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Balance, reaction time, and strength are key factors affecting judo performance. Although ample research has been done examining potential strength changes caused by weight loss prior to competition, changes in balance and reaction time have been overlooked. Purpose: To examine the effects of rapid and progressive weight loss (RWL and PWL) on balance, reaction time, and strength in a group of elite judo athletes. Methods: A total of 38 female and male judo athletes (age = 20.6 [2.6] y) completed balance, reaction-time, and strength assessments 1 wk prior to an official weigh-in (pretest) and immediately after the weigh-in (posttest). The athletes were divided into 3 groups, 1 control group who maintained regular training and eating habits, 1 experimental group who engaged in PWL (3% reductions in body mass). Results: The RWL group showed significant decreases (P 2 with eyes closed; mean mediolateral velocity: 2.07 [0.2] vs 2.52 [0.45] mm·s−1 with eyes closed; and mean anteroposterior velocity: 2.25 [0.20] vs 2.51 [0.32] mm·s−1 with eyes open and 2.44 [0.26] vs 3.06 [0.56] mm·s−1 with eyes closed) and reaction time (0.38 [0.04] vs 0.42 [0.06] s) with no changes in strength from pretesting to posttesting. The athletes in the PWL and control groups maintained performance in all variables. Conclusion: These findings demonstrate negative effects on perceptual motor-skill performance in judo athletes engaging in RWL strategies prior to competition.

With the recent inclusion of surfing in the 2020 Olympic Games in Japan, there will be a number of surfing athletes vying for one of the twenty total available spots for their respective gender. The purpose was to evaluate relative age effects (RAEs) in surfing with consideration for specific developmental constraints. Elite competitive male surfers (n = 1590) were examined by birth month and subcategorized by competitive level, age groups, and geographical regions. The observed quarterly distribution was not significantly different (using χ2; p>0.05) from expected for the overall group or any of the subcategories. However, an odds ratio of 1.85 (90% confidence interval: 1.08–3.14) was calculated for being born in the first semester of the year compared to being born in the second semester between top 34 athletes and the rest of the field. Despite consideration for individual, environmental, and task constraints in this study, the sport of surfing does not appear to have any observable RAEs at the professional level. Thus, surfing appears to be one of the few sporting activities included in the Olympic Programme with limited RAEs.

Resistance training may differentially affect morphological adaptations along the length of uni-articular and bi-articular muscles. The purpose of this study was to compare changes in muscle morphology along the length of the rectus femoris (RF) and vastus lateralis (VL) in response to resistance training. Following a 2-wk preparatory phase, 15 resistance-trained men (24.0 ± 3.0 y, 90.0 ± 13.8 kg, 174.9 ± 20.7 cm) completed pre-training (PRE) assessments of muscle thickness (MT), pennation angle (PA), cross-sectional area (CSA), and echo-intensity in the RF and VL at 30, 50, and 70% of each muscle’s length; fascicle length (FL) was estimated from respective measurements of MT and PA within each muscle and region. Participants then began a high intensity, low volume (4 × 3 − 5 repetitions, 3min rest) lower-body resistance training program, and repeated all PRE-assessments after 8 weeks (2 d · wk−1) of training (POST). Although three-way (muscle [RF, VL] × region [30, 50, 70%] × time [PRE, POST]) repeated measures analysis of variance did not reveal significant interactions for any assessment of morphology, significant simple (muscle × time) effects were observed for CSA (p = 0.002) and FL (p = 0.016). Specifically, average CSA changes favored the VL (2.96 ± 0.69 cm2, pp < 0.001) over the RF (0.59 ± 0.20 cm2, p = 0.011), while significant decreases in average FL were noted for the RF (–1.03 ± 0.30 cm, p = 0.004) but not the VL (–0.05 ± 0.36 cm, p = 0.901). No other significant differences were observed. The findings of this study demonstrate the occurrence of non-homogenous adaptations in RF and VL muscle size and architecture following 8 weeks of high-intensity resistance training in resistance-trained men. However, training does not appear to influence region-specific adaptations in either muscle.

β-alanine supplementation increases muscle carnosine content and improves anaerobic exercise performance by enhancing intracellular buffering capacity. β-alanine ingestion in its traditional rapid-release formulation (RR) is associated with the symptoms of paresthesia. A sustained-release formulation (SR) of β-alanine has been shown to circumvent paresthesia and extend the period of supply to muscle for carnosine synthesis. The purpose of this investigation was to compare 28 days of SR and RR formulations of β-alanine (6 g day-1) on changes in carnosine content of the vastus lateralis and muscle fatigue. Thirty-nine recreationally active men and women were assigned to one of the three groups: SR, RR, or placebo (PLA). Participants supplementing with SR and RR formulations increased muscle carnosine content by 50.1% (3.87 mmol kg-1ww) and 37.9% (2.62 mmol kg-1ww), respectively. The change in muscle carnosine content in participants consuming SR was significantly different (p = 0.010) from those consuming PLA, but no significant difference was noted between RR and PLA (p = 0.077). Although participants ingesting SR experienced a 16.4% greater increase in muscle carnosine than RR, fatigue during maximal voluntary isometric contractions was significantly attenuated in both SR and RR compared to PLA (p = 0.002 and 0.024, respectively). Symptoms of paresthesia were significantly more frequent in RR compared to SR, the latter of which did not differ from PLA. Results of this study demonstrated that only participants consuming the SR formulation experienced a significant increase in muscle carnosine. Differences in the muscle carnosine response between these formulations may have practical significance for athletic populations in which small changes may have important implications on performance.

Resistance training may differentially affect morphological adaptations along the length of uni-articular and bi-articular muscles. The purpose of this study was to compare changes in muscle morphology along the length of the rectus femoris (RF) and vastus lateralis (VL) in response to resistance training. Following a 2-wk preparatory phase, 15 resistance-trained men (24.0 ± 3.0 y, 90.0 ± 13.8 kg, 174.9 ± 20.7 cm) completed pre-training (PRE) assessments of muscle thickness (MT), pennation angle (PA), cross-sectional area (CSA), and echo-intensity in the RF and VL at 30, 50, and 70% of each muscle's length; fascicle length (FL) was estimated from respective measurements of MT and PA within each muscle and region. Participants then began a high intensity, low volume (4 x 3-5 repetitions, 3min rest) lower-body resistance training program, and repeated all PRE-assessments after 8 weeks (2 d ∙ wk-1) of training (POST). Although three-way (muscle [RF, VL] x region [30, 50, 70%] x time [PRE, POST]) repeated measures analysis of variance did not reveal significant interactions for any assessment of morphology, significant simple (muscle x time) effects were observed for CSA (p = 0.002) and FL (p = 0.016). Specifically, average CSA changes favored the VL (2.96 ± 0.69 cm2, p < 0.001) over the RF (0.59 ± 0.20 cm2, p = 0.011), while significant decreases in average FL were noted for the RF (-1.03 ± 0.30 cm, p = 0.004) but not the VL (-0.05 ± 0.36 cm, p = 0.901). No other significant differences were observed. The findings of this study demonstrate the occurrence of non-homogenous adaptations in RF and VL muscle size and architecture following 8 weeks of high-intensity resistance training in resistance-trained men. However, training does not appear to influence region-specific adaptations in either muscle.

