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152. Transforming Growth Factor-β1 in predicting early lung fibroproliferation in patients with acute respiratory distress syndrome

Author

Forel, Jean-Marie, primary, Guervilly, Christophe, additional, Farnarier, Catherine, additional, Donati, Stéphane-Yannis, additional, Hraiech, Sami, additional, Persico, Nicolas, additional, Allardet-Servent, Jérôme, additional, Coiffard, Benjamin, additional, Gainnier, Marc, additional, Loundou, Anderson, additional, Sylvestre, Aude, additional, Roch, Antoine, additional, Bourenne, Jeremy, additional, and Papazian, Laurent, additional

Published
2018
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153. Erratum à « Pneumonies associées aux soins de réanimation » [Anesth. Reanim. 4 (5) (2018) 421–41]

Author

Leone, Marc, primary, Bouadma, Lila, additional, Bouhemad, Belaïd, additional, Brissaud, Olivier, additional, Dauger, Stéphane, additional, Gibot, Sébastien, additional, Hraiech, Sami, additional, Jung, Boris, additional, Kipnis, Eric, additional, Launey, Yoann, additional, Luyt, Charles-Edouard, additional, Margetis, Dimitri, additional, Michel, Fabrice, additional, Mokart, Djamel, additional, Montravers, Philippe, additional, Monsel, Antoine, additional, Nseir, Saad, additional, Pugin, Jérôme, additional, Roquilly, Antoine, additional, Velly, Lionel, additional, Zahar, Jean-Ralph, additional, Bruyère, Rémi, additional, and Chanques, Gérald, additional

Published
2018
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155. Preemptive ganciclovir for mechanically ventilated patients with cytomegalovirus reactivation.

Author

Papazian, Laurent, Jaber, Samir, Hraiech, Sami, Baumstarck, Karine, Cayot-Constantin, Sophie, Aissaoui, Nadia, Jung, Boris, Leone, Marc, Souweine, Bertrand, Schwebel, Carole, Bourenne, Jérémy, Allardet-Servent, Jérôme, Kamel, Toufik, Lu, Qin, Zandotti, Christine, Loundou, Anderson, Penot-Ragon, Christine, Chastre, Jean, Forel, Jean-Marie, and Luyt, Charles-Edouard

Subjects
BLOOD cell count, GANCICLOVIR, CYTOMEGALOVIRUSES, ARTIFICIAL respiration
Abstract

Background: The effect of cytomegalovirus (CMV) reactivation on the length of mechanical ventilation and mortality in immunocompetent ICU patients requiring invasive mechanical ventilation remains controversial. The main objective of this study was to determine whether preemptive intravenous ganciclovir increases the number of ventilator-free days in patients with CMV blood reactivation. Methods: This double-blind, placebo-controlled, randomized clinical trial involved 19 ICUs in France. Seventy-six adults ≥ 18 years old who had been mechanically ventilated for at least 96 h, expected to remain on mechanical ventilation for ≥ 48 h, and exhibited reactivation of CMV in blood were enrolled between February 5th, 2014, and January 23rd, 2019. Participants were randomized to receive ganciclovir 5 mg/kg bid for 14 days (n = 39) or a matching placebo (n = 37). Results: The primary endpoint was ventilator-free days from randomization to day 60. Prespecified secondary outcomes included day 60 mortality. The trial was stopped for futility based on the results of an interim analysis by the DSMB. The subdistribution hazard ratio for being alive and weaned from mechanical ventilation at day 60 for patients receiving ganciclovir (N = 39) compared with control patients (N = 37) was 1.14 (95% CI from 0.63 to 2.06; P = 0.66). The median [IQR] numbers of ventilator-free days for ganciclovir-treated patients and controls were 10 [0–51] and 0 [0–43] days, respectively (P = 0.46). Mortality at day 60 was 41% in patients in the ganciclovir group and 43% in the placebo group (P =.845). Creatinine levels and blood cells counts did not differ significantly between the two groups. Conclusions: In patients mechanically ventilated for ≥ 96 h with CMV reactivation in blood, preemptive ganciclovir did not improve the outcome. [ABSTRACT FROM AUTHOR]

Published
2021
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158. MOESM2 of Venovenous extracorporeal membrane oxygenation devices-related colonisations and infections

Author

Thomas, Guillemette, Hraiech, Sami, Cassir, Nadim, Lehingue, Samuel, Rambaud, Romain, Wiramus, Sandrine, Guervilly, Christophe, Klasen, Fanny, MĂŠlanie Adda, StĂŠphanie Dizier, Roch, Antoine, Papazian, Laurent, and Forel, Jean-Marie

Subjects
surgical procedures, operative
Abstract

Additional file 2. Table S2. Microorganisms cultured in blood culture (at the time of ECMO removal).

Published
2017
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160. Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial

Author

Jaber, Samir, primary, Paugam, Catherine, additional, Futier, Emmanuel, additional, Lefrant, Jean-Yves, additional, Lasocki, Sigismond, additional, Lescot, Thomas, additional, Pottecher, Julien, additional, Demoule, Alexandre, additional, Ferrandière, Martine, additional, Asehnoune, Karim, additional, Dellamonica, Jean, additional, Velly, Lionel, additional, Abback, Paër-Sélim, additional, de Jong, Audrey, additional, Brunot, Vincent, additional, Belafia, Fouad, additional, Roquilly, Antoine, additional, Chanques, Gérald, additional, Muller, Laurent, additional, Constantin, Jean-Michel, additional, Bertet, Helena, additional, Klouche, Kada, additional, Molinari, Nicolas, additional, Jung, Boris, additional, Jaber, Samir, additional, Monnin, Marion, additional, Delay, Jean-Marc, additional, Cissé, Moussa, additional, Geniez, Marie, additional, Conseil, Matthieu, additional, Souche, Bruno, additional, Constantin, Jean Michel, additional, Noll, Eric, additional, Morawiec, Elise, additional, Robert, Alexandre, additional, Triglia, Thibaut, additional, Mechati, Malika, additional, Arnal, Jean-Michel, additional, Durand-Gasselin, Jacques, additional, Demoly, Didier, additional, Hraiech, Sami, additional, Papazian, Laurent, additional, Gilles, Vincent, additional, Rimmelé, Thomas, additional, Riu, Béatrice, additional, Cougot, Pierre, additional, Fourcade, Olivier, additional, Seguin, Philippe, additional, Charbit, Jonathan, additional, Capdevila, Xavier, additional, Leone, Marc, additional, Zieleskiewicz, Laurent, additional, Ichai, Carole, additional, Orban, Jean Christophe, additional, Darmon, Michael, additional, Azoulay, Elie, additional, Lemiale, Virginie, additional, Zafrani, Lara, additional, Debbat, Karim, additional, Mimoz, Oliver, additional, Guérin, Claude, additional, and Kipnis, Eric, additional

Published
2018
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161. Venovenous extracorporeal membrane oxygenation devices-related colonisations and infections

Author

Thomas, Guillemette, primary, Hraiech, Sami, additional, Cassir, Nadim, additional, Lehingue, Samuel, additional, Rambaud, Romain, additional, Wiramus, Sandrine, additional, Guervilly, Christophe, additional, Klasen, Fanny, additional, Adda, Mélanie, additional, Dizier, Stéphanie, additional, Roch, Antoine, additional, Papazian, Laurent, additional, and Forel, Jean-Marie, additional

Published
2017
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162. Migrants in the intensive care unit: time to show we care.

