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151. LIST OF CONTRIBUTORS

Author

ABELL, C.W., primary, ALFORD, ROBERT H., additional, ALTER, B.J., additional, ANDERSON, A.O., additional, ANDERSON, DEBORAH J., additional, ANDERSON, SUSAN M., additional, ANDRON, L.A., additional, ANTON, ELIZABETH, additional, ARALA-CHAVES, M.P., additional, ARNON, R., additional, ASCHER, M.S., additional, BACH, F.H., additional, BAIRD, LYNN G., additional, BARCINSKI, MARCELLO A., additional, BARKER, BARBARA E., additional, BARTH, ROLF F., additional, BATTISTO, JACK R., additional, BELL, CLARA, additional, BEN-SASSON, SHMUEL A., additional, BERKE, GIDEON, additional, BERNHEIM, JAN L., additional, BESSLER, WOLFGANG G., additional, BETEL, IDO, additional, BETZ, SALLY J., additional, BEYER, C.F., additional, BLAESE, R. MICHAEL, additional, BLANKWATER, M.J., additional, BOCHERT, G., additional, BOCKMAN, D.E., additional, BOLDT, DAVID H., additional, BONA, CONSTANTIN, additional, BONAVIDA, BENJAMIN, additional, BONNARD, GUY D., additional, BOREL, J.F., additional, BOWERS, W.E., additional, BRAATZ, J.A., additional, BRADLEY, B., additional, BRADLEY, B.A., additional, BRAUNSTEINER, HERBERT, additional, BRODER, S., additional, BROWN, JOHN M., additional, BUNDY, BONITA M., additional, BURGER, D.R., additional, CAMBELL, D.A., additional, CARPENTER, C.B., additional, CASTAGNOLA, JAN, additional, CAVILES, ALENDRY P., additional, CHAKRAVARTY, A.K., additional, CHAPLIN, D.D., additional, CHARMOT, D., additional, CHISARI, F.V., additional, CLARK, W.R., additional, CLEMENTS, PHILIP J., additional, COHEN, I.R., additional, COOPER, HERBERT L., additional, COOPER, M.D., additional, COOPER, R.A., additional, CORLEY, RONALD B., additional, CROSIER, P., additional, CUNNINGHAM-RUNDLES, S., additional, CURTISS, LINDA K., additional, DANIELE, RONALD P., additional, DARAI, G., additional, DAUSSET, J., additional, DAVID, JOHN R., additional, DAYNES, RAYMOND A., additional, DEAN, JACK H., additional, DEBATES, MARY JO, additional, DECKER, JEAN M., additional, DE GOEDE, R.E.Y, additional, DEHEER, DAVID H., additional, DELFRAISSY, J.F., additional, DEWOLF, W.C., additional, DOOLEY, N.D., additional, DOOLEY, NANCY J., additional, DORIAN, RANDEL, additional, DORMONT, J., additional, DOUGLAS, GARY N., additional, DRAY, SHELDON, additional, DUPONT, B., additional, DURM, M., additional, DWYER, JOHN M., additional, EDGINGTON, THOMAS S., additional, ELFERINK, DIENNE, additional, ENDRES, ROBERT O., additional, ESSELMAN, WALTER J., additional, FAGAN, G., additional, FARNES, PATRICIA, additional, FAUCI, ANTHONY S., additional, FERGUSON, RONALD M., additional, FERRARINI, M., additional, FLETCHER, MARK P., additional, FRELINGER, JEFFREY A., additional, FORSDYKE, D.R., additional, FROST, A.F., additional, FUDENBERG, H. HUGH, additional, GALANAUD, P., additional, GAROVOY, M.R., additional, GARRIDO, F., additional, GEHA, RAIF S., additional, GEMSA, DIETHARD, additional, GEORGE, K., additional, GERSHWIN, M. ERIC, additional, GLICKMAN, E., additional, GOLDBLUM, R.M., additional, GOLDMAN, C., additional, GOLDSTEIN, ALLAN L., additional, GOOD, R.A., additional, GORDON, DAVID S., additional, GORDON, G., additional, GORDON, IAN L., additional, GORDON, JULIUS, additional, GORENBERG, DAVID J., additional, GORSKA, R., additional, GORSKI, A.J., additional, GOTTLIEB, M.N., additional, GRANBERG, CHRISTER, additional, GRANGER, GALE A., additional, GRAYBILL, J. RICHARD, additional, GREY, HOWARD M., additional, GRILLOT-COURVALIN, C., additional, GRIMM, ELIZABETH