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312 results on '"Iacovacci P"'

151. The EAS-TOP atmospheric-Čerenkov-light telescope and its combined operation with the e.m. Detector

Author

Aglietta, M., Alessandro, B., Antonioli, P., Arneodo, F., Bergamasco, L., Castagnoli, C., Castellina, A., Chiavassa, A., Cini, G., D'Ettorre Piazzoli, B., Di Sciascio, G., Fulgione, W., Galeotti, P., Ghia, P. L., Iacovacci, M., Mannocchi, G., Morello, C., Navarra, G., Riccati, L., Saavedra, O., Trinchero, G. C., Vallania, P., and Vernetto, S.

Published
1993
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153. First observation of high-energy cosmic-ray events obtained in coincidence between EAS-TOP and LVD at Gran Sasso

Author

Aglietta, M., Alpat, B., Alyea, E. D., Alessandro, B., Antonioli, P., Anzivino, G., Arneodo, F., Badino, G., Ban, Y., Bari, G., Basile, M., Bellagamba, L., Benelli, A., Berezinsky, V. S., Bergamasco, L., Bianco, S., Bizzetti, A., Bruni, G., Campos Fauth, A., Cao, Y., Cara Romeo, G., Casaccia, R., Castagnoli, C., Castellina, A., Cattadori, C., Chen, K., Chen, R., Chinellato, J. A., Chiavassa, A., Cifarelli, L., Cini, G., Cong, S., Contin, A., Dadikin, V. L., Dardo, M., De Silva, A., D’Ettorre Piazzoli, B., Deutsch, M., Di Sciascio, G., Dos Santos, L. G., Enikeev, R. I., Fabbri, F. L., Fulgione, W., Galeotti, P., Ghia, P. L., Giusti, P., Grianti, F., Gu, S., Hafen, E. S., Haridas, P., Iacobucci, G., Iacovacci, M., Inoue, N., Khalchukov, F. F., Korolkova, E. V., Kortchaguin, P. V., Kortchaguin, V. B., Kudryavtsev, V. A., Landi, G., Lau, K., Lin, X., Lu, L., Ma, J., Ma, Z., Maccarrone, G., Malguin, A. S., Mannocchi, G., Mao, Z., Margotti, A., Markov, M. A., Massam, T., Mayes, B., Mengotti Silva, N., Misaki, A., Mo, G. H., Monteleoni, B., Morello, C., Moromisato, J., Nania, R., Navarra, G., Panaro, L., Parks, D., Pelfer, P. G., Periale, L., Picchi, P., Pinna, P., Pinsky, L., Pless, I. A., Pu, M., Pyrlyk, J., Qiu, J., Riccati, L., Ryasny, V. G., Ryazhskaya, O. G., Saavedra, O., Saitoh, K., Sanders, D., Sartorelli, G., Sarwar, S., Shen, D., Talochkin, V. P., Tang, H., Tang, J., Tian, W., Trinchero, G. C., Turtelli, A., Uman, I., Vallania, P., Vernetto, S., von Goeler, E., Votano, L., Wada, T., Wang, F., Wang, H., Wang, S., Weathers, R., Weinstein, R., Widgoff, M., Xu, L., Xu, Z., Yakushev, V. F., Yamamoto, I., Yi, G., Zallo, A., Zatsepin, G. T., Zhou, X., Zhu, Q., Zhu, X., Zhuan, B., Zichichi, A., and EAS-TOP and LVD Collaborations

Published
1992
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154. EAS Cherenkov at Gran Sasso: correlated observations at the surface and with deep underground events

Author

Aglietta, M., Alessandro, B., Antonioli, P., Arneodo, F., Bergamasco, L., Campos Fauth, A., Castagnoli, C., Castellina, A., Cattadori, C., Chiavassa, A., Cini, G., D’Ettorre Piazzoli, B., Di Sciascio, G., Fulgione, W., Galeotti, P., Ghia, P. L., Iacovacci, M., Mannocchi, G., Morello, C., Navarra, G., Riccati, L., Saavedra, O., Trinchero, G. C., Vallania, P., Vernetto, S., and EAS-TOP Collaboration

Published
1992
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155. An experimental study of the processγγ→π + π −

Author

Behrend, H. -J., Criegee, L., Field, J. H., Franke, G., Jung, H., Meyer, J., Peters, J. H., Podobrin, O., Schröder, V., Winter, G. G., Bussey, P. J., Campbell, A. J., Hendry, D., Lumsdon, S. J., Skillicorn, I. O., Ahme, J., Blobel, V., Feindt, M., Fenner, H., Harjes, J., Köhne, J. H., Spitzer, H., Weihrich, T., Apel, W. -D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gamerdinger, K., Grosse-Wiesmann, P., Küster, H., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, C., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Journé, V., Le Diberder, L., Veillet, J. -J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., D'Agostini, G., Ferrarotto, F., Iacovacci, M., Shooshtari, G. H. B., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and CELLO Collaboration

Published
1992
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156. A measurement of the π0, η and η′ electromagnetic form factors

Author

Behrend, H.-J., Criegee, L., Field, J. H., Franke, G., Jung, H., Meyer, J., Podobrin, O., Schröder, V., Winter, G. G., Bussey, P. J., Campbell, A. J., Hendry, D., Lumsdon, S. J., Skillicorn, I. O., Ahme, J., Blobel, V., Feindt, M., Fenner, H., Harjes, J., Köhne, J. H., Peters, J. H., Spitzer, H., Weihrich, T., Apel, W.-D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gamerdinger, K., Grosse-Wiesmann, P., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, C., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Journé, V., Le Diberder, F., Veillet, J.-J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., d'Agostini, G., Ferrarotto, F., Iacovacci, M., Shooshtari, G., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and CELLO Collaboration

Published
1991
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157. Studies of multihadronic final states in photon-photon interactions

Author

Behrend, H. -J., Criegee, L., Field, J. H., Franke, G., Jung, H., Meyer, J., Podobrin, O., Schröder, V., Winter, G. G., Bussey, P. J., Campbell, A. J., Hendry, D., Lumsdon, S. J., Skillicorn, I. O., Ahme, J., Blobel, V., Feindt, M., Fenner, H., Harjes, J., Köhne, J. H., Peters, J. H., Spitzer, H., Weihrich, T., Apel, W. -D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gamerdinger, K., Grosse-Wiesmann, P., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, C., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Journé, V., Le Diberder, F., Veillet, J. -J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., d'Agostini, G., Ferrarotto, F., Iacovacci, M., Shooshtari, G., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and CELLO Collaboration

