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151. ‘SMASH’ recommendations for standardised microscopic arthritis scoring of histological sections from inflammatory arthritis animal models

Author

Hayer, Silvia, primary, Vervoordeldonk, Margriet J, additional, Denis, Maria C, additional, Armaka, Marietta, additional, Hoffmann, Markus, additional, Bäcklund, Johan, additional, Nandakumar, Kutty Selva, additional, Niederreiter, Birgit, additional, Geka, Christina, additional, Fischer, Anita, additional, Woodworth, Nina, additional, Blüml, Stephan, additional, Kollias, George, additional, Holmdahl, Rikard, additional, Apparailly, Florence, additional, and Koenders, Marije I, additional

Published
2021
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153. 高强度炎症反应诱导关节软骨特异性瓜氨酸化抗原表达

Author

Guicheng, Qin, Xiaoyin, Lin, Peibin, Liang, Yanpeng, Li, Chun, Zhou, Selva Nandakumar, Kutty, and Holmdahl, Rikard

Subjects
Cartilage, Articular, Inflammation, Rats, Sprague-Dawley, musculoskeletal diseases, Mice, 基础研究, Animals, Citrulline, Humans, Arthritis, Experimental, Autoantibodies, Rats
Abstract

OBJECTIVE: To investigate the expression of citrullinated epitopes in articular cartilage protein and whether its expression is sufficient to induce anti-citrullinated protein antibody (ACPA) response in mice. METHODS: The experimental group was treated with different concentrations of lipopolysaccharide (LPS), heat-inactivated bacteria (Escherichia coli and Staphylococcus aureus) or specific monoclonal antibody against type Ⅱ collagen to induce citrullination of articular cartilage protein, with PBS as the control. Immunohistochemistry with the monoclonal antibody ACC4 (IgG1) that specifically binds to the citrullinated epitope of cartilage protein was performed for detecting the expression of citrullinated protein, with ACC1 (IgG2a) as a positive control antibody and L243 (IgG2a) and Hy2.15 (IgG1) as the negative isotype control. In the in vivo experiment, SD rats were subjected to injection of different doses of LPS in the right knee (with PBS as the controls in the left knee), and 3 days later frozen sections were prepared for immunohistochemical detection of the expression of citrullinated protein. Models of collagen-induced arthritis (CIA) established in different mouse strains were observed for incidence and severity of CIA. Serum samples collected from these models and the sera from rheumatoid arthritis patients were examined for anti-citrullinated protein antibody, and immunohistochemistry was performed to detect the expression of citrullinated protein in the cartilage of the mouse. RESULTS: The citrullinated CII epitope-specific antibody ACC4 did not bind to articular cartilage tissues with different treatments as compared with the positive control antibody ACC1. The ACC4 antibody and the antibodies from patients with rheumatoid arthritis with high titers of anti-citrullinated protein antibody were capable of binding to the synovial tissue around the articular cartilage of the CIA. Luminex analysis showed that the anti-citrullinated protein antibody was lowly expressed in mouse serum, but the anti-type Ⅱ collagen triple helix structure peptide antibody exhibited strong reactivity. CONCLUSION: Mild acute inflammatory response is not enough to cause citrullination of articular cartilage protein, and the expression of specific epitope requires a high-intensity inflammatory response. Inflammatory articular cartilage protein can express citrullinated epitopes in type Ⅱ collagen-induced arthritis in mice, but the expression of citrullinated epitopes is not sufficient to induce an immune response to anti-citrullinated antibodies. Stronger stimulation signals are required to induce an immune response for producing anti-citrullinated protein antibodies.

