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719 results on '"Gress, Thomas M."'

152. DYRK1B regulates Hedgehog-induced microtubule acetylation

Author

Singh, Rajeev, primary, Holz, Philipp Simon, additional, Roth, Katrin, additional, Hupfer, Anna, additional, Meissner, Wolfgang, additional, Müller, Rolf, additional, Buchholz, Malte, additional, Gress, Thomas M., additional, Elsässer, Hans-Peter, additional, Jacob, Ralf, additional, and Lauth, Matthias, additional

Published
2018
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154. Therapeutic targeting of tumor‐associated macrophages in pancreatic neuroendocrine tumors

Author

Krug, Sebastian, primary, Abbassi, Rami, additional, Griesmann, Heidi, additional, Sipos, Bence, additional, Wiese, Dominik, additional, Rexin, Peter, additional, Blank, Annika, additional, Perren, Aurel, additional, Haybaeck, Johannes, additional, Hüttelmaier, Stefan, additional, Rinke, Anja, additional, Gress, Thomas M., additional, and Michl, Patrick, additional

Published
2018
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155. Clinicopathological hallmarks and biomarkers of colorectal neuroendocrine neoplasms

Author

Koenig, Alexander, primary, Krug, Sebastian, additional, Mueller, Daniela, additional, Barth, Peter J., additional, Koenig, Ute, additional, Scharf, Michael, additional, Ellenrieder, Volker, additional, Michl, Patrick, additional, Moll, Roland, additional, Homayunfar, Kia, additional, Kann, Peter Herbert, additional, Stroebel, Philipp, additional, Gress, Thomas M., additional, and Rinke, Anja, additional

Published
2017
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156. Combined microRNA and mRNA microfluidic TaqMan array cards for the diagnosis of malignancy of multiple types of pancreatico-biliary tumors in fine-needle aspiration material

Author

Gress, Thomas M., primary, Lausser, Ludwig, additional, Schirra, Lyn-Rouven, additional, Ortmüller, Lisa, additional, Diels, Ramona, additional, Kong, Bo, additional, Michalski, Christoph W., additional, Hackert, Thilo, additional, Strobel, Oliver, additional, Giese, Nathalia A., additional, Schenk, Miriam, additional, Lawlor, Rita T., additional, Scarpa, Aldo, additional, Kestler, Hans A., additional, and Buchholz, Malte, additional

Published
2017
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159. Functional Imaging in the Follow-Up of Enteropancreatic Neuroendocrine Tumors: Clinical Usefulness and Indications

Author

Merola, Elettra, primary, Pavel, Marianne E., additional, Panzuto, Francesco, additional, Capurso, Gabriele, additional, Cicchese, Noemi, additional, Rinke, Anja, additional, Gress, Thomas M., additional, Iannicelli, Elsa, additional, Prosperi, Daniela, additional, Pizzichini, Patrizia, additional, Prasad, Vikas, additional, Kump, Patrizia, additional, Lipp, Rainer, additional, Partelli, Stefano, additional, Falconi, Massimo, additional, Wiedenmann, Bertram, additional, and Delle Fave, Gianfranco, additional

Published
2017
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162. A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

