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154. TCT-3 Modified Body Mass Index, A Novel Marker of Malnutrition and Clinical Frailty, is Associated With Outcomes After Transcatheter and Surgical Aortic Valve Replacement

Author

Driggin, Elissa, primary, Gupta, Aakriti, additional, Alu, Maria, additional, Liu, Mengdan, additional, Chen, Shmuel, additional, Kodali, Susheel, additional, Maurer, Matthew, additional, Thourani, Vinod, additional, Dvir, Danny, additional, Mack, Michael, additional, Leon, Martin, additional, and Green, Philip, additional

Published
2019
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155. Prevalence, Awareness, and Treatment of Isolated Diastolic Hypertension: Insights From the China PEACE Million Persons Project

Author

Mahajan, Shiwani, primary, Zhang, Danwei, additional, He, Siyun, additional, Lu, Yuan, additional, Gupta, Aakriti, additional, Spatz, Erica S., additional, Lu, Jiapeng, additional, Huang, Chenxi, additional, Herrin, Jeph, additional, Liu, Shuling, additional, Yang, Jingwei, additional, Wu, Chaoqun, additional, Cui, Jianlan, additional, Zhang, Qiuli, additional, Li, Xi, additional, Nasir, Khurram, additional, Zheng, Xin, additional, Krumholz, Harlan M., additional, Li, Jing, additional, Dong, Zhong, additional, Jiang, Bo, additional, Zhang, YingYi, additional, Liu, Yuhuan, additional, Meng, Yaqing, additional, Xi, Yunfeng, additional, Tian, Yuanmeng, additional, Fu, Yao, additional, Liu, Ting, additional, Yan, Shichun, additional, Jin, Lin, additional, Wang, Jing, additional, Xu, Xiaoling, additional, Xing, Xiuya, additional, Zhang, Luan, additional, Fang, Xin, additional, Xu, Yan, additional, Xu, Chunxiao, additional, Fan, Lei, additional, Qi, Minjie, additional, Qi, Junfeng, additional, Li, Junlin, additional, Liu, Qiong, additional, Feng, Yingqing, additional, Wang, Jiabin, additional, Wen, Hong, additional, Xu, Jie, additional, He, Jun, additional, Jiang, Chenxi, additional, Yang, Cangjiang, additional, Yu, Yue, additional, Tashi, Zongji, additional, Hu, Zhiping, additional, Zhang, Jing, additional, Li, Xiaoping, additional, Ma, Shaoning, additional, Ma, Yitong, additional, Huang, Ying, additional, Zhang, Yuchen, additional, and Shen, Jiacong, additional

Published
2019
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156. Impact of daily-supervised administration of a package of iron and folic acid and vitamin B12 on hemoglobin levels among adolescent girls (12-19 years): a cluster randomized control trial.

Author

Gupta, Aakriti, Kant, Shashi, Ramakrishnan, Lakshmy, Pandey, Ravindra Mohan, Khandelwal, Ritika, Kapil, Umesh, and Sachdev, Harshpal Singh

Subjects
VITAMIN therapy, IRON deficiency anemia prevention, RESEARCH, VITAMIN B12, HEMOGLOBINS, IRON, RESEARCH methodology, IRON in the body, EVALUATION research, DIETARY supplements, COMPARATIVE studies, RANDOMIZED controlled trials, IMPACT of Event Scale, RESEARCH funding, IRON deficiency anemia, FOLIC acid, STATISTICAL sampling
Abstract

