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731 results on '"Heath, Alicia"'

151. A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC

Author

Papadimitriou, Nikos, Bouras, Emmanouil, van den Brandt, Piet A, Muller, David C, Papadopoulou, Areti, Heath, Alicia K, Critselis, Elena, Gunter, Marc J, Vineis, Paolo, Ferrari, Pietro, Weiderpass, Elisabete, Boeing, Heiner, Bastide, Nadia, Merritt, Melissa A, Lopez, David S, Bergmann, Manuela M, Perez-Cornago, Aurora, Schulze, Matthias, Skeie, Guri, Srour, Bernard, Eriksen, Anne Kirstine, Boden, Stina, Johansson, Ingegerd, Nøst, Therese Haugdahl, Lukic, Marco, Ricceri, Fulvio, Ericson, Ulrika, Huerta, José María, Dahm, Christina C, Agnoli, Claudia, Amiano, Pilar Exezarreta, Tjønneland, Anne, Gurrea, Aurelio Barricarte, Bueno-de-Mesquita, Bas, Ardanaz, Eva, Berntsson, Jonna, Sánchez, Maria-Jose, Tumino, Rosario, Panico, Salvatore, Katzke, Verena, Jakszyn, Paula, Masala, Giovanna, Derksen, Jeroen W G, Quirós, J Ramón, Severi, Gianluca, Cross, Amanda J, Riboli, Ellio, Tzoulaki, Ioanna, Tsilidis, Konstantinos K, Papadimitriou, Nikos, Bouras, Emmanouil, van den Brandt, Piet A, Muller, David C, Papadopoulou, Areti, Heath, Alicia K, Critselis, Elena, Gunter, Marc J, Vineis, Paolo, Ferrari, Pietro, Weiderpass, Elisabete, Boeing, Heiner, Bastide, Nadia, Merritt, Melissa A, Lopez, David S, Bergmann, Manuela M, Perez-Cornago, Aurora, Schulze, Matthias, Skeie, Guri, Srour, Bernard, Eriksen, Anne Kirstine, Boden, Stina, Johansson, Ingegerd, Nøst, Therese Haugdahl, Lukic, Marco, Ricceri, Fulvio, Ericson, Ulrika, Huerta, José María, Dahm, Christina C, Agnoli, Claudia, Amiano, Pilar Exezarreta, Tjønneland, Anne, Gurrea, Aurelio Barricarte, Bueno-de-Mesquita, Bas, Ardanaz, Eva, Berntsson, Jonna, Sánchez, Maria-Jose, Tumino, Rosario, Panico, Salvatore, Katzke, Verena, Jakszyn, Paula, Masala, Giovanna, Derksen, Jeroen W G, Quirós, J Ramón, Severi, Gianluca, Cross, Amanda J, Riboli, Ellio, Tzoulaki, Ioanna, and Tsilidis, Konstantinos K

Abstract

BACKGROUND & AIMS: Evidence regarding the association of dietary exposures with colorectal cancer (CRC) risk is not consistent with a few exceptions. Therefore, we conducted a diet-wide association study (DWAS) in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the associations between several dietary exposures with CRC risk.METHODS: The association of 92 food and nutrient intakes with CRC risk was assessed in 386,792 participants, 5069 of whom developed incident CRC. Correction for multiple comparisons was performed using the false discovery rate, and emerging associations were examined in the Netherlands Cohort Study (NLCS). Multiplicative gene-nutrient interactions were also tested in EPIC based on known CRC-associated loci.RESULTS: In EPIC, alcohol, liquor/spirits, wine, beer/cider, soft drinks, and pork were positively associated with CRC, whereas milk, cheese, calcium, phosphorus, magnesium, potassium, riboflavin, vitamin B6, beta carotene, fruit, fiber, nonwhite bread, banana, and total protein intakes were inversely associated. Of these 20 associations, 13 were replicated in the NLCS, for which a meta-analysis was performed, namely alcohol (summary hazard ratio [HR] per 1-SD increment in intake: 1.07; 95% confidence interval [CI], 1.04-1.09), liquor/spirits (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02-1.06), wine (HR per 1-SD increment in intake, 1.04; 95% CI, 1.02-1.07), beer/cider (HR per 1-SD increment in intake, 1.06; 95% CI, 1.04-1.08), milk (HR per 1-SD increment in intake, 0.95; 95% CI, 0.93-0.98), cheese (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94-0.99), calcium (HR per 1-SD increment in intake, 0.93; 95% CI, 0.90-0.95), phosphorus (HR per 1-SD increment in intake, 0.92; 95% CI, 0.90-0.95), magnesium (HR per 1-SD increment in intake, 0.95; 95% CI, 0.92-0.98), potassium (HR per 1-SD increment in intake, 0.96; 95% CI, 0.94-0.99), riboflavin (HR per 1-SD increment in intake, 0.94

Published
2022

152. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., Viallon, Vivian, Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian

Abstract

Background: Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations. Methods: We analysed targeted metabolomics data available for 5828 matched case-control pairs from cancer-specific case-control studies on breast, colorectal, endometrial, gallbladder, kidney, localized and advanced prostate cancer, and hepatocellular carcinoma nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. From pre-diagnostic blood levels of an initial set of 117 metabolites, 33 cluster representatives of strongly correlated metabolites and 17 single metabolites were derived by hierarchical clustering. The mutually adjusted associations of the resulting 50 metabolites with cancer risk were examined in penalized conditional logistic regression models adjusted for body mass index, using the data-shared lasso penalty. Results: Out of the 50 studied metabolites, (i) six were inversely associated with the risk of most cancer types: glutamine, butyrylcarnitine, lysophosphatidylcholine a C18:2, and three clusters of phosphatidylcholines (PCs); (ii) three were positively associated with most cancer types: proline, decanoylcarnitine, and one cluster of PCs; and (iii) 10 were specifically associated with particular cancer types, including histidine that was inversely associated with colorectal cancer risk and one cluster of sphingomyelins that was inversely associated with risk of hepatocellular carcinoma and positively with endometrial cancer risk. Conclusions: These results could provide novel insights for the identification of pathways for cancer development, in particular those shared across different cancer types.

Published
2022
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153. Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer

Author

Mukama, Trasias, Fortner, Renée Turzanski, Katzke, Verena, Hynes, Lucas Cory, Petrera, Agnese, Hauck, Stefanie M., Johnson, Theron, Schulze, Matthias, Schiborn, Catarina, Rostgaard-Hansen, Agnetha Linn, Tjønneland, Anne, Overvad, Kim, Pérez, María José Sánchez, Crous-Bou, Marta, Chirlaque, María-Dolores, Amiano, Pilar, Ardanaz, Eva, Watts, Eleanor L., Travis, Ruth C., Sacerdote, Carlotta, Grioni, Sara, Masala, Giovanna, Signoriello, Simona, Tumino, Rosario, Gram, Inger T., Sandanger, Torkjel M., Sartor, Hanna, Lundin, Eva, Idahl, Annika, Heath, Alicia K., Dossus, Laure, Weiderpass, Elisabete, Kaaks, Rudolf, Mukama, Trasias, Fortner, Renée Turzanski, Katzke, Verena, Hynes, Lucas Cory, Petrera, Agnese, Hauck, Stefanie M., Johnson, Theron, Schulze, Matthias, Schiborn, Catarina, Rostgaard-Hansen, Agnetha Linn, Tjønneland, Anne, Overvad, Kim, Pérez, María José Sánchez, Crous-Bou, Marta, Chirlaque, María-Dolores, Amiano, Pilar, Ardanaz, Eva, Watts, Eleanor L., Travis, Ruth C., Sacerdote, Carlotta, Grioni, Sara, Masala, Giovanna, Signoriello, Simona, Tumino, Rosario, Gram, Inger T., Sandanger, Torkjel M., Sartor, Hanna, Lundin, Eva, Idahl, Annika, Heath, Alicia K., Dossus, Laure, Weiderpass, Elisabete, and Kaaks, Rudolf

Abstract

Background: CA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There is a need to identify novel biomarkers, which individually or in combination with CA125 can achieve adequate sensitivity and specificity for the detection of earlier-stage ovarian cancer. Methods: In the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, we measured serum levels of 92 preselected proteins for 91 women who had blood sampled ≤18 months prior to ovarian cancer diagnosis, and 182 matched controls. We evaluated the discriminatory performance of the proteins as potential early diagnostic biomarkers of ovarian cancer. Results: Nine of the 92 markers; CA125, HE4, FOLR1, KLK11, WISP1, MDK, CXCL13, MSLN and ADAM8 showed an area under the ROC curve (AUC) of ≥0.70 for discriminating between women diagnosed with ovarian cancer and women who remained cancer-free. All, except ADAM8, had shown at least equal discrimination in previous case-control comparisons. The discrimination of the biomarkers, however, was low for the lag-time of >9–18 months and paired combinations of CA125 with any of the 8 markers did not improve discrimination compared to CA125 alone. Conclusion: Using pre-diagnostic serum samples, this study identified markers with good discrimination for the lag-time of 0–9 months. However, the discrimination was low in blood samples collected more than 9 months prior to diagnosis, and none of the markers showed major improvement in discrimination when added to CA125.

Published
2022
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154. Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

Author

MS MDL 1, Planetary Health & Exposoom, Heath, Alicia K, Muller, David C, van den Brandt, Piet A, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Boeing, Heiner, Ferrari, Pietro, Merritt, Melissa A, Rostgaard-Hansen, Agnetha L, Tjønneland, Anne, Overvad, Kim, Katzke, Verena, Srour, Bernard, Masala, Giovanna, Sacerdote, Carlotta, Ricceri, Fulvio, Pasanisi, Fabrizio, Bueno-de-Mesquita, Bas, Downward, George S, Skeie, Guri, Sandanger, Torkjel M, Crous-Bou, Marta, Rodríguez-Barranco, Miguel, Amiano, Pilar, Huerta, José María, Ardanaz, Eva, Drake, Isabel, Johansson, Mikael, Johansson, Ingegerd, Key, Tim, Papadimitriou, Nikos, Riboli, Elio, Tzoulaki, Ioanna, Tsilidis, Konstantinos K, MS MDL 1, Planetary Health & Exposoom, Heath, Alicia K, Muller, David C, van den Brandt, Piet A, Critselis, Elena, Gunter, Marc, Vineis, Paolo, Weiderpass, Elisabete, Boeing, Heiner, Ferrari, Pietro, Merritt, Melissa A, Rostgaard-Hansen, Agnetha L, Tjønneland, Anne, Overvad, Kim, Katzke, Verena, Srour, Bernard, Masala, Giovanna, Sacerdote, Carlotta, Ricceri, Fulvio, Pasanisi, Fabrizio, Bueno-de-Mesquita, Bas, Downward, George S, Skeie, Guri, Sandanger, Torkjel M, Crous-Bou, Marta, Rodríguez-Barranco, Miguel, Amiano, Pilar, Huerta, José María, Ardanaz, Eva, Drake, Isabel, Johansson, Mikael, Johansson, Ingegerd, Key, Tim, Papadimitriou, Nikos, Riboli, Elio, Tzoulaki, Ioanna, and Tsilidis, Konstantinos K

