Search

Your search keyword '"Hirata, S."' showing total 1,723 results
Start Over Author "Hirata, S."
1,723 results on '"Hirata, S."'

151. A case of maxillary sarcoma in a chimpanzee (Pan troglodytes )

Author

Fujisawa, M., primary, Udono, T., additional, Nogami, E., additional, Hirosawa, M., additional, Morimura, N., additional, Saito, A., additional, Seres, M., additional, Teramoto, M., additional, Nagano, K., additional, Mori, Y., additional, Uesaka, H., additional, Nasu, K., additional, Tomonaga, M., additional, Idani, G., additional, Hirata, S., additional, Tsuruyama, T., additional, and Matsubayashi, K., additional

Published
2013
Full Text
View/download PDF

152. Responses to novel foods in captive chimpanzees

Author

Visalberghi E., Myowa Yamakoshi M., Hirata S., and Matsuzawa T.

Subjects
digestive, oral, and skin physiology
Abstract

Hesitancy to eat novel foods hampers the immediate enlargement of the diet but serves to limit the risk of ingesting toxic foods. Neophobia has been systematically investigated in only a few primate species and it seems affected by social influences. Surprisingly, little is known about chimpanzees' neophobia. We studied the response of 8 adult captive chimpanzees to 16 foods (foods commonly eaten by humans and never tasted before by chimpanzees). Each novel food was presented twice to the chimpanzee by a familiar or an unfamiliar human. Between the two trials the human ate the food face to face with the chimpanzee (demonstration). Results showed that some foods were almost unanimously accepted whereas others were not. Moreover, there were marked interindividual differences in food acceptance and consumption; chimpanzees ranged from being almost completely neophobic to accepting almost all foods. Familiarity with the human and the human's demonstration did not affect responses to the foods. Humans' predictions on chimpanzee's acceptance of the different foods were rather good; furthermore, in 7 cases out of 8 the human's preferences did not correlate with his/her predictions on chimpanzees' preferences. The finding that most captive chimpanzees are initially cautious towards novel foods supports the little information available for wild chimpanzees, whereas the lack of influence of the human's familiarity and demonstration on the response to food by chimpanzees calls for more naturalistic studies, in which social influences are provided by group members. Since novel stimuli provide sensory stimulation and elicit exploration and social interest, occasional presentation of novel foods could be a promising and cheap device for feeding enrichment.

Published
2002

153. DISSOCIATIVE RECOMBINATION OF VIBRATIONALLY COLD CH+3 AND INTERSTELLAR IMPLICATIONS

Author

Thomas, Richard, Kashperka, I., Vigren, Erik, Geppert, Wolf D., Hamberg, M., Larsson, Mats, af Ugglas, Magnus, Zhaunerchyk, Vitali, Indriolo, N., Yagi, K., Hirata, S., McCall, B. J., Thomas, Richard, Kashperka, I., Vigren, Erik, Geppert, Wolf D., Hamberg, M., Larsson, Mats, af Ugglas, Magnus, Zhaunerchyk, Vitali, Indriolo, N., Yagi, K., Hirata, S., and McCall, B. J.

Abstract

CH3+ is an important molecular ion in the astrochemistry of diffuse clouds, dense clouds, cometary comae, and planetary ionospheres. However, the rate of one of the major destruction mechanisms of CH3+, dissociative recombination (DR), has long been uncertain, hindering the use of CH3+ as an astrochemical probe. Here, we present the first absolute measurement of the DR of vibrationally cold CH3+, which has been made using the heavy storage ring CRYRING in Stockholm, Sweden. From our collision-energy-dependent cross sections, we infer a thermal rate constant of k(T) = 6.97(+/- 0.03) x 10(-7)(T/300)(-0.61(+/- 0.01)) cm(3) s(-1) over the region 10 K <= T <= 1000 K. At low collision energies, we have measured the branching fractions of the DR products to be CH3 (0.00(- 0.00)(+ 0.01)), CH2 + H (0.35(-0.01)(+ 0.01)), CH + 2H (0.20(-0.02)(+0.02)), CH + H-2 (0.10(-0.01)(+0.01)), and C + H-2 + H (0.35(-0.02)(+ 0.01)), indicating that two or more C-H bonds are broken in 65% of all collisions. We also present vibrational calculations which indicate that the CH3+ ions in the storage ring were relaxed to the vibrational ground state by spontaneous emission during the storage time. Finally, we discuss the implications of these new measurements for the observation of CH3+ in regions of the diffuse interstellar medium where CH+ is abundant., AuthorCount:12

