416 results on '"Hangyu Li"'
Search Results
152. Constitutive Relation of Fiber Reinforced Concrete under Uniaxial Compression
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Tian Xiao, Ma Xiaoxia, Chen Shengping, Hangyu Li, and Liang Ni
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Materials science ,Constitutive equation ,Uniaxial compression ,Fiber-reinforced concrete ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials ,law.invention ,Hydrostatic test ,Control and Systems Engineering ,law ,Materials Chemistry ,Ceramics and Composites ,Cylinder ,Electrical and Electronic Engineering ,Composite material ,Servo - Abstract
The uniaxial compressive experiment of steel fiber reinforced concrete cylinder was carried out by microcomputer controlled electro-hydraulic servo pressure testing machine, which studied the effec...
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- 2021
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153. BTN3A1 expressed in cervical cancer cells promotes Vγ9Vδ2 T cells exhaustion through upregulating transcription factors NR4A2/3 downstream of TCR signaling
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Jian Liu, Min Wu, Yifan Yang, Xinyu Mei, Liming Wang, Jingyu Wang, Zixuan Wang, Shan He, Hangyu Liu, Han Jiang, Shen Qu, Yuwei Zhang, Ying Chen, Xun Tian, Yafei Huang, and Hui Wang
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BTN3A1 ,Cervical cancer ,Tumor microenvironment ,Adoptive T-cell therapy ,Vγ9Vδ2 T cells ,NR4A ,Medicine ,Cytology ,QH573-671 - Abstract
Abstract Background Clinical trials have shown that immunotherapy based on Vγ9Vδ2 T cells (Vδ2 T cells) is safe and well-tolerated for various cancers including cervical cancer (CC), but its overall treatment efficacy remains limited. Therefore, exploring the mechanisms underlying the suboptimal efficacy of Vδ2 T cell-based cancer immunotherapy is crucial for enabling its successful clinical translation. Methods Tumor samples from CC patients and CC cell line-derived xenograft (CDX) mice were analyzed using flow cytometry to examine the exhausted phenotype of tumor-infiltrating Vδ2 T cells. The interrelationship between BTN3A1 expression and Vδ2 T cells in CC, along with their correlation with patient prognosis, was analyzed using data from The Cancer Genome Atlas (TCGA) database. CC cell lines with BTN3A1 knockout (KO) and overexpression (OE) were constructed through lentivirus transduction, which were then co-cultured with expanded Vδ2 T cells, followed by detecting the function of Vδ2 T cells using flow cytometry. The pathways and transcription factors (TFs) related to BTN3A1-induced Vδ2 T cells exhaustion and the factors affecting BTN3A1 expression were identified by RNA-seq analysis, which was confirmed by flow cytometry, Western Blot, and gene manipulation. Results Tumor-infiltrating Vδ2 T cells exhibited an exhausted phenotype in both CC patients and CDX mice. BTN3A1 expressed in CC is highly enhancing exhaustion markers, while reducing the secretion of effector molecules in Vδ2 T cells. Blocking TCR or knocking down nuclear receptor subfamily 4 group A (NR4A) 2/3 can reverse BTN3A1-induced exhaustion in Vδ2 T cells. On the other hand, IFN-γ secreted by Vδ2 T cells promoted the expression of BTN3A1 and PD-L1. Conclusions Through binding γδ TCRs, BTN3A1 expressed on tumor cells, which is induced by IFN-γ, can promote Vδ2 T cells to upregulate the expression of TFs NR4A2/3, thereby affecting their activation and expression of exhaustion-related molecules in the tumor microenvironment (TME). Therefore, targeting BTN3A1 might overcome the immunosuppressive effect of the TME on Vδ2 T cells in CC.
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- 2024
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154. Geothermal development associated with enhanced hydrocarbon recovery and geological CO2 storage in oil and gas fields in Canada
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Kai Zhang, Shu Jiang, Zhangxin Chen, Hangyu Li, and Shuyang Liu
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Fuel Technology ,Nuclear Energy and Engineering ,Renewable Energy, Sustainability and the Environment ,Energy Engineering and Power Technology - Published
- 2023
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155. Dynamic stiffness of polyester fiber mooring ropes: Experimental investigation based on radial basis function neural networks
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He Zhang, Ji Zeng, Shukang Tong, Bowen Jin, Chiate Chou, Hangyu Li, and Hailei Dong
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Environmental Engineering ,Ocean Engineering - Published
- 2023
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156. Risk evaluation of CO2 leakage through fracture zone in geological storage reservoir
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Zhiqiang Wang, Hangyu Li, Shuyang Liu, Jianchun Xu, Junrong Liu, and Xiaopu Wang
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Fuel Technology ,General Chemical Engineering ,Organic Chemistry ,Energy Engineering and Power Technology - Published
- 2023
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157. Enhancement of the immune response via the facilitation of dendritic cell maturation by CD-205 Receptor-mediated Long-circling liposomes acting as an antigen and astragalus polysaccharide delivery system
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Qianqian Liu, Xinnan Zhang, Dongkun Chai, Hangyu Li, Sheng Li, Daiyan Wu, Linzi Zhang, Ziwei Liu, Yangyang Feng, Feng Tang, and Haibo Feng
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Pharmacology ,Immunology ,Immunology and Allergy - Published
- 2023
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158. Aptamer based biosensor platforms for neurotransmitters analysis
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Ziheng Hu, Yaqi Li, Gabriela Figueroa-Miranda, Simon Musall, Hangyu Li, Mateo Alejandro Martínez-Roque, Qinyu Hu, Lingyan Feng, Dirk Mayer, and Andreas Offenhäusser
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Spectroscopy ,Analytical Chemistry - Published
- 2023
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159. Machine learning assisted two-phase upscaling for large-scale oil-water system
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Yanji Wang, Hangyu Li, Jianchun Xu, Shuyang Liu, Qizhi Tan, and Xiaopu Wang
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General Energy ,Mechanical Engineering ,Building and Construction ,Management, Monitoring, Policy and Law - Published
- 2023
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160. Multimodal bubble microrobot near free liquid surface
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Leilei Wang, Li Chen, Xu Zheng, Zexiong Yu, Wenchao Lv, Minjia Sheng, Lina Wang, Pengcheng Nie, Hangyu Li, Dongshi Guan, and Haihang CUI
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The development of multifunctional and robust swimming microrobots working at the free air-liquid interface has encountered challenge as new manipulation strategy are needed to overcome the complicated interfacial restrictions. Here, we show flexible but reliable mechanisms to achieve a remote-control bubble microrobot with multiple working modes and high maneuverability by the assistance of a soft air-liquid interface. This bubble microrobot is developed from a hollow Janus microsphere regulated by a magnetic field, which can implement switchable working modes like pusher, gripper, anchor and sweeper. The cavitation of the microbubble and the accompanying directional jet flow play a key role for functioning in these working modes, which is analogues to "bubble tentacle". In particular, we find a novel speed modulation method for the bubble microrobot that does not need to change the fuel concentration. Our findings demonstrate a substantial advance of the bubble microrobot specifically working at the air-liquid interface. And the results depict the nonintuitive mechanisms, such as bubble dynamics confined by a free surface, hydrodynamic jetting and surface capillary wave induced by bubble collapse, and bubble particle interaction, which offer helpful insights for developing swimming microrobots working in complicated environments.