ANN, additional, GRINWICH, KAZIMIERA, additional, GROSSI, C.E., additional, GüNTHER, EBERHARD, additional, GUERRY, D., additional, HAMILL, BARBARA, additional, HANSEN, J.A., additional, HANTKE, KLAUS, additional, HAYWARD, A.R., additional, HEININGER, D., additional, HELDERMAN, J. HAROLD, additional, HENKART, PIERRE A., additional, HENNEY, CHRISTOPHER H., additional, HERBERMAN, R.B., additional, HESTER, RAYMOND B., additional, HIRSCHBERG, HENRY, additional, HISERODT, JOHN C., additional, HOETTE, M., additional, HOLIMAN, B.J., additional, HORSMANHEIMO, A., additional, HORSMANHEIMO, M., additional, SUNY, MICHAEL L. HOWE, additional, HUBER, CHRISTOPH, additional, HURTUBISE, P.E., additional, IKEDA, RICHARD, additional, ITZCHAKI, M., additional, JACOBS, DIANE M., additional, JANICKI, BERNARD W., additional, JARRETT-TOTH, E., additional, JENSEN, PAMELA, additional, JERRY, L. MARTIN, additional, JONES, THOMAS B., additional, JONGENEEL, C. VICTOR, additional, JUNGFER, H., additional, KACENA, AMELIA, additional, KALDANY, A., additional, KAPLAN, ALAN M., additional, KAPLAN, J.G., additional, KASHKET, EVA R., additional, KAY, H. DAVID, additional, KAZURA, J., additional, KEARNEY, J.K., additional, KERMANI-ARAB, V., additional, KIERSZENBAUM, F., additional, KEYSSNER, K., additional, KIRCHNER, H., additional, KIRKPATRICK, CHARLES H., additional, KLEIN, J., additional, KLIMPEL, GARY, additional, KOLB, W.P., additional, KORN, J., additional, KOSKI, L.J., additional, KRAKAUER, R., additional, KRUISBEEK, ADA M., additional, KRUITHOF, E.K.O., additional, KUBO, RALPH T., additional, LANOTTE, M., additional, LAUGHTER, ARLINE H., additional, LAUGHTER, BARBARA J., additional, LA VIA, D.S., additional, LA VIA, M.F., additional, LAWRENCE, E.C., additional, LAWTON, A.R., additional, LEGRAND, L., additional, LEON, MYRON A., additional, LESLIE, G.A., additional, UCLA, JOSHUA LEVY, additional, LICHTMAN, M.A., additional, LIFTON, J., additional, LIGHTBODY, JAMES J., additional, LINKER-ISRAELI, M., additional, LOPATIN, DENNIS E., additional, LORARCHER, ALOIS, additional, LORD, EDITH M., additional, LUCAS, DAVID O., additional, LUCAS, KEES, additional, LUNDIN, A.P., additional, LYDYARD, P.M., additional, MCCALMON, ROBERT T., additional, MACDERMOTT, RICHARD P., additional, MCDOUGAL, J.S., additional, MCINTIRE, K.R., additional, MACKLER, BRUCE F., additional, MADYASTHA, K.R., additional, MADYASTHA, P.R., additional, MÄHLER, BERND, additional, MAKI, TAKASHI, additional, MANNINEN, KIMMO, additional, MARTIJNSE, JOKE, additional, MAWAS, C., additional, MAYER, EUGENE P., additional, MEADE, B., additional, MENDELSOHN, JOHN, additional, MENZEL, J., additional, MERGENHAGEN, S.E., additional, METZGER, JOACHIM, additional, MILLER, GINGER W., additional, MILLER, HAROLD C., additional, MILLER, J., additional, MILLS, G., additional, MINGARI, M.C., additional, MOERMAN, C., additional, MOLDOW, C.F., additional, MONAHAN, T.M., additional, MORETTA, A., additional, MORETTA, L., additional, MORRISON, DAVID C., additional, MOTICKA, EDWARD J., additional, MUCHMORE, ANDREW V., additional, MULLER-EBERHARD, H.J., additional, MUNK, K., additional, MUUL, L., additional, NASH, GEOFFREY S., additional, NEGENDANK, W., additional, NELSON, DAVID L., additional, NELSON, J.A., additional, NETA, R., additional, NEWELL, LAURIE, additional, NG, A.K., additional, O'BRIEN, RICHARD L., additional, OEHLER, J.R., additional, O'NEILL, PEGGY A., additional, OPPENHEIM, JOOST J., additional, ORTALDO, J.R., additional, PAHWA, S., additional, PANIJEL, J., additional, PAPE, GERD R., additional, PARADYSZ, J., additional, PARKER, C.W., additional, PARKER, JOHN W., additional, PARRILLO, JOSEPH E., additional, PAWELEC, G.P., additional, PEARSON, CARL