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630 results on '"Hanna, Nader"'

151. Abstract 4789: A novel MIF signaling pathway drives the malignant character of pancreatic cancer by targeting NR3C2

Author

Yang, Shouhui, primary, He, Peijun, additional, Wang, Liming, additional, Wang, Jian, additional, Schetter, Aaron, additional, Tang, Wei, additional, Funamizu, Naotake, additional, Yanaga, Katsuhiko, additional, Uwagawa, Tadashi, additional, Satoskar, Abhay R., additional, Gaedcke, Jochen, additional, Bernhardt, Markus, additional, Ghadimi, B. Michael, additional, Gaida, Matthias M, additional, Bergmann, Frank, additional, Werner, Jens, additional, Ried, Thomas, additional, Hanna, Nader, additional, Alexander, H. Richard, additional, and Hussain, S. Perwez, additional

Published
2017
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152. Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a Negative Regulator of Disease Aggressiveness in Pancreatic Cancer

Author

Wang, Jian, primary, Yang, Shouhui, additional, He, Peijun, additional, Schetter, Aaron J., additional, Gaedcke, Jochen, additional, Ghadimi, B. Michael, additional, Ried, Thomas, additional, Yfantis, Harris G., additional, Lee, Dong H., additional, Gaida, Matthias M., additional, Hanna, Nader, additional, Alexander, H. Richard, additional, and Hussain, S. Perwez, additional

Published
2016
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153. Abstract B34: A Novel MIF-driven Signaling Drives Disease Aggressiveness by Targeting NR3C2 in Pancreatic Cancer

Author

Yang, Shouhui, primary, He, Peijun, additional, Wang, Jian, additional, Schetter, Aaron, additional, Tang, Wei, additional, Funamizu, Naotake, additional, Yanaga, Katsuhiko, additional, Uwagawa, Tadashi, additional, Satoskar, Abhay R., additional, Gaedcke, Jochen, additional, Bernhardt, Markus, additional, Ghadimi, B. Michael, additional, Gaida, Matthias M., additional, Bergmann, Frank, additional, Werner, Jens, additional, Ried, Thomas, additional, Hanna, Nader, additional, Alexander, H. Richard, additional, and Hussain, S. Perwez, additional

Published
2016
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154. Abstract 2301: Intraperitoneal CAR-T infusion results in durable protection against peritoneal metastases and control of systemic tumor growth

Author

Cunetta, Marissa, primary, Point, Gary, additional, Liu, Zhi, additional, Guha, Prajna, additional, Darpolor, Josephine, additional, Lima, Matthew, additional, Espat, N J., additional, Hanna, Nader, additional, Boutros, Cherif, additional, Junghans, Richard P., additional, and Katz, Steven, additional

Published
2016
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155. A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2

Author

Yang, Shouhui, primary, He, Peijun, additional, Wang, Jian, additional, Schetter, Aaron, additional, Tang, Wei, additional, Funamizu, Naotake, additional, Yanaga, Katsuhiko, additional, Uwagawa, Tadashi, additional, Satoskar, Abhay R., additional, Gaedcke, Jochen, additional, Bernhardt, Markus, additional, Ghadimi, B. Michael, additional, Gaida, Matthias M., additional, Bergmann, Frank, additional, Werner, Jens, additional, Ried, Thomas, additional, Hanna, Nader, additional, Alexander, H. Richard, additional, and Hussain, S. Perwez, additional

Published
2016
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156. Inducible nitric oxide synthase enhances disease aggressiveness in pancreatic cancer

Author

Wang, Jian, primary, He, Peijun, additional, Gaida, Matthias, additional, Yang, Shouhui, additional, Schetter, Aaron J., additional, Gaedcke, Jochen, additional, Ghadimi, B. Michael, additional, Ried, Thomas, additional, Yfantis, Harris, additional, Lee, Dong, additional, Weiss, Jonathan M., additional, Stauffer, Jimmy, additional, Hanna, Nader, additional, Alexander, H. Richard, additional, and Hussain, S. Perwez, additional

Published
2016
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159. The Chicago Consensus Guidelines for peritoneal surface malignancies: Introduction.

