Search

Your search keyword '"Heffler, Enrico"' showing total 1,159 results
Start Over Author "Heffler, Enrico"
1,159 results on '"Heffler, Enrico"'

151. Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy

Author

Chen, Wenjia, Sadatsafavi, Mohsen, Tran, Trung N., Murray, Ruth B., Wong, Chong Boon Nigel, Ali, Nasloon, Ariti, Cono, Gil, Esther Garcia, Newell, Anthony, Alacqua, Marianna, Al-Ahmad, Mona, Altraja, Alan, Al-Lehebi, Riyad, Bhutani, Mohit, Bjermer, Leif, Bjerrum, Anne Sofie, Bourdin, Arnaud, Bulathsinhala, Lakmini, Von Bülow, Anna, Busby, John, Canonica, Giorgio Walter, Carter, Victoria, Christoff, George C., Cosio, Borja G., Costello, Richard W., Fitzgerald, J. Mark, Fonseca, João A., Ha Yoo, Kwang, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Iwanaga, Takashi, Jackson, David J., Jones, Rupert C., Koh, Mariko Siyue, Kuna, Piotr, Larenas-Linnemann, Désirée, Lehmann, Sverre, Lehtimäki, Lauri A., Lyu, Juntao, Mahboub, Bassam, Maspero, Jorge, Menzies-Gow, Andrew N., Sirena, Concetta, Papadopoulos, Nikolaos, Papaioannou, Andriana I., De Llano, Luis Pérez, Perng, Diahn Warng, Peters, Matthew, Pfeffer, Paul E., Porsbjerg, Celeste M., Popov, Todor A., Rhee, Chin Kook, Salvi, Sundeep, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos A., Ulrik, Charlotte S., Won Ra, Seung, Wang, Eileen, Wechsler, Michael E., Price, David B., Chen, Wenjia, Sadatsafavi, Mohsen, Tran, Trung N., Murray, Ruth B., Wong, Chong Boon Nigel, Ali, Nasloon, Ariti, Cono, Gil, Esther Garcia, Newell, Anthony, Alacqua, Marianna, Al-Ahmad, Mona, Altraja, Alan, Al-Lehebi, Riyad, Bhutani, Mohit, Bjermer, Leif, Bjerrum, Anne Sofie, Bourdin, Arnaud, Bulathsinhala, Lakmini, Von Bülow, Anna, Busby, John, Canonica, Giorgio Walter, Carter, Victoria, Christoff, George C., Cosio, Borja G., Costello, Richard W., Fitzgerald, J. Mark, Fonseca, João A., Ha Yoo, Kwang, Heaney, Liam G., Heffler, Enrico, Hew, Mark, Hilberg, Ole, Hoyte, Flavia, Iwanaga, Takashi, Jackson, David J., Jones, Rupert C., Koh, Mariko Siyue, Kuna, Piotr, Larenas-Linnemann, Désirée, Lehmann, Sverre, Lehtimäki, Lauri A., Lyu, Juntao, Mahboub, Bassam, Maspero, Jorge, Menzies-Gow, Andrew N., Sirena, Concetta, Papadopoulos, Nikolaos, Papaioannou, Andriana I., De Llano, Luis Pérez, Perng, Diahn Warng, Peters, Matthew, Pfeffer, Paul E., Porsbjerg, Celeste M., Popov, Todor A., Rhee, Chin Kook, Salvi, Sundeep, Taillé, Camille, Taube, Christian, Torres-Duque, Carlos A., Ulrik, Charlotte S., Won Ra, Seung, Wang, Eileen, Wechsler, Michael E., and Price, David B.

Abstract

Background: Many severe asthma patients with high oral corticosteroid exposure (HOCS) often do not initiate biologics despite being eligible. This study aimed to compare the characteristics of severe asthma patients with HOCS who did and did not initiate biologics. Methods: Baseline characteristics of patients with HOCS (long-term maintenance OCS therapy for at least 1 year, or ≥4 courses of steroid bursts in a year) from the International Severe Asthma Registry (ISAR; https://isaregistries.org/), who initiated or did not initiate biologics (anti-lgE, anti-IL5/5R or anti-IL4R), were described at the time of biologic initiation or registry enrolment. Statistical relationships were tested using Pearson's chi-squared tests for categorical variables, and t-tests for continuous variables, adjusting for potential errors in multiple comparisons. Results: Between January 2015 and February 2021, we identified 1412 adult patients with severe asthma from 19 countries that met our inclusion criteria of HOCS, of whom 996 (70.5%) initiated a biologic and 416 (29.5%) did not. The frequency of biologic initiation varied across geographical regions. Those who initiated a biologic were more likely to have higher blood eosinophil count (483 vs 399 cells/µL, p=0.003), serious infections (49.0% vs 13.3%, p<0.001), nasal polyps (35.2% vs 23.6%, p<0.001), airflow limitation (56.8% vs 51.8%, p=0.013), and uncontrolled asthma (80.8% vs 73.2%, p=0.004) despite greater conventional treatment adherence than those who did not start a biologic. Both groups had similar annual asthma exacerbation rates in the previous 12 months (5.7 vs 5.3, p=0.147). Conclusion: Around one third of severe HOCS asthma patients did not receive biologics despite a similar high burden of asthma exacerbations as those who initiated a biologic therapy. Other disease characteristics such as eosinophilic phenotype, serious infectious events, nasal polyps, airflow limitation and lack of asthma control appear to di

Published
2022

152. Characterization of Patients in the International Severe Asthma Registry with High Steroid Exposure Who Did or Did Not Initiate Biologic Therapy

Author

Chen,Wenjia, Sadatsafavi,Mohsen, Tran,Trung N, Murray,Ruth B, Wong,Chong Boon Nigel, Ali,Nasloon, Ariti,Cono, Garcia Gil,Esther, Newell,Anthony, Alacqua,Marianna, Al-Ahmad,Mona, Altraja,Alan, Al-Lehebi,Riyad, Bhutani,Mohit, Bjermer,Leif, Bjerrum,Anne Sofie, Bourdin,Arnaud, Bulathsinhala,Lakmini, von Bülow,Anna, Busby,John, Canonica,Giorgio Walter, Carter,Victoria, Christoff,George C, Cosio,Borja G, Costello,Richard W, FitzGerald,J Mark, Fonseca,João A, Yoo,Kwang Ha, Heaney,Liam G, Heffler,Enrico, Hew,Mark, Hilberg,Ole, Hoyte,Flavia, Iwanaga,Takashi, Jackson,David J, Jones,Rupert C, Koh,Mariko Siyue, Kuna,Piotr, Larenas-Linnemann,Désirée, Lehmann,Sverre, Lehtimäki,Lauri A, Lyu,Juntao, Mahboub,Bassam, Maspero,Jorge, Menzies-Gow,Andrew N, Sirena,Concetta, Papadopoulos,Nikolaos, Papaioannou,Andriana I, Pérez de Llano,Luis, Perng,Diahn-Warng, Peters,Matthew, Pfeffer,Paul E, Porsbjerg,Celeste M, Popov,Todor A, Rhee,Chin Kook, Salvi,Sundeep, Taillé,Camille, Taube,Christian, Torres-Duque,Carlos A, Ulrik,Charlotte S, Ra,Seung Won, Wang,Eileen, Wechsler,Michael E, Price,David B, Chen,Wenjia, Sadatsafavi,Mohsen, Tran,Trung N, Murray,Ruth B, Wong,Chong Boon Nigel, Ali,Nasloon, Ariti,Cono, Garcia Gil,Esther, Newell,Anthony, Alacqua,Marianna, Al-Ahmad,Mona, Altraja,Alan, Al-Lehebi,Riyad, Bhutani,Mohit, Bjermer,Leif, Bjerrum,Anne Sofie, Bourdin,Arnaud, Bulathsinhala,Lakmini, von Bülow,Anna, Busby,John, Canonica,Giorgio Walter, Carter,Victoria, Christoff,George C, Cosio,Borja G, Costello,Richard W, FitzGerald,J Mark, Fonseca,João A, Yoo,Kwang Ha, Heaney,Liam G, Heffler,Enrico, Hew,Mark, Hilberg,Ole, Hoyte,Flavia, Iwanaga,Takashi, Jackson,David J, Jones,Rupert C, Koh,Mariko Siyue, Kuna,Piotr, Larenas-Linnemann,Désirée, Lehmann,Sverre, Lehtimäki,Lauri A, Lyu,Juntao, Mahboub,Bassam, Maspero,Jorge, Menzies-Gow,Andrew N, Sirena,Concetta, Papadopoulos,Nikolaos, Papaioannou,Andriana I, Pérez de Llano,Luis, Perng,Diahn-Warng, Peters,Matthew, Pfeffer,Paul E, Porsbjerg,Celeste M, Popov,Todor A, Rhee,Chin Kook, Salvi,Sundeep, Taillé,Camille, Taube,Christian, Torres-Duque,Carlos A, Ulrik,Charlotte S, Ra,Seung Won, Wang,Eileen, Wechsler,Michael E, and Price,David B