Published
2012
Full Text
View/download PDF

154. Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats

Author

Kadowaki, D., Sumikawa, S., Arimizu, K., Taguchi, K., Kitamura, K., Ishitsuka, Y., Narita, Y., Irie, T., Chuang, Victor, Maruyama, T., Otagiri, M., Hirata, S., Kadowaki, D., Sumikawa, S., Arimizu, K., Taguchi, K., Kitamura, K., Ishitsuka, Y., Narita, Y., Irie, T., Chuang, Victor, Maruyama, T., Otagiri, M., and Hirata, S.

Abstract

Aims: Acetaminophen is a safe antipyretic and analgesic drug within the clinically recommended dosage range, but overdose can cause fatal liver and or kidney damage. Most of the nonsteroidal anti-inflammatory drugs (NSAIDs) exert their analgesic effect via inhibition of cyclooxygenase, which also results in a reduction of renal blood flow. Therefore, the use of NSAIDs in pain treatment for chronic kidney disease (CKD) patients is of particular concern. Acetaminophen lacks the anti-inflammatory and anti-coagulatory properties of the NSAIDs. In this study, we investigate whether acetaminophen has an impact on the progression of renal failure. Main methods: Acetaminophen (150 mg/kg/day or 750 mg/kg/day) or indomethacin (5 mg/kg/day) was orally administered to adenine-induced chronic renal failure model rats for 4 weeks. The plasma concentrations of acetaminophen and its metabolites were measured during the treatment period; renal function and oxidative stress in the rats were also monitored. Key findings: Indomethacin significantly decreased the survival rate of renal failure model rats. In contrast, both low (150 mg/kg) and high (750 mg/kg) doses of acetaminophen improved the survival rate. The progression of renal failure was attenuated by acetaminophen (750 mg/kg) after administration for 2 weeks. The metabolites of acetaminophen were found to accumulate in plasma. Plasma glutathione concentration had significantly recovered after acetaminophen administration. Significance: Acetaminophen has no effect on the progression of renal damage in adenine-induced renal failure model rats. This result is in part due to acetaminophen's antioxidant activity. These results suggest that acetaminophen is a suitable analgesic agent for treating CKD patients.

Published
2012

155. Toxicodynamic Evaluation of a Cisplatin-Chondroitin Sulfate Complex Using a Perfused Kidney and Human Proximal Tubular Cells

Author

Zhang, J., Kadowaki, D., Nonoguchi, H., Hirata, S., Seo, H., Imai, T., Suenaga, A., Chuang, Victor, Otagiri, M., Zhang, J., Kadowaki, D., Nonoguchi, H., Hirata, S., Seo, H., Imai, T., Suenaga, A., Chuang, Victor, and Otagiri, M.

Abstract

Cisplatin (CDDP) is an anticancer drug. The clinical limitations associated with CDDP have stimulated the development of macromolecular drug-carrier systems, in attempts to decrease its toxicity. A complex (CDDP-CSA-23) between CDDP and chondroitin sulfate (CSA), a natural polysaccharide with a mean molecular weight of 23 kDa, proved to have the same anticancer activity as CDDP. A toxicodynamic study was performed on perfused kidneys to determine the effect of CDDP-CSA-23 on renal functions and the extent of platinum accumulation. The results showed that CDDP-CSA-23 attenuates the reduction in urine flow and creatinine clearance induced by CDDP. Moreover, significantly lower amounts of platinum were excreted into the urine in the case of CDDP-CSA-23, compared with CDDP alone. Meanwhile, CDDP-CSA-23 effectively retarded the rapid perfusion of platinum into kidney tissues, as occurs when CDDP is being perfused alone.The cytoprotective effects of CDDP-CSA on human proximal tubular (HK-2) cells were examined by measuring the growth of HK-2 cells in the presence of CDDP or CDDP-CSA-23. Interestingly, CDDP-CSA-23 was found to have a significantly reduced cytotoxicity, compared to CDDP. These results suggest that CDDP-CSA-23 greatly decreased the negative effects of CDDP on glomerular filtration and tubular transport in kidneys at early stages of its administration.