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- 2022
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161. DEC-205 receptor targeted poly(lactic-co-glycolic acid) nanoparticles containing Eucommia ulmoides polysaccharide enhances the immune response of foot-and-mouth disease vaccine in mice
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Yangyang Feng, Jing Fan, Daiyan Wu, Qianqian Liu, Hangyu Li, Xinnan Zhang, Sheng Li, Feng Tang, Ziwei Liu, Linzi Zhang, and Haibo Feng
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Structural Biology ,General Medicine ,Molecular Biology ,Biochemistry - Abstract
Nanoparticles targeting the DEC-205 receptor were found to induce antigen-specific protective immune response. When the delivery system carries both antigens and immunomodulators, it can maximize the expected therapeutic effect of the drug and induce effective humoral and cellular immune responses to antigens.In this study, we encapsulated the Eucommia ulmoides Oliv. polysaccharides (EUPS) into PLGA nanoparticles (NPs) and conjugated it with anti-CD205 monoclonal Ab (MAb) to produce a DEC-205 receptor targeted PLGA nanoparticles (anti-DEC-205-EUPS-PLGA NPs). The physicochemical characteristics and adjuvant activity of the above NPs were evaluated in vitro and in vivo. In the in vitro setting, 200 μg·mL
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- 2022
162. Research on multi-energy coupled preheating system of city gate station based on Modelica simulation
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Hangyu Liu, Zhicong Fang, Xianying Hao, Zhiguang Chen, Hui Zhang, and Jianguo Feng
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City gate station ,Preheating systems ,Modelica dynamic simulation ,Multi-energy coupling ,Performance evaluation ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Natural gas depressurization at city gate stations can cause hydrate formation, necessitating preheating before pressure regulation. To reduce the high energy consumption of traditional city gate station preheating processes, this study introduces four novel multi-energy coupled systems: photovoltaic-air source heat pump (PV-ASHP), solar thermal-combined heat and power-ASHP (ST-CHP-ASHP), CHP-ASHP, and ASHP system, with a typical city gate station in Shanghai taken as the research case. Dynamic energy simulation systems were developed in Dymola software to evaluate the proposed systems from energy, environmental, and economic perspectives, conducting a comparison with conventional boiler preheating systems, including sensitivity analysis of energy prices on system economics. Results indicate PV-ASHP has the lowest annual total cost (ATC) and shortest discounted payback period, while ATC values for ST-CHP-ASHP, CHP-ASHP, and ASHP increase by 6.4 %, 9.6 %, and 12.6 %, respectively. ST-CHP-ASHP and PV-ASHP demonstrate advantages in primary energy rate and carbon emissions, with ST-CHP-ASHP performing slightly better than PV-ASHP. Currently, PV-ASHP demonstrates the highest development potential. If photovoltaic feed-in tariffs remain constant, and natural gas prices decrease by over 12.5 % or CHP feed-in tariffs increase by over 38.4 %, ST-CHP-ASHP becomes more economically viable. This research provides valuable insights for retrofitting China's existing city gate station preheating systems.
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- 2024
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163. Stretchable and Shelf-Stable All-Polymer Supercapacitors Based on Sealed Conductive Hydrogels
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Qing Chen, Mei Wang, Hangyu Li, Ning Zhang, and Mingming Ma
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Supercapacitor ,chemistry.chemical_classification ,Conductive polymer ,Materials science ,Energy Engineering and Power Technology ,Nanotechnology ,Polymer ,Electroactive materials ,chemistry.chemical_compound ,chemistry ,Self-healing hydrogels ,Polyaniline ,Materials Chemistry ,Electrochemistry ,Chemical Engineering (miscellaneous) ,Electrical and Electronic Engineering ,Electrical conductor - Abstract
The emerging stretchable supercapacitor (SSC) is the key component in stretchable electronic devices. Most of the current SSCs require elastic substrates to load electroactive materials, which limi...
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- 2020
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164. Investigation of Arc Erosion Mechanism for Tin Dioxide-Reinforced Silver-Based Electrical Contact Material Under Direct Current
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Hangyu Li, Yanfeng Liu, Xianhui Wang, and Zhudong Hu
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010302 applied physics ,Materials science ,Direct current ,Evaporation ,chemistry.chemical_element ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Cathode ,Electrical contacts ,Electronic, Optical and Magnetic Materials ,Anode ,law.invention ,Arc (geometry) ,chemistry ,law ,0103 physical sciences ,Electrode ,Materials Chemistry ,Electrical and Electronic Engineering ,Composite material ,0210 nano-technology ,Tin - Abstract
To get an in-depth insight into the arc erosion mechanism for tin dioxide-reinforced silver-based (Ag-SnO2) contact material, the contact pairs made of Ag-4wt%SnO2 contact material were, respectively, performed for 20,000 switching operations under the direct currents of 19 A and 29 A and the voltage of 12 V, together with the electrode gap of 4 mm. The eroded surfaces and cross-sectional morphologies and the chemical compositions were characterized by scanning electron microscopy equipped with an energy dispersive spectrometer (EDS). The results show that there is a deep erosion pit at the cathode and an apparent protrusion at the anode, suggesting that a serious material transfer generates from cathode to anode. The EDS results show that the Sn contents at the protrusion and at the region around the crater are below 0.75 wt.% and 4 wt.%, respectively. This reveals that SnO2 undergoes severe evaporation during electrical contact testing. Moreover, arc stability decreases with increasing the load current, and the Ag-SnO2 contact material has larger arc power (make arc: 68.2 J/s; break arc: 58.53 J/s at 29 A) as compared to Ag-TiB2 contact material (make arc: 62.85 J/s; break arc: 50.01 J/s at 29 A). As a result, it is thought that SnO2 evaporation reduces Ag dissipation, thus shortening the lasting time of the make arc. However, the emission current is increased owing to the low work function of SnO2, which further promotes the improvement in the density of the charged particles, thereby enhancing the arc power. Additionally, the large density of charged particles can sustain arc burning for a longer time, resulting in an extended break arc duration.