Abstract

Wenjia Chen,1 Mohsen Sadatsafavi,2 Trung N Tran,3 Ruth B Murray,4 Chong Boon Nigel Wong,1 Nasloon Ali,4,5 Cono Ariti,4,5 Esther Garcia Gil,6 Anthony Newell,5,7 Marianna Alacqua,8 Mona Al-Ahmad,9 Alan Altraja,10 Riyad Al-Lehebi,11,12 Mohit Bhutani,13 Leif Bjermer,14 Anne Sofie Bjerrum,15 Arnaud Bourdin,16 Lakmini Bulathsinhala,4,5 Anna von Bülow,17 John Busby,18 Giorgio Walter Canonica,19,20 Victoria Carter,4,5 George C Christoff,21 Borja G Cosio,22 Richard W Costello,23 J Mark FitzGerald,24 João A Fonseca,25 Kwang Ha Yoo,26 Liam G Heaney,27 Enrico Heffler,19,20 Mark Hew,28,29 Ole Hilberg,30 Flavia Hoyte,31,32 Takashi Iwanaga,33 David J Jackson,34,35 Rupert C Jones,36 Mariko Siyue Koh,37,38 Piotr Kuna,39 Désirée Larenas-Linnemann,40 Sverre Lehmann,41 Lauri A Lehtimäki,42,43 Juntao Lyu,5,7 Bassam Mahboub,44,45 Jorge Maspero,46,47 Andrew N Menzies-Gow,48 Concetta Sirena,49 Nikolaos Papadopoulos,50,51 Andriana I Papaioannou,52 Luis Pérez de Llano,53,54 Diahn-Warng Perng,55,56 Matthew Peters,57 Paul E Pfeffer,58,59 Celeste M Porsbjerg,17 Todor A Popov,60 Chin Kook Rhee,61 Sundeep Salvi,62 Camille Taillé,63 Christian Taube,64 Carlos A Torres-Duque,65 Charlotte S Ulrik,66 Seung Won Ra,67 Eileen Wang,31,32 Michael E Wechsler,68 David B Price4,5,69 1Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; 2Respiratory Evaluation Sciences Program, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada; 3AstraZeneca, Gaithersburg, MD, USA; 4Optimum Patient Care, Cambridge, UK; 5Observational and Pragmatic Research Institute, Singapore, Singapore; 6AstraZeneca, Barcelona, Spain; 7Optimum Patient Care, Queensland, VIC, Australia; 8AstraZeneca, Cambridge, UK; 9Microbiology Department, Faculty of Medicine, Kuwait University, Al-Rashed Allergy Center, Ministry of Health, Kuwait City, Kuwait; 10Department of Pulmonology, University of Tartu and Lung Clinic, Tartu University Hospital, Tartu, Estonia; 11De

Published
2022

153. Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food—A first step in an initiative to better inform patients and avoid fatal allergic reactions:A GA²LEN position paper

Author

Zuberbier, Torsten, Dörr, Tamara, Aberer, Werner, Alvaro, Montserrat, Angier, Elizabeth, Arasi, Stefania, Arshad, Hasan, Ballmer-Weber, Barbara, Bartra, Joan, Beck, Lisa, Bégin, Philippe, Bindslev-Jensen, Carsten, Bislimovska, Jovanka, Bousquet, Jean, Brockow, Knut, Bush, Andrew, Cianferoni, Antonella, Cork, Michael J., Custovic, Adnan, Darsow, Ulf, de Jong, Nicolette, Deleanu, Diana, Del Giacco, Stefano, Deschildre, Antoine, Dunn Galvin, Audrey, Ebisawa, Motohiro, Fernández-Rivas, Montserrat, Ferrer, Marta, Fiocchi, Alessandro, Gerth van Wijk, Roy, Gotua, Maia, Grimshaw, Kate, Grünhagen, Josefine, Heffler, Enrico, Hide, Michihiro, Hoffmann-Sommergruber, Karin, Incorvaia, Cristoforo, Janson, Christer, Malte John, Swen, Jones, Carla, Jutel, Marek, Katoh, Norito, Kendziora, Benjamin, Kinaciyan, Tamar, Knol, Edward, Kurbacheva, Oksana, Lau, Susanne, Loh, Richard, Lombardi, Carlo, Mäkelä, Mika, Marchisotto, Mary Jane, Makris, Michael, Maurer, Marcus, Meyer, Rosan, Mijakoski, Dragan, Minov, Jordan, Mullol, Joaquim, Nilsson, Caroline, Nowak–Wegrzyn, Anna, Nwaru, Bright I., Odemyr, Mikela, Pajno, Giovanni Battista, Paudel, Sushil, Papadopoulos, Nikolaos G., Renz, Harald, Ricci, Giampaolo, Ring, Johannes, Rogala, Barbara, Sampson, Hugh, Senna, Gianenrico, Sitkauskiene, Brigita, Smith, Peter Kenneth, Stevanovic, Katarina, Stoleski, Sasho, Szajewska, Hania, Tanaka, Akio, Todo-Bom, Ana, Topal, Fatih Alexander, Valovirta, Erkka, Van Ree, Ronald, Venter, Carina, Wöhrl, Stefan, Wong, Gary W.K., Zhao, Zuotao, Worm, Margitta, Zuberbier, Torsten, Dörr, Tamara, Aberer, Werner, Alvaro, Montserrat, Angier, Elizabeth, Arasi, Stefania, Arshad, Hasan, Ballmer-Weber, Barbara, Bartra, Joan, Beck, Lisa, Bégin, Philippe, Bindslev-Jensen, Carsten, Bislimovska, Jovanka, Bousquet, Jean, Brockow, Knut, Bush, Andrew, Cianferoni, Antonella, Cork, Michael J., Custovic, Adnan, Darsow, Ulf, de Jong, Nicolette, Deleanu, Diana, Del Giacco, Stefano, Deschildre, Antoine, Dunn Galvin, Audrey, Ebisawa, Motohiro, Fernández-Rivas, Montserrat, Ferrer, Marta, Fiocchi, Alessandro, Gerth van Wijk, Roy, Gotua, Maia, Grimshaw, Kate, Grünhagen, Josefine, Heffler, Enrico, Hide, Michihiro, Hoffmann-Sommergruber, Karin, Incorvaia, Cristoforo, Janson, Christer, Malte John, Swen, Jones, Carla, Jutel, Marek, Katoh, Norito, Kendziora, Benjamin, Kinaciyan, Tamar, Knol, Edward, Kurbacheva, Oksana, Lau, Susanne, Loh, Richard, Lombardi, Carlo, Mäkelä, Mika, Marchisotto, Mary Jane, Makris, Michael, Maurer, Marcus, Meyer, Rosan, Mijakoski, Dragan, Minov, Jordan, Mullol, Joaquim, Nilsson, Caroline, Nowak–Wegrzyn, Anna, Nwaru, Bright I., Odemyr, Mikela, Pajno, Giovanni Battista, Paudel, Sushil, Papadopoulos, Nikolaos G., Renz, Harald, Ricci, Giampaolo, Ring, Johannes, Rogala, Barbara, Sampson, Hugh, Senna, Gianenrico, Sitkauskiene, Brigita, Smith, Peter Kenneth, Stevanovic, Katarina, Stoleski, Sasho, Szajewska, Hania, Tanaka, Akio, Todo-Bom, Ana, Topal, Fatih Alexander, Valovirta, Erkka, Van Ree, Ronald, Venter, Carina, Wöhrl, Stefan, Wong, Gary W.K., Zhao, Zuotao, and Worm, Margitta

Abstract

Background: Food anaphylaxis is commonly elicited by unintentional ingestion of foods containing the allergen above the tolerance threshold level of the individual. While labeling the 14 main allergens used as ingredients in food products is mandatory in the EU, there is no legal definition of declaring potential contaminants. Precautionary allergen labeling such as “may contain traces of” is often used. However, this is unsatisfactory for consumers as they get no information if the contamination is below their personal threshold. In discussions with the food industry and technologists, it was suggested to use a voluntary declaration indicating that all declared contaminants are below a threshold of 0.5 mg protein per 100 g of food. This concentration is known to be below the threshold of most patients, and it can be technically guaranteed in most food production. However, it was also important to assess that in case of accidental ingestion of contaminants below this threshold by highly allergic patients, no fatal anaphylactic reaction could occur. Therefore, we performed a systematic review to assess whether a fatal reaction to 5mg of protein or less has been reported, assuming that a maximum portion size of 1kg of a processed food exceeds any meal and thus gives a sufficient safety margin. Methods: MEDLINE and EMBASE were searched until 24 January 2021 for provocation studies and case reports in which one of the 14 major food allergens was reported to elicit fatal or life-threatening anaphylactic reactions and assessed if these occurred below the ingestion of 5mg of protein. A Delphi process was performed to obtain an expert consensus on the results. Results: In the 210 studies included, in our search, no reports of fatal anaphylactic reactions reported below 5 mg protein ingested were identified. However, in provocation studies and case reports, severe reactions below 5 mg were reported for the following allergens: eggs, fish, lupin, milk, nuts, peanuts, soy

Published
2022

154. Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food—A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA²LEN position paper

