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153. Rentenanspruch

Author

Stamatiadis-Smidt, Hilke, zur Hausen, Harald, Stamatiadis-Smidt, Hilke, editor, and zur Hausen, Harald, editor

Published
1998
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158. Mechanism of phototaxis in marine zooplankton

Author

Jekely, Gaspar, Colombelli, Julien, Hausen, Harald, Guy, Keren, Stelzer, Ernst, Nedelec, Francois, and Arendt, Detlev

Subjects
Optical properties, Research, Zooplankton -- Optical properties -- Research, Phototaxis -- Research -- Optical properties, Larvae -- Optical properties -- Research, Photobiology -- Research -- Optical properties
Abstract

The simplest animal eyes are eyespots composed of two cells only: a photoreceptor and a shading pigment cell. They resemble Darwin's 'proto-eyes', considered to be the first eyes to appear [...]

Published
2008

161. Analysis of chronic inflammatory lesions of the colon for BMMF Rep antigen expression and CD68 macrophage interactions

Author

Bund, Timo; https://orcid.org/0000-0002-3304-4494, Nikitina, Ekaterina; https://orcid.org/0000-0003-2234-5889, Chakraborty, Deblina, Ernst, Claudia, Gunst, Karin, Boneva, Boyana; https://orcid.org/0000-0003-1727-8888, Tessmer, Claudia, Volk, Nadine, Brobeil, Alexander, Weber, Achim, Heikenwalder, Mathias, Zur Hausen, Harald; https://orcid.org/0000-0003-1103-0347, de Villiers, Ethel-Michele; https://orcid.org/0000-0003-4357-0567, Bund, Timo; https://orcid.org/0000-0002-3304-4494, Nikitina, Ekaterina; https://orcid.org/0000-0003-2234-5889, Chakraborty, Deblina, Ernst, Claudia, Gunst, Karin, Boneva, Boyana; https://orcid.org/0000-0003-1727-8888, Tessmer, Claudia, Volk, Nadine, Brobeil, Alexander, Weber, Achim, Heikenwalder, Mathias, Zur Hausen, Harald; https://orcid.org/0000-0003-1103-0347, and de Villiers, Ethel-Michele; https://orcid.org/0000-0003-4357-0567

Abstract

Consumption of Eurasian bovine meat and milk has been associated with cancer development, in particular with colorectal cancer (CRC). In addition, zoonotic infectious agents from bovine products were proposed to cause colon cancer (zur Hausen et al., 2009). Bovine meat and milk factors (BMMF) are small episomal DNA molecules frequently isolated from bovine sera and milk products, and recently, also from colon cancer (de Villiers et al., 2019). BMMF are bioactive in human cells and were proposed to induce chronic inflammation in precancerous tissue leading to increased radical formation: for example, reactive oxygen and reactive nitrogen species and elevated levels of DNA mutations in replicating cells, such as cancer progenitor cells (zur Hausen et al., 2018). Mouse monoclonal antibodies against the replication (Rep) protein of H1MSB.1 (BMMF1) were used to analyze BMMF presence in different cohorts of CRC peritumor and tumor tissues and cancer-free individuals by immunohistochemistry and Western blot. BMMF DNA was isolated by laser microdissection from immunohistochemistry-positive tissue regions. We found BMMF Rep protein present specifically in close vicinity of CD68$^{+}$ macrophages in the interstitial lamina propria adjacent to CRC tissues, suggesting the presence of local chronic inflammation. BMMF1 (modified H1MSB.1) DNA was isolated from the same tissue regions. Rep and CD68$^{+}$ detection increased significantly in peritumor cancer tissues when compared to tissues of cancer-free individuals. This strengthens previous postulations that BMMF function as indirect carcinogens by inducing chronic inflammation and DNA damage in replicating cells, which represent progress to progenitor cells for adenoma (polyps) formation and cancer.