Published
2020

154. Additional file 3 of Presence of autoantibodies in 'seronegative' rheumatoid arthritis associates with classical risk factors and high disease activity

Author

Reed, Evan, Hedström, Anna Karin, Hansson, Monika, Mathsson-Alm, Linda, Boel Brynedal, Saedis Saevarsdottir, Cornillet, Martin, Per-Johan Jakobsson, Holmdahl, Rikard, Skriner, Karl, Serre, Guy, Alfredsson, Lars, Rönnelid, Johan, and Lundberg, Karin

Subjects
musculoskeletal diseases, immune system diseases, mental disorders, skin and connective tissue diseases
Abstract

Additional file 3: Supplementary Table 3. Baseline characteristics in CCP2-positive and -negative RA. The table show baseline characteristics for the EIRA patients included in the study, based on anti-CCP2 IgG status; p-values indicate differences between subsets with respect to: age, female-to-male ratio, number of smokers, HLA-DRB1 SE-positivity, PTPN22-positivity, DAS28 and CRP.

Published
2020
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156. Additional file 7 of Presence of autoantibodies in 'seronegative' rheumatoid arthritis associates with classical risk factors and high disease activity

Author

Reed, Evan, Hedström, Anna Karin, Hansson, Monika, Mathsson-Alm, Linda, Boel Brynedal, Saedis Saevarsdottir, Cornillet, Martin, Per-Johan Jakobsson, Holmdahl, Rikard, Skriner, Karl, Serre, Guy, Alfredsson, Lars, Rönnelid, Johan, and Lundberg, Karin

Subjects
musculoskeletal diseases, immune system diseases, mental disorders, skin and connective tissue diseases
Abstract

Additional file 7: Supplementary Table 6. Associations between different ACPA fine-specificities and HLA-DRB1 SE, in anti-CCP2-positive and anti-CCP2-negative RA. Odds ratios with 95% confidence intervals are shown for associations between HLA-DRB1 SE and presence/absence of 19 different ACPA fine-specificities, in anti-CCP2-positive and -negative RA: p-values indicate differences in ORs between ACPA fine-specificity-positive and -negative subsets in the anti-CCP2-positive subset.

Published
2020
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157. Additional file 1 of Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis

Author

Yanpeng Li, Dongmei Tong, Peibin Liang, Lönnblom, Erik, Viljanen, Johan, Bingze Xu, Kutty Selva Nandakumar, and Holmdahl, Rikard

Abstract

Additional file 1 : Table S1. Showing information about peptides sequences. The cyclic peptide \P6-R247 (239CHADSVLERDGSRSSVC255) shares the same core sequence with P6-R-R but contains additional Cys residues at both N and C terminus to facilitate the formation of an intra-chain disulfide bond and thus a cyclic form of the peptide in neutral buffer solution. c=citrulline.

Published
2020
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158. Additional file 6 of Presence of autoantibodies in 'seronegative' rheumatoid arthritis associates with classical risk factors and high disease activity

Author

Reed, Evan, Hedström, Anna Karin, Hansson, Monika, Mathsson-Alm, Linda, Boel Brynedal, Saedis Saevarsdottir, Cornillet, Martin, Per-Johan Jakobsson, Holmdahl, Rikard, Skriner, Karl, Serre, Guy, Alfredsson, Lars, Rönnelid, Johan, and Lundberg, Karin

Subjects
musculoskeletal diseases, immune system diseases, skin and connective tissue diseases
Abstract

Additional file 6: Supplementary Table 5. Associations between different autoantibodies and PTPN22 polymorphism, in anti-CCP2-negative RA. Odds ratios with 95% confidence intervals are shown for associations between PTPN22 polymorphism and presence/absence of ACPA, RF, other autoantibodies, or "any autoantibody" in anti-CCP2-negative RA.

