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1,283 results on '"Hanson, Robert L."'

153. Genome-Wide Scans for Diabetic Nephropathy and Albuminuria in Multiethnic Populations: The Family Investigation of Nephropathy and Diabetes (FIND)

Author

Iyengar, Sudha K., Abboud, Hanna E., Goddard, Katrina A.B., Saad, Mohammed F., Adler, Sharon G., Arar, Nedal H., Bowden, Donald W., Duggirala, Ravi, Elston, Robert C., Hanson, Robert L., Ipp, Eli, Kao, W. H. Linda, Kimmel, Paul L., Klag, Michael J., Knowler, William C., Meoni, Lucy A., Nelson, Robert G., Nicholas, Susanne B., Pahl, Madeleine V., Parekh, Rulan S., Quade, Shannon R.E., Rich, Stephen S., Rotter, Jerome I., Scavini, Marina, Schelling, Jeffrey R., Sedor, John R., Sehgal, Ashwini R., Shah, Vallabh O., Smith, Michael W., Taylor, Kent D., Winkler, Cheryl A., Zager, Philip G., and Freedman, Barry I.

Published
2007

160. An autosomal genomic scan for loci linked to type II diabetes mellitus and body-mass index in Pima Indians

Author

Hanson, Robert L., Ehm, Margaret G., Pettitt, David J., Prochazka, Michal, Thompson, D. Bruce, Timberlake, David, Foroud, Tatiana, Kobes, Sayuko, Baier, Leslie, Burns, Daniel K., Almasy, Laura, Blangero, John, Garvey, W. Timothy, Bennett, Peter H., and Knowler, William C.

Subjects
Native Americans -- Health aspects, Diabetes -- Research, Body size -- Health aspects, Genetic disorders -- Research, Biological sciences
Abstract

Various research methods have been used to identify genetic loci for type II diabetes mellitus occurring in Pima Native Americans. These included variance-components methodology, and multipoint, bivariate linkage and sib-pair analyses, and were adjusted for age and body-mass index. Results indicate potential loci on chromosomes 1q and 7q for diabetes susceptibility.

Published
1998

161. Variants in the [Ca.sub.v]2.3 (α1E) subunit of voltage-activated [Ca.sup.2+] channels are associated with insulin resistance and type 2 diabetes in Pima Indians

Author

Muller, Yunhua Li, Hanson, Robert L., Zimmerman, Collin, Harper, Inge, Sutherland, Jeff, Kobes, Sayuko, Knowler, William C., Bogardus, Clifton, and Baier, Leslie J.

Subjects
Genetic variation -- Research -- Health aspects -- Genetic aspects, Single nucleotide polymorphisms -- Health aspects -- Research -- Genetic aspects, Type 2 diabetes -- Risk factors -- Genetic aspects -- Research, Health, Research, Genetic aspects, Risk factors, Health aspects
Abstract

OBJECTIVE--Linkage to type 2 diabetes has been reported on chromosome 1q21-25 in Pima Indians. Fine mapping identified single nucleotide polymorphisms (SNPs) near the CACNA1E gene associated with this disease. CACNA1E [...]

Published
2007

162. IL6 Gene Promoter Polymorphisms and Type 2 Diabetes: Joint Analysis of Individual Participantsʼ Data From 21 Studies

Author

Huth, Cornelia, Heid, Iris M., Vollmert, Caren, Gieger, Christian, Grallert, Harald, Wolford, Johanna K., Langer, Birgit, Thorand, Barbara, Klopp, Norman, Hamid, Yasmin H., Pedersen, Oluf, Hansen, Torben, Lyssenko, Valeriya, Groop, Leif, Meisinger, Christa, Döring, Angela, Löwel, Hannelore, Lieb, Wolfgang, Hengstenberg, Christian, Rathmann, Wolfgang, Martin, Stephan, Stephens, Jeffrey W., Ireland, Helen, Mather, Hugh, Miller, George J., Stringham, Heather M., Boehnke, Michael, Tuomilehto, Jaakko, Boeing, Heiner, Möhlig, Matthias, Spranger, Joachim, Pfeiffer, Andreas, Wernstedt, Ingrid, Niklason, Anders, López-Bermejo, Abel, Fernández-Real, José-Manuel, Hanson, Robert L., Gallart, Luis, Vendrell, Joan, Tsiavou, Anastasia, Hatziagelaki, Erifili, Humphries, Steve E., Wichmann, H.-Erich, Herder, Christian, and Illig, Thomas