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- 2020
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165. YAP1 Inhibition in HUVECs Is Associated with Released Exosomes and Increased Hepatocarcinoma Invasion and Metastasis
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Qianqian Zheng, Xin Meng, Yan Li, Chen Zhu, Qi Wang, Yingbo Ma, Xiaodong Zhang, Xueqiang Peng, Hangyu Li, Yijun Zhang, Biao Wang, Liang Yang, and Jingang Liu
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0301 basic medicine ,Tube formation ,YAP1 ,Tumor microenvironment ,MALAT1 ,Angiogenesis ,business.industry ,lcsh:RM1-950 ,medicine.disease ,Microvesicles ,Article ,Metastasis ,03 medical and health sciences ,lcsh:Therapeutics. Pharmacology ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Drug Discovery ,Cancer research ,Hepatic stellate cell ,Molecular Medicine ,Medicine ,business - Abstract
Hepatocellular carcinoma is one of the most common gastrointestinal malignancies. Anti-angiogenesis therapies have recently demonstrated promise in the treatment of malignancies, although early treatment benefits may be accompanied by metastasis over time. Additional and more effective anti-angiogenic treatment modalities are therefore needed. We previously found that Yes-associated protein 1 (YAP1) expression is increased in hepatocellular carcinoma (HCC), particularly around tumor-associated blood vessels, suggesting a role in angiogenesis. The YAP1 inhibitor verteporfin is presently in anti-angiogenic clinical trials for the treatment of various cancers. Depleted YAP1 from vascular endothelial cells effectively reduced proliferation and tube formation, validating its utility as an anti-angiogenesis target. We also showed that YAP1 depletion or inhibition in vascular endothelial cells leads to increased release of exosomes containing the long non-coding RNA (lncRNA) MALAT1 into the tumor microenvironment. Direct exosomal transfer of MALAT1 to hepatic cells leads to increased hepatic cell invasion and migration via activation of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling. These observations may explain the occurrence of distant tumor metastasis with YAP1-associated anti-angiogenic therapy over time. It provides insight into new pathways and treatment paradigms that may be targeted to increase the long-term success of anti-angiogenic therapies., Graphical Abstract, YAP1 deficiency effectively inhibits angiogenesis and promotes the release of exosomes. Released exosomes promote the distant migration of HCC cells by activating the ERK1/2 pathway; accordingly, ERK1/2 inhibitors can reverse the metastasis-promoting effect of YAP1-KD. The combination of VP and ERK1/2 inhibitor may be an effective new approach for anti-angiogenesis therapy.
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- 2020
166. MicroRNA-375 Targets ATG14 to Inhibit Autophagy and Sensitize Hepatocellular Carcinoma Cells to Sorafenib
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Xinyu Li, Bowen Li, Shuo Yang, Yan Li, Yingbo Ma, Hangyu Li, Hongyuan Jin, Xueqiang Peng, Liang Yang, and Minggang Wang
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0301 basic medicine ,Sorafenib ,medicine.diagnostic_test ,Chemistry ,Autophagy ,medicine.disease ,digestive system diseases ,Flow cytometry ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Oncology ,Apoptosis ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Cancer cell ,medicine ,Cancer research ,Pharmacology (medical) ,MTT assay ,Viability assay ,neoplasms ,medicine.drug - Abstract
Purpose Sorafenib has revolutionized treatment of hepatocellular carcinoma (HCC), but its efficacy is limited by drug resistance. Autophagy is the process by which cellular components are transported to lysosomes for degradation, which promotes energy production and production of macromolecular precursors. Studies have suggested that the cytoprotective function of autophagy may contribute to chemoresistance or targeted drug resistance in cancer cells. We investigated the effects of miR-375 and autophagy-related protein 14, and their interrelationships, on sorafenib efficacy. Methods Cell viability was measured using the MTT assay, and apoptosis was evaluated using flow cytometry. Colony formation assay was performed to determine changes in cell number. Real-time PCR and Western blotting were performed to quantify the expression of key genes and proteins. Immunofluorescence and transmission electron microscopy were used to detect autophagy. Dual-luciferase reporter assays were used to verify a direct target. Results We characterized the relationship between sorafenib and autophagy. We showed that inhibition of autophagy enhanced sensitivity of HCC to sorafenib and showed that miR-375 was important in this process. Finally, we showed that miR-375 affected sensitivity of HCC cells to sorafenib through regulation of ATG14. Conclusion We showed that miR-375 sensitized HCC cells to sorafenib by blocking sorafenib-induced autophagy. We also showed that ATG14 was a direct autophagy-related target of miR-375. These findings indicated that miR-375-ATG14 was important in the development of sorafenib resistance in HCC.
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- 2020
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167. Tumor-derived exosomes in the cancer immune microenvironment and cancer immunotherapy
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Qiushi Tang, Shuo Yang, Guangpeng He, Hongyu Zheng, Sheng Zhang, Jiaxing Liu, Shibo Wei, Qing Fan, Xueqiang Peng, Xinyu Li, Dewei Zhang, Liang Yang, and Hangyu Li
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Cancer Research ,Dichlorodiphenyldichloroethane ,Oncology ,Neoplasms ,Tumor Microenvironment ,Humans ,Immunotherapy ,Exosomes - Abstract
Tumor-derived exosomes (TDEs) are key immune regulators in the tumor microenvironment. They have been shown to reshape the immune microenvironment and prevent antitumor immune responses via their immunosuppressive cargo, thereby determining responsiveness to cancer therapy. By delivering suppressive cargo to the immune cells, TDEs directly or indirectly influence the functions and antitumor activities of immune cells. TDE-based therapy is emerging as a cutting-edge and promising strategy for inhibiting tumor progression or enhancing antitumor immunity. Therefore, in this study, we reviewed the mechanism by which TDEs regulate immune cells and their applications in immunotherapy.
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- 2022
168. Hypoxia, a key factor in the immune microenvironment
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Jingyao Hu, Xinyu Li, Liang Yang, and Hangyu Li
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Pharmacology ,Neoplasms ,Tumor Microenvironment ,Humans ,Tumor Escape ,General Medicine ,Hypoxia ,Cell Hypoxia - Abstract
The physical and chemical pressures in the tumor microenvironment (TME) play an important role in tumor development by regulating stromal elements, including immune cells. Hypoxia can induce a cascade of events in tumor initiation and development via immune regulation. As a dangerous factor, hypoxia activates multiple signaling pathways to reshape the immune microenvironment, leading to immunosuppression. Consequently, targeting hypoxia in the TME is a potential strategy to prevent immune escape and inhibit malignant tumor progression. In this review, we summarized the role of hypoxia-induced factors in the tumor immune escape process and provide a novel pathway to restrain tumor progression and development.
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- 2022
169. Quasi-periodic scattering of topological edge states induced by the vacancies in chloridized gallium bismuthide nanoribbons
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Hangyu Li and Zhongyao Li
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General Materials Science ,Condensed Matter Physics - Abstract
The chloridized gallium bismuthide was predicted to be a two-dimensional topological insulator with large topological band gap. It may be beneficial for achieving the quantum spin Hall effect and its related applications at high temperatures. To better understand the quantum transport in topological nanoribbons, we investigated the effect of vacancy on the quantum transport of topological edge states in the armchair chloridized gallium bismuthide nanoribbons by combining density functional theory and nonequilibrium Green’s function. The results suggest the vacancies at center are more likely to cause the scattering of topological edge states. The average scattering is insensitive to the enlargement of vacancy along the transport direction. More interestingly, the obvious scattering of topological edge states can only be found at some special energies, and these special energies are distributed quasi-periodically. The quasi-periodic scattering may be used as a kind of fingerprint of vacancies. Our studies may be helpful for the application of topological nanoribbons.
