((from 25 to ∼14.5 μm/(m·°C); R2 = 0.9905). However, the sample of SAC305 + 6.5% Bi does not follow this trend, which may indicate that for these and higher amounts of bismuth, the composite CTE stabilizes. For composites with graphite there is a reduction of CTE (from 25 to ∼17 μm/(m·°C) for 0.04 wt. % graphite addition). For higher graphite additions the CTE seems to increase. The obtained results show that both additives can be used in order to achieve a CTE target value close to the PCB copper PAD (17 μm/(m·°C). However, the mixing method used for graphite mixing on solder paste cannot be directly transposed to the reflow soldering technique.
Published: 2021
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163. The effects of phosphatidic acid on performance and body composition - a scoping review

Author: Filipe J. Teixeira, Stuart M. Phillips, Nelson Tavares, and Catarina N Matias
Subjects: Muscle protein, Adult, Male, Adult male, Anabolism, business.industry, Physiology, Muscle Proteins, Phosphatidic Acids, Physical Therapy, Sports Therapy and Rehabilitation, Phosphatidic acid, Sports nutrition, chemistry.chemical_compound, chemistry, Dietary Supplements, Lean body mass, Body Composition, Medicine, Humans, Orthopedics and Sports Medicine, Composition (visual arts), business, Direct stimulation, Aged
Abstract: Phosphatidic acid (PA) is a lipid mediator proposed to increase muscle protein synthesis via direct stimulation of the mammalian target of rapamycin (mTOR) and may act as an anabolic supplemental aid. Evidence on the effectiveness of PA as an anabolic supplement is equivocal. We aimed to systematically assess the effect of PA on performance and body composition. Due to the small number of studies, this is a scoping review. A comprehensive search was performed in Pubmed, SPORTDiscus and Web of Science, from the 1 January 2010 to the 31 August 2020. Our search retrieved 2009 articles, which when filtered, resulted in six studies, published between 2012 and 2019, which were analysed further. Five studies were performed in adult male populations and one in an elderly male population. From these, three studies suggested no effect of PA on lean body mass , while the remaining showed a possible positive effect (body composition and performance improvements). In one of these, the supplement included other potentially anabolic substances, precluding an isolated effect of PA. After a thorough analysis of the studies included, the evidence does not support the supplementation with PA to increase performance or improve body composition in young or elderly men.
Published: 2021

164. A systematic review and meta-analysis of fusion rate enhancements and bone graft options for spine surgery

Author: Wagner M. Tavares, Sabrina Araujo de França, Wellingson S. Paiva, and Manoel J. Teixeira
Subjects: Adult, Ilium, Pseudarthrosis, Multidisciplinary, Bone Transplantation, Spinal Fusion, Treatment Outcome, Humans, Spinal Diseases
Abstract: Our study aimed to evaluate differences in outcomes of patients submitted to spinal fusion using different grafts measuring the effectiveness of spinal fusion rates, pseudarthrosis rates, and adverse events. Applying the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, this systematic review and meta-analysis identified 64 eligible articles. The main inclusion criteria were adult patients that were submitted to spinal fusion, autologous iliac crest (AIC), allograft (ALG), alloplastic (ALP; hydroxyapatite, rhBMP-2, rhBMP-7, or the association between them), and local bone (LB), whether in addition to metallic implants or not, was applied. We made a comparison among those groups to evaluate the presence of differences in outcomes, such as fusion rate, hospital stay, follow-up extension (6, 12, 24, and 48 months), pseudarthrosis rate, and adverse events. Sixty-four studies were identified. LB presented significantly higher proportions of fusion rates (95.3% CI 89.7–98.7) compared to the AIC (88.6% CI 84.8–91.9), ALG (87.8% CI 80.8–93.4), and ALP (85.8% CI 75.7–93.5) study groups. Pseudarthrosis presented at a significantly lower pooled proportion of ALG studies (4.8% CI 0.1–15.7) compared to AIC (8.6% CI 4.2–14.2), ALP (7.1% CI 0.9–18.2), and LB (10.3% CI 1.8–24.5). ALP and AIC studies described significantly more cases of adverse events (80 events/404 patients and 860 events/2001 patients, respectively) compared to LB (20 events/311 patients) and ALG (73 events/459 patients). Most studies presented high risk-of-bias scores. Based on fusion rates and adverse events proportions, LB showed a superior trend among the graft cases we analyzed. However, our review revealed highly heterogeneous data and a need for more rigorous studies to better address and assist surgeons’ choices of the best spinal grafts.
Published: 2021

165. Leishmania infantum Infection in Blood Donors, Northeastern Brazil

Author: Daniela C.S. Monteiro, Anastácio Q. Sousa, Danielle M. Lima, Raissa M. Fontes, Claudênia C. Praciano, Mércia S. Frutuoso, Loraine C. Matos, Maria J. Teixeira, Richard D. Pearson, and Margarida M.L. Pompeu
Subjects: Leishmaniasis, blood donors, Leishmania infantum, parasites, Brazil, sand fly, Medicine, Infectious and parasitic diseases, RC109-216
Published: 2016
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166. Preditores comportamentais e psicossociais da perda e manutenção do peso perdido a longo prazo: uma revisão conceptual de revisões

Author: Rui Jorge, Inês Santos, Vitor Hugo Teixeira, Eliana V. Carraça, and Pedro J. Teixeira
Subjects: Cultural Studies, History, Literature and Literary Theory
Published: 2019
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167. Whey protein in cancer therapy: A narrative review

Author: Gustavo D. Pimentel, Scott L. Howell, Heitor O. Santos, and Filipe J. Teixeira
Subjects: 0301 basic medicine, Whey protein, Cachexia, animal structures, medicine.medical_treatment, Pharmacology, 03 medical and health sciences, fluids and secretions, 0302 clinical medicine, In vivo, Neoplasms, medicine, Animals, Humans, Insulin-Like Growth Factor I, Bovine serum albumin, biology, Lactoferrin, business.industry, digestive, oral, and skin physiology, food and beverages, Cancer, medicine.disease, In vitro, Whey Proteins, 030104 developmental biology, 030220 oncology & carcinogenesis, Dietary Supplements, biology.protein, Leucine, business, Adjuvant
Abstract: Cancer remains a public health challenge in the identification and development of ideal pharmacological therapies and dietary strategies. The use of whey protein as a dietary strategy is widespread in the field of oncology. The two types of whey protein, sweet or acid, result from several processing techniques and possess distinct protein subfraction compositions. Mechanistically, whey protein subfractions have specific anti-cancer effects. Alpha-lactalbumin, human α-lactalbumin made lethal to tumor cell, bovine α-lactalbumin made lethal to tumor cell, bovine serum albumin, and lactoferrin are whey protein subfractions with potential to hinder tumor pathways. Such effects, however, are principally supported by studies performed in vitro and/or in vivo. In clinical practice, whey protein intake-induced anti-cancer effects are indiscernible. However, whey protein supplementation represents a practical, feasible, and cost-effective approach to mitigate cancer cachexia syndrome. The usefulness of whey protein is evidenced by a greater leucine content and the potential to modulate IGF-1 concentrations, representing important factors towards musculoskeletal hypertrophy. Further clinical trials are warranted and needed to establish the effects of whey protein supplementation as an adjuvant to cancer therapy.
Published: 2019
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168. Prevalence and Preferences of Self-Reported Physical Activity and Nonsedentary Behaviors in Portuguese Adults

Author: Pedro J. Teixeira, Jorge Mota, Luís B. Sardinha, Carla Lopes, and Adilson Marques
Subjects: Male, Leisure time, Physical activity, Walking, Developmental psychology, 03 medical and health sciences, Leisure Activities, 0302 clinical medicine, Surveys and Questionnaires, parasitic diseases, Ethnicity, Prevalence, Humans, Orthopedics and Sports Medicine, 030212 general & internal medicine, Exercise, Aged, Portugal, 030229 sport sciences, Sedentary behavior, Middle Aged, language.human_language, language, Female, Self Report, Sedentary Behavior, Portuguese, Psychology, Sports
Abstract: This study describes levels of self-reported physical activity, frequency of selected opportunistic nonsedentary behaviors, and preferences of leisure-time activities in a representative sample of Portuguese adults, using data from a national survey on diet and activity behaviors (National Food, Nutrition and Physical Activity Survey, IAN-AF, 2015-2016).Participants were 3873 Portuguese adults (1827 men). They were interviewed face to face, and the short version of the International Physical Activity Questionnaire was used. Regular leisure-time programmed activities, and 6 additional items, forming the activity choice index questionnaire, were used to assess 6 discrete nonsedentary behaviors.Using the International Physical Activity Questionnaire categories, 42.3% of the sample were classified as low active, 30.6% as moderately active, and 27.1% as highly active. Walking, health/fitness activities, running, group gymnastics classes, swimming/pool activities, football/futsal, and cycling were the most popular leisure-time activities. Between 15% (parking further away from destinations) and 48% (using the stairs instead of elevators) of participants reported that they frequently adopted commonly recommended nonsedentary activities.This study updates self-reported physical activity prevalence for Portugal adults, including older adults. In addition, it uniquely describes leisure-time activity preferences in the population and also the relative frequency of several nonsedentary activities of daily living.
Published: 2019
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169. Power transmission over optical fiber networks.

Author: Paulo S. André, Mário J. N. Lima, António L. J. Teixeira, Rogério N. Nogueira, Lan Chang, Wang Kai, and Xiang-Jun Xin
Published: 2014
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170. Reusable composite membranes for highly efficient chromium removal from real water matrixes

Author: J.M. Queirós, H. Salazar, A. Valverde, G. Botelho, R. Fernández de Luis, J. Teixeira, P.M. Martins, S. Lanceros-Mendez, and Universidade do Minho
Subjects: Chromium, Science & Technology, Environmental Engineering, Health, Toxicology and Mutagenesis, Phthalic Acids, Membrane, Public Health, Environmental and Occupational Health, Water, General Medicine, General Chemistry, Metal-organic frameworks, Pollution, Water remediation, Composite membrane, Fluorocarbon Polymers, Environmental Chemistry, Polyvinyls, Adsorption, Water Pollutants, Chemical, MOF
Abstract: Hexavalent chromium water contamination is still a worldwide concern because this highly mobile ion can cause carcinogenic effects on animals and humans. Therefore, there is an intense research on new active and cost-effective sorbents for Cr(VI), but most of them still exhibit a critical limitation: their powdered nature makes their recovery from water cost and energyconsuming. In this work, Cr(VI) nano-sorbents (i.e., Al(OH)3, MIL-88-B(Fe), and UiO-66- NH2) have been immobilized into a poly (vinylidene fluoride-co-hexafluoropropylene) (PVDFHFP) polymeric substrate to develop an easily reactivable and reusable Cr(VI) filtering technology. The microstructure, morphology, and surface properties of the active nanoparticulated sorbents and the corresponding nanocomposite membranes (NCM) have been characterized from the macrometric to the nanometric scale. The immobilization of the nano sorbent into the PVDF-HFP porous matrix induces a templating effect of the porous structure and allows to tune the hydrophobic/hydrophilic nature of the NCMs. Although a partial blocking of the Cr(VI) adsorptive capacity for Al(OH)3 and MIL-88-B(Fe) based membranes with respect to the pristine nanosorbents was observed, UiO-66-NH2 composite filters maintain the full capacity of the active material to trap Cr(VI), achieving a maximum adsorption capacity of 59.9 mg/g. Despite the slow-down of the Cr(VI) adsorption kinetics of the UiO-66- NH2/PVDF-HFP NCM compared to the active material in suspension, the hybrid system allows easy recovery and activatation, is functionally stable over adsorption-desorption cycling, and is highly robust in terms of efficiency when applied in real effluent water samples., This work was supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Projects UIDB/04650/2020 and UID/QUI/50006/2019 and project PTDC/FIS-MAC/28157/2017. H. Salazar and P.M. Martins thanks the FCT for grants SFRH/BD/122373/2016 and COVID/BD/151786/2021, and contract 2020.02802.CEECIND. Financial support from the Basque Government Industry and Education Departments under the ELKARTEK program is also acknowledged. Ainara Valverde acknowledges the Basque Government (Education Department) for her PhD grant (PREB_2018_1_004) .The European Commission Research & Innovation H2020-MSCA-RISE-2017 (Ref.: 778412) INDESMOF project is also acknowledged. The au-thors thank the technical and human support provided by SGIker (UPV/EHU) .
Published: 2022
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171. Hypertrophic Olivary Degeneration and Holmes' Tremor Secondary to Bleeding of Cavernous Malformation in the Midbrain