Published
2020
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159. Additional file 4 of Presence of autoantibodies in 'seronegative' rheumatoid arthritis associates with classical risk factors and high disease activity

Author

Reed, Evan, Hedström, Anna Karin, Hansson, Monika, Mathsson-Alm, Linda, Boel Brynedal, Saedis Saevarsdottir, Cornillet, Martin, Per-Johan Jakobsson, Holmdahl, Rikard, Skriner, Karl, Serre, Guy, Alfredsson, Lars, Rönnelid, Johan, and Lundberg, Karin

Abstract

Additional file 4: Supplementary Figure 1. ACPA fine-specificity levels in anti-CCP2-negative RA and controls. ACPA levels for 19 individual ACPA fine-specificities are shown in separate graphs with AU values on the Y-axes. Only ACPA levels above cutoff for positivity are shown.

Published
2020
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160. Additional file 8 of Presence of autoantibodies in 'seronegative' rheumatoid arthritis associates with classical risk factors and high disease activity

Author

Reed, Evan, Hedström, Anna Karin, Hansson, Monika, Mathsson-Alm, Linda, Boel Brynedal, Saedis Saevarsdottir, Cornillet, Martin, Per-Johan Jakobsson, Holmdahl, Rikard, Skriner, Karl, Serre, Guy, Alfredsson, Lars, Rönnelid, Johan, and Lundberg, Karin

Subjects
musculoskeletal diseases, mental disorders, skin and connective tissue diseases
Abstract

Additional file 8: Supplementary Table 7. Associations between RF isotypes and smoking, in anti-CCP2-positive and anti-CCP2-negative RA. Odds ratios with 95% confidence intervals are shown for associations between smoking and presence/absence of IgM, IgG or IgA RF, in anti-CCP2-positive and -negative RA; p-values indicate differences in ORs between RF isotype-positive and -negative subsets.

Published
2020
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161. Additional file 3 of Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis

Author

Yanpeng Li, Dongmei Tong, Peibin Liang, Lönnblom, Erik, Viljanen, Johan, Bingze Xu, Kutty Selva Nandakumar, and Holmdahl, Rikard

Abstract

Additional file 3 : Table S3. Showing disease incidence and maximum arthritis score with isotype control antibodies. Isotype controls: G11 + L243 + Hy2.15; Mice: 12-weeks-old males; 5-6 mice/group. B-LPS: before lipopolysaccharide injection; A-LPS: after lipopolysaccharide injection.

Published
2020
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162. Additional file 2 of Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis

Author

Yanpeng Li, Dongmei Tong, Peibin Liang, Lönnblom, Erik, Viljanen, Johan, Bingze Xu, Kutty Selva Nandakumar, and Holmdahl, Rikard

Subjects
musculoskeletal diseases
Abstract

Additional file 2 : Table S2. Showing disease incidence and maximum arthritis score in BQ.Ncf1* mice. Comparisons were done between 2mg/4mg Cab3 and 2mg/4mg anti-CII in regard of max arthritis score. Significant difference was observed between 4mg Cab3 and 4mg anti-CII after LPS injection.

Published
2020
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163. Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species

Author

Gelderman, Kyra A., Hultqvist, Malin, Pizzolla, Angela, Zhao, Ming, Nandakumar, Kutty Selva, Mattsson, Ragnar, and Holmdahl, Rikard

Subjects
Arthritis -- Risk factors, Arthritis -- Genetic aspects, Arthritis -- Research, Macrophages -- Health aspects, Macrophages -- Research, T cells -- Health aspects, T cells -- Research
Abstract

Reduced capacity to produce ROS increases the severity of T cell-dependent arthritis in both mice and rats with polymorphisms in neutrophil cytosolic factor 1 (Ncf1) (p47phox). Since T cells cannot [...]

