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744 results on '"Hussain, Talib"'

152. Enhancement of Vancomycin Potential against Pathogenic Bacterial Strains via Gold Nano-Formulations: A Nano-Antibiotic Approach

Author

Hagbani, Turki Al, primary, Yadav, Hemant, additional, Moin, Afrasim, additional, Lila, Amr Selim Abu, additional, Mehmood, Khalid, additional, Alshammari, Farhan, additional, Khan, Salman, additional, Khafagy, El-Sayed, additional, Hussain, Talib, additional, Rizvi, Syed Mohd Danish, additional, and Abdallah, Marwa H., additional

Published
2022
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160. HPLC Method Validation for the Estimation of Lignocaine HCl, Ketoprofen and Hydrocortisone: Greenness Analysis Using AGREE Score.

Author

Mehmood, Tariq, Hanif, Sana, Azhar, Faiza, Ali, Ijaz, Alafnan, Ahmed, Hussain, Talib, Moin, Afrasim, Alamri, Mubarak A., and Syed, Muhammad Ali

Subjects
DOSAGE forms of drugs, LIDOCAINE, HIGH performance liquid chromatography, LIQUID chromatography, REVERSE phase liquid chromatography, RF values (Chromatography), NONSTEROIDAL anti-inflammatory agents
Abstract

In the current study, the reversed-phased high-pressure liquid chromatography (RP-HPLC) method was proposed for the estimation of lignocaine hydrochloride (LIG), hydrocortisone (HYD) and Ketoprofen (KET) according to International Conference for Harmonization (ICH) Q2 R1 guidelines, in a gel formulation. The chromatographic evaluation was executed using Shimadzu RP-HPLC, equipped with a C8 column and detected using UV at 254 nm wavelength, using acetonitrile and buffer (50:50) as a mobile phase and diluent, at flow rate 1 mL/min and n injection volume of 20 μL. The retention time for LIG, HYD, and KET were 1.54, 2.57, and 5.78 min, correspondingly. The resultant values of analytical recovery demonstrate accuracy and precision of the method and was found specific in identification of the drugs from dosage form and marketed products. The limit of detection (LOD) for LIG, HYD, and KET were calculated to be 0.563, 0.611, and 0.669 ppm, while the limit of quantification (LOQ) was estimated almost at 1.690, 1.833, and 0.223 ppm, respectively. The AGREE software was utilized to evaluate the greenness score of the proposed method, and it was found greener in score (0.76). This study concluded that the proposed method was simple, accurate, precise, robust, economical, reproducible, and suitable for the estimation of drugs in transdermal gels. [ABSTRACT FROM AUTHOR]

Published
2023
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164. Identifying the Most Potent Dual-Targeting Compound(s) against 3CLprotease and NSP15exonuclease of SARS-CoV-2 from Nigella sativa: Virtual Screening via Physicochemical Properties, Docking and Dynamic Simulation Analysis

Author

Rizvi, Syed Mohd Danish, primary, Hussain, Talib, additional, Moin, Afrasim, additional, Dixit, Sheshagiri R., additional, Mandal, Subhankar P., additional, Adnan, Mohd, additional, Jamal, Qazi Mohammad Sajid, additional, Sharma, Dinesh C., additional, Alanazi, Abulrahman Sattam, additional, and Unissa, Rahamat, additional

Published
2021
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167. NiCoFe oxide amorphous nanohetrostructres for oxygen evolution reaction

Author

Jizhao Zou, Haixia Qian, Qi Zhang, Muhammad Aurang Zeb Gul Sial, Yuechao Yao, Abdul Jalil, Shamraiz Hussain Talib, Xierong Zeng, Haifeng Lin, and Sambath Baskaran

Subjects
Materials science, Renewable Energy, Sustainability and the Environment, Oxygen evolution, Oxide, Energy Engineering and Power Technology, Nanoparticle, Substrate (electronics), Overpotential, Condensed Matter Physics, Amorphous solid, Anode, chemistry.chemical_compound, Fuel Technology, Chemical engineering, chemistry, Water splitting
Abstract