For solving constrained multicriteria problems, we introduce the multiobjective barrier method (MBM), which extends the scalar-valued internal penalty method. This multiobjective version of the classical method also requires a penalty barrier for the feasible set and a sequence of nonnegative penalty parameters. Differently from the single-valued procedure, MBM is implemented by means of an auxiliary "monotonic" real-valued mapping, which may be chosen in a quite large set of functions. Here, we consider problems with continuous objective functions, where the feasible sets are defined by finitely many continuous inequalities. Under mild assumptions, and depending on the monotonicity type of the auxiliary function, we establish convergence to Pareto or weak Pareto optima. Finally, we also propose an implementable version of MBM for seeking local optima and analyze its convergence to Pareto or weak Pareto solutions.

Carballeira, E, Morales, J, Fukuda, DH, Granada, ML, Carratalá-Deval, V, López Díaz de Durana, A, and Stout, JR. Intermittent cooling during Judo training in a warm/humid environment reduces autonomic and hormonal impact. J Strength Cond Res 33(8): 2241-2250, 2019-The purpose of this study was to identify the effects of superficial cooling on physiological responses while training in a warm, humid environment during an international Judo training camp. Sixteen judokas (8 women and 8 men) participated in the experiment. Four high-level women and 4 men were randomly assigned to wear a cooling vest (vest group [VG]) during the recovery periods within a training session (i.e., 8 bouts of 5-minute fighting with 5-minute rest) and up to 10 minutes after the session, whereas the remaining athletes in the control group (CG) trained without the use of any cooling aids. No differences between groups were reported in well-being before the session or in perceived fatigue after the session. The temperature was increased after the training session (p = 0.02) without significant differences between groups; however, CG demonstrated a moderate effect size (ES = 0.95, 90% confidence interval [CI] = 0.09-1.82; probability of superiority [PS] = 74.9%) in contrast to the small effect for VG (ES = 0.28, 90% CI = -0.55 to 1.11; PS = 57.9%). There were time × group interactions for heart rate variability (lnRMSSD) (p = 0.006; VG vs. CG, PS = 79.0%) and the dehydroepiandrosterone-cortisol ratio (DHEA/C ratio) (p = 0.04; VG vs. CG, PS = 99.9%). Vest group preserved the cardiac autonomic control (p= 0.05; ES = -0.06, 90% CI = -0.88 to 0.76; PS = 51.7%) compared with the large decrement of CG (p0.05; ES = -1.18, 90% CI = -2.07 to -0.29; PS = 74.9%). Furthermore, VG showed an increase of DHEA/C (p = 0.002) from presession to postsession based on a moderate decrease of cortisol (p= 0.05; ES = -0.67, 90% CI = -1.52 to 0.17; PS = 68.2%) with a concomitant small increase of DHEA (p= 0.05; ES = 0.46, 90% CI = -0.38 to 1.29; PS = 62.7%). Conversely, the CG showed a moderate effect for increased DHEA and a small effect for increased cortisol after training. No significant interactions or main effects were shown for isometric handgrip values. Cooling vests diminished the cardiovascular strain and hormonal impact of the Judo training session in high-level athletes and may be considered for recovery purposes during exercise in warm/humid environments.

The purpose of this study was to compare biochemical and hormonal responses between mixed martial arts (MMA) competitors with minimal prefight weight loss and those undergoing rapid weight loss (RWL). Blood samples were taken from 17 MMA athletes (Mean± SD; age: 27.4 ±5.3yr; body mass: 76.2 ± 12.4kg; height: 1.71 ± 0.05m and training experience: 39.4 ± 25 months) before and after each match, according to the official events rules. The no rapid weight loss (NWL, n = 12) group weighed in on the day of the event (~30 min prior fight) and athletes declared not having used RWL strategies, while the RWL group (n = 5) weighed in 24 hr before the event and the athletes claimed to have lost 7.4 ± 1.1kg, approximately 10% of their body mass in the week preceding the event. Results showed significant (p < .05) increases following fights, regardless of group, in lactate, glucose, lactate dehydrogenase (LDH), creatinine, and cortisol for all athletes. With regard to group differences, NWL had significantly (p < .05) greater creatinine levels (Mean± SD; pre to post) (NWL= 101.6 ± 15–142.3 ± 22.9μmol/L and RWL= 68.9 ± 10.6–79.5 ± 15.9μmol/L), while RWL had higher LDH (median [interquartile range]; pre to post) (NWL= 211.5[183–236] to 231[203–258]U/L and RWL= 390[370.5–443.5] to 488[463.5–540.5]U/L) and AST (NWL= 30[22–37] to 32[22–41]U/L and 39[32.5–76.5] to 72[38.5–112.5] U/L) values (NWL versus RWL, p < .05). Post hoc analysis showed that AST significantly increased in only the RWL group, while creatinine increased in only the NWL group. The practice of rapid weight loss showed a negative impact on energy availability and increased both muscle damage markers and catabolic expression in MMA fighters.

The effect of altitude on soccer game activity profiles was retrospectively examined in six NCAA Division I female soccer players. Comparisons were made between two matches played at sea level (SL) and one match played at a moderate altitude (1839 m). A 10-Hz global positioning system device was used to measure distance and velocity. The rate of total distance capacity (TDC) and high intensity running (HIR) as well as percent of time at HIR were evaluated. Significant differences were seen in the distance rate (120.55 ± 8.26 m·min-1 versus 105.77 ± 10.19 m·min-1) and the HIR rate (27.65 ± 9.25 m·min-1 versus 25.07 ± 7.66 m·min-1) between SL and altitude, respectively. The percent of time at HIR was not significantly different (p = 0.064), yet tended to be greater at SL (10.4 ± 3.3%) than at altitude (9.1 ± 2.2%). Results indicate that teams residing at SL and competing at a moderate altitude may have a reduced ability in distance covered and a high intensity run rate.

The purpose of this study was to investigate the effects of short term resistance exercise on neuromuscular fatigue threshold (PWCFT), strength, functional performance, and body composition in older adults. Twenty-three participants (71.2 ± 6.0 yr) were randomly assigned to 6 weeks of resistance exercise (EXE) or control (CONT). A submaximal cycle ergometer test, physical working capacity at fatigue threshold, was used to determine PWCFT. Strength was assessed with predicted leg extension 1-RM and functional performance with time to complete 5 chair rises (CHAIR) and walk an 8-ft course (WALK). PWCFT, 1-RM and CHAIR significantly (p

To examine the efficacy of l-alanyl-l-glutamine ingestion with a commercially available sports drink compared to the sports drink only on time to exhaustion and physiological measures during prolonged endurance exercise.Twelve endurance-trained men (23.5 ± 3.7 years; 175.5 ± 5.4 cm; 70.7 ± 7.6 kg) performed 4 trials, each consisting of a 1-hour treadmill run at 75% VO2peak followed by a run to exhaustion at 90% VO2peak. One trial consisted of no hydration (NHY), another required ingestion of only a sports drink (ED), and 2 trials required ingestion of a low dose (LD; 300 mg·500 ml(-1)) and high dose (HD) of l-alanyl-l-glutamine (1 g·500 ml(-1)) added to the sports drink. During the fluid ingestion trials, 250 ml was consumed every 15 minutes. Plasma glutamine, glucose, electrolytes, and osmolality were measured prior to the run (PRE) and at 30, 45, and 60 minutes. VO2, respiratory quotient (RQ), and heart rate (HR) were measured every 15 minutes.Time to exhaustion was significantly longer during the LD and HD trials compared to NHY. No differences were noted in time to exhaustion between ED and NHY. Plasma glutamine concentrations were significantly elevated at 45 minutes in LD and HD trials and remained elevated at 60 minutes during HD. Sodium concentrations increased from the beginning of exercise and remained stable for the duration of the 1-hour run. At 60 minutes, plasma sodium was significantly lower in all trials compared to NHY.Results indicated that ingestion of the alanine-glutamine dipeptide at either the low or high dose significantly improved time to exhaustion during high-intensity exercise compared to a no-hydration trial.