Published
2007

165. Contributors

Author

Abramson, Steven B., primary, An, Kai-Nan, additional, Andrade, Felipe, additional, Atkinson, John P., additional, Baeten, Dominique, additional, Baughman, Robert P., additional, Beaton, Dorcas E., additional, Bennett, Robert, additional, Benseler, Susanne M., additional, Bertsias, George, additional, Bhardwaj, Nina, additional, Bijlsma, Johannes W.J., additional, Bockenstedt, Linda K., additional, Boers, Maarten, additional, Boin, Francesco, additional, Boumpas, Dimitrios T., additional, Bresnihan, Barry, additional, Brettler, Doreen B., additional, Buckley, Christopher D., additional, Budd, Ralph C., additional, Burns, Christopher M., additional, Cannella, Amy C., additional, Chakravarty, Eliza F., additional, Chang, Christopher, additional, Cheng, Joseph S., additional, Chiodo, Christopher P., additional, Cleland, Leslie G., additional, Clowse, Megan E., additional, Cook, Paul P., additional, Craft, Joseph E., additional, Crofford, Leslie J., additional, Cronstein, Bruce N., additional, Crow, Mary K., additional, Cunnane, Gaye, additional, Cush, John J., additional, Cutolo, Maurizio, additional, Dall'Era, Maria, additional, Dao, Kathryn H., additional, Darrah, Erika, additional, Davis, John M., additional, DeGroot, Jeroen, additional, Devin, Clint, additional, Diamond, Betty, additional, Díaz-González, Federico, additional, Di Cesare, Paul E., additional, Dixit, Rajiv, additional, Drenth, Joost P.H., additional, Dustin, Michael L., additional, El-Gabalawy, Hani S., additional, Elkon, Keith B., additional, Erkan, Doruk, additional, Fanouriakis, Antonios, additional, Field, Max, additional, Filer, Andrew, additional, Firestein, Gary S., additional, Fitzgerald, Oliver, additional, Flaherty, John P., additional, Flanagan, Adrienne M., additional, Fortner, Karen A., additional, Gabriel, Sherine E., additional, Gaston, J.S. Hill, additional, Gay, Steffen, additional, Gershwin, M. Eric, additional, Gibofsky, Allan, additional, Ginsberg, Mark H., additional, Goldring, Mary B., additional, Goldring, Steven R., additional, Golightly, Yvonne M., additional, Goodman, Stuart, additional, Gordon, Siamon, additional, Grassi, Walter, additional, Greenspan, Adam, additional, Gregersen, Peter K., additional, Grimaldi, Christine, additional, Hajj-Ali, Rula A., additional, Harper, Lorraine, additional, Harris, Edward D., additional, Haudenschild, Dominik R., additional, Hellmann, David B., additional, Holmdahl, Rikard, additional, Hsu, Joyce J., additional, Huddleston, James I., additional, Huizinga, Thomas W.J., additional, Hunder, Gene G., additional, Hung, Emily W., additional, Inman, Robert D., additional, Iversen, Maura Daly, additional, Jacobs, Johannes W.G., additional, Jordan, Joanne M., additional, Jorizzo, Joseph L., additional, Kaufman, Kenton R., additional, Kaufman, William S., additional, Kavanaugh, Arthur, additional, Keenan, Robert T., additional, Khan, Shaukat, additional, Koch, Alisa E., additional, Kono, Dwight H., additional, Krakow, Deborah, additional, Lambert, Robert G.W., additional, Landewé, Robert B.M., additional, Lane, Nancy E., additional, Langford, Carol