Author

Hraiech, Sami, Papazian, Laurent, and Azoulay, Elie

Subjects
*INTENSIVE care units, *COMMUNITY-acquired infections, *EMIGRATION & immigration, *MEDICAL personnel, *IMMIGRANTS, *CHRONIC hepatitis B, *HEALTH facility translating services
Abstract

In addition, efforts to provide a safe environment to migrants have varied widely across countries and, in some cases, migrants are held in detention centers where the conditions are designed to be grim to discourage further migrants from coming. Every day, people leave their country, families, and belongings because of war, persecution, or poverty. A host of factors can put undocumented migrants at high risk for critical care illness (Fig. [Extracted from the article]

Published
2021
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163. How to reduce cisatracurium consumption in ARDS patients: the TOF-ARDS study

Author

Hraiech, Sami, primary, Forel, Jean-Marie, additional, Guervilly, Christophe, additional, Rambaud, Romain, additional, Lehingue, Samuel, additional, Adda, Mélanie, additional, Sylla, Pierre, additional, Valera, Sabine, additional, Carvelli, Julien, additional, Gainnier, Marc, additional, Papazian, Laurent, additional, and Bourenne, Jérémy, additional

Published
2017
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164. Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study

Author

Laffey, John G, primary, Madotto, Fabiana, additional, Bellani, Giacomo, additional, Pham, Tài, additional, Fan, Eddy, additional, Brochard, Laurent, additional, Amin, Pravin, additional, Arabi, Yaseen, additional, Bajwa, Ednan K, additional, Bruhn, Alejandro, additional, Cerny, Vladimir, additional, Clarkson, Kevin, additional, Heunks, Leo, additional, Kurahashi, Kiyoyasu, additional, Laake, Jon Henrik, additional, Lorente, Jose A, additional, McNamee, Lia, additional, Nin, Nicolas, additional, Palo, Jose Emmanuel, additional, Piquilloud, Lise, additional, Qiu, Haibo, additional, Jiménez, Juan Ignacio Silesky, additional, Esteban, Andres, additional, McAuley, Daniel F, additional, van Haren, Frank, additional, Ranieri, Marco, additional, Rubenfeld, Gordon, additional, Wrigge, Hermann, additional, Slutsky, Arthur S, additional, Pesenti, Antonio, additional, Laffey, John G., additional, Pham, Tai, additional, Gattinoni, Luciano, additional, Larsson, Anders, additional, McAuley, Daniel F., additional, Thompson, B Taylor, additional, Slutsky, Arthur S., additional, Rios, Fernando, additional, Sottiaux, Thierry, additional, Depuydt, Pieter, additional, Lora, Fredy S, additional, Azevedo, Luciano C, additional, Bugedo, Guillermo, additional, Gonzalez, Marcos, additional, Silesky, Juan, additional, Nielsen, Jonas, additional, Jibaja, Manuel, additional, Matamis, Dimitrios, additional, Ranero, Jorge L., additional, Hashemian, S.M., additional, Villagomez, Asisclo, additional, Zeggwagh, Amine Ali, additional, Heunks, Leo M, additional, Fernandes, Antero do Vale, additional, Sandesc, Dorel, additional, Arabi, Yaasen, additional, Bumbasierevic, Vesna, additional, Lorente, Jose A., additional, Abroug, Fekri, additional, Hurtado, Javier, additional, Bajwa, Ed, additional, Démpaire, Gabriel, additional, Sula, Hektor, additional, Nunci, Lordian, additional, Cani, Alma, additional, Zazu, Alan, additional, Dellera, Christian, additional, Alejandro, Risso V, additional, Daldin, Julio, additional, Fernandez, Ruben O, additional, Cardonnet, Luis P, additional, Bettini, Lisandro R., additional, Bisso, Mariano Carboni, additional, Osman, Emilio M., additional, Setten, Mariano G., additional, Lovazzano, Pablo, additional, Alvarez, Javier, additional, Villar, Veronica, additional, Pozo, Norberto C., additional, Grubissich, Nicolas, additional, Plotnikow, Gustavo A., additional, Vasquez, Daniela N., additional, Ilutovich, Santiago, additional, Tiribelli, Norberto, additional, Chena, Ariel, additional, Pellegrini, Carlos A., additional, Saenz, María G., additional, Estenssoro, Elisa, additional, Brizuela, Matias, additional, Gianinetto, Hernan, additional, Gomez, Pablo E., additional, Cerrato, Valeria I., additional, Bezzi, Marco G., additional, Borello, Silvina A., additional, Loiacono, Flavia A., additional, Fernandez, Adriana M., additional, Knowles, Serena, additional, Reynolds, Claire, additional, Inskip, Deborah M., additional, Miller, Jennene J, additional, Kong, Jing, additional, Whitehead, Christina, additional, Bihari, Shailesh, additional, Seven, Aylin, additional, Krstevski, Amanda, additional, Rodgers, Helen, additional, Millar, Rebecca, additional, Mckenna, Toni, additional, Bailey, Irene, additional, Hanlon, Gabrielle, additional, Aneman, Anders, additional, Lynch, Joan, additional, Azad, Raman, additional, Neal, John, additional, Woods, Paul, additional, Roberts, Brigit, additional, Kol, Mark, additional, Wong, Helen, additional, Riss, Katharina, additional, Staudinger, Thomas, additional, Wittebole, Xavier, additional, Berghe, Caroline, additional, Bulpa, Pierre, additional, Dive, Alain, additional, Verstraete, Rik, additional, Lebbinck, Herve, additional, Vermassen, Joris, additional, Meersseman, Philippe, additional, Ceunen, Helga, additional, Rosa, Jonas, additional, Beraldo, Daniel, additional, Piras, Claudio, additional, Rampinelli, Adenilton, additional, Nassar, Antonio, additional, Mataloun, Sergio, additional, Moock, Marcelo, additional, Thompson, Marlus, additional, Gonçalves, Claudio, additional, Antônio, Ana, additional, Ascoli, Aline, additional, Biondi, Rodrigo, additional, Fontenele, Danielle, additional, Nobrega, Danielle, additional, Sales, Vanessa, additional, Shindhe, Suresh, additional, Ismail, Dk, additional, Beloncle, Francois, additional, Davies, Kyle, additional, Cirone, Rob, additional, Manoharan, Venika, additional, Ismail, Mehvish, additional, Goligher, Ewan, additional, Jassal, Mandeep, additional, Nishikawa, Erin, additional, Javeed, Areej, additional, Curley, Gerard, additional, Rittayamai, Nuttapol, additional, Parotto, Matteo, additional, Ferguson, Niall, additional, Mehta, Sangeeta, additional, Knoll, Jenny, additional, Pronovost, Antoine, additional, Canestrini, Sergio, additional, Garcia, Patricio, additional, Aliaga, Felipe, additional, Farías, Pamela, additional, Yumha, Jacob, additional, Ortiz, Claudia, additional, Salas, Javier, additional, Saez, Alejandro, additional, Vega, Luis, additional, Labarca, Eduardo, additional, Martinez, Felipe, additional, Carreño, Nicolás, additional, Lora, Pilar, additional, Liu, Haitao, additional, Liu, Ling, additional, Tang, Rui, additional, Luo, Xiaoming, additional, An, Youzhong, additional