Two dimensional (2D) nanohetrostructures (NHS) composed of multimetal oxide nanoparticles (NPs) with site selective growth on either basal or lateral of the 2D multimetal oxide nanosheets (NSs) substrate are highly desirable due to their unique chemical and physical properties but extremely challenging in preparation. Herein, for the first time, we demonstrate the rational control growth of amorphous NiCoFeOx NPs on either lateral or basal of amorphous NiCoFeOx NSs by hydrothermal method. Owing to the lateral growth of amorphous NiCoFeOx NPs on the amorphous NiCoFeOx NSs, this unique architecture exhibits more electrocatalytic active sites and better stability due to higher In-plane conductivity than interlayer conductivity. Furthermore, density functional theory (DFT) calculation shows that due to the presence of low coordinated oxygen, it decreased the energy barrier of intermediates and enhanced the oxygen evolution reaction (OER) performance. While, NiCoFe oxide NHS with lateral growth of NiCoFeOx NPs lead to superior electrocatalytic activity toward oxygen evolution reaction (OER) with a low overpotential of 232 mV to reach a current density of 10 mAcm−2, due to the amorphous nature of NHS, synergistic effect, conductive support (like Nickel Foam) with metal oxide substrate. Furthermore, employing Lateral growth NHS as an anode and cathode for water splitting electrolyzer able to reach 10 mAcm−2 at a cell voltage of 1.49 V with robust durability. This work will provide a new dimension for the construction of other site selective 2D NHS with unique properties especially for OER.

Published
2019

171. Effect Of Aromatic Oil Of Three Plants Of Labiatae Gene On Microorganism By Using In Preservation Of Minced Meat.

Author

Abid, Majeed M., Hussain, Talib Kh., Hwaidi, Emad Hamid, and Kadhim, Hawraa I.

Subjects
*ESSENTIAL oils, *PLANT genes, *MICROBIAL genes, *MEAT preservation, *MEAT spoilage
Abstract

The effect of oil extracts of three plants of Labiatae gene, Mentha longifolia, M. spicata and Ocimum basilicum, by the agar well diffusion method, were studied, the total count of the bacteria responsible for spoilage meat was kept at 4-6˚C for different periods (1, 72,192) hours. The results showed that the oils extract were inhibited all the treatment that were studied and more affected inhibition of the growth of Staphylococcus aureus than the growth of other microbes. The total count of the bacteria responsible for meat spoilage decrease in all treatments extracted oils for all different periods. Statistic analysis results showed high significant variations at the level P≤ 0.01 of all the treatment and control for all reservation periods. [ABSTRACT FROM AUTHOR]

Published
2022
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183. Piperine phytosomes for bioavailability enhancement of domperidone.

Author

Islam, Nayyer, Irfan, Muhammad, Hussain, Talib, Mushtaq, Maria, Khan, Ikram Ullah, Yousaf, Abid Mehmood, Ghori, Muhammad Usman, and Shahzad, Yasser

Subjects
BIOAVAILABILITY, DRUG delivery systems, DOMPERIDONE, DRUG absorption, ZETA potential, P-glycoprotein
Abstract

The markedly low oral bioavailability of domperidone (anti-emetic drug) is associated with rapid first-pass metabolism in the intestine and liver. To counteract such affects, there is a need to devise a strategy to enhance absorption and subsequently bioavailability. Thus, the current study was aimed at synthesizing phytosomes consisting of phosphatidylcholine and piperine (a P-glycoprotein inhibitor). Phytosomes were prepared by salting-out method. The developed phytosomes were extensively characterized for size, zeta potential, polydispersity index, entrapment efficiency (EE %), infra-red spectroscopy, X-ray diffraction, in vitro drug release, ex vivo permeation, in vivo pharmacokinetic and toxicity. The engineered formulations of phytosomes with piperine exhibited a significant improvement in oral bioavailability of domperidone (79.5%) in comparison with the pure drug suspension under the same conditions. Pharmacokinetic parameters such as maximal plasma concentration (Cmax) and the plasma concentration (estimated from area under the curve; AUC) of domperidone have been greatly increased relative to drug alone. The improved drug absorption was attributed to inhibition of P-glycoprotein transporter. The findings of current research work suggest that the optimized phytosomes based drug delivery containing phytochemicals as bioenhancers have the potential to improve bioavailability of poorly bioavailable drugs that are substrate to P-glycoprotein. [ABSTRACT FROM AUTHOR]

