2,347 results on '"Hattersley, Andrew T."'
Search Results
152. A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
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The Wellcome Trust Case Control Consortium, Frayling, Timothy M., Timpson, Nicholas J., Weedon, Michael N., Zeggini, Eleftheria, Freathy, Rachel M., Lindgren, Cecilia M., Perry, John R. B., Elliott, Katherine S., Lango, Hana, Rayner, Nigel W., Shields, Beverley, Harries, Lorna W., Barrett, Jeffrey C., Ellard, Sian, Groves, Christopher J., Knight, Bridget, Patch, Ann-Marie, Ness, Andrew R., Ebrahim, Shah, Lawlor, Debbie A., Ring, Susan M., Ben-Shlomo, Yoav, Jarvelin, Marjo-Riitta, Sovio, Ulla, Bennett, Amanda J., Melzer, David, Ferrucci, Luigi, Loos, Ruth J. F., Barroso, Inês, Wareham, Nicholas J., Karpe, Fredrik, Owen, Katharine R., Cardon, Lon R., Walker, Mark, Hitman, Graham A., Palmer, Colin N. A., Doney, Alex S. F., Morris, Andrew D., Smith, George Davey, Hattersley, Andrew T., and McCarthy, Mark I.
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- 2007
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153. Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight
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Thompson, William D, primary, Beaumont, Robin N, additional, Kuang, Alan, additional, Warrington, Nicole M, additional, Ji, Yingjie, additional, Tyrrell, Jessica, additional, Wood, Andrew R, additional, Scholtens, Denise M, additional, Knight, Bridget A, additional, Evans, David M, additional, Lowe Jr, William L, additional, Santorelli, Gillian, additional, Azad, Raq, additional, Mason, Dan, additional, Hattersley, Andrew T, additional, Frayling, Timothy M, additional, Yaghootkar, Hanieh, additional, Borges, Maria Carolina, additional, Lawlor, Deborah A, additional, and Freathy, Rachel M, additional
- Published
- 2021
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154. Systematic genetic testing for recessively inherited monogenic diabetes: a cross-sectional study in paediatric diabetes clinics
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Patel, Kashyap A., primary, Ozbek, Mehmet N., additional, Yildiz, Melek, additional, Guran, Tulay, additional, Kocyigit, Cemil, additional, Acar, Sezer, additional, Siklar, Zeynep, additional, Atar, Muge, additional, Colclough, Kevin, additional, Houghton, Jayne, additional, Johnson, Matthew B., additional, Ellard, Sian, additional, Flanagan, Sarah E., additional, Cizmecioglu, Filiz, additional, Berberoglu, Merih, additional, Demir, Korcan, additional, Catli, Gonul, additional, Bas, Serpil, additional, Akcay, Teoman, additional, Demirbilek, Huseyin, additional, Weedon, Michael N., additional, and Hattersley, Andrew T., additional
- Published
- 2021
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155. Gene discovery in neonatal diabetes to uncover the mechanisms regulating human pancreas development
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De, Franco Elisa, primary, Wakeling, Matthew, additional, Owens, Nick, additional, Johnson, Matthew, additional, Flanagan, Sarah, additional, and Hattersley, Andrew T, additional
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- 2021
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156. Association of birthweight and penetrance of diabetes in individuals with HNF4A-MODY: a cohort study
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Locke, Jonathan M., primary, Dusatkova, Petra, additional, Colclough, Kevin, additional, Hughes, Alice E., additional, Dennis, John M., additional, Shields, Beverley, additional, Flanagan, Sarah E., additional, Shepherd, Maggie H., additional, Dempster, Emma L., additional, Hattersley, Andrew T., additional, Weedon, Michael N., additional, Pruhova, Stepanka, additional, and Patel, Kashyap A., additional
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- 2021
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157. The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells
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Oram, Richard A., Jones, Angus G., Besser, Rachel E. J., Knight, Bridget A., Shields, Beverley M., Brown, Richard J., Hattersley, Andrew T., and McDonald, Timothy J.
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- 2014
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158. Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight
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Tyrrell, Jessica, Richmond, Rebecca C., Palmer, Tom M., Feenstra, Bjarke, Rangarajan, Janani, Metrustry, Sarah, Cavadino, Alana, Paternoster, Lavinia, Armstrong, Loren L., De Silva, N. Maneka G., Wood, Andrew R., Horikoshi, Momoko, Geller, Frank, Myhre, Ronny, Bradfield, Jonathan P., Kreiner-Møller, Eskil, Huikari, Ville, Painter, Jodie N., Hottenga, Jouke-Jan, Allard, Catherine, Berry, Diane J., Bouchard, Luigi, Das, Shikta, Evans, David M., Hakonarson, Hakon, Hayes, M. Geoffrey, Heikkinen, Jani, Hofman, Albert, Knight, Bridget, Lind, Penelope A., McCarthy, Mark I., McMahon, George, Medland, Sarah E., Melbye, Mads, Morris, Andrew P., Nodzenski, Michael, Reichetzeder, Christoph, Ring, Susan M., Sebert, Sylvain, Sengpiel, Verena, Sørensen, Thorkild I. A., Willemsen, Gonneke, de Geus, Eco J. C., Martin, Nicholas G., Spector, Tim D., Power, Christine, Järvelin, Marjo-Riitta, Bisgaard, Hans, Grant, Struan F. A., Nohr, Ellen A., Jaddoe, Vincent W., Jacobsson, Bo, Murray, Jeffrey C., Hocher, Berthold, Hattersley, Andrew T., Scholtens, Denise M., Davey Smith, George, Hivert, Marie-France, Felix, Janine F., Hyppönen, Elina, Lowe, William L., Jr, Frayling, Timothy M., Lawlor, Debbie A., and Freathy, Rachel M.
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- 2016
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159. Routine Islet Autoantibody Testing in Clinically Diagnosed Adult-Onset Type 1 Diabetes Can Help Identify Misclassification and the Possibility of Successful Insulin Cessation.
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Eason, Russell J., Thomas, Nicholas J., Hill, Anita V., Knight, Bridget A., Carr, Alice, Hattersley, Andrew T., McDonald, Timothy J., Shields, Beverley M., Jones, Angus G., SimonGodwinRamosAngeloNorrisAndreaTanKaiNarendranParthRamtoolaShenazAliAmarBanerjeeMoulinathBrooksAugustinChakeraAliJohnsonAndrewTatovicDanijelaBallavChitrabhanuDayanColinNairSunilGameFrancesJonesAngusBeamesSusanRaymanGerrySnellMarieButlerSusieBeckSarahBe, Simon, Godwin, Ramos, Angelo, Norris, Andrea, Tan, Kai, Narendran, Parth, Ramtoola, Shenaz, Ali, Amar, Banerjee, Moulinath, Brooks, Augustin, and Chakera, Ali
- Abstract
OBJECTIVE: Recent joint American Diabetes Association and European Association for the Study of Diabetes guidelines recommend routine islet autoantibody testing in all adults newly diagnosed with type 1 diabetes. We aimed to assess the impact of routine islet autoantibody testing in this population. RESEARCH DESIGN AND METHODS: We prospectively assessed the relationship between islet autoantibody status (GADA, IA-2A, and ZNT8A), clinical and genetic characteristics, and progression (annual change in urine C-peptide–to–creatinine ratio [UCPCR]) in 722 adults (≥18 years old at diagnosis) with clinically diagnosed type 1 diabetes and diabetes duration <12 months. We also evaluated changes in treatment and glycemia over 2 years after informing participants and their clinicians of autoantibody results. RESULTS: Of 722 participants diagnosed with type 1 diabetes, 24.8% (179) were autoantibody negative. This group had genetic and C-peptide characteristics suggestive of a high prevalence of nonautoimmune diabetes: lower mean type 1 diabetes genetic risk score (islet autoantibody negative vs. positive: 10.85 vs. 13.09 [P < 0.001] [type 2 diabetes 10.12]) and lower annual change in C-peptide (UCPCR), −24% vs. −43% (P < 0.001). After median 24 months of follow-up, treatment change occurred in 36.6% (60 of 164) of autoantibody-negative participants: 22.6% (37 of 164) discontinued insulin, with HbA
1c similar to that of participants continuing insulin (57.5 vs. 60.8 mmol/mol [7.4 vs. 7.7%], P = 0.4), and 14.0% (23 of 164) added adjuvant agents to insulin. CONCLUSIONS: In adult-onset clinically diagnosed type 1 diabetes, negative islet autoantibodies should prompt careful consideration of other diabetes subtypes. When routinely measured, negative antibodies are associated with successful insulin cessation. These findings support recent recommendations for routine islet autoantibody assessment in adult-onset type 1 diabetes. [ABSTRACT FROM AUTHOR]- Published
- 2022
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160. Monogenic disorders of the β cell
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Chakera, Ali J., primary and Hattersley, Andrew T., additional
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- 2015
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161. Cystatin C is not a good candidate biomarker for HNF1A-MODY
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Nowak, Natalia, Szopa, Magdalena, Thanabalasingham, Gaya, McDonald, Tim J., Colclough, Kevin, Skupien, Jan, James, Timothy J., Kiec-Wilk, Beata, Kozek, Elzbieta, Mlynarski, Wojciech, Hattersley, Andrew T., Owen, Katharine R., and Malecki, Maciej T.