Published
2011

166. SAT0012 A Multi-Biomarker Disease Activity (VECTRA™ DA Algorithm) Score is Associated with Radiographic Outcomes in RA Patients Treated with TNF Inhibitors

Author

Hirata, S., primary, Li, W., additional, Defranoux, N. A., additional, Bolce, R., additional, Haney, D. J., additional, Sasso, E. H., additional, Kubo, S., additional, Fukuyo, S., additional, Mizuno, Y., additional, Yamaoka, K., additional, Saito, K., additional, and Tanaka, Y., additional

Published
2013
Full Text
View/download PDF

168. Rapid disease progression correlates with instability of mutant SOD1 in familial ALS.

Author

Sato, T, Nakanishi, T, Yamamoto, Y, Andersen, P M, Ogawa, Y, Fukada, K, Zhou, Z, Aoike, F, Sugai, F, Nagano, S, Hirata, S, Ogawa, M, Nakano, R, Ohi, T, Kato, T, Nakagawa, M, Hamasaki, T, Shimizu, A, Sakoda, S, Sato, T, Nakanishi, T, Yamamoto, Y, Andersen, P M, Ogawa, Y, Fukada, K, Zhou, Z, Aoike, F, Sugai, F, Nagano, S, Hirata, S, Ogawa, M, Nakano, R, Ohi, T, Kato, T, Nakagawa, M, Hamasaki, T, Shimizu, A, and Sakoda, S

Published
2005

170. 1350 GRANULOCYTE APHERESIS FOR STEROID-NAIVE PATIENTS WITH SEVERE ALCOHOLIC HEPATITIS: A CASE SERIES

Author

Hasuike, S., primary, Nagata, K., additional, Yamada, Y., additional, Ohzono, Y., additional, Takeda, S., additional, Hirata, S., additional, Hidaka, M., additional, Natsuda, S., additional, Tsuchimochi, M., additional, Hashimoto, K., additional, Yamaji, T., additional, Nakamura, K., additional, Abe, H., additional, Miike, T., additional, Kusumoto, K., additional, Iwakiri, H., additional, Yamamoto, S., additional, and Shimoda, K., additional

Published
2012
Full Text
View/download PDF

173. A profile and flux monitor for the few GeV neutron beam at KEK

Author

Sasaki, T, Hasegawa, T, Hirata, S, Horikawa, N, Ishimoto, S, Iwata, T, Kawabata, M, Kim, Y D, Kovash, M A, Miyachi, Y, Mizuno, Y, Nakayama, F, Ogami, H, Ogawa, A, Sawada, S, Shibata, T A, Tamura, K, and Trice, J

Subjects
Accelerators and Storage Rings
Published
1995

179. Vibrational and electronic spectroscopy of acenaphthylene and its cation

Author

Banisaukas, J., Szczepanski, J., Eyler, J., Vala, M., Hirata, S., Head-Gordon, M., Oomens, J., Meijer, G.J.M., Helden, G.J. von, Banisaukas, J., Szczepanski, J., Eyler, J., Vala, M., Hirata, S., Head-Gordon, M., Oomens, J., Meijer, G.J.M., and Helden, G.J. von

Abstract

Contains fulltext : 98920.pdf (publisher's version ) (Open Access)

Published
2003

180. ACETATE INTOLERANCE IN HEMODIALYSIS

Author

Kishimoto, T., Yamamoto, K., Yamamoto, T., Mizutani, Y., Horiuchi, N., Hirata, S., Yamagami, S., Yamakawa, M., and Maekawa, M.