M., additional, PERLMANN, PETER, additional, PILARSKI, LINDA M., additional, PLATA, FERNANDO, additional, PLESCIA, ANNE M., additional, PLESCIA, OTTO J., additional, PONZIO, N.M., additional, POPLACK, D.G., additional, PRATT, KAREN R., additional, PUNTIS, M.C.A, additional, RANNEY, DAVID F., additional, RASMUSSEN, HOWARD, additional, REDELMAN, DOUG, additional, RESCH, KLAUS, additional, RICH, ROBERT R., additional, RICH, SUSAN SOLLIDAY, additional, ROBERTS, R.L., additional, RODE, HAROLD N., additional, ROSENSTREICH, DAVID L., additional, ROSENTHAL, ALAN S., additional, ROSSIO, JEFFREY L., additional, ROWDEN, GEOFFREY, additional, ROWLAND, GEORGE, additional, RUBIN, ARNOLD S., additional, RüDE, ERWIN, additional, RüHL, H., additional, RüHL, U., additional, RYAN, JOHN L., additional, SALVIN, S.B., additional, SASPORTES, M., additional, SCHIRRMACHER, V., additional, SCHMALSTIEG, F.C., additional, SCHMIDTKE, JON R., additional, SCHOLLE, H., additional, SCHRIEBER, A.D., additional, SCHUBERT, RICHARD D., additional, SEGEL, G.B., additional, SELL, STEWART, additional, SHALLER, C., additional, SHARON, N., additional, SHEA, MARY, additional, SHEEHAN, JAMES M., additional, SHEPPARD, HAYNES W., additional, SHEPPARD, J.R., additional, SHERIDAN, JOHN, additional, SHEVACH, ETHAN M., additional, SHIFRINE, M., additional, SHIFTAN, THOMAS A., additional, SHORE, STEVEN L., additional, SIMMONS, RICHARD L., additional, SMITH, ALAN, additional, SMITH, TERRILL K., additional, SOULILLOU, J.P., additional, SPECKART, STEPHEN F., additional, SPELLMAN, CRAIG W., additional, STEGGEMANN, LUDWIG, additional, STEINMAN, L., additional, STEJSKAL, VERA, additional, STEWART, CARLETON C., additional, STITES, DANIEL P., additional, ST. LOUIS, G., additional, STOBO, J.D., additional, STOECK, MICHAEL, additional, STRAUSS, PHYLLIS R., additional, STROBER, W., additional, STROM, TERRY B., additional, SULLIVAN, ARTHUR K., additional, SUNDSMO, J.S., additional, SUTCLIFFE, MARILYN C., additional, SUTHANTHIRAN, M., additional, SWART, A.C.W., additional, TAYLOR, CLIVE R., additional, TEITELBAUM, D., additional, TEODORESCU, MARIUS, additional, TERMIJTELEN, A., additional, THESTRUP-PEDERSEN, KRISTIAN, additional, LE THI, HIEN, additional, THOMAS, DAVID W., additional, THORBECKE, G.J., additional, THORSBY, ERIK, additional, THURMAN, GARY B., additional, TILL, GERD, additional, TILNEY, N.L., additional, TOIVANEN, PAAVO, additional, TOMASI, THOMAS B., additional, TOUTON, M., additional, TRAININ, N., additional, TREFTS, PARK E., additional, TROWBRIDGE, SIDNEYE, additional, TRUFFA-BACHI, PAULO, additional, UBELS-POSTMA, JOSÉ, additional, UMIEL, T., additional, VAN BEKKUM, D.W., additional, VAN DE BERG, TINEKE, additional, VAN DEN TWEEL, JAN G., additional, VAN DEN WESTEN, GERARD, additional, VAN HEES, MARITA, additional, VAN OERS, M.H.J., additional, VAN ROOD, J.J., additional, VOGT, W., additional, WAKSMAN, B.H., additional, WALDMANN, T.A., additional, WALKER, WILLIAM S., additional, WALLON, CH., additional, WARE, CARL F., additional, WEBB, S.R., additional, WEBER, W.T., additional, WEDNER, H.J., additional, WERNET, P., additional, WEST, WILLIAM H., additional, WHISLER, R.L., additional, WIESINGER, DOROTHEE, additional, WIGZELL, HANS, additional, WILCOX, C., additional, WILSON, F.D., additional, WINKELSTEIN, A., additional, WOOD, DAVID D., additional, WOODWARD, JEROLD G., additional, WRIGHT, S.C., additional, YEN, BELINDA, additional, YOSHIDA, TAKESHI, additional, YU, DAVID TAK YAN, additional, ZEIJLEMAKER, W.P., additional, ZICCA, A., additional, ZIER, KAREN, additional, and ZIMMERMANN, RITA, additional