Published
1991
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158. Limits on electron compositeness from Bhabha scattering

Author

Behrend, H. J., Criegee, L., Field, J. H., Franke, G., Jung, H., Meyer, J., Podobrin, O., Schröder, V., Winter, G. G., Bussey, P. J., Campbell, A. J., Hendry, D., Lumsdon, S., Skillicorn, I. O., Ahme, J., Blobel, V., Feindt, M., Fenner, H., Harjes, J., Köhne, J., Peters, J. H., Spitzer, H., Weihrich, T., Apel, W. D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gamerdinger, K., Grosse-Wiesmann, P., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, C., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Journé, V., Le Diberder, F., Veillet, J. J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., d'Agostini, G., Ferrarotto, F., Iacovacci, M., Shooshtari, G., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and CELLO Collaboration

Published
1991
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159. A search for substructure of leptons and quarks with the CELLO detector

Author

Behrend, H. J., Criegee, L., Field, J. H., Franke, G., Jung, H., Meyer, J., Podobrin, O., Schröder, V., Winter, G. G., Bussey, P. J., Buttar, C., Campbell, A. J., Hendry, D., Lumsdon, S., Skillicorn, I. O., Ahme, J., Blobel, V., Feindt, M., Fenner, H., Harjes, J., Köhne, J., Peters, J. H., Spitzer, H., Weihrich, T., Apel, W. D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gamerdinger, K., Grosse-Wiesmann, P., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, C., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Journé, V., Le Diberder, F., Veillet, J. J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., d'Agostini, G., Ferrarotto, F., Iacovacci, M., Shooshtari, G., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and CELLO Collaboration

Published
1991
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160. ρ0 production the reaction ξξ→3π+3π−ξξ→ρ0ρ0(1700)

Author

Behrend, H. -J., Criegee, L., Field, J. H., Franke, G., Jung, H., Meyer, J., Podobrin, O., Schröder, V., Winter, G. G., Bussey, P. J., Campbell, A. J., Hendry, D., Lumsdon, S., Skillicorn, I. O., Ahme, J., Blobel, V., Brehm, W., Feindt, M., Fenner, H., Harjes, J., Köhne, J. H., Peters, J. H., Spitzer, H., Apel, W. -D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gabriel, P., Gamerdinger, K., Grosse-Wiesmann, P., Hahn, M., Hädinger, U., Hansmeyer, J., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., Seufert, R., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, C., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Journé, V., Kim, D. W., Le Diberder, F., Veillet, J. -J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., d'Agostini, G., Ferrarotto, F., Iacovacci, M., Shooshtari, G., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and CELLO Collaboration

Published
1991
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161. Exclusive τ decays with the CELLO detector at PETRA

Author

Behrend, H. J., Criegee, L., Field, J. H., Franke, G., Jung, H., Meyer, J., Podobrin, O., Schröder, V., Winter, G. G., Bussey, P. J., Campbell, A. J., Hendry, D., Lumsdon, S., Skillicorn, I. O., Ahme, J., Blobel, V., Brehm, W., Feindt, M., Fenner, H., Harjes, J., Köhne, J., Peters, J. H., Spitzer, H., Apel, W. D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gabriel, P., Gamerdinger, K., Grosse-Wiesmann, P., Hahn, M., Hädinger, U., Hansmeyer, J., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., Seufert, R., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, C., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Journé, V., Kim, D. W., Le Diberder, F., Veillet, J. J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., d'Agostini, G., Ferrarotto, F., Iacovacci, M., Shooshtari, G., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and CELLO Collaboration

Published
1990
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162. a 2(1320) andπ 2(1670) formation in the reactionγγ→π + π − π 0

Author

Behrend, H. -J., Criegee, L., Field, J. H., Franke, G., Jung, H., Meyer, J., Podobrin, O., Schröder, V., Winter, G. G., Bussey, P. J., Campbell, A. J., Hendry, D., Lumsdon, S., Skillicorn, I. O., Ahme, J., Blobel, V., Brehm, W., Feind, M., Fenner, H., Harjes, J., Köhne, J. H., Peters, J. H., Spitzer, H., Apel, W. -D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gabriel, P., Gamerdinger, K., Grosse-Wiesmann, P., Hahn, M., Hädinger, U., Hansmeyer, J., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., Seufert, R., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, Ch., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Journé, V., Kim, D. W., Le Diberder, F., Veillet, J. -J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., d'Agostini, G., Ferrarotto, F., Iacovacci, M., Shooshtari, G., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and CELLO Collaboration

Published
1990
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163. Inclusive strange particle production ine + e − annihilation

Author

Behrend, H. -J., Criegee, L., Field, J. H., Franke, G., Jung, H., Meyer, J., Podobrin, O., Schröder, V., Winter, G. G., Bussey, P. J., Campbell, A. J., Hendry, D., Lumsdon, S. J., Skillicorn, I. O., Ahme, J., Blobel, V., Brehm, W., Feindt, M., Fenner, H., Harjes, J., Köhne, J. H., Peters, J. H., Spitzer, H., Apel, W. -D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gabriel, P., Gamerdinger, K., Grosse-Wiesmann, P., Hahn, M., Hädinger, U., Hansmeyer, J., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., Seufert, R., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, Ch., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Journé, V., Kim, D. W., Le Diberder, F., Veillet, J. -J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., d'Agostini, G., Ferrarotto, F., Iacovacci, M., Shooshtari, G., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and Cello Collaboration

Published
1990
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164. Heavy quark charge asymmetries with the CELLO detector