Author

Heiko, Witt, Miklos Sahin Toth, Olfert, Landt, Jian Min Chen, Thilo, Kahne, Drenth, Joost P. H., Zoltan, Kukor, Edit, Szepessy, Walter, Halangk, Stefan, Dahm, Klaus, Rohde, Hans Ulrich Schulz, Cedric Le Marechal, Nejat, Akar, Ammann, Rudolf W., Kaspar, Truninger, Mario, Bargetzi, Eesh, Bhatia, Carlo, Castellani, Giulia Martina Cavestro, Milos, Cerny, DESTRO-BISOL, Giovanni, Spedini, Gabriella, Hans, Eiberg, Jansen, Jan B. M. J., Monika, Koudova, Eva, Rausova, Milan, Macek, Macek Jr, M., Nuria, Malats, Real, Francisco X., Hans Jurgen Menzel, Pedro, Moral, Roberta, Galavotti, Pier Franco Pignatti, Olga, Rickards, Julius, Spicak, Narcis Octavian Zarnescu, Wolfgang, Bock, Gress, Thomas M., Helmut, Friess, Johann, Ockenga, Hartmut, Schmidt, Roland, Pfutzer, Matthias, Lohr, Peter, Simon, Frank Ulrich Weiss, Lerch, Markus M., Niels, Teich, Volker, Keim, Thomas, Berg, Bertram, Wiedenmann, Werner, Luck, David Alexander Groneberg, Michael, Becker, Thomas, Keil, Andreas, Kage, Jana, Bernardova, Markus, Braun, Claudia, Guldner, Juliane, Halangk, Jonas, Rosendahl, Ulrike, Witt, Matthias, Treiber, Renate, Nickel, Claude, Ferec, Witt, H, SAHIN TOTH, M, Landt, O, Chen, Jm, Kahne, T, Drenth, Jp, Kukor, Z, Szepessy, E, Halangk, W, Dahm, S, Rohde, K, Schulz, Hu, LE MARECHAL, C, Akar, N, Ammann, Rw, Truninger, K, Bargetzi, M, Bhatia, E, Castellani, C, Cavestro, GIULIA MARTINA, Cerny, M, DESTRO BISOL, G, Spedini, G, Eiberg, H, Jansen, Jb, Koudova, M, Rausova, E, MACEK M., Jr, Malats, N, Real, Fx, Menzel, Hj, Moral, P, Galavotti, R, Pignatti, Pf, Rickards, O, Spicak, J, Zarnescu, No, Bock, W, Gress, Tm, Friess, H, Ockenga, J, Schmidt, H, Pfutzer, R, Lohr, M, Simon, P, Weiss, Fu, Lerch, Mm, Teich, N, Keim, V, Berg, T, Wiedenmann, B, Luck, W, Groneberg, Da, Becker, M, Keil, T, Kage, A, Bernardova, J, Braun, M, Guldner, C, Halangk, J, Rosendahl, J, Witt, U, Treiber, M, Nickel, R, and Ferec, C.

Subjects
trypsin inhibitor, Models, Molecular, Enteropeptidase, Pancreatic disease, Membrane transport and intracellular motility [NCMLS 5], arginine, genetic risk, chemistry.chemical_compound, Models, proteinosis, Trypsin, Pancreatic Secretory Trypsin Inhibitor, PRSS1 gene, enteropeptidase, medicine.diagnostic_test, adult, Hydrolysis, cationic trypsinogen, protection, unclassified drug, enzyme activity, female, priority journal, risk factor, CHRONIC PANCREATITIS, protein degradation, Trypsinogen, medicine.drug, medicine.medical_specialty, anionic trypsinogen, Proteolysis, Biology, Article, male, Internal medicine, Genetics, medicine, Matrix-Assisted Laser Desorption-Ionization, Humans, PRSS2, controlled study, human, Molecular gastro-enterology and hepatology [IGMD 2], gene, DNA Primers, Genetic polymorphism, catalysis, Base Sequence, Spectrometry, disease predisposition, Molecular, cationic trypsinogen prss1, glycine, pancreatic secretory trypsin inhibitor spink1, trypsin, trypsinogen, article, chronic pancreatitis, codon, genetic susceptibility, major clinical study, nucleotide sequence, Chronic Disease, Haplotypes, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Mass, medicine.disease, Tripsinogen, Tripsina, Settore BIO/18 - Genetica, Endocrinology, Genetic defects of metabolism [UMCN 5.1], Pancreatitis, chemistry, Genètica
Abstract

Chronic pancreatitis is a common inflammatory disease of the pancreas. Mutations in the genes encoding cationic trypsinogen (PRSS1) and the pancreatic secretory trypsin inhibitor (SPINK1) are associated with chronic pancreatitis. Because increased proteolytic activity owing to mutated PRSS1 enhances the risk for chronic pancreatitis, mutations in the gene encoding anionic trypsinogen (PRSS2) may also predispose to disease. Here we analyzed PRSS2 in individuals with chronic pancreatitis and controls and found, to our surprise, that a variant of codon 191 (G191R) is overrepresented in control subjects: G191R was present in 220/6,459 (3.4%) controls but in only 32/2,466 (1.3%) affected individuals (odds ratio 0.37; P = 1.1 x 10(-8)). Upon activation by enterokinase or trypsin, purified recombinant G191R protein showed a complete loss of trypsin activity owing to the introduction of a new tryptic cleavage site that renders the enzyme hypersensitive to autocatalytic proteolysis. In conclusion, the G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis. The initial experiments were supported by the DFG (Wi 2036/1-1). This work was supported by the Sonnenfeld-Stiftung, Berlin, Germany (to H.W.), the US National Institutes of Health (NIH) (grant DK058088 to M.S.-T.), INSERM (Institut National de la Santé et de la Recherche Médicale) and the Programme Hospitalier de Recherche Clinique (grant PHRC R 08-04 to C.F.)