Author

Turaga, Kiran, Ahuja, Nita, Richard Alexander, H., Abbott, Daniel E., Badgwell, Brian, Baumgartner, Joel M., Choudry, M. Haroon A., Cusack, James C., Deneve, Jeremiah L., Esquivel, Jesus, Foster, Jason M., Hanna, Nader, Hayes‐Jordan, Andrea, Johnston, Fabian M., Labow, Daniel M., Lambert, Laura A., Lee, Byrne, Levine, Edward A., Lowy, Andrew M., and Nash, Garrett M.

Subjects
CANCER, GUIDELINES, PALLIATIVE treatment, PATHOLOGISTS, ONCOLOGISTS, COMPARATIVE studies, RESEARCH methodology, MEDICAL cooperation, MEDICAL protocols, RESEARCH, PERITONEUM tumors, EVALUATION research
Abstract

The Chicago Consensus Working Group provides multidisciplinary recommendations for the management of peritoneal surface malignancies of various causes. These guidelines are developed with input from leading experts including surgical oncologists, medical oncologists, pathologists, radiologists, palliative care physicians, and pharmacists. These guidelines recognize and address the emerging need for increased awareness of the appropriate management of peritoneal surface disease. They are not intended to replace the quest for higher levels of evidence. This article serves as an introduction to this effort. [ABSTRACT FROM AUTHOR]

Published
2020
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161. SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer.

Author

Ohara, Yuuki, Tang, Wei, Liu, Huaitian, Yang, Shouhui, Dorsey, Tiffany H., Cawley, Helen, Moreno, Paloma, Chari, Raj, Guest, Mary R., Azizian, Azadeh, Gaedcke, Jochen, Ghadimi, Michael, Hanna, Nader, Ambs, Stefan, and Hussain, S. Perwez

Abstract

Pancreatic ductal adenocarcinoma (PDAC) exhibits distinct molecular subtypes: classical/progenitor and basal-like/squamous. Our study aimed to identify genes contributing to the development of the basal-like/squamous subtype, known for its aggressiveness. Transcriptome analyses revealed consistent upregulation of SERPINB3 in basal-like/squamous PDAC, correlating with reduced patient survival. SERPINB3 transgene expression in PDAC cells enhanced in vitro invasion and promoted lung metastasis in a mouse PDAC xenograft model. Metabolome analyses unveiled a metabolic signature linked to both SERPINB3 and the basal-like/squamous subtype, characterized by heightened carnitine/acylcarnitine and amino acid metabolism, associated with poor prognosis in patients with PDAC and elevated cellular invasiveness. Further analysis uncovered that SERPINB3 inhibited the cysteine protease calpain, a key enzyme in the MYC degradation pathway, and drove basal-like/squamous subtype and associated metabolic reprogramming through MYC activation. Our findings indicate that the SERPINB3-MYC axis induces the basal-like/squamous subtype, proposing SERPINB3 as a potential diagnostic and therapeutic target for this variant. [Display omitted] • SERPINB3 is linked to poor patient survival in pancreatic ductal adenocarcinoma (PDAC) • SERPINB3 enhances tumor metastasis in an orthotopic preclinical PDAC mouse model • SERPINB3-MYC axis induces the aggressive basal-like/squamous molecular subtype • SERPINB3-MYC axis increases carnitine/acylcarnitine and amino acid metabolism Ohara et al. use a comprehensive transcriptome and metabolome analysis to show that the SERPINB3-MYC axis drives the aggressive basal-like/squamous molecular subtype in pancreatic ductal adenocarcinoma. This axis also promotes subtype-associated metabolic alterations, including heightened carnitine/acylcarnitine and amino acid metabolism, correlating with poorer patient prognosis. [ABSTRACT FROM AUTHOR]

Published
2023
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173. Exploring the influence of a human-like dancing virtual character on the evocation of human emotion.