Objective: The prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA) supplementation program. This study was conducted to assess the impact of daily supplementation of a package of IFA with vitamin B12 on hemoglobin levels among adolescent girls.Methods: A community-based cluster-randomized trial was conducted in the rural block of Faridabad District, Haryana, India in the year 2017. A total of 760 adolescent girls in the age group of 12-19 years with mild and moderate anemia were selected from government schools. Daily-supervised administration of iron and folic acid was conducted for 90 days: experimental group-IFA (iron (60 mg), folic acid (500) mcg), and cyanocobalamin (1000 mcg), control group-IFA and placebo. Hemoglobin, serum ferritin, and vitamin B12 levels were assessed at baseline and endline.Results: Two-hundred adolescent girls completed 90 doses of daily supplementation. The mean hemoglobin (experimental group: 1.3 ± 1.0 g/dL, control group: 1.6 ± 1.2 g/dL, P = 0.004) and ferritin levels (experimental group: 18.6 ± 31.5 ng/mL, control group: 18.8 ± 35.0 ng/mL, P = 0.188) increased in both the control and experiment groups. Serum vitamin B12 deficiency significantly reduced to 2.5% in the experimental group and ferritin deficiency alleviated in more than 96% of the girls post intervention.Conclusions: Daily supplementation of IFA with/without vitamin B12 for 90 days eliminated iron, vitamin B12 deficiency and reduced the overall proportion of anemia by 53.5%. However, addition of vitamin B12 to IFA supplementation had no impact on improving the hemoglobin levels among adolescent girls. The present study does not recommend provision of vitamin B12 for prevention and treatment of anemia in this population group. [ABSTRACT FROM AUTHOR]

Published
2021
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158. Intermediate-Dose versus Standard-Dose Prophylactic Anticoagulation in Patients with COVID-19 Admitted to the Intensive Care Unit: 90-Day Results from the INSPIRATION Randomized Trial

Author

Bikdeli, Behnood, Talasaz, Azita H., Rashidi, Farid, Bakhshandeh, Hooman, Rafiee, Farnaz, Rezaeifar, Parisa, Baghizadeh, Elahe, Matin, Samira, Jamalkhani, Sepehr, Tahamtan, Ouria, Sharif-Kashani, Babak, Beigmohammadi, Mohammad Taghi, Farrokhpour, Mohsen, Sezavar, Seyed Hashem, Payandemehr, Pooya, Dabbagh, Ali, Moghadam, Keivan Gohari, Khalili, Hossein, Yadollahzadeh, Mahdi, Riahi, Taghi, Abedini, Atefeh, Lookzadeh, Somayeh, Rahmani, Hamid, Zoghi, Elnaz, Mohammadi, Keyhan, Sadeghipour, Pardis, Abri, Homa, Tabrizi, Sanaz, Mousavian, Seyed Masoud, Shahmirzaei, Shaghayegh, Amin, Ahmad, Mohebbi, Bahram, Parhizgar, Seyed Ehsan, Aliannejad, Rasoul, Eslami, Vahid, Kashefizadeh, Alireza, Dobesh, Paul P., Kakavand, Hessam, Hosseini, Seyed Hossein, Shafaghi, Shadi, Ghazi, Samrand Fattah, Najafi, Atabak, Jimenez, David, Gupta, Aakriti, Madhavan, Mahesh V., Sethi, Sanjum S., Parikh, Sahil A., Monreal, Manuel, Hadavand, Naser, Hajighasemi, Alireza, Maleki, Majid, Sadeghian, Saeed, Piazza, Gregory, Kirtane, Ajay J., Van Tassell, Benjamin W., Stone, Gregg W., Lip, Gregory Y. H., Krumholz, Harlan M., Goldhaber, Samuel Z., and Sadeghipour, Parham

Published
2022
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166. Impact of daily-supervised administration of a package of iron and folic acid and vitamin B12on hemoglobin levels among adolescent girls (12–19 years): a cluster randomized control trial

Author

Gupta, Aakriti, Kant, Shashi, Ramakrishnan, Lakshmy, Pandey, Ravindra Mohan, Khandelwal, Ritika, Kapil, Umesh, and Sachdev, Harshpal Singh