Author

Behrend, H. J., Criegee, L., Field, J. H., Franke, G., Jung, H., Meyer, J., Podobrin, O., Schröder, V., Winter, G. G., Bussey, P. J., Campbell, A. J., Hendry, D., Lumsdon, S., Skillicorn, I. O., Ahme, J., Blobel, V., Brehm, W., Feindt, M., Fenner, H., Harjes, J., Köhne, J., Peters, J. H., Spitzer, H., Apel, W. D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gabriel, P., Gamerdinger, K., Grosse-Wiesmann, P., Hahn, M., Hädinger, U., Hansmeyer, J., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., Seufert, R., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, C., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Journé, V., Kim, D. W., Le Diberder, F., Veillet, J. J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., d'Agostini, G., Ferrarotto, F., Iacovacci, M., Shooshtari, G., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and CELLO Collaboration

Published
1990
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165. Measurement of inclusiveγ,π 0, andη production ine + e − annihilation at √s=35 GeV

Author

Behrend, H. J., Criegee, L., Dainton, J. B., Field, J. H., Franke, G., Jung, H., Meyer, J., Schröder, V., Winter, G. G., Bussey, P. J., Buttar, C., Campbell, A. J., Hendry, D., Scarr, J. M., Skillicorn, I. O., Smith, K. M., Ahme, J., Blobel, V., Brehm, W., Feindt, M., Fenner, H., Harjes, J., Peters, J. H., Podobrin, O., Spitzer, H., Apel, W. D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gabriel, P., Gamerdinger, K., Grosse-Wiesmann, P., Hahn, M., Hädinger, U., Hansmeyer, J., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., Seufert, R., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, C., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Shooshtari, G., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Janot, P., Journé, V., Kim, D. W., Le Diberder, F., Veillet, J. J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., d'Agostini, G., Ferrarotto, F., Iacovacci, M., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and CELLO Collaboration

Published
1990
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171. Magnetic helical micro-/nanomachines: Recent progress and perspective

Author

Dong, Yue, Wang, Lu, Iacovacci, Veronica, Wang, Xiaopu, Zhang, Li, and Nelson, Bradley J.

Abstract

Inspired by bacterial flagella, helical micro-/nanomachines (H-MNMs) can achieve controllable 3D movement by converting rotational motion to translation in a corkscrew fashion. Because they can be operated efficiently in narrow and confined spaces, functionalized with active components, and propelled by a magnetic field that does not harm tissue, H-MNMs have been extensively investigated to perform various biomedical tasks. Over the past decade of H-MNM development, significant research progress has been achieved, including cell stimulation, overcoming of biological barriers, targeted drug delivery, and imaging/tracking in vivo. This progress was enabled by the employment of new materials, structural designs, and functions. In this review, we summarize the latest developments of H-MNMs with a focus on their functionalization and key breakthroughs for biomedical applications. We also discuss the main challenges and future research directions to be undertaken to further advance these tiny corkscrew-like machines toward translational medicine and minimally invasive interventions.

Published
2022
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174. Changes in life expectancy for cancer patients over time since diagnosis.

Author

Botta, Laura, Dal Maso, Luigino, Guzzinati, Stefano, Panato, Chiara, Gatta, Gemma, Trama, Annalisa, Rugge, Massimo, Tagliabue, Giovanna, Casella, Claudia, Caruso, Bianca, Michiara, Maria, Ferretti, Stefano, Sensi, Flavio, Tumino, Rosario, Toffolutti, Federica, Russo, Antonio Giampiero, Caiazzo, Anna Luisa, Mangone, Lucia, Mazzucco, Walter, and Iacovacci, Silvia

Abstract

• Research question: how cancer impacts on LE changes during patients' entire life • LE increased in patients surviving the first years and decreasing thereafter. • Patients' LE in the long-term approached but seldom reached the general population's LE. • This method describes when cancer survivors' excess risk of death became negligible. • Life expectancy indicator is easy to be understood and interpreted by patients. The aims of this study were to provide life expectancy (LE) estimates of cancer patients at diagnosis and LE changes over time since diagnosis to describe the impact of cancer during patients' entire lives. Cancer patients' LE was calculated by standard period life table methodology using the relative survival of Italian patients diagnosed in population-based cancer registries in 1985–2011 with follow-up to 2013. Data were smoothed using a polynomial model and years of life lost (YLL) were calculated as the difference between patients' LE and that of the age- and sex-matched general population. The YLL at diagnosis was highest at the youngest age at diagnosis, steadily decreasing thereafter. For patients diagnosed at age 45 years, the YLL was above 20 for lung and ovarian cancers and below 6 for thyroid cancer in women and melanoma in men. LE progressively increased in patients surviving the first years, decreasing thereafter, to approach that of the general population. YLL in the long run mainly depends on attained age. Providing quantitative data is essential to better define clinical follow-up and plan health care resource allocation. These results help assess when the excess risk of death from tumour becomes negligible in cancer survivors. [ABSTRACT FROM AUTHOR]

Published
2019
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176. Rapidly mutating Y-STRs in rapidly expanding populations: Discrimination power of the Yfiler Plus multiplex in northern Africa.

Author

D'Atanasio, Eugenia, Iacovacci, Giuseppe, Pistillo, Rossella, Bonito, Maria, Dugoujon, Jean-Michel, Moral, Pedro, El-Chennawi, Farha, Melhaoui, Mohammed, Baali, Abdellatif, Cherkaoui, Mohamed, Sellitto, Daniele, Trombetta, Beniamino, Berti, Andrea, and Cruciani, Fulvio

Subjects
SHORT tandem repeat analysis, Y chromosome, HAPLOTYPES, DNA fingerprinting, ALLELES, GENETIC polymorphisms, POPULATION genetics
Abstract