Published
2006
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163. High Prevalence of Pathological Hydrogen Breath Tests in Patients with Functional Dyspepsia.

Author

Petzold, Golo, Amanzada, Ahmad, Gress, Thomas M., Ellenrieder, Volker, Neesse, Albrecht, and Kunsch, Steffen

Subjects
BREATH tests, LACTOSE intolerance, CROHN'S disease, INDIGESTION
Abstract

Background/Aims: The aim of the study is to investigate the frequency of pathological hydrogen breath tests (HBT) in patients with clinical features of functional dyspepsia (FD) meeting the Rome criteria and normal testing of upper endoscopy and abdominal sonography. Methods: We retrospectively included patients who underwent HBT (lactose, fructose, or glucose) between 2006 and 2012 and who had symptoms of FD. Patients were divided into 2 groups according to medical history and diagnostic results: (I) patients with suspected FD according to the Rome III criteria and (II) patients with an alternative diagnosis such as gastroesophageal reflux disease (GERD) or Crohn's disease (CD). Results: A total of 207/404 patients were assigned to the FD group and 44.4% of these had at least 1 positive HBT and thus more frequently than patients with GERD (20.7%; n = 111; p < 0.001) and with CD (31.7%; n = 63; p = 0.07). Lactose and fructose HBT, but not glucose HBT, occurred significantly more frequently with pathological results than in patients with GERD (p = 0.02; p = 0.002). The probability of a positive HBT increased significantly with increasing number of performed HBT (p < 0.001). Conclusion: We suggest that HBT should be considered in the clinical management of patients with suspected FD. In cases of positive HBTs, a potential causal therapy can be initiated. [ABSTRACT FROM AUTHOR]

Published
2019
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164. Open Surgical versus Minimal Invasive Necrosectomy of the Pancreas—A Retrospective Multicenter Analysis of the German Pancreatitis Study Group

Author

Rasch, Sebastian, primary, Phillip, Veit, additional, Reichel, Stephanie, additional, Rau, Bettina, additional, Zapf, Christian, additional, Rosendahl, Jonas, additional, Halm, Ulrich, additional, Zachäus, Markus, additional, Müller, Martin, additional, Kleger, Alexander, additional, Neesse, Albrecht, additional, Hampe, Jochen, additional, Ellrichmann, Mark, additional, Rückert, Felix, additional, Strauß, Peter, additional, Arlt, Alexander, additional, Ellenrieder, Volker, additional, Gress, Thomas M., additional, Hartwig, Werner, additional, Klar, Ernst, additional, Mössner, Joachim, additional, Post, Stefan, additional, Schmid, Roland M., additional, Seufferlein, Thomas, additional, Siech, Marco, additional, Werner, Jens, additional, Will, Uwe, additional, and Algül, Hana, additional

Published
2016
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167. Sa1389 Clinical Usefulness of Functional Imaging Tests in the Follow-Up of Digestive Neuroendocrine Neoplasms

Author

Merola, Elettra, primary, Pavel, Marianne, additional, Panzuto, Francesco, additional, Capurso, Gabriele, additional, Cicchese, Noemi, additional, Rinke, Anja, additional, Gress, Thomas M., additional, Iannicelli, Elsa, additional, Prosperi, Daniela, additional, Pizzichini, Patrizia, additional, Kump, Patrizia, additional, Lipp, Rainer, additional, Partelli, Stefano, additional, Falconi, Massimo, additional, Wiedenmann, Bertram H., additional, and Fave, Gianfranco Delle, additional

Published
2016
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171. GSK-3β Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic Cancer Progression

Author

Baumgart, Sandra, primary, Chen, Nai-Ming, additional, Zhang, Jin-San, additional, Billadeau, Daniel D., additional, Gaisina, Irina N., additional, Kozikowski, Alan P., additional, Singh, Shiv K., additional, Fink, Daniel, additional, Ströbel, Philipp, additional, Klindt, Caroline, additional, Zhang, Lizhi, additional, Bamlet, William R., additional, Koenig, Alexander, additional, Hessmann, Elisabeth, additional, Gress, Thomas M., additional, Ellenrieder, Volker, additional, and Neesse, Albrecht, additional

Published
2016
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172. DocOx (AIO-PK0106): a phase II trial of docetaxel and oxaliplatin as a second line systemic therapy in patients with advanced pancreatic ductal adenocarcinoma