Author

CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Zuberbier, Torsten, Dörr, Tamara, Aberer, Werner, Alvaro, Montserrat, Angier, Elizabeth, Arasi, Stefania, Arshad, Hasan, Ballmer-Weber, Barbara, Bartra, Joan, Beck, Lisa, Bégin, Philippe, Bindslev-Jensen, Carsten, Bislimovska, Jovanka, Bousquet, Jean, Brockow, Knut, Bush, Andrew, Cianferoni, Antonella, Cork, Michael J, Custovic, Adnan, Darsow, Ulf, de Jong, Nicolette, Deleanu, Diana, Del Giacco, Stefano, Deschildre, Antoine, Dunn Galvin, Audrey, Ebisawa, Motohiro, Fernández-Rivas, Montserrat, Ferrer, Marta, Fiocchi, Alessandro, Gerth van Wijk, Roy, Gotua, Maia, Grimshaw, Kate, Grünhagen, Josefine, Heffler, Enrico, Hide, Michihiro, Hoffmann-Sommergruber, Karin, Incorvaia, Cristoforo, Janson, Christer, Malte John, Swen, Jones, Carla, Jutel, Marek, Katoh, Norito, Kendziora, Benjamin, Kinaciyan, Tamar, Knol, Edward, Kurbacheva, Oksana, Lau, Susanne, Loh, Richard, Lombardi, Carlo, Mäkelä, Mika, Marchisotto, Mary Jane, Makris, Michael, Maurer, Marcus, Meyer, Rosan, Mijakoski, Dragan, Minov, Jordan, Mullol, Joaquim, Nilsson, Caroline, Nowak-Wegrzyn, Anna, Nwaru, Bright I, Odemyr, Mikela, Pajno, Giovanni Battista, Paudel, Sushil, Papadopoulos, Nikolaos G, Renz, Harald, Ricci, Giampaolo, Ring, Johannes, Rogala, Barbara, Sampson, Hugh, Senna, Gianenrico, Sitkauskiene, Brigita, Smith, Peter Kenneth, Stevanovic, Katarina, Stoleski, Sasho, Szajewska, Hania, Tanaka, Akio, Todo-Bom, Ana, Topal, Fatih Alexander, Valovirta, Erkka, Van Ree, Ronald, Venter, Carina, Wöhrl, Stefan, Wong, Gary W K, Zhao, Zuotao, Worm, Margitta, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Zuberbier, Torsten, Dörr, Tamara, Aberer, Werner, Alvaro, Montserrat, Angier, Elizabeth, Arasi, Stefania, Arshad, Hasan, Ballmer-Weber, Barbara, Bartra, Joan, Beck, Lisa, Bégin, Philippe, Bindslev-Jensen, Carsten, Bislimovska, Jovanka, Bousquet, Jean, Brockow, Knut, Bush, Andrew, Cianferoni, Antonella, Cork, Michael J, Custovic, Adnan, Darsow, Ulf, de Jong, Nicolette, Deleanu, Diana, Del Giacco, Stefano, Deschildre, Antoine, Dunn Galvin, Audrey, Ebisawa, Motohiro, Fernández-Rivas, Montserrat, Ferrer, Marta, Fiocchi, Alessandro, Gerth van Wijk, Roy, Gotua, Maia, Grimshaw, Kate, Grünhagen, Josefine, Heffler, Enrico, Hide, Michihiro, Hoffmann-Sommergruber, Karin, Incorvaia, Cristoforo, Janson, Christer, Malte John, Swen, Jones, Carla, Jutel, Marek, Katoh, Norito, Kendziora, Benjamin, Kinaciyan, Tamar, Knol, Edward, Kurbacheva, Oksana, Lau, Susanne, Loh, Richard, Lombardi, Carlo, Mäkelä, Mika, Marchisotto, Mary Jane, Makris, Michael, Maurer, Marcus, Meyer, Rosan, Mijakoski, Dragan, Minov, Jordan, Mullol, Joaquim, Nilsson, Caroline, Nowak-Wegrzyn, Anna, Nwaru, Bright I, Odemyr, Mikela, Pajno, Giovanni Battista, Paudel, Sushil, Papadopoulos, Nikolaos G, Renz, Harald, Ricci, Giampaolo, Ring, Johannes, Rogala, Barbara, Sampson, Hugh, Senna, Gianenrico, Sitkauskiene, Brigita, Smith, Peter Kenneth, Stevanovic, Katarina, Stoleski, Sasho, Szajewska, Hania, Tanaka, Akio, Todo-Bom, Ana, Topal, Fatih Alexander, Valovirta, Erkka, Van Ree, Ronald, Venter, Carina, Wöhrl, Stefan, Wong, Gary W K, Zhao, Zuotao, and Worm, Margitta

Published
2022

155. Major Allergen Content in Allergen Immunotherapy Products: The Limited Value of Numbers

Author

Becker, S, Fassio, F, Muñoz-Cano, R, Klimek, Ludger; https://orcid.org/0000-0002-2455-0192, Vidal, C, Heath, M D, Kündig, T M, Vogelberg, C, Toran, C, Jensen-Jarolim, E; https://orcid.org/0000-0003-4019-5765, Heffler, Enrico; https://orcid.org/0000-0002-0492-5663, Tomazic, P V; https://orcid.org/0000-0001-6445-4800, Feindor, M, Hewings, S, Carreno, T, Morales, M, Mösges, R; https://orcid.org/0000-0002-1928-810X, Skinner, M A, Graessel, A, Hernandez, D, Kramer, M F, Becker, S, Fassio, F, Muñoz-Cano, R, Klimek, Ludger; https://orcid.org/0000-0002-2455-0192, Vidal, C, Heath, M D, Kündig, T M, Vogelberg, C, Toran, C, Jensen-Jarolim, E; https://orcid.org/0000-0003-4019-5765, Heffler, Enrico; https://orcid.org/0000-0002-0492-5663, Tomazic, P V; https://orcid.org/0000-0001-6445-4800, Feindor, M, Hewings, S, Carreno, T, Morales, M, Mösges, R; https://orcid.org/0000-0002-1928-810X, Skinner, M A, Graessel, A, Hernandez, D, and Kramer, M F

Abstract

The prevalence of allergic disorders has increased drastically over the last 50 years to the extent that they can be considered epidemic. At present, allergen-specific immunotherapy (AIT) is the only therapy that targets the underlying cause of allergic disorders, and evidence of its superiority is based on data accumulated from clinical trials and observational studies demonstrating efficacy and safety. However, several aspects remain unresolved, such as harmonization and standardization of manufacturing and quantification procedures across manufacturers, homogeneous reporting of strength, and the establishment of international reference standards for many allergens. This article discusses issues related to the measurement of major allergen content in AIT extracts, raising the question of whether comparison of products from different manufacturers is an appropriate basis for selecting a specific AIT product. Allergen standardization in immunotherapy products is critical for ensuring quality and, thereby, safety and efficacy. However, lack of harmonization in manufacturing processes, allergen quantification (methodologies and references), national regulatory differences, clinical practice, and labeling shows that the comparison of AIT products based solely on major allergen amounts is not rational and, in fact, impossible. Moreover, when rating the information given for a specific product, it is necessary to take into account further inherent characteristics of products and their application in clinical practice, such as the state of extract modification, addition of adjuvant or adjuvant system, route of administration (sublingual/ subcutaneous), and cumulative dose as per posology (including the volume per administration). Finally, only convincing clinical data can serve as the basis for product-specific evaluation and cross-product comparability of individual products.

Published
2022

157. Polyethylene Glycol and Polysorbate 80 Skin Tests in the Context of an Allergic Risk Assessment for Hypersensitivity Reactions to Anti-SARS-CoV-2 mRNA Vaccines.

Author

Nappi, Emanuele, Racca, Francesca, Piona, Alessandra, Messina, Maria Rita, Ferri, Sebastian, Lamacchia, Donatella, Cataldo, Giuseppe, Costanzo, Giovanni, Del Moro, Lorenzo, Puggioni, Francesca, Canonica, Giorgio Walter, Heffler, Enrico, and Paoletti, Giovanni

Subjects
POLYSORBATE 80, SKIN tests, POLYETHYLENE glycol, RISK assessment, ALLERGIES, HEPATITIS B
Abstract

Concern has arisen about hypersensitivity reactions in patients with allergic reactions to drugs containing polyethylene glycol (PEG) or polysorbate 80 (PS80), excipients of currently available anti-SARS-CoV-2 mRNA vaccines. However, the actual utility of PEG and PS80 skin allergy testing is currently still debated. We retrospectively analyzed all cases of patients on whom we performed allergometric skin tests for PEG and PS80 in the context of a pre-vaccination screening (for patients with multiple hypersensitivity reactions to drugs for which these excipients were among the suspected agents) or following suspected hypersensitivity reactions to anti-SARS-CoV-2 vaccines. A total of 134 tests were performed for PEG and PS80, eight of which produced uninterpretable results (due to dermographism or non-specific reactions). Of the remaining 126 cases (85 pre-vaccinal and 41 post-vaccine reactions), 16 (12.7%) were positive for PEG and/or PS80. Stratifying by clinical indication, there were no statistically significant differences in the proportion of positive tests between patients evaluated in the context of the pre-vaccination screening and those evaluated after a vaccine reaction (10.6% vs. 17.1%, respectively, p = 0.306). Allergometric skin tests for PEG and PS80 in our case series resulted positive in an unexpectedly high proportion of patients, suggesting that testing for allergy to these two excipients should not be ignored in case of reasonable clinical suspicion. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

158. Use, Abuse, and Misuse of Nasal Medications: Real-Life Survey on Community Pharmacist's Perceptions.

Author

Russo, Elena, Giombi, Francesco, Paoletti, Giovanni, Heffler, Enrico, Canonica, Giorgio Walter, Pirola, Francesca, Mercante, Giuseppe, Spriano, Giuseppe, Malvezzi, Luca, Keber, Enrico, SGCP, and Giua, Corrado

Subjects
PHARMACISTS' attitudes, INTRANASAL medication, MEDICATION abuse, ALLERGIC rhinitis, SOCIALIZATION, INTELLIGIBILITY of speech
Abstract

Background: Medication overuse is an increasing global problem, especially for those rhinology diseases whose management requires over-the-counter drugs. This observational community pharmacy-based study aimed to investigate the actual use of the best-selling topical nasal medications and to characterize the clinical issues underlying their query through the pharmacist's perception. Methods: In the pilot phase, a preliminary survey was developed by a team of researchers and tested on a small sample of practitioners to assess usability and intelligibility. Eventual amendments were made according to the feedback obtained, and the final version was submitted to practitioners working in 376 pharmacies evenly distributed over the Italian territory. Results: Two groups of customers (18–30 years old and 60–75 years old) were the ones who most frequently purchased topical decongestants. The dosage applied for sympathomimetic amines was higher than recommended in up to 44.4% and the duration of use longer than 5 days in up to 31.9% of the cases. Patients' queries of alpha agonists and topical corticosteroids resulted in significantly higher numbers than practitioners' prescriptions. Allergic rhinitis was the most common disease affecting patients seeking sympathomimetic amines. Conclusions: The prolonged use of sympathomimetic amines in patients suffering from rhinology diseases is a significant problem that requires greater attention in terms of social education and surveillance. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

159. Personalized Management of Patients with Chronic Rhinosinusitis with Nasal Polyps in Clinical Practice: A Multidisciplinary Consensus Statement

Author

De Corso, Eugenio, primary, Bilò, Maria Beatrice, additional, Matucci, Andrea, additional, Seccia, Veronica, additional, Braido, Fulvio, additional, Gelardi, Matteo, additional, Heffler, Enrico, additional, Latorre, Manuela, additional, Malvezzi, Luca, additional, Pelaia, Girolamo, additional, Senna, Gianenrico, additional, Castelnuovo, Paolo, additional, and Canonica, Giorgio Walter, additional

