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1,693 results on '"Ito, Seiji"'

151. Risk Prediction for Gastric Cancer Using GWAS-Identifie Polymorphisms, Helicobacter pylori Infection and Lifestyle-Related Risk Factors in a Japanese Population

Author

Ishikura, Naoyo, primary, Ito, Hidemi, additional, Oze, Isao, additional, Koyanagi, Yuriko N., additional, Kasugai, Yumiko, additional, Taniyama, Yukari, additional, Kawakatsu, Yukino, additional, Tanaka, Tsutomu, additional, Ito, Seiji, additional, Tajika, Masahiro, additional, Shimizu, Yasuhiro, additional, Niwa, Yasumasa, additional, and Matsuo, Keitaro, additional

Published
2021
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152. ASO Visual Abstract: Significance of Antimicrobial Prophylaxis for Prevention of Early-Onset Pneumonia after Radical Esophageal Cancer Resection: A Retrospective Analysis of 356 Patients Undergoing Thoracoscopic Esophagectomy

Author

Higaki, Eiji, primary, Abe, Tetsuya, additional, Fujieda, Hironori, additional, Hosoi, Takahiro, additional, Nagao, Takuya, additional, Komori, Koji, additional, Ito, Seiji, additional, Itoh, Naoya, additional, Matsuo, Keitaro, additional, and Shimizu, Yasuhiro, additional

Published
2021
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153. E-PASS scoring system serves as a predictor of short- and long-term outcomes in gastric cancer surgery

Author

Nakanishi, Koki, primary, Kanda, Mitsuro, additional, Ito, Seiji, additional, Mochizuki, Yoshinari, additional, Teramoto, Hitoshi, additional, Ishigure, Kiyoshi, additional, Murai, Toshifumi, additional, Asada, Takahiro, additional, Ishiyama, Akiharu, additional, Matsushita, Hidenobu, additional, Kobayashi, Daisuke, additional, Shimizu, Dai, additional, Tanaka, Chie, additional, Fujiwara, Michitaka, additional, Murotani, Kenta, additional, and Kodera, Yasuhiro, additional

Published
2021
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154. Ileal conduit necrosis after total pelvic exenteration for recurrence of gastrointestinal stromal tumor

Author

Komori, Koji, Okuno, Nozumi, Kinoshita, Takashi, Oshiro, Taihei, Ouchi, Akira, Ito, Seiji, Abe, Tetsuya, Senda, Yoshiki, Misawa, Kazunari, Ito, Yuichi, Uemura, Norihisa, Natsume, Seiji, Higaki, Eigi, Okuno, Masataka, Hosoi, Takahiro, An, Byonggu, Hayashi, Daisuke, Uchino, Tairin, Kunitomo, Aina, Oki, Satoshi, Takano, Jin, Suenaga, Yasuhito, Maeda, Shingo, Dei, Hideyuki, Numata, Yoshihisa, and Shimizu, Yasuhiro

Subjects
ileal conduit necrosis, total pelvic exenteration, digestive system
Abstract

We report a case of ileal conduit necrosis after total pelvic exenteration for recurrence of gastrointestinal stromal tumor. A 47-year-old man was diagnosed with recurrence of gastrointestinal stromal tumor adjacent to the prostate after abdominoperineal resection 10 years prior. With imatinib administration for 18 months, the local recurrence decreased in size but did not separate from the prostate. We performed urinary diversion with conventional total pelvic exenteration. Ileal conduit necrosis was suspected the following day and emergency surgery was performed. The serosa of the ileal conduit showed segmental necrosis extending about 10 cm from the orifice. The ureterointestinal anastomotic site was opposite the orifice and was not necrotic. We resected the necrotic ileum and reconstructed an ileal conduit. The patient was discharged without any symptoms 46 days after surgery for further adjustment to use of a urostomy.

Published
2019

155. A long-term survival case of Sister Mary Joseph’s nodule caused by colon cancer and treated with a multidisciplinary approach

Author

Iwata, Yoshinori, Kinoshita, Takashi, Kimura, Kenya, Komori, Koji, Hayashi, Daisuke, Akazawa, Tomoyuki, Shigeyoshi, Itaru, Tsutsuyama, Masayuki, Kawakami, Jiro, Ouchi, Akira, Natsume, Seiji, Uemura, Norihisa, Ito, Yuichi, Misawa, Kazunari, Senda, Yoshiki, Abe, Tetsuya, Ito, Seiji, Tajika, Masahiro, Yatabe, Yasushi, Yoshida, Kazuhiro, and Shimizu, Yasuhiro