Published
2006

163. Variation Within the Gene Encoding the Upstream Stimulatory Factor 1 Does Not Influence Susceptibility to Type 2 Diabetes in Samples From Populations With Replicated Evidence of Linkage to Chromosome 1q

Author

Zeggini, Eleftheria, Damcott, Coleen M., Hanson, Robert L., Karim, Mohammad A., Rayner, N. William, Groves, Christopher J., Baier, Leslie J., Hale, Terri C., Hattersley, Andrew T., Hitman, Graham A., Hunt, Sarah E., Knowler, William C., Mitchell, Braxton D., Ng, Maggie C.Y., OʼConnell, Jeffrey R., Pollin, Toni I., Vaxillaire, Martine, Walker, Mark, Wang, Xiaoqin, Whittaker, Pamela, Kunsun, Xiang, Jia, Weiping, Chan, Juliana C. N., Froguel, Philippe, Deloukas, Panos, Shuldiner, Alan R., Elbein, Steven C., and McCarthy, Mark I.

Published
2006

174. Periodontal Disease and Mortality in Type 2 Diabetes

Author

Saremi, Aramesh, Nelson, Robert G., Tulloch-Reid, Marshall, Hanson, Robert L., Sievers, Maurice L., Taylor, George W., Shlossman, Marc, Bennett, Peter H., Genco, Robert, and Knowler, William C.