Abstract

Objective: The prevalence of anemia has remained high among Indian adolescent girls over the past decade, despite the ongoing iron and folic acid (IFA) supplementation program. This study was conducted to assess the impact of daily supplementation of a package of IFA with vitamin B12on hemoglobin levels among adolescent girls. Methods: A community-based cluster-randomized trial was conducted in the rural block of Faridabad District, Haryana, India in the year 2017. A total of 760 adolescent girls in the age group of 12–19 years with mild and moderate anemia were selected from government schools. Daily-supervised administration of iron and folic acid was conducted for 90 days: experimental group—IFA (iron (60 mg), folic acid (500) mcg), and cyanocobalamin (1000 mcg), control group—IFA and placebo. Hemoglobin, serum ferritin, and vitamin B12levels were assessed at baseline and endline. Results: Two-hundred adolescent girls completed 90 doses of daily supplementation. The mean hemoglobin (experimental group: 1.3 ± 1.0 g/dL, control group: 1.6 ± 1.2 g/dL, P= 0.004) and ferritin levels (experimental group: 18.6 ± 31.5 ng/mL, control group: 18.8 ± 35.0 ng/mL, P= 0.188) increased in both the control and experiment groups. Serum vitamin B12deficiency significantly reduced to 2.5% in the experimental group and ferritin deficiency alleviated in more than 96% of the girls post intervention. Conclusions: Daily supplementation of IFA with/without vitamin B12for 90 days eliminated iron, vitamin B12deficiency and reduced the overall proportion of anemia by 53.5%. However, addition of vitamin B12to IFA supplementation had no impact on improving the hemoglobin levels among adolescent girls. The present study does not recommend provision of vitamin B12for prevention and treatment of anemia in this population group.

Published
2021
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168. Vitamin D and COVID-19.

Author

Bilezikian, John P., Bikle, Daniel, Hewison, Martin, Lazaretti-Castro, Marise, Formenti, Anna Maria, Gupta, Aakriti, Madhavan, Mahesh V., Nair, Nandini, Babalyan, Varta, Hutchings, Nicholas, Napoli, Nicola, Accili, Domenico, Binkley, Neil, Landry, Donald W., and Giustina, Andrea

Subjects
COVID-19, VITAMIN D, SARS-CoV-2, COVID-19 pandemic, ADULT respiratory distress syndrome
Abstract

The SARS-CoV-2 virus responsible for the COVID-19 pandemic has generated an explosion of interest both in the mechanisms of infection leading to dissemination and expression of this disease, and in potential risk factors that may have a mechanistic basis for disease propagation or control. Vi tamin D has emerged as a factor that may be involved in these two areas. The focus of this article is to apply our c urrent understanding of vitamin D as a facilitator of immunocompetence both with regard to innate and adaptive immuni ty and to consider how this may relate to COVID-19 disease. There are also intriguing potential links to vitamin D as a factor in the cytokine storm that portends some of the most serious consequences of SARS-CoV-2 infection, such as the acute respiratory distress syndrome. Moreover, cardiac and coagulopathic features of COVID-19 diseas e deserve attention as they may also be related to vitamin D. Finally, we review the current clinical data asso ciating vitamin D with SARS-CoV-2 infection, a putative clinical link that at this time must still be considered hypoth etical. [ABSTRACT FROM AUTHOR]

Published
2020
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169. Association of tobacco and alcohol consumption with cardiovascular risk factors among elderly population in India.

Author

Gupta, Aakriti, Belwal, Ravi, Ramakrishnan, Lakshmy, Khenduja, Preetika, and Kapil, Umesh

Subjects
*CARDIOVASCULAR diseases risk factors, *ALCOHOL drinking, *OLDER people, *HEALTH behavior, *TOBACCO
Abstract

Introduction: The present study was conducted to assess the association of tobacco and alcohol consumption with cardiovascular risk factors among elderly population living at high altitude regions of India. Materials and Methods: A cross-sectional study was conducted among 1003 elderly people living in district Nainital, Uttarakhand state, India. Thirty subjects were identified from 30 villages using population proportionate to size sampling methodology. The data on the consumption of tobacco and alcohol, mini nutritional assessment, Barthel activities of daily living scale, height, weight, blood pressure, fasting blood sugar, triglycerides, and total cholesterol was collected. Results: We found that smoking tobacco was associated with high cholesterol, lower body mass index, and low nutritional status (all, P < 0.05). Elderly subjects who consumed alcohol had 1.56 times higher risk of having high fasting blood glucose. Conclusions: Consumption of tobacco and alcohol increased the risk of cardiovascular diseases among elderly subjects. There is a need to improve these modifiable health behaviors through targeted educational and rehabilitation programs. [ABSTRACT FROM AUTHOR]