Published
2021

162. Conserved Sensory-Neurosecretory Cell Types in Annelid and Fish Forebrain: Insights into Hypothalamus Evolution

Author

Tessmar-Raible, Kristin, Raible, Florian, Christodoulou, Foteini, Guy, Keren, Rembold, Martina, Hausen, Harald, and Arendt, Detlev

Subjects
Evolution, Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2007.04.041 Byline: Kristin Tessmar-Raible (1), Florian Raible (1)(2), Foteini Christodoulou (1), Keren Guy (1), Martina Rembold (1), Harald Hausen (3), Detlev Arendt (1) Keywords: DEVBIO; EVO_ECOL; RNA Abstract: Neurosecretory control centers form part of the forebrain in many animal phyla, including vertebrates, insects, and annelids. The evolutionary origin of these centers is largely unknown. To identify conserved, and thus phylogenetically ancient, components of neurosecretory brain centers, we characterize and compare neurons that express the prohormone vasotocin (vasopressin/oxytocin)-neurophysin in the developing forebrain of the annelid Platynereis dumerilii and of the zebrafish. These neurons express the same tissue-restricted microRNA, miR-7, and conserved, cell-type-specific combinations of transcription factors (nk2.1, rx, and otp) that specify their identity, as evidenced by the specific requirement of zebrafish rx3 for vasotocin-neurophysin expression. MiR-7 also labels another shared population of neurons containing RFamides. Since the vasotocinergic and RFamidergic neurons appear to be directly sensory in annelid and fish, we propose that cell types with dual sensory-neurosecretory properties were the starting point for the evolution of neurosecretory brain centers in Bilateria. Author Affiliation: (1) Developmental Biology Unit, European Molecular Biology Laboratory, MeyerhofstraAe 1, D-69012 Heidelberg, Germany (2) Computational Biology Unit, European Molecular Biology Laboratory, MeyerhofstraAe 1, D-69012 Heidelberg, Germany (3) Institut fur Biologie, FU Berlin, Konigin-Luisen-StraAe 1-3, D-14195 Berlin, Germany Article History: Received 3 August 2006; Revised 12 January 2007; Accepted 26 April 2007 Article Note: (miscellaneous) Published: June 28, 2007

Published
2007

180. AIDS und Krebs

Author

Stamatiadis-Smidt, Hilke, zur Hausen, Harald, Stamatiadis-Smidt, Hilke, editor, and zur Hausen, Harald, editor

Published
1998
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184. Additional file 19 of The development of early pioneer neurons in the annelid Malacoceros fuliginosus

Author

Kumar, Suman, Sharat Chandra Tumu, Helm, Conrad, and Hausen, Harald

Abstract

Additional file 19 Evolution of Prox1 genes. Adobe Acrobat file (.pdf). Unrooted maximum-likelihood tree (IQ-TREE, model LG + R4 chosen by Modelfinder). Branches with approximate Bayes test ≥0.98 are labelled. Sequences of M. fuliginosus are highlighted in red. Genes we found being expressed in the analyzed stages are marked by arrows.

Published
2020
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185. Additional file 23 of The development of early pioneer neurons in the annelid Malacoceros fuliginosus

Author

Kumar, Suman, Sharat Chandra Tumu, Helm, Conrad, and Hausen, Harald

Abstract

Additional file 23 Evolution of SoxB genes. Adobe Acrobat file (.pdf). The tree is based on a subset of the analysis shown in Fig. S6 with a SoxB-specific sequence and longer alignment. Maximum-likelihood tree (IQ-TREE, model JTT + R5 chosen by Modelfinder). Branches with approximate Bayes test ≥0.98 are labelled. Sequences of M. fuliginosus are highlighted in red. Genes we found being expressed in the analyzed stages are marked by arrows.

Published
2020
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195. Human papillomaviruses

Author

Hausen, Harald zur and Villiers, Ethel-Michele de

Subjects
Evaluation, Causes of, Papillomavirus -- Evaluation, Cervical cancer -- Causes of, Papillomaviruses -- Evaluation
Abstract

Introduction Papillomaviruses were identified as vital particles in 1949 (108). Although the infectious nature of animal and human warts was well established in the 1890s, no other group of viruses [...]

Published
1994

197. Alkohol

Author

Stamatiadis-Smidt, Hilke, primary and zur Hausen, Harald, additional

Published
1998
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