Published
2005

175. A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

Author

Bradfield, Jonathan P., Vogelezang, Suzanne, Felix, Janine F., Chesi, Alessandra, Helgeland, Oyvind, Horikoshi, Momoko, Karhunen, Ville, Lowry, Estelle, Cousminer, Diana L., Ahluwalia, Tarunveer S., Thiering, Elisabeth, Boh, Eileen Tai-Hui, Zafarmand, Mohammad H., Vilor-Tejedor, Natalia, Wang, Carol A., Joro, Raimo, Chen, Zhanghua, Gauderman, William J., Pitkanen, Niina, Parra, Esteban J., Fernandez-Rhodes, Lindsay, Alyass, Akram, Monnereau, Claire, Curtin, John A., Have, Christian T., McCormack, Shana E., Hollensted, Mette, Frithioff-Bojsoe, Christine, Valladares-Salgado, Adan, Peralta-Romero, Jesus, Teo, Yik-Ying, Standl, Marie, Leinonen, Jaakko T., Holm, Jens-Christian, Peters, Triinu, Vioque, Jesus, Vrijheid, Martine, Simpson, Angela, Custovic, Adnan, Vaudel, Marc, Canouil, Mickael, Lindi, Virpi, Atalay, Mustafa, Kahonen, Mika, Raitakari, Olli T., van Schaik, Barbera D. C., Berkowitz, Robert, I, Cole, Shelley A., Voruganti, V. Saroja, Wang, Yujie, Highland, Heather M., Comuzzie, Anthony G., Butte, Nancy F., Justice, Anne E., Gahagan, Sheila, Blanco, Estela, Lehtimaki, Terho, Lakka, Timo A., Hebebrand, Johannes, Bonnefond, Amelie, Grarup, Niels, Froguel, Philippe, Lyytikainen, Leo-Pekka, Cruz, Miguel, Kobes, Sayuko, Hanson, Robert L., Zemel, Babette S., Hinney, Anke, Teo, Koon K., Meyre, David, North, Kari E., Gilliland, Frank D., Bisgaard, Hans, Bustamante, Mariona, Bønnelykke, Klaus, Pennell, Craig E., Rivadeneira, Fernando, Uitterlinden, Andre G., Baier, Leslie J., Vrijkotte, Tanja G. M., Heinrich, Joachim, Sorensen, Thorkild I. A., Saw, Seang-Mei, Pedersen, Oluf, Hansen, Torben, Eriksson, Johan, Widen, Elisabeth, McCarthy, Mark, I, Njolstad, Pal R., Power, Christine, Hypponen, Elina, Sebert, Sylvain, Brown, Christopher D., Jarvelin, Marjo-Riitta, Timpson, Nicholas J., Johansson, Stefan, Hakonarson, Hakon, Jaddoe, Vincent W. V., Grant, Struan F. A., Bradfield, Jonathan P., Vogelezang, Suzanne, Felix, Janine F., Chesi, Alessandra, Helgeland, Oyvind, Horikoshi, Momoko, Karhunen, Ville, Lowry, Estelle, Cousminer, Diana L., Ahluwalia, Tarunveer S., Thiering, Elisabeth, Boh, Eileen Tai-Hui, Zafarmand, Mohammad H., Vilor-Tejedor, Natalia, Wang, Carol A., Joro, Raimo, Chen, Zhanghua, Gauderman, William J., Pitkanen, Niina, Parra, Esteban J., Fernandez-Rhodes, Lindsay, Alyass, Akram, Monnereau, Claire, Curtin, John A., Have, Christian T., McCormack, Shana E., Hollensted, Mette, Frithioff-Bojsoe, Christine, Valladares-Salgado, Adan, Peralta-Romero, Jesus, Teo, Yik-Ying, Standl, Marie, Leinonen, Jaakko T., Holm, Jens-Christian, Peters, Triinu, Vioque, Jesus, Vrijheid, Martine, Simpson, Angela, Custovic, Adnan, Vaudel, Marc, Canouil, Mickael, Lindi, Virpi, Atalay, Mustafa, Kahonen, Mika, Raitakari, Olli T., van Schaik, Barbera D. C., Berkowitz, Robert, I, Cole, Shelley A., Voruganti, V. Saroja, Wang, Yujie, Highland, Heather M., Comuzzie, Anthony G., Butte, Nancy F., Justice, Anne E., Gahagan, Sheila, Blanco, Estela, Lehtimaki, Terho, Lakka, Timo A., Hebebrand, Johannes, Bonnefond, Amelie, Grarup, Niels, Froguel, Philippe, Lyytikainen, Leo-Pekka, Cruz, Miguel, Kobes, Sayuko, Hanson, Robert L., Zemel, Babette S., Hinney, Anke, Teo, Koon K., Meyre, David, North, Kari E., Gilliland, Frank D., Bisgaard, Hans, Bustamante, Mariona, Bønnelykke, Klaus, Pennell, Craig E., Rivadeneira, Fernando, Uitterlinden, Andre G., Baier, Leslie J., Vrijkotte, Tanja G. M., Heinrich, Joachim, Sorensen, Thorkild I. A., Saw, Seang-Mei, Pedersen, Oluf, Hansen, Torben, Eriksson, Johan, Widen, Elisabeth, McCarthy, Mark, I, Njolstad, Pal R., Power, Christine, Hypponen, Elina, Sebert, Sylvain, Brown, Christopher D., Jarvelin, Marjo-Riitta, Timpson, Nicholas J., Johansson, Stefan, Hakonarson, Hakon, Jaddoe, Vincent W. V., and Grant, Struan F. A.

Published
2019

177. Variants in hepatocyte nuclear factor 4α are modestly associated with type 2 diabetes in Pima Indians

Author

Muller, Yunhua Li, Infante, Aniello M., Hanson, Robert L., Love-Gregory, Latisha, Knowler, William, Bogardus, Clifton, and Baier, Leslie J.