Background Variations in institutional practice may contribute to different outcomes of cancer treatment. The impact of interinstitutional heterogeneity on outcomes between hospitals after oesophagectomy has not been examined previously using data from surgical clinical trials. Methods The data from two phase III trials for oesophageal cancer were used. Japan Clinical Oncology Group (JCOG) 9204 involved oesophagectomy (92-OP) versus oesophagectomy plus postoperative chemotherapy (92-POST), with accrual from 1992 to 1997. JCOG9907 involved postoperative chemotherapy (99-POST) versus preoperative chemotherapy (99-PRE), with accrual from 2000 to 2006. Hospitals contributing fewer than three patients were excluded. The influence of time and preoperative chemotherapy on interinstitutional heterogeneity related to postoperative complications and 5-year overall survival were evaluated by comparisons within and between these trial groups. Heterogeneity was estimated by a mixed-effects model after adjusting for age, sex, performance status, location of the primary tumour and clinical stage. Results Twelve hospitals in 92-OP (114 patients), 13 in 92-POST (114), 19 in 99-POST (158) and 18 in 99-PRE (154) were eligible. There was considerable heterogeneity in predicted postoperative complications in both groups in JCOG9204 (median 31·3 (range 15·0–68·2) per cent), and in 99-PRE (35·2 (22·6–46·6) per cent) but not in 99-POST (27·7 (27·7–27·7) per cent) from JCOG9907. A similar pattern was seen for predicted overall survival (92-POST: 66·4 (range 64·1–68·9) per cent; 99-PRE: 55·9 (54·0–59·7) per cent; 99-POST: 44·4 (44·4–44·4) per cent). Conclusion Interinstitutional heterogeneity regarding complications and survival after oesophagectomy is a problem that merits wider consideration.

To evaluate the time course of EMG frequency changes during a three-minute maximal effort cycling test (3MT) session and to examine which parameter between mean (MNF) and median (MDF) frequency is more suitable for evaluation of changes in neuromuscular function throughout a 3MT. Eighteen recreationally-active men volunteered to participate in this study. Maximum voluntary contraction (MVC) was measured using a dynamometer to determine maximal EMG frequency of the vastus lateralis (VL) of the kicking leg during isometric knee extension. A maximal oxygen consumption test (VO2peak) on a cycle ergometer was performed to establish the appropriate load profile for the 3MT which was completed after a period of at least 48 hours. MNF, MDF and power output (PO) values were measured at 10-second epochs throughout the duration of the 3MT. Repeated measures analysis of variance was used to compare the changes in EMG frequency, relative to maximal values from the MVC, and change in PO during the testing procedure. MNF, Root Mean Square (RMS), and PO significantly decreased during the 3MT, while MDF did not change significantly. Statistically, EMG frequency and PO decreased at first and remained constant in response to the 3MT, which may be reflective of differing patterns of muscle fiber type fatigue throughout the testing session. Due to decreased variability, changes in neuromuscular function during this protocol may be better evaluated using MNF than MDF.

This study compared caffeine pharmacokinetics, glycerol concentrations, metabolic rate, and performance measures following ingestion of a time-release caffeine containing supplement (TR-CAF) versus a regular caffeine capsule (CAF) and a placebo (PL). Following a double-blind, placebo-controlled, randomized, cross-over design, ten males (25.9 ± 3.2 y) who regularly consume caffeine ingested capsules containing either TR-CAF, CAF, or PL. Blood draws and performance measures occurred at every hour over an 8-hour period. Plasma caffeine concentrations were significantly greater (p < 0.05) in CAF compared to TR-CAF during hours 2-5 and significantly greater (p = 0.042) in TR-CAF compared to CAF at hour 8. There were no significant differences between trials in glycerol concentrations (p = 0.86) or metabolic measures (p = 0.17-0.91). Physical reaction time was significantly improved for CAF at hour 5 (p=0.01) compared to PL. Average upper body reaction time was significantly improved for CAF and TR-CAF during hours 1-4 (p = 0.04 and p = 0.01, respectively) and over the 8-hour period (p = 0.04 and p = 0.001, respectively) compared to PL. Average upper body reaction time was also significantly improved for TR-CAF compared to PL during hours 5-8 (p = 0.004). TR-CAF and CAF showed distinct pharmacokinetics yielding modest effects on reaction time, yet did not alter glycerol concentration, metabolic measures, or other performance measures.

Purpose:During the competitive soccer season, women’s intercollegiate matches are typically played on Friday evenings and Sunday afternoons. The efficacy of a 42-h recovery period is not well understood. This investigation was conducted to determine performance differences between Friday and Sunday matches during a competitive season.Methods:Ten NCAA Division I female soccer players (20.5 ± 1.0 y, 166.6 ± 5.1 cm, 61.1 ± 5.8 kg) were monitored with 10-Hz GPS devices across 8 weekends with matches played on Friday evenings and Sunday afternoons. The players were outside backs, midfielders, and forwards. All players had to participate in a minimum of 45 min/match to be included in the study. Average minutes played, total distance covered, total distance of high-intensity running (HIR) (defined as running at a velocity equal to or exceeding 3.61 m/s for longer than 1 s), the number of HIR efforts, and the number of sprints were calculated for each match. Data for Friday vs Sunday matches were averaged and then compared using dependent t tests.Results:No differences were seen in minutes played, distance rate, or number of sprints between Friday and Sunday matches. A significant (P = .017) decrease in rate of HIR between Friday (25.37 ± 7.22 m/min) and Sunday matches (22.90 ± 5.70 m/min) was seen. In addition, there was a trend toward a difference (P = .073) in the number of efforts of HIR between Friday (138.41 ± 36.43) and Sunday (126.92 ± 31.31).Conclusions:NCAA Division I female soccer players cover less distance of HIR in games played less than 48 h after another game. This could be due to various factors such as dehydration, glycogen depletion, or muscle damage.

The purpose of this study was to examine the effect of β-alanine (BA) ingestion on tissue carnosine levels and the impact such changes would have on combat specific activity. Eighteen soldiers (19.9 ± 0.8 year) from an elite combat unit were randomly assigned to either a BA or placebo (PL) group. Before and following a 30-day supplementation period carnosine content of the gastrocnemius muscle and brain was determined by proton magnetic resonance spectroscopy. During each testing session, participants performed military relevant tasks that included a 2.5 km run, a 1-min sprint, 50-m casualty carry, repeated 30-m sprints with target shooting, and a 2-min serial subtraction test (SST) to assess cognitive function under stressful conditions. A significant elevation (p = 0.048) in muscle carnosine content was noted in BA compared to PL. Changes in muscle carnosine content was correlated to changes in fatigue rate (r = 0.633, p = 0.06). No changes (p = 0.607) were observed in brain carnosine content. Following supplementation, no differences were noted in 2.5 km run, 1-min sprint, repeated sprint, or marksmanship performance, but participants in BA significantly (p = 0.044) improved their time for the 50-m casualty carry and increased their performance (p = 0.022) in the SST compared to PL. In summary, 30-days of BA ingestion can increase muscle carnosine content and improve aspects of military specific performance. Although cognitive performance was significantly greater in participants consuming BA compared to placebo, current study methods were unable to detect any change in brain carnosine levels, thus, the precise mechanism underlying these effects remains elusive.