Published
2022
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189. Electrospun Gelatin Nanocontainers for Enhanced Biopharmaceutical Performance of Piroxicam: In Vivo and In Vitro Investigations

Author

Zhao, Lin, Mustapha, Omer, Shafique, Shumaila, Jamshaid, Talha, Din, Fakhar ud, Mehmood, Yasir, Anwer, Khaleeq, Yousafi, Qurrat ul Ain, Hussain, Talib, Khan, Ikram Ullah, Ghori, Muhammad Usman, Shahzad, Yasser, and Yousaf, Abid Mehmood

Subjects
Male, Drug Carriers, piroxicam, gelatin encapsulation, nanocontainers, Biological Availability, electrospraying, Nanostructures, Rats, oral bioavailability, Electricity, Solubility, International Journal of Nanomedicine, aqueous solubility, Animals, Gelatin, Particle Size, Original Research
Abstract

Lin Zhao, 1 Omer Mustapha, 2 Shumaila Shafique, 2 Talha Jamshaid, 3 Fakhar ud Din, 4 Yasir Mehmood, 5 Khaleeq Anwer, 6 Qurrat ul Ain Yousafi, 7 Talib Hussain, 8 Ikram Ullah Khan, 5 Muhammad Usman Ghori, 9 Yasser Shahzad, 8 Abid Mehmood Yousaf 8 1Department of Rheumatology of Traditional Chinese and Western Medicine, Xinxiang Central Hospital, Xinxiang 453000, People’s Republic of China; 2Faculty of Pharmaceutical Sciences, Dow College of Pharmacy, Dow University of Health Sciences, Karachi 74200, Pakistan; 3Faculty of Pharmacy and Alternative Medicine, Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan; 4Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan; 5Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad 38040, Pakistan; 6Office of Chief Executive Officer, District Health Authority, Pakpattan 57400, Pakistan; 7Department of Neurosurgery, District Headquarters Hospital, Rawalpindi 46000, Pakistan; 8Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore 54000, Pakistan; 9Department of Pharmacy, School of Applied Science, University of Huddersfield, Huddersfield HD1 3DH, UKCorrespondence: Abid Mehmood Yousaf; Talib Hussain Tel +92-300-477-4147; +92-345-722-0536Email abid.ucp@hotmail.com Email talib.hussain@cuilahore.edu.pkBackground: Piroxicam exhibits low oral bioavailability, due to its meager solubility in water. The intent of this study was to ameliorate the bioavailability of the drug by employing a solubility-enhancing encapsulation technique.Methods: Seven samples were formulated with piroxicam and gelatin using both solvent evaporation and electrospraying together. Evaluation of solubility and release rate in water and assessment of bioavailability in rats were carried out in comparison with piroxicam plain drug powder (PPDP). Other in vitro explorations were accomplished using powder X-ray diffraction analysis, differential scanning calorimetry, thermogravimetric analysis, scanning electron microscopy, and Fourier-transform infrared spectroscopy.Results: All piroxicam-loaded gelatinnanocontainers (PLGNs) enhanced solubility and release of the payload in water. In particular, a PLGN formulation consisting of piroxicam and gelatin at a 1:8 (w:w) ratio presented about 600-fold the drug solubility of that shown by PPDP. Moreover, 85.12%± 10.96% of the payload was released from this formulation in 10 minutes which was significantly higher than that dissolved from PPDP in 10 minutes (11.81%± 5.34%). Drug content, drug loading, and encapsulation efficiency of this formulation were 93.41%± 0.56%, 10.45%± 0.06%, and 66.74%± 6.87%, respectively. The drug loaded in PLGNs existed in the amorphous state, as confirmed by X-ray diffraction and differential scanning–calorimetry analyses, and was more stable when analyzed by thermogravimetric analysis. Moreover, Fourier-transform infrared spectroscopy analysis suggested nonexistence of any piroxicam–gelatin interaction in the formulation. In the scanning electron–microscopy image, PLGNs appeared as round, smooth particles, with particle size of < 1,000 nm. Amelioration in bioavailability of piroxicam with the aforementioned PLGN formulation was fourfold that of PPDP.Conclusion: The PLGN formulation fabricated with piroxicam and gelatin at 1:8 (w:w) might be a promising system for enhanced biopharmaceutical performance of the drug.Keywords: aqueous solubility, electrospraying, gelatin encapsulation, nanocontainers, oral bioavailability, piroxicam