, Zhao, Huiying, additional, Gao, Yan, additional, Zhai, Zhe, additional, Ye, Zheng, additional, Wang, Wei, additional, Li, Wenwen, additional, Li, Qingdong, additional, Zheng, Ruiqiang, additional, Yu, Wenkui, additional, Shen, Juanhong, additional, Li, Xinyu, additional, Yu, Tao, additional, Lu, Weihua, additional, Wu, Ya, additional, Huang, Xiao, additional, He, Zhenyang, additional, Lu, Yuanhua, additional, Han, Hui, additional, Zhang, Fan, additional, Sun, Renhua, additional, Wang, Hua, additional, Qin, Shu, additional, Zhu, Bao, additional, Zhao, Jun, additional, Liu, Jian, additional, Li, Bin, additional, Liu, Jing, additional, Zhou, Fa, additional, Li, Qiong, additional, Zhang, Xing, additional, Li-Xin, Zhou, additional, Xin-Hua, Qiang, additional, Jiang, Liangyan, additional, Gao, Yuan, additional, Zhao, Xian, additional, Li, Yuan, additional, Li, Xiao, additional, Wang, Chunting, additional, Yao, Qingchun, additional, Yu, Rongguo, additional, Chen, Kai, additional, Shao, Huanzhang, additional, Qin, Bingyu, additional, Huang, Qing, additional, Zhu, Wei, additional, Hang, Ai, additional, Hua, Ma, additional, Li, Yimin, additional, Xu, Yonghao, additional, Di, Yu, additional, Ling, Long, additional, Qin, Tie, additional, Wang, Shou, additional, Qin, Junping, additional, Han, Yi, additional, Zhou, Suming, additional, Vargas, Monica, additional, Jimenez, Juan, additional, Rojas, Manuel, additional, Solis-Quesada, Jaime, additional, Ramirez-Alfaro, Christian, additional, Máca, Jan, additional, Sklienka, Peter, additional, Gjedsted, Jakob, additional, Christiansen, Aage, additional, Villamagua, Boris, additional, Llano, Miguel, additional, Burtin, Philippe, additional, Buzancais, Gautier, additional, Beuret, Pascal, additional, Pelletier, Nicolas, additional, Mortaza, Satar, additional, Mercat, Alain, additional, Chelly, Jonathan, additional, Jochmans, Sébastien, additional, Terzi, Nicolas, additional, Daubin, Cédric, additional, Carteaux, Guillaume, additional, de Prost, Nicolas, additional, Chiche, Jean-Daniel, additional, Daviaud, Fabrice, additional, Fartoukh, Muriel, additional, Barberet, Guillaume, additional, Biehler, Jerome, additional, Dellamonica, Jean, additional, Doyen, Denis, additional, Arnal, Jean-Michel, additional, Briquet, Anais, additional, Hraiech, Sami, additional, Papazian, Laurent, additional, Roux, Damien, additional, Messika, Jonathan, additional, Kalaitzis, Evangelos, additional, Dangers, Laurence, additional, Combes, Alain, additional, Au, Siu-Ming, additional, Béduneau, Gaetan, additional, Carpentier, Dorothée, additional, Zogheib, Elie, additional, Dupont, Herve, additional, Ricome, Sylvie, additional, Santoli, Francesco, additional, Besset, Sebastien, additional, Michel, Philippe, additional, Gelée, Bruno, additional, Danin, Pierre-Eric, additional, Goubaux, Bernard, additional, Crova, Philippe, additional, Phan, Nga, additional, Berkelmans, Frantz, additional, Badie, Julio, additional, Tapponnier, Romain, additional, Gally, Josette, additional, Khebbeb, Samy, additional, Herbrecht, Jean-Etienne, additional, Schneider, Francis, additional, Declercq, Pierre-Louis, additional, Rigaud, Jean-Philippe, additional, Duranteau, Jacques, additional, Harrois, Anatole, additional, Chabanne, Russell, additional, Marin, Julien, additional, Bigot, Charlene, additional, Thibault, Sandrine, additional, Ghazi, Mohammed, additional, Boukhazna, Messabi, additional, Zein, Salem, additional, Richecoeur, Jack, additional, Combaux, Daniele, additional, Grelon, Fabien, additional, Le Moal, Charlene, additional, Sauvadet, Elise, additional, Robine, Adrien, additional, Lemiale, Virginie, additional, Reuter, Danielle, additional, Dres, Martin, additional, Demoule, Alexandre, additional, Goldgran-Toledano, Dany, additional, Baboi, Loredana, additional, Guérin, Claude, additional, Lohner, Ralph, additional, Kraßler, Jens, additional, Schäfer, Susanne, additional, Zacharowski, Kai, additional, Meybohm, Patrick, additional, Reske, Andreas, additional, Simon, Philipp, additional, Hopf, Hans-Bernd, additional, Schuetz, Michael, additional, Baltus, Thomas, additional, Papanikolaou, Metaxia, additional, Papavasilopoulou, Theonymfi, additional, Zacharas, Giannis, additional, Ourailogloy, Vasilis, additional, Mouloudi, Eleni, additional, Massa, Eleni, additional, Nagy, Eva, additional, Stamou, Electra, additional, Kiourtzieva, Ellada, additional, Oikonomou, Marina, additional, Avila, Luis, additional, Cortez, Cesar, additional, Citalán, Johanna, additional, Jog, Sameer, additional, Sable, Safal, additional, Shah, Bhagyesh, additional, Gurjar, Mohan, additional, Baronia, Arvind, additional, Memon, Mohammedfaruk, additional, Muthuchellappan, Radhakrishnan, additional, Ramesh, Venkatapura, additional, Shenoy, Anitha, additional, Unnikrishnan, Ramesh, additional, Dixit, Subhal, additional, Rhayakar, Rachana, additional, Ramakrishnan, Nagarajan, additional, Bhardwaj, Vallish, additional, Mahto, Heera, additional, Sagar, Sudha, additional, Palaniswamy, Vijayanand, additional, Ganesan, Deeban, additional, Hashemian, Seyed, additional, Jamaati, Hamidreza, additional, Heidari, Farshad, additional, Meaney, Edel, additional, Nichol, Alistair, additional, Knapman, Karl, additional, O'Croinin, Donall, additional, Dunne, Eimhin, additional, Breen, Dorothy, additional, Jaafar, Rola, additional, Dwyer, Rory, additional, Amir, Fahd, additional, Ajetunmobi, Olaitan, additional, O'Muircheartaigh, Aogan, additional, Black, Colin, additional, Treanor, Nuala, additional, Collins, Daniel, additional, Altaf, Wahid, additional, Zani, Gianluca, additional, Fusari, Maurizio, additional, Spadaro, Savino, additional, Volta, Carlo, additional, Graziani, Romano, additional, Brunettini, Barbara, additional, Palmese, Salvatore, additional, Formenti, Paolo, additional, Umbrello, Michele, additional, Lombardo, Andrea, additional, Pecci, Elisabetta, additional, Botteri, Marc, additional, Savioli, Monica, additional, Protti, Alessandro, additional, Mattei, Alessia, additional, Schiavoni, Lorenzo, additional, Tinnirello, Andrea, additional, Todeschini, Manuel, additional, Giarratano, Antonino, additional, Cortegiani, Andrea, additional, Sher, Sara, additional, Rossi, Anna, additional, Antonelli, Massimo, additional, Montini, Luca, additional, Casalena, Paolo, additional, Scafetti, Sergio, additional, Panarello, Giovanna, additional, Occhipinti, Giovanna, additional, Patroniti, Nicolò, additional, Pozzi, Matteo, additional, Biscione, Roberto, additional, Poli, Michela, additional, Raimondi, Ferdinando, additional, Albiero, Daniela, additional, Crapelli, Giulia, additional, Beck, Eduardo, additional, Pota, Vincenzo, additional, Schiavone, Vincenzo, additional, Molin, Alexandre, additional, Tarantino, Fabio, additional, Monti, Giacomo, additional, Frati, Elena, additional, Mirabella, Lucia, additional, Cinnella, Gilda, additional, Fossali, Tommaso, additional, Colombo, Riccardo, additional, Terragni, Pierpaolo, additional, Pattarino, Ilaria, additional, Mojoli, Francesco, additional, Braschi, Antonio, additional, Borotto, Erika, additional, Cracchiolo, Andrea, additional, Palma, Daniela, additional, Raponi, Francesco, additional, Foti, Giuseppe, additional, Vascotto, Ettore, additional, Coppadoro, Andrea, additional, Brazzi, Luca, additional, Floris, Leda, additional, Iotti, Giorgio, additional, Venti, Aaron, additional, Yamaguchi, Osamu, additional, Takagi, Shunsuke, additional, Maeyama, Hiroki, additional, Watanabe, Eizo, additional, Yamaji, Yoshihiro, additional, Shimizu, Kazuyoshi, additional, Shiozaki, Kyoko, additional, Futami, Satoru, additional, Ryosuke, Sekine, additional, Saito, Koji, additional, Kameyama, Yoshinobu, additional, Ueno, Keiko, additional, Izawa, Masayo, additional, Okuda, Nao, additional, Suzuki, Hiroyuki, additional, Harasawa, Tomofumi, additional, Nasu, Michitaka, additional, Takada, Tadaaki, additional, Ito, Fumihito, additional, Nunomiya, Shin, additional, Koyama, Kansuke, additional, Abe, Toshikazu, additional, Andoh, Kohkichi, additional, Kusumoto, Kohei, additional, Hirata, Akira, additional, Takaba, Akihiro, additional, Kimura, Hiroyasu, additional, Matsumoto, Shuhei, additional, Higashijima, Ushio, additional, Honda, Hiroyuki, additional, Aoki, Nobumasa, additional, Imai, Hiroshi, additional, Ogino, Yasuaki, additional, Mizuguchi, Ichiko, additional, Ichikado, Kazuya, additional, Nitta, Kenichi, additional, Mochizuki, Katsunori, additional, Hashida, Tomoaki, additional, Tanaka, Hiroyuki, additional, Nakamura, Tomoyuki, additional, Niimi, Daisuke, additional, Ueda, Takeshi, additional, Kashiwa, Yozo, additional, Uchiyama, Akinori, additional, Sabelnikovs, Olegs, additional, Oss, Peteris, additional, Haddad, Youssef, additional, Liew, Kong, additional, Ñamendys-Silva, Silvio, additional, Jarquin-Badiola, Yves, additional, Sanchez-Hurtado, Luis, additional, Gomez-Flores, Saira, additional, Marin, Maria, additional, Lemus, Jordana, additional, Fierro, Jonathan, additional, Cervantes, Mavy, additional, Mejia, Francisco, additional, Dector, Dulce M., additional, Gonzalez, Daniel, additional, Estrella, Claudia, additional, Sanchez-Medina, Jorge, additional, Ramirez-Gutierrez, Alvaro, additional, George, Fernando, additional, Aguirre, Janet, additional, Buensuseso, Juan, additional, Poblano, Manuel, additional, Dendane, Tarek, additional, Zeggwagh, Amine, additional, Balkhi, Hicham, additional, Elkhayari, Mina, additional, Samkaoui, Nacer, additional, Ezzouine, Hanane, additional, Benslama, Abdellatif, additional, Amor, Mourad, additional, Maazouzi, Wajdi, additional, Cimic, Nedim, additional, Beck, Oliver, additional, Bruns, Monique, additional, Schouten, Jeroen, additional, Rinia, Myra, additional, Raaijmakers, Monique, additional, Van Wezel, Hellen, additional, Heines, Serge, additional, Strauch, Ulrich, additional, Simonis, Fabienne, additional, Goodson, Jennifer, additional, Browne, Troy, additional, Navarra, Leanlove, additional, Hunt, Anna, additional, Hutchison, Robyn, additional, Bailey, Mathew, additional, Newby, Lynette, additional, Mcarthur, Colin, additional, Kalkoff, Michael, additional, Mcleod, Alex, additional, Casement, Jonathan, additional, Hacking, Danielle, additional, Andersen, Finn, additional, Dolva, Merete, additional, Laake, Jon, additional, Barratt-Due, Andreas, additional, Noremark, Kim, additional, Søreide, Eldar, additional, Sjøbø, Brit, additional, Guttormsen, Anne, additional, Yoshido, Hector, additional, Aguilar, Ronald, additional, Oscanoa, Fredy, additional, Alisasis, Alain, additional, Robles, Joanne, additional, Pasanting-Lim, Rossini, additional, Tan, Beatriz, additional, Andruszkiewicz, Pawel, additional, Jakubowska, Karina, additional, Coxo, Cristina, additional, Alvarez, António, additional, Oliveira, Bruno, additional, Montanha, Gustavo, additional, Barros, Nelson, additional, Pereira, Carlos, additional, Messias, António, additional, Monteiro, Jorge, additional, Araujo, Ana, additional, Catorze, Nuno, additional, Marum, Susan, additional, Bouw, Maria, additional, Gomes, Rui, additional, Brito, Vania, additional, Castro, Silvia, additional, Estilita, Joana, additional, Barros, Filipa, additional, Serra, Isabel, additional, Martinho, Aurelia, additional, Tomescu, Dana, additional, Marcu, Alexandra, additional, Bedreag, Ovidiu, additional, Papurica, Marius, additional, Corneci, Dan, additional, Negoita, Silvius, additional, Grigoriev, Evgeny, additional, Gritsan, Alexey, additional, Gazenkampf, Andrey, additional, Almekhlafi, Ghaleb, additional, Albarrak, Mohamad, additional, Mustafa, Ghanem, additional, Maghrabi, Khalid, additional, Salahuddin, Nawal, additional, Aisa, Tharwat, additional, Al Jabbary, Ahmed, additional, Tabhan, Edgardo, additional, Trinidad, Olivia, additional, Al Dorzi, Hasan, additional, Bolon, Stefan, additional, Smith, Oliver, additional, Mancebo, Jordi, additional, Aguirre-Bermeo, Hernan, additional, Lopez-Delgado, Juan, additional, Esteve, Francisco, additional, Rialp, Gemma, additional, Forteza, Catalina, additional, De Haro, Candelaria, additional, Albaiceta, Guillermo, additional, De Cima-Iglesias, Sara, additional, Seoane-Quiroga, Leticia, additional, Ceniceros-Barros, Alexandra, additional, Ruiz-Aguilar, Antonio, additional, Claraco-Vega, Luis, additional, Soler, Juan, additional, del Carmen Lorente, Maria, additional, Hermosa, Cecilia, additional, Gordo, Federico, additional, Prieto-González, Miryam, additional, López-Messa, Juan, additional, Perez, Manuel, additional, Perez, Cesar, additional, Allue, Raquel, additional, Roche-Campo, Ferran, additional, Ibañez-Santacruz, Marcos, additional, Temprano, Susana, additional, Pintado, Maria, additional, De