Published
2020
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170. P1-19-03 - Epidemiological Determinants of Malnutrition Status among Geriatric Population Residing at High Altitude Region of Rural Uttarakhand, India

Author

Gupta, Aakriti

Abstract

Background : High prevalence of Malnutrition exists amongst the geriatric population in India. Evidence on malnutrition is available from the plain regions of the country. However there is lack of scientific evidence on malnutrition status of geriatric population residing at high altitude regions of Uttarakhand, India.Materials and methods:A community based cross-sectional study was conducted during 2015-2016 in District Nainital. Thirty clusters were identified using population proportionate to size sampling method; 30 geriatric subjects were selected from each cluster. Study population included 980 geriatric aged 60 years and above. Nutritional status of the geriatric population was assessed using Mini Nutritional Assessment (MNA) tool. Standard procedures were used to determine the height, weight, MCC and MUAC. The BMI was calculated from the measurements of weight (kg) and height (cm) (kg/m2). Data was entered in MS Excel 2007 and analyzed using SPSS version 20.0.Results: The MNA revealed that only 22.4% geriatric subjects had satisfactory nutritional status, 14.3% were malnourished and 63.3% were u201cat risku201d of malnutrition. High prevalence of malnutrition was found among subjects belonging to age group of 60-70 years (58.9%), illiterate (74.5%) with family monthly income (1866-5546;43.3%), financially dependent (75.2%), with loss of appetite (71.6%), with chewing problem (63.1%) and who consumed

Published
2017

171. Pharmacological Agents Targeting Thromboinflammation in COVID-19: Review and Implications for Future Research.

Author

Bikdeli, Behnood, Madhavan, Mahesh V., Gupta, Aakriti, Jimenez, David, Burton, John R., Der Nigoghossian, Caroline, Chuich, Taylor, Nouri, Shayan Nabavi, Dreyfus, Isaac, Driggin, Elissa, Sethi, Sanjum, Sehgal, Kartik, Chatterjee, Saurav, Ageno, Walter, Madjid, Mohammad, Guo, Yutao, Tang, Liang V., Hu, Yu, Bertoletti, Laurent, and Giri, Jay

Published
2020
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173. Prospective audit of sedation/anesthesia practices for children undergoing computerized tomography in a tertiary care institute.

Author

Gupta, Aakriti, Sen, Indu, Bhardwaj, Neerja, Yaddanapudi, Sandhya, Mathew, Preethy, Sahni, Neeru, and Bhatia, Anmol

Subjects
*COMPUTED tomography, *TERTIARY care, *BUTORPHANOL, *ANESTHESIA, *ADVERSE health care events, *DRUG efficacy
Abstract

Background and Aims: The aim of the study was to enumerate the sedative drugs used, assess the efficacy of sedative drugs, and determine the incidence of adverse events. Material and Methods: A prospective audit of children sedated for computerized tomography (CT) by anesthesiology team was conducted for a period of 4 months. The data included patient demographic variables, fasting period, medications administered, adequacy of sedation, imaging characteristics, adverse events, and requirement for escalated care. Results: A total of 331 children were enrolled for sedation by the anesthesia team. The drugs used for sedation were propofol, ketamine, and midazolam. Twenty-two percent children received one sedative drug, 60% children were administered two drugs, and 5% children required a combination of all three drugs for successful sedation. Sedation was effective for successful conduct of CT scan in 95.8% patients without the requirement of a repeat scan. Twelve (5%) children experienced adverse events during the study period. However, none of the adverse events necessitated prolonged postprocedural hospitalization or resulted in permanent neurologic injury or death. Conclusions: The current practice of sedation with propofol, ketamine, and midazolam, either single or in combination was efficacious in a high percentage of patients. The incidence of adverse events during the study period was low. [ABSTRACT FROM AUTHOR]

Published
2020
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174. Risk factors of anemia amongst elderly population living at high-altitude region of India.