Conflicting results have been documented in the Special Judo Fitness Test (SJFT) for mean parameters of performance between male and female judo athletes matched by age and competitive level. Therefore, it is debatable whether previously established norms for the SJFT prepared for men, should be adopted for use in women. The goal of this investigation was to prepare standards to allow coaches and researchers to control and evaluate training effects in female judoka. Systematic review was used to compile previously published scientific studies containing information on female judo athletes who were tested using the SJFT. The results were derived using meta-analysis and included data obtained from 11 relevant studies published between January 1997 and December 2013. Combined mean and SDs were computed based on studies containing 161 individual results from the SJFT. A 5° scale was adopted as follows: Excellent = highest 5%, Good = next highest 15%, Regular = middle 60%, Poor = next lowest 15%, and Very poor = lowest 5%. The results of the current investigation provide normative data for the SJFT for junior and senior female judoka. Classification for each of the parameters of the SJFT, including number of throws completed during the test, heart rate (HR) measured immediately after the effort, HR after a 1-minute recovery period and SJFT index, were established. This normative data can be used in the design of training programs for female judoka, as well as evaluation after training, and in preparation for competition.

We present a rigorous and comprehensive survey on extensions to the multicriteria setting of three well-known scalar optimization algorithms. Multiobjective versions of the steepest descent, the projected gradient and the Newton methods are analyzed in detail. At each iteration, the search directions of these methods are computed by solving real-valued optimization problems and, in order to guarantee an adequate objective value decrease, Armijo-like rules are implemented by means of a backtracking procedure. Under standard assumptions, convergence to Pareto (weak Pareto) optima is established. For the Newton method, superlinear convergence is proved and, assuming Lipschitz continuity of the objectives second derivatives, it is shown that the rate is quadratic

Purpose To evaluate the effects of moderate normobaric hypoxia on the parameters of the work-time relationship in the upper body. Methods Twenty-one recreationally active men completed a graded exercise test in both normobaric hypoxia (H) and normoxia (N) to exhaustion on an arm ergometer to determine VO2peak and peak power output (PPO). Each participant completed four constant work-rate (CWR) arm-cranking tests at 90–120% PPO in both environmental conditions. Linear regression was used to estimate critical power (CP) and anaerobic working capacity (AWC) via work-time relationship during the CWR tests. Results H significantly reduced VO2peak (N: 2.34 ± 0.34 L vs. H: 2.27 ± 0.34 L, p = 0.041), PPO (N: 125.29 ± 17.98 W vs. H: 121.11 ± 17.98 W, p = 0.001), and CP (N: 90.22 ± 12.88 W vs. H: 85.26 ± 9.64 W, p = 0.042), but had no effect on AWC (N: 9.16 ± 2.81 kJ vs. H: 8.75 ± 3.23 kJ, p = 0.600). Discussion Moderate normobaric hypoxia appears to reduce CP in the upper body but has a variable effect on AWC.

Tumor necrosis factor-alpha (TNF-α) has been shown to be implicated in both muscle regeneration and muscle wasting. However, it remains unclear whether TNF-α is responsible for the age-related losses in muscle size and function. Also, due to the high clearance rate of TNF-α from circulation, analyzing the circulating levels of soluble TNF-α receptors 1 and 2 (STNFR1 and STNFR2) may provide a better indication of inflammatory events. The aim of this study was to examine changes in circulating concentrations of TNF-α, STNFR1, and STNFR2 following acute eccentric exercise in young (YA) and middle-aged (MA) men.Nine YA (N=9, 21.8±2.2y, 179.5±4.9cm, 91.2±12.2kg, 21.8±4.3% body fat) and ten MA (N=10, 47.0±4.4y, 176.8±7.6cm; 96.0±21.5kg, 25.4±5.3% body fat) men completed an acute muscle damaging protocol (MDP). Blood samples were obtained at baseline (BL), immediately (IP), 30-minute (30P), 60-minute (60P), 120-minute (120P), 24-hour (24H), and 48-hour (48H) post-MDP. Lower body performance was assessed via isokinetic dynamometer at BL, IP, 120P, 24H, and 48H.YA displayed higher values of peak torque (p=0.023) and mean torque (p=0.036) at BL. No significant group differences were observed for markers of muscle damage or TNF-α. Plasma concentrations of TNF-α were unchanged following MDP. STNFR1 concentrations were significantly higher in the YA group compared to MA (p=0.036). Significant time effects were observed for STNFR1 (p0.001) and STNFR2 (p=0.001). With both groups combined, serum STNFR1 was decreased at 30P (p=0.001), while STNFR2 was decreased at 30P (p=0.008), 60P (p=0.003), and 120P (p=0.002) relative to BL.The pro-inflammatory response to muscle damage does not appear to decline at middle age when individuals are recreationally trained. However, young men showed significantly higher serum STNFR1 concentrations than middle age men. This may suggest that natural inhibitors of TNF-α decline as early as middle age.

β-Alanine (BA) supplementation results in elevated intramuscular carnosine content, enhancing buffering capacity during intense exercise. Although men have greater muscle carnosine content than women, elevations still appear to occur despite high baseline levels. Recent research has suggested that BA supplementation may also reduce muscle l-histidine. Thus, the purpose of this investigation was to compare 28 days of BA (6 g·d-1) supplementation in men and women on performance and muscle carnosine, l-histidine, and BA. We hypothesized that supplementation would result in similar elevations in carnosine and performance between sexes and decrease l-histidine. Twenty-six men and women were assigned either BA or placebo (PLA). At baseline, a trend toward greater carnosine (P = .069) was observed in men, and intramuscular BA content was significantly (P ≤ .05) greater in men. Statistical analysis was performed using magnitude-based inferences. Changes in muscle carnosine were likely and very likely greater after BA supplementation compared with PLA in men and women, respectively, but changes were unclear between sexes (mean sex difference: 2.50 ± 4.30 mmol·kg-1 ww). The attenuation of exercise fatigue was likely greater in BA compared with PLA, but the change was unclear between sexes (mean sex difference: 14.0 ± 39.0 Nm). Changes in muscle BA following supplementation was unclear in men, likely elevated in women, but unclear between sexes (mean sex difference: 0.03 ± 0.42 mmol·kg-1 ww). Changes in muscle l-histidine were unclear in men and women, and unclear between sexes (mean sex difference: 0.09 ± 0.13 mmol·kg-1 ww). In conclusion, BA supplementation increased muscle carnosine and attenuated fatigue in men and women similarly but did not reduce muscle l-histidine.

Heart rate deflection point (HRDP) can be determined through different mathematical-modeling procedures, such as bi-segmental linear regression (2SEG) or maximal distance model (Dmax). The purpose was to compare heart rate (HR) and oxygen consumption (VO2) at HRDP when using 2SEG and Dmax, and to examine their relationships with respiratory compensation point (RCP) and running performance. Nineteen participants completed a graded exercise test (GXT), to determine HRDP and RCP, and a 5km treadmill time trial (5Ktime). No differences were found in HR or VO2 when comparing HRDP2SEG, HRDPDmax, and RCP. Strong correlations were found between HRDP2SEG, HRDPDmax, and RCP when using HR and VO2. No relationships were found between 5Ktime and HR at HRDP or RCP; however, strong relationships were found with VO2. While 2SEG and Dmax may be interchangeable in determining HRDP, VO2 at HRDP and RCP yielded stronger relationships to 5Ktime than HR. Therefore, VO2 at HRDP may be a better predictor of running performance than HR.