Author: Djalma F. S. Menendez, Rubens G. Cury, Egberto R. Barbosa, Manoel J. Teixeira, and Erich T. Fonoff
Subjects: Diseases of the musculoskeletal system, RC925-935, Neurology. Diseases of the nervous system, RC346-429
Abstract: Background: Hypertrophic olivary degeneration (HOD) is a rare phenomenon, probably related to transsynaptic degeneration of the inferior olivary nucleus. It usually occurs as a response to primary injury of dento‐rubro‐olivary pathways.Case report: A young man developed Holmes' tremor 7 months after a cavernous malformation bleed in the midbrain. Typical findings of HOD were observed in the magnetic resonance images: bilateral and asymmetric hypertrophy of the olivary nucleus with slight hypersignal in T2‐weighted images. Because of the striking disability related to drug‐resistant tremor, the patient underwent stereotactic thalamotomy (nucleus ventralis intermedius of the thalamus/zona incerta) with pronounced functional improvement over time.Discussion: Disruption of circuits in the Guillain–Mollaret triangle classically results in palatal myoclonus, however midbrain (Holmes') tremor can also occur, as we now describe.
Published: 2014
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172. Clinical Application of the Fluid Challenge Approach in Goal-Directed Fluid Therapy: What Can We Learn From Human Studies?

Author: Francisco J. Teixeira-Neto and Alexander Valverde
Subjects: Cardiac output, medicine.medical_specialty, Veterinary medicine, Fluid responsiveness, goal-directed fluid therapy, Review, shock, 03 medical and health sciences, 0302 clinical medicine, Fluid therapy, 030202 anesthesiology, Internal medicine, SF600-1100, medicine, fluid responsiveness, General Veterinary, business.industry, cardiac output, 030208 emergency & critical care medicine, Stroke volume, fluid challenge, Preload, Shock (circulatory), Cardiology, Veterinary Science, medicine.symptom, business, Fluid challenge, Venous return curve
Abstract: Resuscitative fluid therapy aims to increase stroke volume (SV) and cardiac output (CO) and restore/improve tissue oxygen delivery in patients with circulatory failure. In individualized goal-directed fluid therapy (GDFT), fluids are titrated based on the assessment of responsiveness status (i.e., the ability of an individual to increase SV and CO in response to volume expansion). Fluid administration may increase venous return, SV and CO, but these effects may not be predictable in the clinical setting. The fluid challenge (FC) approach, which consists on the intravenous administration of small aliquots of fluids, over a relatively short period of time, to test if a patient has a preload reserve (i.e., the relative position on the Frank-Starling curve), has been used to guide fluid administration in critically ill humans. In responders to volume expansion (defined as individuals where SV or CO increases ≥10–15% from pre FC values), FC administration is repeated until the individual no longer presents a preload reserve (i.e., until increases in SV or CO are
Published: 2021
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173. P.0629 Prophylaxis and management of complicated Alcohol Withdrawal Syndromes- approaches beyond benzodiazepines

Author: V. Nogueira, J. Teixeira, and I. Pereira
Subjects: Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical), Biological Psychiatry
Published: 2021
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174. RNA interference mediates RNA toxicity with parent-of-origin effects in C. elegans expressing CTG repeats

Author: Sylvia E. J. Fischer, Maya Braun, Maya Miller, Z. Granot, Yuval Tabach, S. Shoshani, Susana M. D. A. Garcia, J. Teixeira, and A. Mellul-Shtern
Subjects: Genetics, 0303 health sciences, Small interfering RNA, biology, Offspring, RNA, biology.organism_classification, Phenotype, 3. Good health, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, RNA interference, Epigenetics, 030217 neurology & neurosurgery, Caenorhabditis elegans, 030304 developmental biology
Abstract: Nucleotide repeat expansions are a hallmark of over 40 neurodegenerative diseases. These repeats cause RNA toxicity and trigger multisystemic symptoms that worsen with age. RNA toxicity can trigger, through an unclear mechanism, severe disease manifestation in infants that inherited repeats from their mothers. Here we show in Caenorhabditis elegans how RNA interference machinery causes intergenerational toxicity through inheritance of siRNAs derived from CUG repeats. The maternal repeat-derived small RNAs cause transcriptomic changes in the offspring, reduce motility and shorten lifespan. However, the toxicity phenotypes in the offspring can be rescued by perturbing the RNAi machinery in affected mothers. This points to a novel mechanism linking maternal bias and the RNAi machinery and suggests that toxic RNA is transmitted to offspring and causes disease phenotypes through intergenerational epigenetic inheritance.
Published: 2021
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175. One-Year Efficacy and Safety of the PAUL Glaucoma Implant Using a Standardized Surgical Protocol

Author: Patrícia José, Rafael C. Barão, Filipa J. Teixeira, Raquel E. Marques, Riccardo Peschiera, André Barata, and Luís Abegão Pinto
Subjects: Cohort Studies, Prosthesis Implantation, Ophthalmology, Treatment Outcome, Humans, Glaucoma, Glaucoma Drainage Implants, Intraocular Pressure, Follow-Up Studies, Retrospective Studies
Abstract: The PAUL Glaucoma Implant is an effective intraocular pressure (IOP)-lowering device with an acceptable safety profile. Its design as a nonvalved device with a small tube diameter using a vicryl ligation suture around the tube that is posteriorly reabsorbed instead of an ab luminal stent makes it an option in cases selected for glaucoma drainage device implantation.The aim was to determine the 1-year efficacy and safety of PAUL Glaucoma Implant using a uniform, standardized surgical procedure.Retrospective, cohort study. Patient charts were screened between December 2018 and January 2020, with inclusion requiring a minimum follow-up of 12 months. Primary outcome was IOP-lowering at 12 months, with surgical success defined as ≤18 mm Hg and at least 30% reduction and higher than 5 mm Hg. Absolute success was achieved if no IOP-lowering medication was needed and qualified success if otherwise. Safety outcomes were also analyzed. A standardized protocol was followed in all cases, which included mitomycin C application and 1 vicryl ligation of the tube.A total of 24 eyes from 21 patients fulfilled inclusion criteria. Median patient age at time of surgery was 42 years (range: 1 to 76 y). IOP decreased from 31.4 (10.0) mm Hg in preoperative period to 12.5 (4.3) mm Hg in the last follow-up (P0.001). Qualified success criteria were fulfilled by 75% of cases, while absolute success was 33%. The mean number of IOP-lowering drugs used before surgery was 3.0 and 0.9 at the 12-month visit (P0.001). No postoperative hypotony requiring intervention was recorded.PAUL Glaucoma Implant appears to be a safe and effective glaucoma drainage implant for the treatment of moderate and advanced glaucoma.
Published: 2021

176. Psychedelics and Health Behavior Change - Journal of Psychopharmacology (in press)

Author: Christopher Timmermann, Matthew W. Johnson, Pedro J. Teixeira, Hannes Kettner, David Erritzoe, Rosalind Watts, Robin L. Carhart-Harris, and Hannah M. Douglass
Subjects: Psychotherapist, Behavior change, Psychopharmacology, Psychology
Abstract: Healthful behaviors such as maintaining a balanced diet, being physically active, and refraining from smoking have major impacts on the risk of developing cancer, diabetes, cardiovascular diseases, and other serious conditions. The burden of the so-called “lifestyle diseases” - in personal suffering, premature mortality, and public health costs - is considerable. Consequently, interventions designed to promote healthy behaviors are increasingly being studied, e.g. using psychobiological models of behavioral regulation and change. In this article, we explore the notion that psychedelic substances such as psilocybin could be used to assist in promoting positive lifestyle change conducive to good overall health. Psilocybin has a low toxicity, is non-addictive, and has been shown to predict favorable changes in patients with depression, anxiety, and other conditions marked by rigid behavioral patterns, including substance (mis)use. While it is still early days for modern psychedelic science, research is advancing fast and results are promising. Here we describe psychedelics’ proposed mechanisms of action and research findings pertinent to health behavior change science, hoping to generate discussion and new research hypotheses linking the two areas. Therapeutic models including psychedelic experiences and common behavior change methods (e.g., Cognitive Behavior Therapy, Motivational Interviewing) are already being tested for addiction and eating disorders. We believe this research may soon be extended to help promote improved diet, exercise, nature exposure, and also mindfulness or stress reduction practices, all of which can contribute to physical and psychological health and wellbeing.
Published: 2021
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177. From Emergency to the Community: Nursing Care That Promotes Safe Transition of the Person with Increased Vulnerability

Author: Melissa Fernandes, João Rosado, Pedro J. Teixeira, and Cristina P. Monteiro
Subjects: Protocol (science), Service (business), education.field_of_study, Nursing, Population, Psychological intervention, Vulnerability, Nursing Interventions Classification, Transitional care, Emergency department, education, Psychology
Abstract: Readmission to the emergency service after discharge is high, nursing interventions are needed in order to ensure continuity of care after discharge from this service to avoid this phenomenon. Objective: To identify the risk factors for readmissions and describe the interventions that guarantee continuity of care after discharge from the Emergency Department. Methodology: Integrative literature review, following the protocol. The bibliographic sample comprises 7 articles. Results: It is necessary to identify risk factors, personal history, polymedication, the current life situation, age, level of dependence, risk of falling and cognitive function. In nursing, the interventions that stand out the most are the follow-up telephone calls and the existence of an expert nurse in transitional care. Conclusion: The evidence recommends that the existence of structured interventions and an effective articulation of care between the Emergency Department and the Community are good practices to implement and bring health gains to the population studied, however there is a need to further research at this level.
Published: 2021
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178. Development of 3D printing sustainable mortars based on a bibliometric analysis

