151. Production of albumin and other serum proteins by clonal cultures of normal human liver.
- Author
-
Kaighn ME and Prince AM
- Subjects
- Adult, Age Factors, Blood Proteins analysis, Carbon Isotopes, Cell Division, Clone Cells cytology, Complement System Proteins biosynthesis, Epithelial Cells, Fetus cytology, Fibrinogen biosynthesis, Fibroblasts, Glycoproteins biosynthesis, Haptoglobins biosynthesis, Humans, Immunodiffusion, Immunoelectrophoresis, Infant, Lipoproteins biosynthesis, Liver metabolism, Macroglobulins biosynthesis, Radioimmunoassay, Serum Albumin biosynthesis, Transferrin biosynthesis, Blood Proteins biosynthesis, Clone Cells metabolism, Liver cytology
- Abstract
Clonal cell strains have been isolated from normal human liver. These cells, while resembling fibroblasts morphologically, function as hepatocytes, as shown by their ability to synthesize and secrete an antigen identical to human serum albumin. Human diploid and aneuploid cell lines from nonliver sources do not exhibit this property. The spectrum of serum proteins synthesized varied from clone to clone and cell line to cell line.
- Published
- 1971
- Full Text
- View/download PDF