Mental health conditions are common, disabling, potentially life-threatening, and costly; however, they are mostly treatable with early detection and intervention. Unfortunately, mental healthcare is in significantly short supply both nationally and locally, and particularly in small, rural, and relatively isolated communities. This article provides physicians and other health practitioners with a primer on the basic rationale and principles of integrating behavioral healthcare — particularly psychiatric specialty care — in primary care settings, including effective use of teleconferencing. Referring to a local-based example, this paper describes the programmatic components (universal screening, telephone availability, mutually educational team rounds, as-needed consultations, etc) that operationalize and facilitate successful primary care integration, and illustrates how these elements are applied to population segments with differing needs for behavioral healthcare involvement. Lastly, the article discusses the potential value of primary care integration in promoting quality, accessibility, and provider retention; discusses how new developments in healthcare financing could enhance the sustainability of primary care integration models; and summarizes lessons learned.

In this paper, we study augmented Lagrangian functions for nonlinear semidefinite programming (NSDP) problems with exactness properties. The term exact is used in the sense that the penalty parameter can be taken appropriately, so a single minimization of the augmented Lagrangian recovers a solution of the original problem. This leads to reformulations of NSDP problems into unconstrained nonlinear programming ones. Here, we first establish a unified framework for constructing these exact functions, generalizing Di Pillo and Lucidi's work from 1996, that was aimed at solving nonlinear programming problems. Then, through our framework, we propose a practical augmented Lagrangian function for NSDP, proving that it is continuously differentiable and exact under the so-called nondegeneracy condition. We also present some preliminary numerical experiments., 26 pages. Added journal reference

ABO and its paralogues, such as A3GALT2 and GGTA1, encoding α1,3-Gal(NAc) transferases, belong to the glycosyltransferase 6 (GT6) gene family. We have developed an alternative method for the identification of species based on sequence variations within the GT6 gene family, which is applicable to degraded DNA.DNA samples prepared from control mammalian species, together with an unknown sample, were polymerase chain reaction (PCR)-amplified using one universal primer pair targeting the sequences in the last coding exons of the GT6 gene family, yielding 141-bp products derived from those multiple loci. After cloning, sequence determination and Basic Local Alignment Search Tool analysis, phylogenetic trees were constructed.Comparison of the sequences obtained with those references showed good concordance with each of the starting species of mammals. This system was able to identify 'mouse' or 'rodent' as the origin of the unknown sample.For the identification of species, genotyping of ABO and its homologues would be applicable for the analysis of degraded DNA samples. Although the method employed in this study is likely valid for mammals, it would not be suitable for birds, fish and reptiles. It may be possible to improve the present method for use with other species by employing an alternative universal primer set.

Attenuating TNFα/TNFr1 signaling in monocytes has been proposed as a means of mitigating inflammation. The purpose of this study was to examine the effects of a milk protein supplement on TNFα and monocyte TNFr1 expression. Ten resistance-trained men (24.7 ± 3.4 years; 90.1 ± 11.3 kg; 176.0 ± 4.9 cm) ingested supplement (SUPP) or placebo (PL) immediately post-exercise in a randomized, cross-over design. Blood samples were obtained at baseline (BL), immediately (IP), 30-min (30P), 1-h (1H), 2-h (2H), and 5-h (5H) post-exercise to assess plasma concentrations of myoglobin; tumor necrosis factor-alpha (TNFα); and expression of tumor necrosis factor receptor 1 (TNFr1) on classical, intermediate, and non-classical monocytes. Magnitude-based inferences were used to provide inferences on the true effects of SUPP compared to PL. Plasma TNFα concentrations were “likely attenuated” (91.6% likelihood effect) from BL to 30P in the SUPP group compared with PL (d = 0.87; mean effect: 2.3 ± 2.4 pg mL−1). TNFr1 expressions on classical (75.9% likelihood effect) and intermediate (93.0% likelihood effect) monocytes were “likely attenuated” from BL to 2H in the SUPP group compared with PL (d = 0.67; mean effect: 510 ± 670 RFU, and d = 1.05; mean effect: 2500 ± 2300 RFU, respectively). TNFr1 expression on non-classical monocytes was “likely attenuated” (77.6% likelihood effect) from BL to 1H in the SUPP group compared with PL (d = 0.69; mean effect: 330 ± 430 RFU). Ingestion of a milk protein supplement immediately post-exercise appears to attenuate both plasma TNFα concentrations and TNFr1 expression on monocyte subpopulations in resistance-trained men.

Wang, R, Hoffman, JR, Sadres, E, Bartolomei, S, Muddle, TWD, Fukuda, DH, and Stout, JR. Evaluating upper-body strength and power from a single test: the ballistic push-up. J Strength Cond Res 31(5): 1338–1345, 2017—The purpose of this study was to examine the reliability of the ballistic push-up (BPU) exercise and to develop a prediction model for both maximal strength (1 repetition maximum [1RM]) in the bench press exercise and upper-body power. Sixty recreationally active men completed a 1RM bench press and 2 BPU assessments in 3 separate testing sessions. Peak and mean force, peak and mean rate of force development, net impulse, peak velocity, flight time, and peak and mean power were determined. Intraclass correlation coefficients were used to examine the reliability of the BPU. Stepwise linear regression was used to develop 1RM bench press and power prediction equations. Intraclass correlation coefficient's ranged from 0.849 to 0.971 for the BPU measurements. Multiple regression analysis provided the following 1RM bench press prediction equation: 1RM = 0.31 × Mean Force − 1.64 × Body Mass + 0.70 (R2 = 0.837, standard error of the estimate [SEE] = 11 kg); time-based power prediction equation: Peak Power = 11.0 × Body Mass + 2012.3 × Flight Time − 338.0 (R2 = 0.658, SEE = 150 W), Mean Power = 6.7 × Body Mass + 1004.4 × Flight Time − 224.6 (R2 = 0.664, SEE = 82 W); and velocity-based power prediction equation: Peak Power = 8.1 × Body Mass + 818.6 × Peak Velocity − 762.0 (R2 = 0.797, SEE = 115 W); Mean Power = 5.2 × Body Mass + 435.9 × Peak Velocity − 467.7 (R2 = 0.838, SEE = 57 W). The BPU is a reliable test for both upper-body strength and power. Results indicate that the mean force generated from the BPU can be used to predict 1RM bench press, whereas peak velocity and flight time measured during the BPU can be used to predict upper-body power. These findings support the potential use of the BPU as a valid method to evaluate upper-body strength and power.

Digital coherent technology is considered an attractive way of realizing both high-speed metro links and long distance transmissions. In metro areas, there is a strong demand for a smaller, faster transceiver module. This demand is mainly driven by the rapidly increasing data center interconnection traffic, where transmission capacity per faceplane is a key feature. Therefore, optical integration technology is desired. Since compensation in digital coherent technology is performed in the electrical or digital domain, users can deal with those optics performances that are not compensated for digitally. This means using a new material that cannot provide perfect characteristics but that is suitable for miniaturization and integration is possible. Silicon photonics (SiPh) is considered an attractive technology that would enable the significant miniaturization of optical circuits and be capable of optical integration with high manufacturability. While SiPh-based devices have begun to be deployed for very short or short reach links on the basis of direct detection technology, their digital coherent applications have recently been investigated in view of their integration capability. This paper describes recent progress on SiPh-based integrated optical devices for high-speed digital coherent transceivers targeting metro links. An optical modulator and receiver with related circuits have been integrated into a single SiPh chip. TEC-free operation under non-hermetic conditions and the direct attachment of optical fibers have both been realized. Very thin and small packaging with sufficient performance has been demonstrated by using the SiPh chip co-packaged with high-speed ICs.