Published
2022
Full Text
View/download PDF

160. Small Airways: The “Silent Zone” of 2021 GINA Report?

Author

Cottini, Marcello, primary, Lombardi, Carlo, additional, Passalacqua, Giovanni, additional, Bagnasco, Diego, additional, Berti, Alvise, additional, Comberiati, Pasquale, additional, Imeri, Gianluca, additional, Landi, Massimo, additional, and Heffler, Enrico, additional

Published
2022
Full Text
View/download PDF

162. New Onset of Eosinophilic Granulomatosis with Polyangiitis Following mRNA-Based COVID-19 Vaccine

Author

Nappi, Emanuele, primary, De Santis, Maria, additional, Paoletti, Giovanni, additional, Pelaia, Corrado, additional, Terenghi, Fabrizia, additional, Pini, Daniela, additional, Ciccarelli, Michele, additional, Selmi, Carlo Francesco, additional, Puggioni, Francesca, additional, Canonica, Giorgio Walter, additional, and Heffler, Enrico, additional

Published
2022
Full Text
View/download PDF

164. Efficacy and safety of benralizumab in chronic rhinosinusitis with nasal polyps: A randomized, placebo-controlled trial

Author

Bachert, Claus, primary, Han, Joseph K., additional, Desrosiers, Martin Y., additional, Gevaert, Philippe, additional, Heffler, Enrico, additional, Hopkins, Claire, additional, Tversky, Jody R., additional, Barker, Peter, additional, Cohen, David, additional, Emson, Claire, additional, Martin, Ubaldo J., additional, Shih, Vivian H., additional, Necander, Sofia, additional, Kreindler, James L., additional, Jison, Maria, additional, and Werkström, Viktoria, additional

Published
2022
Full Text
View/download PDF

165. The effect of the COVID-19 pandemic on severe asthma care in Europe: will care change for good?

Author

Eger, Katrien, primary, Paroczai, Dora, additional, Bacon, Alison, additional, Schleich, Florence, additional, Sergejeva, Svetlana, additional, Bourdin, Arnaud, additional, Vachier, Isabelle, additional, Zervas, Eleftherios, additional, Katsoulis, Konstantinos, additional, Papapetrou, Dimosthenis, additional, Kostikas, Konstantinos, additional, Csoma, Zsuzsanna, additional, Heffler, Enrico, additional, Canonica, Giorgio Walter, additional, Grisle, Ineta, additional, Bieksiene, Kristina, additional, Palacionyte, Jolita, additional, ten Brinke, Anneke, additional, Hashimoto, Simone, additional, Smeenk, Frank W.J.M., additional, Braunstahl, Gert-Jan, additional, van der Sar, Simone, additional, Mihălţan, Florin, additional, Nenasheva, Natalia, additional, Peredelskaya, Marina, additional, Zvezdin, Biljana, additional, Čekerevac, Ivan, additional, Hromiš, Sanja, additional, Ćupurdija, Vojislav, additional, Lazic, Zorica, additional, Milenkovic, Branislava, additional, Dimic-Janjic, Sanja, additional, Yasinska, Valentyna, additional, Dahlén, Barbro, additional, Bossios, Apostolos, additional, Lazarinis, Nikolaos, additional, Aronsson, David, additional, Egesten, Arne, additional, Munir, Abul Kashem Mohammad, additional, Ahlbeck, Lars, additional, Janson, Christer, additional, Škrgat, Sabina, additional, Edelbaher, Natalija, additional, Leuppi, Joerg, additional, Jaun, Fabienne, additional, Rüdiger, Jochen, additional, Pavlov, Nikolay, additional, Gianella, Pietro, additional, Fischer, Reta, additional, Charbonnier, Florian, additional, Chaudhuri, Rekha, additional, Smith, Steven James, additional, Doe, Simon, additional, Fawdon, Michelle, additional, Masoli, Matthew, additional, Heaney, Liam, additional, Haitchi, Hans Michael, additional, Kurukulaaratchy, Ramesh, additional, Fulton, Olivia, additional, Frankemölle, Betty, additional, Gibson, Toni, additional, Needham, Karen, additional, Howarth, Peter, additional, Djukanovic, Ratko, additional, Bel, Elisabeth, additional, and Hyland, Michael, additional

Published
2022
Full Text
View/download PDF

166. Fungal exposome, human health and unmet needs: a 2022 update with special focus on allergy

Author

Vitte, Joana, primary, Michel, Moïse, additional, Malinovschi, Andrei, additional, Caminati, Marco, additional, Odebode, Adeyinka, additional, Annesi-Maesano, Isabella, additional, Caimmi, Davide, additional, Cassagne, Carole, additional, Demoly, Pascal, additional, Heffler, Enrico, additional, Menu, Estelle, additional, Nwaru, Bright, additional, Sereme, Youssouf, additional, Ranque, Stéphane, additional, Raulf, Monika, additional, Feleszko, Wojciech, additional, Janson, Christer, additional, and Galán, Carmen, additional

Published
2022
Full Text
View/download PDF

168. sj-doc-1-ajr-10.1177_19458924221112211 - Supplemental material for Efficacy and Safety of Dupilumab Versus Omalizumab in Chronic Rhinosinusitis With Nasal Polyps and Asthma: EVEREST Trial Design

Author

De Prado Gomez, Lucia, Khan, Asif H., Peters, Anju T., Bachert, Claus, Wagenmann, Martin, Heffler, Enrico, Hopkins, Claire, Hellings, Peter W., Zhang, Mei, Xing, Jun, Rowe, Paul, and Jacob-Nara, Juby A.

Subjects
110315 Otorhinolaryngology, FOS: Clinical medicine
Abstract

Supplemental material, sj-doc-1-ajr-10.1177_19458924221112211 for Efficacy and Safety of Dupilumab Versus Omalizumab in Chronic Rhinosinusitis With Nasal Polyps and Asthma: EVEREST Trial Design by Lucia De Prado Gomez, PharmD, MSc, Asif H. Khan, MBBS, MPH, Anju T. Peters, MD, Claus Bachert, MD, PhD, Martin Wagenmann, MD, Enrico Heffler, MD, PhD, Claire Hopkins, BMBCh, Peter W. Hellings, MD, PhD, Mei Zhang, PhD, Jun Xing, PhD, Paul Rowe, MD, Juby A. Jacob-Nara, MD, MPH and DHSc in American Journal of Rhinology & Allergy

Published
2022
Full Text
View/download PDF

169. Personalized medicine for allergy treatment: Allergen immunotherapy still a unique and unmatched model

Author

Incorvaia, Cristoforo, Al‐Ahmad, Mona, Ansotegui, Ignacio J, Arasi, Stefania, Bachert, Claus, Bos, Catherine, Bousquet, Jean, Bozek, Andrzéj, Caimmi, Davide, Calderón, Moises A, Casale, Thomas, Custovic, Adnan, De Blay, Frédéric, Demoly, Pascal, Devillier, Philippe, Didier, Alain, Fiocchi, Alessandro, Fox, Adam T, Gevaert, Philippe, Gomez, Maximiliano, Heffler, Enrico, Ilina, Natalia, Irani, Carla, Jutel, Marek, Karagiannis, Efstrathios, Klimek, Ludger, Kuna, Piotr, O'Hehir, Robin, Kurbacheva, Oxana, Matricardi, Paolo M, et al, Schmid-Grendelmeier, Peter, University of Zurich, and Heffler, Enrico

Subjects
2403 Immunology, Immunology, 2723 Immunology and Allergy, 10177 Dermatology Clinic, Immunology and Allergy, 610 Medicine & health
Published
2021

171. Chronic cough and irritable larynx

Author

Bucca, Caterina B., Bugiani, Massimiliano, Culla, Beatrice, Guida, Giuseppe, Heffler, Enrico, Mietta, Sabrina, Moretto, Antonella, Rolla, Giovanni, and Brussino, Luisa

Published
2011
Full Text
View/download PDF

174. Nasal Polyposis Quality of Life (NPQ): Development and Validation of the First Specific Quality of Life Questionnaire for Chronic Rhinosinusitis with Nasal Polyps

Author

Baiardini, Ilaria, primary, Paoletti, Giovanni, additional, Mariani, Alessia, additional, Malvezzi, Luca, additional, Pirola, Francesca, additional, Spriano, Giuseppe, additional, Mercante, Giuseppe, additional, Puggioni, Francesca, additional, Racca, Francesca, additional, Melone, Giulio, additional, Malipiero, Giacomo, additional, Ferri, Sebastian, additional, Canonica, Giorgio Walter, additional, and Heffler, Enrico, additional

Published
2022
Full Text
View/download PDF

175. Responder analysis to demonstrate the effect of targeting type 2 inflammatory mechanisms with dupilumab across objective and patient‐reported endpoints for patients with severe chronic rhinosinusitis with nasal polyps in the SINUS‐24 and SINUS‐52 studies

Author

Bachert, Claus, primary, Peters, Anju T., additional, Heffler, Enrico, additional, Han, Joseph K., additional, Olze, Heidi, additional, Pfaar, Oliver, additional, Chuang, Chien‐Chia, additional, Rout, Raj, additional, Attre, Richa, additional, Goga, Ledia, additional, Jacob‐Nara, Juby A., additional, Rowe, Paul J., additional, Deniz, Yamo, additional, Chen, Zhen, additional, Kamat, Siddhesh, additional, and Siddiqui, Shahid, additional

Published
2022
Full Text
View/download PDF

177. Biologics in Severe Eosinophilic Asthma: Three-Year Follow-Up in a SANI Single Center

Author

Solidoro, Paolo, primary, Nicola, Stefania, additional, Ridolfi, Irene, additional, Canonica, Giorgio Walter, additional, Blasi, Francesco, additional, Paggiaro, Pierluigi, additional, Heffler, Enrico, additional, Bagnasco, Diego, additional, Patrucco, Filippo, additional, Ribolla, Fulvia, additional, Bucca, Caterina, additional, Rolla, Giovanni, additional, Albera, Carlo, additional, and Brussino, Luisa, additional

