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The concept of integration of sports and education is the overall planning and top-level design of China's education and sports work in the new era, which has an important guiding role in the reform of school sports in China. In the context of the integration of sports and education, this paper examines the current situation of football professional training in six ordinary undergraduate colleges in China, and provides reference for the development of Chengdu University of Technology's football program and the entire sports specialty. The focus of the transformation of ideas for the training of football professionals in colleges and universities lies in how to manage to govern, establish a staggered governance of sharing interests and responsibilities, and ensure the innovation of the operation guarantee system in terms of policies, systems and funds. It provides reference for the development of curve overtaking in the School of Physical Education of Chengdu University of Technology. The College of Physical Education of Chengdu University of Technology should integrate existing resources in combination with its own school running conditions to provide effective assistance for accelerating the construction of a new development pattern of the world's "double first-class" higher education schools of Chengdu University of Technology. Keywords: Integration of sports and education; Football; Development mechanism; Talent cultivation. Title: Relevant problems and optimized development path of football major macro development mechanism talent training in Chengdu University of Technology Physical Education University under the background of integration of sports and education Author: Yu Xiang, Zhao Gang, Zhang Fucheng, Zhang Huiying, Wang Yue, Guo Si International Journal of Recent Research in Social Sciences and Humanities (IJRRSSH) ISSN 2349-7831 Vol. 9, Issue 4, October 2022 - December 2022 Page No: 66-74 Paper Publications Website: www.paperpublications.org Published Date: 27-October-2022 DOI: https://doi.org/10.5281/zenodo.7257772 Paper Download Link (Source) https://www.paperpublications.org/upload/book/Relevant%20problems%20and%20optimized-27102022-1.pdf, International Journal of Recent Research in Social Sciences and Humanities (IJRRSSH), ISSN 2349-7831, Paper Publications, Website: www.paperpublications.org

Studies showed that the increase of myeloid‐derived suppressor cells (MDSCs) in tumour microenvironment is closely related to the resistant treatment and poor prognosis of metastatic breast cancer. However, the effect of tumour‐derived exosomes on MDSCs and its mechanism are not clear. Here, we reported that breast cancer cells (4T1)‐secreted exosomes (BCC‐Ex) were able to differentiate bone marrow cells into MDSCs and significantly inhibited the proliferation of T lymphocytes to provide an immunosuppressive microenvironment for cancer cells in vivo and in vitro. The number of MDSCs in bone marrow and spleen of 4T1 tumour‐bearing mice and BCC‐Ex infused mice was significantly higher than that of normal mice, whereas the number of T lymphocytes in spleen was significantly decreased. In addition, BCC‐Ex markedly promoted the differentiation of MDSCs from bone marrow cells or bone marrow cells derived macrophages, seen as the increased expressions of MDSCs‐related functional proteins Arginase‐1 (Arg‐1) and inducible nitric oxide synthase (iNOS). Furthermore, BCC‐Ex significantly down‐regulated the expressions of chemokine receptor CXCR4 and markedly up‐regulated the levels of inflammatory cytokines IL‐6 and IL‐10 in bone marrow cells and macrophages and remarkably inhibited the division and proliferation of T cells. Importantly, CXCR4 agonist, CXCL12, could reverse the function of BCC‐Ex, indicating that BCC‐Ex‐induced MDSCs might be dependent on the down‐regulation of CXCR4. Western blot showed that BCC‐Ex significantly promoted the phosphorylation of STAT3 in bone marrow cells, resulting in the inhibitions of the proliferation and apoptosis of bone marrow cells, and the aggravation of the differentiation of bone marrow cells into MDSCs.