Graphical abstract Highlights • The Y-STR profiles of 477 northern African males were obtained using the 27-loci Yfiler® Plus kit. • About 46% of the samples belonged to the recent E-M81 Y haplogroup. • The AMOVA analysis showed significant differences between populations and countries. • The number of identical Y-STR profiles was drastically reduced using the Yfiler® Plus compared to Yfiler. Abstract The male-specific northern African genetic pool is characterised by a high frequency of the E-M81 haplogroup, which expanded in very recent times (2–3 kiloyears ago). As a consequence of their recent coalescence, E-M81 chromosomes often cannot be completely distinguished on the basis of their Y-STR profiles, unless rapidly-mutating Y-STRs (RM Y-STRs) are analysed. In this study, we used the Yfiler® Plus kit, which includes 7 RM Y-STRs and 20 standard Y-STR, to analyse 477 unrelated males coming from 11 northern African populations sampled from Morocco, Algeria, Libya and Egypt. The Y chromosomes were assigned to monophyletic lineages after the analysis of 72 stable biallelic polymorphisms and, as expected, we found a high proportion of E-M81 subjects (about 46%), with frequencies decreasing from west to east. We found low intra-population diversity indexes, in particular in the populations that experienced long-term isolation. The AMOVA analysis showed significant differences between the countries and between most of the 11 populations, with a rough differentiation between northwestern Africa and northeastern Africa, where the Egyptians Berbers from Siwa represented an outlier population. The comparison between the Yfiler® and the Yfiler® Plus network of the E-M81 Y chromosomes confirmed the high power of discrimination of the latter kit, thanks to higher variability of the RM Y-STRs: indeed, the number of chromosomes sharing the same haplotype was drastically reduced from 201 to 81 and limited, in the latter case, to subjects from the same population. [ABSTRACT FROM AUTHOR]

Published
2019
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181. Model-independent limits on ΛQCD frome + e − annihilation in the energy range from 14 to 46 GeV

Author

Behrend, H. J., Criegee, L., Dainton, J. B., Field, J. H., Franke, G., Jung, H., Meyer, J., Schröder, V., Winter, G. G., Bussey, P. J., Buttar, C., Campbell, A. J., Hendry, D., Scarr, J. M., Skillicorn, I. O., Smith, K. M., Ahme, J., Blobel, V., Brehm, W., Feindt, M., Fenner, H., Harjes, J., Peters, J. H., Podobrin, O., Spitzer, H., Apel, W. D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gabriel, P., Gamerdinger, K., Grosse-Wiesmann, P., Hahn, M., Hädinger, U., Hansmeyer, J., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., Seufert, R., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, C., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Shooshtari, G., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Janot, P., Journé, V., Kim, D. W., Le Diberder, F., Veillet, J. J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., d'Agostini, G., Ferrarotto, F., Iacovacci, M., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and CELLO Collaboration

Published
1989
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182. TheK S 0 K S 0 final state in γγ interactions

Author

Behrend, H. -J., Criegee, L., Dainton, J. B., Field, J. H., Franke, G., Jung, H., Meyer, J., Schröder, V., Winter, G. G., Bussey, P. J., Buttar, C., Campbell, A. J., Hendry, D., McCurrach, G., Scarr, J. M., Skillicorn, I. O., Smith, K. M., Ahme, J., Blobel, V., Brehm, W., Feindt, M., Fenner, H., Harjes, J., Peters, J. H., Podobrin, O., Spitzer, H., Apel, W. -D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gabriel, P., Gamerdinger, K., Hansmeyer, J., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., Seufert, R., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, Ch., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Shooshtari, G., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Janot, P., Journé, V., Kim, D. W., Le Diberder, F., Veillet, J. -J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., d'Agostini, G., Ferrarotto, F., Iacovacci, M., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and CELLO Collaboration

Published
1989
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183. An experimental study ofe + e − annihilation into four leptons at $$\sqrt S \geqq 35$$ GeVGeV

Author

Behrend, H. -J., Criegee, L., Dainton, J. B., Field, J. H., Franke, G., Jung, H., Meyer, J., Schröder, V., Winter, G. G., Bussey, P. J., Buttar, C., Campbell, A. J., Hendry, D., McCurrach, G., Scarr, J. M., Skillicorn, I. O., Smith, K. M., Ahme, J., Blobel, V., Brehm, W., Feindt, M., Fenner, H., Harjes, J., Peters, J. H., Podobrin, O., Spitzer, H., Apel, W. -D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gabriel, P., Gamerdinger, K., Grosse-Wiesmann, P., Hahn, M., Hädinger, U., Hansmeyer, J., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., Seufert, R., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, Ch., Kotthaus, R., Kroha, H., Lüers, D., Oberlack, H., Schacht, P., Scholz, S., Shooshtari, G., Wiedenmann, W., Davier, M., Fournier, D., Grivaz, J. F., Haïssinski, J., Janot, P., Journé, V., Kim, D. W., Le Diberder, F., Veillet, J. -J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., D'Agostini, G., Ferrarotto, F., Iacovacci, M., Stella, B., Aleksan, R., Cozzika, G., Ducros, Y., Pierre, F., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milstène, C., and CELLO Collaboration

Published
1989
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184. K s 0 Kπ production in tagged and untagged γγ interactions

Author

Behrend, H. J., Criegee, L., Dainton, J. B., Field, J. H., Franke, G., Jung, H., Meyer, J., Schröder, V., Winter, G. G., Bussey, P. J., Buttar, C., Campbell, A. J., Hendry, D., McCurrach, G., Scarr, J. M., Skillicorn, I. O., Smith, K. M., Ahme, J., Blobel, V., Brehm, W., Feindt, M., Fenner, H., Harjes, J., Peters, J. H., Podobrin, O., Spitzer, H., Apel, W. -D., Engler, J., Flügge, G., Fries, D. C., Fuster, J., Gabriel, P., Gamerdinger, K., Grosse-Wiesmann, P., Hahn, M., Hädinger, U., Hansmeyer, J., Knapp, J., Küster, H., Müller, H., Ranitzsch, K. H., Schneider, H., Seufert, R., Wolf, J., de Boer, W., Buschhorn, G., Grindhammer, G., Gunderson, B., Kiesling, Ch., Kotthaus, R., Kroha, H., Lüers, D., Oberleck, H., Schacht, P., Scholz, S., Shooshtari, G., Wiedenmann, W., Davier, M., Grivaz, J. F., Haissinski, J., Janot, P., Journé, V., Kim D. W., Le Diberder, F., Veillet, J. -J., Blohm, K., George, R., Goldberg, M., Hamon, O., Kapusta, F., Poggioli, L., Rivoal, M., d'Agostini, G., Ferrarotto, F., Iacovacci, M., Stella, B., Cozzika, G., Ducros, Y., Alexander, G., Beck, A., Bella, G., Grunhaus, J., Klatchko, A., Levy, A., Milsténe, C., and CELLO Collaboration