Author

Roxas, Jon Cedric, Richards, Deborah, Bilgin, Ayse, and Hanna, Nader

Subjects
ANALYSIS of variance, ANGER, DANCE, EMOTIONS, EXPERIMENTAL design, HAPPINESS, PROBABILITY theory, QUESTIONNAIRES, SCALE analysis (Psychology), VIRTUAL reality, DESCRIPTIVE statistics
Abstract

Dance has universally been used as a form of human expression for thousands of years. This common human behaviour and communication method has not been explored much in the context of computer-based technology, even within the field of virtual human research. This paper presents an experimental study investigating the impact of watching dancing virtual characters on human emotions. The study analysed the responses of 55 participants, composed of a mix of dancers and non-dancers, who watched a dancing virtual character perform 3 different dances that represented anger, sadness and happiness in different display orders. The participants’ reported changes in their emotions and their feelings of anger, sadness and happiness were significantly dependent on which dancing character’s emotion they watched and the emotional change did not rely on correct recognition of the depicted emotion. For experimental control, our characters were faceless and danced without music. Our results suggest that just by watching a dancing virtual character some of the benefits associated with dancing could be accessed in circumstances where it is not desirable or feasible to dance, justifying further research to develop a personalised character with a face and music that adapts according to the humans’ emotions and preferences. [ABSTRACT FROM PUBLISHER]

Published
2018
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174. Preoperative Thrombocytosis Predicts Shortened Survival in Patients with Malignant Peritoneal Mesothelioma Undergoing Operative Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy.

Author

Li, Yue, Khashab, Tamara, Terhune, Julia, Eckert, Richard, Hanna, Nader, Burke, Allen, and Richard Alexander, H.

Abstract

Background: This study was designed to determine the clinical significance of preoperative thrombocytosis in patients with malignant peritoneal mesothelioma (MPM) undergoing operative cytoreduction (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). CRS and HIPEC have been associated with prolonged survival in patients with MPM and is the preferred treatment in select patients. However, patient selection criteria remain ill-defined for this operation that is also associated with significant morbidity and mortality. Preoperative thrombocytosis has been associated with poor outcomes in various malignancies but never studied in MPM. Methods: Between January 2006 and December 2015, 100 patients with high-grade epithelioid MPM were evaluated and selected for CRS and HIPEC at our center (M: 53, F: 47; mean age: 54 years [range 17-81 years]). We analyzed various patient and treatment related factors potentially associated with overall survival (OS). Results: The median actuarial overall survival was 32.8 months; the actuarial 1-, 3-, 5-year survivals were 70, 49, and 36%, respectively. On multivariate analysis, suboptimal resection (CCR > 1), high tumor burden (PCI > 20), and elevated preoperative platelet count (>367,000/mm) were independently associated with shortened OS ( P < 0.05). Median OS in patients with elevated versus normal platelet counts were 13 and 58 months, respectively ( P < 0.001). Compared with patients with normal platelet counts, patients with elevated counts had significantly greater residual disease after operation ( P = 0.008). Conclusions: Elevated preoperative platelet count is independently associated with poor outcome. Notably, thrombocytosis reflects aggressive tumor biology and should be considered a factor in patient selection for CRS and HIPEC. [ABSTRACT FROM AUTHOR]

Published
2017
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181. Abstract 926: Nitric oxide enhances tumor progression and disease aggressiveness in pancreatic cancer

Author

Wang, Jian, primary, He, Peijun, additional, Gaida, Matthias M., additional, Yang, Shouhui, additional, Schetter, Aaron, additional, Gaedcke, Jochen, additional, Ghadimi, Michael, additional, Ried, Thomas, additional, Yfantis, Harris G., additional, Lee, Dong H., additional, Weiss, Jonathan M., additional, Stauffer, Jim, additional, Hanna, Nader, additional, Alexander, H. Richard, additional, and Hussain, S. Perwez, additional

Published
2014
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182. Abstract 4363: Macrophage migration inhibitory factor (MIF) and miR-301b interactively enhance disease aggressiveness by targeting NR3C2 in human pancreatic cancer