Published
2022
Full Text
View/download PDF

178. Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets

Author

Racca, Francesca, primary, Pellegatta, Gaia, additional, Cataldo, Giuseppe, additional, Vespa, Edoardo, additional, Carlani, Elisa, additional, Pelaia, Corrado, additional, Paoletti, Giovanni, additional, Messina, Maria Rita, additional, Nappi, Emanuele, additional, Canonica, Giorgio Walter, additional, Repici, Alessandro, additional, and Heffler, Enrico, additional

Published
2022
Full Text
View/download PDF

179. Allergic patients during the COVID‐19 pandemic—Clinical practical considerations: An European Academy of Allergy and Clinical Immunology survey

Author

Alvaro‐Lozano, Montserrat, primary, Sandoval‐Ruballos, Mónica, additional, Giovannini, Mattia, additional, Jensen‐Jarolim, Erika, additional, Sahiner, Umit, additional, Tomic Spiric, Vesna, additional, Quecchia, Cristina, additional, Chaker, Adam, additional, Heffler, Enrico, additional, Klimek, Ludger, additional, Brough, Helen, additional, Sturm, Gunter, additional, Untersmayr, Eva, additional, Bonini, Mateo, additional, and Pfaar, Oliver, additional

Published
2022
Full Text
View/download PDF

180. Estimating Clinically Meaningful Change of Efficacy Outcomes in Inadequately Controlled Chronic Rhinosinusitis with Nasal Polyposis

Author

Han, Joseph K., primary, Bachert, Claus, additional, Lee, Stella E., additional, Hopkins, Claire, additional, Heffler, Enrico, additional, Hellings, Peter W., additional, Peters, Anju T., additional, Kamat, Siddhesh, additional, Whalley, Diane, additional, Qin, Shanshan, additional, Nelson, Lauren, additional, Siddiqui, Shahid, additional, Khan, Asif H., additional, Li, Yongtao, additional, Mannent, Leda P., additional, Guillemin, Isabelle, additional, and Chuang, Chien‐Chia, additional

Published
2021
Full Text
View/download PDF

181. Eosinophilic and Noneosinophilic Asthma: An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort

Author

Heaney, Liam G., Perez de Llano, Luis, Al-Ahmad, Mona, Backer, Vibeke, Busby, John, Canonica, Giorgio Walter, Christoff, George C., Cosio, Borja G., FitzGerald, J. Mark, Heffler, Enrico, Iwanaga, Takashi, Jackson, David J., Menzies-Gow, Andrew N., Papadopoulos, Nikolaos G., Papaioannou, Andriana I., Pfeffer, Paul E., Popov, Todor A., Porsbjerg, Celeste M., Rhee, Chin Kook, Sadatsafavi, Mohsen, Tohda, Yuji, Wang, Eileen, Wechsler, Michael E., Alacqua, Marianna, Altraja, Alan, Bjermer, Leif, Björnsdóttir, Unnur S., Bourdin, Arnaud, Brusselle, Guy G., Buhl, Roland, Costello, Richard W., Hew, Mark, Koh, Mariko Siyue, Lehmann, Sverre, Lehtimäki, Lauri, Peters, Matthew, Taillé, Camille, Taube, Christian, Tran, Trung N., Zangrilli, James, Bulathsinhala, Lakmini, Carter, Victoria A., Chaudhry, Isha, Eleangovan, Neva, Hosseini, Naeimeh, Kerkhof, Marjan, Murray, Ruth B., Price, Chris A., Price, David B., Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Epidemiology, Tampere University, Department of Respiratory medicine, Dermatology and Allergology, and Clinical Medicine

Subjects
PROTOCOL, Adult, Male, Asia, [SDV]Life Sciences [q-bio], Medizin, 3121 Internal medicine, Global Health, Severity of Illness Index, VALIDATION, International Severe Asthma Registry, MECHANISMS, Cohort Studies, Leukocyte Count, Middle East, Adrenal Cortex Hormones, Eosinophilia, Medicine and Health Sciences, Prevalence, Humans, Anti-Asthmatic Agents, Registries, Age of Onset, PREDICTORS, ComputingMilieux_MISCELLANEOUS, RECEPTOR, BENRALIZUMAB, Middle Aged, Asthma, Patient Care Management, Respiratory Function Tests, Eosinophils, Europe, Biological Variation, Population, North America, Female, FENO
Abstract

Background: Phenotypic characteristics of patients with eosinophilic and noneosinophilic asthma are not well characterized in global, real-life severe asthma cohorts. Research Question: What is the prevalence of eosinophilic and noneosinophilic phenotypes in the population with severe asthma, and can these phenotypes be differentiated by clinical and biomarker variables? Study Design and Methods: This was an historical registry study. Adult patients with severe asthma and available blood eosinophil count (BEC) from 11 countries enrolled in the International Severe Asthma Registry (January 1, 2015-September 30, 2019) were categorized according to likelihood of eosinophilic phenotype using a predefined gradient eosinophilic algorithm based on highest BEC, long-term oral corticosteroid use, elevated fractional exhaled nitric oxide, nasal polyps, and adult-onset asthma. Demographic and clinical characteristics were defined at baseline (ie, 1 year before or closest to date of BEC). Results: One thousand seven hundred sixteen patients with prospective data were included; 83.8% were identified as most likely (grade 3), 8.3% were identified as likely (grade 2), and 6.3% identified as least likely (grade 1) to have an eosinophilic phenotype, and 1.6% of patients showed a noneosinophilic phenotype (grade 0). Eosinophilic phenotype patients (ie, grades 2 or 3) showed later asthma onset (29.1 years vs 6.7 years; P < .001) and worse lung function (postbronchodilator % predicted FEV1, 76.1% vs 89.3%; P = .027) than those with a noneosinophilic phenotype. Patients with noneosinophilic phenotypes were more likely to be women (81.5% vs 62.9%; P = .047), to have eczema (20.8% vs 8.5%; P = .003), and to use anti-IgE (32.1% vs 13.4%; P = .004) and leukotriene receptor antagonists (50.0% vs 28.0%; P = .011) add-on therapy. Interpretation: According to this multicomponent, consensus-driven, and evidence-based eosinophil gradient algorithm (using variables readily accessible in real life), the severe asthma eosinophilic phenotype was more prevalent than previously identified and was phenotypically distinct. This pragmatic gradient algorithm uses variables readily accessible in primary and specialist care, addressing inherent issues of phenotype heterogeneity and phenotype instability. Identification of treatable traits across phenotypes should improve therapeutic precision. publishedVersion

Published
2021

184. Local Allergic Rhinitis: Lights and Shadows of a Mysterious Entity.

Author

Melone, Giulio, Giorgis, Veronica, Di Pino, Marina, Pelaia, Corrado, Nappi, Emanuele, Heffler, Enrico, Landi, Massimo, Gelardi, Matteo, and Paoletti, Giovanni

Subjects
ALLERGIC rhinitis, JOB classification, CYTOLOGY, IMMUNOGLOBULIN E, PEANUT allergy, SKIN tests
Abstract

Local allergic rhinitis (LAR) is, to date, a debated and complex entity, still orphan of global consideration and a multicentric approach. LAR does not seem to find a proper positioning in the classic classifications and phenotypes of chronic rhinitis, and its pathophysiology relies specifically on the presence of local IgE. These patients in fact have a suggestive clinical history of allergic rhinitis in the presence of negative skin prick tests and serum IgE tests for the suspect allergen. Nasal allergen challenge, assessment of local IgE, basophil activation test (BAT), and nasal cytology are, at the moment, the most used tests in the diagnostic approach to the disease, despite their limitations. Considering that the correct interpretation of diagnostic tests and their clinical relevance is fundamental in the assessment of the right diagnosis and the subsequent therapy, we propose a new diagnostic approach that encompasses all of these methodologies and suggest that several pragmatic randomized control trials as well as prospective, multicentric studies directed at the long-term follow-up of LAR be carried out to further investigate this debated entity. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

185. ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments

Author

Lombardi, Carlo, Asero, Riccardo, Bagnasco, Diego, Blasi, Francesco, Bonini, Matteo, Bussi, Mario, Canevari, Rikki F., Canonica, Giorgio Walter, Castelnuovo, Paolo, Cecchi, Lorenzo, Cosmi, Lorenzo, Gelardi, Matteo, Heffler, Enrico, Indinnimeo, Luciana, Landi, Massimo, Licari, Amelia, Liotta, Francesco, Macchi, Alberto, Malvezzi, Luca, Marseglia, Gianluigi, Micheletto, Claudio, Musarra, Antonino, Peroni, Diego, Piacentini, Giorgio, Poletti, Venerino, Richeldi, Luca, Santoni, Angela, Schiappoli, Michele, Senna, Gianenrico, Vaghi, Adriano, Villani, Alberto, and Passalacqua, Giovanni