Published
2022

155. Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort

Author

Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Gil-Lespinard, Mercedes, Castañeda, Jazmín, Almanza-Aguilera, Enrique, Gómez, Jesús Humberto, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Katzke, Verena, Schulze, Matthias B, Masala, Giovanna, Agnoli, Claudia, Santucci de Magistris, Maria, Tumino, Rosario, Sacerdote, Carlotta, Skeie, Guri, Lasheras, Cristina, Molina-Montes, Esther, Huerta, José María, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, da Silva, Marisa, Johansson, Ingegerd, Hultdin, Johan, May, Anne M, Forouhi, Nita G, Heath, Alicia K, Freisling, Heinz, Weiderpass, Elisabete, Scalbert, Augustin, Zamora-Ros, Raul, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Gil-Lespinard, Mercedes, Castañeda, Jazmín, Almanza-Aguilera, Enrique, Gómez, Jesús Humberto, Tjønneland, Anne, Kyrø, Cecilie, Overvad, Kim, Katzke, Verena, Schulze, Matthias B, Masala, Giovanna, Agnoli, Claudia, Santucci de Magistris, Maria, Tumino, Rosario, Sacerdote, Carlotta, Skeie, Guri, Lasheras, Cristina, Molina-Montes, Esther, Huerta, José María, Barricarte, Aurelio, Amiano, Pilar, Sonestedt, Emily, da Silva, Marisa, Johansson, Ingegerd, Hultdin, Johan, May, Anne M, Forouhi, Nita G, Heath, Alicia K, Freisling, Heinz, Weiderpass, Elisabete, Scalbert, Augustin, and Zamora-Ros, Raul

Published
2022

156. Cruciferous Vegetable Intake and Bulky DNA Damage within Non-Smokers and Former Smokers in the Gen-Air Study (EPIC Cohort)

Author

Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Peluso, Marco, Munnia, Armelle, Russo, Valentina, Galli, Andrea, Pala, Valeria, Schouw, Yvonne T van der, Schulze, Matthias B, Weiderpass, Elisabete, Tumino, Rosario, Saieva, Calogero, Exezarreta Pilar, Amiano, Aune, Dagfinn, Heath, Alicia K, Aglago, Elom, Agudo, Antonio, Panico, Salvatore, Petersen, Kristina Elin Nielsen, Tjønneland, Anne, Cirera, Lluís, Rodriguez-Barranco, Miguel, Katzke, Verena, Kaaks, Rudolf, Ricceri, Fulvio, Milani, Lorenzo, Vineis, Paolo, Sacerdote, Carlotta, Cardiovasculaire Epi Team 1, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Peluso, Marco, Munnia, Armelle, Russo, Valentina, Galli, Andrea, Pala, Valeria, Schouw, Yvonne T van der, Schulze, Matthias B, Weiderpass, Elisabete, Tumino, Rosario, Saieva, Calogero, Exezarreta Pilar, Amiano, Aune, Dagfinn, Heath, Alicia K, Aglago, Elom, Agudo, Antonio, Panico, Salvatore, Petersen, Kristina Elin Nielsen, Tjønneland, Anne, Cirera, Lluís, Rodriguez-Barranco, Miguel, Katzke, Verena, Kaaks, Rudolf, Ricceri, Fulvio, Milani, Lorenzo, Vineis, Paolo, and Sacerdote, Carlotta

Published
2022

157. Meat Intake Is Associated with a Higher Risk of Ulcerative Colitis in a Large European Prospective Cohort Studyø

Author

MS MDL 1, Infection & Immunity, Dong, Catherine, Chan, Simon S M, Jantchou, Prevost, Racine, Antoine, Oldenburg, Bas, Weiderpass, Elisabete, Heath, Alicia K, Tong, Tammy Y N, Tjønneland, Anne, Kyrø, Cecilie, de Mesquita, Bas Bueno, Kaaks, Rudolf, Katzke, Verena A, Bergman, Manuela M, Boeing, Heiner, Palli, Domenico, Masala, Giovanna, Tumino, Rosario, Sacerdote, Carlotta, Colorado-Yohar, Sandra M, Sánchez, Maria-Jose, Grip, Olof, Lindgren, Stefan, Luben, Robert, Huybrechts, Inge, Gunter, Marc J, Mahamat-Saleh, Yahya, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, MS MDL 1, Infection & Immunity, Dong, Catherine, Chan, Simon S M, Jantchou, Prevost, Racine, Antoine, Oldenburg, Bas, Weiderpass, Elisabete, Heath, Alicia K, Tong, Tammy Y N, Tjønneland, Anne, Kyrø, Cecilie, de Mesquita, Bas Bueno, Kaaks, Rudolf, Katzke, Verena A, Bergman, Manuela M, Boeing, Heiner, Palli, Domenico, Masala, Giovanna, Tumino, Rosario, Sacerdote, Carlotta, Colorado-Yohar, Sandra M, Sánchez, Maria-Jose, Grip, Olof, Lindgren, Stefan, Luben, Robert, Huybrechts, Inge, Gunter, Marc J, Mahamat-Saleh, Yahya, Boutron-Ruault, Marie-Christine, and Carbonnel, Franck

Published
2022

158. Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study

Author

Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 1, Fortuin-de Smidt, Melony C, Sewe, Maquins Odhiambo, Lasalle, Camille, Weiderpass, Elisabete, Andersson, Jonas, Huerta, José María, Ekelund, Ulf, Aleksandrova, Krasimira, Tong, Tammy Yn, Dahm, Christina C, Tjønneland, Anne, Kyrø, Cecilie, Steindorf, Karen, Schulze, Matthias B, Katzke, Verena, Sacerdote, Carlotta, Agnoli, Claudia, Masala, Giovanna, Tumino, Rosario, Panico, Salvatore, Boer, Jolanda Ma, Onland-Moret, N Charlotte, Wendel-Vos, Gc Wanda, van der Schouw, Yvonne T, Borch, Kristin Benjaminsen, Agudo, Antonio, Petrova, Dafina, Chirlaque, María-Dolores, Conchi, Moreno-Iribas, Amiano, Pilar, Melander, Olle, Heath, Alicia K, Aune, Dagfinn, Forouhi, Nita G, Langenberg, Claudia, Brage, Soren, Riboli, Elio, Wareham, Nicholas J, Danesh, John, Butterworth, Adam S, Wennberg, Patrik, Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 1, Fortuin-de Smidt, Melony C, Sewe, Maquins Odhiambo, Lasalle, Camille, Weiderpass, Elisabete, Andersson, Jonas, Huerta, José María, Ekelund, Ulf, Aleksandrova, Krasimira, Tong, Tammy Yn, Dahm, Christina C, Tjønneland, Anne, Kyrø, Cecilie, Steindorf, Karen, Schulze, Matthias B, Katzke, Verena, Sacerdote, Carlotta, Agnoli, Claudia, Masala, Giovanna, Tumino, Rosario, Panico, Salvatore, Boer, Jolanda Ma, Onland-Moret, N Charlotte, Wendel-Vos, Gc Wanda, van der Schouw, Yvonne T, Borch, Kristin Benjaminsen, Agudo, Antonio, Petrova, Dafina, Chirlaque, María-Dolores, Conchi, Moreno-Iribas, Amiano, Pilar, Melander, Olle, Heath, Alicia K, Aune, Dagfinn, Forouhi, Nita G, Langenberg, Claudia, Brage, Soren, Riboli, Elio, Wareham, Nicholas J, Danesh, John, Butterworth, Adam S, and Wennberg, Patrik

Published
2022

159. The relationship between blood pressure and risk of renal cell carcinoma

Author

Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Alcala, Karine, Mariosa, Daniela, Smith-Byrne, Karl, Nesheli, Dariush Nasrollahzadeh, Carreras-Torres, Robert, Aicua, Eva Ardanaz, Bondonno, Nicola P., Bonet, Catalina, Brunstrom, Mattias, Bueno-de-Mesquita, Bas, Chirlaque, Maria-Dolores, Christakoudi, Sofia, Heath, Alicia K., Kaaks, Rudolf, Katzke, Verena, Krogh, Vittorio, Ljungberg, Borje, Martin, Richard M., May, Anne, Melander, Olle, Palli, Domenico, Rodriguez-Barranco, Miguel, Sacerdote, Carlotta, Stocks, Tanja, Tjonneland, Anne, Travis, Ruth C., Vermeulen, Roel, Chanock, Stephen, Purdue, Mark, Weiderpass, Elisabete, Muller, David, Brennan, Paul, Johansson, Mattias, Epi Kanker, Cancer, JC onderzoeksprogramma Kanker, Epidemiology & Health Economics, Alcala, Karine, Mariosa, Daniela, Smith-Byrne, Karl, Nesheli, Dariush Nasrollahzadeh, Carreras-Torres, Robert, Aicua, Eva Ardanaz, Bondonno, Nicola P., Bonet, Catalina, Brunstrom, Mattias, Bueno-de-Mesquita, Bas, Chirlaque, Maria-Dolores, Christakoudi, Sofia, Heath, Alicia K., Kaaks, Rudolf, Katzke, Verena, Krogh, Vittorio, Ljungberg, Borje, Martin, Richard M., May, Anne, Melander, Olle, Palli, Domenico, Rodriguez-Barranco, Miguel, Sacerdote, Carlotta, Stocks, Tanja, Tjonneland, Anne, Travis, Ruth C., Vermeulen, Roel, Chanock, Stephen, Purdue, Mark, Weiderpass, Elisabete, Muller, David, Brennan, Paul, and Johansson, Mattias

Published
2022

160. A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC

Author

MS MDL 1, Epi Kanker Team B, Cancer, Papadimitriou, Nikos, Bouras, Emmanouil, van den Brandt, Piet A, Muller, David C, Papadopoulou, Areti, Heath, Alicia K, Critselis, Elena, Gunter, Marc J, Vineis, Paolo, Ferrari, Pietro, Weiderpass, Elisabete, Boeing, Heiner, Bastide, Nadia, Merritt, Melissa A, Lopez, David S, Bergmann, Manuela M, Perez-Cornago, Aurora, Schulze, Matthias, Skeie, Guri, Srour, Bernard, Eriksen, Anne Kirstine, Boden, Stina, Johansson, Ingegerd, Nøst, Therese Haugdahl, Lukic, Marco, Ricceri, Fulvio, Ericson, Ulrika, Huerta, José María, Dahm, Christina C, Agnoli, Claudia, Amiano, Pilar Exezarreta, Tjønneland, Anne, Gurrea, Aurelio Barricarte, Bueno-de-Mesquita, Bas, Ardanaz, Eva, Berntsson, Jonna, Sánchez, Maria-Jose, Tumino, Rosario, Panico, Salvatore, Katzke, Verena, Jakszyn, Paula, Masala, Giovanna, Derksen, Jeroen W G, Quirós, J Ramón, Severi, Gianluca, Cross, Amanda J, Riboli, Ellio, Tzoulaki, Ioanna, Tsilidis, Konstantinos K, MS MDL 1, Epi Kanker Team B, Cancer, Papadimitriou, Nikos, Bouras, Emmanouil, van den Brandt, Piet A, Muller, David C, Papadopoulou, Areti, Heath, Alicia K, Critselis, Elena, Gunter, Marc J, Vineis, Paolo, Ferrari, Pietro, Weiderpass, Elisabete, Boeing, Heiner, Bastide, Nadia, Merritt, Melissa A, Lopez, David S, Bergmann, Manuela M, Perez-Cornago, Aurora, Schulze, Matthias, Skeie, Guri, Srour, Bernard, Eriksen, Anne Kirstine, Boden, Stina, Johansson, Ingegerd, Nøst, Therese Haugdahl, Lukic, Marco, Ricceri, Fulvio, Ericson, Ulrika, Huerta, José María, Dahm, Christina C, Agnoli, Claudia, Amiano, Pilar Exezarreta, Tjønneland, Anne, Gurrea, Aurelio Barricarte, Bueno-de-Mesquita, Bas, Ardanaz, Eva, Berntsson, Jonna, Sánchez, Maria-Jose, Tumino, Rosario, Panico, Salvatore, Katzke, Verena, Jakszyn, Paula, Masala, Giovanna, Derksen, Jeroen W G, Quirós, J Ramón, Severi, Gianluca, Cross, Amanda J, Riboli, Ellio, Tzoulaki, Ioanna, and Tsilidis, Konstantinos K