Author

Yang, Shouhui, primary, He, Peijun, additional, Wang, Jian, additional, Schetter, Aaron, additional, Funamizu, Naotake, additional, Yanaga, Katsuhiko, additional, Gaedcke, Jochen, additional, Ghadimi, B. Michael, additional, Gaida, Matthias M., additional, Ried, Thomas, additional, Hanna, Nader, additional, Alexander, H. Richard, additional, and Hussain, S. Perwez, additional

Published
2014
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192. Integration of Metabolomics and Transcriptomics Revealed a Fatty Acid Network Exerting Growth Inhibitory Effects in Human Pancreatic Cancer

Author

Zhang, Geng, primary, He, Peijun, additional, Tan, Hanson, additional, Budhu, Anuradha, additional, Gaedcke, Jochen, additional, Ghadimi, B. Michael, additional, Ried, Thomas, additional, Yfantis, Harris G., additional, Lee, Dong H., additional, Maitra, Anirban, additional, Hanna, Nader, additional, Alexander, H. Richard, additional, and Hussain, S. Perwez, additional

Published
2013
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194. Neoadjuvant Chemoradiation for Distal Rectal Cancer: 5-Year Updated Results of a Randomized Phase 2 Study of Neoadjuvant Combined Modality Chemoradiation for Distal Rectal Cancer

Author

Mohiuddin, Mohammed, primary, Paulus, Rebecca, additional, Mitchell, Edith, additional, Hanna, Nader, additional, Yuen, Albert, additional, Nichols, Romaine, additional, Yalavarthi, Salochna, additional, Hayostek, Cherie, additional, and Willett, Christopher, additional

Published
2013
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200. Patterns of Biologics Use Across Treatment Lines in Elderly (Age >65) Medicare Patients With Metastatic Colon Cancer.

Author

Bikov, Kaloyan A., Mullins, C. Daniel, Hung, Anna, Seal, Brian, Onukwugha, Eberechukwu, and Hanna, Nader

Subjects
BIOLOGICAL products, CANCER chemotherapy, COLON tumors, CONFIDENCE intervals, STATISTICAL correlation, DRUG prescribing, MEDICARE, MULTIVARIATE analysis, PROBABILITY theory, RESEARCH funding, STATISTICS, PHYSICIAN practice patterns, MULTIPLE regression analysis, SECONDARY analysis, BEVACIZUMAB, DATA analysis software, DESCRIPTIVE statistics, ODDS ratio, OLD age
Abstract

Background. We explored biologics receipt in metastatic colon cancer. Methods. We used Surveillance, Epidemiology, and End Results-Medicare data of 4,545 elderly patients diagnosed with incident metastatic colon cancer from 2003 to 2009, treated with chemotherapy and/or biologics, and followed up through 2010. Results. A total of 2,504 (55%) patients received a biologics-containing regimen. Treatment with biologics fluctuated between 46% and 63% of first-line regimens and 67% and 73% of second-line regimens. Bevacizumab accounted for 95% of first-line and 68% of second-line biologics use. Cetuximab accounted for 33% of second-line and 48% of third-line use. Panitumumab accounted for 5% of second-line and 27% of third-line use. The adjusted odds of biologics receipt decreased rapidly with age, resulting in a threefold difference between the youngest and the oldest study participants in the sample (odds ratio [OR] 0.35, p < .01). African Americans (OR 0.77, p = .03) and patients with Charlson Comorbidity Index of 1(OR 0.83, p =.02) or >1 (OR 0.75, p < .01) were considerably less likely to receive biologics therapy. Medicare state buy-in was associated with 2% lower odds of receiving biologics (OR 0.98, p = .04). Conclusion. After controlling for sociodemographic and clinical differences, age, race, comorbidities, and low income had a statistically significantly negative effect on the likelihood of receiving biologics among treated patients. Use of biologics varied over time, across the treatment continuum, and by chemotherapy regimen. Bevacizumab was most frequently used in both first- and second-line treatment. Cetuximab was the second most prescribed biologic. Panitumumab use was mostly limited to third-line treatment. [ABSTRACT FROM AUTHOR]

Published
2016
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