Published
2021
Full Text
View/download PDF

189. ARIA‐EAACI care pathways for allergen immunotherapy in respiratory allergy

Author

Bousquet, Jean, Pfaar, Oliver, Agache, Ioana, Bedbrook, Anna, Akdis, Cezmi A, Canonica, Giorgio Walter, Chivato, Tomas, Al-Ahmad, Mona, Rasib, A. H. Abdul, Ansotegui, Ignacio J, Bachert, Claus, Soto-Martinez, Manuel, Laune, Daniel, Casale, Tomas, Levin, Michael, Larenas-Linnemann, Désirée, Samolinski, Boleslaw, Lodrup Carlsen, Karin C, O'Mahony, Liam, Lombardi, Carlo, Riggioni, Carmen, Hossny, Elham, Barata, Luís Taborda, Lourenço, Olga, Devillier, Philippe, Mahboub, Bassam, Malling, Hans-Jørgen, Sheikh, Aziz, Manning, Patrick, Passalacqua, Giovanni, Marshall, Gailen D, Sanchez-Borges, Mario, Toppila-Salmi, Sanna, Melén, Erik, Fokkens, Wytske J, Meltzer, Eli O, Miculinic, Neven, Soto-Quiros, Manuel, Milenkovic, Branislava, Roberts, Graham, Ohta, Ken, Scichilone, Nicola, Moin, Mostafa, Odemyr, Mikaëla, Montefort, Stephen, Almeida, Mário Morais, Bom, Ana Todo, Mortz, Charlotte G, Serpa, Faradiba S, Patella, Vincenzo, Sova, Milan, Mösges, Ralph, Mullol, Joaquim, Namazova Baranova, Leyla, Tsiligianni, Ioanna, Neffen, Hugo, Bjermer, Leif, Rodriguez-Gonzales, Monica, Torres, Maria J, Okamoto, Yoshitaka, Okubo, Kimi, Pajno, Giovanni B, Baharuddin, Abdullah, Cecchi, Lorenzo, Sastre, Joaquin, Untersmayr, Eva, Pawankar, Ruby, Pham-Thi, Nhân, Plavec, Davor, Cardona, Victoria, Dokic, Dejan, Sisul, Juan Carlos, Rosario, Nelson, Rottem, Menachem, Rouadi, Philip W, Del Giacco, Stefano, Fonseca, Joao A, Schwarze, Jürgen, Scadding, Glenis K, Shamji, Mohamed H, Schmid-Grendelmeier, Peter, Niedoszytko, Marek, Valentin-Rostan, Marylin, Sofiev, Mikhail, Solé, Dirceu, Sooronbaev, Talant, Palkonen, Susanna, Urrutia-Pereira, Marilyn, Skypala, Isabel, Suppli-Ulrik, Charlotte, Bonini, Matteo, Popov, Todor A, Tomazic, Peter-Valentin, Valero, Antonio, Cepeda Sarabia, Alfonso M, Ryan, Dermot, Bosnic-Anticevich, Sinthia, Valiulis, Arunas, Durham, Stephen L, Schünemann, Holger, Kalayci, Omer, Valovirta, Erkka, Panzner, Petr, Vandenplas, Olivier, Ventura, Maria Teresa, Gotua, Maia, Vichyanond, Pakit, Chkhartishvili, Ekaterine, Wagenmann, Martin, Fontaine, Jean-François, Kull, Inger, Wallace, Dana, Recto, Marysia, Walusiak-Skorupa, Jolanta, Wang, De Yun, Hrubiško, Martin, Waserman, Susan, Ebisawa, Motohiro, Bosse, Isabelle, Grisle, Ineta, Wong, Gary Wk, Bindslev-Jensen, Carsten, Yorgancioglu, Arzu, Yusuf, Osman M, Khaitov, Musa, Zernotti, Mario, Gawlik, Radoslaw, Chu, Derek K, Irani, Carla, Zhang, Luo, Zidarn, Mihaela, Zuberbier, Torsten, Kuna, Piotr, Jutel, Marek, Guzmán, Maria Antonieta, El-Gamal, Yehia, Klimek, Ludger, Brough, Helen A, Brussino, Luisa, Calderon, Moises A, Caraballo, Luis, O'Hehir, Robyn E, Gelincik, Asli, Kvedariene, Violeta, Cirule, Ieva, Cruz, Alvaro A, Czarlewski, Wienczyslawa, Nekam, Kristof, Papadopoulos, Nikolaos G., Haahtela, Tari, Emuzyte, Regina, Gamkrelidze, Amiran, Fauquert, Jean Luc, Palomares, Oscar, Regateiro, Frederico S, Ivancevich, Juan Carlos, Gemicioglu, Bilun, Gereda, Jose E, Gerth van Wijk, Roy, Bergmann, Karl-Christian, Knol, Edward, Halken, Susanne, Heffler, Enrico, Hoffmann-Sommergruber, Karin, Martins, Pedro Carreiro, Kritikos, Vicky, Ispayeva, Zhanat, Julge, Kaja, Kaidashev, Igor, Demoly, Pascal, Kowalski, Marek, Kraxner, Helga, Ollert, Markus, Fiocchi, Alessandro, Lauerma, Antti, Lau, Susanne, Park, Hae-Sim, Gomez, R Maximiliano, Comprehensive Health Research Centre (CHRC) - pólo NMS, Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), uBibliorum, Bousquet J., Pfaar O., Agache I., Bedbrook A., Akdis C.A., Canonica G.W., Chivato T., Al-Ahmad M., Abdul Latiff A.H., Ansotegui I.J., Bachert C., Baharuddin A., Bergmann K.-C., Bindslev-Jensen C., Bjermer L., Bonini M., Bosnic-Anticevich S., Bosse I., Brough H.A., Brussino L., Calderon M.A., Caraballo L., Cardona V., Carreiro-Martins P., Casale T., Cecchi L., Cepeda Sarabia A.M., Chkhartishvili E., Chu D.K., Cirule I., Cruz A.A., Czarlewski W., del Giacco S., Demoly P., Devillier P., Dokic D., Durham S.L., Ebisawa M., El-Gamal✝ Y., Emuzyte R., Gamkrelidze A., Fauquert J.L., Fiocchi A., Fokkens W.J., Fonseca J.A., Fontaine J.-F., Gawlik R., Gelincik A., Gemicioglu B., Gereda J.E., Gerth van Wijk R., Gomez R.M., Gotua M., Grisle I., Guzman M.-A., Haahtela T., Halken S., Heffler E., Hoffmann-Sommergruber K., Hossny E., Hrubisko M., Irani C., Ivancevich J.C., Ispayeva Z., Julge K., Kaidashev I., Kalayci O., Khaitov M., Klimek L., Knol E., Kowalski M.L., Kraxner H., Kull I., Kuna P., Kvedariene V., Kritikos V., Lauerma A., Lau S., Laune D., Levin M., Larenas-Linnemann D.E., Lodrup Carlsen K.C., Lombardi C., Lourenco O.M., Mahboub B., Malling H.-J., Manning P., Marshall G.D., Melen E., Meltzer E.O., Miculinic N., Milenkovic B., Moin M., Montefort S., Morais-Almeida M., Mortz C.G., Mosges R., Mullol J., Namazova Baranova L., Neffen H., Nekam K., Niedoszytko M., Odemyr M., O'Hehir R.E., Ollert M., O'Mahony L., Ohta K., Okamoto Y., Okubo K., Pajno G.B., Palomares O., Palkonen S., Panzner P., G Papadopoulos N., Park H.-S., Passalacqua G., Patella V., Pawankar R., Pham-Thi N., Plavec D., Popov T.A., Recto M., Regateiro F.S., Riggioni C., Roberts G., Rodriguez-Gonzales M., Rosario N., Rottem M., Rouadi P.W., Ryan D., Samolinski B., Sanchez-Borges✝ M., Serpa F.S., Sastre J., Scadding G.K., Shamji M.H., Schmid-Grendelmeier P., Schunemann H.J., Sheikh A., Scichilone N., Sisul J.C., Sofiev M., Sole D., Sooronbaev T., Soto-Martinez M., Soto-Quiros M., Sova M., Schwarze J., Skypala I., Suppli-Ulrik C., Taborda-Barata L., Todo-Bom A., Torres M.J., Valentin-Rostan M., Tomazic P.-V., Valero A., Toppila-Salmi S., Tsiligianni I., Untersmayr E., Urrutia-Pereira M., Valiulis A., Valovirta E., Vandenplas O., Ventura M.T., Vichyanond P., Wagenmann M., Wallace D., Walusiak-Skorupa J., Wang D.Y., Waserman S., Wong G.W.K., Yorgancioglu A., Yusuf O.M., Zernotti M., Zhang L., Zidarn M., Zuberbier T., Jutel M., HUS Inflammation Center, Department of Dermatology, Allergology and Venereology, University of Helsinki, Department of Pathology, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Philipps Universität Marburg = Philipps University of Marburg, Transilvania University of Brasov, Universität Zürich [Zürich] = University of Zurich (UZH), Humanitas University [Milan] (Hunimed), Universidad San Pablo CEU, Kuwait University, Al-Rashed Allergy Center [Kuwait City], Pantai Hospital [Kuala Lumpur], Hospital Quirónsalud Bizkaia [Bilbao], Ghent University Hospital, Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Sun Yat-Sen University [Guangzhou] (SYSU), Universiti Sains Malaysia (USM), Humboldt University Of Berlin, Berlin Institute of Health (BIH), Odense University Hospital (OUH), Skane University Hospital [Lund], Fondazione Policlinico Universitario Agostino Gemelli IRCCS, National Heart and Lung Institute [London] (NHLI), Imperial College London-Royal Brompton and Harefield NHS Foundation Trust, Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Woolcock Institute of Medical Research [Sydney], The University of Sydney, Guy's and St Thomas' Hospital [London], King‘s College London, Università degli studi di Torino = University of Turin (UNITO), University of Cartagena, Vall d'Hebron University Hospital [Barcelona], Centro Hospitalar de Lisboa Central E.P.E, NOVA Medical School - Faculdade de Ciências Médicas (NMS), Universidade Nova de Lisboa = NOVA University Lisbon (NOVA)-Universidade Nova de Lisboa = NOVA University Lisbon (NOVA), University of South Florida [Tampa] (USF), Azienda Usl Toscana centro [Firenze], Universidad Simon Bolivar (USB), David Tvildiani Medical University (DTMU), McMaster University [Hamilton, Ontario], Children's Clinical University Hospital [Riga, Latvia] (CCUH), Universidade Federal da Bahia (UFBA), Università degli Studi di Cagliari = University of Cagliari (UniCa), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Hôpital Foch [Suresnes], Sagamihara National Hospital [Kanagawa, Japan], Université Ain Shams, Vilnius University [Vilnius], CHU Clermont-Ferrand, IRCCS Ospedale Pediatrico Bambino Gesù [Roma], Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA), European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Universidade do Porto = University of Porto, Silesian Medical University, Katowice, Poland, Cerrahpasa Faculty of Medicine, Istanbul University, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Universidad de Chile = University of Chile [Santiago] (UCHILE), Humanitas Clinical and Research Center [Rozzano, Milan, Italy], Medizinische Universität Wien = Medical University of Vienna, Hôtel-Dieu de France (HDF), Université Saint-Joseph de Beyrouth (USJ), Tartu University Hospital [Tartu, Estonia], Ukrainina Medical Stomatological Academy [Poltava, Ukraine], Hacettepe University = Hacettepe Üniversitesi, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Siriraj Hospital, Mahidol University, Mahidol University [Bangkok], Nova Southeastern University (NSU), Nofer Institute of Occupational Medicine (NIOM), National University of Singapore (NUS), Yong Loo Lin School of Medicine [Singapore], The Chinese University of Hong Kong [Hong Kong], Manisa Celal Bayar University, Universidad Nacional de Villa María, Universidad Católica de Córdoba, Beijing Tongren Hospital, Herrada, Anthony, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, and UCL - (MGD) Service de pneumologie