Author

Ettrich, Thomas J., primary, Perkhofer, Lukas, additional, von Wichert, Goetz, additional, Gress, Thomas M., additional, Michl, Patrick, additional, Hebart, Holger F., additional, Büchner-Steudel, Petra, additional, Geissler, Michael, additional, Muche, Rainer, additional, Danner, Bettina, additional, Kächele, Volker, additional, Berger, Andreas W., additional, Güthle, Melanie, additional, and Seufferlein, Thomas, additional

Published
2016
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174. PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways

Author

Kaistha, Brajesh P., primary, Lorenz, Holger, additional, Schmidt, Harald, additional, Sipos, Bence, additional, Pawlak, Michael, additional, Gierke, Berthold, additional, Kreider, Ramona, additional, Lankat-Buttgereit, Brigitte, additional, Sauer, Melanie, additional, Fiedler, Lisa, additional, Krattenmacher, Anja, additional, Geisel, Bettina, additional, Kraus, Johann M., additional, Frese, Kristopher K., additional, Kelkenberg, Sabine, additional, Giese, Nathalia A., additional, Kestler, Hans A., additional, Gress, Thomas M., additional, and Buchholz, Malte, additional

Published
2016
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175. Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma

Author

Neesse, Albrecht, Krug,Sebastian, Gress,Thomas M., Tuveson,David A., and Michl,Patrick

Subjects
OncoTargets and Therapy
Abstract

Albrecht Neesse,1 Sebastian Krug,1 Thomas M Gress,1 David A Tuveson,2 Patrick Michl11Department of Gastroenterology, Endocrinology, Infectiology and Metabolism, Philipps University Marburg, Marburg, Germany; 2Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USAAbstract: Pancreatic ductal adenocarcinoma is a stroma-rich and highly challenging cancer to treat. Over recent years, it has become increasingly evident that the complex network of soluble cytokines, growth factors, proteases, and components of the extracellular matrix collaboratively interact within the tumor microenvironment, sustaining and driving cancer cell proliferation, invasion, and early metastasis. More recently, the tumor microenvironment has also been appreciated to mediate therapeutic resistance in pancreatic ductal adenocarcinoma, thus opening numerous avenues for novel therapeutic explorations. Inert and soluble components of the tumor stroma have been targeted in order to break down the extracellular matrix scaffold, relieve vessel compression, and increase drug delivery to hypovascular tumors. Moreover, targeting of antiapoptotic, immunosuppressive, and pro-proliferative effects of the tumor stroma provides novel vantage points of attack. This review focuses on current and future developments in pancreatic cancer medicine, with a particular emphasis on biophysical and biochemical approaches that target the tumor microenvironment.Keywords: pancreatic cancer, chemoresistance, tumor stroma, drug delivery

Published
2013

176. Smoking and bone mineral density: comprehensive analyses of the third National Health and Nutrition Examination Survey (NHANES III).

Author

Strozyk, Dominik, Gress, Thomas M., and Breitling, Lutz P.

Abstract

Summary Some questions remain on the relationship between smoking and bone health. Detailed analyses of the relationship between smoking and BMD are presented, essentially ruling out non-linear associations as an explanation for inconsistent results in the literature. Introduction To provide comprehensive multiple regression and dose-response analyses of the association between smoking behavior variables and bone health as assessed by radiologically determined bone mineral density in NHANES III. Methods Analyzes of a representative cross-sectional survey of the noninstitutionalized population of the USA. Self-reported smoking behavior and bone mineral density of 14,510 participants were analyzed using survey design-based multiple linear regression modeling. Dose-response patterns were analyzed using restricted cubic spline regression. Results Femoral neck bone mineral density in current smokers was numerically lower than in never smokers, but this was not statistically significant after controlling for confounders. In former smokers, bone mineral density T scores were 0.064 units higher for every 10 years of abstinence, with little impact of confounder adjustment. Spline regression revealed no relevant nonlinearity in the associations studied. Conclusions Non-linearity is an unlikely explanation for inconsistent results in the literature on smoking and bone mineral density. Further and especially longitudinal studies of the complex relationship smoking with bone health would be particularly important given the still substantial prevalence of smoking in an aging global population. [ABSTRACT FROM AUTHOR]

Published
2018
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177. Glutamate Receptor GRIA3—Target of CUX1 and Mediator of Tumor Progression in Pancreatic Cancer12