Published
2020

190. g-C3 N4 /CeO2 /Fe3 O4 Ternary Composite as an Efficient Bifunctional Catalyst for Overall Water Splitting

Author

Saif Ullah Awan, Tanveer ul Haq, Naveed Hussain, Nadia Parveen, Jamshaid Rashid, Muhammad Zaheer, Aneela Iqbal, and Shamraiz Hussain Talib

Subjects
Materials science, Organic Chemistry, Composite number, Graphitic carbon nitride, Oxygen evolution, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Catalysis, 0104 chemical sciences, Bifunctional catalyst, Inorganic Chemistry, chemistry.chemical_compound, chemistry, Chemical engineering, Water splitting, Hydrogen evolution, Physical and Theoretical Chemistry, 0210 nano-technology, Ternary operation
Published
2018

191. Electrospun Gelatin Nanocontainers for Enhanced Biopharmaceutical Performance of Piroxicam: In Vivo and In Vitro Investigations

Author

Zhao,Lin, Mustapha,Omer, Shafique,Shumaila, Jamshaid,Talha, Din,Fakhar ud, Mehmood,Yasir, Anwer,Khaleeq, Yousafi,Qurrat ul Ain, Hussain,Talib, Khan,Ikram Ullah, Ghori,Muhammad Usman, Shahzad,Yasser, Yousaf,Abid Mehmood, Zhao,Lin, Mustapha,Omer, Shafique,Shumaila, Jamshaid,Talha, Din,Fakhar ud, Mehmood,Yasir, Anwer,Khaleeq, Yousafi,Qurrat ul Ain, Hussain,Talib, Khan,Ikram Ullah, Ghori,Muhammad Usman, Shahzad,Yasser, and Yousaf,Abid Mehmood

Abstract

Lin Zhao, 1 Omer Mustapha, 2 Shumaila Shafique, 2 Talha Jamshaid, 3 Fakhar ud Din, 4 Yasir Mehmood, 5 Khaleeq Anwer, 6 Qurrat ul Ain Yousafi, 7 Talib Hussain, 8 Ikram Ullah Khan, 5 Muhammad Usman Ghori, 9 Yasser Shahzad, 8 Abid Mehmood Yousaf 8 1Department of Rheumatology of Traditional Chinese and Western Medicine, Xinxiang Central Hospital, Xinxiang 453000, People’s Republic of China; 2Faculty of Pharmaceutical Sciences, Dow College of Pharmacy, Dow University of Health Sciences, Karachi 74200, Pakistan; 3Faculty of Pharmacy and Alternative Medicine, Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan; 4Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320, Pakistan; 5Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad 38040, Pakistan; 6Office of Chief Executive Officer, District Health Authority, Pakpattan 57400, Pakistan; 7Department of Neurosurgery, District Headquarters Hospital, Rawalpindi 46000, Pakistan; 8Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore 54000, Pakistan; 9Department of Pharmacy, School of Applied Science, University of Huddersfield, Huddersfield HD1 3DH, UKCorrespondence: Abid Mehmood Yousaf; Talib Hussain Tel +92-300-477-4147; +92-345-722-0536Email abid.ucp@hotmail.com Email talib.hussain@cuilahore.edu.pkBackground: Piroxicam exhibits low oral bioavailability, due to its meager solubility in water. The intent of this study was to ameliorate the bioavailability of the drug by employing a solubility-enhancing encapsulation technique.Methods: Seven samples were formulated with piroxicam and gelatin using both solvent evaporation and electrospraying together. Evaluation of solubility and release rate in water and assessment of bioavailability in rats were carried out in comparison with piroxicam plain drug powder (PPDP). Other in vitro explorations were accomplished using powder X-ray diffraction analysis, differential scan