Published
2022

162. Body shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study.

Author

Sedlmeier, Anja M., Viallon, Vivian, Ferrari, Pietro, Peruchet-Noray, Laia, Fontvieille, Emma, Amadou, Amina, Seyed Khoei, Nazlisadat, Weber, Andrea, Baurecht, Hansjörg, Heath, Alicia K., Tsilidis, Kostas, Kaaks, Rudolf, Katzke, Verena, Inan-Eroglu, Elif, Schulze, Matthias B., Overvad, Kim, Bonet, Catalina, Ubago-Guisado, Esther, Chirlaque, María-Dolores, and Ardanaz, Eva

Abstract

Background: Classical anthropometric traits may fail to fully represent the relationship of weight, adiposity, and height with cancer risk. We investigated the associations of body shape phenotypes with the risk of overall and site-specific cancers.Methods: We derived four distinct body shape phenotypes from principal component (PC) analysis on height, weight, body mass index (BMI), waist (WC) and hip circumferences (HC), and waist-to-hip ratio (WHR). The study included 340,152 men and women from 9 European countries, aged mostly 35-65 years at recruitment (1990-2000) in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).Results: After a median follow-up of 15.3 years, 47,110 incident cancer cases were recorded. PC1 (overall adiposity) was positively associated with the risk of overall cancer, with a HR per 1 standard deviation (SD) increment equal to 1.07 (95% confidence interval 1.05 to 1.08). Positive associations were observed with 10 cancer types, with HRs (per 1 SD) ranging from 1.36 (1.30-1.42) for endometrial cancer to 1.08 (1.03-1.13) for rectal cancer. PC2 (tall stature with low WHR) was positively associated with the risk of overall cancer (1.03; 1.02-1.04) and five cancer types which were not associated with PC1. PC3 (tall stature with high WHR) was positively associated with the risk of overall cancer (1.04; 1.03-1.05) and 12 cancer types. PC4 (high BMI and weight with low WC and HC) was not associated with overall risk of cancer (1.00; 0.99-1.01).Conclusions: In this multi-national study, distinct body shape phenotypes were positively associated with the incidence of 17 different cancers and overall cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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163. Blood pressure, hypertension and the risk of atrial fibrillation: a systematic review and meta-analysis of cohort studies.

Author

Aune, Dagfinn, Mahamat-Saleh, Yahya, Kobeissi, Elsa, Feng, Tingting, Heath, Alicia K., and Janszky, Imre

Subjects
BLOOD pressure, DIASTOLIC blood pressure, SYSTOLIC blood pressure, ATRIAL fibrillation, HYPERTENSION, RANDOM effects model, COHORT analysis
Abstract

Elevated blood pressure and hypertension have been associated with increased risk of atrial fibrillation in a number of epidemiological studies, however, the strength of the association has differed between studies. We conducted a systematic review and meta-analysis of the association between blood pressure and hypertension and atrial fibrillation. PubMed and Embase databases were searched for studies of hypertension and blood pressure and atrial fibrillation up to June 6th 2022. Cohort studies reporting adjusted relative risk (RR) estimates and 95% confidence intervals (CIs) of atrial fibrillation associated with hypertension or blood pressure were included. A random effects model was used to estimate summary RRs. Sixty eight cohort studies were included in the meta-analysis. The summary RR was 1.50 (95% CI: 1.42–1.58, I2 = 98.1%, n = 56 studies) for people with hypertension compared to those without hypertension (1,080,611 cases, 30,539,230 participants), 1.18 (95% CI: 1.16–1.21, I2 = 65.9%, n = 37 studies) per 20 mmHg increase in systolic blood pressure (346,471 cases, 14,569,396 participants), and 1.07 (95% CI: 1.03–1.11, I2 = 91.5%, n = 22 studies) per 10 mmHg increase in diastolic blood pressure (332,867 cases, 14,354,980 participants). There was evidence of a nonlinear association between diastolic blood pressure and atrial fibrillation with a steeper increase in risk at lower levels of diastolic blood pressure, but for systolic blood pressure the association appeared to be linear. For both systolic and diastolic blood pressure, the risk increased even within the normal range of blood pressure and persons at the high end of systolic and diastolic blood pressure around 180/110 mmHg had a 1.8–2.3 fold higher risk of atrial fibrillation compared to those with a blood pressure of 90/60 mmHg. These results suggest that elevated blood pressure and hypertension increases the risk of atrial fibrillation and there is some increase in risk even within the normal range of systolic and diastolic blood pressure. [ABSTRACT FROM AUTHOR]

Published
2023
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164. Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study

Author

Mariosa, Daniela, primary, Smith-Byrne, Karl, additional, Richardson, Tom G, additional, Ferrari, Pietro, additional, Gunter, Marc J, additional, Papadimitriou, Nikos, additional, Murphy, Neil, additional, Christakoudi, Sofia, additional, Tsilidis, Konstantinos K, additional, Riboli, Elio, additional, Muller, David, additional, Purdue, Mark P, additional, Chanock, Stephen J, additional, Hung, Rayjean J, additional, Amos, Christopher I, additional, O’Mara, Tracy A, additional, Amiano, Pilar, additional, Pasanisi, Fabrizio, additional, Rodriguez-Barranco, Miguel, additional, Krogh, Vittorio, additional, Tjønneland, Anne, additional, Halkjær, Jytte, additional, Perez-Cornago, Aurora, additional, Chirlaque, María-Dolores, additional, Skeie, Guri, additional, Rylander, Charlotta, additional, Borch, Kristin Benjaminsen, additional, Aune, Dagfinn, additional, Heath, Alicia K, additional, Ward, Heather A, additional, Schulze, Matthias, additional, Bonet, Catalina, additional, Weiderpass, Elisabete, additional, Davey Smith, George, additional, Brennan, Paul, additional, and Johansson, Mattias, additional

Published
2022
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165. Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Kliemann, Nathalie, primary, Ould Ammar, Romain, additional, Biessy, Carine, additional, Gicquiau, Audrey, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Sánchez, Maria-Jose, additional, Crous-Bou, Marta, additional, Pasanisi, Fabrizio, additional, Tin Tin, Sandar, additional, Perez-Cornago, Aurora, additional, Aune, Dagfinn, additional, Christakoudi, Sofia, additional, Heath, Alicia K., additional, Colorado-Yohar, Sandra M., additional, Grioni, Sara, additional, Skeie, Guri, additional, Sartor, Hanna, additional, Idahl, Annika, additional, Rylander, Charlotta, additional, May, Anne M., additional, Weiderpass, Elisabete, additional, Freisling, Heinz, additional, Playdon, Mary C., additional, Rinaldi, Sabina, additional, Murphy, Neil, additional, Huybrechts, Inge, additional, Dossus, Laure, additional, and Gunter, Marc J., additional

Published
2022
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166. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Breeur, Marie, primary, Ferrari, Pietro, additional, Dossus, Laure, additional, Jenab, Mazda, additional, Johansson, Mattias, additional, Rinaldi, Sabina, additional, Travis, Ruth C., additional, His, Mathilde, additional, Key, Tim J., additional, Schmidt, Julie A., additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Rothwell, Joseph A., additional, Laouali, Nasser, additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schulze, Matthias B., additional, Eichelmann, Fabian, additional, Palli, Domenico, additional, Grioni, Sara, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Bueno-de-Mesquita, Bas, additional, Olsen, Karina Standahl, additional, Sandanger, Torkjel Manning, additional, Nøst, Therese Haugdahl, additional, Quirós, J. Ramón, additional, Bonet, Catalina, additional, Barranco, Miguel Rodríguez, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Sandsveden, Malte, additional, Manjer, Jonas, additional, Vidman, Linda, additional, Rentoft, Matilda, additional, Muller, David, additional, Tsilidis, Kostas, additional, Heath, Alicia K., additional, Keun, Hector, additional, Adamski, Jerzy, additional, Keski-Rahkonen, Pekka, additional, Scalbert, Augustin, additional, Gunter, Marc J., additional, and Viallon, Vivian, additional

Published
2022
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167. Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study

Author

Fortuin-de Smidt, Melony C, primary, Sewe, Maquins Odhiambo, additional, Lassale, Camille, additional, Weiderpass, Elisabete, additional, Andersson, Jonas, additional, Huerta, José María, additional, Ekelund, Ulf, additional, Aleksandrova, Krasimira, additional, Tong, Tammy YN, additional, Dahm, Christina C, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Steindorf, Karen, additional, Schulze, Matthias B, additional, Katzke, Verena, additional, Sacerdote, Carlotta, additional, Agnoli, Claudia, additional, Masala, Giovanna, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Boer, Jolanda MA, additional, Onland-Moret, N Charlotte, additional, Wendel-Vos, GC Wanda, additional, van der Schouw, Yvonne T, additional, Borch, Kristin Benjaminsen, additional, Agudo, Antonio, additional, Petrova, Dafina, additional, Chirlaque, María Dolores, additional, Conchi, Moreno Iribas, additional, Amiano, Pilar, additional, Melander, Olle, additional, Heath, Alicia K, additional, Aune, Dagfinn, additional, Forouhi, Nita G, additional, Langenberg, Claudia, additional, Brage, Soren, additional, Riboli, Elio, additional, Wareham, Nicholas J, additional, Danesh, John, additional, Butterworth, Adam S, additional, and Wennberg, Patrik, additional

Published
2022
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168. Meat Intake Is Associated with a Higher Risk of Ulcerative Colitis in a Large European Prospective Cohort Studyø

Author

Dong, Catherine, primary, Chan, Simon S M, additional, Jantchou, Prevost, additional, Racine, Antoine, additional, Oldenburg, Bas, additional, Weiderpass, Elisabete, additional, Heath, Alicia K, additional, Tong, Tammy Y N, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Bueno de Mesquita, Bas, additional, Kaaks, Rudolf, additional, Katzke, Verena A, additional, Bergman, Manuela M, additional, Boeing, Heiner, additional, Palli, Domenico, additional, Masala, Giovanna, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Colorado-Yohar, Sandra M, additional, Sánchez, Maria-Jose, additional, Grip, Olof, additional, Lindgren, Stefan, additional, Luben, Robert, additional, Huybrechts, Inge, additional, Gunter, Marc J, additional, Mahamat-Saleh, Yahya, additional, Boutron-Ruault, Marie-Christine, additional, and Carbonnel, Franck, additional

Published
2022
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169. Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition ( EPIC ) study