Author: J. Lino Alves, Bárbara Rangel, CO Schaefer, Maria de Lurdes Lopes, Sandra Nunes, R. J. L. Neto, Lino Maia, J Teixeira, and Faculdade de Engenharia
Subjects: Engineering, Bibliometric analysis, business.industry, Process (engineering), Mechanical Engineering, 0211 other engineering and technologies, 3D printing, 02 engineering and technology, Engineering and technology, 021001 nanoscience & nanotechnology, Technological sciences, Engineering and technology, Mix design, Manufacturing engineering, Ciências Tecnológicas, Ciências da engenharia e tecnologias, 021105 building & construction, Sustainability, Ciências da engenharia e tecnologias, General Materials Science, Mortar, 0210 nano-technology, business
Abstract: In construction, three-dimensional concrete printing technology is an innovative method that opens new design possibilities, reducing the construction time process. The incremental material deposition allows organic shapes without formwork, a mandatory constraint in preparatory phases of conventional complex concrete structures. Nowadays, in three-dimensional printing for construction industry, concrete is the most used material due to its workability, extrudability, and pumpability properties favorable for the printing conditions. Hence, this composition still has a poor sustainable efficiency due to the high levels of Portland Cement. In this research, a reduction of this material was studied and experimented searching for a mortar composition with better ecological footprint, with the objective of decreasing the CO2 emissions. A bibliometric analysis was made to study the constituents of a mortar for three-dimensional printing and respective dosage. The knowledge acquired in the analysis of the compositions contributed to the development of mortars with lower Portland Cement content. A mechanical extruder was used to check the extrusion capacity of the developed mortars, and the best compositions are presented.
Published: 2021

179. Evaluation of a laryngeal mask airway as an alternative to orotracheal intubation for maintaining airway patency during inhalant anesthesia under spontaneous ventilation in capybaras (hydrochoerus hydrochaeris)

Author: Elizabeth Regina Carvalho, Carolina Hagy Girotto, Francisco J. Teixeira-Neto, Mariana Werneck Fonseca, Natache A. Garofalo, André Augusto Justo, Universidade Estadual Paulista (Unesp), and Universidade de São Paulo (USP)
Subjects: Larynx, Mean arterial pressure, General Veterinary, business.industry, General Medicine, Acepromazine, medicine.anatomical_structure, Laryngeal mask airway, Isoflurane, Anesthesia, Breathing, medicine, Midazolam, Animal Science and Zoology, Ketamine, business, medicine.drug
Abstract: Made available in DSpace on 2021-06-25T10:27:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-01 Abstract: Orotracheal intubation carries greater difficulty in rodents than in most domestic species. The human laryngeal mask airway (LMA) was compared with an endotracheal tube (ETtube) for maintaining airway patency in anesthetized capybaras (Hydrochoerus hydrochaeris). Six capybaras (24-52 kg) were remotely darted with intramuscular ketamine, midazolam, and acepromazine on two occasions (≥7-day intervals). After isoflurane mask induction for random placement of an ETtube or a LMA during each episode, anesthesia was maintained with isoflurane in oxygen under spontaneous ventilation for 90-120 min. Computed tomography of the pharynx and larynx was performed in two of six animals and three of six animals with the ETtube and LMA, respectively. End-Tidal isoflurane [median (range)] was not significantly different between ETtube [0.6% (0.5-1.5%)] and LMA [0.6% (0.4-0.9%)]. Heart rate [67 ± 11 beats/min (ETtube) and 67 ± 18 beats/min (LMA)], mean arterial pressure [74 ± 13 mm Hg (ETtube) and 74 ± 14 mm Hg (LMA)], arterial CO2 tension [41 ± 2 mm Hg (ETtube) and 43 ± 4 mm Hg (LMA)], and arterial O2 tension [360 ± 59 mm Hg (ETtube) and 360 ± 63 mm Hg (LMA)] were not significantly different between treatment groups. Computed tomography showed gas in the esophagus with the LMA (three of three animals); the fit of the LMA to the larynx was adequate in two of three animals and fair in one of three animals. Recovery from anesthesia was uneventful. The LMA is a feasible alternative to the ETtube for maintaining airway patency during inhalant anesthesia in spontaneously breathing capybaras. However, the LMA may be dislodged during movement of the animal. Universidade Estadual Paulista (Unesp) Faculdade de Medicina Campus de Botucatu Cep 18618-687 Universidade Estadual Paulista (Unesp) Faculdade de Medicina Veterina Ria e Zootecnia Campus de Botucatu Cep 18618-681 Universidade de Sa O Paulo (USP) Faculdade de Medicina Veterina Ria e Zootecnia Cep 05508-270 Universidade Estadual Paulista (Unesp) Faculdade de Cieˆncias Agra Rias e Veterina Rias Campus de Jaboticabal Cep 14884-900 Universidade Estadual Paulista (Unesp) Faculdade de Medicina Campus de Botucatu Cep 18618-687 Universidade Estadual Paulista (Unesp) Faculdade de Medicina Veterina Ria e Zootecnia Campus de Botucatu Cep 18618-681 Universidade Estadual Paulista (Unesp) Faculdade de Cieˆncias Agra Rias e Veterina Rias Campus de Jaboticabal Cep 14884-900
Published: 2021

180. Use of aortic flow indexes derived from transthoracic echocardiography to evaluate response to a fluid challenge in anesthetized dogs

Author: Angélica Alfonso, Guillermo Carlos Veiga de Oliveira, Francisco J. Teixeira-Neto, Tábata L. Dalmagro, Nathalia Celeita-Rodríguez, Maria Lucia Gomes Lourenço, César Passareli Cândido Lobo, and Universidade Estadual Paulista (Unesp)
Subjects: Mean arterial pressure, 040301 veterinary sciences, Fluid responsiveness, goal-directed fluid therapy, 0403 veterinary science, velocity time integral, 03 medical and health sciences, Dogs, 0302 clinical medicine, 030202 anesthesiology, fluid responsiveness, Animals, Medicine, Prospective Studies, Elective surgery, Isoflurane, General Veterinary, Receiver operating characteristic, business.industry, Hemodynamics, Stroke Volume, 04 agricultural and veterinary sciences, Stroke volume, Aortic flow, Respiration, Artificial, Echocardiography, Anesthesia, Fluid Therapy, Velocity time integral, business, Fluid challenge
Abstract: Made available in DSpace on 2021-06-25T10:51:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-01 Objective: To evaluate the ability of transthoracic echocardiographic aortic flow measurements to discriminate response to a fluid challenge (FC) in healthy anesthetized dogs. Study design: Prospective experimental study. Animals: A total of 48 isoflurane-anesthetized dogs (14.2–35.0 kg) undergoing elective surgery. Methods: Fluid responsiveness was evaluated before surgery by FC (lactated Ringer's 10 mL kg–1 intravenously over 5 minutes). Percentage increases in transpulmonary thermodilution stroke volume (ΔSVTPTD) >15% from values recorded before FC defined responders to volume expansion. A group of 24 animals were assigned as nonresponders (ΔSVTPTD ≤15%). When ΔSVTPTD was >15% after the first FC, additional FC were administered until ΔSVTPTD was ≤15%. Final fluid responsiveness status was based on the response to the last FC. Percentage increases after FC in aortic flow indexes [velocity time integral (ΔVTIFC) and maximum acceleration (ΔVmaxFC)] and in mean arterial pressure (ΔMAPFC) were compared with ΔSVTPTD. Results: After one FC, 24 animals were responders. For nonresponders, ΔSVTPTD was ≤15% after one, two and three FCs in eight/24, 15/24 and one/24 animals, respectively. The FC that defined responsiveness increased ΔSVTPTD by 29 (18–53)% in responders and by 8 (–3 to 15)% in nonresponders [mean (range)]. The area under the receiver operating characteristics curve (AUROC) of ΔVTIFC (0.901) was larger than the AUROCs of ΔVmaxFC (0.774, p = 0.041) and ΔMAPFC (0.519, p < 0.0001). ΔMAPFC did not predict responsiveness (p = 0.826). Best cut-off thresholds for discriminating responders, with respective zones of diagnostic uncertainty (gray zones) were >14.7 (10.8–17.6)% for ΔVTIFC and >8.6 (–0.3 to 14.7)% for ΔVmaxFC. Animals within the gray zone were 17% (ΔVTIFC) and 50% (ΔVmaxFC). Conclusions and clinical relevance: Changes in VTI induced by FC can determine responsiveness with reasonable accuracy in dogs and could play an important role in goal-directed fluid therapy. Department of Veterinary Surgery and Animal Reproduction Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (UNESP) Department of Anesthesiology Faculdade de Medicina Universidade Estadual Paulista (UNESP) Department of Veterinary Surgery and Animal Reproduction Faculdade de Medicina Veterinária e Zootecnia Universidade Estadual Paulista (UNESP) Department of Anesthesiology Faculdade de Medicina Universidade Estadual Paulista (UNESP)
Published: 2021

181. Association between Phase Angle from Bioelectric Impedance and Muscular Strength and Power in Physically Active Adults

Author: Aryanne Hydeko Fukuoka, Núbia Maria de Oliveira, Catarina N. Matias, Filipe J. Teixeira, Cristina P. Monteiro, Maria J. Valamatos, Joana F. Reis, and Ezequiel Moreira Gonçalves
Subjects: General Immunology and Microbiology, General Agricultural and Biological Sciences, General Biochemistry, Genetics and Molecular Biology, phase angle, muscle power, muscle strength, body composition
Abstract: This study aimed to compare muscle strength and power indicators according to bioimpedance spectroscopy’s phase angle (PhA) values, in resistance-trained (RT) men, while exploring associations between PhA and performance. Forty-four men aged 18–45 years, engaged in RT, were allocated according to PhA tertiles. Lean soft tissue (LST) and fat mass (%FM) were assessed using dual-energy x-ray absorptiometry; dynamic muscle strength using 1 repetition maximum (1RM) of bench press (BP) and back squat (BS) and muscle power using Wingate test (WT) and countermovement jump (CMJ). For WT and CMJ, the 3rd tertile was significantly higher than the 1st tertile (p = 0.027 and p = 0.018, respectively). Regarding BP 1RM, the 3rd tertile was significantly higher than the 2nd tertile (p = 0.037). LST better explained the variability in the WT, BS and BP (p =< 0.001), while %FM better accounted for jump height in CMJ (p =< 0.001). PhA was a predictor of performance in both CMJ (p = 0.040) and BP (p = 0.012), independently of LST and %FM. Participants with higher PhA also displayed superior muscle strength of the upper limbs and greater muscle power of the lower limbs. PhA displayed significant moderate associations with performance in CMJ and BP, even after controlling for body composition. Still, LST was the most important predictor of muscle strength and power.
Published: 2022
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182. Synthesis and magnetic properties of two cobalt-coordination polymers containing 1,10-phenanthroline and alkyl dicarboxylates ligands

Author: Filipe J. Teixeira, Leonã S. Flores, Talita Valverde, Lívia B.L. Escobar, Mario S. Reis, and Charlane C. Corrêa
Subjects: Inorganic Chemistry, Organic Chemistry, Spectroscopy, Analytical Chemistry
Published: 2022
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183. Embryological, clinical and ultrastructural study of human oocytes presenting indented zona pellucida

Author: Sousa, M., da Silva, J. Teixeira, Silva, J., Cunha, M., Viana, P., Oliveira, E., Sá, R., Soares, C., Oliveira, C., and Barros, A.
Published: 2015

184. Right inferior frontal gyrus activation is associated with memory improvement in patients with left frontal low-grade glioma resection.