Subjects
colon cancer, Sister Mary Joseph’s nodule, multidisciplinary treatment, umbilical metastasis
Abstract

Umbilical metastasis from intra-abdominal or pelvic malignancy, which is called Sister Mary Joseph’s nodule (SMJN), is rare, and it has a poor prognosis. Its most common primary sites are the stomach and ovaries. SMJN caused by colon cancer is uncommon. A 42-year-old woman visited local clinics with complaints of an umbilical mass. After a detailed examination, she was diagnosed with peritoneal and umbilical metastasis caused by colon cancer. A radical surgery was performed after 12 months of chemotherapy. 6 months later, local recurrence and ovarian metastasis were suspected. Further radical surgery was performed, and 14 months after that (50 months after starting treatment), no recurrences have been observed. We experienced a long-term survival case of SMJN caused by colon cancer and treated with a multidisciplinary approach.

Published
2019

156. Tegafur and 5-fluorouracil levels in tears and changes in tear volume in long-term users of the oral anticancer drug S-1

Author

Kuriki, Reiko, Hata, Tsuyoshi, Nakayama, Kinuyo, Ito, Yuichi, Misawa, Kazunari, Ito, Seiji, Tatematsu, Michiko, and Kaneda, Norio

Subjects
Adult, Aged, 80 and over, Male, Original Paper, watering eyes, Administration, Oral, S-1, Middle Aged, eye diseases, Drug Combinations, Oxonic Acid, Tandem Mass Spectrometry, Tears, Quality of Life, tegafur, Humans, 5-fluorouracil, Female, sense organs, Fluorouracil, LC-MS/MS, Aged, Chromatography, Liquid
Abstract

Eye problems are an adverse reaction sometimes found in chemotherapy. Although not life-threatening, they can reduce patients’ quality of life. The highest incidence of eye problems is reported for the combination anticancer drug S-1 (tegafur–gimeracil–oteracil), and methods to prevent or treat the eye problems caused by this drug are presently lacking. To determine early detection methods and treatment for adverse ocular reactions, we measured changes in tear volume and levels of tegafur (FT) and 5-fluorouracil (5-FU), an active metabolite of FT, in the tears of patients with long-term use of S-1. A total of 11 patients receiving S-1 monotherapy as adjuvant chemotherapy after gastric cancer surgery were included. Tear volume and FT and 5-FU levels in tears were measured by liquid chromatography with tandem mass spectrometry during a maximum of 8 treatment cycles (48 weeks). For analysis, patients were divided into two groups: “watering eyes” (n=6, complaints of watering eyes at least once during the treatment period) and “no watering eyes” (n=5, no complaints of watering eyes). Both groups exhibited increased FT and 5-FU levels in tears upon initiation of S-1 treatment, and levels rapidly decreased upon discontinuation. Our findings suggest a relationship between FT level in tears and tear volume in patients with long-term S-1 use. The symptom of watering eyes may thus be linked to FT level in tears.

Published
2019

170. Significance of Antimicrobial Prophylaxis for the Prevention of Early-Onset Pneumonia After Radical Esophageal Cancer Resection: A Retrospective Analysis of 356 Patients Undergoing Thoracoscopic Esophagectomy

Author

Higaki, Eiji, primary, Abe, Tetsuya, additional, Fujieda, Hironori, additional, Hosoi, Takahiro, additional, Nagao, Takuya, additional, Komori, Koji, additional, Ito, Seiji, additional, Itoh, Naoya, additional, Matsuo, Keitaro, additional, and Shimizu, Yasuhiro, additional

Published
2021
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172. Prognostic impact of a microscopic positive margin in patients undergoing gastrectomy for gastric cancer: a propensity score‑matched analysis of a multi‑institutional dataset

Author

Nakanishi, Koki, primary, Kanda, Mitsuro, additional, Ito, Seiji, additional, Mochizuki, Yoshinari, additional, Teramoto, Hitoshi, additional, Ishigure, Kiyoshi, additional, Murai, Toshifumi, additional, Asada, Takahiro, additional, Ishiyama, Akiharu, additional, Matsushita, Hidenobu, additional, Shimizu, Dai, additional, Tanaka, Chie, additional, Fujiwara, Michitaka, additional, Murotani, Kenta, additional, and Kodera, Yasuhiro, additional

Published
2021
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188. Risk factors for recurrence in each pattern after curative gastrectomy for pStage II/III gastric cancer: An exploratory analysis of a randomized controlled trial (JCOG1001).