Author

Clasen, Joanna L, primary, Heath, Alicia K, additional, Van Puyvelde, Heleen, additional, Huybrechts, Inge, additional, Park, Jin Young, additional, Ferrari, Pietro, additional, Scelo, Ghislaine, additional, Ulvik, Arve, additional, Midttun, Øivind, additional, Ueland, Per Magne, additional, Overvad, Kim, additional, Eriksen, Anne Kirstine, additional, Tjønneland, Anne, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schulze, Matthias B, additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Chiodini, Paolo, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Zamora‐Ros, Raul, additional, Rodriguez‐Barranco, Miguel, additional, Santiuste, Carmen, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Schmidt, Julie A, additional, Weiderpass, Elisabete, additional, Gunter, Marc, additional, Riboli, Elio, additional, Cross, Amanda J, additional, Johansson, Mattias, additional, and Muller, David C, additional

Published
2022
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170. A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC

Author

Papadimitriou, Nikos, primary, Bouras, Emmanouil, additional, van den Brandt, Piet A., additional, Muller, David C., additional, Papadopoulou, Areti, additional, Heath, Alicia K., additional, Critselis, Elena, additional, Gunter, Marc J., additional, Vineis, Paolo, additional, Ferrari, Pietro, additional, Weiderpass, Elisabete, additional, Boeing, Heiner, additional, Bastide, Nadia, additional, Merritt, Melissa A., additional, Lopez, David S., additional, Bergmann, Manuela M., additional, Perez-Cornago, Aurora, additional, Schulze, Matthias, additional, Skeie, Guri, additional, Srour, Bernard, additional, Eriksen, Anne Kirstine, additional, Boden, Stina, additional, Johansson, Ingegerd, additional, Nøst, Therese Haugdahl, additional, Lukic, Marco, additional, Ricceri, Fulvio, additional, Ericson, Ulrika, additional, Huerta, José María, additional, Dahm, Christina C., additional, Agnoli, Claudia, additional, Amiano, Pilar Exezarreta, additional, Tjønneland, Anne, additional, Gurrea, Aurelio Barricarte, additional, Bueno-de-Mesquita, Bas, additional, Ardanaz, Eva, additional, Berntsson, Jonna, additional, Sánchez, Maria-Jose, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Katzke, Verena, additional, Jakszyn, Paula, additional, Masala, Giovanna, additional, Derksen, Jeroen W.G., additional, Quirós, J. Ramón, additional, Severi, Gianluca, additional, Cross, Amanda J., additional, Riboli, Ellio, additional, Tzoulaki, Ioanna, additional, and Tsilidis, Konstantinos K., additional

Published
2022
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171. Additional file 1 of Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian

Abstract

Additional file 1. Supplementary material regarding (i) the definition of cancer cases for HCC, GBC, Adv.PrC and Loc.PrC; (ii) the definition and implementation of the data-shared lasso; (iii) the models used to derive point estimates and confidence intervals from the model selected by the data-shared lasso; and (iv) the univariate analysis conducted for comparison.

Published
2022
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172. Additional file 2 of Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Author

Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Eichelmann, Fabian, Palli, Domenico, Grioni, Sara, Panico, Salvatore, Tumino, Rosario, Sacerdote, Carlotta, Bueno-de-Mesquita, Bas, Olsen, Karina Standahl, Sandanger, Torkjel Manning, Nøst, Therese Haugdahl, Quirós, J. Ramón, Bonet, Catalina, Barranco, Miguel Rodríguez, Chirlaque, María-Dolores, Ardanaz, Eva, Sandsveden, Malte, Manjer, Jonas, Vidman, Linda, Rentoft, Matilda, Muller, David, Tsilidis, Kostas, Heath, Alicia K., Keun, Hector, Adamski, Jerzy, Keski-Rahkonen, Pekka, Scalbert, Augustin, Gunter, Marc J., and Viallon, Vivian

Abstract

Additional file 2: Supplementary tables and figures. Figure S1. Pearson correlation between the 117 original metabolites. Figure S2. Sensitivity analyses of mutually adjusted ORs for the overall associations and cancer type-specific deviations. Figure S3. Sensitivity analysis of mutually adjusted ORs for the overall associations and cancer type-specific deviations with or without excluding hormone users. Figure S4. p-values of tests for departure from linearity and effect modification by BMI. Figure S5. ORs for the overall associations identified by the data-shared lasso with (i) the original model (ii) the extended type-specific model. Figure S6. Results from the univariate analyses. Figure S7. Comparison of the associations identified by the data-shared lasso when working with the 50 features (as in our main analysis) or with the original 117 metabolites. Figure S8. Pearson correlation between the 50 clusters. Figure S9. Pearson correlation between the 19 features related to at least one cancer site in our main analysis. Table S1. list of the 117 metabolites studied in the main analysis, and of the 16 additional metabolites studied when excluding the second colorectal study. Table S2. Robustness of the associations identified in the main analysis when including all the pairs from the prostate cancer study. Table S3. Other associations identified in a large proportion of bootstrap samples when including all the pairs from the prostate cancer study.

Published
2022
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174. Inflammatory potential of diet and pancreatic cancer risk in the EPIC study

Author

Cayssials, Valerie, primary, Buckland, Genevieve, additional, Crous-Bou, Marta, additional, Bonet, Catalina, additional, Weiderpass, Elisabete, additional, Skie, Guri, additional, Aune, Dagfinn, additional, Heath, Alicia, additional, Nøst, Therese Haugdahl, additional, Masala, Giovanna, additional, Agnoli, Claudia, additional, De Magistris, Maria Santucci, additional, Bueno-de-Mesquita, Bas, additional, Derksen, Jeroen, additional, Huybrechts, Inge, additional, Ferrari, Pietro, additional, Franklin, Oscar, additional, Bodén, Stina, additional, Schulze, Matthias, additional, Huerta, Jose Maria, additional, Barricarte, Aurelio, additional, Sacerdote, Carlotta, additional, Amiano, Pilar, additional, Tumino, Rosario, additional, Molina-Montes, Esther, additional, Tjønneland, Anne, additional, Kyrø, Cecilie, additional, Severi, Gianluca, additional, Boutron-Ruault, Marie-Christine, additional, Rebours, Vinciane, additional, Katzke, Verena, additional, Agudo, Antonio, additional, and Jakszyn, Paula, additional

Published
2022
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175. Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer

Author

Mukama, Trasias, primary, Fortner, Renée Turzanski, additional, Katzke, Verena, additional, Hynes, Lucas Cory, additional, Petrera, Agnese, additional, Hauck, Stefanie M., additional, Johnson, Theron, additional, Schulze, Matthias, additional, Schiborn, Catarina, additional, Rostgaard-Hansen, Agnetha Linn, additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Pérez, María José Sánchez, additional, Crous-Bou, Marta, additional, Chirlaque, María-Dolores, additional, Amiano, Pilar, additional, Ardanaz, Eva, additional, Watts, Eleanor L., additional, Travis, Ruth C., additional, Sacerdote, Carlotta, additional, Grioni, Sara, additional, Masala, Giovanna, additional, Signoriello, Simona, additional, Tumino, Rosario, additional, Gram, Inger T., additional, Sandanger, Torkjel M., additional, Sartor, Hanna, additional, Lundin, Eva, additional, Idahl, Annika, additional, Heath, Alicia K., additional, Dossus, Laure, additional, Weiderpass, Elisabete, additional, and Kaaks, Rudolf, additional

Published
2022
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176. RETRACTED: Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Author

Sofianopoulou, Eleni, Kaptoge, Stephen K, Afzal, Shoaib, Jiang, Tao, Gill, Dipender, Gundersen, Thomas E, Bolton, Thomas R, Allara, Elias, Arnold, Matthew G, Mason, Amy M, Chung, Ryan, Pennells, Lisa A M, Shi, Fanchao, Sun, Luanluan, Willeit, Peter, Forouhi, Nita G, Langenberg, Claudia, Sharp, Stephen J, Panico, Salvatore, Engström, Gunnar, Melander, Olle, Tong, Tammy Y N, Perez-Cornago, Aurora, Norberg, Margareta, Johansson, Ingegerd, Katzke, Verena, Srour, Bernard, José Sánchez, María, Redondo-Sánchez, Daniel, Olsen, Anja, Dahm, Christina C, Overvad, Kim, Brustad, Magritt, Skeie, Guri, Moreno-Iribas, Conchi, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Tsilidis, Konstantinos K, Heath, Alicia K, Agnoli, Claudia, Krogh, Vittorio, de Boer, Ian H, Kobylecki, Camilla Jannie, Çolak, Yunus, Zittermann, Armin, Sundström, Johan, Welsh, Paul, Weiderpass, Elisabete, Aglago, Elom K, Ferrari, Pietro, Clarke, Robert, Boutron, Marie-Christine, Severi, Gianluca, MacDonald, Conor, Providencia, Rui, Masala, Giovanna, Zamora Ros, Raul, Boer, Jolanda, Verschuren, WM Monique, Cawthon, Peggy, Schierbeck, Louise L, Cooper, Cyrus, Schulze, Matthias B, Bergmann, Manuela M, Hannemann, Anke, Kiechl, Stefan, Brenner, Hermann, van Schoor, Natasja M, Albertorio, Juan R, Sacerdote, Carlotta, Linneberg, Allan, Kårhus, Line L, Huerta, José María, Imaz, Liher, Joergensen, Christel, Ben-Shlomo, Yoav, Lundqvist, Annamari, Gallacher, John, Sattar, Naveed, Wood, Angela M, Wareham, Nicholas J, Nordestgaard, Børge G, Di Angelantonio, Emanuele, Danesh, John, Butterworth, Adam S, and Burgess, Stephen

Published
2021
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177. Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease: Findings From the EPIC‐CVD Case‐Cohort Study Across Nine European Countries

Author

Steur, Marinka, primary, Johnson, Laura, additional, Sharp, Stephen J., additional, Imamura, Fumiaki, additional, Sluijs, Ivonne, additional, Key, Timothy J., additional, Wood, Angela, additional, Chowdhury, Rajiv, additional, Guevara, Marcela, additional, Jakobsen, Marianne U., additional, Johansson, Ingegerd, additional, Koulman, Albert, additional, Overvad, Kim, additional, Sánchez, Maria‐José, additional, van der Schouw, Yvonne T., additional, Trichopoulou, Antonia, additional, Weiderpass, Elisabete, additional, Wennberg, Maria, additional, Zheng, Ju‐Sheng, additional, Boeing, Heiner, additional, Boer, Jolanda M. A., additional, Boutron‐Ruault, Marie‐Christine, additional, Ericson, Ulrika, additional, Heath, Alicia K., additional, Huybrechts, Inge, additional, Imaz, Liher, additional, Kaaks, Rudolf, additional, Krogh, Vittorio, additional, Kühn, Tilman, additional, Kyrø, Cecilie, additional, Masala, Giovanna, additional, Melander, Olle, additional, Moreno‐Iribas, Conchi, additional, Panico, Salvatore, additional, Quirós, José R., additional, Rodríguez‐Barranco, Miguel, additional, Sacerdote, Carlotta, additional, Santiuste, Carmen, additional, Skeie, Guri, additional, Tjønneland, Anne, additional, Tumino, Rosario, additional, Verschuren, W. M. Monique, additional, Zamora‐Ros, Raul, additional, Dahm, Christina C., additional, Perez‐Cornago, Aurora, additional, Schulze, Matthias B., additional, Tong, Tammy Y. N., additional, Riboli, Elio, additional, Wareham, Nicholas J., additional, Danesh, John, additional, Butterworth, Adam S., additional, and Forouhi, Nita G., additional

Published
2021
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178. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Author