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- 2013
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162. A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly
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Abdulkarim, Baroj, Nicolino, Marc, Igoillo-Esteve, Mariana, Daures, Mathilde, Romero, Sophie, Philippi, Anne, Senée, Valérie, Lopes, Miguel, Cunha, Daniel A., Harding, Heather P., Derbois, Céline, Bendelac, Nathalie, Hattersley, Andrew T., Eizirik, Décio L., Ron, David, Cnop, Miriam, and Julier, Cécile
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- 2015
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163. Reappearance of C-Peptide During the Third Trimester of Pregnancy in Type 1 Diabetes: Pancreatic Regeneration or Fetal Hyperinsulinism?
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Meek, Claire L, Oram, Richard A, McDonald, Timothy J, Feig, Denice S, Hattersley, Andrew T, Murphy, Helen R, CONCEPTT Collaborative Group, Meek, Claire L [0000-0002-4176-8329], and Apollo - University of Cambridge Repository
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Blood Glucose ,Diabetes Mellitus, Type 1 ,C-Peptide ,Pregnancy ,Blood Glucose Self-Monitoring ,Hyperinsulinism ,Pregnancy Trimester, Third ,Pregnancy Outcome ,Humans ,Regeneration ,Female - Abstract
Objective: We assessed longitudinal patterns of maternal C-peptide concentration to examine the hypothesis of beta-cell regeneration in type 1 diabetes pregnancy. Research Design & Methods: C-peptide was measured on maternal serum samples from 127 participants (12, 24, 34 weeks) and cord blood during the continuous glucose monitoring in type 1 diabetes pregnancy trial (CONCEPTT). C-peptide was measured using a highly sensitive direct and solid-phase competitive electrochemiluminescent immunoassay. Results: Three discrete patterns of maternal C-peptide trajectory were identified: Pattern 1 undetectable throughout pregnancy, n=74 (58%, maternal C-peptide Conclusion: First maternal C-peptide appearance at 34 weeks was associated with mid-trimester hyperglycemia, elevated cord blood C-peptide and high rates of neonatal complications. This suggests transfer of C-peptide from fetal to maternal serum and is inconsistent with pregnancy-related beta-cell regeneration.
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- 2021
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164. Evaluation of evidence for pathogenicity demonstrates thatBLK, KLF11andPAX4should not be included in diagnostic testing for MODY
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Laver, Thomas W, primary, Wakeling, Matthew N, additional, Knox, Olivia, additional, Colclough, Kevin, additional, Wright, Caroline F, additional, Ellard, Sian, additional, Hattersley, Andrew T, additional, Weedon, Michael N, additional, and Patel, Kashyap A, additional
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- 2021
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165. Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study
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Atabaki-Pasdar, Naeimeh, primary, Pomares-Millan, Hugo, additional, Koivula, Robert W, additional, Tura, Andrea, additional, Brown, Andrew, additional, Viñuela, Ana, additional, Agudelo, Leandro, additional, Coral, Daniel, additional, van Oort, Sabine, additional, Allin, Kristine, additional, Chabanova, Elizaveta, additional, Cederberg, Henna, additional, De Masi, Federico, additional, Elders, Petra, additional, Tajes, Juan Fernandez, additional, Forgie, Ian M, additional, Hansen, Tue H, additional, Heggie, Alison, additional, Jones, Angus, additional, Kokkola, Tarja, additional, Mahajan, Anubha, additional, McDonald, Timothy J, additional, McEvoy, Donna, additional, Tsirigos, Konstantinos, additional, Teare, Harriet, additional, Vangipurapu, Jagadish, additional, Vestergaard, Henrik, additional, Adamski, Jerzy, additional, Beulens, Joline WJ, additional, Brunak, Søren, additional, Dermitzakis, Emmanouil, additional, Hansen, Torben, additional, Hattersley, Andrew T, additional, Laakso, Markku, additional, Pedersen, Oluf, additional, Ridderstråle, Martin, additional, Ruetten, Hartmut, additional, Rutters, Femke, additional, Schwenk, Jochen M, additional, Walker, Mark, additional, Giordano, Giuseppe N, additional, Ohlsson, Mattias, additional, Gupta, Ramneek, additional, Mari, Andrea, additional, McCarthy, Mark I, additional, Thomas, E Louise, additional, Bell, Jimmy D, additional, Pavo, Imre, additional, Pearson, Ewan R, additional, and Franks, Paul W, additional
- Published
- 2021
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166. HbA1c performs well in monitoring glucose control even in populations with high prevalence of medical conditions that may alter its reliability: the OPTIMAL observational multicenter study
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Niwaha, Anxious J, primary, Rodgers, Lauren R, additional, Greiner, Rosamund, additional, Balungi, Priscilla A, additional, Mwebaze, Raymond, additional, McDonald, Timothy J, additional, Hattersley, Andrew T, additional, Shields, Beverley M, additional, Nyirenda, Moffat J, additional, and Jones, Angus G, additional
- Published
- 2021
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167. The penetrance of age-related monogenic disease depends on ascertainment context
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Mirshahi, Uyenlinh L, primary, Colclough, Kevin, additional, Wright, Caroline F, additional, Wood, Andrew R, additional, Beaumont, Robin N, additional, Tyrrell, Jessica, additional, Laver, Thomas W, additional, Stahl, Richard, additional, Golden, Alicia, additional, Goehringer, Jessica M, additional, Frayling, Timothy F, additional, Hattersley, Andrew T, additional, Carey, David J, additional, Weedon, Michael N, additional, and Patel, Kashyap A, additional
- Published
- 2021
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168. Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children
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Bonifacio, Ezio, Beyerlein, Andreas, Hippich, Markus, Winkler, Christiane, Vehik, Kendra, Weedon, Michael N., Laimighofer, Michael, Hattersley, Andrew T., Krumsiek, Jan, Frohnert, Brigitte I., Steck, Andrea K., Hagopian, William A., Krischer, Jeffrey P., Lernmark, Åke, Rewers, Marian J., She, Jin-Xiong, Toppari, Jorma, Akolkar, Beena, Oram, Richard A., Rich, Stephen S., and Ziegler, Anette-G.