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- 2023
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170. New insight into the activation mechanism of hydrogen peroxide by greigite (Fe3S4) for benzene removal: The combined action of dissolved and surface bounded ferrous iron
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Cong Liang, Linbo Qian, Hangyu Li, Xinzhu Dong, Tao Zheng, and Mengfang Chen
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Environmental Engineering ,Health, Toxicology and Mutagenesis ,Public Health, Environmental and Occupational Health ,Environmental Chemistry ,General Medicine ,General Chemistry ,Pollution - Published
- 2023
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171. Enhanced Cr(Ⅵ) reduction by zero-valent iron and ferroferric oxide wet ball milling: Synergy of electron storage and electron transfer
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Hangyu Li, Linbo Qian, Cong Liang, Tao Zheng, Xinzhu Dong, and Mengfang Chen
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General Chemical Engineering ,Environmental Chemistry ,General Chemistry ,Industrial and Manufacturing Engineering - Published
- 2023
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172. Pore-scale modeling of seepage behaviors and permeability evolution in heterogeneous hydrate-bearing sediments and its implications for the permeability model
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Jianchun Xu, Ziwei Bu, Huating Qin, Shuxia Li, and Hangyu Li
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- 2023
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173. Improved mechanical properties of Ni-rGO/Cu composites prepared by molecular-level mixing
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Jituo Liu, Xianhui Wang, Jia Liu, Hangyu Li, and Hongbo Zhang
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General Materials Science ,General Chemistry - Published
- 2022
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174. Low-Temperature Solution-Processed Bilayer Ingazno/In2o3 Thin Film Transistors Based on Lightwave Annealing
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Qian Zhang, Hangyu Li, Qiang Sun, Guodong Xia, Hongyu Gong, and Sumei Wang
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- 2022
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175. Enhanced Cr(Vi) Reduction by Zero-Valent Iron and Ferroferric Oxide Wet Ball Milling: Synergy of Electron Storage and Electron Transfer
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Hangyu Li, Linbo Qian, Cong Liang, Tao Zheng, Xinzhu Dong, and Mengfang Chen
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
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176. Three-Dimensional Deviation Analysis of High-Speed Spindle Assembly Based on Skin Model Shapes
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Ang Tian, Sun Jin, Kun Chen, Shun Liu, Hangyu Li, and Zhihua Niu
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The high-speed motorized spindle is the core component of the machine tool, and its assembly accuracy directly determines the quality of the processing product and the service life of the spindle itself. As a typical revolving components assembly, it is critical to ensure that the radial and axial runout performance of the assembly is extremely excellent to satisfy the requirements of high precision and rigidity. Meanwhile, geometric deviations are inevitably observable on manufactured components of spindle, especially the form deviations of revolving part have huge influences on the quality and function of spindle. However, geometric deviations are reduced to dimensional and orientation defects without considering form deviations in most previous models of deviation analysis. Skin Model Shape of a work piece is a discrete geometry representation of the physical interface between the work piece and its environment, which is based on a representation of non-ideal work pieces employing discrete geometry representation schemes. This paper presents a deviation analysis method for high-speed motorized spindle assembly using Skin Model Shapes, concerning all kinds of geometric deviations of the components. Deviations of the components are represented by the Skin Model Shapes, which is a point cloud-based discrete representative that is able to model the actual toleranced surfaces instead of the ideal or associated ones in an assembly. This paper solves the constrained objective function by means of the ideas of sequential quadratically constrained quadratic programming (SQCQP) method, which can solve problems with high degree of non-linearity and also has relatively small amount of calculation. The procedures outlined in the paper are quite general and can be used for tolerance analysis of any assembly process.
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- 2021
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177. Enhanced gas production efficiency of class 1,2,3 hydrate reservoirs using hydraulic fracturing technique
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Jianchun Xu, Huating Qin, Hangyu Li, Cheng Lu, Shuxia Li, and Didi Wu
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General Energy ,Mechanical Engineering ,Building and Construction ,Electrical and Electronic Engineering ,Pollution ,Industrial and Manufacturing Engineering ,Civil and Structural Engineering - Published
- 2023
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178. Dynamic spillover capacity of R&D and digital investments in China's manufacturing industry under long-term technological progress based on the industry chain perspective
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Wei Zhang, Ting Zhang, Hangyu Li, and Han Zhang
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Sociology and Political Science ,Human Factors and Ergonomics ,Business and International Management ,Education - Published
- 2022
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179. Design and Analysis of Low Signaling Overhead Multiple Access Protocol for Wireless Ad Hoc Networks
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Hangyu Li, Tao Jing, and Xu Li
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Computer science ,business.industry ,Wireless ad hoc network ,Channel access method ,Overhead (computing) ,business ,Computer network - Published
- 2021
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180. A Novel Machine Learning Assisted Upscaling Workflow for Simulating the Waterflooding Process
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Ling Fan, Xiaopu Wang, Shuyang Liu, Jianchun Xu, Yanji Wang, and Hangyu Li
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Workflow ,Computer science ,Process (engineering) ,business.industry ,Software engineering ,business - Abstract
Conventional flow-based two-phase upscaling for simulating the waterflooding process requires the calculations of upscaled two-phase parameters for each coarse interface or block. The whole procedure can be greatly time-consuming especially for large-scale reservoir models. To address this problem, flow-based two-phase upscaling techniques are combined with machine learning algorithms, in which the flow-based two-phase upscaling is needed only for a small fraction of coarse interfaces (or blocks), while the upscaled two-phase parameters for the rest of the coarse interfaces (or blocks) are directly provided by the machine learning algorithms instead of performing upscaling computation on each coarse interfaces (or blocks). The new two-phase upscaling workflow was tested for generic (left to right) flow problems using a 2D large-scale model. We observed similar accuracy for results using the machine learning assisted workflow compared with the results using full flow-based upscaling. And significant speedup (nearly 70) is achieved. The workflow developed in this work is one of the pioneering work in combining machine learning algorithm with the time-consuming flow-based two-phase upscaling method. It is a valuable addition to the existing multiscale techniques for subsurface flow simulation.
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- 2021
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181. Programmable light-driven swimming actuators via wavelength signal switching
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Dongshi Guan, Hangyu Li, Yue Long, Yongqi Sun, Kai Song, and Kai Hou
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Wavelength ,Multidisciplinary ,Computer science ,Acoustics ,Light driven ,Actuator ,Signal - Abstract
Light-driven swimming actuators with different motion modes could lead to many previously unachievable applications. However, controllable navigation often requires focusing light precisely on certain positions of the actuator, which is unfavorable for accurate dynamical operation or in microscale applications. Here, we present a type of programmable swimming actuators that can execute wavelength-dependent multidirectional motions via the Marangoni effect. Several multi–degree of freedom swimming motions have been realized: Forward-and-backward and zigzag actuators can execute one-dimensional (1D) and 2D linear motion, respectively; bidirectional gear rotation as angular motion can be regulated to obtain tunable speeds; and the turning actuator as a “freighter” is able to turn left, right, and go straight for precise maze navigation. A mechanical measurement system is established to quantitatively measure the driving force of the motion directly. The accessible wavelength-selective strategy presented here can inspire further explorations of simple and practical light-driven materials and systems.