Author: Eliane C Miotto, Joana B Balardin, Gilson Vieira, Joao R Sato, Maria da Graça M Martin, Milberto Scaff, Manoel J Teixeira, and Edson Amaro Junior
Subjects: Medicine, Science
Abstract: Patients with low-grade glioma (LGG) have been studied as a model of functional brain reorganization due to their slow-growing nature. However, there is no information regarding which brain areas are involved during verbal memory encoding after extensive left frontal LGG resection. In addition, it remains unknown whether these patients can improve their memory performance after instructions to apply efficient strategies. The neural correlates of verbal memory encoding were investigated in patients who had undergone extensive left frontal lobe (LFL) LGG resections and healthy controls using fMRI both before and after directed instructions were given for semantic organizational strategies. Participants were scanned during the encoding of word lists under three different conditions before and after a brief period of practice. The conditions included semantically unrelated (UR), related-non-structured (RNS), and related-structured words (RS), allowing for different levels of semantic organization. All participants improved on memory recall and semantic strategy application after the instructions for the RNS condition. Healthy subjects showed increased activation in the left inferior frontal gyrus (IFG) and middle frontal gyrus (MFG) during encoding for the RNS condition after the instructions. Patients with LFL excisions demonstrated increased activation in the right IFG for the RNS condition after instructions were given for the semantic strategies. Despite extensive damage in relevant areas that support verbal memory encoding and semantic strategy applications, patients that had undergone resections for LFL tumor could recruit the right-sided contralateral homologous areas after instructions were given and semantic strategies were practiced. These results provide insights into changes in brain activation areas typically implicated in verbal memory encoding and semantic processing.
Published: 2014
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185. Erector spinae plane (ESP) block in the thoracolumbar spine: a canine cadaveric study

Author: Roger Medina-Serra, Pablo E. Otero, Diego A. Portela, Marta Romano, M. Cavalcanti, R. Johnson, J. Teixeira, and A. Stern
Subjects: General Veterinary, Plane (geometry), business.industry, Anesthesia, Block (telecommunications), Thoracolumbar spine, Medicine, Anatomy, Cadaveric spasm, business
Published: 2021
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186. What goes on in digital behaviour change interventions for weight loss maintenance targeting physical activity: A Scoping Review (Preprint)

Author: Jorge Encantado, António L. Palmeira, Carolina Silva, Falko F. Sniehotta, R. James Stubbs, Maria J. Gouveia, Pedro J. Teixeira, Berit L. Heitmann, and Marta M. Marques
Abstract: BACKGROUND Behavioural interventions for weight loss maintenance have shown beneficial effects for weight loss maintenance. While the digital upgrade of behavioural interventions brings an enormous potential to tackle public health challenges, there is limited knowledge about the components of these interventions, i.e., its content, delivery and the theoretical approaches. OBJECTIVE To identify the core components of digital behaviour change interventions for weight loss maintenance targeting physical activity, in terms of: i) Behaviour Change Techniques; ii) Mechanisms of Action; iii) Modes of Delivery; iv) Dose; and v) Tailoring/Personalisation. In addition, the links between these components were investigated. METHODS A literature search was performed in 5 electronic databases: PubMed; Embase; CINHAL; PsycINFO, and Web of Science. Two reviewers independently screened the identified papers and extracted data related with the study characteristics and behaviour change techniques, mechanism of action, mode of delivery, dose, and tailoring, using standardized classifications whenever available (e.g., behaviour change techniques taxonomy). RESULTS Seventeen articles reporting eleven original studies were selected. Two studies were protocols, nine studies presented results for weight change and all but one showed no significant differences between the intervention and control groups. Eight studies (73%) provided adequate information on Behaviour Change Techniques. Five studies (45%) provided partial information about how the Behaviour Change Techniques were linked to mechanisms of action, and only one study (0.9%) described these links for all the techniques. Around half of the studies reported the modes through which behaviour change techniques were delivered. Descriptions of dose were present in most studies, but with minimal information. The use of tailoring or personalisation approaches was mentioned in eight studies (73%), but descriptions of what was tailored and how were minimal. CONCLUSIONS The compilation of information regarding intervention components was difficult due to the lack of information and systematisation in reporting across papers. This is particularly true for the reporting of the links between behaviour change techniques and the other core intervention components. This information is crucial to help us understand in the context of behaviour change interventions what works or does not work, how it works and why.
Published: 2021
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187. The authors reply

Author: Sabrina Araujo de França, Wagner M. Tavares, Angela S. M. Salinet, Wellingson S. Paiva, and Manoel J. Teixeira
Subjects: Critical Care and Intensive Care Medicine
Published: 2021

188. Leucine metabolites do not induce changes in phase angle, bioimpedance vector analysis patterns, and strength in resistance trained men

Author: Joana F. Reis, Cristina P. Monteiro, Maria J. Valamatos, Stefania Toselli, Filipe J. Teixeira, Catarina N. Matias, Francesco Campa, Campa F., Matias C.N., Teixeira F.J., Reis J.F., Valamatos M.J., Toselli S., and Monteiro C.P.
Subjects: Adult, Male, Physiology, Endocrinology, Diabetes and Metabolism, Metabolite, Performance-Enhancing Substance, 030209 endocrinology & metabolism, Performance-Enhancing Substances, BIVA, Body composition, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Text mining, Absorptiometry, Photon, Leucine, Physiology (medical), Electric Impedance, Humans, Dietary Supplement, Nutrition and Dietetics, business.industry, Phase angle, Resistance training, R-Xc graph, Resistance Training, 030229 sport sciences, General Medicine, Middle Aged, Biochemistry, chemistry, Dietary Supplements, business, Human
Abstract: We aimed to assess the effects of off-the-shelf leucine metabolite supplements on phase angle (PhA), bioimpedance vector analysis (BIVA) patterns and strength during an 8-week resistance training protocol. Fifty-three male participants were allocated into 4 groups: α-hydroxyisocaproic acid (n = 12, age = 30.9 ± 9.3 years), β-hydroxy-β-methylbutyrate free acid (n = 12, age = 31.0 ± 9.3 years), calcium β-hydroxy-β-methylbutyrate (n = 15, age = 32.1 ± 5.2 years) or placebo (n = 14, age = 28.9 ± 6.6 years). Bioimpedance parameters and 1-repetition maximum (1RM) for back squat and bench press were assessed at baseline and at the end of weeks 4 and 8. Additionally, fat-free mass and fat mass were evaluated by dual-energy X-ray absorptiometry. No statistically group by time interactions were found, even adjusting for age. PhA and vector did not change over the training period, while time-dependent increases were observed for 1RM back squat and 1RM bench press. A direct association was observed between PhA and 1RM bench press changes (whole sample), while PhA and strength were correlated throughout the study, even when adjusting for fat-free mass and percentage of fat mass. Leucine metabolites have no effect on PhA, BIVA patterns or strength during an 8-week resistance training program, in resistance trained subjects. The trial was registered at ClincicalTrials.gov: NCT03511092. Novelty: Supplementation with leucine metabolites is not a supplementation strategy that improves bioelectrical phase angle, cellular health, and strength after an 8-week resistance training program. When consuming a high protein diet, none of the α-hydroxyisocaproic acid, β-hydroxy-β-methylbutyrate free acid, and calcium β-hydroxy-β-methylbutyrate metabolites resulted in an ergogenic effect in resistance trained men.
Published: 2021

189. Contributors

Author: Rubén Agregán, Francisco J. Barba, Houda Berrada, Benjamin Bohrer, Tomislav Bosiljkov, Mladen Brnčić, Louis Chonco, Patricia Costa, Vilaine Corrêa da Silva, Pablo G. del Río, Rubén Domínguez, Mohamed A. Farag, Xi Feng, Emilia Ferrer, Gislaine Fongaro, Mohammed Gagaoua, Andrés García, Beatriz Gullón, Patricia Gullón, Anet Režek Jambrak, Damir Ježek, Sven Karlović, Tomás Landete-Castillejos, Juliano De Dea Lindner, José Manuel Lorenzo, Herbert L. Meiselman, Marília Miotto, Jane M. Misihairabgwi, Paulo Eduardo Sichetti Munekata, Iwona Niedźwiedź, Marinela Nutrizio, Diana Oliveira, Noelia Pallarés, Mirian Pateiro, Ricardo N. Pereira, Cristina Pérez-Santaescolastica, Magdalena Polak-Berecka, Rui M. Rodrigues, David Rodríguez-Lázaro, Martina P. Serrano, Doris Sobral Marques Souza, António J. Teixeira, Igor Tomasevic, Theodoros Varzakas, António A. Vicente, Min Wang, Lujuan Xing, Sol Zamuz, Wangang Zhang, and Jianjun Zhou
Published: 2021
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190. A Perspective of Competitiveness and Tourist Innovation in the Hotel Sector of Madeira Island

Author: Sérgio J. Teixeira
Subjects: Hospitality, business.industry, Excellence, media_common.quotation_subject, Quality (business), Customer satisfaction, Economic geography, business, Competitive advantage, Comparative advantage, Tourism, media_common, Theme (narrative)
Abstract: The characterization of tourism competitiveness in a given location is a relevant topic, both in the analysis of the current situation of tourism activity and in planning and development. The aim of this chapter is to reference scientific publications taking into account the knowledge underlying this theme and to give notoriety to this theme, describing the factors that trigger and condition this competitiveness. The indispensability of tourism innovation and the positive and negative impact that the region has on this phenomenon will be addressed. In addition, we will discuss the need to provide services of excellence and quality to promote a competitive advantage in relation to other countries. Finally, the attractive status that RAM has in relation to other countries will be revealed. The study addresses some literary criticisms that respond to the tourist competitiveness of the Autonomous Region of Madeira. This analysis counted on the collaboration of chapters and papers published between 2016 and 2019. The results show how the intellectual structure on regional competitiveness influences tourism and is influenced by four crucial characteristics: the environment in which tourism is inserted, the infrastructure network of transport and hospitality, innovation, price competitiveness, and the culmination of comparative advantages reflected by the nature and culture of the destination.
Published: 2021
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191. Socio-demographic factors associated with physical activity and sitting time patterns in adults: An analysis based on the Portuguese Food, Nutrition and Physical Activity Survey

Author: Carla Lopes, Adilson Marques, Pedro J. Teixeira, Paulo Nicola, Jorge Mota, João Martins, Instituto de Saúde Pública da Universidade do Porto, and Repositório da Universidade de Lisboa
Subjects: Adult, Male, medicine.medical_specialty, lifestyle, Time Factors, Adolescent, Socio demographics, sedentary living, Physical activity, 030209 endocrinology & metabolism, Physical Therapy, Sports Therapy and Rehabilitation, Lower risk, Logistic regression, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Sex Factors, Surveys and Questionnaires, medicine, Humans, quantitative study, Orthopedics and Sports Medicine, Behaviour, Exercise, Sitting Position, Portugal, exercise, Public health, Age Factors, 030229 sport sciences, General Medicine, Sedentary living, Middle Aged, Lifestyle, language.human_language, Sitting time, behaviour, Socioeconomic Factors, language, Household income, Female, Portuguese, Sedentary Behavior, Psychology, Quantitative study, Demography
Abstract: © 2020 European College of Sport Science, Physical activity (PA) and sedentary behaviours (SB) influence health. Since most people engage in different combinations of both behaviours every day, understanding the socio-demographic characteristics of adults with distinct PA and sitting time (ST) patterns is important to contribute to evidence-based planning of public health strategies. Data from a national survey on diet and activity behaviours (IAN-AF, 2015/16) including 1724 adults (50.5% women, 18–64 years) from a representative sample of Portuguese adults was used in this study. Participants were interviewed face-to-face, and the International Physical Activity Questionnaire (IPAQ) was used. Logistic regression examined the associations between socio-demographic factors each of the four-low/high PA-ST groups. PA low/high categories were defined as in IPAQ, while ST low/high categories were defined according to ST tertiles (≤180 min/day, ≥360 min/day). A ‘higher risk’ behaviour pattern (low PA/high ST) was present in 37.3% of the adults and was likely associated with a middle household income, and with having 12 or more years of education. The ‘lower risk’ (high PA/low ST) represented 26.6% of the sample and was likely associated with middle-aged adults and with having a lower educational level. Being male, young and highly educated was related to being physically active and spending large amounts of time in ST. Besides adding to the body of mixed evidence on this theme, the identification of the socio-demographic factors associated with each PA/ST pattern will permit national public health authorities to define policies and tailored actions to promote PA and reduce ST., This work was supported by EEA Grants Program, Public Health Initiatives: [Grant Number PT06-000088SI3].
Published: 2021