Author

Ripka, Stefanie, Riedel, Jan, Neesse, Albrecht, Griesmann, Heidi, Buchholz, Malte, Ellenrieder, Volker, Moeller, Franz, Barth, Peter, Gress, Thomas M, and Michl, Patrick

Subjects
Homeodomain Proteins, Cell Survival, Gene Expression Profiling, Transplantation, Heterologous, Mice, Nude, Nuclear Proteins, Oncogenes, Adenocarcinoma, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, Repressor Proteins, Mice, Cell Movement, Disease Progression, Tumor Cells, Cultured, Animals, Humans, Female, Neoplasm Invasiveness, RNA Interference, Receptors, AMPA, Research Article, Oligonucleotide Array Sequence Analysis, Transcription Factors
Abstract

Previously, we identified the transcription factor CUX1 as an important modulator of invasion and resistance to apoptosis. Expression profiles suggested that CUX1 regulates a complex transcriptional program mediating tumor progression. We aimed to identify functionally relevant targets of CUX1 by using RNA interference (RNAi)-based loss-of-function screens. Therefore, we generated an RNAi library containing putative transcriptional targets of CUX1 identified by microarrays and performed cell viability screens. Using this approach, several CUX1 targets with effect on tumor cell viability were identified, including the glutamate receptor GRIA3, which was validated in detail for its effects on proliferation, apoptosis, and cell migration using RNAi knock-down and overexpression strategies in vitro, as well as xenograft models in vivo. The expression of GRIA3 was evaluated in human pancreatic cancer tissues. We found that knock-down of GRIA3 significantly reduced proliferation and migration and enhanced apoptosis. In contrast, overexpression of GRIA3 significantly reduced apoptosis and enhanced both proliferation and tumor cell migration. GRIA3 could be confirmed as a downstream effector of CUX1 and was expressed in pancreatic cancer tissues. In vivo, GRIA3 significantly enhanced the growth of subcutaneous xenografts. Inhibitors of glutamate receptors such as GYKI52466 and SYM2206 significantly decreased survival of pancreatic cancer cells, suggesting the presence of glutamate signaling in pancreatic cancer. In conclusion, GRIA3 plays a role as a mediator of tumor progression in pancreatic cancer downstream CUX1. To our knowledge, this is the first report to identify a glutamate receptor as a modulator of tumor progression in a solid cancer outside the brain.

Published
2010

179. DocOx (AIO-PK0106): A phase II trial with docetaxel and oxaliplatin as a second-line systemic therapy for patients with advanced and/or metastatic adenocarcinoma of the pancreas—Final results.

Author

Ettrich, Thomas Jens, primary, Perkhofer, Lukas, additional, Kaechele, Volker, additional, Berger, Andreas W., additional, Guethle, Melanie, additional, Muche, Rainer, additional, von Wichert, Goetz, additional, Gress, Thomas M., additional, Michl, Patrick, additional, Geissler, Michael, additional, Hebart, Holger Frithjof, additional, Buechner-Steudel, Petra, additional, and Seufferlein, Thomas, additional

Published
2015
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186. CUX1: a modulator of tumour aggressiveness in pancreatic neuroendocrine neoplasms

Author

Krug, Sebastian, primary, Kühnemuth, Benjamin, additional, Griesmann, Heidi, additional, Neesse, Albrecht, additional, Mühlberg, Leonie, additional, Boch, Michael, additional, Kortenhaus, Juliane, additional, Fendrich, Volker, additional, Wiese, Dominik, additional, Sipos, Bence, additional, Friemel, Juliane, additional, Gress, Thomas M, additional, and Michl, Patrick, additional

Published
2014
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191. Inflammation-Induced NFATc1–STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by KrasG12D

Author

Baumgart, Sandra, primary, Chen, Nai-Ming, additional, Siveke, Jens T., additional, König, Alexander, additional, Zhang, Jin-San, additional, Singh, Shiv K., additional, Wolf, Elmar, additional, Bartkuhn, Marek, additional, Esposito, Irene, additional, Heßmann, Elisabeth, additional, Reinecke, Johanna, additional, Nikorowitsch, Julius, additional, Brunner, Marius, additional, Singh, Garima, additional, Fernandez-Zapico, Martin E., additional, Smyrk, Thomas, additional, Bamlet, William R., additional, Eilers, Martin, additional, Neesse, Albrecht, additional, Gress, Thomas M., additional, Billadeau, Daniel D., additional, Tuveson, David, additional, Urrutia, Raul, additional, and Ellenrieder, Volker, additional