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- 2021
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182. The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders
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Sheng Zhang, Xueqiang Peng, Shuo Yang, Xinyu Li, Mingyao Huang, Shibo Wei, Jiaxing Liu, Guangpeng He, Hongyu Zheng, Liang Yang, Hangyu Li, and Qing Fan
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Cancer Research ,Cellular and Molecular Neuroscience ,QH573-671 ,Metabolic Diseases ,Immunology ,Fatty Acids ,Autophagy ,Humans ,Cell Biology ,Lipid Droplets ,Cytology ,Lipid Metabolism ,Lysosomes - Abstract
Abstract Autophagy is a conserved method of quality control in which cytoplasmic contents are degraded via lysosomes. Lipophagy, a form of selective autophagy and a novel type of lipid metabolism, has recently received much attention. Lipophagy is defined as the autophagic degradation of intracellular lipid droplets (LDs). Although much remains unknown, lipophagy appears to play a significant role in many organisms, cell types, metabolic states, and diseases. It participates in the regulation of intracellular lipid storage, intracellular free lipid levels (e.g., fatty acids), and energy balance. However, it remains unclear how intracellular lipids regulate autophagy. Impaired lipophagy can cause cells to become sensitive to death stimuli and may be responsible for the onset of a variety of diseases, including nonalcoholic fatty liver disease and metabolic syndrome. Like autophagy, the role of lipophagy in cancer is poorly understood, although analysis of specific autophagy receptors has helped to expand the diversity of chemotherapeutic targets. These studies have stimulated increasing interest in the role of lipophagy in the pathogenesis and treatment of cancer and other human diseases.
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- 2021
183. miR-425 regulates lipophagy via SIRT1 to promote sorafenib resistance in liver cancer
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Hongyuan Jin, Liang Yang, Bowen Li, Gongping Sun, Hangyu Li, and Shibo Wei
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Cancer Research ,autophagy ,Oncogene ,business.industry ,Autophagy ,Cancer ,miR-425 ,Articles ,Cell cycle ,medicine.disease ,Metastasis ,liver cancer ,SIRT1 ,Oncology ,Tumor progression ,microRNA ,medicine ,Cancer research ,lipophagy ,business ,Liver cancer - Abstract
Liver cancer is one of the most malignant cancer, with poor outcomes and a high incidence rate, and current treatment approaches to prevent tumor progression and development remain unsatisfactory. Therefore, it is urgent to explore novel methods to inhibit tumor growth and metastasis. Autophagy is a highly conserved process associated with metastasis and drug resistance. Lipids are selectively recognized and degraded via autophagy; thus, autophagy is a crucial process to maintain tumor self-protection. MicroRNA (miR)-425 is a tumor-associated gene involved in liver cancer development that can induce cell proliferation and drug resistance. Using Cell Counting Kit-8 assays, western blot analysis and immunofluorescence assays, the present study revealed that inhibition of miR-425 promoted lipophagy by mediating the autophagy process, which in turn helps to promote sorafenib resistance. Using a bioinformatics website, it was revealed that autophagy promoted lipophagy by targeting silent information regulator 2 homolog 1 (SIRT1). The results of luciferase reporter assays supported this finding, and rescue experiments provided additional evidence. Overall, the current results suggested that inhibition of miR-425 expression increased SIRT1 expression to promote lipophagy, leading to the inhibition of liver cancer cell proliferation.
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- 2021
184. Pose estimation for monocular image object using convolution neural network
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Chuwei Li, Han Wu, Hangyu Li, and Zhilong Zhang
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Artificial neural network ,business.industry ,Computer science ,Rendezvous ,Computer vision ,Artificial intelligence ,business ,Object (computer science) ,Convolutional neural network ,Pose ,Feature learning ,Object detection ,Convolution - Abstract
Obtaining the accurate position and attitude of the object is the key to realize rendezvous and docking, on-orbit maintenance and other related tasks of space spacecraft. However, for non-cooperative objects, they lack prearranged cooperation sign, which would make it much more difficult to estimate their pose. Therefore, this paper attempts to use the powerful feature learning ability of neural network to establish the mapping relationship between the object in image and its current pose, then regresses the pose parameters of the object from a monocular image. Finally, we tested and verified the network on the public satellite dataset called Speed. The results showed that the translation error was 0.1237 and the rotation error was 0.1335.
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- 2021
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185. CISD2 Promotes Resistance to Sorafenib-Induced Ferroptosis by Regulating Autophagy in Hepatocellular Carcinoma
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Shuo Yang, Hangyu Li, Xueqiang Peng, Jingang Liu, Mingyao Huang, Shilei Tang, Hongyuan Jin, Liang Yang, Qing Fan, Bo Wu, Yingbo Ma, Shibo Wei, Bowen Li, and Xinyu Li
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Sorafenib ,Cancer Research ,Gene knockdown ,autophagy ,Chemistry ,Autophagy ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,sorafenib resistance ,Transfection ,hepatocellular carcinoma ,digestive system diseases ,ferroptosis ,Small hairpin RNA ,CISD2 ,Oncology ,Apoptosis ,medicine ,Cancer research ,Viability assay ,Beclin1 ,neoplasms ,RC254-282 ,PI3K/AKT/mTOR pathway ,medicine.drug ,Original Research - Abstract
PurposeSorafenib is a multi-kinase inhibitor that is used as a standard treatment for advanced hepatocellular carcinoma (HCC). However, the mechanism of sorafenib resistance in HCC is still unclear. It has been shown that CISD2 expression is related to the progression and poor prognosis of HCC. Here, we show a new role for CISD2 in sorafenib resistance in HCC.MethodsBioinformatic analysis was used to detect the expression of negative regulatory genes of ferroptosis in sorafenib-resistant samples. The concentration gradient method was used to establish sorafenib-resistant HCC cells. Western blot was used to detect the protein expression of CISD2, LC3, ERK, PI3K, AKT, mTOR, and Beclin1 in HCC samples. Quantitative real-time PCR (qPCR) was used to detect gene expression. CISD2 shRNA and Beclin1 shRNA were transfected to knock down the expression of the corresponding genes. Cell viability was detected by a CCK-8 assay. ROS were detected by DCFH-DA staining, and MDA and GSH were detected with a Lipid Peroxidation MDA Assay Kit and Micro Reduced Glutathione (GSH) Assay Kit, respectively. Flow cytometry was used to detect apoptosis and the levels of ROS and iron ions.ResultsCISD2 was highly expressed in HCC cells compared with normal cells and was associated with poor prognosis in patients. Knockdown of CISD2 promoted a decrease in the viability of drug-resistant HCC cells. CISD2 knockdown promoted sorafenib-induced ferroptosis in resistant HCC cells. The levels of ROS, MDA, and iron ions increased, but the change in GSH was not obvious. Knockdown of CISD2 promoted uncontrolled autophagy in resistant HCC cells. Inhibition of autophagy attenuated CISD2 knockdown-induced ferroptosis. The autophagy promoted by CISD2 knockdown was related to Beclin1. When CISD2 and Beclin1 were inhibited, the effect on ferroptosis was correspondingly weakened.ConclusionInhibition of CISD2 promoted sorafenib-induced ferroptosis in resistant cells, and this process promoted excessive iron ion accumulation through autophagy, leading to ferroptosis. The combination of CISD2 inhibition and sorafenib treatment is an effective therapeutic strategy for resistant HCC.