Published
1989
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185. Neoadjuvant therapy for breast cancer

Author

Mangone, Lucia, Mancuso, Pamela, Tagliabue, Giovanna, Filiberti, Rosa Angela, Carrozzi, Giuliano, Iacovacci, Silvia, Mazzucco, Walter, Tumino, Rosario, Minicozzi, Pamela, Sant, Milena, and Giorgi Rossi, Paolo

Abstract

Objective: To evaluate the frequency of neoadjuvant therapy (NT) in women with stage I–III breast cancer in Italy and whether it is influenced by biological characteristics, screening history, and geographic area.Methods: Data from the High Resolution Study conducted in 7 Italian cancer registries were used; they are a representative sample of incident cancers in the study period (2009–2013). Included were 3546 women aged <85 years (groups <50, 50–69, 70–64, and 75+) with stage I–III breast cancer at diagnosis who underwent surgery. Women were classified as receiving NT if they received chemotherapy, target therapy, and/or hormone therapy before the first surgical treatment. Logistic models were built to test the association with biological and contextual variables.Results: Only 8.2% of women (290 cases) underwent NT; the treatment decreases with increasing age (14.5% in age <50 and 2.2% in age 75+), is more frequent in women with negative receptors (14.8%), HER2-positive (15.7%), and triple-negative (15.6%). The multivariable analysis showed the probability of receiving NT is higher in stage III (odds ratio [OR] 3.83; 95% confidence interval [CI] 2.83–5.18), luminal B (OR 1.87; 95% CI 1.27–2.76), triple-negatives (OR 1.88; 95% CI 1.15–3.08), and in symptomatic cancers (OR 1.98; 95% CI 1.13–3.48). Use of NT varied among geographic areas: Reggio Emilia had the highest rates (OR 2.29; 95% CI 1.37–3.82) while Palermo had the lowest (OR 0.41; 95% CI 0.24–0.68).Conclusions: The use of NT in Italy is limited and variable. There are no signs of greater use in hospitals with more advanced care.

Published
2019
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186. Cancer incidence and mortality trends from 2003 to 2014 in Italy

Author

Buzzoni, Carlotta, Crocetti, Emanuele, Guzzinati, Stefano, Dal Maso, Luigino, Francisci, Silvia, Mazzoleni, G, Ferrara, MA, Caputo, E, Coviello, E, Galasso, R, Citarella, A, Sampietro, G, Magoni, M, Ardizzone, A, D’Argenzio, A, Sutera Sardo, A, Giorno, A, La Greca, G, Ricci, P, Ferretti, S, Palma, F, Serraino, D, Iacovacci, S, Melcarne, A, Puppo, A, Sciacca, S, Russo, AG, Caruso, Bianca, Cavalieri d’Oro, L, D’Orsi, G, Fusco, M, Usala, M, Vitale, F, Cusimano, R, Michiara, M, Boschetti, L, Chiaranda, G, Rosso, S, Tumino, R, Mangone, L, Valenti Clemente, S, Falcini, F, Caiazzo, AL, Cesaraccio, R, Tisano, F, Fanetti, AC, Minerba, S, Caldarella, A, Candela, G, Piffer, S, Cania, A, Castelli, M, Pisani, M, Tagliabue, G, Bovo, E, and Brustolin, A

Abstract

Objective: To evaluate short-term (2003–2014) cancer incidence and mortality trends in Italy.Methods: Italian Cancer Registries data, available in the AIRTUM database, from 17 out of 20 regions were used. The number of incident cases and deaths were estimated for those registries and those years with incomplete information. Age-standardized rates, overall and stratified by geographic area, region, sex, cancer site, and major age group, were computed. Time trends were expressed as annual percent change of rates.Results: In Italy, among males, incidence rates for all cancers showed during 2003–2014, a significant decrease (−0.9%/year), with stronger reductions in the northwest (−1.3%/year) and northeast (−2.0%/year since 2006) than in central (−0.7%/year) and southern (−0.4%/year) areas. Among females, a weak but significant overall reduction was detected (−0.1%/year), with a stronger decrease in the northwest (−0.5%/year). Incidence increased among women in the south (0.3%/year) of Italy. Mortality decreased in both sexes (−1.0%/year among males and −0.5%/year among females), but not in the south, where rates had a stable tendency.Conclusions: Incidence among males decreased, supported by trends for prostate, lung, colorectal, and urinary bladder cancers; among females the. The overall cancer incidence trend was stable, or even decreasing, in the northern and central areas and increasing in the southern areas, due to lung, thyroid, and melanoma rising trends. Study results provided information on the outcomes, in terms of cancer incidence and mortality, of primary and secondary prevention measures employed by regional health systems.

Published
2019
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188. Dependence of the AUC of NTCP models on the observational dose-range highlights cautions in comparison of discriminative performance.

Author

Iacovacci, J., Palorini, F., Cicchetti, A., Fiorino, C., and Rancati, T.

Abstract

• AUC of dose–response models is sensitive to the observational dose-range of the fitted data • AUC value of NTCP models is driven by intrinsic characteristics of the model and by the clinical setting of the data used to develop them. • AUC is problematic when used to compare the discriminative performance of NTCP models. Normal tissue complication probability (NTCP) models are probabilistic models that describe the risk of radio-induced toxicity in tissues or organs. In the field of radiotherapy, the area under the ROC curve (AUC) is widely used to estimate the performance in risk prediction of NTCP models. In this work, we derived an analytical expression of the AUC for the logistic NTCP model in the case of both symmetrical and asymmetrical dose (to the normal tissue) windows around D 50. Using numerical simulations, we studied the behavior of the AUC in general clinical settings, enforcing non-logistic NTCP models (Lyman-Kutcher-Burman and LogEUD) and including risk factors beyond the dose. We validated our findings using real-world radiotherapy data sets of prostate cancer patients. Our analytical expression of the AUC made explicit the dependence on both the steepness of the logistic curve (β) and the dose window width (w), showing that an increase of w pushes AUC towards higher values. Increasing values of the AUC with increasing values of w were consistently observed across simulated data sets with diverse clinical settings from published studies and real clinical data sets. Our results reveal that the AUC of NTCP models inherits intrinsic characteristics from the clinical setting of the data set on which the models are developed, and warn against the use of the AUC to compare the performance of models constructed upon data from trials in which substantially different dose ranges were administered or accounting for different risk factors beyond the dose. [ABSTRACT FROM AUTHOR]