Subjects
Pulmonary and Respiratory Medicine, precision medicine, education, Immunology, Review, Settore MED/10 - Malattie Dell'Apparato Respiratorio, immune system diseases, HDE ALER, allergic rhinitis, asthma, immunotherapy, Medicine and Health Sciences, Immunology and Allergy, [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, ComputingMilieux_MISCELLANEOUS, Rhinitis, RC581-607, respiratory tract diseases, 3121 General medicine, internal medicine and other clinical medicine, Immunologic diseases. Allergy, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, [SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology, allergic rhinitis, asthma, immunotherapy, precision medicine
Abstract

Funding Information: BSreports personal fees from Allergopharma, during the conduct of the study; grants from National Health Programm, grant, personal fees from Polpharma, ASTRA, personal fees from Mylan, Adamed, patient ombudsman, national Centre for Research and Development, Polish Allergology Society. Funding Information: NGP reports personal fees from Novartis, Nutricia, HAL, MENARINI/FAES FARMA, SANOFI, MYLAN/MEDA, BIOMAY, AstraZeneca, GSK, MSD, ASIT BIOTECH, Boehringer Ingelheim, grants from Gerolymatos International SA, Capricare. Funding Information: CA reports grants from Allergopharma, grants from Idorsia, Swiss National Science Foundation, Christine Kühne‐Center for Allergy Research and Education, European Commission's Horison's 2020 Framework Programme, Cure, Novartis Research Institutes, Astra Zeneca, scibase, advisory role in Sanofi/Regeneron, grants from Glakso Smith‐Kline, advisory role in scibase. Funding Information: MJTreports grants from European Commission, SEAIC, ISCIII, personal fees from Diater laboratory, Leti laboratory, Aimmune Therapeutics. Funding Information: LK reports grants and personal fees from Allergopharma, MEDA/Mylan, LETI Pharma, Sanofi, grants from Stallergenes, Quintiles, ASIT biotech, grants from ALK Abelló, Lofarma, AstraZeneca, GSK, Inmunotk, personal fees from Allergy Therapeut., HAL Allergie, Cassella med; and Membership: AeDA, DGHNO, Deutsche Akademie für Allergologie und klinische Immunologie, HNO‐BV, GPA, EAACI. Funding Information: DPreports grants and personal fees from GlaxoSmithKline, personal fees from Menarini, Pliva, Belupo, AbbVie, Novartis, MSD, Chiesi, Revenio, personal fees and non‐financial support from Boehringer Ingelheim, non‐financial support from Philips. Funding Information: OP reports grants and personal fees from ALK‐Abelló, Allergopharma, Stallergenes Greer, HAL Allergy Holding B.V./HAL Allergie GmbH, Bencard Allergie GmbH/Allergy Therapeutics, Lofarma, ASIT Biotech Tools S.A., Laboratorios LETI/LETI Pharma, Anergis S.A., Glaxo Smith Kline, grants from Biomay, Circassia, Pohl‐Boskamp, Inmunotek S.L., personal fees from MEDA Pharma/MYLAN, Mobile Chamber Experts (a GA2LEN Partner), Indoor Biotechnologies, Astellas Pharma Global, EUFOREA, ROXALL Medizin, Novartis, Sanofi‐Aventis and Sanofi‐Genzyme, Med Update Europe GmbH, streamedup! GmbH, John Wiley and Sons, AS. Copyright: Copyright 2021 Elsevier B.V., All rights reserved. publishersversion published

Published
2021

190. Proposal of 0.5 mg of protein/100 g of processed food as threshold for voluntary declaration of food allergen traces in processed food—A first step in an initiative to better inform patients and avoid fatal allergic reactions: A GA²LEN position paper

Author

Zuberbier, Torsten, primary, Dörr, Tamara, additional, Aberer, Werner, additional, Alvaro, Montserrat, additional, Angier, Elizabeth, additional, Arasi, Stefania, additional, Arshad, Hasan, additional, Ballmer‐Weber, Barbara, additional, Bartra, Joan, additional, Beck, Lisa, additional, Bégin, Philippe, additional, Bindslev‐Jensen, Carsten, additional, Bislimovska, Jovanka, additional, Bousquet, Jean, additional, Brockow, Knut, additional, Bush, Andrew, additional, Cianferoni, Antonella, additional, Cork, Michael J., additional, Custovic, Adnan, additional, Darsow, Ulf, additional, Jong, Nicolette, additional, Deleanu, Diana, additional, Del Giacco, Stefano, additional, Deschildre, Antoine, additional, Dunn Galvin, Audrey, additional, Ebisawa, Motohiro, additional, Fernández‐Rivas, Montserrat, additional, Ferrer, Marta, additional, Fiocchi, Alessandro, additional, Gerth van Wijk, Roy, additional, Gotua, Maia, additional, Grimshaw, Kate, additional, Grünhagen, Josefine, additional, Heffler, Enrico, additional, Hide, Michihiro, additional, Hoffmann‐Sommergruber, Karin, additional, Incorvaia, Cristoforo, additional, Janson, Christer, additional, Malte John, Swen, additional, Jones, Carla, additional, Jutel, Marek, additional, Katoh, Norito, additional, Kendziora, Benjamin, additional, Kinaciyan, Tamar, additional, Knol, Edward, additional, Kurbacheva, Oksana, additional, Lau, Susanne, additional, Loh, Richard, additional, Lombardi, Carlo, additional, Mäkelä, Mika, additional, Marchisotto, Mary Jane, additional, Makris, Michael, additional, Maurer, Marcus, additional, Meyer, Rosan, additional, Mijakoski, Dragan, additional, Minov, Jordan, additional, Mullol, Joaquim, additional, Nilsson, Caroline, additional, Nowak–Wegrzyn, Anna, additional, Nwaru, Bright I., additional, Odemyr, Mikela, additional, Pajno, Giovanni Battista, additional, Paudel, Sushil, additional, Papadopoulos, Nikolaos G., additional, Renz, Harald, additional, Ricci, Giampaolo, additional, Ring, Johannes, additional, Rogala, Barbara, additional, Sampson, Hugh, additional, Senna, Gianenrico, additional, Sitkauskiene, Brigita, additional, Smith, Peter Kenneth, additional, Stevanovic, Katarina, additional, Stoleski, Sasho, additional, Szajewska, Hania, additional, Tanaka, Akio, additional, Todo‐Bom, Ana, additional, Topal, Fatih Alexander, additional, Valovirta, Erkka, additional, Van Ree, Ronald, additional, Venter, Carina, additional, Wöhrl, Stefan, additional, Wong, Gary W.K., additional, Zhao, Zuotao, additional, and Worm, Margitta, additional

Published
2021
Full Text
View/download PDF

192. Defining a Severe Asthma Super-Responder: Findings from a Delphi Process

Author

Upham, John W., primary, Le Lievre, Chantal, additional, Jackson, David J., additional, Masoli, Matthew, additional, Wechsler, Michael E., additional, Price, David B., additional, Mansur, Adel, additional, Detoraki, Aikaterini, additional, Altraja, Alan, additional, James, Alan, additional, Nanzer-Kelly, Alexandra, additional, Côté, Andréanne, additional, Menzies-Gow, Andrew, additional, Papaioannou, Andriana, additional, Cheffins, Anne-Maree, additional, Bourdin, Arnaud, additional, Mahboub, Bassam, additional, Lipworth, Brian, additional, Celis-Preciado, Carlos Andrés, additional, Torres-Duque, Carlos, additional, Bucca, Caterina, additional, Porsbjerg, Celeste, additional, Ulrik, Charlotte, additional, Corrigan, Chris, additional, Taube, Christian, additional, Farah, Claude, additional, Katelaris, Constance, additional, Langton, David, additional, Ryan, Dermot, additional, Larenas-Linnemann, Désirée, additional, Zervas, Eleftherios, additional, Heffler, Enrico, additional, Hoyte, Flavia, additional, Puggioni, Francesca, additional, Christoff, George, additional, Canonica, Giorgio Walter, additional, Carpagnano, Giovanna Elisiana, additional, Guida, Giuseppe, additional, Katsoulotos, Gregory, additional, Brusselle, Guy, additional, Rupani, Hitashi, additional, Jersmann, Hubertus, additional, Clifton, Ian, additional, Dhariwal, Jaideep, additional, Fingleton, James, additional, Duke, Jane, additional, Rimmer, Janet, additional, Douglass, Jo, additional, Fonseca, João, additional, van Boven, Job, additional, Corless, John, additional, Harrington, John, additional, Maspero, Jorge, additional, Miguel, José Luis, additional, Pipatvech, Kanok, additional, Kenny, Karrinda, additional, Chapman, Kenneth, additional, Kostikas, Konstantinos, additional, Lehtimäki, Lauri, additional, Chung, Li Ping, additional, Heaney, Liam, additional, Hang, Liang-Wen, additional, Boulet, Louis-Philippe, additional, Perez-de-Llano, Luis, additional, Ricciardi, Luisa, additional, Idrees, Majdy, additional, Milanese, Manlio, additional, Conte, Maria Elisabetta, additional, Costantino, Maria Teresa, additional, Siyue, Mariko Koh, additional, Fitzgerald, Mark, additional, Hew, Mark, additional, Peters, Matthew, additional, Tsai, Ming-Ju, additional, Patel, Mitesh, additional, Khan, Mohammad Hashim, additional, Sadatsafavi, Mohsen, additional, Al-Ahmad, Mona, additional, Yacoub, Mona-Rita, additional, De Gennaro, Mónica, additional, Radhakrishna, Naghmeh, additional, Hanania, Nicola Alexander, additional, Papadopoulos, Nikolaos, additional, Lugogo, Njira, additional, Linaker, Norma, additional, Crimi, Nunzio, additional, Dennison, Paddy, additional, Nair, Parameswaran, additional, Mitchell, Patrick David, additional, O’Byrne, Paul, additional, Pfeffer, Paul, additional, Kauppi, Paula, additional, Hughes, Pauline, additional, Middleton, Peter, additional, Wark, Peter, additional, Bardin, Philip, additional, Fu, Pin-Kuei, additional, Akuthota, Praveen, additional, Chaudhuri, Rekha, additional, Campos, Ricardo, additional, Al-Lehebi, Riyard, additional, Parente, Roberta, additional, Francisco, Rovira, additional, Wenzel, Sally, additional, Pierachille, Santus, additional, Pawar, Shrikant, additional, Loukides, Stelios, additional, Fowler, Stephen, additional, Mackenzie, Tara, additional, Brown, Thomas, additional, Lee Tan, Tze, additional, Björnsdóttir, Unnur, additional, McDonald, Vanessa, additional, Lawriwskyj, Veronica, additional, Backer, Vibeke, additional, Vasileva, Violina, additional, Chien, Ying-Chun, additional, and Harrington, Zinta, additional