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- 2021
186. LncRNA NEAT1 promotes autophagy via regulating miR‐204/ATG3 and enhanced cell resistance to sorafenib in hepatocellular carcinoma
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Hangyu Li, Liang Yang, Xueqiang Peng, Yong Zhou, Shuo Yang, Yingbo Ma, Xinyu Li, and Jingang Liu
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0301 basic medicine ,Sorafenib ,Carcinoma, Hepatocellular ,Carcinogenesis ,Physiology ,Clinical Biochemistry ,Autophagy-Related Proteins ,Biology ,medicine.disease_cause ,Cell resistance ,03 medical and health sciences ,0302 clinical medicine ,Downregulation and upregulation ,Cell Line, Tumor ,microRNA ,Autophagy ,medicine ,Humans ,Survival rate ,Liver Neoplasms ,Hep G2 Cells ,Cell Biology ,medicine.disease ,digestive system diseases ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,030104 developmental biology ,Drug Resistance, Neoplasm ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Ubiquitin-Conjugating Enzymes ,Cancer research ,RNA, Long Noncoding ,medicine.drug - Abstract
Long noncoding RNAs (lncRNAs) has been acknowledged in tumorigenesis gradually because of the great importance in different cancers. LncRNA nuclear enriched abundant transcript 1 (NEAT1) is a novel lncRNA and has been reported to promote multiple cancer progression. However, the biological roles of NEAT1 in hepatocellular carcinoma (HCC) is not cleared nowadays. In the present research, the level of NEAT1 was found to be upregulated in HCC by The Cancer Genome Atlas. In addition, NEAT1 expression is negatively correlated with the survival rate in HCC. Further investigation revealed that NEAT1 upregulation inhibited sorafenib efficacy and promoted autophagy. We found that NEAT1 could be a sponge for microRNA-204 (miR-204) and inhibits its level to upregulate ATG3 expression. In addition to the above, we demonstrated that miR-204 mimics also attenuated tumor autophagy. And rescue assays demonstrated that NEAT1 promotes HCC autophagy through modulating miR-204/ATG3 pathway. Collectively, this study first demonstrated that a novel NEAT1/miR-204/ATG3 signaling regulates HCC progression.
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- 2019
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187. Hot deformation and dynamic recrystallization behavior of Cu-3Ti-3Ni-0.5Si alloy
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Jituo Liu, Yanfeng Liu, Hangyu Li, Xianhui Wang, Jia Liu, and Chan Wang
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Materials science ,Deformation (mechanics) ,Mechanical Engineering ,Metals and Alloys ,Nucleation ,02 engineering and technology ,Strain rate ,Flow stress ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Stress (mechanics) ,Hot working ,Mechanics of Materials ,Materials Chemistry ,Dynamic recrystallization ,Dislocation ,Composite material ,0210 nano-technology - Abstract
Hot deformation characteristics and dynamic recrystallization of Cu-3Ti-3Ni-0.5Si alloy were studied systematically in the range of 700–850 °C and at the strain rate of 0.01–10 s−1. The results show that the peak stress increases with decrease of temperature or increase of strain rate. The stress values of true strain are used for constructing constitutive equations and the constitutive equation model can well predict the flow stress of the Cu-3Ti-3Ni-0.5Si alloy. The processing map based on the dynamic materials model is composed of a power dissipation map and an instability map and the processing map show that an appropriate hot working process is in the range of 750–800 °C and at the strain rate of 0.1 s−1. After hot compressive deformation at 850 °C with different strain rates, the volume fraction of dynamic recrystallization decreases with increasing strain rate. The dislocation tangle and dislocation pile-up generate close to the precipitate. The recrystallized nuclei appeared on the surface of the coarse precipitates and a small number of recrystallized nuclei formed at the trigeminal boundary can effectively promote the growth of the dynamic recrystallized nuclei. The precipitation of Ni3Ti phase promotes the nucleation of dynamic recrystallization, and is beneficial for the formation of stability deformation domains. The precipitation of Ni2Si phase inhibits the occurrence of dynamic recrystallization, giving rise to the formation of instability deformation domains.
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- 2019
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188. Effect of Ni addition on the arc-erosion behavior of AgTiB2 contact material
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Yong Xi, Hangyu Li, Xiuhua Guo, Xianhui Wang, and Zhu Ting
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010302 applied physics ,Materials science ,Scanning electron microscope ,Enthalpy ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Surfaces, Coatings and Films ,Anode ,Cathodic protection ,Arc (geometry) ,Ionization ,0103 physical sciences ,Erosion ,Composite material ,Ionization energy ,0210 nano-technology ,Instrumentation - Abstract
To disclose the electrical characteristics of AgTiB2 contact materials with different Ni additions, the arc-erosion tests were performed 20,000 times at 24 V/16 A DC. The morphology and chemical composition of arc eroded contact surface were characterized by scanning electron microscopy and energy dispersive X-ray spectrometry, the mass change after arc-erosion tests was determined, the arc energy and arc duration at make-arc and break-arc were analyzed, and the arc erosion mechanism was discussed as well. The results show that arc erosion mode changes from anodic erosion to cathodic erosion with Ni addition. The Ag-4 wt.%TiB2 contact material with 2 wt%Ni addition has the optimum performance along with the least mass loss, while especially high arc energy and total mass loss generate at 4 wt% and 8 wt%Ni. Furthermore, the arc erosion mechanism was discussed based on the contact characterization, thermal property and ionization energy of materials. It is believed that excessive Ni addition is not beneficial for the improvement of arc erosion resistance since Ni has large potential to be ionized and the possibility to evaporate due to its little difference of enthalpy change compared with ionization energy.
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- 2019
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189. C2Net: A Network-Efficient Approach to Collision Counting LSH Similarity Join
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Sarana Nutanong, Hong Xu, Chenyun Yu, Hangyu Li, and Foryu Ha
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Distributed database ,Computer science ,Nearest neighbor search ,Hash function ,02 engineering and technology ,Minimum spanning tree ,Cartesian product ,Bottleneck ,Spectral clustering ,Computer Science Applications ,Locality-sensitive hashing ,symbols.namesake ,Computational Theory and Mathematics ,020204 information systems ,0202 electrical engineering, electronic engineering, information engineering ,symbols ,Algorithm ,Information Systems - Abstract
Similarity join of two datasets $P$ and $Q$ is a primitive operation that is useful in many application domains. The operation involves identifying pairs $(p,q)$ , in the Cartesian product of $P$ and $Q$ such that $(p,q)$ satisfies a stipulated similarity condition. In a high-dimensional space, an approximate similarity join based on locality-sensitive hashing (LSH) provides a good solution while reducing the processing cost with a predictable loss of accuracy. A distributed processing framework such as MapReduce allows the handling of large and high-dimensional datasets. However, network cost estimation frequently turns into a bottleneck in a distributed processing environment, thus resulting in a challenge of achieving faster and more efficient similarity join. This paper focuses on collision counting LSH-based similarity join in MapReduce and proposes a network-efficient solution called C2Net to improve the utilization of MapReduce combiners. The solution uses two graph partitioning schemes: (i) minimum spanning tree for organizing LSH buckets replication; and (ii) spectral clustering for runtime collision counting task scheduling. Experiments have shown that, in comparison to the state of the art, the proposed solution is able to achieve 20 percent data reduction and 50 percent reduction in shuffle time.