A., additional, Laskin, Daniel M., additional, Laxer, Ronald M., additional, Lee, David M., additional, Lee, Lela A., additional, Lee, Tzielan Chang, additional, Lockshin, Michael D., additional, Lories, Rik, additional, Lozada, Carlos J., additional, Lundberg, Ingrid E., additional, Luqmani, Raashid, additional, Luyten, Frank P., additional, Mader, Reuven, additional, Maksymowych, Walter P., additional, Mandell, Brian, additional, Martin, Scott David, additional, Matteson, Eric L., additional, McGirt, Matthew J., additional, McInnes, Iain B., additional, McNamara, Elizabeth Kaufman, additional, Mikuls, Ted R., additional, Miller, Mark S., additional, Moder, Kevin G., additional, Nagaraju, Kanneboyina, additional, Naides, Stanley J., additional, Nelson, Amanda E., additional, Nigrovic, Peter A., additional, Nistala, Kiran, additional, Nowatzky, Johannes, additional, O'Dell, James R., additional, Okada, Yasunori, additional, Orduño, Nataly Manjarrez, additional, Ospelt, Caroline, additional, Østergaard, Mikkel, additional, Palmer, Bradley M., additional, Panush, Richard S., additional, Peng, Stanford L., additional, Pillinger, Michael H., additional, Polston, Gregory R., additional, Porcelli, Steven A., additional, Price, Mark D., additional, Rasker, Johannes J., additional, Reveille, John D., additional, Roberts, W. Neal, additional, Ronneberger, Monika, additional, Rosen, Antony, additional, Rosenbaum, James T., additional, Rosenberg, Andrew E., additional, Ruderman, Eric M., additional, Ruutu, Merja, additional, Salmon, Jane E., additional, Samuels, Jonathan, additional, Sandborg, Christy I., additional, Savage, Caroline O.S., additional, Saxena, Amit, additional, Scher, Jose U., additional, Schett, Georg, additional, Seldin, David C., additional, Simon, Anna, additional, Siraj, Dawd S., additional, Skinner, Martha, additional, St. Clair, E. William, additional, Stamp, Lisa K., additional, Stone, John H., additional, Straub, Rainer H., additional, Sweeney, Susan E., additional, Sweiss, Nadera J., additional, Swigart, Carrie R., additional, Symmons, Deborah, additional, Szekanecz, Zoltan, additional, Tak, Paul-Peter, additional, Taylor, Peter C., additional, Terkeltaub, Robert, additional, Theofilopoulos, Argyrios N., additional, Thomas, Ranjeny, additional, Thornhill, Thomas S., additional, Torralba, Karina D., additional, Toth, Michael J., additional, Tugwell, Peter, additional, Tutuncu, Zuhre, additional, Upchurch, Katherine S., additional, van der Heijde, Désirée M.F.M., additional, van der Helm-van Mil, Annette H.M., additional, van der Linden, Sjef M., additional, van der Meer, Jos W.M., additional, van Laar, Jacob M., additional, Varga, John, additional, Wallace, Mark S., additional, Warshaw, David M., additional, Wedderburn, Lucy R., additional, Werth, Victoria P., additional, Wigley, Fredrick M., additional, Wise, Christopher M., additional, Wofsy, David, additional, Wolfe, Frederick, additional, Wollheim, Frank A., additional, Wortmann, Robert L., additional, Yelin, Edward, additional, Yu, David, additional, Zabriskie, John B., additional, Zurier, Robert B., additional, and Zuurmond, Anne-Marie, additional