Published
2014
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194. Emerging concepts in pancreatic cancer medicine: targeting the tumor stroma

Author

Neesse,Albrecht, Krug,Sebastian, Gress,Thomas M., Tuveson,David A., Michl,Patrick, Neesse,Albrecht, Krug,Sebastian, Gress,Thomas M., Tuveson,David A., and Michl,Patrick

Abstract

Albrecht Neesse,1 Sebastian Krug,1 Thomas M Gress,1 David A Tuveson,2 Patrick Michl11Department of Gastroenterology, Endocrinology, Infectiology and Metabolism, Philipps University Marburg, Marburg, Germany; 2Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USAAbstract: Pancreatic ductal adenocarcinoma is a stroma-rich and highly challenging cancer to treat. Over recent years, it has become increasingly evident that the complex network of soluble cytokines, growth factors, proteases, and components of the extracellular matrix collaboratively interact within the tumor microenvironment, sustaining and driving cancer cell proliferation, invasion, and early metastasis. More recently, the tumor microenvironment has also been appreciated to mediate therapeutic resistance in pancreatic ductal adenocarcinoma, thus opening numerous avenues for novel therapeutic explorations. Inert and soluble components of the tumor stroma have been targeted in order to break down the extracellular matrix scaffold, relieve vessel compression, and increase drug delivery to hypovascular tumors. Moreover, targeting of antiapoptotic, immunosuppressive, and pro-proliferative effects of the tumor stroma provides novel vantage points of attack. This review focuses on current and future developments in pancreatic cancer medicine, with a particular emphasis on biophysical and biochemical approaches that target the tumor microenvironment.Keywords: pancreatic cancer, chemoresistance, tumor stroma, drug delivery

Published
2013

195. TimeLapseAnalyzer: Multi-target analysis for live-cell imaging and time-lapse microscopy

Author

Huth, Johannes, Buchholz, Malte, Kraus, Johann M., Mølhave, Kristian, Gradinaru, Cristian, v. Wichert, Götz, Gress, Thomas M., Neumann, Heiko, Kestler, Hans A., Huth, Johannes, Buchholz, Malte, Kraus, Johann M., Mølhave, Kristian, Gradinaru, Cristian, v. Wichert, Götz, Gress, Thomas M., Neumann, Heiko, and Kestler, Hans A.

Abstract

The direct observation of cells over time using time-lapse microscopy can provide deep insights into many important biological processes. Reliable analyses of motility, proliferation, invasive potential or mortality of cells are essential to many studies involving live cell imaging and can aid in biomarker discovery and diagnostic decisions. Given the vast amount of image- and time-series data produced by modern microscopes, automated analysis is a key feature to capitalize the potential of time-lapse imaging devices. To provide fast and reproducible analyses of multiple aspects of cell behaviour, we developed TimeLapseAnalyzer. Apart from general purpose image enhancements and segmentation procedures, this extensible, self-contained, modular cross-platform package provides dedicated modalities for fast and reliable analysis of multi-target cell tracking, scratch wound healing analysis, cell counting and tube formation analysis in high throughput screening of live-cell experiments. TimeLapseAnalyzer is freely available (MATLAB, Open Source) at http://www.informatik.uniulm. de/ni/mitarbeiter/HKestler/tla.

Published
2011

197. Epigenetic Regulation of Autophagy by the Methyltransferase G9a

Author

Artal-Martinez de Narvajas, Amaia, primary, Gomez, Timothy S., additional, Zhang, Jin-San, additional, Mann, Alexander O., additional, Taoda, Yoshiyuki, additional, Gorman, Jacquelyn A., additional, Herreros-Villanueva, Marta, additional, Gress, Thomas M., additional, Ellenrieder, Volker, additional, Bujanda, Luis, additional, Kim, Do-Hyung, additional, Kozikowski, Alan P., additional, Koenig, Alexander, additional, and Billadeau, Daniel D., additional

Published
2013
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198. DOCOX: A phase II trial with docetaxel and oxaliplatin as a second-line systemic therapy for patients with advanced and/or metastatic adenocarcinoma of the pancreas.

Author

Ettrich, Thomas Jens, primary, von Wichert, Goetz, additional, Gress, Thomas M., additional, Michl, Patrick, additional, Geissler, Michael, additional, Hebart, Holger Frithjof, additional, Berger, Andreas W., additional, Porzner, Marc, additional, Danner, Bettina, additional, Muche, Rainer, additional, and Seufferlein, Thomas, additional

Published
2013
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