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Pancreatic beta cells -- Genetic aspects -- Health aspects ,Genotypes -- Identification and classification ,Autoantibodies -- Genetic aspects -- Health aspects ,Type 1 diabetes -- Genetic aspects -- Risk factors ,Biological sciences - Abstract
Background Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention of type 1 diabetes will require early intervention in genetically at-risk infants. The objective of this study was to determine to what extent genetic scores (two previous genetic scores and a merged genetic score) can improve the prediction of type 1 diabetes. Methods and findings The Environmental Determinants of Diabetes in the Young (TEDDY) study followed genetically at-risk children at 3- to 6-monthly intervals from birth for the development of islet autoantibodies and type 1 diabetes. Infants were enrolled between 1 September 2004 and 28 February 2010 and monitored until 31 May 2016. The risk (positive predictive value) for developing multiple islet autoantibodies (pre-symptomatic type 1 diabetes) and type 1 diabetes was determined in 4,543 children who had no first-degree relatives with type 1 diabetes and either a heterozygous HLA DR3 and DR4-DQ8 risk genotype or a homozygous DR4-DQ8 genotype, and in 3,498 of these children in whom genetic scores were calculated from 41 single nucleotide polymorphisms. In the children with the HLA risk genotypes, risk for developing multiple islet autoantibodies was 5.8% (95% CI 5.0%-6.6%) by age 6 years, and risk for diabetes by age 10 years was 3.7% (95% CI 3.0%-4.4%). Risk for developing multiple islet autoantibodies was 11.0% (95% CI 8.7%-13.3%) in children with a merged genetic score of >14.4 (upper quartile; n = 907) compared to 4.1% (95% CI 3.3%-4.9%, P 14.4 compared with 2.7% (95% CI 1.9%-3.6%) in children with a score of [less than or equal to]14.4 (P 14.4. Scores were higher in European versus US children (P = 0.003). In children with a merged score of >14.4, risk for multiple islet autoantibodies was similar and consistently >10% in Europe and in the US; risk was greater in males than in females (P = 0.01). Limitations of the study include that the genetic scores were originally developed from case-control studies of clinical diabetes in individuals of mainly European decent. It is, therefore, possible that it may not be suitable to all populations. Conclusions A type 1 diabetes genetic score identified infants without family history of type 1 diabetes who had a greater than 10% risk for pre-symptomatic type 1 diabetes, and a nearly 2-fold higher risk than children identified by high-risk HLA genotypes alone. This finding extends the possibilities for enrolling children into type 1 diabetes primary prevention trials., Author(s): Ezio Bonifacio 1, Andreas Beyerlein 2,3,4, Markus Hippich 2,3,4, Christiane Winkler 2,3,4, Kendra Vehik 5, Michael N. Weedon 6, Michael Laimighofer 7, Andrew T. Hattersley 6, Jan Krumsiek 7, [...]
- Published
- 2018
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169. Type 2 Diabetes, SGLT2 Inhibitors, and Glucose Secretion
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Hattersley, Andrew T. and Thorens, Bernard
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- 2015
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170. Recognition and Management of Individuals With Hyperglycemia Because of a Heterozygous Glucokinase Mutation
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Chakera, Ali J., Steele, Anna M., Gloyn, Anna L., Shepherd, Maggie H., Shields, Beverley, Ellard, Sian, and Hattersley, Andrew T.
- Published
- 2015
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171. Association Analysis of 29,956 Individuals Confirms That a Low-Frequency Variant at CCND2 Halves the Risk of Type 2 Diabetes by Enhancing Insulin Secretion
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Yaghootkar, Hanieh, Stancáková, Alena, Freathy, Rachel M., Vangipurapu, Jagadish, Weedon, Michael N., Xie, Weijia, Wood, Andrew R., Ferrannini, Ele, Mari, Andrea, Ring, Susan M., Lawlor, Debbie A., Davey Smith, George, Jørgensen, Torben, Hansen, Torben, Pedersen, Oluf, Steinthorsdottir, Valgerdur, Gubjartsson, Daniel F., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Stefansson, Kari, Hattersley, Andrew T., Walker, Mark, Morris, Andrew D., McCarthy, Mark I., Palmer, Colin N.A., Laakso, Markku, and Frayling, Timothy M.
- Published
- 2015
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172. Genetic studies of body mass index yield new insights for obesity biology
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Locke, Adam E., Kahali, Bratati, Berndt, Sonja I., Justice, Anne E., Pers, Tune H., Day, Felix R., Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L., Yang, Jian, Croteau-Chonka, Damien C., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltán, Luan, Jianʼan, Mägi, Reedik, Randall, Joshua C., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Faul, Jessica D., Smith, Jennifer A., Hua Zhao, Jing, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Åsa K., Karjalainen, Juha, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bolton, Jennifer L., Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Deng, Guohong, Ehret, Georg B., Feenstra, Bjarke, Feitosa, Mary F., Fischer, Krista, Goel, Anuj, Gong, Jian, Jackson, Anne U., Kanoni, Stavroula, Kleber, Marcus E., Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Medland, Sarah E., Nalls, Michael A., Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Shungin, Dmitry, Stančáková, Alena, Strawbridge, Rona J., Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W., van Setten, Jessica, Van Vliet-Ostaptchouk, Jana V., Wang, Zhaoming, Yengo, Loïc, Zhang, Weihua, Isaacs, Aaron, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Attwood, Antony P., Bandinelli, Stefania, Barrett, Amy, Bas, Isabelita N., Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blagieva, Roza, Blüher, Matthias, Böhringer, Stefan, Bonnycastle, Lori L., Böttcher, Yvonne, Boyd, Heather A., Bruinenberg, Marcel, Caspersen, Ida H., Ida Chen, Yii-Der, Clarke, Robert, Warwick Daw, E., de Craen, Anton J. M., Delgado, Graciela, Dimitriou, Maria, Doney, Alex S. F., Eklund, Niina, Estrada, Karol, Eury, Elodie, Folkersen, Lasse, Fraser, Ross M., Garcia, Melissa E., Geller, Frank, Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Goodall, Alison H., Gordon, Scott D., Gorski, Mathias, Grabe, Hans-Jörgen, Grallert, Harald, Grammer, Tanja B., Gräler, Jürgen, Grönberg, Henrik, Groves, Christopher J., Gusto, Gaëlle, Haessler, Jeffrey, Hall, Per, Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heard-Costa, Nancy L., Helmer, Quinta, Hengstenberg, Christian, Holmen, Oddgeir, Hottenga, Jouke-Jan, James, Alan L., Jeff, Janina M., Johansson, Åsa, Jolley, Jennifer, Juliusdottir, Thorhildur, Kinnunen, Leena, Koenig, Wolfgang, Koskenvuo, Markku, Kratzer, Wolfgang, Laitinen, Jaana, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Sin Lo, Ken, Lobbens, Stéphane, Lorbeer, Roberto, Lu, Yingchang, Mach, François, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., McLachlan, Stela, Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Moayyeri, Alireza, Monda, Keri L., Morken, Mario A., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Musk, Arthur W., Nagaraja, Ramaiah, Nöthen, Markus M., Nolte, Ilja M., Pilz, Stefan, Rayner, Nigel W., Renstrom, Frida, Rettig, Rainer, Ried, Janina S., Ripke, Stephan, Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Schumacher, Fredrick R., Scott, William R., Seufferlein, Thomas, Shi, Jianxin, Vernon Smith, Albert, Smolonska, Joanna, Stanton, Alice V., Steinthorsdottir, Valgerdur, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann-Christine, Tan, Sian-Tsung, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tyrer, Jonathan P., Uh, Hae-Won, Vandenput, Liesbeth, Verhulst, Frank C., Vermeulen, Sita H., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Warren, Helen R., Waterworth, Dawn, Weedon, Michael N., Wilkens, Lynne R., Willenborg, Christina, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Wright, Alan F., Zhang, Qunyuan, Brennan, Eoin P., Choi, Murim, Dastani, Zari, Drong, Alexander W., Eriksson, Per, Franco-Cereceda, Anders, Gådin, Jesper R., Gharavi, Ali G., Goddard, Michael E., Handsaker, Robert E., Huang, Jinyan, Karpe, Fredrik, Kathiresan, Sekar, Keildson, Sarah, Kiryluk, Krzysztof, Kubo, Michiaki, Lee, Jong-Young, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McCarroll, Steven A., McKnight, Amy J., Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Okada, Yukinori, Perry, John R. B., Dorajoo, Rajkumar, Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Scott, Robert A., Stolk, Lisette, Takahashi, Atsushi, Tanaka, Toshihiro, vanʼt Hooft, Ferdinand M., Vinkhuyzen, Anna A. E., Westra, Harm-Jan, Zheng, Wei, Zondervan, Krina T., Heath, Andrew C., Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Bovet, Pascal, Campbell, Harry, Caulfield, Mark J., Cesana, Giancarlo, Chakravarti, Aravinda, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Crawford, Dana C., Adrienne Cupples, L., Cusi, Daniele, Danesh, John, de Faire, Ulf, den Ruijter, Hester M., Dominiczak, Anna F., Erbel, Raimund, Erdmann, Jeanette, Eriksson, Johan G., Farrall, Martin, Felix, Stephan B., Ferrannini, Ele, Ferrières, Jean, Ford, Ian, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gejman, Pablo V., Gieger, Christian, Gottesman, Omri, Gudnason, Vilmundur, Gyllensten, Ulf, Hall, Alistair S., Harris, Tamara B., Hattersley, Andrew T., Hicks, Andrew