Sofianopoulou, Eleni, primary, Kaptoge, Stephen K, additional, Afzal, Shoaib, additional, Jiang, Tao, additional, Gill, Dipender, additional, Gundersen, Thomas E, additional, Bolton, Thomas R, additional, Allara, Elias, additional, Arnold, Matthew G, additional, Mason, Amy M, additional, Chung, Ryan, additional, Pennells, Lisa A M, additional, Shi, Fanchao, additional, Sun, Luanluan, additional, Willeit, Peter, additional, Forouhi, Nita G, additional, Langenberg, Claudia, additional, Sharp, Stephen J, additional, Panico, Salvatore, additional, Engström, Gunnar, additional, Melander, Olle, additional, Tong, Tammy Y N, additional, Perez-Cornago, Aurora, additional, Norberg, Margareta, additional, Johansson, Ingegerd, additional, Katzke, Verena, additional, Srour, Bernard, additional, José Sánchez, María, additional, Redondo-Sánchez, Daniel, additional, Olsen, Anja, additional, Dahm, Christina C, additional, Overvad, Kim, additional, Brustad, Magritt, additional, Skeie, Guri, additional, Moreno-Iribas, Conchi, additional, Onland-Moret, N Charlotte, additional, van der Schouw, Yvonne T, additional, Tsilidis, Konstantinos K, additional, Heath, Alicia K, additional, Agnoli, Claudia, additional, Krogh, Vittorio, additional, de Boer, Ian H, additional, Kobylecki, Camilla Jannie, additional, Çolak, Yunus, additional, Zittermann, Armin, additional, Sundström, Johan, additional, Welsh, Paul, additional, Weiderpass, Elisabete, additional, Aglago, Elom K, additional, Ferrari, Pietro, additional, Clarke, Robert, additional, Boutron, Marie-Christine, additional, Severi, Gianluca, additional, MacDonald, Conor, additional, Providencia, Rui, additional, Masala, Giovanna, additional, Zamora Ros, Raul, additional, Boer, Jolanda, additional, Verschuren, WM Monique, additional, Cawthon, Peggy, additional, Schierbeck, Louise L, additional, Cooper, Cyrus, additional, Schulze, Matthias B, additional, Bergmann, Manuela M, additional, Hannemann, Anke, additional, Kiechl, Stefan, additional, Brenner, Hermann, additional, van Schoor, Natasja M, additional, Albertorio, Juan R, additional, Sacerdote, Carlotta, additional, Linneberg, Allan, additional, Kårhus, Line L, additional, Huerta, José María, additional, Imaz, Liher, additional, Joergensen, Christel, additional, Ben-Shlomo, Yoav, additional, Lundqvist, Annamari, additional, Gallacher, John, additional, Sattar, Naveed, additional, Wood, Angela M, additional, Wareham, Nicholas J, additional, Nordestgaard, Børge G, additional, Di Angelantonio, Emanuele, additional, Danesh, John, additional, Butterworth, Adam S, additional, and Burgess, Stephen, additional

Published
2021
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179. Mediating Role of Lifestyle Behaviors in the Association between Education and Cancer: Results from the European Prospective Investigation into Cancer and Nutrition.

Author

Macciotta, Alessandra, Catalano, Alberto, Giraudo, Maria Teresa, Weiderpass, Elisabete, Ferrari, Pietro, Freisling, Heinz, Colorado-Yohar, Sandra M., Santiuste, Carmen, Amiano, Pilar, Heath, Alicia K., Ward, Heather A., Christakoudi, Sofia, Vineis, Paolo, Singh, Deependra, Vaccarella, Salvatore, Schulze, Matthias B., Hiensch, Anouk E., Monninkhof, Evelyn M., Katzke, Verena, and Kaaks, Rudolf

Abstract

Background: Many studies have shown that socioeconomic position (SEP) is associated with the incidence of malignant tumors at different sites. This study aims to estimate the association between educational level (as proxy for SEP) and cancer incidence and to understand whether the observed associations might be partially explained by lifestyle behaviors. Methods: The analyses were performed on data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, globally and by sex. We used Cox proportional hazards models together with mediation analysis to disentangle the total effect (TE) of educational level [measured through the Relative Index of Inequality (RII)] on cancer incidence into pure direct (PDE) and total indirect (TIE) effect, unexplained and explained by mediators, respectively. PDE and TIE were then combined to compute the proportions mediated (PM). Results: After an average of 14 years of follow-up, 52,422 malignant tumors were ascertained. Low educated participants showed higher risk of developing stomach, lung, kidney (in women), and bladder (in men) cancers, and, conversely, lower risk of melanoma and breast cancer (in post-menopausal women), when compared with more educated participants. Mediation analyses showed that portions of the TE of RII on cancer could be explained by site-specific related lifestyle behaviors for stomach, lung, and breast (in women). Conclusions: Cancer incidence in Europe is determined at least in part by a socioeconomically stratified distribution of risk factors. Impact: These observational findings support policies to reduce cancer occurrence by altering mediators, such as lifestyle behaviors, particularly focusing on underprivileged strata of the population. [ABSTRACT FROM AUTHOR]

Published
2023
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180. Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes

Author

Ried Larsen, Mathias, Rasmussen, Martin Gillies, Blond, Kim, Overvad, Thure F., Overvad, Kim, Steindorf, Karen, Katzke, Verena, Andersen, Julie L. M., Petersen, Kristina E. N., Aune, Dagfinn, Tsilidis, Kostas K., Heath, Alicia K., Papier, Keren, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Weiderpass, Elisabete, Freisling, Heinz, Bergmann, Manuela M., Verschuren, W. M. Monique, Zamora-Ros, Raul, Colorado Yohar, Sandra M., Spijkerman, Annemieke M. W., Schulze, Matthias B., Ardanaz, Eva M. A., Andersen, Lars Bo, Wareham, Nick, Brage, Søren, and Grøntved, Anders

Subjects
Diabetis, Cardiovascular diseases, Malalties cardiovasculars, Diabetes
Abstract

Importance: Premature death from all causes and cardiovascular disease (CVD) causes is higher among persons with diabetes. Objective: To investigate the association between time spent cycling and all-cause and CVD mortality among persons with diabetes, as well as to evaluate the association between change in time spent cycling and risk of all-cause and CVD mortality. Design, setting, and participants: This prospective cohort study included 7459 adults with diabetes from the European Prospective Investigation into Cancer and Nutrition study. Questionnaires regarding medical history, sociodemographic, and lifestyle information were administered in 10 Western European countries from 1992 through 2000 (baseline examination) and at a second examination 5 years after baseline. A total of 5423 participants with diabetes completed both examinations. The final updated primary analysis was conducted on November 13, 2020. Exposures: The primary exposure was self-reported time spent cycling per week at the baseline examination. The secondary exposure was change in cycling status from baseline to the second examination. Main outcomes and measures: The primary and secondary outcomes were all-cause and CVD mortality, respectively, adjusted for other physical activity modalities, diabetes duration, and sociodemographic and lifestyle factors. Results: Of the 7459 adults with diabetes included in the analysis, the mean (SD) age was 55.9 (7.7) years, and 3924 (52.6%) were female. During 110 944 person-years of follow-up, 1673 deaths from all causes were registered. Compared with the reference group of people who reported no cycling at baseline (0 min/wk), the multivariable-adjusted hazard ratios for all-cause mortality were 0.78 (95% CI, 0.61-0.99), 0.76 (95% CI, 0.65-0.88), 0.68 (95% CI, 0.57-0.82), and 0.76 (95% CI, 0.63-0.91) for cycling 1 to 59, 60 to 149, 150 to 299, and 300 or more min/wk, respectively. In an analysis of change in time spent cycling with 57 802 person-years of follow-up, a total of 975 deaths from all causes were recorded. Compared with people who reported no cycling at both examinations, the multivariable-adjusted hazard ratios for all-cause mortality were 0.90 (95% CI, 0.71-1.14) in those who cycled and then stopped, 0.65 (95% CI, 0.46-0.92) in initial noncyclists who started cycling, and 0.65 (95% CI, 0.53-0.80) for people who reported cycling at both examinations. Similar results were observed for CVD mortality. Conclusion and relevance: In this cohort study, cycling was associated with lower all-cause and CVD mortality risk among people with diabetes independent of practicing other types of physical activity. Participants who took up cycling between the baseline and second examination had a considerably lower risk of both all-cause and CVD mortality compared with consistent noncyclists.

Published
2021

181. Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations

Author

Baker, Jacqueline Roshelli, primary, Umesh, Sushma, additional, Jenab, Mazda, additional, Schomburg, Lutz, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Boutron-Ruault, Marie-Christine, additional, Rothwell, Joseph A., additional, Severi, Gianluca, additional, Katzke, Verena, additional, Johnson, Theron, additional, Schulze, Matthias B., additional, Masala, Giovanna, additional, Agnoli, Claudia, additional, Simeon, Vittorio, additional, Tumino, Rosario, additional, Bueno-de-Mesquita, H. Bas, additional, Gram, Inger Torhild, additional, Skeie, Guri, additional, Bonet, Catalina, additional, Rodriguez-Barranco, Miguel, additional, Houerta, José María, additional, Gylling, Björn, additional, Van Guelpen, Bethany, additional, Perez-Cornago, Aurora, additional, Aglago, Elom, additional, Freisling, Heinz, additional, Weiderpass, Elisabete, additional, Cross, Amanda J., additional, Heath, Alicia K., additional, Hughes, David J., additional, and Fedirko, Veronika, additional

Published
2021
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182. Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Author

Aglago, Elom K., primary, Mayén, Ana-Lucia, additional, Knaze, Viktoria, additional, Freisling, Heinz, additional, Fedirko, Veronika, additional, Hughes, David J., additional, Jiao, Li, additional, Eriksen, Anne Kirstine, additional, Tjønneland, Anne, additional, Boutron-Ruault, Marie-Christine, additional, Rothwell, Joseph A., additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schulze, Matthias B., additional, Birukov, Anna, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Santucci de Magistris, Maria, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Bueno-de-Mesquita, Bas, additional, Derksen, Jeroen W. G., additional, Skeie, Guri, additional, Gram, Inger Torhild, additional, Sandanger, Torkjel, additional, Quirós, J. Ramón, additional, Luján-Barroso, Leila, additional, Sánchez, Maria-Jose, additional, Amiano, Pilar, additional, Chirlaque, María-Dolores, additional, Gurrea, Aurelio Barricarte, additional, Johansson, Ingegerd, additional, Manjer, Jonas, additional, Perez-Cornago, Aurora, additional, Weiderpass, Elisabete, additional, Gunter, Marc J., additional, Heath, Alicia K., additional, Schalkwijk, Casper G., additional, and Jenab, Mazda, additional

Published
2021
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184. Association of Cycling With All-Cause and Cardiovascular Disease Mortality Among Persons With Diabetes

Author

Ried-Larsen, Mathias, primary, Rasmussen, Martin Gillies, additional, Blond, Kim, additional, Overvad, Thure F., additional, Overvad, Kim, additional, Steindorf, Karen, additional, Katzke, Verena, additional, Andersen, Julie L. M., additional, Petersen, Kristina E. N., additional, Aune, Dagfinn, additional, Tsilidis, Kostas K., additional, Heath, Alicia K., additional, Papier, Keren, additional, Panico, Salvatore, additional, Masala, Giovanna, additional, Pala, Valeria, additional, Weiderpass, Elisabete, additional, Freisling, Heinz, additional, Bergmann, Manuela M., additional, Verschuren, W. M. Monique, additional, Zamora-Ros, Raul, additional, Colorado-Yohar, Sandra M., additional, Spijkerman, Annemieke M. W., additional, Schulze, Matthias B., additional, Ardanaz, Eva M. A., additional, Andersen, Lars Bo, additional, Wareham, Nick, additional, Brage, Søren, additional, and Grøntved, Anders, additional