Published
1977
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162. The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind to immunogenic peptides

Author

Buus, Soren, Sette, Alessandro, Colon, Sonia M., Miles, Craig, and Grey, Howard M.

Subjects
Antigen-antibody reactions -- Research -- Analysis, Immunological research -- Analysis -- Research, T cells -- Research -- Analysis, Protein binding -- Research -- Analysis, Peptides -- Research -- Analysis, Science and technology, Analysis, Research
Abstract

The Relation Between Major Histocompatibility Complex (MHC) Restriction and the Capacity of Ia to Bind Immunogenic Peptides IN GENERAL, PROTEIN ANTIGENS ARE PHYSICALLY ALTERED(processed) by accessory cells as a prerequisite [...]

Published
1987

163. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire

Author

Ostrov, David A, Grant, Barry J, Pompeu, Yuri A, Sidney, John, Harndahl, Mikkel, Southwood, Scott, Oseroff, Carla, Lu, Shun, Jakoncic, Jean, de Oliveira, Cesar Augusto F, Yang, Lun, Mei, Hu, Shi, Leming, Shabanowitz, Jeffrey, English, A Michelle, Wriston, Amanda, Lucas, Andrew, Phillips, Elizabeth, Mallal, Simon, Grey, Howard M, Sette, Alessandro, Hunt, Donald F, Buus, Soren, Peters, Bjoern, Ostrov, David A, Grant, Barry J, Pompeu, Yuri A, Sidney, John, Harndahl, Mikkel, Southwood, Scott, Oseroff, Carla, Lu, Shun, Jakoncic, Jean, de Oliveira, Cesar Augusto F, Yang, Lun, Mei, Hu, Shi, Leming, Shabanowitz, Jeffrey, English, A Michelle, Wriston, Amanda, Lucas, Andrew, Phillips, Elizabeth, Mallal, Simon, Grey, Howard M, Sette, Alessandro, Hunt, Donald F, Buus, Soren, and Peters, Bjoern