Author

Gupta, Aakriti, Ramakrishnan, Lakshmy, Pandey, Ravindra, Sati, Hem, Khandelwal, Ritika, Khenduja, Preetika, and Kapil, Umesh

Subjects
*ANEMIA, *MUSCLE mass, *BODY mass index, *FILTER paper, *HEALTH facilities
Abstract

Introduction: Anemia is a major public health problem amongst elderly population in India. Anemia in old age further worsens the age-related decline in functional ability, mobility, fatigue, bone density, and skeletal muscle mass. There is lack of evidence on the prevalence and risk factors of anemia among elderly population. Hence, this study was undertaken. Methodology: A community-based cross-sectional study was conducted during the year 2015–2016 in District Nainital, Uttarakhand state, India. A total of 958 subjects were selected from 30 clusters (villages) identified using population proportional to size methodology. Information on sociodemographic profile, nutritional status, body mass index, and dietary intake was obtained. Blood sample was collected from each subject on the filter paper for estimation of hemoglobin (Hb) level using cyanmethemoglobin method. Results: We found that 92.1% of the elderly subjects were anemic. Moderate and severe anemia was found to be significantly higher among female subjects, unemployed, illiterates, subjects using smoke-producing fuel, subjects belonging to lower socioeconomic status, malnourished and underweight subjects, subjects with self-reported hyperacidity, and subjects who had not utilized health facility and had lower iron and vitamin C intake when compared with subjects with mild anemia and normal hemoglobin levels. Conclusion: High prevalence of anemia exists amongst elderly subjects living at high-altitude region of rural Uttarakhand State, India. There is a need to educate the elderly population about the importance of adequate intake of foods rich in iron and vitamin C to reduce the prevalence of anemia among them. [ABSTRACT FROM AUTHOR]

Published
2020
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176. Association of Racial and Socioeconomic Disparities With Outcomes Among Patients Hospitalized With Acute Myocardial Infarction, Heart Failure, and Pneumonia

Author

Downing, Nicholas S., primary, Wang, Changqin, additional, Gupta, Aakriti, additional, Wang, Yongfei, additional, Nuti, Sudhakar V., additional, Ross, Joseph S., additional, Bernheim, Susannah M., additional, Lin, Zhenqiu, additional, Normand, Sharon-Lise T., additional, and Krumholz, Harlan M., additional

Published
2018
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183. Sex Differences in Timeliness of Reperfusion in Young Patients With ST‐Segment–Elevation Myocardial Infarction by Initial Electrocardiographic Characteristics

Author

Gupta, Aakriti, primary, Barrabes, Jose A., additional, Strait, Kelly, additional, Bueno, Hector, additional, Porta‐Sánchez, Andreu, additional, Acosta‐Vélez, J. Gabriel, additional, Lidón, Rosa‐Maria, additional, Spatz, Erica, additional, Geda, Mary, additional, Dreyer, Rachel P., additional, Lorenze, Nancy, additional, Lichtman, Judith, additional, D'Onofrio, Gail, additional, and Krumholz, Harlan M., additional

Published
2018
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188. Prevalence of pediatric metabolic syndrome and associated risk factors among school-age children of 10–16 Years living in District Shimla, Himachal Pradesh, India

Author

Kapil, Umesh, primary, Gupta, Anmol, additional, Sachdeva, Amit, additional, Mahajan, Narender, additional, Gupta, Aakriti, additional, Sareen, Neha, additional, Pandey, RavindraMohan, additional, Ramakrishnan, Lakshmy, additional, Sati, HemChandra, additional, Sharma, Brij, additional, and Sharma, Neetu, additional

Published
2018
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190. Comparison of Electrocardiographic Characteristics in Men Versus Women ≤ 55 Years With Acute Myocardial Infarction (a Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction Patients Substudy)

Author

Barrabés, José A., primary, Gupta, Aakriti, additional, Porta-Sánchez, Andreu, additional, Strait, Kelly M., additional, Acosta-Vélez, J. Gabriel, additional, D'Onofrio, Gail, additional, Lidón, Rosa-Maria, additional, Geda, Mary, additional, Dreyer, Rachel P., additional, Lorenze, Nancy P., additional, Lichtman, Judith H., additional, Spertus, John A., additional, Bueno, Héctor, additional, and Krumholz, Harlan M., additional

Published
2017
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193. Characterisation of anaemia amongst school going adolescent girls in rural Haryana, India – CORRIGENDUM.