Wang, R, Hoffman, JR, Sadres, E, Bartolomei, S, Muddle, TWD, Fukuda, DH, and Stout, JR. Effects of different relative loads on power performance during the ballistic push-up. J Strength Cond Res 31(12): 3411-3416, 2017-The purpose of this investigation was to examine the effect of load on force and power performance during a ballistic push-up. Sixty (24.5 ± 4.3 years, 1.75 ± 0.07 m, and 80.8 ± 13.5 kg) recreationally active men who participated in this investigation completed all testing and were included in the data analysis. All participants were required to perform a 1 repetition maximum bench press, and ballistic push-ups without external load (T1), with 10% (T2) and 20% (T3) of their body mass. Ballistic push-ups during T2 and T3 were performed using a weight loaded vest. Peak and mean force, power, as well as net impulse and flight time were determined for each ballistic push-up. Peak and mean force were both significantly greater (p < 0.01) during T3 (1,062 ± 202 and 901 ± 154 N, respectively), than both T2 (1,017 ± 202 and 842 ± 151 N, respectively) and T1 (960 ± 188 and 792 ± 140 N, respectively). Peak and mean power were significantly greater (p < 0.01) during T1 (950 ± 257 and 521 ± 148 W, respectively), than both T2 (872 ± 246 and 485 ± 143 W, respectively) and T3 (814 ± 275 and 485 ± 162 W, respectively). Peak and mean power were greatest during T1, regardless of participants' strength levels. Significant (p < 0.01) greater net impulse and smaller peak velocity and flight time were also noted from T1 to T3. Results of this investigation indicated that maximal power outputs were achieved without the use of an external load when performing the ballistic push-up, regardless of the participants' level of strength.

In this work we are interested in nonlinear symmetric cone problems (NSCPs), which contain as special cases nonlinear semidefinite programming, nonlinear second order cone programming and the classical nonlinear programming problems. We explore the possibility of reformulating NSCPs as common nonlinear programs (NLPs), with the aid of squared slack variables. Through this connection, we show how to obtain second order optimality conditions for NSCPs in an easy manner, thus bypassing a number of difficulties associated to the usual variational analytical approach. We then discuss several aspects of this connection. In particular, we show a "sharp" criterion for membership in a symmetric cone that also encodes rank information. Also, we discuss the possibility of importing convergence results from nonlinear programming to NSCPs, which we illustrate by discussing a simple augmented Lagrangian method for nonlinear symmetric cones. We show that, employing the slack variable approach, we can use the results for NLPs to prove convergence results, thus extending a special case (i.e., the case with strict complementarity) of an earlier result by Sun, Sun and Zhang for nonlinear semidefinite programs., 27 pages. To appear in Mathematics of Operations Research. In this version, an appendix with preliminary numerical experiments was added, the abstract was slightly changed, typos were corrected and the final part of the proof of Proposition 7.3 was also slightly changed. Comments are welcome

BACKGROUND This study aimed to analyze the acute effects of a judo training session on muscle strength, delayed-onset muscle soreness (DOMS), and serum creatine kinase (CK) activity. METHODS Ten male judo athletes participated in this study and performed a 90-min traditional judo training session. The following measurements were performed before and 48 hours after the training: shoulder external/internal rotation isokinetic torque, countermovement jump (CMJ), DOMS, and blood draw for serum CK analysis. Student's t-test with significance level set at 5% and, effect size analysis were used. RESULTS Significant reduction was found in jump height in the CMJ after the training session (2.9%; moderate effect; P=0.02). No significant differences were observed in any of the measures of shoulder external/internal rotation isokinetic torque (P>0.05). An increase of the serum CK (49.4%; moderate effect; P=0.01) and DOMS (20.6%; large effect; P=0.003) were noted after the training session when compared to baseline. CONCLUSIONS Judo training session resulted in increased serum CK activity, and muscle soreness. The decrease of CMJ performance indicates impairment in the lower-limbs muscle power production. However, the lack of difference of shoulder external/internal rotation torque before and 48 hours after the training session may indicate that the interval was enough to recover the upper-limbs strength in judokas of this study. These markers of muscle damage can be used to control muscle adaptation progress and to avoid sports-related disorders of athletes with similar characteristics to those evaluated in this study.

Currently, many space missions that use cryogenic equipment are being planned. In particular, high resolution sensors, such as transition edge sensors, require very low operating temperatures, below 100 mK. Adiabatic demagnetization refrigerator (ADR) systems are a useful tool for producing ultra-low temperatures in space because these devices can operate independently of gravity. The magnetic material is one of the most important components with respect to effectiveness of the cooling power. Thus, we could increase the cooling power using a magnetic material that has a large entropy change over the operating temperature range. Polycrystalline Gd 2 O 2 S (GOS), which was developed by Numazawa et al, can be used as such as a magnetic regenerator material. Furthermore, GOS has a very large specific heat and a magnetic phase transition temperature of about 5.2 K. These features make GOS suitable for use in the high temperature stage of an ADR. In this study, we measured and evaluated the physical properties of GOS for applications to ADRs.

To determine if unilateral measures of muscle architecture in the rectus femoris (RF) and vastus lateralis (VL) were related to (and predictive of) sprinting speed and unilateral (and bilateral) force (FRC) and power (POW) during a 30 s maximal sprint on the Woodway Curve 3.0 non-motorized treadmill. Twenty-eight healthy, physically active men (n = 14) and women (n = 14) (age = 22.9 ± 2.4 years; body mass = 77.1 ± 16.2 kg; height = 171.6 ± 11.2 cm; body-fa t = 19.4 ± 8.1%) completed one familiarization and one 30-s maximal sprint on the TM to obtain maximal sprinting speed, POW and FRC. Muscle thickness (MT), cross-sectional area (CSA) and echo intensity (ECHO) of the RF and VL in the dominant (DOM; determined by unilateral sprinting power) and non-dominant (ND) legs were measured via ultrasound. Pearson correlations indicated several significant (p < 0.05) relationships between sprinting performance [POW (peak, DOM and ND), FRC (peak, DOM, ND) and sprinting time] and muscle architecture. Stepwise regression indicated that POW(DOM) was predictive of ipsilateral RF (MT and CSA) and VL (CSA and ECHO), while POW(ND) was predictive of ipsilateral RF (MT and CSA) and VL (CSA); sprinting power/force asymmetry was not predictive of architecture asymmetry. Sprinting time was best predicted by peak power and peak force, though muscle quality (ECHO) and the bilateral percent difference in VL (CSA) were strong architectural predictors. Muscle architecture is related to (and predictive of) TM sprinting performance, while unilateral POW is predictive of ipsilateral architecture. However, the extent to which architecture and other factors (i.e. neuromuscular control and sprinting technique) affect TM performance remains unknown.

The purpose of this study was to examine the effect of the L-Alanyl-L-Glutamine dipeptide (AG) on cognitive function and reaction time (RT) following endurance exercise. Twelve male endurance athletes (23.5 ± 3.7 y; 175.5 ± 5.4 cm; 70.7 ± 7.6 kg) performed four trials, each consisting of running on a treadmill at 70% of VO2max for 1h, then at 90% of VO2max until exhaustion. One trial consisted of no hydration (DHY), another required ingestion of only a sports electrolyte drink (ED) and two trials required ingestion of a low dose (LD; 300 mg·500 ml(-1)) and high dose (HD) of AG (1 g·500ml(-1)) added to the ED. Cognitive function and reaction tests were administered pre- and post-exercise. Magnitude based inferences were used to analyze ∆ cognitive function and ∆ reaction test data. Results indicated that DHY had a possible negative effect on number of hits in a 60-sec reaction test compared to LD and HD, while ED appeared to have a negative effect compared to HD. Analysis of lower body quickness indicated that LD and HD were likely improved in comparison to DHY. Performance on the serial subtraction test appeared to be possibly better in ED than DHY, while other comparisons between groups regarding cognitive function were unclear. In conclusion, rehydrating with AG during submaximal exercise may maintain or enhance subsequent RT in upper and lower body activities compared to DHY. These same effects were not apparent when participants consumed ED.