Published
2021
Full Text
View/download PDF

193. Severe asthma: One disease and multiple definitions

Author

Bagnasco, Diego, primary, Paggiaro, Pierluigi, additional, Latorre, Manuela, additional, Folli, Chiara, additional, Testino, Elisa, additional, Bassi, Arianna, additional, Milanese, Manlio, additional, Heffler, Enrico, additional, Manfredi, Andrea, additional, Riccio, Anna Maria, additional, De Ferrari, Laura, additional, Blasi, Francesco, additional, Canevari, Rikki Frank, additional, Canonica, Giorgio Walter, additional, Passalacqua, Giovanni, additional, Guarnieri, Gabriella, additional, Patella, Vincenzo, additional, Maria Pia, Foschino Barbaro, additional, Carpagnano, Giovanna Elisiana, additional, Colle, Anna del, additional, Scioscia, Giulia, additional, Gerolamo, Pelaia, additional, Puggioni, Francesca, additional, Racca, Francesca, additional, Favero, Elisabetta, additional, Iannacone, Sandra, additional, Savi, Eleonora, additional, Montagni, Marcello, additional, Camiciottoli, Gianna, additional, Allegrini, Chiara, additional, Lombardi, Carlo, additional, Spadaro, Giuseppe, additional, Detoraki, Caterina, additional, Menzella, Francesco, additional, Galeone, Carla, additional, Ruggiero, Patrizia, additional, Yacoub, Monna Rita, additional, Berti, Alvise, additional, Scichilone, Nicola, additional, Durante, Carmen, additional, Costantino, Maria Teresa, additional, Roncallo, Chiara, additional, Braschi, Mariachiara, additional, D’Adda, Alice, additional, Ridolo, Erminia, additional, Triggiani, Massimo, additional, Parente, Roberta, additional, Maria, D’Amato, additional, Verrillo, Maria Vittoria, additional, Rolla, Giovanni, additional, Brussino, Luisa, additional, Frazzetto, Agata Valentina, additional, Cristina, Zappa Maria, additional, Lilli, Marianna, additional, Crimi, Nunzio, additional, Bonavia, Marco, additional, Corsico, Angelo Guido, additional, Grosso, Amelia, additional, Del Giacco, Stefano, additional, Deidda, Margherita, additional, Ricciardi, Luisa, additional, Isola, Stefania, additional, Cicero, Francesca, additional, Amato, Giuliana, additional, Vita, Federica, additional, Spanevello, Antonio, additional, Pignatti, Patrizia, additional, Cherubino, Francesca, additional, Visca, Dina, additional, Massimo Ricciardolo, Fabio Luigi, additional, Anna Carriero, Vitina Maria, additional, Bertolini, Francesca, additional, Santus, Pierachille, additional, Barlassina, Roberta, additional, Airoldi, Andrea, additional, Guida, Giuseppe, additional, Eleonora, Nucera, additional, Aruanno, Arianna, additional, Rizzi, Angela, additional, Caruso, Cristiano, additional, Colantuono, Stefania, additional, Senna, Gianenrico, additional, Caminati, Marco, additional, Arcolaci, Alessandra, additional, Vianello, Andrea, additional, Bianchi, Fulvia Chieco, additional, Marchi, Maria Rita, additional, Centanni, Stefano, additional, Luraschi, Simone, additional, Ruggeri, Silvia, additional, Rinaldo, Rocco, additional, Parazzini, Elena, additional, Calabrese, Cecilia, additional, Flora, Martina, additional, Cosmi, Lorenzo, additional, Di Pietro, Linda, additional, Maggi, Enrico, additional, Pini, Laura, additional, Macchia, Luigi, additional, Di Bona, Danilo, additional, Richeldi, Luca, additional, Condoluci, Carola, additional, Fuso, Leonello, additional, Bonini, Matteo, additional, Farsi, Alessandro, additional, Carli, Giulia, additional, Montuschi, Paolo, additional, Santini, Giuseppe, additional, Conte, Maria Elisabetta, additional, Turchet, Elisa, additional, Barbetta, Carlo, additional, Mazza, Francesco, additional, D’Alo, Simona, additional, Pucci, Stefano, additional, Caiaffa, Maria Filomena, additional, Minenna, Elena, additional, D'Elia, Luciana, additional, Pasculli, Carlo, additional, Viviano, Vittorio, additional, Tarsia, Paolo, additional, Rolo, Joyce, additional, Di Proietto, Mariacarmela, additional, and Lo Cicero, Salvatore, additional

Published
2021
Full Text
View/download PDF

197. The European Curriculum for Additional Qualification Allergology A Position Paper by Medical Association of German Allergologists (AeDA), German Society for Allergology and Clinical Immunology (DGAKI) and Society for Pediatric Allergology and Environmental Medicine (GPA) in cooperation with European Academy for Allergology and Clinical Immunology (EAACI) and Allergology Section of European Union of Medical Specialists (UEMS)

Author

Muelleneisen, Norbert, Klimek, Ludger, Worm, Margitta, Merk, Hans, Rabe, Uta, Biedermann, Tilo, Jung, Kirsten, Schlenter, Wolfgang, Ring, Johannes, Chaker, Adam, Wehrmann, Wolfgang, Becker, Sven, Bergmann, Karl-Christian A., Nemat, Katja, Czech, Wolfgang, Wrede, Holger, Brehler, Randolf, Fuchs, Thomas, Matricardi, Paolo, Hamelmann, Eckard, Jakob, Thilo, Werfel, Thomas, Wagenmann, Martin, Taube, Christian, Gerstlauer, Michael, Vogelberg, Christian, Van Wijk, Roy Gerth, Eguiluz-Gracia, Ibon, Gayraud, Jacques, Gutermuth, Jan, Heffler, Enrico, Popov, Todor A., Schmid-Grendelmeier, Peter, Tomazic, Peter, V, Tsilochristou, Olympia, Del Giacco, Stefano, Zuberbier, Torsten, Jutel, Marek, Artificial Intelligence supported Modelling in clinical Sciences, Gerontology, Skin function and permeability, and Dermatology

Subjects
The European Curriculum for Additional Qualification Allergolog, Dermatology
Published
2021

199. Allergen immunotherapy: The growing role of observational and randomized trial “Real‐World Evidence”

Author

Paoletti, Giovanni, primary, Di Bona, Danilo, additional, Chu, Derek K., additional, Firinu, Davide, additional, Heffler, Enrico, additional, Agache, Ioana, additional, Jutel, Marek, additional, Klimek, Ludger, additional, Pfaar, Oliver, additional, Mösges, Ralph, additional, DunnGalvin, Audrey, additional, Genuneit, Jon, additional, Hoffmann, Hans Jürgen, additional, and Canonica, Giorgio Walter, additional

Published
2021
Full Text
View/download PDF

200. COVID‐19 pandemic and allergen immunotherapy—an EAACI survey

Author

Pfaar, Oliver, primary, Agache, Ioana, additional, Bonini, Matteo, additional, Brough, Helen Annaruth, additional, Chivato, Tomás, additional, Del Giacco, Stefano R., additional, Gawlik, Radoslaw, additional, Gelincik, Aslı, additional, Hoffmann‐Sommergruber, Karin, additional, Jutel, Marek, additional, Klimek, Ludger, additional, Knol, Edward F., additional, Lauerma, Antti, additional, Ollert, Markus, additional, O’Mahony, Liam, additional, Mortz, Charlotte G., additional, Palomares, Oscar, additional, Riggioni, Carmen, additional, Schwarze, Jürgen, additional, Skypala, Isabel, additional, Torres, María José, additional, Untersmayr, Eva, additional, Walusiak‐Skorupa, Jolanta, additional, Chaker, Adam, additional, Giovannini, Mattia, additional, Heffler, Enrico, additional, Jensen‐Jarolim, Erika, additional, Quecchia, Cristina, additional, Sandoval‐Ruballos, Mónica, additional, Sahiner, Umit, additional, Tomić Spirić, Vesna, additional, and Alvaro‐Lozano, Montserrat, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results