Author

Gupta, Aakriti, Sachdev, Harshpal Singh, Kapil, Umesh, Prakash, Shyam, Pandey, Ravindra Mohan, Sati, Hem Chandra, Sharma, Lokesh Kumar, and Lal, Priti Rishi

Subjects
*TEENAGE girls, *ANEMIA
Abstract

Characterisation of anaemia amongst school going adolescent girls in rural Haryana, India - CORRIGENDUM In the published article, the authors overlooked mentioning that 0.5g/dl was added to the original hemoglobin values to correct for the difference using direct and indirect cyanmethaemoglobin method. Characterisation of anaemia amongst school going adolescent girls in rural Haryana, India. [Extracted from the article]

Published
2023
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194. Post-acute COVID-19 syndrome

Author

Nalbandian, Ani, Sehgal, Kartik, Gupta, Aakriti, Madhavan, Mahesh V., McGroder, Claire, Stevens, Jacob S., Cook, Joshua R., Nordvig, Anna S., Shalev, Daniel, Sehrawat, Tejasav S., Ahluwalia, Neha, Bikdeli, Behnood, Dietz, Donald, Der-Nigoghossian, Caroline, Liyanage-Don, Nadia, Rosner, Gregg F., Bernstein, Elana J., Mohan, Sumit, Beckley, Akinpelumi A., Seres, David S., Choueiri, Toni K., Uriel, Nir, Ausiello, John C., Accili, Domenico, Freedberg, Daniel E., Baldwin, Matthew, Schwartz, Allan, Brodie, Daniel, Garcia, Christine Kim, Elkind, Mitchell S. V., Connors, Jean M., Bilezikian, John P., Landry, Donald W., and Wan, Elaine Y.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen responsible for the coronavirus disease 2019 (COVID-19) pandemic, which has resulted in global healthcare crises and strained health resources. As the population of patients recovering from COVID-19 grows, it is paramount to establish an understanding of the healthcare issues surrounding them. COVID-19 is now recognized as a multi-organ disease with a broad spectrum of manifestations. Similarly to post-acute viral syndromes described in survivors of other virulent coronavirus epidemics, there are increasing reports of persistent and prolonged effects after acute COVID-19. Patient advocacy groups, many members of which identify themselves as long haulers, have helped contribute to the recognition of post-acute COVID-19, a syndrome characterized by persistent symptoms and/or delayed or long-term complications beyond 4 weeks from the onset of symptoms. Here, we provide a comprehensive review of the current literature on post-acute COVID-19, its pathophysiology and its organ-specific sequelae. Finally, we discuss relevant considerations for the multidisciplinary care of COVID-19 survivors and propose a framework for the identification of those at high risk for post-acute COVID-19 and their coordinated management through dedicated COVID-19 clinics.

Published
2021
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195. Correspondence

Author

Jain, Vandana, primary, Kabra, Madhulika, additional, Pan, Pradyumna, additional, Nema, Rajnish, additional, Kumar, Jogender, additional, Singh, Amitabh, additional, Upadhyay, Amit, additional, Tomar, Priya, additional, Gupta, Aakriti, additional, Kapil, Umesh, additional, Radhakrishnan, Nita, additional, Rai, Ruchi, additional, Kamate, Mahesh, additional, Maria, Arti, additional, Verma, Ankit, additional, Prashanth, G. P., additional, Fass, Uwe Werner, additional, Siddiqui, Shahid Akhtar, additional, and Shrivastava, Anubha, additional

Published
2017
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196. Research Letters

Author

Geeta, M. G., primary, Krishnakumar, P., additional, Gupta, Aakriti, additional, and Kapil, Umesh, additional

Published
2017
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