ADAM J. WELLS, MS, DAVID H. FUKUDA, PhD, JAY R. HOFFMAN, PhD, ADAM M. GONZALEZ, MEd,ADAM R. JAJTNER, MS, JEREMY R. TOWNSEND, MS, GERALD T. MANGINE, MEd, MAREN S. FRAGALA, PhD, andJEFFREY R. STOUT, PhDInstitute of Exercise Physiology and Wellness, University of Central Florida (UCF), 4000 Central Florida Blvd Orlando, Florida, 32816,USAAccepted 21 February 2014ABSTRACT: Introduction: Variations in transverse point of mea-sure on the vastus lateralis (VL) may significantly affect therelationship between structure and function. The purpose of thisstudy was to compare changes in muscle architecture at 2commonly used points of measure (VL0 and VL5). Methods:Maximal strength (1-repetition maximum [1RM] barbell squat)and muscle architecture were assessed PRE and POST 15weeks of periodized resistance training. VL0 was 50% of thestraight line distance between the greater trochanter and lateralepicondyle of the femur. VL5 was 5cm medial to VL0. Results:Increases in 1RM strength (3.762.4 kg; P50.004) wereobserved. Changes in muscle thickness (MT) at VL5 were sig-nificantly greater than at VL0 (P50.006). Changes in strengthcorrelated with changes in muscle architecture at VL0 only (MT:r50.561; fascicle length: r50.503). Conclusions: Changes inmuscle architecture appear to occur in a non-homogeneousmanner.

The purpose of this randomized, cross-over design study was to examine the effect of three different muscle potentiation protocols on acute changes in muscle architecture and vertical jump performance. Eleven experienced, resistance trained men (25.2±3.6y) completed three potentiation squat protocols using moderate intensity (MI; 75%, 3 sets x 10 repetitions), high intensity (HI; 90%, 3 sets x 3 repetitions) and 100% (1RM; 1 set x 1repetition) of their 1RM. In addition, all participants completed a control session (CTL) in which no protocol was performed. During each testing session, muscle architecture and vertical jump testing were assessed at baseline (BL), 8min post (8P) and 20min post (20P) workout. Ultrasound measures included cross sectional area (CSA) and pennation angle (PANG) of both the rectus femoris (RF) and vastus lateralis (VL). Following each ultrasound measure, peak vertical jump power (PVJP) and mean (MVJP) power was assessed using an accelerometer. Magnitude based inferences were used to make comparisons between trials. The MI trial resulted in a likely greater increase from BL to 8P and 20P in RF-CSA and VL-CSA, while the HI trial resulted in a likely greater change from BL to 20P in both RF-CSA and VL-CSA. Meanwhile, changes in PVJP and MVJP for the MI trial was likely decreased at BL-8P and BL–20P, while the HI trial was shown to result in a likely or possible decrease compared to CTL at BL-8P and BL–20P, respectively. A likely negative relationship was observed between changes in VL-PANG and MVJP (r = -0.35; p , 0.018) at BL-8P, and between changes in PVJP and RF-CSA (r = -0.37; p , 0.014) at BL–20P. Results of this study were unable to demonstrate any potentiation response from the trials employed, however these protocols did result in acute muscle architectural changes.

The relationship between PWCFT and common measures used to assess sarcopenia in older adults were examined. Fifty-eight older adults [age: 71.1 ± 6.2 years; body mass index (BMI): 28.0 ± 5.4 kg/m2] completed the testing procedures. Sarcopenia-related body composition was measured by dual-energy X-ray absorptiometry and participants performed a discontinuous cycle ergometry test to determine PWCFT. Functionality assessments included maximal isometric grip strength (GRIP) and sit-to-stand (STS) repetitions in 30 s. Muscle quality (MQ) was defined as GRIP relative to appendicular lean soft tissue (ALM), while skeletal muscle index (SMI) was defined as ALM/height2. Pearson correlations were used to examine the relationships among dependent variables. PWCFT showed significant relationships with ALM (r = 0.57), SMI (r = 0.47), body fat percentage (BF%) (r = −0.50), GRIP (r = 0.49), and STS (r = 0.44). For follow-up analyses, study participants were categorized into low sarcopenia risk (n = 31) or high sarcopenia risk (n = 27) groups by SMI. Sarcopenia risk was associated with PWCFT [odds ratio (OR): 1.051, 95% confidence interval (CI): 1.016–1.087] and STS (OR: 1.305, CI: 1.060–1.607), but not GRIP (OR: 1.098, CI: 0.989–1.218). Using receiver–operator characteristic curve analysis, both PWCFT [area under the curve (AUC): 0.737, CI: 0.608–0.866, optimal cutoff: 37.5 W] and STS (AUC: 0.749, CI: 0.623–0.874, optimal cutoff: 12.5 repetitions) showed discriminative ability with regard to sarcopenia risk. The current data suggest that the neuromuscular fatigue threshold, as measured by PWCFT, is related to measures of body composition and function in older adults.

Introduction Sarcopenia is currently best described as an age-related decline in skeletal muscle mass and function. However, no consensus exists as to how to best quantify muscle function in older adults. The muscle quality index (MQI) was recently recommended as an ideal evidence-based assessment of functional status in older adults. Nevertheless, the usefulness of MQI to assess physical function is limited by whether it is reflective of muscle qualitative changes to an intervention. Thus, the purpose of this investigation was to determine whether MQI changes in response to resistance exercise training and detraining and how such changes correspond to other recommended measures of physical function proposed by suggested definitions of sarcopenia. Methods Twenty-five older adults (70.6 ± 6.1 y; BMI = 28.1 ± 5.4 kg · m− 2) completed a 6-week resistance training program in a wait-list controlled, cross-over design. MQI was determined as power output from timed sit to stand (STS), body mass, and leg length. Gait speed, hand grip strength, get-up-and-go and lean body mass (LBM) were evaluated before and after exercise training and detraining. MQI and functional changes to training and detraining were evaluated with repeated measures ANOVA and clinical interpretations of magnitude based inferences. Results Short term resistance training significantly and clinically improved MQI (203.4 ± 64.31 to 244.3 ± 82.92 W), gait time (1.85 ± 0.36 to 1.66 ± 0.27 s) and sit to stand performance (13.21 ± 2.51 to 11.05 ± 1.58 s). Changes in LBM and hand grip strength were not significant or clinically meaningful. De-training for 6-weeks did not result in significant changes in any measure from post-training performance.