A., Hindorff, Lucia A., Hingorani, Aroon D., Hofman, Albert, Homuth, Georg, Kees Hovingh, G., Humphries, Steve E., Hunt, Steven C., Hyppönen, Elina, Illig, Thomas, Jacobs, Kevin B., Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Johansen, Berit, Jousilahti, Pekka, Wouter Jukema, J., Jula, Antti M., Kaprio, Jaakko, Kastelein, John J. P., Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Knekt, Paul, Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Moll, Frans L., Morris, Andrew D., Morris, Andrew P., Murray, Jeffrey C., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Madden, Pamela A. F., Pasterkamp, Gerard, Peden, John F., Peters, Annette, Postma, Dirkje S., Pramstaller, Peter P., Price, Jackie F., Qi, Lu, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Rioux, John D., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schunkert, Heribert, Schwarz, Peter E. H., Sever, Peter, Shuldiner, Alan R., Sinisalo, Juha, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Trégouët, David-Alexandre, Tremblay, Angelo, Tremoli, Elena, Virtamo, Jarmo, Vohl, Marie-Claude, Völker, Uwe, Waeber, Gérard, Willemsen, Gonneke, Witteman, Jacqueline C., Carola Zillikens, M., Adair, Linda S., Amouyel, Philippe, Asselbergs, Folkert W., Assimes, Themistocles L., Bochud, Murielle, Boehm, Bernhard O., Boerwinkle, Eric, Bornstein, Stefan R., Bottinger, Erwin P., Bouchard, Claude, Cauchi, Stéphane, Chambers, John C., Chanock, Stephen J., Cooper, Richard S., de Bakker, Paul I. W., Dedoussis, George, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Groop, Leif C., Haiman, Christopher A., Hamsten, Anders, Hui, Jennie, Hunter, David J., Hveem, Kristian, Kaplan, Robert C., Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, Martin, Nicholas G., März, Winfried, Melbye, Mads, Metspalu, Andres, Moebus, Susanne, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sattar, Naveed, Schadt, Eric E., Schlessinger, David, Eline Slagboom, P., Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Walker, Mark, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wichmann, H-Erich, Wilson, James F., Zanen, Pieter, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Heid, Iris M., OʼConnell, Jeffrey R., Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Abecasis, Gonçalo R., Franke, Lude, Frayling, Timothy M., McCarthy, Mark I., Visscher, Peter M., Scherag, André, Willer, Cristen J., Boehnke, Michael, Mohlke, Karen L., Lindgren, Cecilia M., Beckmann, Jacques S., Barroso, Inês, North, Kari E., Ingelsson, Erik, Hirschhorn, Joel N., Loos, Ruth J. F., and Speliotes, Elizabeth K.
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- 2015
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173. New genetic loci link adipose and insulin biology to body fat distribution
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Shungin, Dmitry, Winkler, Thomas W., Croteau-Chonka, Damien C., Ferreira, Teresa, Locke, Adam E., Mägi, Reedik, Strawbridge, Rona J., Pers, Tune H., Fischer, Krista, Justice, Anne E., Workalemahu, Tsegaselassie, Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Roman, Tamara S., Drong, Alexander W., Song, Ci, Gustafsson, Stefan, Day, Felix R., Esko, Tonu, Fall, Tove, Kutalik, Zoltán, Luan, Jianʼan, Randall, Joshua C., Scherag, André, Vedantam, Sailaja, Wood, Andrew R., Chen, Jin, Fehrmann, Rudolf, Karjalainen, Juha, Kahali, Bratati, Liu, Ching-Ti, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Ehret, Georg B., Feitosa, Mary F., Goel, Anuj, Jackson, Anne U., Johnson, Toby, Kleber, Marcus E., Kristiansson, Kati, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Stančáková, Alena, Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Van Vliet-Ostaptchouk, Jana V., Yengo, Loïc, Zhang, Weihua, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blüher, Matthias, Böhringer, Stefan, Bonnet, Fabrice, Böttcher, Yvonne, Bruinenberg, Marcel, Carba, Delia B., Caspersen, Ida H., Clarke, Robert, Warwick Daw, E., Deelen, Joris, Deelman, Ewa, Delgado, Graciela, Doney, Alex S. F., Eklund, Niina, Erdos, Michael R., Estrada, Karol, Eury, Elodie, Friedrich, Nele, Garcia, Melissa E., Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Grallert, Harald, Grammer, Tanja B., Gräler, Jürgen, Grewal, Jagvir, Groves, Christopher J., Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heikkilä, Kauko, Herzig, Karl-Heinz, Helmer, Quinta, Hillege, Hans L., Holmen, Oddgeir, Hunt, Steven C., Isaacs, Aaron, Ittermann, Till, James, Alan L., Johansson, Ingegerd, Juliusdottir, Thorhildur, Kalafati, Ioanna-Panagiota, Kinnunen, Leena, Koenig, Wolfgang, Kooner, Ishminder K., Kratzer, Wolfgang, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Lobbens, Stéphane, Lorentzon, Mattias, Mach, François, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Mills, Rebecca, Moayyeri, Alireza, Monda, Keri L., Mooijaart, Simon P., Mühleisen, Thomas W., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Nagaraja, Ramaiah, Nalls, Michael A., Narisu, Narisu, Glorioso, Nicola, Nolte, Ilja M., Olden, Matthias, Rayner, Nigel W., Renstrom, Frida, Ried, Janina S., Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Sennblad, Bengt, Seufferlein, Thomas, Sitlani, Colleen M., Vernon Smith, Albert, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann-Christine, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tomaschitz, Andreas, Troffa, Chiara, van Oort, Floor V. A., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Wennauer, Roman, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Zhang, Qunyuan, Hua Zhao, Jing, Brennan, Eoin P., Choi, Murim, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Gharavi, Ali G., Hedman, Åsa K., Hivert, Marie-France, Huang, Jinyan, Kanoni, Stavroula, Karpe, Fredrik, Keildson, Sarah, Kiryluk, Krzysztof, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McKnight, Amy J., McPherson, Ruth, Metspalu, Andres, Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Olsson, Christian, Perry, John R. B., Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Schadt, Eric E., Scott, Robert A., Stolk, Lisette, Vallejo, Edgar E., Westra, Harm-Jan, Zondervan, Krina T., Amouyel, Philippe, Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Brown, Morris J., Burnier, Michel, Campbell, Harry, Chakravarti, Aravinda, Chines, Peter S., Claudi-Boehm, Simone, Collins, Francis S., Crawford, Dana C., Danesh, John, de Faire, Ulf, de Geus, Eco J. C., Dörr, Marcus, Erbel, Raimund, Eriksson, Johan G., Farrall, Martin, Ferrannini, Ele, Ferrières, Jean, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gieger, Christian, Gudnason, Vilmundur, Haiman, Christopher A., Harris, Tamara B., Hattersley, Andrew T., Heliövaara, Markku, Hicks, Andrew A., Hingorani, Aroon D., Hoffmann, Wolfgang, Hofman, Albert, Homuth, Georg, Humphries, Steve E., Hyppönen, Elina, Illig, Thomas, Jarvelin, Marjo-Riitta, Johansen, Berit, Jousilahti, Pekka, Jula, Antti M., Kaprio, Jaakko, Kee, Frank, Keinanen-Kiukaanniemi, Sirkka M., Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Musk, Arthur W., Möhlenkamp, Stefan, Morris, Andrew D., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Palmer, Lyle J., Penninx, Brenda W., Peters, Annette, Pramstaller, Peter P., Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schwarz, Peter E. H., Shuldiner, Alan R., Staessen, Jan A., Steinthorsdottir, Valgerdur, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Tremblay, Angelo, Tremoli, Elena, Vohl, Marie-Claude, Völker, Uwe, Vollenweider, Peter, Wilson, James F., Witteman, Jacqueline C., Adair, Linda S., Bochud, Murielle, Boehm, Bernhard O., Bornstein, Stefan R., Bouchard, Claude, Cauchi, Stéphane, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Cooper, Richard S., Dedoussis, George, Ferrucci, Luigi, Froguel, Philippe, Grabe, Hans-Jörgen, Hamsten, Anders, Hui, Jennie, Hveem, Kristian, Jöckel, Karl-Heinz, Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, März, Winfried, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sinisalo, Juha, Eline Slagboom, P., Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Veronesi, Giovanni, Walker, Mark, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H-Erich, Abecasis, Goncalo R., Assimes, Themistocles L., Berndt, Sonja I., Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Franke, Lude, Frayling, Timothy M., Groop, Leif C., Hunter, David J., Kaplan, Robert C., OʼConnell, Jeffrey R., Qi, Lu, Schlessinger, David, Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Willer, Cristen J., Visscher, Peter M., Yang, Jian, Hirschhorn, Joel N., Carola Zillikens, M., McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Fox, Caroline S., Barroso, Inês, Franks, Paul W., Ingelsson, Erik, Heid, Iris M., Loos, Ruth J. F., Cupples, Adrienne L., Morris, Andrew P., Lindgren, Cecilia M., and Mohlke, Karen L
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- 2015
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174. HNF1B-associated renal and extra-renal disease—an expanding clinical spectrum
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Clissold, Rhian L., Hamilton, Alexander J., Hattersley, Andrew T., Ellard, Sian, and Bingham, Coralie
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- 2015
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175. Most People With Long-Duration Type 1 Diabetes in a Large Population-Based Study Are Insulin Microsecretors
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Oram, Richard A., McDonald, Timothy J., Shields, Beverley M., Hudson, Michelle M., Shepherd, Maggie H., Hammersley, Suzanne, Pearson, Ewan R., and Hattersley, Andrew T.