Published
1983

183. Emulsion-counter hybrid detector for the study of double hypernuclei and the H-dibaryon

Author

Aoki, S, Bahk, S Y, Chung, K S, Chung, S H, Fukuda, O, Hahn, C H, Hara, T, Hirata, S, Hoshino, K, Ieiri, M, Iijima, T, Imai, K, Ishigami, T, Kazuno, M, Kikuchi, K, Kim, C O, Kim, D C, Kim, J Y, Kim, T C, Kitamura, H, Kobayashi, M, Kodama, K, Maeda, Y, Masaike, A, Matsuda, Y, Minakawa, F, Miyanishi, M, Nagoshi, C, Nakamura, M, Nakanishi, S, Nakano, T, Nakazawa, K, Niu, K, Niwa, K, Okabe, H, Ono, S, Park, I G, Park, M S, Sato, Y, Shibuya, H, Shimizu, H M, Song, J S, Tajima, H, Takashima, R, Takeutchi, F, Tanaka, K H, Teranaka, M, Tezuka, I, Togawa, H, Ueda, Y, Ushida, N, Watanabe, S, Yoon, C S, and Yokota, J

Subjects
Detectors and Experimental Techniques
Published
1994

184. Identification of HLA-A2-restricted CTL epitopes of a novel tumour-associated antigen, KIF20A, overexpressed in pancreatic cancer

Author

Imai, K, primary, Hirata, S, additional, Irie, A, additional, Senju, S, additional, Ikuta, Y, additional, Yokomine, K, additional, Harao, M, additional, Inoue, M, additional, Tomita, Y, additional, Tsunoda, T, additional, Nakagawa, H, additional, Nakamura, Y, additional, Baba, H, additional, and Nishimura, Y, additional

Published
2010
Full Text
View/download PDF

193. Inhibition of in vitro vascular endothelial cell proliferation and in vivo neovascularization by low-dose methotrexate

Author

Hirata, S., Matsubara, T., Saura, R., Tateishi, H., and Hirohata, K.

Subjects
Rheumatoid arthritis -- Drug therapy, Methotrexate -- Research, Rheumatoid arthritis -- Physiological aspects, Methotrexate -- Usage, Cell research -- Methods, Vascular endothelium -- Research, Health
Abstract

When the synovial membrane, the inner layer of the joint capsule, is affected by rheumatism, chronic inflammation, the cells stimulate immune reactions that are responsible for continuing and worsening the rheumatoid synovitis. In order for this reaction to take place the formation of small new blood vessels, neovascularization, is necessary. One of the elements necessary for neovascularization is the growth and development of endothelial cells. If the development of endothelial cells and the consequent neovascularization can be prevented, it is possible that the inflammation of rheumatoid arthritis can be reduced. The authors questioned whether low-dose methotrexate, a drug commonly given to patients with rheumatoid arthritis, inhibits or slows the development of endothelial cells. A laboratory experiment focused on how methotrexate affects the synthesis of genetic material known as DNA, deoxyribonucleic acid, by human umbilical cord endothelial cells. The effects of methotrexate on the development of neovascularization in the cornea of the eye of rabbits was also studied. Data showed that methotrexate, in the dose usually given to rheumatoid patients, significantly inhibited the development of endothelial cells in humans. Methotrexate also inhibited neovascularization in the eyes of the rabbits. These results suggest that reducing neovascularization in the synovial membrane methotrexate effectively decreases the inflammation of rheumatoid arthritis.

Published
1989

198. A Neck-Collapsing-Type Lifshitz Transition Induced by Orbital Symmetry Breaking in Lightly Hole Doped t(2g) Bands

Author

Ikedo, K., Wakisaka, Y., Hirata, S., Takubo, Kou, and Mizokawa, T.

Subjects
Physics, symbols.namesake, Atomic orbital, Condensed matter physics, Jahn–Teller effect, Rotational symmetry, symbols, General Physics and Astronomy, Hexagonal lattice, Fermi surface, Symmetry breaking, Electronic band structure, Hamiltonian (quantum mechanics)
Abstract

We report on a new type of orbital symmetry breaking in the CoO 2 triangular lattice with hole doped t 2 g bands. Unrestricted Hartree–Fock calculations on a multi-orbital d – p Hamiltonian show that, in the lightly hole doped t 2 g bands, the e ' g orbitals are fully occupied with a circular charge distribution, and the doped holes in the a 1 g band form a hole pocket sandwiched by two concentric Fermi surfaces with sixfold (and almost continuous) rotational symmetry. This symmetric state has an instability to an anisotropic state with twofold rotational symmetry, where the hole pocket is split into two pieces. This transition is governed by the anisotropic interaction between the a 1 g and e ' g orbitals.

Published
2009

Catalog

Books, media, physical & digital resources
See catalog results