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- 2019
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190. Numerical simulation of THMC coupling temperature prediction for fractured horizontal wells in shale oil reservoir
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Rongli Xu, Tiankui Guo, Zhanqing Qu, Huanpeng Chen, Ming Chen, Jianchun Xu, and Hangyu Li
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Fuel Technology ,Geotechnical Engineering and Engineering Geology - Published
- 2022
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191. Quantitative study of CO2 huff-n-puff enhanced oil recovery in tight formation using online NMR technology
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Junrong Liu, Hangyu Li, Qizhi Tan, Shuyang Liu, Hailong Zhao, and Zhiqiang Wang
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Fuel Technology ,Geotechnical Engineering and Engineering Geology - Published
- 2022
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192. Corrigendum to 'Pore-scale flow simulation on the permeability in hydrate-bearing sediments' [Fuel 312 (2022) 122681]
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Jianchun Xu, Ziwei Bu, Hangyu Li, Shuxia Li, and Baojiang Sun
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Fuel Technology ,General Chemical Engineering ,Organic Chemistry ,Energy Engineering and Power Technology - Published
- 2022
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193. Rab GTPases: Central Coordinators of Membrane Trafficking in Cancer
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Shuo Yang, Bo Wu, Shilei Tang, Hangyu Li, Hongyuan Jin, Liang Yang, Xueqiang Peng, Mingyao Huang, Yuanxin Tang, Xinyu Li, Bowen Li, Qin Fan, Shibo Wei, and Jingang Liu
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QH301-705.5 ,membrane trafficking ,Autophagy ,Cell Biology ,GTPase ,Review ,Membrane transport ,Biology ,Exosome ,GDP ,Cell biology ,Cell and Developmental Biology ,Tumor progression ,Secretion ,Rab ,GEF ,Biology (General) ,Cytoskeleton ,Rab GTPase ,Developmental Biology ,cancer biology - Abstract
Tumor progression involves invasion, migration, metabolism, autophagy, exosome secretion, and drug resistance. Cargos transported by membrane vesicle trafficking underlie all of these processes. Rab GTPases, which, through coordinated and dynamic intracellular membrane trafficking alongside cytoskeletal pathways, determine the maintenance of homeostasis and a series of cellular functions. The mechanism of vesicle movement regulated by Rab GTPases plays essential roles in cancers. Therefore, targeting Rab GTPases to adjust membrane trafficking has the potential to become a novel way to adjust cancer treatment. In this review, we describe the characteristics of Rab GTPases; in particular, we discuss the role of their activation in the regulation of membrane transport and provide examples of Rab GTPases regulating membrane transport in tumor progression. Finally, we discuss the clinical implications and the potential as a cancer therapeutic target of Rab GTPases.
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- 2021
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194. Effect of electric load characteristics on the arc-erosion behavior of Ag-4 wt.%TiB2-4 wt.%Ni electrical contact material
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Yuan Fei, Xianhui Wang, Hang Zhang, Jituo Liu, and Hangyu Li
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010302 applied physics ,Materials science ,Electrical load ,Scanning electron microscope ,Energy-dispersive X-ray spectroscopy ,Spark plasma sintering ,02 engineering and technology ,General Chemistry ,Welding ,021001 nanoscience & nanotechnology ,Microstructure ,01 natural sciences ,Electrical contacts ,law.invention ,Transmission electron microscopy ,law ,0103 physical sciences ,General Materials Science ,Composite material ,0210 nano-technology - Abstract
To clarify the effect of electric load characteristics on the arc-erosion behavior of Ag base electrical contact material, the Ag-4 wt.%TiB2-4 wt.%Ni contact material was fabricated by spark plasma sintering, and the arc-erosion tests were performed at inductive load 18, 24 and 30 V and resistive load 30 V. The microstructure of the material was characterized by scanning electron microscopy and transmission electron microscopy, and the eroded morphology was examined by laser scanning confocal microscopy and scanning electron microscopy equipped with an energy dispersive spectroscopy (EDS). The arc-erosion mechanism was discussed based on the analysis of arc-duration, arc-energy, welding force and arc voltage/current waveforms. The results showed that there is less arc erosion under the resistive load as compared to the inductive load at the same voltage. The EDS analysis demonstrated that Ti and Ni are oxidized during arc erosion, which results in the decrease in the contact stability and the increase in make-arc-duration/energy and its standard deviation. Moreover, a larger mass loss occurs under the inductive load as compared to the resistive load, which can be attributed to the current/voltage shock triggered by the inductor during make operations.
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- 2021
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195. Zeolitic Imidazolate Framework ‐8‐Based Passive Daytime Radiative Cooling Paint for Energy‐Efficient Cooling
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Hangyu Lim, Jaein Park, Dongwoo Chae, Seongwoo Park, Sooyoung Kim, and Heon Lee
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metal–organic framework ,paint ,radiative cooling ,super‐hydrophobic surface ,ZIF‐8 ,Environmental technology. Sanitary engineering ,TD1-1066 ,Renewable energy sources ,TJ807-830 - Abstract
Increased energy consumption, driven by climate change and the rise of new industries, has spurred a demand for alternative cooling technologies to replace energy‐intensive systems and mitigate environmental pollution. Radiative cooling, leveraging the optical properties of materials to cool without emitting pollutants or consuming energy, is considered a suitable solution. Among the various form of radiative cooling devices, paint stands out as a practical application for radiative cooling. Hence, a passive daytime radiative cooling (PDRC) paint is developed using a polyurethane binder and zeolitic imidazolate framework (ZIF)‐8. ZIF‐8 is synthesized in an environmentally friendly manner using deionized water as the solvent, resulting in paint with a reflectance of 94.9%, emissivity of 94%, and cooling power of 113 W m−2. Temperature measurements reveal that the paint reduced ambient temperatures by an average of 5.7 °C, reaching up to 8.1 °C during the day. Additionally, with a self‐assembly monolayer coating, the PDRC surface exhibited super‐hydrophobicity and self‐cleaning capabilities. Therefore, the proposed ZIF‐8‐based PDRC paint offers sub‐room temperature cooling potential and is anticipated to reduce energy consumption for cooling, thereby alleviating environmental pollution in various applications, particularly in building exteriors.