Pablo, Raul, additional, Gómez, Pilar, additional, Ruiz, Silvia, additional, Moles, Silvia, additional, Jurado, Teresa, additional, Arizmendi, Alfons, additional, Piacentini, Enrique, additional, Franco, Nieves, additional, Honrubia, Teresa, additional, Cheng, Meisy, additional, Losada, Elena, additional, Blanco, Javier, additional, Yuste, Luis, additional, Carbayo-Gorriz, Cecilia, additional, Cazorla-Barranquero, Francisca, additional, Alonso, Javier, additional, Alda, Rosa, additional, Algaba, Ángela, additional, Navarro, Gonzalo, additional, Cereijo, Enrique, additional, Diaz-Rodriguez, Esther, additional, Marcos, Diego, additional, Montero, Laura, additional, Para, Luis, additional, Sanchez, Roberto, additional, Navalpotro, Miguel, additional, Abad, Ricardo, additional, González, Raquel, additional, Toribio, Dácil, additional, Castro, Alejandro, additional, Artiga, Maria, additional, Penuelas, Oscar, additional, Roser, Tomas, additional, Olga, Moreno, additional, Curto, Elena, additional, Sánchez, Rocío, additional, Imma, Vallverdu, additional, Elisabet, Garcia, additional, Claverias, Laura, additional, Magret, Monica, additional, Pellicer, Ana, additional, Rodriguez, Lucia, additional, Sánchez-Ballesteros, Jesús, additional, González-Salamanca, Ángela, additional, Jimenez, Antonio, additional, Huerta, Francisco, additional, Diaz, Juan, additional, Lopez, Esther, additional, Moya, David, additional, Alfonso, Alec, additional, Luis, Palazon, additional, Cesar, Palazon, additional, Rafael, Sánchez, additional, Virgilio, Corcoles, additional, Recio, Noelia, additional, Adamsson, Richard, additional, Rylander, Christian, additional, Holzgraefe, Bernhard, additional, Broman, Lars, additional, Wessbergh, Joanna, additional, Persson, Linnea, additional, Schiöler, Fredrik, additional, Kedelv, Hans, additional, Tibblin, Anna, additional, Appelberg, Henrik, additional, Hedlund, Lars, additional, Helleberg, Johan, additional, Eriksson, Karin, additional, Glietsch, Rita, additional, Larsson, Niklas, additional, Nygren, Ingela, additional, Nunes, Silvia, additional, Morin, Anna-Karin, additional, Kander, Thomas, additional, Adolfsson, Anne, additional, Zender, Hervé, additional, Leemann-Refondini, Corinne, additional, Elatrous, Souheil, additional, Bouchoucha, Slaheddine, additional, Chouchene, Imed, additional, Ouanes, Islem, additional, Souissi, Asma, additional, Kamoun, Salma, additional, Demirkiran, Oktay, additional, Aker, Mustafa, additional, Erbabacan, Emre, additional, Ceylan, Ilkay, additional, Girgin, Nermin, additional, Ozcelik, Menekse, additional, Ünal, Necmettin, additional, Meco, Basak, additional, Akyol, Onat, additional, Derman, Suleyman, additional, Kennedy, Barry, additional, Parhar, Ken, additional, Srinivasa, Latha, additional, McAuley, Danny, additional, Hopkins, Phil, additional, Mellis, Clare, additional, Kakar, Vivek, additional, Hadfield, Dan, additional, Vercueil, Andre, additional, Bhowmick, Kaushik, additional, Humphreys, Sally, additional, Ferguson, Andrew, additional, Mckee, Raymond, additional, Raj, Ashok, additional, Fawkes, Danielle, additional, Watt, Philip, additional, Twohey, Linda, additional, Jha, Rajeev, additional, Thomas, Matthew, additional, Morton, Alex, additional, Kadaba, Varsha, additional, Smith, Mark, additional, Hormis, Anil, additional, Kannan, Santhana, additional, Namih, Miriam, additional, Reschreiter, Henrik, additional, Camsooksai, Julie, additional, Kumar, Alek, additional, Rugonfalvi, Szabolcs, additional, Nutt, Christopher, additional, O'Neill, Orla, additional, Seasman, Colette, additional, Dempsey, Ged, additional, Scott, Christopher, additional, Ellis, Helen, additional, MckKechnie, Stuart, additional, Hutton, Paula, additional, Di Tomasso, Nora, additional, Vitale, Michela, additional, Griffin, Ruth, additional, Dean, Michael, additional, Cranshaw, Julius, additional, Willett, Emma, additional, Ioannou, Nicholas, additional, Gillis, Sarah, additional, Csabi, Peter, additional, Macfadyen, Rosaleen, additional, Dawson, Heidi, additional, Preez, Pieter, additional, Williams, Alexandra, additional, Boyd, Owen, additional, De Gordoa, Laura, additional, Bramall, Jon, additional, Symmonds, Sophie, additional, Chau, Simon, additional, Wenham, Tim, additional, Szakmany, Tamas, additional, Toth-Tarsoly, Piroska, additional, McCalman, Katie, additional, Alexander, Peter, additional, Stephenson, Lorraine, additional, Collyer, Thomas, additional, Chapman, Rhiannon, additional, Cooper, Raphael, additional, Allan, Russell, additional, Sim, Malcolm, additional, Wrathall, David, additional, Irvine, Donald, additional, Zantua, Kim, additional, Adams, John, additional, Burtenshaw, Andrew, additional, Sellors, Gareth, additional, Welters, Ingeborg, additional, Williams, Karen, additional, Hessell, Robert, additional, Oldroyd, Matthew, additional, Battle, Ceri, additional, Pillai, Suresh, additional, Kajtor, Istvan, additional, Sivashanmugavel, Mageswaran, additional, O'Kane, Sinead, additional, Donnelly, Adrian, additional, Frigyik, Aniko, additional, Careless, Jon, additional, May, Martin, additional, Stewart, Richard, additional, Trinder, T. John, additional, Hagan, Samantha, additional, Wise, Matt, additional, Cole, Jade, additional, MacFie, Caroline, additional, Dowling, Anna, additional, Nin, Nicolás, additional, Nuñez, Edgardo, additional, Pittini, Gustavo, additional, Rodriguez, Ruben, additional, Imperio, María, additional, Santos, Cristina, additional, França, Ana, additional, Ebeid, Alejandro, additional, Deicas, Alberto, additional, Serra, Carolina, additional, Uppalapati, Aditya, additional, Kamel, Ghassan, additional, Banner-Goodspeed, Valerie, additional, Beitler, Jeremy, additional, Mukkera, Satyanarayana, additional, Kulkarni, Shreedhar, additional, Lee, Jarone, additional, Mesar, Tomaz, additional, Shinn, John, additional, Gomaa, Dina, additional, Tainter, Christopher, additional, Yeatts, Dale, additional, Warren, Jessica, additional, Lanspa, Michael, additional, Miller, Russel, additional, Grissom, Colin, additional, Brown, Samuel, additional, Bauer, Philippe, additional, Gosselin, Ryan, additional, Kitch, Barrett, additional, Cohen, Jason, additional, Beegle, Scott, additional, Gueret, Renaud, additional, Tulaimat, Aiman, additional, Choudry, Shazia, additional, Stigler, William, additional, Batra, Hitesh, additional, Huff, Nidhi, additional, Lamb, Keith, additional, Oetting, Trevor, additional, Mohr, Nicholas, additional, Judy, Claine, additional, Saito, Shigeki, additional, Kheir, Fayez, additional, Schlichting, Adam, additional, Delsing, Angela, additional, Crouch, Daniel, additional, Elmasri, Mary, additional, Ismail, Dina, additional, Dreyer, Kyle, additional, Blakeman, Thomas, additional, Baron, Rebecca, additional, Grijalba, Carolina, additional, Hou, Peter, additional, Seethala, Raghu, additional, Aisiku, Imo, additional, Henderson, Galen, additional, Hou, Sen-Kuang, additional, Owens, Robert, additional, Schomer, Ashley, additional, Bumbasirevic, Vesna, additional, Jovanovic, Bojan, additional, Surbatovic, Maja, additional, and Veljovic, Milic, additional