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- 2015
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176. Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: a joint modeling approach
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Dennis,John M., Shields,Beverley M., Jones,Angus G., Pearson,Ewan R., Hattersley,Andrew T., and Henley,William E.
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HbA1c ,precision medicine ,ADOPT ,hypoglycemia ,type 2 ,diabetes mellitus ,sulfonylurea compounds ,Clinical Epidemiology ,drug-related side effects ,metformin ,thiazolidinediones ,edema ,Original Research ,joint model - Abstract
John M Dennis,1 Beverley M Shields,2 Angus G Jones,2 Ewan R Pearson,3 Andrew T Hattersley,2 William E Henley1 On behalf of the MASTERMIND consortium 1Health Statistics Group, University of Exeter Medical School, Exeter, UK; 2National Institute for Health Research Exeter Clinical Research Facility, University of Exeter Medical School, Exeter, UK; 3Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK Objective: Precision medicine drug therapy seeks to maximize efficacy and minimize harm for individual patients. This will be difficult if drug response and side effects are positively associated, meaning that patients likely to respond best are at increased risk of side effects. We applied joint longitudinal–survival models to evaluate associations between drug response (longitudinal outcome) and the risk of side effects (survival outcome) for patients initiating type 2 diabetes therapy. Study design and setting: Participants were randomized to metformin (MFN), sulfonylurea(SU), or thiazolidinedione (TZD) therapy in the A Diabetes Outcome Progression Trial (ADOPT) drug efficacy trial (n=4,351). Joint models were parameterized for 1) current HbA1c response (change from baseline in HbA1c) and 2) cumulative HbA1c response (total HbA1c change). Results: With MFN, greater HbA1c response did not increase the risk of gastrointestinal events (HR per 1% absolute greater current response 0.82 [95% CI 0.67, 1.01]; HR per 1% higher cumulative response 0.90 [95% CI 0.81, 1.00]). With SU, greater current response was associated with an increased risk of hypoglycemia (HR 1.41 [95% CI 1.04, 1.91]). With TZD, greater response was associated with an increased risk of edema (current HR 1.45 [95% CI 1.05, 2.01]; cumulative 1.22 [95% CI 1.07, 1.38]) but not fracture. Conclusion: Joint modeling provides a useful framework to evaluate the association between response to a drug and the risk of developing side effects. There may be great potential for widespread application of joint modeling to evaluate the risks and benefits of both new and established medications. Keywords: diabetes mellitus, type 2, drug-related side effects, HbA1c, hypoglycemia, joint model, precision medicine, thiazolidinediones, metformin, sulfonylurea compounds, ADOPT, edema
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- 2018
177. Additional file 5 of Choice of HbA1c threshold for identifying individuals at high risk of type 2 diabetes and implications for diabetes prevention programmes: a cohort study
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Rodgers, Lauren R., Hill, Anita V., Dennis, John M., Craig, Zoe, May, Benedict, Hattersley, Andrew T., McDonald, Timothy J., Andrews, Rob C., Jones, Angus, and Shields, Beverley M.
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endocrine system diseases ,nutritional and metabolic diseases - Abstract
Additional file 5. Kaplan-Meier survival plot by HbA1c category.
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- 2021
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178. Additional file 3 of Choice of HbA1c threshold for identifying individuals at high risk of type 2 diabetes and implications for diabetes prevention programmes: a cohort study
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Rodgers, Lauren R., Hill, Anita V., Dennis, John M., Craig, Zoe, May, Benedict, Hattersley, Andrew T., McDonald, Timothy J., Andrews, Rob C., Jones, Angus, and Shields, Beverley M.
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health care economics and organizations - Abstract
Additional file 3. Sensitivity analysis excluding data after the launch of the UK diabetes prevention programme.
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- 2021
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179. Additional file 2 of Choice of HbA1c threshold for identifying individuals at high risk of type 2 diabetes and implications for diabetes prevention programmes: a cohort study
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Rodgers, Lauren R., Hill, Anita V., Dennis, John M., Craig, Zoe, May, Benedict, Hattersley, Andrew T., McDonald, Timothy J., Andrews, Rob C., Jones, Angus, and Shields, Beverley M.
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Additional file 2. Leicester Risk Score.