192. Mortality risk attributable to wildfire-related PM2·5 pollution: a global time series study in 749 locations

Author: Chen, G. Guo, Y. Yue, X. Tong, S. Gasparrini, A. Bell, M.L. Armstrong, B. Schwartz, J. Jaakkola, J.J.K. Zanobetti, A. Lavigne, E. Nascimento Saldiva, P.H. Kan, H. Royé, D. Milojevic, A. Overcenco, A. Urban, A. Schneider, A. Entezari, A. Vicedo-Cabrera, A.M. Zeka, A. Tobias, A. Nunes, B. Alahmad, B. Forsberg, B. Pan, S.-C. Íñiguez, C. Ameling, C. De la Cruz Valencia, C. Åström, C. Houthuijs, D. Van Dung, D. Samoli, E. Mayvaneh, F. Sera, F. Carrasco-Escobar, G. Lei, Y. Orru, H. Kim, H. Holobaca, I.-H. Kyselý, J. Teixeira, J.P. Madureira, J. Katsouyanni, K. Hurtado-Díaz, M. Maasikmets, M. Ragettli, M.S. Hashizume, M. Stafoggia, M. Pascal, M. Scortichini, M. de Sousa Zanotti Stagliorio Coêlho, M. Valdés Ortega, N. Ryti, N.R.I. Scovronick, N. Matus, P. Goodman, P. Garland, R.M. Abrutzky, R. Garcia, S.O. Rao, S. Fratianni, S. Dang, T.N. Colistro, V. Huber, V. Lee, W. Seposo, X. Honda, Y. Guo, Y.L. Ye, T. Yu, W. Abramson, M.J. Samet, J.M. Li, S.
Abstract: BACKGROUND: Many regions of the world are now facing more frequent and unprecedentedly large wildfires. However, the association between wildfire-related PM2·5 and mortality has not been well characterised. We aimed to comprehensively assess the association between short-term exposure to wildfire-related PM2·5 and mortality across various regions of the world. METHODS: For this time series study, data on daily counts of deaths for all causes, cardiovascular causes, and respiratory causes were collected from 749 cities in 43 countries and regions during 2000-16. Daily concentrations of wildfire-related PM2·5 were estimated using the three-dimensional chemical transport model GEOS-Chem at a 0·25° × 0·25° resolution. The association between wildfire-related PM2·5 exposure and mortality was examined using a quasi-Poisson time series model in each city considering both the current-day and lag effects, and the effect estimates were then pooled using a random-effects meta-analysis. Based on these pooled effect estimates, the population attributable fraction and relative risk (RR) of annual mortality due to acute wildfire-related PM2·5 exposure was calculated. FINDINGS: 65·6 million all-cause deaths, 15·1 million cardiovascular deaths, and 6·8 million respiratory deaths were included in our analyses. The pooled RRs of mortality associated with each 10 μg/m3 increase in the 3-day moving average (lag 0-2 days) of wildfire-related PM2·5 exposure were 1·019 (95% CI 1·016-1·022) for all-cause mortality, 1·017 (1·012-1·021) for cardiovascular mortality, and 1·019 (1·013-1·025) for respiratory mortality. Overall, 0·62% (95% CI 0·48-0·75) of all-cause deaths, 0·55% (0·43-0·67) of cardiovascular deaths, and 0·64% (0·50-0·78) of respiratory deaths were annually attributable to the acute impacts of wildfire-related PM2·5 exposure during the study period. INTERPRETATION: Short-term exposure to wildfire-related PM2·5 was associated with increased risk of mortality. Urgent action is needed to reduce health risks from the increasing wildfires. FUNDING: Australian Research Council, Australian National Health & Medical Research Council. Copyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. Published by Elsevier Ltd.. All rights reserved.
Published: 2021

193. Elective cancer surgery in COVID-19–Free surgical pathways during the SARS-cov-2 pandemic: An international, multicenter, comparative cohort study