Published
2017
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167. Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome

Author

Guervilly, Christophe, primary, Bisbal, Magali, additional, Forel, Jean Marie, additional, Mechati, Malika, additional, Lehingue, Samuel, additional, Bourenne, Jeremy, additional, Perrin, Gilles, additional, Rambaud, Romain, additional, Adda, Melanie, additional, Hraiech, Sami, additional, Marchi, Elisa, additional, Roch, Antoine, additional, Gainnier, Marc, additional, and Papazian, Laurent, additional

Published
2016
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168. Bacteriophage-based therapy in cystic fibrosis-associated Pseudomonas aeruginosa infections: rationale and current status

Author

Rolain, Jean-Marc, Hraiech,Sami, and Bregeon,Fabienne

Subjects
Drug Design, Development and Therapy
Abstract

Sami Hraiech,1,2 Fabienne Brégeon,1,3 Jean-Marc Rolain1 1Institut Hospitalo-Universitaire Méditerranée Infection, URMITE CNRS IRD INSERM UMR 7278, 2Réanimation Médicale – Détresses Respiratoires et Infections Sévères, APHM, CHU Nord, 3Service d’Explorations Fonctionnelles Respiratoires, APHM, CHU Nord, Marseille, France Abstract: Pulmonary infections involving Pseudomonas aeruginosa are among the leading causes of the deterioration of the respiratory status of cystic fibrosis (CF) patients. The emergence of multidrug-resistant strains in such populations, favored by iterative antibiotic cures, has led to the urgent need for new therapies. Among them, bacteriophage-based therapies deserve a focus. One century of empiric use in the ex-USSR countries suggests that bacteriophages may have beneficial effects against a large range of bacterial infections. Interest in bacteriophages has recently renewed in Western countries, and the in vitro data available suggest that bacteriophage-based therapy may be of significant interest for the treatment of pulmonary infections in CF patients. Although the clinical data concerning this specific population are relatively scarce, the beginning of the first large randomized study evaluating bacteriophage-based therapy in burn infections suggests that the time has come to assess the effectiveness of this new therapy in CF P. aeruginosa pneumonia. Consequently, the aim of this review is, after a brief history, to summarize the evidence concerning bacteriophage efficacy against P. aeruginosa and, more specifically, the in vitro studies, animal models, and clinical trials targeting CF. Keywords: pneumonia, pulmonary infection, bacterial infection, multidrug resistance

Published
2015

169. Animal models of polymicrobial pneumonia

Author

Rolain, Jean-Marc, Hraiech,Sami, Papazian,Laurent, and Bregeon,Fabienne

Subjects
Drug Design, Development and Therapy
Abstract

Sami Hraiech,1,2 Laurent Papazian,1,2 Jean-Marc Rolain,1 Fabienne Bregeon1,3IHU Méditerranée Infection, URMITE CNRS IRD INSERM UMR 7278, Marseille, France; 2Réanimation – Détresses respiratoires et Infections Sévères, APHM, CHU Nord, Marseille, France; 3Service d’Explorations Fonctionnelles Respiratoires, APHM, CHU Nord, Marseille, FranceAbstract: Pneumonia is one of the leading causes of severe and occasionally life-threatening infections. The physiopathology of pneumonia has been extensively studied, providing information for the development of new treatments for this condition. In addition to in vitro research, animal models have been largely used in the field of pneumonia. Several models have been described and have provided a better understanding of pneumonia under different settings and with various pathogens. However, the concept of one pathogen leading to one infection has been challenged, and recent flu epidemics suggest that some pathogens exhibit highly virulent potential. Although “two hits” animal models have been used to study infectious diseases, few of these models have been described in pneumonia. Therefore the aims of this review were to provide an overview of the available literature in this field, to describe well-studied and uncommon pathogen associations, and to summarize the major insights obtained from this information.Keywords: pneumonia, animal model, co-infections, polymicrobial, route of infection

Published
2015

170. Questions to improve family-staff communication in the ICU: a randomized controlled trial.

Author

Azoulay, Elie, Forel, Jean-Marie, Vinatier, Isabelle, Truillet, Romain, Renault, Anne, Valade, Sandrine, Jaber, Samir, Durand-Gasselin, Jacques, Schwebel, Carole, Georges, Hughes, Merceron, Sybille, Cariou, Alain, Moussa, Myriam, Hraiech, Sami, Argaud, Laurent, Leone, Marc, Curtis, J. Randall, Kentish-Barnes, Nancy, Jouve, Elisabeth, and Papazian, Laurent

Subjects
INTENSIVE care units, HOSPITALS, CONTROL groups, ANXIETY, SATISFACTION
Abstract

Purpose: Relatives of intensive care unit (ICU) patients suffer emotional distress that impairs their ability to acquire the information they need from the staff. We sought to evaluate whether providing relatives with a list of important questions was associated with better comprehension on day 5.Methods: Randomized, parallel-group trial. Relatives of mechanically ventilated patients were included from 14 hospitals belonging to the FAMIREA study group in France. A validated list of 21 questions was handed to the relatives immediately after randomization. The primary endpoint was comprehension on day 5. Secondary endpoints were satisfaction (Critical Care Family Needs Inventory, CCFNI) and symptoms of anxiety and depression (Hospital Anxiety and Depression Scale, HADS).Results: Of 394 randomized relatives, 302 underwent the day-5 assessment of all outcomes. Day-5 family comprehension was adequate in 68 (44.2%) and 75 (50.7%) intervention and control group relatives (P = 0.30), respectively. Over the first five ICU days, median number of family-staff meetings/patient was 6 [3-9], median total meeting time was 72.5 [35-110] min, and relatives asked a median of 20 [8-33] questions including 11 [6-13] from the list, with no between-group difference. Satisfaction and anxiety/depression symptoms were not significantly different between groups. The only variable significantly associated with better day-5 comprehension by multivariable analysis was a higher total number of questions asked before day 5.Conclusions: Providing relatives with a list of questions did not improve day-5 comprehension, secondary endpoints, or information time. Further research is needed to help families obtain the information they need.Trial Registration: ClinicalTrials.gov Identifier: NCT02410538. [ABSTRACT FROM AUTHOR]

Published
2018
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171. Impact of late administration of corticosteroids in COVID-19 ARDS.