Published
2023
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189. Knowledge and health care resource allocation: CME/CPD course guidelines-based efficacy

Author

Braido, F., Comaschi, M., Valle, I., Delgado, L., Coccini, A., Guerreras, P., Stagi, E., Canonica, G. W., Arga, Study Group, Eaaci Cme, Committee, Angino, A., Baldacci, S., Borbotti, M., Cerrai, S., Di Pede, F., Maio, S., Mangione, M., Martini, F., Pala, P., Piegaia, B., Sarno, G., Silvi, P., Viegi, G., Dente, F., Bacci, E., Paggiaro, P., Bancalari, L., Foschino, M. P., Moscato, G., Pilucchi, A., Bresciani, M., Pierimarchi, P., Brunetto, B., Iacovacci, P., Pini, C., Tinghino, R., Forestiere, F., Perucci, C. A., Porta, D., Ancona, L., Protasi, S., Lazazzera, B., Ziroli, V., D Armini, E., Festa Campanile, S., Ferri, M., Lorusso, P., Pistelli, R., Salotti, R., Santagati, M., Casciari, C., Murgia, N., Spinozzi, F., Antonicelli, L., Braschi, M. C., Conti, V., Filippelli, A., Corbi, G. M., Giusy Russomanno, Baiardini, I., Balbi, F., Ferraioli, G., Bordo, A., Cerveri, I., Corsico, A., Grosso, A., Ansotegui, I. J., Gayraud, J., Nekam, K., Malling, H-J, Papadopolus, N., Popov, T., and Skevaki, C.

Subjects
Health Knowledge, Attitudes, Practice, diagnostic procedures, spirometry, continuing medical education, Pilot Projects, Guidelines, drugs, Education, General Practitioners, Medical, cost, Hypersensitivity, Humans, continuing professional development, Rhinitis, Practice, Asthma, hospitalization, medico-economic assessment, Health Knowledge, Continuing, Attitudes, Education, Medical, Continuing, Guideline Adherence
Abstract

Most health care systems consider continuing medical education a potential tool to improve quality of care and reduce disease management costs. Its efficacy in general practitioners needs to be further explored.This study assesses the effectiveness of a one-year continuing medical education/continuing professional development course for general practitioners, regarding the improvement in knowledge of ARIA and GINA guidelines and compliance with them in asthma management.Sixty general practitioners, covering 68,146 inhabitants, were randomly allocated to continuing medical education/continuing professional development (five residential events +four short distance-learning refresher courses over one year) or no training. Participants completed a questionnaire after each continuing medical education event; key questions were repeated at least twice. The Local Health Unit prescription database was used to verify prescription habits (diagnostic investigations and pharmacological therapy) and hospitalizations over one year before and after training.Fourteen general practitioners (46.7%) reached the cut-off of 50% attendance of the training courses. Knowledge improved significantly after training (p0.001, correct answers to key questions +13%). Training resulted in pharmaceutical cost containment (trained general practitioners +0.5% vs. controls +18.8%) and greater attention to diagnosis and monitoring (increase in spirometry +63.4%, p0.01).This study revealed an encouraging impact of educational events on improvement in general practitioner knowledge of guidelines and daily practice behavioral changes. Long-term studies of large populations are required to assess the effectiveness of education on the behavior of physicians in asthma management, and to establish the best format for educational events.

Published
2012

190. The ARGA study with general practitioners: Impact of medical education on asthma/rhinitis management

Author

Baldacci, S, Maio, S, Simoni, M, Cerrai, S, Sarno, G, Silvi, P, Di Pede, F, Borbotti, M, Pala, Ap, Bresciani, M, Viegi, G, Angino, Aa, Carrozzi, L, Mangione, M, Martini, F, Piegaia, Bb, Pistelli, F, Cardio Toracico, D, Bacci, E, Bancalari, L, Dente, F, Foschino, Mp, Moscato, Paggiaro, P, Pelucchi, A, Pierimarchi, P, Brunetto, B, Iacovacci, P, Pini, C, Tinghino, R, Forastiere, F, Perucci, Ca, Pistelli, R, Porta, D, Ancona, L, Protasi, S, Lazazzera, B, Ziroli, V, D'Armini, E, Campanile, Sf, Ferri, M, Lorusso, P, Salotti, R, Santagati, M, Agea, E, Casciari, C, Murgia, N, Spinozzi, F, Bonifazi, F, Antonicelli, L, Braschi, Mc, Conti, Valeria, Filippelli, Amelia, Corbi, Gm, Russomanno, G, Braido, F, Canonica, W, Baiardini, I, Francesco, B, Cerveri, I, Corsico, A, Grosso, A., Baldacci, S, Maio, S, Simoni, M, Cerrai, S, Sarno, G, Silvi, P, Di Pede, F, Borbotti, M, Pala, Ap, Bresciani, M, Viegi, G, Corbi, G, and as ARGA study, Group

Subjects
Male, Pediatrics, Asthma treatment, Practice Patterns, Group B, Allergic rhinitis, ARIA guidelines, Asthma, Drugs, GINA guidelines, Prescription adherence, Adult, Anti-Asthmatic Agents, Clinical Competence, Drug Compounding, Family Practice, Female, Glucocorticoids, Guideline Adherence, Histamine Antagonists, Humans, Italy, Middle Aged, Practice Guidelines as Topic, Practice Patterns, Physicians', Program Evaluation, Prospective Studies, Rhinitis, Young Adult, Education, Medical, Continuing, immune system diseases, Pulmonary and Respiratory Medicine, Severe persistent asthma, ARIA guideline, Gina guidelines, GINA guideline, Drug, medicine.medical_specialty, NO, Education, Medical, medicine, Allergic rhiniti, Medical education, Physicians', asthma, business.industry, Mean age, Continuing, medicine.disease, respiratory tract diseases, Concomitant, business
Abstract