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- 2021
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180. The power of genetic diversity in genome-wide association studies of lipids
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Graham, Sarah E. Clarke, Shoa L. Wu, Kuan-Han H. Kanoni, Stavroula Zajac, Greg J. M. Ramdas, Shweta Surakka, Ida and Ntalla, Ioanna Vedantam, Sailaja Winkler, Thomas W. Locke, Adam E. Marouli, Eirini Hwang, Mi Yeong Han, Sohee and Narita, Akira Choudhury, Ananyo Bentley, Amy R. Ekoru, Kenneth Verma, Anurag Trivedi, Bhavi Martin, Hilary C. and Hunt, Karen A. Hui, Qin Klarin, Derek Zhu, Xiang and Thorleifsson, Gudmar Helgadottir, Anna Gudbjartsson, Daniel F. and Holm, Hilma Olafsson, Isleifur Akiyama, Masato Sakaue, Saori Terao, Chikashi Kanai, Masahiro Zhou, Wei and Brumpton, Ben M. Rasheed, Humaira Ruotsalainen, Sanni E. and Havulinna, Aki S. Veturi, Yogasudha Feng, QiPing Rosenthal, Elisabeth A. Lingren, Todd Pacheco, Jennifer Allen and Pendergrass, Sarah A. Haessler, Jeffrey Giulianini, Franco and Bradford, Yuki Miller, Jason E. Campbell, Archie Lin, Kuang and Millwood, Iona Y. Hindy, George Rasheed, Asif Faul, Jessica D. Zhao, Wei Weir, David R. Turman, Constance and Huang, Hongyan Graff, Mariaelisa Mahajan, Anubha Brown, Michael R. Zhang, Weihua Yu, Ketian Schmidt, Ellen M. and Pandit, Anita Gustafsson, Stefan Yin, Xianyong Luan, Jian'an and Zhao, Jing-Hua Matsuda, Fumihiko Jang, Hye-Mi Yoon, Kyungheon Medina-Gomez, Carolina Pitsillides, Achilleas and Hottenga, Jouke Jan Willemsen, Gonneke Wood, Andrew R. Ji, Yingji Gao, Zishan Haworth, Simon Mitchell, Ruth E. and Chai, Jin Fang Aadahl, Mette Yao, Jie Manichaikul, Ani and Warren, Helen R. Ramirez, Julia Bork-Jensen, Jette Karhus, Line L. Goel, Anuj Sabater-Lleal, Maria Noordam, Raymond and Sidore, Carlo Fiorillo, Edoardo McDaid, Aaron F. and Marques-Vidal, Pedro Wielscher, Matthias Trompet, Stella and Sattar, Naveed Mollehave, Line T. Thuesen, Betina H. Munz, Matthias Zeng, Lingyao Huang, Jianfeng Yang, Bin Poveda, Alaitz Kurbasic, Azra Lamina, Claudia Forer, Lukas and Scholz, Markus Galesloot, Tessel E. Bradfield, Jonathan P. and Daw, E. Warwick Zmuda, Joseph M. Mitchell, Jonathan S. and Fuchsberger, Christian Christensen, Henry Brody, Jennifer A. and Feitosa, Mary F. Wojczynski, Mary K. Preuss, Michael and Mangino, Massimo Christofidou, Paraskevi Verweij, Niek and Benjamins, Jan W. Engmann, Jorgen Kember, Rachel L. Slieker, Roderick C. Lo, Ken Sin Zilhao, Nuno R. Phuong Le and Kleber, Marcus E. Delgado, Graciela E. Huo, Shaofeng Ikeda, Daisuke D. Iha, Hiroyuki Yang, Jian Liu, Jun Leonard, Hampton L. Marten, Jonathan Schmidt, Borge Arendt, Marina and Smyth, Laura J. Canadas-Garre, Marisa Wang, Chaolong and Nakatochi, Masahiro Wong, Andrew Hutri-Kahonen, Nina Sim, Xueling Xia, Rui Huerta-Chagoya, Alicia Fernandez-Lopez, Juan Carlos Lyssenko, Valeriya Ahmed, Meraj Jackson, Anne U. and Irvin, Marguerite R. Oldmeadow, Christopher Kim, Han-Na and Ryu, Seungho Timmers, Paul R. H. J. Arbeeva, Liubov Dorajoo, Rajkumar Lange, Leslie A. Chai, Xiaoran Prasad, Gauri and Lores-Motta, Laura Pauper, Marc Long, Jirong Li, Xiaohui and Theusch, Elizabeth Takeuchi, Fumihiko Spracklen, Cassandra N. and Loukola, Anu Bollepalli, Sailalitha Warner, Sophie C. and Wang, Ya Xing Wei, Wen B. Nutile, Teresa Ruggiero, Daniela and Sung, Yun Ju Hung, Yi-Jen Chen, Shufeng Liu, Fangchao and Yang, Jingyun Kentistou, Katherine A. Gorski, Mathias and Brumat, Marco Meidtner, Karina Bielak, Lawrence F. Smith, Jennifer A. Hebbar, Prashantha Farmaki, Aliki-Eleni Hofer, Edith Lin, Maoxuan Xue, Chao Zhang, Jifeng Concas, Maria Pina Vaccargiu, Simona van der Most, Peter J. Pitkanen, Niina Cade, Brian E. Lee, Jiwon van Der Laan, Sander W. and Chitrala, Kumaraswamy Naidu Weiss, Stefan Zimmermann, Martina E. and Lee, Jong Young Choi, Hyeok Sun Nethander, Maria and Freitag-Wolf, Sandra Southam, Lorraine Rayner, Nigel W. and Wang, Carol A. Lin, Shih-Yi Wang, Jun-Sing Couture, Christian Lyytikainen, Leo-Pekka Nikus, Kjell and Cuellar-Partida, Gabriel Vestergaard, Henrik Hildalgo, Bertha and Giannakopoulou, Olga Cai, Qiuyin Obura, Morgan O. van Setten, Jessica Li, Xiaoyin Schwander, Karen Terzikhan, Natalie Shin, Jae Hun Jackson, Rebecca D. Reiner, Alexander P. Martin, Lisa Warsinger Chen, Zhengming Li, Liming and Highland, Heather M. Young, Kristin L. Kawaguchi, Takahisa and Thiery, Joachim Bis, Joshua C. Nadkarni, Girish N. Launer, Lenore J. Li, Huaixing Nalls, Mike A. Raitakari, Olli T. and Ichihara, Sahoko Wild, Sarah H. Nelson, Christopher P. and Campbell, Harry Jager, Susanne Nabika, Toru Al-Mulla, Fahd and Niinikoski, Harri Braund, Peter S. Kolcic, Ivana Kovacs, Peter Giardoglou, Tota Katsuya, Tomohiro Bhatti, Fatima and de Kleijn, Dominique de Borst, Gert J. Kim, Eung Kweon and Adams, Hieab H. H. Ikram, M. Arfan Zhu, Xiaofeng Asselbergs, Folkert W. Kraaijeveld, Adriaan O. Beulens, Joline W. J. and Shu, Xiao-Ou Rallidis, Loukianos S. Pedersen, Oluf Hansen, Torben Mitchell, Paul Hewitt, Alex W. Kahonen, Mika and Perusse, Louis Bouchard, Claude Tonjes, Anke Chen, Yii-Der Ida Pennell, Craig E. Mori, Trevor A. Lieb, Wolfgang and Franke, Andre Ohlsson, Claes Mellstrom, Dan Cho, Yoon Shin and Lee, Hyejin Yuan, Jian-Min Koh, Woon-Puay Rhee, Sang Youl Woo, Jeong-Taek Heid, Iris M. Stark, Klaus J. and Volzke, Henry Homuth, Georg Evans, Michele K. Zonderman, Alan B. Polasek, Ozren Pasterkamp, Gerard Hoefer, Imo E. and Redline, Susan Pahkala, Katja Oldehinkel, Albertine J. and Snieder, Harold Biino, Ginevra Schmidt, Reinhold Schmidt, Helena Chen, Y. Eugene Bandinelli, Stefania Dedoussis, George Thanaraj, Thangavel Alphonse Kardia, Sharon L. R. and Kato, Norihiro Schulze, Matthias B. Girotto, Giorgia Jung, Bettina Boger, Carsten A. Joshi, Peter K. Bennett, David A. and De Jager, Philip L. Lu, Xiangfeng Mamakou, Vasiliki and Brown, Morris Caulfield, Mark J. Munroe, Patricia B. Guo, Xiuqing Ciullo, Marina Jonas, Jost B. Samani, Nilesh J. and Kaprio, Jaakko Pajukanta, Paivi Adair, Linda S. Bechayda, Sonny Augustin de Silva, H. Janaka Wickremasinghe, Ananda R. and Krauss, Ronald M. Wu, Jer-Yuarn Zheng, Wei den Hollander, I, Anneke Bharadwaj, Dwaipayan Correa, Adolfo Wilson, James G. and Lind, Lars Heng, Chew-Kiat Nelson, Amanda E. Golightly, Yvonne M. Wilson, James F. Penninx, Brenda Kim, Hyung-Lae and Attia, John Scott, Rodney J. Rao, D. C. Arnett, Donna K. and Walker, Mark Koistinen, Heikki A. Chandak, Giriraj R. and Yajnik, Chittaranjan S. Mercader, Josep M. Tusie-Luna, Teresa and Aguilar-Salinas, Carlos A. Villalpando, Clicerio Gonzalez and Orozco, Lorena Fornage, Myriam Tai, E. Shyong van Dam, Rob M. Lehtimaki, Terho Chaturvedi, Nish Yokota, Mitsuhiro and Liu, Jianjun Reilly, Dermot F. McKnight, Amy Jayne Kee, Frank Jockel, Karl-Heinz McCarthy, I, Mark Palmer, Colin N. A. Vitart, Veronique Hayward, Caroline Simonsick, Eleanor and van Duijn, Cornelia M. Lu, Fan Qu, Jia Hishigaki, Haretsugu Lin, Xu Marz, Winfried Parra, Esteban J. Cruz, Miguel Gudnason, Vilmundur Tardif, Jean-Claude Lettre, Guillaume `t Hart, Leen M. Elders, Petra J. M. Damrauer, Scott M. Kumari, Meena Kivimaki, Mika van der Harst, Pim and Spector, Tim D. Loos, Ruth J. F. Province, Michael A. Psaty, Bruce M. Brandslund, Ivan Pramstaller, Peter P. Christensen, Kaare Ripatti, Samuli Widen, Elisabeth Hakonarson, Hakon and Grant, Struan F. A. Kiemeney, Lambertus A. L. M. de Graaf, Jacqueline Loeffler, Markus Kronenberg, Florian Gu, Dongfeng and Erdmann, Jeanette