To enhance biotin production in Escherichia coli by engineering a heterologous biotin synthetic pathway. Biotin operon genes from Pseudomonas putida, which consisted of a bioBFHCD cluster and a bioA gene, was engineered into Escherichia coli for biotin production. The introduction of bioW gene from Bacillus subtilis, encoding pimeloyl-CoA synthetase and sam2 gene from Saccharomyces cerevisiae, encoding S-adenosyl-L-methionine (SAM) synthetase contributed to the heterologous production of biotin in recombinant E. coli. Furthermore, biotin production was efficiently enhanced by optimization of the fermentation compositions, especially pimelic acid and L-methionine, the precursor related to the pimeloyl-CoA and SAM synthesis, respectively. The combination of overexpression of the heterologous biotin operon genes and enhanced supply of key intermediate pimeloyl-CoA and SAM increased biotin production in E. coli by more than 121-fold. With bioprocess engineering efforts, biotin was produced at a final titer of 92.6 mg/L in a shake flask and 208.7 mg/L in a fed-batch fermenter. Through introduction of heterologous biotin synthetic pathway, increasing the supply of precursor pimeloyl-CoA and cofactor SAM can significantly enhance biotin production in E. coli.

In this article, a new power switch open-circuit fault diagnosis approach is proposed for the six-phase fault-tolerant permanent magnet synchronous motor (FTPMSM) system based on average current Park's vector (ACPV), which can detect the fault power switch for the FTPMSM system in both normal and phase open-circuit/short-circuit fault-tolerant operation conditions. To detect the power switch open-circuit fault, the fault detection approach based on the moduli of the ACPV in two orthogonal subspaces is first proposed for the six-phase FTPMSM system even in phase open-circuit and short-circuit fault-tolerant operation. Then, the ACPV-based fault location approach is proposed, which can identify the fault power switch according to the sign symbol of the ACPV. The resulting fault diagnosis approach has a simple structure and low computation burden, which can detect the power switch open-circuit fault online for the FTPMSM system in both normal and fault-tolerant operation conditions. Finally, the effectiveness of the proposed fault diagnosis approach is demonstrated by a six-phase FTPMSM system experimental platform.

Asia is the largest and most populous continent of Earth with an overall population of 446.27 crores. Housing this population drives various challenges in different aspects, in which providing healthy and nutritious food to each and every individual is most challenging. Unfortunately, because of certain production issues, farmers are not getting the desired throughput, and in some critical cases, situations lead to suicide. On the other hand, proper storage and distribution of these harvests are other challenges. Various models and IoT (internet of things)-based approaches have been presented and are available for implementation, but a dedicated layout combining the digitization of all the essential steps, starting from preparation of soil for agriculture to the making food available for every needy person, is still missing. In the paper, various related models have been studied, and an integral model is presented where integration of IoT is carried out with agriculture and with the food storage and distribution system.

Heavy Majorana neutrinos beyond the standard model can simultaneously explain the origin of tiny neutrino masses and matter-antimatter asymmetry in our Universe. The existence of heavy Majorana neutrinos will also lead to lepton number violation and the rare lepton-number-violating $W$ decays are possible. With contributions from two different Majorana neutrinos, a nonzero CP asymmetry may be generated from the rate difference between $W$ decay and its CP-conjugate process. The aim of this paper is to investigate the prospects for measuring CP violation in rare $W$ decays via Majorana neutrinos at the LHC. Our calculations show that the induced CP asymmetry is independent of the Majorana neutrino mass for $10~ \rm GeV < m_N < 70 ~\rm GeV$. Such a CP asymmetry if observed, would in turn provide unambiguous evidence of new physics beyond the standard model., 15 pages,6 Figures, 1 Table

The quark model symmetry can be adopted to establish relations between the low-energy constants (LECs) in the baryon chiral perturbation theory ($\chi PT$) if one assumes that a baryon-baryon-meson coupling is described equivalently by a quark-quark-meson coupling at the quark level. Through the correspondence between the $SU(2)$ description and the $SU(3)$ description for the same coupling vertex at the quark level, we find some relations between the LECs in $SU(2)_{\chi PT}$ and $SU(3)_{\chi PT}$ up to the third chiral order. The $SU(3)_{\chi PT}$ LEC relations at the same order are also obtained. The numerical analysis roughly supports these relations. In the situation that the available experimental data are not enough, one may employ such constraints to reduce the number of LECs., Comment: Version to appear in PRD. 16 pages, 2 figures, 7 tables