151. Alcoholic hepatomegaly: accumulation of protein in the liver.
- Author
-
Baraona E, Leo MA, Borowsky SA, and Lieber CS
- Subjects
- Albumins metabolism, Alcoholism complications, Alcoholism pathology, Animals, Cytosol metabolism, Ferritins metabolism, Hepatomegaly metabolism, Humans, Liver pathology, Male, Microtubules drug effects, Organ Size, Rats, Transferrin metabolism, Alcoholism metabolism, Hepatomegaly chemically induced, Liver metabolism, Proteins metabolism
- Abstract
The hepatomegaly that appears after long-term feeding of ethanol results in accumulation of protein that is quantitatively as important as the increase in lipid. The bulk of protein accumulated in the soluble fraction of the cell. Hepatic albumin and transferrin concentrations increase and colchicine-binding protein decreases, thus suggesting an intrahepatic retention of export proteins.
- Published
- 1975
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