Author

Toriumi, Tetsuro, primary, Terashima, Masanori, additional, Mizusawa, Junki, additional, Sato, Yuya, additional, Kurokawa, Yukinori, additional, Takiguchi, Shuji, additional, Doki, Yuichiro, additional, Kawachi, Yasuyuki, additional, Shinohara, Hisashi, additional, Choda, Yasuhiro, additional, Ito, Seiji, additional, Yoshikawa, Takaki, additional, Sano, Takeshi, additional, and Sasako, Mitsuru, additional

Published
2021
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189. Neoadjuvant nivolumab monotherapy in patients with resectable gastric cancer: Preliminary results from a multicenter study.

Author

Takiguchi, Shuji, primary, Shitara, Kohei, additional, Takiguchi, Noriaki, additional, Ito, Seiji, additional, Kochi, Mitsugu, additional, Horinouchi, Hidehito, additional, Kinoshita, Takahiro, additional, Muro, Kei, additional, Yoshikawa, Takaki, additional, Hasegawa, Hirotaka, additional, Nishikawa, Hiroyoshi, additional, and Kodera, Yasuhiro, additional

Published
2021
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198. Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells

Author

Kaneko, Shiho, Okuda-Ashitaka, Emiko, Ando, Akira, Nishimura, Kazuhiro, Igarashi, Kazuei, Maeda, Masahide, Furuta, Kyoji, Suzuki, Masaaki, Matsumura, Miyo, and Ito, Seiji

Subjects
Retinal pigment epithelium -- Chemical properties, Retinal pigment epithelium -- Genetic aspects, Polyamines -- Physiological aspects, Polyamines -- Genetic aspects, Messenger RNA -- Chemical properties, Messenger RNA -- Physiological aspects, Ornithine decarboxylase -- Physiological aspects, Carrier proteins -- Physiological aspects, Carrier proteins -- Genetic aspects, Biological sciences
Abstract

We previously showed that ornithine was mainly transported via cationic amino acid transporter (CAT)-1 in human retinal pigment epithelial (RPE) cell line, human telomerase RT (hTERT)-RPE, and that CAT-1 was involved in ornithine cytotoxicity in ornithine-[delta]-aminotransferase (OAT)-deficient cell produced by a OAT specific inhibitor, 5-fluoromethylomithine (5-FMO). We showed here that CAT-1 mRNA expression was increased by ornithne in OAT-deficient RPE cells, which was reversed by an inhibitor of ornithine decarboxylase (ODC), [alpha]-difluoromethylornithine (DFMO). Polyamines, especially spermine, one of the metabolites of ODC, also enhanced the expression of CAT-1 mRNA. ODC mRNA expression was also increased by ornithine and polyamines, and gene silencing of ODC by siRNA decreased ornithine transport activity and its cytotoxicity. In addition, the mRNA of nuclear protein c-myc was also increased in 5-FMO- and ornithine-treated hTERT-RPE cells, and gene silencing of c-myc prevented the induction of CAT-1 and ODC. Increases in expression of CAT-1, ODC, and c-myc, and the inhibition of these stimulated expression by DFMO were also observed in primary porcine RPE cells. These results suggest that spermine plays an important role in stimulation of mRNA expression of CAT-l, which is a crucial role in ornithine cytotoxicity in OAT-deficient hTERT-RPE cells. ornithine transport; ornithine decarboxylase; c-myc

Published
2007

199. Senescence in cultured trabecular meshwork cells

Author

Yamazaki, Yukari, Matsunaga, Hiroshi, Nishikawa, Maki, Ando, Akira, Kaneko, Shiho, Okuda, Koji, Wada, Mitsumasa, Ito, Seiji, and Matsumura, Miyo

Subjects
Aging -- Physiological aspects, Aging -- Research, Macular degeneration -- Development and progression, Macular degeneration -- Research, Health
Published
2007

200. Mechanical allodynia in mice with tenascin-X deficiency associated with Ehlers-Danlos syndrome

Author

Okuda-Ashitaka, Emiko, Kakuchi, Yuka, Kakumoto , Hiroaki, Yamanishi , Shota, Kamada, Hiroki, Yoshidu, Takafumi, Matsukawa , Satoshi, Ogura, Naoya, Uto , Sadahito, Minami, Toshiaki, Ito, Seiji, MATSUMOTO, Kenichi, Okuda-Ashitaka, Emiko, Kakuchi, Yuka, Kakumoto , Hiroaki, Yamanishi , Shota, Kamada, Hiroki, Yoshidu, Takafumi, Matsukawa , Satoshi, Ogura, Naoya, Uto , Sadahito, Minami, Toshiaki, Ito, Seiji, and MATSUMOTO, Kenichi

Published
2020

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