The inflammatory response to muscle-damaging exercise requires monocyte mobilization and adhesion. Complement receptor type 3 (CR3) and macrophage inflammatory protein (MIP)-1β enables monocyte recruitment, adhesion, and subsequent infiltration into damaged muscle tissue. The purpose of this study was to examine the effects of cold water immersion (CWI) and/or β-hydroxy-β-methylbutyrate free acid (HMB-FA) on CR3 expression and MIP-1β concentration after four sets of up to 10 repetitions of squat, dead lift, and split squat exercises at 70–80% 1-repetition maximum. Thirty-nine resistance-trained men (22.2 ± 2.5 yr) were randomly divided into four groups: 1) placebo (PL), 2) HMB-FA, 3) HMB-FA-CWI, and 4) PL-CWI. The HMB-FA groups ingested 3 g/day, and CWI groups were submersed into 10–12°C water for 10 min after exercise. Blood was sampled at baseline (PRE), immediately post- (IP), 30 min post- (30P), 24 h post- (24P), and 48 h post (48P)-exercise. Circulating MIP-1β was assayed and CR3 expression on CD14+ monocytes was measured by flow cytometry. Without treatment, CR3 expression significantly elevated at 30P compared with other time points ( P = 0.030–0.047). HMB-FA significantly elevated the percentage of monocytes expressing CR3 between IP and 24P ( P = 0.046) and between IP and 48P ( P = 0.046). No time effect was observed for MIP-1β concentration. The recovery modalities showed to attenuate the rise in CR3 following exercise. Additionally, supplementation with HMB-FA significantly elevated the percentage of monocytes expressing CR3 during recovery. Although the time course that inflammatory responses are most beneficial remains to be determined, recovery modalities may alter immune cell mobilization and adhesion mechanisms during tissue recovery.

Background Locally advanced gastric cancer with extensive regional and/or para-aortic lymph node (PAN) metastases is typically unresectable and associated with poor outcomes. This study investigated the safety and efficacy of S-1 plus cisplatin followed by extended surgery with PAN dissection for gastric cancer with extensive lymph node metastasis. Methods Patients with gastric cancer with bulky lymph node metastasis along the coeliac artery and its branches and/or PAN metastasis received two or three 28-day cycles of S-1 plus cisplatin, followed by gastrectomy with D2 plus PAN dissection. The primary endpoint was the percentage of complete resections with clear margins in the primary tumour (R0 resection). A target sample size of 50 with one-sided α of 0·105 and β of approximately 0·2 corresponded to an expected R0 rate of 65 per cent and a threshold of 50 per cent. Results Between February 2005 and June 2007, 53 patients were enrolled, of whom 51 were eligible. The R0 resection rate was 82 per cent. Clinical and pathological response rates were 65 and 51 per cent respectively. The 3- and 5-year overall survival rates were 59 and 53 per cent respectively. During chemotherapy, grade 3/4 neutropenia occurred in 19 per cent and grade 3/4 non-haematological adverse events in 15·4 per cent. The incidence of grade 3/4 adverse events related to surgery was 12 per cent. There were no reoperations or treatment-related deaths. Conclusion For locally advanced gastric cancer with extensive lymph node metastasis, 4-weekly S-1 plus cisplatin followed by surgery including PAN dissection was safe and effective for some patients. Further investigation of this treatment strategy is warranted.

Mangine, GT, Hoffman, JR, Gonzalez, AM, Townsend, JR, Wells, AJ, Jajtner, AR, Beyer, KS, Boone, CH, Wang, R, Miramonti, AA, LaMonica, MB, Fukuda, DH, Witta, EL, Ratamess, NA, and Stout, JR. Exercise-induced hormone elevations are related to muscle growth. J Strength Cond Res 31(1): 45-53, 2017-Partial least squares regression structural equation modeling (PLS-SEM) was used to examine relationships between the endocrine response to resistance exercise and muscle hypertrophy in resistance-trained men. Pretesting (PRE) measures of muscle size (thickness and cross-sectional area) of the vastus lateralis and rectus femoris were collected in 26 resistance-trained men. Participants were randomly selected to complete a high-volume (VOL, n = 13, 10-12RM, 1-minute rest) or high-intensity (INT, n = 13, 3-5RM, 3-minute rest) resistance training program. Blood samples were collected at baseline, immediately postexercise, 30-minute, and 60-minute postexercise during weeks 1 (week 1) and 8 (week 8) of training. The hormonal responses (testosterone, growth hormone [22 kD], insulin-like growth factor-1, cortisol, and insulin) to each training session were evaluated using area-under-the-curve (AUC) analyses. Relationships between muscle size (PRE), AUC values (week 1 + week 8) for each hormone, and muscle size (POST) were assessed using a consistent PLS-SEM algorithm and tested for statistical significance (p ≤ 0.05) using a 1,000 samples consistent bootstrapping analysis. Group-wise comparisons for each relationship were assessed through independent t-tests. The model explained 73.4% (p < 0.001) of variance in muscle size at POST. Significant pathways between testosterone and muscle size at PRE (p = 0.043) and muscle size at POST (p = 0.032) were observed. The ability to explain muscle size at POST improved when the model was analyzed by group (INT: R = 0.882; VOL: R = 0.987; p < 0.001). No group differences in modal quality were found. Exercise-induced testosterone elevations, independent of the training programs used in this study, seem to be related to muscle growth.

Resistance exercise increases muscle mass by shifting protein balance in favor of protein accretion. Androgens independently alter protein balance, but it is unknown whether androgens alter this measure after resistance exercise. To answer this, male mice were subjected to sham or castration surgery 7–8 wk before undergoing a bout of unilateral, high-frequency, electrically induced muscle contractions in the fasted or refed state. Puromycin was injected 30 min before euthanasia to measure protein synthesis. The tibialis anterior was analyzed 4 h postcontraction. In fasted mice, neither basal nor stimulated rates of protein synthesis were affected by castration despite lower phosphorylation of mechanistic target of rapamycin in complex 1 (mTORC1) substrates [p70S6K1 (Thr389) and 4E-BP1 (Ser65)]. Markers of autophagy (LC3 II/I ratio and p62 protein content) were elevated by castration, and these measures remained elevated above sham values after contractions. Furthermore, in fasted mice, the protein content of Regulated in Development and DNA Damage 1 (REDD1) was correlated with LC3 II/I in noncontracted muscle, whereas phosphorylation of uncoordinated like kinase 1 (ULK1) (Ser757) was correlated with LC3 II/I in the contracted muscle. When mice were refed before contractions, protein synthesis and mTORC1 signaling were not affected by castration in either the noncontracted or contracted muscle. Conversely, markers of autophagy remained elevated in the muscles of refed, castrated mice even after contractions. These data suggest the castration-mediated elevation in baseline autophagy reduces the absolute positive shift in protein balance after muscle contractions in the refed or fasted states. NEW & NOTEWORTHY In the absence of androgens, markers of autophagy were elevated, and these could not be normalized by muscle contractions. In the fasted state, REDD1 was identified as a potential contributor to autophagy in noncontracted muscle, whereas phosphorylation of ULK1 may contribute to this process in the contracted muscle. In the refed state, markers of autophagy remain elevated in both noncontracted and contracted muscles, but the relationship with REDD1 and ULK1 (Ser757) no longer existed.

Background: The occurrence of peroneal neuropathy was reported to be higher in cancer patients than in non-cancer patients. Cancer patients should have their nutritional intake carefully managed in order to minimize weight loss and avoid the occurrence of peroneal neuropathy. However, the effect of nutrition support on the prevention of peroneal neuropathy is not understood. Aims: The present study aimed to assess epidemiologically the effect of nutrition support on the occurrence of peroneal neuropathy in cancer patients. Methods: We performed a retrospective case-control study in 178,597 cancer patients admitted to Shizuoka Cancer Center Hospital from 2002 to 2017. The rates of peroneal neuropathy were assessed between the 8-year period before nutrition support started and the 7-year period during which nutrition support performed. Results: Twenty-nine and 14 cases of peroneal neuropathy occurred in the periods without and with nutrition support, respectively. Compared with the period without nutrition support, the risk of peroneal neuropathy decreased by 62% during the period with nutrition support (odds ratio, 0.38; 95% confidence interval, 0.18-0.74; P < 0.05). Conclusion: Our study suggests the preventive effects of nutrition support on peroneal neuropathy in cancer patients.