Published
2021
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185. Consumption of ultra-processed foods associated with weight gain and obesity in adults: A multi-national cohort study

Author

Cordova, Reynalda, primary, Kliemann, Nathalie, additional, Huybrechts, Inge, additional, Rauber, Fernanda, additional, Vamos, Eszter P., additional, Levy, Renata Bertazzi, additional, Wagner, Karl-Heinz, additional, Viallon, Vivian, additional, Casagrande, Corinne, additional, Nicolas, Geneviève, additional, Dahm, Christina C., additional, Zhang, Jie, additional, Halkjær, Jytte, additional, Tjønneland, Anne, additional, Boutron-Ruault, Marie-Christine, additional, Mancini, Francesca Romana, additional, Laouali, Nasser, additional, Katzke, Verena, additional, Srour, Bernard, additional, Jannasch, Franziska, additional, Schulze, Matthias B., additional, Masala, Giovanna, additional, Grioni, Sara, additional, Panico, Salvatore, additional, van der Schouw, Yvonne T., additional, Derksen, Jeroen W.G., additional, Rylander, Charlotta, additional, Skeie, Guri, additional, Jakszyn, Paula, additional, Rodriguez-Barranco, Miguel, additional, Huerta, José María, additional, Barricarte, Aurelio, additional, Brunkwall, Lousie, additional, Ramne, Stina, additional, Bodén, Stina, additional, Perez-Cornago, Aurora, additional, Heath, Alicia K., additional, Vineis, Paolo, additional, Weiderpass, Elisabete, additional, Monteiro, Carlos Augusto, additional, Gunter, Marc J., additional, Millett, Christopher, additional, and Freisling, Heinz, additional

Published
2021
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187. Prospective analysis of circulating metabolites and endometrial cancer risk

Author

Dossus, Laure, primary, Kouloura, Eirini, additional, Biessy, Carine, additional, Viallon, Vivian, additional, Siskos, Alexandros P., additional, Dimou, Niki, additional, Rinaldi, Sabina, additional, Merritt, Melissa A., additional, Allen, Naomi, additional, Fortner, Renee, additional, Kaaks, Rudolf, additional, Weiderpass, Elisabete, additional, Gram, Inger T., additional, Rothwell, Joseph A., additional, Lécuyer, Lucie, additional, Severi, Gianluca, additional, Schulze, Matthias B., additional, Nøst, Therese Haugdahl, additional, Crous-Bou, Marta, additional, Sánchez, Maria-Jose, additional, Amiano, Pilar, additional, Colorado-Yohar, Sandra M., additional, Gurrea, Aurelio Barricarte, additional, Schmidt, Julie A., additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Mattiello, Amalia, additional, Vermeulen, Roel, additional, Heath, Alicia K., additional, Christakoudi, Sofia, additional, Tsilidis, Konstantinos K., additional, Travis, Ruth C., additional, Gunter, Marc J., additional, and Keun, Hector C., additional

Published
2021
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188. Food processing and cancer risk in Europe: results from the prospective EPIC cohort study

Author

Kliemann, Nathalie, Rauber, Fernanda, Bertazzi Levy, Renata, Viallon, Vivian, Vamos, Eszter P, Cordova, Reynalda, Freisling, Heinz, Casagrande, Corinne, Nicolas, Genevieve, Aune, Dagfinn, Tsilidis, Konstantinos K, Heath, Alicia, Schulze, Matthias B, Jannasch, Franziska, Srour, Bernard, Kaaks, Rudolf, Rodriguez-Barranco, Miguel, Tagliabue, Giovanna, Agudo, Antonio, Panico, Salvatore, Ardanaz, Eva, Chirlaque, María-Dolores, Vineis, Paolo, Tumino, Rosario, Perez-Cornago, Aurora, Andersen, Julie Louise Munk, Tjønneland, Anne, Skeie, Guri, Weiderpass, Elisabete, Monteiro, Carlos Augusto, Gunter, Marc J, Millett, Christopher, and Huybrechts, Inge

Abstract

Food processing has been hypothesised to play a role in cancer development; however, data from large-scale epidemiological studies are scarce. This study investigated the association between dietary intake according to amount of food processing and risk of cancer at 25 anatomical sites using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Published
2023
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189. Plasma concentrations of persistent organic pollutants and pancreatic cancer risk

Author

Porta, Miquel, primary, Gasull, Magda, additional, Pumarega, José, additional, Kiviranta, Hannu, additional, Rantakokko, Panu, additional, Raaschou-Nielsen, Ole, additional, Bergdahl, Ingvar A, additional, Sandanger, Torkjel Manning, additional, Agudo, Antoni, additional, Rylander, Charlotta, additional, Nøst, Therese Haugdahl, additional, Donat-Vargas, Carolina, additional, Aune, Dagfinn, additional, Heath, Alicia K, additional, Cirera, Lluís, additional, Goñi-Irigoyen, Fernando, additional, Alguacil, Juan, additional, Giménez-Robert, Àlex, additional, Tjønneland, Anne, additional, Sund, Malin, additional, Overvad, Kim, additional, Mancini, Francesca Romana, additional, Rebours, Vinciane, additional, Boutron-Ruault, Marie-Christine, additional, Kaaks, Rudolf, additional, Schulze, Matthias B, additional, Trichopoulou, Antonia, additional, Palli, Domenico, additional, Grioni, Sara, additional, Tumino, Rosario, additional, Naccarati, Alessio, additional, Panico, Salvatore, additional, Vermeulen, Roel, additional, Quirós, J Ramón, additional, Rodríguez-Barranco, Miguel, additional, Colorado-Yohar, Sandra M, additional, Chirlaque, María-Dolores, additional, Ardanaz, Eva, additional, Wareham, Nick, additional, Key, Tim, additional, Johansson, Mattias, additional, Murphy, Neil, additional, Ferrari, Pietro, additional, Huybrechts, Inge, additional, Chajes, Veronique, additional, Gonzalez, Carlos Alberto, additional, Bueno-de-Mesquita, Bas, additional, Gunter, Marc, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, Duell, Eric J, additional, Katzke, Verena, additional, and Vineis, Paolo, additional

Published
2021
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190. A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Clasen, Joanna L, primary, Heath, Alicia K, additional, Van Puyvelde, Heleen, additional, Huybrechts, Inge, additional, Park, Jin Young, additional, Ferrari, Pietro, additional, Johansson, Mattias, additional, Scelo, Ghislaine, additional, Ulvik, Arve, additional, Midttun, Øivind, additional, Ueland, Per Magne, additional, Dahm, Christina C, additional, Halkjær, Jytte, additional, Olsen, Anja, additional, Johnson, Theron, additional, Katzke, Verena, additional, Schulze, Matthias B, additional, Masala, Giovanna, additional, Segrado, Francesco, additional, de Magistris, Maria Santucci, additional, Sacerdote, Carlotta, additional, Ocké, Marga C, additional, Luján-Barroso, Leila, additional, Ching-López, Ana, additional, Huerta, José María, additional, Ardanaz, Eva, additional, Amiano, Pilar, additional, Ericson, Ulrika, additional, Manjer, Jonas, additional, Gylling, Björn, additional, Johansson, Ingegerd, additional, Schmidt, Julie, additional, Weiderpass, Elisabete, additional, Riboli, Elio, additional, Cross, Amanda J, additional, and Muller, David C, additional

Published
2021
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191. Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Van Puyvelde, Heleen, primary, Papadimitriou, Nikos, additional, Clasen, Joanna, additional, Muller, David, additional, Biessy, Carine, additional, Ferrari, Pietro, additional, Halkjær, Jytte, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Fortner, Renée T., additional, Katzke, Verena, additional, Schulze, Matthias B., additional, Chiodini, Paolo, additional, Masala, Giovanna, additional, Pala, Valeria, additional, Sacerdote, Carlotta, additional, Tumino, Rosario, additional, Bakker, Marije F., additional, Agudo, Antonio, additional, Ardanaz, Eva, additional, Chirlaque López, María Dolores, additional, Sánchez, Maria-Jose, additional, Ericson, Ulrika, additional, Gylling, Björn, additional, Karlsson, Therese, additional, Manjer, Jonas, additional, Schmidt, Julie A., additional, Nicolas, Geneviève, additional, Casagrande, Corinne, additional, Weiderpass, Elisabete, additional, Heath, Alicia K., additional, Godderis, Lode, additional, Van Herck, Koen, additional, De Bacquer, Dirk, additional, Gunter, Marc J., additional, and Huybrechts, Inge, additional

Published
2021
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192. Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Aglago, Elom K., primary, Murphy, Neil, additional, Huybrechts, Inge, additional, Nicolas, Geneviève, additional, Casagrande, Corinne, additional, Fedirko, Veronika, additional, Weiderpass, Elisabete, additional, Rothwell, Joseph A., additional, Dahm, Christina C., additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schulze, Matthias B., additional, Masala, Giovanna, additional, Agnoli, Claudia, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Bueno‐de‐Mesquita, Bas H., additional, Derksen, Jeroen W. G., additional, Skeie, Guri, additional, Gram, Inger Torhild, additional, Brustad, Magritt, additional, Jakszyn, Paula, additional, Sánchez, Maria‐Jose, additional, Amiano, Pilar, additional, Huerta, José María, additional, Ericson, Ulrika, additional, Wennberg, Maria, additional, Perez‐Cornago, Aurora, additional, Heath, Alicia K., additional, Jenab, Mazda, additional, Chajes, Veronique, additional, and Gunter, Marc J., additional

Published
2021
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193. Additional file 1 of Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition

Author

Kliemann, Nathalie, Viallon, Vivian, Murphy, Neil, Beeken, Rebecca J., Rothwell, Joseph A., Rinaldi, Sabina, Assi, Nada, Van Roekel, Eline H., Schmidt, Julie A., Borch, Kristin Benjaminsen, Agnoli, Claudia, Rosendahl, Ann H., Sartor, Hanna, Huerta, José María, Tjønneland, Anne, Halkjær, Jytte, Bueno-De-Mesquita, Bas, Gicquiau, Audrey, Achaintre, David, Aleksandrova, Krasimira, Schulze, Matthias B., Heath, Alicia K., Tsilidis, Konstantinos K., Masala, Giovanna, Panico, Salvatore, Kaaks, Rudolf, Fortner, Renée T., Van Guelpen, Bethany, Dossus, Laure, Scalbert, Augustin, Keun, Hector C., Travis, Ruth C., Mazda Jenab, Johansson, Mattias, Ferrari, Pietro, and Gunter, Marc J.

Abstract

Additional file 1: Supplementary information. Table S1. Number of metabolites included in each study population; Table S2. Metabolites associated with each anthropometric variable in the replication set; Table S3. Metabolites with the greatest contribution for each metabolic signature; Table S4. Correlations between the metabolic signatures and their corresponding anthropometric measure; Table S5. Metabolites that changed significantly from baseline to follow-up in the Intercept; Table S6. Metabolites significantly associated with weight loss in the Intercept; Table S7. Metabolites significantly associated with weight loss in the Intercept; Figure S1. Overall Rpartial2 and weighted Rpartial2 for each covariate and BMI in the discovery set; Figure S2. Overall Rpartial2 and weighted Rpartial2 for each covariate and WC in the discovery set; Figure S3. Overall Rpartial2 and weighted Rpartial2 for each covariate and WHR in the discovery set; Figure S4. Overall Rpartial2 and weighted Rpartial2 for each covariate and weight loss in the Intercept; Figure S5. Association of colorectal and endometrial cancers with the metabolic signatures further adjusted to C-peptide; Figure S6. Association of colorectal and endometrial cancers with the anthropometric measures of obesity; Figure S7. Smile plot of the associations between metabolites with weight loss in the Intercept.