Subjects
World Health Organization -- Services, Type 2 diabetes -- Risk factors -- Diagnosis -- Care and treatment, Health, Diagnosis, Care and treatment, Risk factors, Services
Abstract

Single nucleotide polymorphisms (SNPs) within the hepatocyte nuclear factor 4α (HNF4α) gene are associated with type 2 diabetes in Finns and Ashkenazi Jews. Previous studies in both populations have reported linkage to type 2 diabetes near the HNF4α locus on chromosome 20q12-13. To investigate whether HNF4α is a diabetes susceptibility gene in Pima Indians, a population with the highest reported prevalence of type 2 diabetes but with no evidence for linkage of the disease on chromosome 20q, 19 SNPs across the promoter and coding region of HNF4α were genotyped for association analysis. In a group of 1,037 Pima Indians (573 diabetic and 464 nondiabetic subjects), three SNPs in HNF4α (rs3212183 and rs2071197 located in introns 3 and 1, respectively, and rs6031558, an extremely rare SNP located in the P2 promoter region) were modestly associated with type 2 diabetes (rs3212183 odds ratio [OR] 1.34 [95% CI 1.07-1.67], P = 0.009; rs2071197 1.34 [1.07-1.66], P = 0.008; and rs6031558 3.18 [1.03-9.84], P = 0.04, adjusted for age, sex, birth year, heritage, and family membership). We conclude that variants in HNF4α do not appear to be major determinants for type 2 diabetes in Pima Indians; however, HNF4α may have a minor role in type 2 diabetes susceptibility within this Native American population., Hepatocyte nuclear factor 4α (HNF4α) is a transcription factor expressed in many tissues including liver and pancreas (1). Its expression is controlled by two alternative promoters, P1 and P2, which [...]

Published
2005

183. Common polymorphisms in the adiponectin gene ACDC are not associated with diabetes in Pima Indians

Author

de Courten, Barbora Vozarova, Hanson, Robert L., Funahashi, Tohru, Lindsay, Robert S., Matsuzawa, Yuji, Tanaka, Sachiyo, Thameem, Farook, Gruber, Jonathan D., Froguel, Philippe, and Wolford, Johanna K.

Subjects
Type 2 diabetes -- Genetic aspects, Type 2 diabetes -- Risk factors, Adipose tissues -- Physiological aspects, Pimas -- Health aspects, Health
Abstract

Adiponectin is an abundant adipose tissue-derived protein with important metabolic effects. Plasma adiponectin levels are decreased in obese individuals, and low adiponectin levels predict insulin resistance and type 2 diabetes. Two variants in the adiponectin gene ACDC have been previously associated with plasma adiponectin levels, obesity, insulin resistance, and type 2 diabetes. To determine the role of genetic variation in ACDC in susceptibility to obesity and type 2 diabetes in Pima Indians, we screened the promoter, exons, and exon-intron boundaries of the gene to identify allelic variants. We identified 17 informative polymorphisms that comprised four common (minor allele frequency > 15%) linkage disequilibrium clusters consisting of 1-4 variants each. We genotyped one representative polymorphism from each cluster in 1,338 individuals and assessed genotypic association with type 2 diabetes, BMI, serum lipid levels, serum adiponectin levels, and measures of insulin sensitivity and secretion. None of the ACDC variants were associated with type 2 diabetes, BMI, or measures of insulin sensitivity or secretion. One variant, single nucleotide polymorphism (SNP)-12823, was associated with serum adiponectin levels (P = 0.002), but this association explained only 2% of the variance of serum adiponectin levels. Our findings suggest that these common ACDC polymorphisms do not play a major role in susceptibility to obesity or type 2 diabetes in this population., Adiponectin is an adipose tissue--derived protein with important metabolic effects (1). Plasma adiponectin levels are decreased in individuals with obesity (2), insulin resistance (3), and type 2 diabetes (2), and [...]

Published
2005

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