Published
2013
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166. A new arthritis therapy with oxidative burst inducers

Author

Hultqvist, Malin, Olofsson, Peter, Gelderman, Kyra A., Holmberg, Jens, and Holmdahl, Rikard

Subjects
Arthritis -- Care and treatment, Arthritis -- Research, Autoimmune diseases -- Care and treatment, Autoimmune diseases -- Research
Abstract

ABSTRACT Background Despite recent successes with biological agents as therapy for autoimmune inflammatory diseases such as rheumatoid arthritis (RA), many patients fail to respond adequately to these treatments, making a [...]

Published
2006

167. Identification of genetic regions of importance for reproductive performance in female mice

Author

Liljander, Maria, Sallstrom, Mary-Ann, Andersson, Sara, Wernhoff, Patrik, Andersson, Asa, Holmdahl, Rikard, and Mattsson, Ragnar

Subjects
Quantitative trait loci -- Genetic aspects, Mice -- Genetic aspects, Mice -- Behavior, Biological sciences
Abstract

Both environmental and genetic factors can dramatically affect reproductive performance in mice. In this study we have focused on the identification of genetic regions, quantitative trait loci (QTL), which affect the breeding capacity of female mice. We have identified polymorphic microsatellite markers for the mouse strains used and perfbrmed a genomewide scan on 237 females from a gene-segregating backcross between a high breeder and a relatively poor breeder. The high-breeder mouse strain we used is the inbred NFR/N mouse (MHC haplotype H-2q), which has extraordinary good breeding properties. The moderate breeder chosen for [F.sub.1] and N2 progeny was B10.Q, which is a genetically well-characterized MHC-congenic mouse of the H-2q haplotype. Each of the 237 females of the N2 generation was allowed to mate twice with MHC-congenic B10.RIII (H-2r) males and twice with B10.Q, males. A predeterinined number of phenotypes related to reproductive performance were recorded, and these included litter size, neonatal growth, and pregnancy rate. Loci controlling litter size were detected on chromosomes 1 (Fecq3) and 9 (Fecq4). The neonatal growth phenotyqoe was affected by Fecq3 and a locus on chromosome 9 (Neogq1). On chromosome 11 two loci affecting the pregnancy rate (Pregql and Pregq2) were identified. Furthermore, on chromosomes 13 and 17 we found loci (Pregq3 and Pregq4) inflnencing the outcome of allogeneic pregnancy (allogeneic by means of MHC disparity between mother and fetuses). A locus on chromosome 1 affecting maternal body weight was also identified and has been denoted Bwq7. It is well known that reproductive performance is polygenically controlled, and the identification of the major loci in this complex process opens the possibility of investigating the natural genetic control of reproduction.

Published
2006

169. Correction to Synthesis of an Array of Triple-Helical Peptides from Type II Collagen for Multiplex Analysis of Autoantibodies in Rheumatoid Arthritis

Author

Viljanen, Johan, primary, Lönnblom, Erik, additional, Ge, Changrong, additional, Yang, Jie, additional, Cheng, Lei, additional, Aldi, Silvia, additional, Cai, Weiwei, additional, Kastbom, Alf, additional, Sjöwall, Christopher, additional, Fields, Gregg B., additional, Gjertsson, Inger, additional, Holmdahl, Rikard, additional, and Kihlberg, Jan, additional

Published
2020
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198. Animal models for arthritis: innovative tools for prevention and treatment

Author

Kollias, George, Papadaki, Piyi, Apparailly, Florence, Vervoordeldonk, Margriet J, Holmdahl, Rikard, Baumans, Vera, Desaintes, Christian, Di Santo, James, Distler, Jörg, Garside, Paul, Hegen, Martin, Huizinga, Tom W J, Jüngel, Astrid, Klareskog, Lars, McInnes, Iain, Ragoussis, Ioannis, Schett, Georg, Hart, Bert ‘t, Tak, Paul P, Toes, Rene, van den Berg, Wim, Wurst, Wolfgang, and Gay, Steffen

Published
2011
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199. Vitamin D3 receptor polymorphisms regulate T cells and T cell-dependent inflammatory diseases

Author

Fernandez Lahore, Gonzalo, primary, Raposo, Bruno, additional, Lagerquist, Marie, additional, Ohlsson, Claes, additional, Sabatier, Pierre, additional, Xu, Bingze, additional, Aoun, Mike, additional, James, Jaime, additional, Cai, Xiaojie, additional, Zubarev, Roman A., additional, Nandakumar, Kutty Selva, additional, and Holmdahl, Rikard, additional

Published
2020
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200. Synthesis of an Array of Triple-Helical Peptides from Type II Collagen for Multiplex Analysis of Autoantibodies in Rheumatoid Arthritis

Author

Viljanen, Johan, primary, Lönnblom, Erik, additional, Ge, Changrong, additional, Yang, Jie, additional, Cheng, Lei, additional, Aldi, Silvia, additional, Cai, Weiwei, additional, Kastbom, Alf, additional, Sjöwall, Christopher, additional, Gjertsson, Inger, additional, Holmdahl, Rikard, additional, and Kihlberg, Jan, additional

Published
2020
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