Author: James C Glasbey, Dmitri Nepogodiev, Joana Ff Simoes, Omar Omar, Elizabeth Li, Mary L Venn, Mohammad Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G Edwards, Jonathan P Evans, Marco Fiore, Jose Flavio Videria, Samuel J Ford, Ian Ganyli, Ewen A Griffiths, Rohan R Gujjuri, Angelos G Kolias, Haytham Ma Kaafarani, Ana Minaya-Bravo, Siobhan C McKay, Helen M Mohan, Keith Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J Smart, Grant D Stewart, Sudha Sundar, Raghavan Vidya, Aneel A Bhangu, James C Glasbey, Omar Omar, Aneel A Bhangu, Kwabena Siaw-Acheampong, Ruth A Benson, Edward Bywater, Daoud Chaudhry, Brett E Dawson, Jonathan P Evans, James C Glasbey, Rohan R Gujjuri, Emily Heritage, Conor S Jones, Sivesh K Kamarajah, Chetan Khatri, Rachel A Khaw, James M Keatley, Andrew Knight, Samuel Lawday, Elizabeth Li, Harvinder S Mann, Ella J Marson, Kenneth A McLean, Siobhan C McKay, Emily C Mills, Dmitri Nepogodiev, Gianluca Pellino, Maria Picciochi, Elliott H Taylor, Abhinav Tiwari, Joana Ff Simoes, Isobel M Trout, Mary L Venn, Richard Jw Wilkin, Aneel A Bhangu, James C Glasbey, Neil J Smart, Ana Minaya-Bravo, Jonathan P Evans, Gaetano Gallo, Susan Moug, Francesco Pata, Peter Pockney, Salomone Di Saverio, Abigail Vallance, Dale Vimalchandran, Ewen A Griffiths, Sivesh K Kamarajah, Richard Pt Evans, Philip Townend, Keith Roberts, Siobhan McKay, John Isaac, Sohei Satoi, John Edwards, Aman S Coonar, Adrian Marchbank, Edward J Caruana, Georgia R Layton, Akshay Patel, Alessandro Brunelli, Samuel Ford, Anant Desai, Alessandro Gronchi, Marco Fiore, Max Almond, Fabio Tirotta, Sinziana Dumitra, Angelos Kolias, Stephen J Price, Daniel M Fountain, Michael D Jenkinson, Peter Hutchinson, Hani J Marcus, Rory J Piper, Laura Lippa, Franco Servadei, Ignatius Esene, Christian Freyschlag, Iuri Neville, Gail Rosseau, Karl Schaller, Andreas K Demetriades, Faith Robertson, Alex Alamri, Richard Shaw, Andrew G Schache, Stuart C Winter, Michael Ho, Paul Nankivell, Juan Rey Biel, Martin Batstone, Ian Ganly, Raghavan Vidya, Alex Wilkins, Jagdeep K Singh, Dinesh Thekinkattil, Sudha Sundar, Christina Fotopoulou, Elaine Leung, Tabassum Khan, Luis Chiva, Jalid Sehouli, Anna Fagotti, Paul Cohen, Murat Gutelkin, Rahel Ghebre, Thomas Konney, Rene Pareja, Rob Bristow, Sean Dowdy, T S Shylasree, R Kottayasamy Seenivasagam, Joe Ng, Keiiji Fujiwara, Grant D Stewart, Benjamin Lamb, Krishna Narahari, Alan McNeill, Alexandra Colquhoun, John McGrath, Steve Bromage, Ravi Barod, Veeru Kasivisvanathan, Tobias Klatte, Joana Ff Simoes, Tom Ef Abbott, Sadi Abukhalaf, Michel Adamina, Adesoji O Ademuyiwa, Arnav Agarwal, Murat Akkulak, Ehab Alameer, Derek Alderson, Felix Alakaloko, Markus Albertsmeiers, Osaid Alser, Muhammad Alshaar, Sattar Alshryda, Alexis P Arnaud, Knut Magne Augestad, Faris Ayasra, José Azevedo, Brittany K Bankhead-Kendall, Emma Barlow, David Beard, Ruth A Benson, Ruth Blanco-Colino, Amanpreet Brar, Ana Minaya-Bravo, Kerry A Breen, Chris Bretherton, Igor Lima Buarque, Joshua Burke, Edward J Caruana, Mohammad Chaar, Sohini Chakrabortee, Peter Christensen, Daniel Cox, Moises Cukier, Miguel F Cunha, Giana H Davidson, Anant Desai, Salomone Di Saverio, Thomas M Drake, John G Edwards, Muhammed Elhadi, Sameh Emile, Shebani Farik, Marco Fiore, J Edward Fitzgerald, Samuel Ford, Tatiana Garmanova, Gaetano Gallo, Dhruv Ghosh, Gustavo Mendonça Ataíde Gomes, Gustavo Grecinos, Ewen A Griffiths, Madalegna GrÜndl, Constantine Halkias, Ewen M Harrison, Intisar Hisham, Peter J Hutchinson, Shelley Hwang, Arda Isik, Michael D Jenkinson, Pascal Jonker, Haytham Ma Kaafarani, Debby Keller, Angelos Kolias, Schelto Kruijff, Ismail Lawani, Hans Lederhuber, Sezai Leventoglu, Andrey Litvin, Andrew Loehrer, Markus W Löffler, Maria Aguilera Lorena, Maria Marta Modolo, Piotr Major, Janet Martin, Hassan N Mashbari, Dennis Mazingi, Symeon Metallidis, Ana Minaya-Bravo, Helen M Mohan, Rachel Moore, David Moszkowicz, Susan Moug, Joshua S Ng-Kamstra, Mayaba Maimbo, Ionut Negoi, Milagros Niquen, Faustin Ntirenganya, Maricarmen Olivos, Kacimi Oussama, Oumaima Outani, Marie Dione Parreno-Sacdalanm, Francesco Pata, Carlos Jose Perez Rivera, Thomas D Pinkney, Willemijn van der Plas, Peter Pockney, Ahmad Qureshi, Dejan Radenkovic, Antonio Ramos-De la Medina, Keith Roberts, April C Roslani, Martin Rutegård, Juan José Segura-Sampedro, Irène Santos, Sohei Satoi, Raza Sayyed, Andrew Schache, Andreas A Schnitzbauer, Justina O Seyi-Olajide, Neil Sharma, Richard Shaw, Sebastian Shu, Kjetil Soreide, Antonino Spinelli, Grant D Stewart, Malin Sund, Sudha Sundar, Stephen Tabiri, Philip Townend, Georgios Tsoulfas, Gabrielle H van Ramshorst, Raghavan Vidya, Dale Vimalachandran, Oliver J Warren, Duane Wedderburn, Naomi Wright, C Allemand, L Boccalatte, M Figari, M Lamm, J Larrañaga, C Marchitelli, F Noll, D Odetto, M Perrotta, J Saadi, L Zamora, C Alurralde, E L Caram, D Eskinazi, J P Mendoza, M Usandivaras, R Badra, A Esteban, J S García, P M García, J I Gerchunoff, S M Lucchini, M A NIgra, L Vargas, T Hovhannisyan, A Stepanyan, T Gould, R Gourlay, B Griffiths, S Gananadha, M McLaren, J Cecire, N Joshi, S Salindera, A Sutherland, J H Ahn, G Charlton, S Chen, N Gauri, R Hayhurst, S Jang, F Jia, C Mulligan, W Yang, G Ye, H Zhang, M Ballal, D Gibson, D Hayne, J Moss, T Richards, P Viswambaram, U G Vo, J Bennetts, T Bright, M Brooke-Smith, R Fong, B Gricks, Y H Lam, B S Ong, M Szpytma, D Watson, K Bagraith, S Caird, E Chan, C Dawson, D Ho, E Jeyarajan, S Jordan, A Lim, G J Nolan, A Oar, D Parker, H Puhalla, A Quennell, L Rutherford, P Townend, M Von Papen, M Wullschleger, A Blatt, D Cope, N Egoroff, M Fenton, J Gani, N Lott, P Pockney, N Shugg, M Elliott, D Phung, D Phan, D Townend, C Bong, J Gundara, A Frankel, S Bowman, G R Guerra, J Bolt, K Buddingh, N N Dudi-Venkata, S Jog, H M Kroon, T Sammour, R Smith, C Stranz, M Batstone, K Lah, W McGahan, D Mitchell, A Morton, A Pearce, M Roberts, G Sheahan, B Swinson, N Alam, S Banting, L Chong, P Choong, S Clatworthy, D Foley, A Fox, M W Hii, B Knowles, J Mack, M Read, A Rowcroft, S Ward, G Wright, M Lanner, I Königsrainer, M Bauer, C Freyschlag, M Kafka, F Messner, D Öfner, I Tsibulak, K Emmanuel, M Grechenig, R Gruber, M Harald, L Öhlberger, J Presl, A Wimmer, I Namazov, E Samadov, D Barker, R Boyce, S Corbin, A Doyle, A Eastmond, R Gill, A Haynes, S Millar, M O'Shea, G Padmore, N Paquette, E Phillips, S St John, K Walkes, N Flamey, P Pattyn, W Oosterlinck, J Van den Eynde, R Van den Eynde, A Gatti, C Nardi, R Oliva, R De Cicco, I Cecconello, P Gregorio, L Pontual Lima, U Ribeiro Junior, F Takeda, R M Terra, M Sokolov, B Kidane, S Srinathan, M Boutros, N Caminsky, G Ghitulescu, G Jamjoum, J Moon, J Pelletier, T Vanounou, S Wong, M Boutros, S Dumitra, A Kouyoumdjian, B Johnston, C Russell, M Boutros, S Demyttenaere, R Garfinkle, J Abou-Khalil, C Nessim, J Stevenson, F Heredia, A Almeciga, A Fletcher, A Merchan, L O Puentes, J Mendoza Quevedo, G Bacic, D Karlovic, D Krsul, M Zelic, I Luksic, M Mamic, B Bakmaz, I Coza, E Dijan, Z Katusic, J Mihanovic, I Rakvin, K Frantzeskou, N Gouvas, G Kokkinos, P Papatheodorou, I Pozotou, O Stavrinidou, A Yiallourou, L Martinek, M Skrovina, I Szubota, J Žatecký, V Javurkova, J Klat, T Avlund, P Christensen, J L Harbjerg, L H Iversen, D W Kjaer, Hø Kristensen, M Mekhael, A L Ebbehøj, P Krarup, N Schlesinger, H Smith, A Abdelsamed, A Y Azzam, H Salem, A Seleim, A Abdelmajeed, M Abdou, N E Abosamak, M Al Sayed, F Ashoush, R Atta, E Elazzazy, M Elhoseiny, M Elnemr, M S Elqasabi, M E Elsayed Hewalla, I Elsherbini, E Essam, M Eweda, I Ghallab, E Hassan, M Ibrahim, M Metwalli, M Mourad, M S Qatora, M Ragab, A Sabry, H Saifeldin, M Saleh Mesbah Mohamed Elkaffas, A Samih, A Samir Abdelaal, S Shehata, K Shenit, D Attia, N Kamal, N Osman, A M Abbas, Has Abd Elazeem, M M Abdelkarem, S Alaa, A K Ali, A Ayman, M G Azizeldine, H Elkhayat, S M Elghazaly, F A Monib, M A Nageh, M M Saad, M Salah, M Shahine, E A Yousof, A Youssef, A Eldaly, M ElFiky, A Nabil, G Amira, I Sallam, M Sherief, A Sherif, A Abdelrahman, H Aboulkassem, G Ghaly, R Hamdy, A Morsi, H Salem, G Sherif, H Abdeldayem, I Abdelkader Salama, M Balabel, Y Fayed, A E Sherif, D Bekele, J Kauppila, E Sarjanoja, O Helminen, H Huhta, J H Kauppila, C Beyrne, L Jouffret, L Lugans, L Marie-Macron, E Chouillard, B De Simone, J Bettoni, S Dakpé, B Devauchelle, N Lavagen, S Testelin, S Boucher, R Breheret, A Gueutier, A Kahn, J KÜn-Darbois, A Barrabe, Z Lakkis, A Louvrier, S Manfredelli, P Mathieu, A Chebaro, V Drubay, M El Amrani, C Eveno, K Lecolle, G Legault, L Martin, G Piessen, F R Pruvot, S Truant, P Zerbib, Q Ballouhey, B Barrat, J Laloze, H Salle, A Taibi, J Usseglio, D Bergeat, A Merdrignac, Roy B Le, L O Perotto, A Scalabre, A Aimé, A Ezanno, B Malgras, P Bouche, S Tzedakis, E Cotte, O Glehen, V Kepenekian, J Lifante, G Passot, A D'Urso, E Felli, D Mutter, P Pessaux, B Seeliger, J Bardet, R Berry, G Boddaert, S Bonnet, E Brian, C Denet, D Fuks, D 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La Regina, F Mongelli, M Chevallay, O Dwidar, E Gialamas, M Sauvain, F Klenke, A Kollàr, C Kurze, M Adamina, T Bächler, A S Crugnale, M Giardini, L Guglielmetti, G Peros, F Solimene, A Aghayeva, I Hamzaoglu, I Sahin, E Akaydin, Z Aliyeva, E Aytac, B Baca, O DÜlgeroğlu, V Ozben, B B Ozmen, C Uras, A E Arikan, I A Bilgin, B Bozkirli, G O Ceyhan, H Kara, T Karahasanoglu, C Uras, H Celik, M M Meydanli, H Akilli, A Ayhan, E Kuscu, M A Onan, U Akgor, H A Dincer, T Erol, M Gultekin, N Orhan, N Ozgul, M C Salman, B Soyak, A Alhamed, S ErgÜn, M F OZcelik, A N Sanli, S S Uludag, M Velidedeoglu, A K Zengin, M A Bozkurt, Y Kara, A Kocatas, B Cimenoglu, R Demirhan, K Saracoglu, I F Azamat, E Balik, D Bugra, B Giray, C B Kulle, C Taskiran, D Vatansever, K Gözal, S A GÜler, H Köken, O C Tatar, N Z Utkan, A Yildirim, E YÜksel, E Akin, F Altintoprak, Z Bayhan, G Cakmak, R Çapoglu, F Çelebi, H Demir, E Dikicier, N Firat, E GönÜllÜ, M B Kamburoglu, B Kocer, I F KÜçÜk, B Mantoglu, E Çolak, G O Kucuk, M S Uyanik, B Göksoy, E Bozkurt, B Citgez, M Mihmanli, M Tanal, G Yetkin, M Akalin, C Arican, E K Avci, C Aydin, S Demirli Atici, M Emiroglu, T Kaya, E Kebabçi, G Kilinc, Y Kirmizi, H Ogucu, S Salimoglu, I Sert, C Tugmen, K Tuncer, G Uslu, D Yesilyurt, E Karaman, A Kolusari, A Yildiz, O Benson, H Lule, J Agilinko, A Ahmeidat, M Barabasz, M Bekheit, L K Cheung, T Colloc, W Cymes, M Elhusseini, G Gradinariu, A Hannah, B S Kamera, G Mignot, S Shaikh, P Sharma, I Abu-Nayla, A Agrawal, A Al-Mohammad, S Ali, J Ashcroft, A Azizi, O Baker, A Balakrishnan, M Byrne, A Colquhoun, A Cotter, P Coughlin, R J Davies, A Durrani, M Elshaer, S Fordington, P Forouhi, F Georgiades, H Grimes, A Habeeb, V Hudson, P Hutchinson, E Irune, A Jah, D Z Khan, A Kolias, H Kyriacou, B Lamb, S Liau, L Luke, R Mahmoud, R Mannion, L Masterson, C G Mitrofan, M Mohan, A Morris, S Murphy, R O'Neill, S Price, J Pushpa-Rajah, W Raby-Smith, J Ramzi, S Rooney, T