Published
2021
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194. Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Ellingjord-Dale, Merete, Christakoudi, Sofia, Weiderpass, Elisabete, Panico, Salvatore, Dossus, Laure, Olsen, Anja, Tjonneland, Anne, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Gram, Inger T., Skeie, Guri, Rosendahl, Ann H., Sund, Malin, Key, Tim, Ferrari, Pietro, Gunter, Marc, Heath, Alicia K., Tsilidis, Konstantinos K., Riboli, Elio, Jose Sanchez, Maria, Chirlaque Lopez, Maria Dolores, Peppa, Eleni, Trichopoulou, Antonia, Martimianaki, Georgia, Agudo, Antonio, Santiuste, Carmen, Ardanaz, Eva, Amiano, Pilar, Boutron-Ruault, Marie-Christine, Simeon, Vittorio, Berrino, Franco, Tumino, Rosario, Severi, Gianluca, Stocks, Tanja, Turzanski-Fortner, Renee, Aleksandrova, Krasimira, Rylander, Charlotta, Aune, Dagfinn, Dahm, Christina C., Department of Surgery, and HUS Abdominal Center

Subjects
0301 basic medicine, Epidemiology, medicine.medical_treatment, Weight Gain, Body Mass Index, 0302 clinical medicine, Risk Factors, Prospective Studies, skin and connective tissue diseases, Public, Environmental & Occupational Health, 2. Zero hunger, Obstetrics, Hazard ratio, 0104 Statistics, Hormone replacement therapy (menopause), General Medicine, Middle Aged, EARLY ADULTHOOD, 3142 Public health care science, environmental and occupational health, 3. Good health, European Prospective Investigation into Cancer and Nutrition, Additional Authors, long-term weight change, POSTMENOPAUSAL WOMEN, 030220 oncology & carcinogenesis, OBESITY, Obesitat, Female, medicine.symptom, Life Sciences & Biomedicine, Cohort study, Adult, medicine.medical_specialty, MENOPAUSE, Breast Neoplasms, SEX STEROIDS, Càncer de mama, 1117 Public Health and Health Services, Young Adult, 03 medical and health sciences, Breast cancer, breast cancer, BODY FATNESS, medicine, cohort study, Humans, AcademicSubjects/MED00860, VALIDITY, Science & Technology, OVERWEIGHT, business.industry, Kirurgi, Weight change, ANTHROPOMETRIC MEASURES, medicine.disease, 030104 developmental biology, Surgery, GAIN, business, Weight gain, Body mass index
Abstract

The coordination of EPIC is financially supported by the European Commission (DG-SANCO) and the International Agency for Research on Cancer. The national cohorts are supported by the Danish Cancer Society (Kræftens Bekæmpelse) (Denmark), German Cancer Aid (Deutsche Krebshilfe), German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), Federal Ministry of Education and Research (Bundesministerium fu¨ r Bildung und Forschung, BMBF) (Germany), Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy), Swedish Cancer Society (Cancerfonden), Swedish Research Council (Vetenskapsra° det), County Councils of Ska°ne and Va¨sterbotten (Sweden), Cancer Research UK (14136 to EPIC-Norfolk; C570/ A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPICOxford) (UK). Infrastructure support for the Department of Epidemiology and Biostatistics at Imperial College London (UK) was provided by the NIHR Imperial Biomedical Research Centre (BRC). The funders had no role in the design and conduct of the study; the collection, analysis and interpretation of the data; or the preparation, review and approval of the manuscript; or in the decision to submit the manuscript for publication., Background: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (HRT) and hormone-receptor status. Methods: Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer. Results: In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years (standard deviation¼3.9) during which 6532 breast-cancer cases occurred. Compared with women with stable weight (62.5 kg), long-term weight gain >10 kg was positively associated with postmenopausal breast-cancer risk in women who were lean at age 20 [hazard ratio (HR)¼1.42; 95% confidence interval 1.22–1.65] in ever HRT users (HR¼1.23; 1.04–1.44), in never HRT users (HR¼1.40; 1.16–1.68) and in oestrogen-and-progesterone-receptor-positive (ERþPRþ) breast cancer (HR¼1.46; 1.15–1.85). Conclusion: Long-term weight gain was positively associated with postmenopausal breast cancer in women who were lean at age 20, both in HRT ever users and non-users, and hormone-receptor-positive breast cancer., European Commission (DG-SANCO), International Agency for Research on Cancer, Danish Cancer Society (Kraftens Bekampelse), German Cancer Aid, German Cancer Research Center, Federal Ministry of Education and Research, Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council, Swedish Cancer Society, Swedish Research Council, County Councils of Skane and Vasterbotten, 14136 Cancer Research UK, C570/A16491 EPIC-Norfolk, 1000143 Medical Research Council, Infrastructure support for the Department of Epidemiology and Biostatistics at Imperial College London (UK) was provided by the NIHR Imperial Biomedical Research Centre (BRC)

Published
2021

195. Additional file 1 of Dietary intake of trans fatty acids and breast cancer risk in 9 European countries

Author

Matta, Michèle, Huybrechts, Inge, Biessy, Carine, Casagrande, Corinne, Yammine, Sahar, Fournier, Agnès, Olsen, Karina Standahl, Lukic, Marco, Gram, Inger Torhild, Ardanaz, Eva, Maria-José Sánchez, Dossus, Laure, Fortner, Renée T., Srour, Bernard, Jannasch, Franziska, Schulze, Matthias B., Amiano, Pilar, Agudo, Antonio, Colorado-Yohar, Sandra, J. Ramón Quirós, Tumino, Rosario, Panico, Salvatore, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Tjønneland, Anne, Olsen, Anja, Dahm, Christina C., Rosendahl, Ann H., Borgquist, Signe, Wennberg, Maria, Heath, Alicia K., Aune, Dagfinn, Schmidt, Julie, Weiderpass, Elisabete, Chajes, Veronique, Gunter, Marc J., and Murphy, Neil

Abstract

Additional file 1: Table S1. Population characteristics. Table S2. Spearman rank correlations between dietary intakes of trans fatty acids. Table S3. Food group sources of predominant ruminant and industrial trans fatty acids. Table S4. Associations between dietary intake of trans fatty acids and breast cancer risk according to oestrogen receptor status. Table S5. Associations between dietary intake of trans fatty acids and breast cancer risk according to progesterone receptor status. Table S6. Associations between dietary intake of trans fatty acids and breast cancer risk according to human epidermal growth factor receptor 2 status. Table S7. Associations between dietary intake of trans fatty acids and breast cancer risk according to body mass index group. Table S8. Associations between dietary intake of trans fatty acids and breast cancer risk according to menopausal status. Table S9. Associations between dietary intake of total trans industrial and ruminant fatty acids and breast cancer risk after adjustment for total energy using the residuals method. Table S10. Associations between dietary intake of total trans industrial and ruminant fatty acids and breast cancer risk after mutual adjustment. Table S11. Associations between dietary intake of total trans industrial and ruminant fatty acids and breast cancer risk after adjustment for dietary intakes of saturated fatty acid, monounsaturated fatty acid, and polyunsaturated fatty acid. Table S12. Associations between dietary intake of total trans fatty acids and breast cancer risk adjusted for the World Cancer Research Fund and Mediterranean diet scores. Table S13. P for trend values for the associations between dietary intakes of trans fatty acids and breast cancer risk using the continuous variable and quintile-median approaches. Figure 1. Associations between dietary intake of total trans industrial fatty acids and breast cancer risk by country. Figure 2. Associations between dietary intake of total trans ruminant fatty acids and breast cancer risk by country.

Published
2021
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196. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Author

Sofianopoulou, Eleni, Kaptoge, Stephen K, Afzal, Shoaib, Jiang, Tao, Gill, Dipender, Gundersen, Thomas E, Bolton, Thomas R, Allara, Elias, Arnold, Matthew G, Mason, Amy M, Chung, Ryan, Pennells, Lisa A M, Shi, Fanchao, Sun, Luanluan, Willeit, Peter, Forouhi, Nita G, Langenberg, Claudia, Sharp, Stephen J, Panico, Salvatore, Engström, Gunnar, Melander, Olle, Tong, Tammy Y N, Perez-Cornago, Aurora, Norberg, Margareta, Johansson, Ingegerd, Katzke, Verena, Srour, Bernard, José Sánchez, María, Redondo-Sánchez, Daniel, Olsen, Anja, Dahm, Christina C, Overvad, Kim, Brustad, Magritt, Skeie, Guri, Moreno-Iribas, Conchi, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Tsilidis, Konstantinos K, Heath, Alicia K, Agnoli, Claudia, Krogh, Vittorio, de Boer, Ian H, Kobylecki, Camilla Jannie, Çolak, Yunus, Zittermann, Armin, Sundström, Johan, Welsh, Paul, Weiderpass, Elisabete, Aglago, Elom K, Ferrari, Pietro, Sofianopoulou, Eleni, Kaptoge, Stephen K, Afzal, Shoaib, Jiang, Tao, Gill, Dipender, Gundersen, Thomas E, Bolton, Thomas R, Allara, Elias, Arnold, Matthew G, Mason, Amy M, Chung, Ryan, Pennells, Lisa A M, Shi, Fanchao, Sun, Luanluan, Willeit, Peter, Forouhi, Nita G, Langenberg, Claudia, Sharp, Stephen J, Panico, Salvatore, Engström, Gunnar, Melander, Olle, Tong, Tammy Y N, Perez-Cornago, Aurora, Norberg, Margareta, Johansson, Ingegerd, Katzke, Verena, Srour, Bernard, José Sánchez, María, Redondo-Sánchez, Daniel, Olsen, Anja, Dahm, Christina C, Overvad, Kim, Brustad, Magritt, Skeie, Guri, Moreno-Iribas, Conchi, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Tsilidis, Konstantinos K, Heath, Alicia K, Agnoli, Claudia, Krogh, Vittorio, de Boer, Ian H, Kobylecki, Camilla Jannie, Çolak, Yunus, Zittermann, Armin, Sundström, Johan, Welsh, Paul, Weiderpass, Elisabete, Aglago, Elom K, and Ferrari, Pietro

Published
2021
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197. Dietary Fatty Acids, Macronutrient Substitutions, Food Sources and Incidence of Coronary Heart Disease : Findings From the EPIC-CVD Case-Cohort Study Across Nine European Countries