Author

Mongardon, Nicolas, Piagnerelli, Michael, Grimaldi, David, Perrot, Bastien, Lascarrou, Jean-Baptiste, Aissaoui, Nadia, Blonz, Gauthier, Carbutti, Giuseppe, Courcelle, Romain, Gaudry, Stéphane, D'hondt, Alain, Higny, Julien, Horlait, Geoffrey, Hraiech, Sami, Lefebvre, Laurent, Lejeune, Francois, Ly, André, Pletschette, Zoe, Sauneuf, Bertrand, and Serck, Nicolas

Subjects
COVID-19, CORTICOSTEROIDS, ADULT respiratory distress syndrome
Abstract

We, therefore, aimed to evaluate the impact of late CTC for COVID-19 ARDS patients versus the absence of CTC administration. We studied patients who did not receive (no CTC group) or received CTC later than 13 days after symptoms onset (75% percentile of patients included in the RECOVERY trial [[1]]) (CTC group). To conclude, while early administration of low-dose CTC should be encouraged in severe COVID-19 pneumonia, late high-dose CTC appear to be non-beneficial in late non-resolving ARDS. [Extracted from the article]

Published
2021
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172. Haemophilus parahaemolyticus septic shock after aspiration pneumonia, France

Author

Le Floch, Anne-Sophie, Cassir, Nadim, Hraiech, Sami, Guervilly, Christophe, Papazian, Laurent, and Rolain, Jean-Marc

Subjects
Aspiration pneumonia -- Complications and side effects, Hemophilus infections -- Diagnosis, Septic shock -- Causes of, Health
Abstract

To the Editor: Members of the genus Haemophilus are commensal bacteria of the upper respiratory tract, and H. influenzae is the main pathogen in this genus that can cause a [...]

Published
2013
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174. Lack of viral clearance by the combination of hydroxychloroquine and azithromycin or lopinavir and ritonavir in SARS-CoV-2-related acute respiratory distress syndrome.

Author

Hraiech, Sami, Bourenne, Jérémy, Kuteifan, Khaldoun, Helms, Julie, Carvelli, Julien, Gainnier, Marc, Meziani, Ferhat, and Papazian, Laurent

Subjects
*ADULT respiratory distress syndrome, *RITONAVIR
Abstract

The current international outbreak of respiratory illness due to SARS-CoV-2 and named Covid-19 can evolve to severe progressive pneumonia and acute respiratory distress syndrome (ARDS), multiorgan failure, and death. Hydroxychloroquine has been found to be more potent than chloroquine to inhibit SARS-CoV-2 in vitro [[3]] and a recent report suggested that 70% of 20 non-ICU hydroxychloroquine-treated patients had negative PCR results in nasopharyngeal samples at day 6 (D6) post-inclusion [[4]] and in all the 6 patients treated with hydroxychloroquine and azithromycin combination (hydroxychloroquine-azithromycin) [[4]]. Although a positive PCR is not synonymous with active viral development, these results highlight the fact that neither of the treatments was able to achieve a rapid viral clearance in ARDS patients, as it has been suggested in one report on non-severe patients [[4]]. [Extracted from the article]

Published
2020
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176. Cytomegalovirus reactivation in ICU patients

Author

Papazian, Laurent, primary, Hraiech, Sami, additional, Lehingue, Samuel, additional, Roch, Antoine, additional, Chiche, Laurent, additional, Wiramus, Sandrine, additional, and Forel, Jean-Marie, additional

Published
2015
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178. Diagnostic yield and safety of CT scans in ICU

Author

Aliaga, Marine, primary, Forel, Jean-Marie, additional, De Bourmont, Sophie, additional, Jung, Boris, additional, Thomas, Guillemette, additional, Mahul, Martin, additional, Bisbal, Magali, additional, Nougaret, Stephanie, additional, Hraiech, Sami, additional, Roch, Antoine, additional, Chaumoitre, Kathia, additional, Jaber, Samir, additional, Gainnier, Marc, additional, and Papazian, Laurent, additional

Published
2014
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181. Type III procollagen is a reliable marker of ARDS-associated lung fibroproliferation

Author

Forel, Jean-Marie, primary, Guervilly, Christophe, additional, Hraiech, Sami, additional, Voillet, François, additional, Thomas, Guillemette, additional, Somma, Claude, additional, Secq, Véronique, additional, Farnarier, Catherine, additional, Payan, Marie-Josée, additional, Donati, Stéphanie-Yannis, additional, Perrin, Gilles, additional, Trousse, Delphine, additional, Dizier, Stéphanie, additional, Chiche, Laurent, additional, Baumstarck, Karine, additional, Roch, Antoine, additional, and Papazian, Laurent, additional

Published
2014
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183. A Rare Cause of Heart Failure Treated by Heart Transplantation: Noncompaction of the Ventricular Myocardium

Author

Bordes, Julien, Jop, Bertrand, Imbert, Sandrine, Hraiech, Sami, Collard, Frédéric, and Kerbaul, François

Subjects
Article Subject, cardiovascular system, cardiovascular diseases
Abstract

Noncompaction of the ventricular myocardium is a rare cardiomyopathy due to an arrest of myocardial morphogenesis. The characteristic echocardiographic findings are prominent myocardial trabeculations and deep intertrabecular spaces communicating with the left ventricular cavity. The clinical manifestations include heart failure (HF) signs, ventricular arrhythmias, and cardioembolic events. We describe an illustrative case of noncompaction of the ventricular myocardium associated with bicuspid aortic valve, a 42-year-old male presenting a refractory acute heart failure successfully treated by emergency heart transplantation.

Published
2009
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184. “RéaNet”, the Internet utilization among surrogates of critically ill patients with sepsis.

Author

Nguyen, Yên-Lan, Porcher, Raphaël, Argaud, Laurent, Piquilloud, Lise, Guitton, Christophe, Tamion, Fabienne, Hraiech, Sami, Mira, Jean-Paul, and null, null

Subjects
SEX surrogates, PATIENTS, CRITICALLY ill, INTENSIVE care units, SEPSIS
Abstract

Context: Health-related Internet utilization is common but its use by proxies of critically ill patients is unknown. Our objective was to describe the prevalence and the Internet utilization characteristics among surrogates of critically ill septic patients. We conducted a prospective observational study in French ICUs. Three survey instruments were used to describe ICU organization regarding information delivery, patients and surrogates characteristics. Results: 169 surrogates of 146 septic patients hospitalized in 19 ICUs were included. One sixth of ICUs (n = 3, 16%) had their own website. Majority of patients were males (n = 100, 68%), aged 64±1 years old, with a SAPS2 score at 53±17 and required vasopressors (n = 117, 83%), mechanical ventilation (n = 116, 82%). More than one quarter required renal replacement therapy (n = 36, 26%). Majority of surrogates were female, in their fifties. Only one in five knew the word sepsis (n = 27, 16%). Majority of proxies internet users (n = 77; 55%) search on the internet about sepsis. The main motivation was curiosity. Majority of surrogates found the information online reliable, suitable for request and concordant. Prior use of health-related Internet (OR = 20.7 [4.30–100.1]), the presence of a nursing staff during family-physician meetings (OR = 3.33 [1.17–9.53]), a younger patient age (OR = 1.32 [1.01–1.72]) and renal replacement therapy requirement (OR = 2.58 [1.06–6.26]) were associated with health-related Internet use. Neither satisfaction with medical care or information provision, neither presence of anxiety-depression symptoms, were associated with health-related Internet use. Majority of surrogates (N = 76 (52%)) would have like receiving a list of selected websites on sepsis. Conclusions: Majority of proxies of critically ill patients with sepsis use Internet to learn more about sepsis. Internet utilization is independent of satisfaction with global ICU care, perceived quality of information delivery by doctors or the existence of anxiety-depression symptoms during ICU stay. The delivery of a list of recommended web sites on sepsis would have been appreciated. [ABSTRACT FROM AUTHOR]

Published
2017
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185. Prone positioning and extracorporeal membrane oxygenation for severe acute respiratory distress syndrome: time for a randomized trial?