Schunkert, Heribert Franks, Paul W. and Linneberg, Allan Jukema, J. Wouter Khera, V, Amit Mannikko, Minna Jarvelin, Marjo-Riitta Kutalik, Zoltan Cucca, Francesco Mook-Kanamori, Dennis O. van Dijk, Ko Willems and Watkins, Hugh Strachan, David P. Grarup, Niels Sever, Peter and Poulter, Neil Rotter, I, Jerome Dantoft, Thomas M. and Karpe, Fredrik Neville, Matt J. Timpson, Nicholas J. Cheng, Ching-Yu Wong, Tien-Yin Khor, Chiea Chuen Sabanayagam, Charumathi Peters, Annette Gieger, Christian Hattersley, Andrew T. Pedersen, Nancy L. Magnusson, Patrik K. E. and Boomsma, I, Dorret de Geus, Eco J. C. Cupples, L. Adrienne and van Meurs, Joyce B. J. Ghanbari, Mohsen Rsen, Penny Gordon-La and Huang, Wei Kim, Young Jin Tabara, Yasuharu Wareham, Nicholas J. Langenberg, Claudia Zeggini, Eleftheria and Kuusisto, Johanna Laakso, Markku Ingelsson, Erik Abecasis, Goncalo Chambers, John C. Kooner, Jaspal S. de Vries, Paul S. Morrison, Alanna C. North, Kari E. Daviglus, Martha and Kraft, Peter Martin, Nicholas G. Whitfield, John B. Abbas, Shahid Saleheen, Danish Walters, Robin G. Holmes, V, Michael and Black, Corri Smith, Blair H. Justice, Anne E. Baras, Aris Buring, Julie E. Ridker, Paul M. Chasman, I, Daniel and Kooperberg, Charles Wei, Wei-Qi Jarvik, Gail P. Namjou, Bahram Hayes, M. Geoffrey Ritchie, Marylyn D. Jousilahti, Pekka Salomaa, Veikko Hveem, Kristian Asvold, Bjorn Olav and Kubo, Michiaki Kamatani, Yoichiro Okada, Yukinori Murakami, Yoshinori Thorsteinsdottir, Unnur Stefansson, Kari Ho, Yuk-Lam Lynch, Julie A. Rader, Daniel J. Tsao, Philip S. and Chang, Kyong-Mi Cho, Kelly O'Donnell, Christopher J. and Gaziano, John M. Wilson, Peter Rotimi, Charles N. and Hazelhurst, Scott Ramsay, Michele Trembath, Richard C. van Heel, David A. Tamiya, Gen Yamamoto, Masayuki Kim, Bong-Jo and Mohlke, Karen L. Frayling, Timothy M. Hirschhorn, Joel N. and Kathiresan, Sekar Boehnke, Michael Natarajan, Pradeep and Peloso, Gina M. Brown, Christopher D. Morris, Andrew P. and Assimes, Themistocles L. Deloukas, Panos Sun, V, Yan Willer, Cristen J.
- Abstract
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use(1). Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels(2), heart disease remains the leading cause of death worldwide(3). Genome-wideassociation studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS(4-23) have been conducted in European ancestry populations and may have missed genetic variants that contribute to lipid-level variation in other ancestry groups. These include differences in allele frequencies, effect sizes and linkage-disequilibrium patterns(24). Here we conduct a multi-ancestry, genome-wide genetic discovery meta-analysis of lipid levels in approximately 1.65 million individuals, including 350,000 of non-European ancestries. We quantify the gain in studying non-European ancestries and provide evidence to support the expansion of recruitment of additional ancestries, even with relatively small sample sizes. We find that increasing diversity rather than studying additional individuals of European ancestry results in substantial improvements in fine-mapping functional variants and portability of polygenic prediction (evaluated in approximately 295,000 individuals from 7 ancestry groupings). Modest gains in the number of discovered loci and ancestry-specific variants were also achieved. As GWAS expand emphasis beyond the identification of genes and fundamental biology towards the use of genetic variants for preventive and precision medicine(25), we anticipate that increased diversity of participants will lead to more accurate and equitable(26) application of polygenic scores in clinical practice.
- Published
- 2021
181. Extended data Wellcome Open Research 16097.pdf
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Hughes, Alice, M. Geoffrey Hayes, Egan, Aoife M., Kashyap A Patel, Scholtens, Denise M., Lowe, Lynn P., Lowe, William L., Dunne, Fidelma PM, Hattersley, Andrew T., and Freathy, Rachel M.
- Abstract
Extended data file for Wellcome Open Research manuscript (16097) Hughes AE, Hayes MG, Egan AM et al. All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes.
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- 2021
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182. Loss of MANF causes childhood-onset syndromic diabetes due to increased endoplasmic reticulum stress
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Acar, Sezer, Balboa, Diego, Ibrahim, Hazem, Lithovius, Vaino, Naatanen, Anna, Montaser, Hossam, Ben-Omran, Tawfeg, Lindahl, Maria, Saarimaki-Vire, Jonna, Otonkoski, Timo, Patel, Kashyap A., Colclough, Kevin, Locke, Jonathan M., Wakeling, Matthew, Hattersley, Andrew T., DEMİR, KORCAN, Chandra, Vikash, STEMM - Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Centre of Excellence in Stem Cell Metabolism, Institute for Molecular Medicine Finland, Helsinki One Health (HOH), Molecular and Integrative Biosciences Research Programme, Institute of Biotechnology, Clinicum, Children's Hospital, Timo Pyry Juhani Otonkoski / Principal Investigator, and HUS Children and Adolescents
- Subjects
Estrès ,Diabetis ,3121 General medicine, internal medicine and other clinical medicine ,Diabetis infantil ,Proteïnes ,Sistema nerviós -- Malalties ,Genètica - Abstract
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-resident protein that plays a crucial role in attenuating ER stress responses. Although MANF is indispensable for the survival and function of mouse β-cells, its precise role in human β-cell development and function is unknown. In this study, we show that lack of MANF in humans results in diabetes due to increased ER stress, leading to impaired β-cell function. We identified two patients from different families with childhood diabetes and a neurodevelopmental disorder associated with homozygous loss-of-function mutations in the MANF gene. To study the role of MANF in human β-cell development and function, we knocked out the MANF gene in human embryonic stem cells and differentiated them into pancreatic endocrine cells. Loss of MANF induced mild ER stress and impaired insulin-processing capacity of β-cells in vitro. Upon implantation to immunocompromised mice, the MANF knockout grafts presented elevated ER stress and functional failure, particularly in recipients with diabetes. By describing a new form of monogenic neurodevelopmental diabetes syndrome caused by disturbed ER function, we highlight the importance of adequate ER stress regulation for proper human β-cell function and demonstrate the crucial role of MANF in this process. Funding: the genetic studies were funded by Wellcome Trust awarded to Kashyp Patel (grant 110082/Z/15/Z). Kashyp Patel is a Wellcome trust Fellow (grant 219606/Z/19/Z). A.T.H. is a Wellcome Trust Senior Investigator (WT098395/Z/12/Z). The experimental studies were funded by the Academy of Findland (grant 297466 and MetaStem Center of Excellence grant 312437), the Sigrid Jusélius Foundation, the Novo Nordisk Foundation and the JDRF (Grant 2-SRA-2018-496-A-B, PI Mart Saarma, co-PI TO)
- Published
- 2021
183. Additional file 4 of Choice of HbA1c threshold for identifying individuals at high risk of type 2 diabetes and implications for diabetes prevention programmes: a cohort study
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Rodgers, Lauren R., Hill, Anita V., Dennis, John M., Craig, Zoe, May, Benedict, Hattersley, Andrew T., McDonald, Timothy J., Andrews, Rob C., Jones, Angus, and Shields, Beverley M.