Author

Steur, Marinka, Johnson, Laura, Sharp, Stephen J, Imamura, Fumiaki, Sluijs, Ivonne, Key, Timothy J, Wood, Angela, Chowdhury, Rajiv, Guevara, Marcela, Jakobsen, Marianne U, Johansson, Ingegerd, Koulman, Albert, Overvad, Kim, Sánchez, Maria-José, van der Schouw, Yvonne T, Trichopoulou, Antonia, Weiderpass, Elisabete, Wennberg, Maria, Zheng, Ju-Sheng, Boeing, Heiner, Boer, Jolanda M A, Boutron-Ruault, Marie-Christine, Ericson, Ulrika, Heath, Alicia K, Huybrechts, Inge, Imaz, Liher, Kaaks, Rudolf, Krogh, Vittorio, Kühn, Tilman, Kyrø, Cecilie, Masala, Giovanna, Melander, Olle, Moreno-Iribas, Conchi, Panico, Salvatore, Quirós, José R, Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Santiuste, Carmen, Skeie, Guri, Tjønneland, Anne, Tumino, Rosario, Verschuren, W M Monique, Zamora-Ros, Raul, Dahm, Christina C, Perez-Cornago, Aurora, Schulze, Matthias B, Tong, Tammy Y N, Riboli, Elio, Wareham, Nicholas J, Danesh, John, Butterworth, Adam S, Forouhi, Nita G, Steur, Marinka, Johnson, Laura, Sharp, Stephen J, Imamura, Fumiaki, Sluijs, Ivonne, Key, Timothy J, Wood, Angela, Chowdhury, Rajiv, Guevara, Marcela, Jakobsen, Marianne U, Johansson, Ingegerd, Koulman, Albert, Overvad, Kim, Sánchez, Maria-José, van der Schouw, Yvonne T, Trichopoulou, Antonia, Weiderpass, Elisabete, Wennberg, Maria, Zheng, Ju-Sheng, Boeing, Heiner, Boer, Jolanda M A, Boutron-Ruault, Marie-Christine, Ericson, Ulrika, Heath, Alicia K, Huybrechts, Inge, Imaz, Liher, Kaaks, Rudolf, Krogh, Vittorio, Kühn, Tilman, Kyrø, Cecilie, Masala, Giovanna, Melander, Olle, Moreno-Iribas, Conchi, Panico, Salvatore, Quirós, José R, Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Santiuste, Carmen, Skeie, Guri, Tjønneland, Anne, Tumino, Rosario, Verschuren, W M Monique, Zamora-Ros, Raul, Dahm, Christina C, Perez-Cornago, Aurora, Schulze, Matthias B, Tong, Tammy Y N, Riboli, Elio, Wareham, Nicholas J, Danesh, John, Butterworth, Adam S, and Forouhi, Nita G

Abstract

Background: There is controversy about associations between total dietary fatty acids, their classes (saturated fatty acids [SFAs], monounsaturated fatty acids, and polyunsaturated fatty acids), and risk of coronary heart disease (CHD). Specifically, the relevance of food sources of SFAs to CHD associations is uncertain. Methods and Results: We conducted a case-cohort study involving 10 529 incident CHD cases and a random subcohort of 16 730 adults selected from a cohort of 385 747 participants in 9 countries of the EPIC (European Prospective Investigation into Cancer and Nutrition) study. We estimated multivariable adjusted country-specific hazard ratios (HRs) and 95% CIs per 5% of energy intake from dietary fatty acids, with and without isocaloric macronutrient substitutions, using Prentice-weighted Cox regression models and pooled results using random-effects meta-analysis. We found no evidence for associations of the consumption of total or fatty acid classes with CHD, regardless of macronutrient substitutions. In analyses considering food sources, CHD incidence was lower per 1% higher energy intake of SFAs from yogurt (HR, 0.93 [95% CI, 0.88-0.99]), cheese (HR, 0.98 [95% CI, 0.96-1.00]), and fish (HR, 0.87 [95% CI, 0.75-1.00]), but higher for SFAs from red meat (HR, 1.07 [95% CI, 1.02-1.12]) and butter (HR, 1.02 [95% CI, 1.00-1.04]). Conclusions: This observational study found no strong associations of total fatty acids, SFAs, monounsaturated fatty acids, and polyunsaturated fatty acids, with incident CHD. By contrast, we found associations of SFAs with CHD in opposite directions dependent on the food source. These findings should be further confirmed, but support public health recommendations to consider food sources alongside the macronutrients they contain, and suggest the importance of the overall food matrix.

Published
2021
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198. Prediagnostic blood selenium status and mortality among patients with colorectal cancer in western european populations

Author

Baker, Jacqueline Roshelli, Umesh, Sushma, Jenab, Mazda, Schomburg, Lutz, Tjønneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Rothwell, Joseph A., Severi, Gianluca, Katzke, Verena, Johnson, Theron, Schulze, Matthias B., Masala, Giovanna, Agnoli, Claudia, Simeon, Vittorio, Tumino, Rosario, Bueno-De-mesquita, H. Bas, Gram, Inger Torhild, Skeie, Guri, Bonet, Catalina, Rodriguez-Barranco, Miguel, Houerta, José María, Gylling, Björn, Van Guelpen, Bethany, Perez-Cornago, Aurora, Aglago, Elom, Freisling, Heinz, Weiderpass, Elisabete, Cross, Amanda J., Heath, Alicia K., Hughes, David J., Fedirko, Veronika, Baker, Jacqueline Roshelli, Umesh, Sushma, Jenab, Mazda, Schomburg, Lutz, Tjønneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Rothwell, Joseph A., Severi, Gianluca, Katzke, Verena, Johnson, Theron, Schulze, Matthias B., Masala, Giovanna, Agnoli, Claudia, Simeon, Vittorio, Tumino, Rosario, Bueno-De-mesquita, H. Bas, Gram, Inger Torhild, Skeie, Guri, Bonet, Catalina, Rodriguez-Barranco, Miguel, Houerta, José María, Gylling, Björn, Van Guelpen, Bethany, Perez-Cornago, Aurora, Aglago, Elom, Freisling, Heinz, Weiderpass, Elisabete, Cross, Amanda J., Heath, Alicia K., Hughes, David J., and Fedirko, Veronika

Abstract

A higher selenium (Se) status has been shown to be associated with lower risk for colorectal cancer (CRC), but the importance of Se in survival after CRC diagnosis is not well studied. The associations of prediagnostic circulating Se status (as indicated by serum Se and selenoprotein P (SELENOP) measurements) with overall and CRC-specific mortality were estimated using multi-variable Cox proportional hazards regression among 995 CRC cases (515 deaths, 396 from CRC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Se and SELENOP serum concentrations were measured on average 46 months before CRC diagnosis. Median follow-up time was 113 months. Participants with Se concentrations in the highest quintile (≥100 µg/L) had a multivariable-adjusted hazard ratio (HR) of 0.73 (95% CI: 0.52–1.02; Ptrend = 0.06) for CRC-specific mortality and 0.77 (95% CI: 0.57–1.03; Ptrend = 0.04) for overall mortality, compared with the lowest quintile (≤67.5 µg/L). Similarly, participants with SELENOP concentrations in the highest (≥5.07 mg/L) compared with the lowest quintile (≤3.53 mg/L) had HRs of 0.89 (95% CI: 0.64–1.24; Ptrend = 0.39) for CRC-specific mortality and 0.83 (95% CI: 0.62–1.11; Ptrend = 0.17) for overall mortal-ity. Higher prediagnostic exposure to Se within an optimal concentration (100–150 µg/L) might be associated with improved survival among CRC patients, although our results were not statistically significant and additional studies are needed to confirm this potential association. Our findings may stimulate further research on selenium’s role in survival among CRC patients especially among those residing in geographic regions with suboptimal Se availability.

Published
2021
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199. A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author

Clasen, Joanna L., Heath, Alicia K., Van Puyvelde, Heleen, Huybrechts, Inge, Park, Jin Young, Ferrari, Pietro, Johansson, Mattias, Scelo, Ghislaine, Ulvik, Arve, Midttun, Øivind, Ueland, Per Magne, Dahm, Christina C., Halkjær, Jytte, Olsen, Anja, Johnson, Theron, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Segrado, Francesco, de Magistris, Maria Santucci, Sacerdote, Carlotta, Ocké, Marga C., Luján-Barroso, Leila, Ching-López, Ana, Huerta, José María, Ardanaz, Eva, Amiano, Pilar, Ericson, Ulrika, Manjer, Jonas, Gylling, Björn, Johansson, Ingegerd, Schmidt, Julie, Weiderpass, Elisabete, Riboli, Elio, Cross, Amanda J., Muller, David C., Clasen, Joanna L., Heath, Alicia K., Van Puyvelde, Heleen, Huybrechts, Inge, Park, Jin Young, Ferrari, Pietro, Johansson, Mattias, Scelo, Ghislaine, Ulvik, Arve, Midttun, Øivind, Ueland, Per Magne, Dahm, Christina C., Halkjær, Jytte, Olsen, Anja, Johnson, Theron, Katzke, Verena, Schulze, Matthias B., Masala, Giovanna, Segrado, Francesco, de Magistris, Maria Santucci, Sacerdote, Carlotta, Ocké, Marga C., Luján-Barroso, Leila, Ching-López, Ana, Huerta, José María, Ardanaz, Eva, Amiano, Pilar, Ericson, Ulrika, Manjer, Jonas, Gylling, Björn, Johansson, Ingegerd, Schmidt, Julie, Weiderpass, Elisabete, Riboli, Elio, Cross, Amanda J., and Muller, David C.

Abstract

BACKGROUND: Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5'-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health. OBJECTIVES: We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics. MEDTHODS: Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP. RESULTS: In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers. CONCLUSIONS: We found that 5 different markers, capturing different aspects of vitamin B6-related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.

Published
2021
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200. Dietary methyl-group donor intake and breast cancer risk in the european prospective investigation into cancer and nutrition (EPIC)

Author

Van Puyvelde, Heleen, Papadimitriou, Nikos, Clasen, Joanna, Muller, David, Biessy, Carine, Ferrari, Pietro, Halkjær, Jytte, Overvad, Kim, Tjønneland, Anne, Fortner, Renée T., Katzke, Verena, Schulze, Matthias B., Chiodini, Paolo, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Tumino, Rosario, Bakker, Marije F., Agudo, Antonio, Ardanaz, Eva, López, María Dolores Chirlaque, Sánchez, Maria-Jose, Ericson, Ulrika, Gylling, Björn, Karlsson, Therese, Manjer, Jonas, Schmidt, Julie A., Nicolas, Geneviève, Casagrande, Corinne, Weiderpass, Elisabete, Heath, Alicia K., Godderis, Lode, Van Herck, Koen, De Bacquer, Dirk, Gunter, Marc J., Huybrechts, Inge, Van Puyvelde, Heleen, Papadimitriou, Nikos, Clasen, Joanna, Muller, David, Biessy, Carine, Ferrari, Pietro, Halkjær, Jytte, Overvad, Kim, Tjønneland, Anne, Fortner, Renée T., Katzke, Verena, Schulze, Matthias B., Chiodini, Paolo, Masala, Giovanna, Pala, Valeria, Sacerdote, Carlotta, Tumino, Rosario, Bakker, Marije F., Agudo, Antonio, Ardanaz, Eva, López, María Dolores Chirlaque, Sánchez, Maria-Jose, Ericson, Ulrika, Gylling, Björn, Karlsson, Therese, Manjer, Jonas, Schmidt, Julie A., Nicolas, Geneviève, Casagrande, Corinne, Weiderpass, Elisabete, Heath, Alicia K., Godderis, Lode, Van Herck, Koen, De Bacquer, Dirk, Gunter, Marc J., and Huybrechts, Inge

Abstract

(1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre-and postmenopausal women were followed between enrolment in 1992–2000 and December 2013–December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 µg/day compared to a reference intake of 205 µg/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.

Published
2021
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