Santarius, A Singh, G D Stewart, X S Tan, A Townson, E Tweedle, C Walker, S Waseem, S Yordanov, T Jones, A Kattakayam, C Loh, R Lunevicius, S Pringle, A Schache, R Shaw, A Sheel, C Rossborough, D Angelou, M Choynowski, B McAree, A McCanny, D Neely, G Tutoveanu, S Ahad, Mfi De La Cruz Monroy, F Mosley, V Oktseloglou, A Alanbuki, M Patel, A Shabana, E Perera, D Raveendran, K Ravi-Shankar, J Thiruchelvam, L Arrowsmith, W Campbell, T Grove, C Kontovounisios, O Warren, P Rolland, A Aggarwal, S Brown, C Jelley, N Neal, R Clifford, N Eardley, E Krishnan, N Manu, E Martin, S Roy Mahapatra, O L Serevina, C Smith, D Vimalachandran, M Bordenave, R Houston, G Putnam, A Robson, H Tustin, K Emslie, P L Labib, A Marchbank, D Miller, G Minto, J Natale, H Nwinee, P Panahi, L Rogers, A Abubakar, M M Akhter Rahman, E Chan, Kyk Ko, H O'Brien, K Sasapu, H Woodun, R Inglis, H J Ng, A De Gea Rico, N Ghazali, J Lambert, G Markose, S Math, I Sarantitis, D Shrestha, A Sultana, M Taggarsi, S Timbrell, O P Vaz, L Vitone, A Day, H Dent, M Fahim, S Waheed, A Hunt, N Laskar, A Gupta, J Steinke, S Thrumurthy, E Massie, K McGivern, D Rutherford, M Wilson, J Hardie, S Kazzaz, S Handa, M Kaushal, A Kler, P Patel, J Redfern, S Tezas, Y Aawsaj, S Amonkar, C Barry, L Blackwell, D Blake, J Carter, H Emerson, A Fisher, M Katory, P Korompelis, W McCormick, A Mustafa, L Pearce, N Ratnavelu, R Reehal, L Kretzmer, L Lalou, B Manku, I Parwaiz, J Stafford, M Abdelkarim, A Asqalan, T Gala, S Ibrahim, A Maw, R Mithany, R Morgan, G Sundaram Venkatesan, K Ang, E J Caruana, M F Chowdhry, A Mohammad, A Nakas, S Rathinam, M Boal, O Brown, S Dwerryhouse, S Higgs, A Vallance, E Boyd, V Irvine, A Kirk, G Bakolas, A Boulton, A Chandock, T Khan, M Kumar, P Agoston, A Bille, B Challacombe, S Fraser, K Harrison-Phipps, J King, G Mehra, L Mills, M Najdy, R Nath, L Okiror, J Pilling, V Rizzo, T Routledge, A Sayasneh, L Stroman, A Wali, M Fehervari, C Fotopoulou, N Habib, S Hamrang-Yousefi, Z Jawad, L Jiao, M Pai, J Ploski, P Rajagopal, S Saso, M Sodergren, D Spalding, S Laws, C Hardie, C McNaught, R Alam, A Budacan, J Cahill, M Kalkat, S Karandikar, L Kenyon, D Naumann, A Patel, J Ayorinde, T Chase, T Cuming, A Ghanbari, L Humphreys, S Tayeh, A Aboelkassem Ibrahim, R Bichoo, H Cao, Akw Chai, J Choudhury, C Evans, H Fitzjohn, H Ikram, M Langstroth, M Loubani, A McMillan, S Nazir, Ssa Qadri, A Robinson, E Ross, T Sehgal, A Wilkins, J Dixon, J Dunning, K Freystaetter, M Jha, S Lester, A Madhavan, S V Thulasiraman, Y Viswanath, T Curl-Roper, C Delimpalta, Ccl Liao, V Velchuru, E Westwood, E Belcher, G Bond-Smith, S Chidambaram, F Di Chiara, K Fasanmade, L Fraser, H Fu, M Ganau, S Gore, J Graystone, D Jeyaretna, H Khatkar, M Lami, M Maher, S Mastoridis, R Mihai, R Piper, S Prabhu, Obf Risk, U Selbong, K Shah, R Smillie, H Soleymani Majd, S Sravanam, D Stavroulias, G D Tebala, M Vatish, C Verberne, K Wallwork, S Winter, M I Bhatti, H Boyd-Carson, E Elsey, E Gemmill, P Herrod, M Jibreel, E Lenzi, T Saafan, D Sapre, T Sian, N Watson, A Athanasiou, G Bourke, L Bradshaw, A Brunelli, J Burke, P Coe, F Costigan, H Elkadi, M Ho, J Johnstone, A Kanatas, V Kantola, A Kaufmann, A Laios, S Lam, E MacInnes, S Munot, C Nahm, M Otify, C Pompili, I Smith, G Theophilou, G Toogood, R Wade, D Ward, C West, S Annamalai, C Ashmore, A Boddy, T Hossain, A Kourdouli, A Gvaramadze, A Jibril, L Prusty, D Thekkinkattil, A Harky, M Shackcloth, A Askari, C Chan, N Cirocchi, S Kudchadkar, K Patel, J Sagar, S Shaw, R Talwar, M Abdalla, R Edmondson, O Ismail, D Jones, K Newton, N Stylianides, A Aderombi, U Andaleeb, O Bajomo, K Beatson, W Garrett, M Mehmood, V Ng, R Al-Habsi, G S Divya, B Keeler, B Al-Sarireh, R Egan, R Harries, A Henry, M Kittur, Z Li, K Parkins, F Soliman, N Spencer, D Thompson, C Burgess, C Gemmell, C Grieco, M Hollyman, L Hunt, J Morrison, S Ojha, N Ryan, F Abbadessa, S Barnard, C Chan, N Dawe, J Hammond, Ali F Mahmoud, I McPherson, C Mellor, J Moir, S Pandanaboyana, J Powell, B Rai, A Rogers, C Roy, A Sachdeva, C Saleh, S Tingle, T Williams, J Manickavasagam, C McDonald, N McGrath, N McSorley, K Ragupathy, L Ramsay, A Solth, O Kakisi, K Seebah, I Shaikh, L Sreedharan, M Youssef, J Shah, P Ameerally, N McLarty, S Mills, A Shenfine, K Sahnan, J Abu, E Addae-Boateng, D Bratt, L Brock, N Burnside, S Cadwell-Sneath, K Gajjar, C Gan, C Grundy, K Hallam, K Hassell, M Hawari, A Joshi, H Khout, K Konstantinidi, Rxn Lee, D Nunns, R Schiemer, T Walton, H Weaver, L Whisker, K Williamson, J McVeigh, R Myatt, M A Williams, R Kaur, E Leung, S Sundar, M Michel, S Patil, S Ravindran, J Sarveswaran, L Scott, M Edmond, E King, M Almond, A Bhangu, O Breik, L D Cato, A Desai, S Ford, E Griffiths, M Idle, M Kamal, A Kisiel, R Kulkarni, Jkc Mak, T Martin, P Nankivell, A Parente, S Parmar, A M Pathanki, L Phelan, P Praveen, S Saeed, N Sharma, J Singh, F Tirotta, D Vijayan, A Geddes, J McCaul, J McMahon, A H Khan, F Khan, A Mansuri, S Mukherjee, M Patel, M Sarigul, S Singh, K L Tan, A Woodham, A Adiamah, H Brewer, A Chowdhury, J Evans, D Humes, J Jackman, A Koh, C Lewis-Lloyd, O Oyende, J Reilly, D Worku, P Cool, G Cribb, K Shepherd, C Bisset, S Moug, N Elson, G Faulkner, P Saleh, C Underwood, G Brixton, L Findlay, T Klatte, A Majkowska, J Manson, R Potter, A Bhalla, Z Chia, P Daliya, A Goyal, E Grimley, A Hamad, A Kumar, F L Malcolm, E Theophilidou, J Bowden, N Campain, I Daniels, C Evans, G Fowler, J John, L Massey, F McDermott, J McGrath, A McLennan, M Ng, J Pascoe, N Rajaretnam, S Bulathsinhala, B Davidson, G Fusai, C Hidalgo Salinas, N Machairas, T Pissanou, J M Pollok, D A Raptis, F Soggiu, H Tzerbinis, S E Xyda, A Beamish, E Davies, R Foulkes, D Magowan, H Nassa, R Ooi, C Price, L Smith, F Solari, A Tang, G Williams, Y Al-Tamimi, A Bacon, N Beasley, D Chew, M Crank, N Ilenkovan, M Macdonald, B Narice, O Rominiyi, A Thompson, I Varley, T Drake, E Harrison, G Linder, J Mayes, R McGregor, R Skipworth, V Zamvar, E Davies, P Hawkin, T Raymond, O Ryska, R Baron, D Dunne, S Gahunia, C Halloran, N Howes, R McKinney, F McNicol, J Russ, P Szatmary, J R Tan, A Thomas, P Whelan, A Anzak, A Banerjee, O Fuwa, F Hughes, J D Jayasinghe, C Knowles, H Kocher, I Leal Silva, F S Ledesma, A Minicozzi, L Navaratne, R Rahman, R Ramamoorthy, C Sohrabi, M Thaha, B Thakur, M Venn, V Yip, R Baumber, J Parry, S Evans, L Jeys, G Morris, M Parry, J Stevenson, N Ahmadi, G Aresu, Z M Barrett-Brown, A S Coonar, H Durio Yates, D Gearon, J Hogan, M King, A Peryt, I S Pradeep, C Smith, M Adishesh, R Atherton, K Baxter, M Brocklehurst, M Chaudhury, N Krishnamohan, J McAleer, G Owens, E Parkin, P Patkar, I Phang, A Aladeojebi, M Ali, B Barmayehvar, A Gaunt, M Gowda, E Halliday, M Kitchen, F Mansour, M Thomas, D Zakai, N Abbassi-Ghadi, H Assalaarachchi, A Currie, M Flavin, A Frampton, M Hague, C Hammer, J Hopper, J Horsnell, S Humphries, A Kamocka, T K Madhuri, S Preston, P Singh, J Stebbing, A Tailor, D Walker, F Aljanadi, M Jones, P Mhandu, C O'Donnell, R Turkington, Z Al-Ishaq, S Bhasin, A S Bodla, A Burahee, A Crichton, R Fossett, N Pigadas, S Pickford, E Rahman, D Snee, R Vidya, N Yassin, F Colombo, D Fountain, M T Hasan, K Karabatsou, R Laurente, O Pathmanaban, A Al-Mukhtar, S Brown, J Edwards, A Giblin, C Kelty, M Lee, G Lye, T Newman, A Sharkey, C Steele, N Sureshkumar Shah, E Whitehall, R Athwal, A Baker, L Jones, C Konstantinou, S Ramcharan, S Singh, J Vatish, R Wilkin, M Ethunandan, G K Sekhon, H Shields, R Singh, F Wensley, S Lawday, A Lyons, T Abbott, S Anwar, K Ghufoor, C Sohrabi, E Chung, R Hagger, A Hainsworth, A Karim, H Owen, A Ramwell, K Williams, C Baker, A Davies, J Gossage, M Kelly, W Knight, J Hall, G Harris, G James, C Kang, D J Lin, A D Rajgor, T Royle, R Scurrah, B Steel, L J Watson, D Choi, R Hutchison, A Jain, V Luoma, H Marcus, R May, A Menon, B Pramodana, L Webber, I A Aneke, P Asaad, B Brown, J Collis, S Duff, A Khan, F Moura, B Wadham, H Warburton, T Elmoslemany, M Jenkinson, C Millward, R Zakaria, S Mccluney, C Parmar, S Shah, J Allison, M S Babar, B Collard, S Goodrum, K Lau, A Patel, R Scott, E Thomas, H Whitmore, D Balasubramaniam, B Jayasankar, S Kapoor, A Ramachandran, A Elhamshary, Smb Imam, K Kapriniotis, V Kasivisvanathan, J Lindsay, S Rakhshani-Moghadam, N Beech, M Chand, L Green, N Kalavrezos, H Kiconco, R McEwen, C Schilling, D Sinha, J Pereca, J Singh, S Chopra, D Egbeare, R Thomas, T Combellack, Sef Jones, M Kornaszewska, M Mohammed, A Sharma, G Tahhan, V Valtzoglou, J Williams, P Eskander, K Gash, L Gourbault, M Hanna, T Maccabe, C Newton, J Olivier, S Rozwadowski, E Teh, D West, H Al-Omishy, M Baig, H Bates, G Di Taranto, K Dickson, N Dunne, C Gill, D Howe, D Jeevan, A Khajuria, K Martin-Ucar AMcEvoy, P Naredla, V Ng, S Robertson, M Sait, D R Sarma, S Shanbhag, T Shortland, S Simmonds, J Skillman, N Tewari, G Walton, M A Akhtar, A Brunt, J McIntyre, K Milne, M M Rashid, A Sgro, K E Stewart, A Turnbull, M Aguilar Gonzalez, S Talukder, C Boyle, D Fernando, K Gallagher, A Laird, D Tham, M Bath, P Patki, C Sohrabi, C Tanabalan, T Arif, C Magee, T Nambirajan, S Powell, R Vinayagam, I Flindall, A Hanson, V Mahendran, S Green, M Lim, L MacDonald, V Miu, L Onos, K Sheridan, R Young, F Alam, O Griffiths, C Houlden, R Jones, V S Kolli, A K Lala, S Leeson, R Peevor, Z Seymour, L Chen, E Henderson, A Loehrer, K Brown, D Fleming, A Haynes, C Heron, C Hill, H Kay, E Leede, K McElhinney, K Olson, E C Osterberg, C Riley, P Srikanth, M Thornhill, D Blazer, G DiLalla, E S Hwang, W Lee, M Lidsky, J Plichta, L Rosenberger, R Scheri, K Shah, K Turnage, J Visgauss, S Zani, J Farma, J Clark, D Kwon, E Etchill, H E Gabre-Kidan AJenny, A Kent, M Ladd, C Long, H Malapati, A Margalit, S Rapaport, J Rose, K Stevens, L Tsai, D Vervoort, P Yesantharao, A Dehal, D Klaristenfeld, K Huynh, L Brown, I Ganly, J Mullinax, N Gusani, J Hazelton, J Maines, J S Oh, A Ssentongo, P Ssentongo, M Azam, A Choudhry, W Marx, J Fleming, A Fuson, J Gigliotti, A Ovaitt, Y Ying, M K Abel, V Andaya, K Bigay, M A Boeck, L Chen, H Chern, C Corvera, I El-Sayed, A Glencer, P Ha, Bcs Hamilton, C Heaton, K Hirose, D M Jablons, K Kirkwood, L Z Kornblith, J R Kratz, R Lee, P N Miller, E Nakakura, B Nunez-Garcia, R O'Donnell, D Ozgediz, P Park, B Robinson, A Sarin, B Sheu, M Varma, K Wai, R Wustrack, M J Xu, D Beswick, J Goddard, J Manor, J Song, T Fullmer, C Gaskill, N Gross, K Kiong, C L Roland, S N Zafar, M Abdallah, A Abouassi, M Almasri, G Kulkarni, H Marwan, M Mehdi, S Aoun, V S Ban, H H Batjer, J Caruso, D Abbott, A Acher, T Aiken, J Barrett, E Foley, P Schwartz, S N Zafar, A Hawkins, A Maiga, J Laufer, S Scasso
Subjects: Aged, 80 and over, Male, Critical Care, SARS-CoV-2, International Cooperation, COVID-19, Middle Aged, Cohort Studies, Logistic Models, Postoperative Complications, Elective Surgical Procedures, Neoplasms, Outcome Assessment, Health Care, Humans, Female, Epidemics, Aged
Abstract: PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.
Published: 2021