- Subjects
endocrine system diseases ,nutritional and metabolic diseases - Abstract
Additional file 4. Absolute 5 year risk of developing Type 2 diabetes given baseline HbA1c.
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- 2021
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184. Phenotypic severity of homozygous GCK mutations causing neonatal or childhood-onset diabetes is primarily mediated through effects on protein stability
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Raimondo, Anne, Chakera, Ali J., Thomsen, Soren K., Colclough, Kevin, Barrett, Amy, De Franco, Elisa, Chatelas, Alisson, Demirbilek, Huseyin, Akcay, Teoman, Alawneh, Hussein, Flanagan, Sarah E., Van De Bunt, Martijn, Hattersley, Andrew T., Gloyn, Anna L., Ellard, Sian, Abduljabbar, Mohammad A., Al-Zyoud, Mahmoud, Aman, Syed, Bath, Louise, De, Parijat, Deshpande, Neeta, Durmaz, Erdem, Eickmeier, Frank, Elbarbary, Nancy Samir, Fillion, Marc, Jagadeesh, Sujatha M., Kershaw, Melanie, Khan, Waqas I., Mlynarski, Wojciech, Noyes, Kathryn, Peters, Catherine J., Shaw, Nick, Tiron, Irina, Turkkahraman, Doga, Turner, Lesley, Eltonbary, Khadiga Y., and Yuksel, Bilgin
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- 2014
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185. Reappearance of C-Peptide During the Third Trimester of Pregnancy in Type 1 Diabetes: Pancreatic Regeneration or Fetal Hyperinsulinism?
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Meek, Claire L., primary, Oram, Richard A., additional, McDonald, Timothy J., additional, Feig, Denice S., additional, Hattersley, Andrew T., additional, and Murphy, Helen R., additional
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- 2021
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186. Reappearance of C-Peptide During the Third Trimester of Pregnancy in Type 1 Diabetes: Pancreatic Regeneration or Fetal Hyperinsulinism?
- Author
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Meek, Claire L, primary, Oram, Richard A, primary, McDonald, Timothy J, primary, Feig, Denice S, primary, Hattersley, Andrew T, primary, Murphy, Helen R, primary, and group, the CONCEPTT collaborative, primary
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- 2021
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187. Identification of GCK‐ maturity‐onset diabetes of the young in cases of neonatal hyperglycemia: A case series and review of clinical features
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Hughes, Alice E., primary, De Franco, Elisa, additional, Globa, Evgenia, additional, Zelinska, Nataliya, additional, Hilgard, Dörte, additional, Sifianou, Popi, additional, Hattersley, Andrew T., additional, and Flanagan, Sarah E., additional
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- 2021
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188. 94-OR: Reappearance of C-Peptide during the Third Trimester in Type 1 Diabetes Pregnancy: Pancreatic Regeneration or Fetal Hyperinsulinism?
- Author
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MEEK, CLAIRE L., primary, ORAM, RICHARD A., additional, MCDONALD, TIMOTHY J., additional, FEIG, DENICE, additional, HATTERSLEY, ANDREW T., additional, and MURPHY, HELEN R., additional
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- 2021
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189. Latent Autoimmune Diabetes of Adults (LADA) Is Likely to Represent a Mixed Population of Autoimmune (Type 1) and Nonautoimmune (Type 2) Diabetes
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Jones, Angus G., primary, McDonald, Timothy J., additional, Shields, Beverley M., additional, Hagopian, William, additional, and Hattersley, Andrew T., additional
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- 2021
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190. 954-P: In Gestational Diabetes, Patient-Led Insulin Titration Is Rapidly Effective without Detrimental Hypoglycaemia
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MAYNE, ISABELLE K., primary, THOMAS, NICHOLAS, additional, HATTERSLEY, ANDREW T., additional, and MCGOVERN, ANDREW P., additional
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- 2021
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191. Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes
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Hiller, Helmut, primary, Beachy, Dawn E., primary, Lebowitz, Joseph J., primary, Engler, Stefanie, primary, Mason, Justin R., primary, Miller, Douglas R., primary, Kusmarteva, Irina, primary, Jacobsen, Laura M., primary, Posgai, Amanda L., primary, Khoshbouei, Habibeh, primary, Oram, Richard A., primary, Schatz, Desmond A., primary, Hattersley, Andrew T., primary, Bodenmiller, Bernd, primary, Atkinson, Mark A., primary, Nick, Harry S., primary, and Wasserfall, Clive H., primary
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- 2021
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192. Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene
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Akerman, Ildem, primary, Maestro, Miguel Angel, additional, De Franco, Elisa, additional, Grau, Vanessa, additional, Flanagan, Sarah, additional, García-Hurtado, Javier, additional, Mittler, Gerhard, additional, Ravassard, Philippe, additional, Piemonti, Lorenzo, additional, Ellard, Sian, additional, Hattersley, Andrew T., additional, and Ferrer, Jorge, additional
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- 2021
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193. Cross-sectional and longitudinal studies suggest pharmacological treatment used in patients with glucokinase mutations does not alter glycaemia
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Stride, Amanda, Shields, Beverley, Gill-Carey, Olivia, Chakera, Ali J., Colclough, Kevin, Ellard, Sian, and Hattersley, Andrew T.
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- 2014
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194. The fat mass–and obesity-associated locus and dietary intake in children
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Timpson, Nicholas J, Emmett, Pauline M, Frayling, Timothy M, Rogers, Imogen, Hattersley, Andrew T, McCarthy, Mark I, and Davey Smith, George
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- 2008
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195. The diagnosis and management of monogenic diabetes in children and adolescents
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Rubio-Cabezas, Oscar, Hattersley, Andrew T, Njlstad, Pål R, Mlynarski, Wojciech, Ellard, Sian, White, Neil, Chi, Dung Vu, and Craig, Maria E
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- 2014
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196. GATA4 Mutations Are a Cause of Neonatal and Childhood-Onset Diabetes
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Shaw-Smith, Charles, De Franco, Elisa, Lango Allen, Hana, Batlle, Marta, Flanagan, Sarah E., Borowiec, Maciej, Taplin, Craig E., van Alfen-van der Velden, Janiëlle, Cruz-Rojo, Jaime, Perez de Nanclares, Guiomar, Miedzybrodzka, Zosia, Deja, Grazyna, Wlodarska, Iwona, Mlynarski, Wojciech, Ferrer, Jorge, Hattersley, Andrew T., and Ellard, Sian
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- 2014
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197. Permanent neonatal diabetes in siblings with novel C109Y INS mutation transmitted by an unaffected parent with somatic mosaicism
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Bee, Yong Mong, Zhao, Yi, Ellard, Sian, Hattersley, Andrew T, and Yap, Fabian
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- 2014
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198. Physiology Helps GWAS Take a Step Closer to Mechanism
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Frayling, Timothy M. and Hattersley, Andrew T.
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- 2014
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199. Home Urine C-Peptide Creatinine Ratio Can Be Used to Monitor Islet Transplant Function
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Oram, Richard A., Brooks, Augustin M., Forbes, Shareen, Eckoldt, Stephanie, Smith, Richard M., Choudhary, Pratik, Rosenthal, Miranda J., Johnson, Paul, Rutter, Martin K., Burling, Keith A., McDonald, Timothy J., Shaw, James A.M., and Hattersley, Andrew T.
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- 2014
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200. Effect of the Holiday Season in Patients With Diabetes: Glycemia and Lipids Increase Postholiday, but the Effect Is Small and Transient
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Jones, Angus G., McDonald, Timothy J., Hattersley, Andrew T., and Shields, Beverley M.
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- 2014
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