Aim: To evaluate the impact of a medical education course (MEC) on the behaviour of general practitioners (GPs) to treat asthma and allergic rhinitis (AR). Methods: Data on 1820 patients (mean age 41yrs ± 17yrs) with asthma or AR were collected by 107 Italian GPs: 50% attended a MEC and 50% didn't (group B). The adherence for AR and asthma treatment was evaluated according to ARIA and GINA guidelines (GL). Results: AR and asthma were diagnosed in 78% and 56% of patients; 34% had concomitant AR and asthma. Regardless of the MEC, the adherence to GL was significantly higher for AR than for asthma treatment (52 versus 19%). Group B GPs were more compliant to ARIA guidelines in the treatment of mild AR, whereas group A were more compliant in the treatment of moderate-severe AR; the adherence didn't differ between the groups for AR patients with comorbid asthma. Adherence to GINA GL for asthma treatment did not differ between GPs of groups A and B, independently from concomitant AR. Though insignificantly, group A were more compliant to GINA GL in the treatment of patients with only severe persistent asthma (63 versus 46%) as group B were for patients with severe persistent asthma and concomitant AR. Conclusions: GPs often tend to treat patients independently from GL. The impact of a single MEC did not improve adherence to GL in treating less severe AR and asthma patients, while there was a trend towards the opposite attitude in more severe AR patients without concomitant asthma. © 2012 Elsevier Ltd. All rights reserved.

Published
2012

191. Impact of asthma and comorbid allergic rhinitis on quality of life and control in patients of italian general practitioners

Author

Maio, S, Baldacci, S, Simoni, M, Angino, A, Martini, F, Cerrai, S, Sarno, G, Pala, A, Bresciani, M, Paggiaro, P, Viegi, G, Alfredo, F, Sergio, N, Anna, S, Alessandro, A, Lucia, B, Diego, B, Francesco, Lf, Giuseppe, Np, Antonietta, Rm, Claudio, A, Marco, C, Mauro, M, Claudia, R, Giuseppina, C, Giovanna, C, Luigi, F, Andreina, F, Maurizio, Dm, Alessandro, Dp, Antonella, La, Davide, R, Mauro, B, Vincenzo, C, Bruno, G, Emiliano, A, Claudio, B, Lorenzo, D, Domenico, M, Giovanni, P, Marinella, P, Gabriella, V, Eliano, B, Marina, C, Khalid, K, Laura, P, Alberto, S, Caterina, T, Renata, T, Gianni, T, Emanuela, R, Mario, Tg, Tiziano, B, Chiara, C, Federica, G, Ivan, V, Eugenio, P, Enrico, C, Riccardo, M, Luigi, M, Filippo, T, Stefano, M, Gabriele, R, Marcello, B, Roberto, C, Donatella, C, Paola, G, Tiziano, L, Paolo, M, Giuliano, P, Michele, V, Roberto, B, Pietro, G, Angelo, M, Salvatore, Sd, Eleonora, T, Vito, A, Cosimo de, M, Donata, F, Gianmario, I, Luigi, L, Giovanna, L, Eugenio, M, Giorgio, M, Michele, M, Vito, M, Marco, M, Giuseppe, M, Pietro, S, Giovanni, S, Carlo, C, Paolo, G, Maria, I, Maria, L, Raffaele, M, Maria, Ng, Raffaele, P, Teodoro, R, Silvia, T, Carmelo, C, Daniele, I, Rita, S, Augusto, V, Nicolò, A, Antonio, B, Domenico, S, Antonio, Sg, Giovanni, Dg, Elio, Ds, Franco, Ag, Gianluigi, S, Raffaellina, S, Francesco, C, Antonio de, B, Arrigo, L, Marco, U, Angino, Aa, Borbotti, M, Carrozzi, L, Di Pede, F, Mangione, M, Pala, Ap, Piegaia, Bb, Pistelli, F, Silvi, P, Bacci, E, Bancalari, L, Dente, F, Foschino, Mp, Moscato, G, Pelucchi, A, Pierimarchi, P, Brunetto, B, Iacovacci, P, Pini, C, Tinghino, R, Forastiere, F, Perucci, Ca, Pistelli, R, Porta, D, Ancona, L, Protasi, S, Lazazzera, B, Ziroli, V, D'Armini, E, Campanile, Sf, Ferri, M, Lorusso, P, Salotti, R, Santagati, M, Agea, E, Casciari, C, Murgia, Nicola, Spinozzi, Fabrizio, Bonifazi, F, Antonicelli, L, Braschi, Mc, Conti, V, Filippelli, A, Corbi, Gm, Russomanno, G, Braido, F, Canonica, W, Baiardini, I, Francesco, B, Cerveri, I, Corsico, A, Grosso, A., Maio, S, Baldacci, S, Simoni, M, Angino, A, Martini, F, Cerrai, S, Sarno, G, Pala, A, Bresciani, M, Paggiaro, P, Viegi, G, Corbi, G, and as ARGA Study, Group

Subjects
Male, Pediatrics, Allergy, Allergies, Asthma, Primary care, Public health, Quality of life, Adolescent, Adult, Aged, Aged, 80 and over, Chi-Square Distribution, Family Practice, Female, Humans, Italy, Middle Aged, Prevalence, Quality of Life, Rhinitis, Allergic, Perennial, Surveys and Questionnaires, Young Adult, Pediatrics, Perinatology and Child Health, Immunology and Allergy, Pulmonary and Respiratory Medicine, Disease, 80 and over, Young adult, Rhinitis, education.field_of_study, Perinatology and Child Health, medicine.medical_specialty, education, Population, NO, Allergie, Allergic, medicine, Medical prescription, allergies, asthma, primary care, public health, quality of life, business.industry, medicine.disease, Perennial, Observational study, business
Abstract