194. Protein production by Escherichiacoli wild-type and ΔptsG mutant strains with IPTG induction at the onset

Author: Picon, A., de Mattos, M. J. Teixeira, and Postma, P. W.
Published: 2008
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195. Dynamic cerebral autoregulation changes during sub-maximal handgrip maneuver.

Author: Ricardo C Nogueira, Edson Bor-Seng-Shu, Marcelo R Santos, Carlos E Negrão, Manoel J Teixeira, and Ronney B Panerai
Subjects: Medicine, Science
Abstract: PURPOSE: We investigated the effect of handgrip (HG) maneuver on time-varying estimates of dynamic cerebral autoregulation (CA) using the autoregressive moving average technique. METHODS: Twelve healthy subjects were recruited to perform HG maneuver during 3 minutes with 30% of maximum contraction force. Cerebral blood flow velocity, end-tidal CO₂ pressure (PETCO₂), and noninvasive arterial blood pressure (ABP) were continuously recorded during baseline, HG and recovery. Critical closing pressure (CrCP), resistance area-product (RAP), and time-varying autoregulation index (ARI) were obtained. RESULTS: PETCO₂ did not show significant changes during HG maneuver. Whilst ABP increased continuously during the maneuver, to 27% above its baseline value, CBFV raised to a plateau approximately 15% above baseline. This was sustained by a parallel increase in RAP, suggestive of myogenic vasoconstriction, and a reduction in CrCP that could be associated with metabolic vasodilation. The time-varying ARI index dropped at the beginning and end of the maneuver (p
Published: 2013
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196. DBS for Obesity

Author: Ruth Franco, Erich T. Fonoff, Pedro Alvarenga, Antonio Carlos Lopes, Euripides C. Miguel, Manoel J. Teixeira, Durval Damiani, and Clement Hamani
Subjects: deep brain stimulation, obesity, hypothalamus, nucleus accumbens, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract: Obesity is a chronic, progressive and prevalent disorder. Morbid obesity, in particular, is associated with numerous comorbidities and early mortality. In patients with morbid obesity, pharmacological and behavioral approaches often have limited results. Bariatric surgery is quite effective but is associated with operative failures and a non-negligible incidence of side effects. In the last decades, deep brain stimulation (DBS) has been investigated as a neurosurgical modality to treat various neuropsychiatric disorders. In this article we review the rationale for selecting different brain targets, surgical results and future perspectives for the use of DBS in medically refractory obesity.
Published: 2016
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197. EVALUATION OF A LARYNGEAL MASK AIRWAY AS AN ALTERNATIVE TO OROTRACHEAL INTUBATION FOR MAINTAINING AIRWAY PATENCY DURING INHALANT ANESTHESIA UNDER SPONTANEOUS VENTILATION IN CAPYBARAS (

Author: Carolina H, Girotto, Francisco J, Teixeira-Neto, André A, Justo, Elizabeth R, Carvalho, Mariana W, Fonseca, and Natache A, Garofalo
Subjects: Isoflurane, Anesthetics, Inhalation, Intubation, Intratracheal, Animals, Rodentia, Anesthesia, Inhalation, Laryngeal Masks
Abstract: Orotracheal intubation carries greater difficulty in rodents than in most domestic species. The human laryngeal mask airway (LMA) was compared with an endotracheal tube (ET
Published: 2020

198. Comparative Study of the Effectiveness of Lumboperitoneal and Ventriculoperitoneal Shunting with Neuronavigation in the Treatment of Idiopathic Intracranial Hypertension

Author: Adilson J M, de Oliveira, Fernando C G, Pinto, and Manoel J, Teixeira
Subjects: Male, Pseudotumor Cerebri, Treatment Outcome, Humans, Female, Intracranial Hypertension, Ventriculoperitoneal Shunt, Neuronavigation, Retrospective Studies
Abstract: Idiopathic intracranial hypertension is an uncommon intracranial disorder in which intracranial pressure is increased without radiological evidence of lesions. Surgery is indicated when severe optic neuropathy is present or medical treatment fails.To assess the comparative effectiveness of lumboperitoneal (LPS) and ventriculoperitoneal shunt (VPS) with neuronavigation.A retrospective study was performed based on our database. We analyzed demographics, pre and postoperative parameters, and follow-up data on patients who had undergone either LPS or VPS between January 2007 and December 2017.Group I consisted of 17 VPS patients, of which 16 were female, and group II consisted of 29 LPS patients, of which 26 were female. The number of surgeries performed in the LPS group was higher (due to recurrence) than that in the VPS group. Moreover, the rate of complications was higher in the LPS group.VPS is safer and has a lower rate of complications and reinterventions compared to LPS.
Published: 2020

199. A Theory- and Evidence-Based Digital Intervention Tool for Weight Loss Maintenance (NoHoW Toolkit): Systematic Development and Refinement Study (Preprint)

Author: Marta M Marques, Marcela Matos, Elina Mattila, Jorge Encantado, Cristiana Duarte, Pedro J Teixeira, R James Stubbs, Falko F Sniehotta, Miikka Ermes, Marja Harjumaa, Juha Leppänen, Pasi Välkkynen, Marlene N Silva, Cláudia Ferreira, Sérgio Carvalho, Lara Palmeira, Graham Horgan, Berit Lilienthal Heitmann, Elizabeth H Evans, and António L Palmeira
Abstract: BACKGROUND Many weight loss programs show short-term effectiveness, but subsequent weight loss maintenance is difficult to achieve. Digital technologies offer a promising means of delivering behavior change approaches at low costs and on a wide scale. The Navigating to a Healthy Weight (NoHoW) project, which was funded by the European Union’s Horizon 2020 research and innovation program, aimed to develop, test, and evaluate a digital toolkit designed to promote successful long-term weight management. The toolkit was tested in an 18-month, large-scale, international, 2×2 factorial (motivation and self-regulation vs emotion regulation) randomized controlled trial that was conducted on adults with overweight or obesity who lost ≥5% of their body weight in the preceding 12 months before enrollment into the intervention. OBJECTIVE This paper aims to describe the development of the NoHoW Toolkit, focusing on the logic models, content, and specifications, as well as the results from user testing. METHODS The toolkit was developed by using a systematic approach, which included the development of the theory-based logic models, the selection of behavior change techniques, the translation of these techniques into a web-based app (NoHoW Toolkit components), technical development, and the user evaluation and refinement of the toolkit. RESULTS The toolkit included a set of web-based tools and inputs from digital tracking devices (smart scales and activity trackers) and modules that targeted weight, physical activity, and dietary behaviors. The final toolkit comprised 34 sessions that were distributed through 15 modules and provided active content over a 4-month period. The motivation and self-regulation arm consisted of 8 modules (17 sessions), the emotion regulation arm was presented with 7 modules (17 sessions), and the combined arm received the full toolkit (15 modules; 34 sessions). The sessions included a range of implementations, such as videos, testimonies, and questionnaires. Furthermore, the toolkit contained 5 specific data tiles for monitoring weight, steps, healthy eating, mood, and sleep. CONCLUSIONS A systematic approach to the development of digital solutions based on theory, evidence, and user testing may significantly contribute to the advancement of the science of behavior change and improve current solutions for sustained weight management. Testing the toolkit by using a 2×2 design provided a unique opportunity to examine the effect of motivation and self-regulation and emotion regulation separately, as well as the effect of their interaction in weight loss maintenance.
Published: 2020
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200. NoHoW Toolkit Development

Author: Marta M Marques, Marcela Matos, Elina Mattila, Jorge Encantado, Cristiana Duarte, Pedro J. Teixeira, James Stubbs, Falko Sniehotta, Miikka Ermes, null marja.harjumaa, Juha Leppänen, Pasi valkkynen, Marlene N. Silva, Claudia Ferreira, Sérgio Carvalho, Lara Palmeira, Graham Horgan, Berit L. Heitmann, Elizabeth H. Evans, and António L Palmeira
Subjects: Engineering, Text mining, Development (topology), business.industry, business, Data science
Abstract: Background: Many weight loss programs show short-term effectiveness, but subsequent weight loss maintenance is difficult to achieve. Digital technologies offer promising means to delivering behaviour change approaches at low cost and on a wide scale. The NoHoW project was a European Commission H2020-funded project aimed to develop, test, and evaluate a digital Toolkit designed to promote successful long-term weight management. The Toolkit was tested in an 18-month large-scale international 2 x 2 factorial (motivation and self-regulation versus emotion regulation) randomised controlled trial, conducted in overweight/obese adults who lost ≥5% of their body weight in the preceding twelve months before enrolment into the intervention. Objective: This paper describes the development of the NoHoW Toolkit focusing on the logic models, content and specifications, and results from user testing.Methods: The Toolkit was developed using a systematic approach including (1) development of the theory-based logic models, (2) selection of behaviour change techniques, (3) translation of these techniques into a digital web-based app (NoHoW Toolkit components), (4) technical development, (5) user evaluation and refinement of the Toolkit.Results: The Toolkit included a set of web-based tools and inputs from digital tracking devices (smart scales and activity trackers), with modules targeting weight, physical activity, and dietary behaviours. The final Toolkit was comprised of 34 sessions, distributed through 15 modules, providing active content over a 4-month period. The motivation and self-regulation arm consisted of 8 modules (17 sessions), the emotion regulation arm was presented with 7 modules (17 sessions), and the combined arm received the full Toolkit (15 modules, 34 sessions). The sessions included a range of implementations, such as videos, testimonies, and questionnaires. Further, the Toolkit contained 5 specific data tiles for monitoring weight, steps, healthy eating, mood and sleep. Conclusions: A systematic approach to the development of digital solutions based on theory, evidence, and user testing, may significantly contribute to the advancement of the science of behaviour change and improve current solutions for sustained weight management. Testing the Toolkit using a 2x2 design provided a unique opportunity to examine the effect of motivation and self-regulation and emotion regulation separately, as well as the effect of their interaction in weight loss maintenance.
Published: 2020
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