Published
2020

192. Electrosprayed Polymeric Nanospheres for Enhanced Solubility, Dissolution Rate, Oral Bioavailability and Antihyperlipidemic Activity of Bezafibrate

Author

Sun,Ru, Shen,Chengwu, Shafique,Shumaila, Mustapha,Omer, Hussain,Talib, Khan,Ikram Ullah, Mehmood,Yasir, Anwer,Khaleeq, Shahzad,Yasser, Yousaf,Abid Mehmood, Sun,Ru, Shen,Chengwu, Shafique,Shumaila, Mustapha,Omer, Hussain,Talib, Khan,Ikram Ullah, Mehmood,Yasir, Anwer,Khaleeq, Shahzad,Yasser, and Yousaf,Abid Mehmood

Abstract

Ru Sun, 1 Chengwu Shen, 1 Shumaila Shafique, 2 Omer Mustapha, 2 Talib Hussain, 3 Ikram Ullah Khan, 4 Yasir Mehmood, 4 Khaleeq Anwer, 5 Yasser Shahzad, 3 Abid Mehmood Yousaf 3 1Department of Pharmacy, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250000, People’s Republic of China; 2Faculty of Pharmaceutical Sciences, Dow College of Pharmacy, Dow University of Health Sciences, Karachi 74200, Pakistan; 3Department of Pharmacy, COMSATS University Islamabad, Lahore 54000, Pakistan; 4Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad 38000, Pakistan; 5Office of Chief Executive Officer, District Health Authority, Pakpattan 57400, PakistanCorrespondence: Abid Mehmood Yousaf; Talib HussainDepartment of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore 54000, PakistanTel +92-300-4774147; +92-345-7220536Email abid.ucp@hotmail.com; talib.hussain@cuilahore.edu.pkBackground: Bezafibrate is a BCS class II drug as it presents very low solubility in water; therefore, its bioavailability after oral administration is very poor. The aim of this work was to enhance solubility and dissolution rate of bezafibrate in water in order to enhance its oral bioavailability.Methods: Several formulations were prepared using PVP K30 and Cremophor ELP employing the solvent-evaporation method and the electrospraying technique. Solubility, release rate, bioavailability in male Sprague Dawley rats, and lipid profile attributes in Wistar rats were assessed in comparison with bezafibrate plain powder. Solid-state characterization was carried out using X-ray diffraction (XRD) analysis, differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM).Results: All the formulations exerted positive effect towards the desired goal. In particular, the optimized formulation furnished about 14-fold enhanced solubility and 85.48 ± 1

Published
2020

200. Formulation and characterization of lornoxicam-loaded cellulosic-microsponge gel for possible applications in arthritis

Author

He, Yeteng, primary, Majid, Khadija, additional, Maqbool, Maimoona, additional, Hussain, Talib, additional, Yousaf, Abid Mehmood, additional, Khan, Ikram Ullah, additional, Mehmood, Yasir, additional, Aleem, Ambreen, additional, Arshad, Muhammad Sohail, additional, Younus, Adnan, additional, Nirwan, Jorabar Singh, additional, Ghori, Muhammad Usman, additional, Rizvi, Syed A.A., additional, and Shahzad, Yasser, additional

Published
2020
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