Objective. Asthma is a disease with elevated prevalence within the general population. Although general practitioners (GPs) are among the first health-care professionals to whom patients refer for their symptoms, there are few evaluations of this disease based on data provided by the GPs. The aim of this observational study is to assess the impact of asthma and comorbid allergic rhinitis on individual/social burden, quality of life, and disease control in asthmatic patients of Italian GPs. Methods. Throughout Italy, 107 GPs enrolled 995 patients diagnosed with asthma and using anti-asthmatic drug prescriptions, or with asthma-like symptoms during the previous 12 months. Data were collected through questionnaires filled out by GPs and patients. Results. Of the 995 asthmatic patients, 60.6 had concomitant allergic rhinitis (RA), 39.4 had asthma alone. The latter, compared to those with RA, showed significantly lower prevalence of intermittent asthma (37.5 vs. 55.6) and higher prevalence of mild, moderate, and severe persistent asthma (28.4 vs. 23.2, 28.7 vs. 18.8, and 5.4 vs 2.4, respectively). Individual/social burden due to asthma was frequent and increased with disease severity: 87.5 of severe persistent asthma patients reported at least one medical consultation in the last 12 months, 37.5 emergency department visits, 26.7 hospitalization, and 62.5 limitations in daily activities. Control and quality of life were inversely associated with disease severity and were worse in patients with RA than in those with asthma alone. Conclusions. This study showed the negative impact of high severity levels and comorbid allergic rhinitis on quality of life of asthmatic patients and on individual/social burden due to asthma in an Italian GPs setting. © 2012 Informa Healthcare USA, Inc.

Published
2012

192. Forensic data and microvariant sequence characterization of 27 Y-STR loci analyzed in four Eastern African countries.

Author

Iacovacci, Giuseppe, D’Atanasio, Eugenia, Marini, Ornella, Coppa, Alfredo, Sellitto, Daniele, Trombetta, Beniamino, Berti, Andrea, and Cruciani, Fulvio

Subjects
FORENSIC genetics, NUCLEOTIDE sequence, ALLELES, GENE conversion, HAPLOTYPES
Abstract

By using the recently introduced 6-dye Yfiler ® Plus multiplex, we analyzed 462 males belonging to 20 ethnic groups from four eastern African countries (Eritrea, Ethiopia, Djibouti and Kenya). Through a Y-STR sequence analysis, combined with 62 SNP-based haplogroup information, we were able to classify observed microvariant alleles at four Y-STR loci as either monophyletic (DYF387S1 and DYS458) or recurrent (DYS449 and DYS627). We found evidence of non-allelic gene conversion among paralogous STRs of the two-copy locus DYF387S1. Twenty-two diallelic and triallelic patterns observed at 13 different loci were found to be significantly over-represented (p < 10 −6 ) among profiles obtained from cell lines compared to those from blood and saliva. Most of the diallelic/triallelic patterns from cell lines involved recurrent mutations at rapidly mutating loci (RM Y-STRs) included in the multiplex (p < 10 −2 ). At haplotype level, intra-population diversity indices were found to be among the lowest so far reported for the Yfiler ® Plus, while statistically significant differences among countries and ethnic groups were detected when considering haplotype frequencies alone (F ST ) or by using molecular distances among haplotypes (Φ ST ). The strong population subdivision observed is probably the consequence of the patrilineal social organization of most eastern African ethnic groups, and suggests caution in the use of country-based haplotype frequency distributions for forensic inferences in this region. [ABSTRACT FROM AUTHOR]

Published
2017
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194. Centralities of nodes and influences of layers in large multiplex networks

Author

Rahmede, Christoph, Iacovacci, Jacopo, Arenas, Alex, and Bianconi, Ginestra

Abstract

We formulate and propose an algorithm (MultiRank) for the weighted ranking of nodes and layers in large multiplex networks. MultiRank takes into account the full multiplex network structure of the data and exploits the dual nature of the network in terms of nodes and layers. The proposed centrality of the layers (influences) and the centrality of the nodes are determined by a coupled set of equations. The basic idea consist on assigning more centrality to nodes that are linked to central nodes in highly influential layers. The layers are more influential if highly central nodes are active in them. The algorithm applies to directed/undirected as well as to weighted/unweighted multiplex networks. We discuss the application of MultiRank to three major examples of multiplex network data sets: the European Air Transportation Multiplex Network, the Pierre Auger Multiplex Collaboration Network and the FAO Multiplex Trade Network.

Published
2018
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195. Nanocomposite thin films for triggerable drug delivery

Author

Vannozzi, Lorenzo, Iacovacci, Veronica, Menciassi, Arianna, and Ricotti, Leonardo

Abstract

ABSTRACTIntroduction: Traditional drug release systems normally rely on a passive delivery of therapeutic compounds, which can be partially programmed, prior to injection or implantation, through variations in the material composition. With this strategy, the drug release kinetics cannot be remotely modified and thus adapted to changing therapeutic needs. To overcome this issue, drug delivery systems able to respond to external stimuli are highly desirable, as they allow a high level of temporal and spatial control over drug release kinetics, in an operator-dependent fashion.Areas covered: On-demand drug delivery systems actually represent a frontier in this field and are attracting an increasing interest at both research and industrial level. Stimuli-responsive thin films, enabled by nanofillers, hold a tremendous potential in the field of triggerable drug delivery systems. The inclusion of responsive elements in homogeneous or heterogeneous thin film-shaped polymeric matrices strengthens and/or adds intriguing properties to conventional (bare) materials in film shape.Expert opinion: This Expert Opinion review aims to discuss the approaches currently pursued to achieve an effective on-demand drug delivery, through nanocomposite thin films. Different triggering mechanisms allowing a fine control on drug delivery are described, together with current challenges and possible future applications in therapy and surgery.

Published
2018
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198. Fondamenti per una metafisica dell’amore. Hannah Arendt e Agostino a confronto

Author

Iacovacci, Fabio

Abstract

L’obiettivo del presente contributo è quello di indagare sul significato di alcune categorie, usate da Agostino di Ippona, al fine di far emergere la loro incidenza nella speculazione di una grande pensatrice moderna, quale è stata Hannah Arendt. Ci si addentra nelle profondità del pensiero arendtiano attraverso l’analisi di alcuni testi tratti dalla dissertazione dottorale sul concetto d’amore in Agostino (1929). Mediante questo confronto diviene possibile, in particolare, porre in evidenza la profonda relazione che sussiste tra il concetto agostiniano di creaturalitàe quello arendtiano di natalitàche, per la pensatrice, fonda l’agire etico dell’uomo. In una cornice di spessore antropologico tale relazione viene analizzata gradualmente, procedendo dal piano individuale a quello sociale, e facendo emergere la profondità della teoria arendtiana dell’azioneche acquista senso e pienezza nella dimensione comunitaria.

Published
2017
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