Author

Guervilly, Christophe, Prud'homme, Eloi, Pauly, Vanessa, Bourenne, Jérémie, Hraiech, Sami, Daviet, Florence, Adda, Mélanie, Coiffard, Benjamin, Forel, Jean Marie, Roch, Antoine, Persico, Nicolas, and Papazian, Laurent

Subjects
ADULT respiratory distress syndrome, EXTRACORPOREAL membrane oxygenation, TIME trials
Abstract

The authors discuss a retrospective observational study to compare outcomes of severe acute respiratory distress syndrome (ARDS) patients under veno-venous extracorporeal membrane oxygenation (vvECMO) according to the use of prone positioning (PP). Findings showed that patients with severe ARDS who underwent PP ECMO were more likely to be weaned from ECMO. They claim that findings from the study warrant justification for further clinical trials on the value of PP in ECMO.

Published
2019
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186. Pneumonies associées aux soins de réanimation

Author

Leone, Marc, Bouadma, Lila, Bouhemad, Belaïd, Brissaud, Olivier, Dauger, Stéphane, Gibot, Sébastien, Hraiech, Sami, Jung, Boris, Kipnis, Eric, Launey, Yoann, Luyt, Charles-Edouard, Margetis, Dimitri, Michel, Fabrice, Mokart, Djamel, Montravers, Philippe, Monsel, Antoine, Nseir, Saad, Pugin, Jérôme, Roquilly, Antoine, Velly, Lionel, Zahar, Jean-Ralph, Bruyère, Rémi, and Chanques, Gérald

Abstract

La Société française d’anesthésie et de réanimation et la Société de réanimation de langue française ont publié des recommandations se concentrant sur les pneumonies associées aux soins de réanimation. Le but de ces seize experts francophones était de produire un cadre permettant une meilleure prise de décision pour les médecins réanimateurs. Ces recommandations sont liées à trois sujets précis (la prévention, le diagnostique et le traitement) chez quatre types de patients (BPCO, neutropénie, postopération et pédiatrique). L’analyse littéraire et la formulation des recommandations ont été conduites selon le système GRADE. Une recherche littéraire extensive a été conduite sur 10 ans sur les publications indexées sur les bases de données Cochrane et Pubmed. Les pneumonies associées aux soins doivent être évitées grâce à une approche multimodale standardisée et en utilisant la décontamination digestive là où la prévalence des bactéries multi résistantes aux médicaments était inférieure à 20 %. Le diagnostique se base sur l’évaluation clinique et les analyses microbiologiques. En l’absence de facteurs de risques pour les bactéries multi résistantes, de bacille à gram-négatif non-fermentant et/ou d’une mortalité accrue (choc sceptique, défaillance organique), la monothérapie est fortement recommandée. Après documentation microbiologique, il est recommandé de réduire le spectre et de préférer la monothérapie pour l’antibiothérapie des pneumonies associées aux soins de réanimation, y compris les bacilles à gram-négatif non-fermentant.

Published
2018
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187. Outcome of acute respiratory distress syndrome patients treated with extracorporeal membrane oxygenation and brought to a referral center

Author

Roch, Antoine, primary, Hraiech, Sami, additional, Masson, Elodie, additional, Grisoli, Dominique, additional, Forel, Jean-Marie, additional, Boucekine, Mohamed, additional, Morera, Pierre, additional, Guervilly, Christophe, additional, Adda, Mélanie, additional, Dizier, Stéphanie, additional, Toesca, Richard, additional, Collart, Fréderic, additional, and Papazian, Laurent, additional

Published
2013
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192. Early Hepatic Dysfunction Is Associated with a Worse Outcome in Patients Presenting with Acute Respiratory Distress Syndrome: A Post-Hoc Analysis of the ACURASYS and PROSEVA Studies.

Author

Dizier, Stéphanie, Forel, Jean-Marie, Ayzac, Louis, Richard, Jean-Christophe, Hraiech, Sami, Lehingue, Samuel, Loundou, Anderson, Roch, Antoine, Guerin, Claude, Papazian, Laurent, and null, null

Subjects
ADULT respiratory distress syndrome, LIVER diseases, HEALTH outcome assessment, BLOOD pH, BILIRUBIN, MORTALITY, PATIENTS
Abstract

Introduction: Bilirubin is well-recognized marker of hepatic dysfunction in intensive care unit (ICU) patients. Multiple organ failure often complicates acute respiratory distress syndrome (ARDS) evolution and is associated with high mortality. The effect of early hepatic dysfunction on ARDS mortality has been poorly investigated. We evaluated the incidence and the prognostic significance of increased serum bilirubin levels in the initial phase of ARDS. Methods: The data of 805 patients with ARDS were retrospectively analysed. This population was extracted from two recent multicenter, prospective and randomised trials. Patients presenting with ARDS with a ratio of the partial pressure of arterial oxygen to the fraction of inspired oxygen < 150 mmHg measured with a PEEP ≥ 5 cm of water were included. The total serum bilirubin was measured at inclusion and at days 2, 4, 7 and 14. The primary objective was to analyse the bilirubin at inclusion according to the 90-day mortality rate. Results: The 90-day mortality rate was 33.8% (n = 272). The non-survivors were older, had higher Sepsis-related Organ Failure Assessment (SOFA) score and were more likely to have a medical diagnosis on admission than the survivors. At inclusion, the SOFA score without the liver score (10.3±2.9 vs. 9.0±3.0, p<0.0001) and the serum bilirubin levels (36.1±57.0 vs. 20.5±31.5 μmol/L, p<0.0001) were significantly higher in the non-survivors than in the survivors. Age, the hepatic SOFA score, the coagulation SOFA score, the arterial pH level, and the plateau pressure were independently associated with 90-day mortality in patients with ARDS. Conclusion: Bilirubin used as a surrogate marker of hepatic dysfunction and measured early in the course of ARDS was associated with the 90-day mortality rate. [ABSTRACT FROM AUTHOR]

Published
2015
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193. Cytomegalovirus and Herpes Simplex Virus Effect on the Prognosis of Mechanically Ventilated Patients Suspected to Have Ventilator-Associated Pneumonia

Author

Coisel, Yannael, primary, Bousbia, Sabri, additional, Forel, Jean-Marie, additional, Hraiech, Sami, additional, Lascola, Bernard, additional, Roch, Antoine, additional, Zandotti, Christine, additional, Million, Matthieu, additional, Jaber, Samir, additional, Raoult, Didier, additional, and Papazian, Laurent, additional

Published
2012
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