Abstract

Idiosyncratic adverse drug reactions are unpredictable, dose-independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve immune mechanisms, and genetic association studies have identified strong linkages between drug hypersensitivity reactions to several drugs and specific HLA alleles. One of the strongest such genetic associations found has been for the antiviral drug abacavir, which causes severe adverse reactions exclusively in patients expressing the HLA molecular variant B*57:01. Abacavir adverse reactions were recently shown to be driven by drug-specific activation of cytokine-producing, cytotoxic CD8(+) T cells that required HLA-B*57:01 molecules for their function; however, the mechanism by which abacavir induces this pathologic T-cell response remains unclear. Here we show that abacavir can bind within the F pocket of the peptide-binding groove of HLA-B*57:01, thereby altering its specificity. This provides an explanation for HLA-linked idiosyncratic adverse drug reactions, namely that drugs can alter the repertoire of self-peptides presented to T cells, thus causing the equivalent of an alloreactive T-cell response. Indeed, we identified specific self-peptides that are presented only in the presence of abacavir and that were recognized by T cells of hypersensitive patients. The assays that we have established can be applied to test additional compounds with suspected HLA-linked hypersensitivities in vitro. Where successful, these assays could speed up the discovery and mechanistic understanding of HLA-linked hypersensitivities, and guide the development of safer drugs.

Published
2012

164. Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8 + T cells

Author

Weiskopf, Daniela, primary, Angelo, Michael A., additional, de Azeredo, Elzinandes L., additional, Sidney, John, additional, Greenbaum, Jason A., additional, Fernando, Anira N., additional, Broadwater, Anne, additional, Kolla, Ravi V., additional, De Silva, Aruna D., additional, de Silva, Aravinda M., additional, Mattia, Kimberly A., additional, Doranz, Benjamin J., additional, Grey, Howard M., additional, Shresta, Sujan, additional, Peters, Bjoern, additional, and Sette, Alessandro, additional

Published
2013
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180. Parallel confocal detection of single molecules in real time

Author

Lundquist, Paul M., primary, Zhong, Cheng F., additional, Zhao, Peiqian, additional, Tomaney, Austin B., additional, Peluso, Paul S., additional, Dixon, John, additional, Bettman, Brad, additional, Lacroix, Yves, additional, Kwo, Deborah P., additional, McCullough, Etienne, additional, Maxham, Mark, additional, Hester, Kevin, additional, McNitt, Paul, additional, Grey, Donald M., additional, Henriquez, Carlos, additional, Foquet, Mathieu, additional, Turner, Stephen W., additional, and Zaccarin, Denis, additional

Published
2008
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185. Effects of Age and Long-Term Endurance Training on V̇O2 Kinetics.

Author

GREY, TYLER M., SPENCER, MATTHEW D., BELFRY, GLEN R., KOWALCHUK, JOHN M., PATERSON, DONALD H., and MURIAS, JUAN M.

Subjects
*OXYGEN metabolism, *AGING, *ANALYSIS of variance, *DYNAMICS, *ELECTROCARDIOGRAPHY, *HEART beat, *NEAR infrared spectroscopy, *PHYSICAL fitness, *RESEARCH funding, *STATISTICS, *DATA analysis, *PHYSICAL training & conditioning, *DATA analysis software, *DESCRIPTIVE statistics
Abstract