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- 2024
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196. Association between vitamin D receptor gene polymorphisms and susceptibility to tuberculosis: a systematic review and meta-analysis
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Rongshan Tao, Shujuan Xiao, Lianping Wang, Chunjie Hu, Huiqin Suo, Ruiyu Long, Hangyu Liu, Wei Luo, Feng Hong, Jingming Zhao, and Qingjie Li
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tuberculosis ,gene polymorphisms ,VDR ,vitamin D receptor ,meta-analysis ,Genetics ,QH426-470 - Abstract
ObjectiveTuberculosis (TB) is the leading cause of mortality worldwide. Previous studies have reported that TB susceptibility can be caused by vitamin D deficiency, which is affected by polymorphisms in the vitamin D receptor (VDR) gene. However, these results have been inconsistent. Therefore, we performed a meta-analysis to investigate the association between VDR polymorphisms and TB susceptibility.MethodsWe systematically searched for relevant literature in PubMed, Embase, and Medline databases through December 31st, 2022. Inclusion and exclusion criteria were made to ensure that HIV-negative population is the targeted subjects. The pooled odds ratio (OR) and 95% confidence interval (CI) were then used to assess the strength of the association, and the quality of the included articles was evaluated using the Newcastle–Ottawa Scale. Potential sources of heterogeneity were evaluated based on subgroup and meta-regression analyses.ResultsIn our meta-analysis, we found that the FokI polymorphism in the VDR gene was associated with increased TB susceptibility in the allele and recessive genotype models (OR f vs. F = 1.235, 95%CI: 1.035–1.475; OR ff vs. Ff + FF = 1.317, 95%CI: 1.005–1.727. Further subgroup analysis based on ethnicity demonstrated the association with the risk of TB in all genotype models of the FokI polymorphism for Han population. Meta-regression analysis also indicated that ethnicity could be a potential source of heterogeneity in the FokI and BsmI polymorphisms in the VDR gene. However, publication year was another source of heterogeneity for the TaqI polymorphism.ConclusionIn summary, the FokI polymorphism in the VDR gene was found to increase the risk of TB in the HIV-negative population, both overall and in Asian populations. The findings presented in this paper could provide clues for preventing TB from the perspective of vitamin D supplementation, which is a controversial topic in the field of medicine and health.
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- 2024
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197. The Application of Machine Learning Algorithm in Relative Permeability Upscaling for Oil-Water System
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Ling Fan, Hangyu Li, Jianchun Xu, Yanji Wang, and Ji Tian
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Petroleum engineering ,Oil water ,010103 numerical & computational mathematics ,0101 mathematics ,Relative permeability ,01 natural sciences ,Geology - Abstract
Traditional two-phase relative permeability upscaling requires the fine-scale two-phase flow simulation over the target regions/blocks. It can be very computationally expensive especially for cases with multiple (hundreds of) geological realizations (as commonly used in subsurface uncertainty quantification or optimization). In this paper, we develop a machine learning assisted relative permeability upscaling procedure, in which the full numerical upscaling is performed for only a portion of the coarse blocks, while the upscaled functions for the rest of the coarse blocks are calculated by the machine learning algorithm. The upscaling procedure was tested for generic (left to right) flow problems using 2D models for scenarios involving multiple realizations. Numerical results have shown that the coarse-scale simulation results using the newly developed machine learning assisted upscaling procedure are of similar accuracy to the coarse results using full numerical upscaling. Because the fine-scale numerical simulation is only performed for a small fraction of the model, significant speedup is achieved.
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- 2021
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198. LINC00511 drives invasive behavior in hepatocellular carcinoma by regulating exosome secretion and invadopodia formation
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Hangyu Li, Shilei Tang, Yan Li, Mingyao Huang, Yingbo Ma, Shibo Wei, Jingang Liu, Shuo Yang, Xinyu Li, Bowen Li, Xueqiang Peng, Qing Fan, Bo Wu, Hongyuan Jin, and Liang Yang
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0301 basic medicine ,Cancer Research ,Carcinoma, Hepatocellular ,Carcinogenesis ,Hepatocellular carcinoma ,Invadopodia ,medicine.disease_cause ,Exosomes ,Exosome ,R-SNARE Proteins ,03 medical and health sciences ,medicine ,Humans ,Secretion ,Neoplasm Invasiveness ,Multivesicular body ,Qc-SNARE Proteins ,LncRNAs ,RC254-282 ,030102 biochemistry & molecular biology ,Chemistry ,Research ,Liver Neoplasms ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Qb-SNARE Proteins ,Microvesicles ,Long non-coding RNA ,Cell biology ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,Vesicle-associated membrane protein ,Oncology ,Tumor progression ,Podosomes ,Disease Progression ,RNA, Long Noncoding - Abstract
Background Tumor cells are known to release large numbers of exosomes containing active substances that participate in cancer progression. Abnormally expressed long noncoding RNAs (lncRNAs) have been confirmed to regulate multiple processes associated with tumor progression. However, the mechanism by which lncRNAs affect exosome secretion remains unclear. Methods The underlying mechanisms of long noncoding RNA LINC00511 (LINC00511) regulation of multivesicular body (MVB) trafficking, exosome secretion, invadopodia formation, and tumor invasion were determined through gene set enrichment analysis (GSEA), immunoblotting, nanoparticle tracking analysis, confocal colocalization analysis, electron microscopy, and invasion experiments. Results We revealed that the tumorigenesis process is associated with a significant increase in vesicle secretion in hepatocellular carcinoma (HCC). Additionally, LINC00511 was significantly more highly expressed in HCC tissues and is related to vesicle trafficking and MVB distribution. We also found that in addition to the formation of invadopodia in HCC progression, abnormal LINC00511 induces invadopodia formation in HCC cells by regulating the colocalization of vesicle associated membrane protein 7 (VAMP7) and synaptosome associated protein 23 (SNAP23) to induce the invadopodia formation, which are key secretion sites for MVBs and control exosome secretion. Finally, we revealed that LINC0051-induced invadopodia and exosome secretion were involved in tumor progression. Conclusions Our experiments revealed novel findings on the relationship between LINC00511 dysregulation in HCC and invadopodia production and exosome secretion. This is a novel mechanism by which LINC00511 regulates invadopodia biogenesis and exosome secretion to further promote cancer progression.
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- 2021
199. The holographic algorithm and design for propagation of flexural Lamb waves and particles manipulation using elastic metasurfaces
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Hangyu Li, Zewei Hou, and Yongmao Pei
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Mechanics of Materials ,Mechanical Engineering ,Chemical Engineering (miscellaneous) ,Bioengineering ,Engineering (miscellaneous) - Published
- 2022
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200. Techno-economic analysis of using carbon capture and storage (CCS) in decarbonizing China's coal-fired power plants
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Shuyang Liu, Hangyu Li, Kai Zhang, and Hon Chung Lau
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Renewable Energy, Sustainability and the Environment ,Strategy and Management ,Building and Construction ,Industrial and Manufacturing Engineering ,General Environmental Science - Published
- 2022
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