Purpose: This study examined the effects of age and training status on the pulmonary oxygen uptake (V̇O2p) kinetics of untrained and chronically trained young, middle-age, and older groups of men. Methods: Breath-by-breath V̇O2p and near-infrared spectroscopy-derived muscle deoxygenation ([HHb]) were monitored continuously in young (20-39 yr) trained (YT, n = 8) and untrained (YuT, n = 8), middle-age (40-59 yr) trained (MT, n = 9) and untrained (MuT, n = 9), and older (60-85 yr) trained (OT, n = 9) and untrained (OuT, n = 8) men. On-transient V̇O2p and [HHb] responses to cycling exercise at 80% of the estimated lactate threshold (three repeats) were modeled as monoexponential. Data were scaled to a relative percentage of the response (0%--100%), the signals time aligned, and the individual [HHb]-to-V̇O2p ratio was calculated as the average [HHb]/V̇O2 during the 20- to 120-s period after exercise onset. Results: The time constant for the adjustment of phase II pulmonary V̇O2 (τV̇O2p) was larger in OuT (42.0 ± 11.3 s) compared with that in YT (17.0 ± 7.5 s), MT (18.1 ± 5.3 s), OT (19.8 + 5.4 s), YuT (25.7 + 6.6 s), and MuT (24.4 ± 7.4 s) (P < 0.05). Similarly, the [HHb]/V̇O2 ratio was larger than 1.0 in OuT (1.30 ± 0.13, P < 0.05) and this value was larger than that observed in YT (1.01 ± 0.07), MT (1.04 ± 0.05), OT (1.04 ± 0.04), YuT (1.05 ± 0.03), and MuT (1.02 + 0.09) (P < 0.05). Conclusions: This study showed that the slower V̇O2 kinetics typically observed in older individuals can be prevented by long-term endurance training interventions. Although the role of O2 delivery relative to peripheral use cannot be elucidated from the current measures, the absence of age-related slowing of V̇O2 kinetics seems to be partly related to a preservation of the matching of O2 delivery to O2 utilization in chronically trained older individuals, as suggested by the reduction in the [HHb]/V̇O2 ratio. [ABSTRACT FROM AUTHOR]

Published
2015
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189. Out of balance.

Author

Grey, David M.

Subjects
Mediation -- Usage
Published
2001

200. An Assessment of Patient Satisfaction with Health Care Delivered at Ireland Army Community Hospital.

Author

ACADEMY OF HEALTH SCIENCES (ARMY) FORT SAM HOUSTON TX HEALTH CARE ADMINISTRATI ON, Grey, Carolyn M., ACADEMY OF HEALTH SCIENCES (ARMY) FORT SAM HOUSTON TX HEALTH CARE ADMINISTRATI ON, and Grey, Carolyn M.

Abstract

THIS SURVEY WAS CONDUCTED IN ORDER TO ASCERTAIN THE OVERALL DEGREE OF SATISFACTION OF A POPULATION OF BENEFICIARIES USING HEALTH SERVICES AT IRELAND ARMY COMMUNITY HOSPITAL. DATA WERE COLLECTED USING A SELF-ADMINISTERED, MAILED QUESTIONNAIRE TO A SAMPLE OF 979 PATIENTS, WITH A RESULTANT RESPONSE RATE OF 46.9%. OVERALL SATISFACTION WAS GOOD, WITH A MEAN SCORE OF 2.55 ON A FIVE-POINT SCALE (1=EXCELLENT, 5=POOR). THE CATEGORY OF ACCESS SCORED LOWEST, WITH 'BASE OF MAKING APPOINTMENTS' BEING THE SINGLE LOWEST- SCORING ITEM. RESPONDENTS, IN THEIR FIFTIES, AND THOSE USING CHAMPUS AS THEIR PRIMARY SOURCE OF HEALTH CARE WERE THE LEAST SATISFIED BENEFICIARIES. MOST OFT-CITED AREAS IN NEED OF IMPROVEMENT WERE THE APPOINTMENT SYSTEM, THE EMERGENCY ROOM, AND STAFF COURTESY.

Published
1996

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