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689 results on '"Goto, Tomoko"'

154. Weekly administration of bevacizumab, eribulin, and oxalilplatin in patients with platinum-resistant and refractory ovarian carcinomas: A phase II study.

Author

Ikeda, Yuji, primary, Takano, Masashi, additional, Kouta, Hiroko, additional, Sasaki, Naoki, additional, Ikeda, Sayaka, additional, Kudoh, Kazuya, additional, Kita, Tsunekazu, additional, Kikuchi, Ryoko, additional, Goto, Tomoko, additional, Furuya, Kenichi, additional, and Kikuchi, Yoshihiro, additional

Published
2014
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156. Combination chemotherapy with temsirolimus and trabectedin for recurrent clear cell carcinoma of the ovary: A phase II single arm clinical trial.

Author

Takano, Masashi, primary, Kouta, Hiroko, additional, Ikeda, Yuji, additional, Sasaki, Naoki, additional, Kudoh, Kazuya, additional, Ikeda, Sayaka, additional, Kita, Tsunekazu, additional, Kikuchi, Ryoko, additional, Goto, Tomoko, additional, Furuya, Kenichi, additional, and Kikuchi, Yoshihiro, additional

Published
2014
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157. This title is unavailable for guests, please login to see more information.

Author

KAMEDA, Takayuki, KATAYAMA, Yuki, GOTO, Tomoko, TORIBA, Akira, TANG, Ning, HAYAKAWA, Kazuichi, 50398426, KAMEDA, Takayuki, KATAYAMA, Yuki, GOTO, Tomoko, TORIBA, Akira, TANG, Ning, HAYAKAWA, Kazuichi, and 50398426

Abstract

A simple and sensitive method for measuring quinoid polycyclic aromatic hydrocarbons (PAHQs) in soluble organic fraction (SOF) of airborne particles based on two-dimensional high-performance liquid chromatography (HPLC) with fluorescence detection was established. The system involves a reversed phase column with naphtylethyl groups bonded silica packing material for sample clean-up, a 6-port switching valve, an ODS column for trapping the fraction containing PAHQs, a reversed phase column with cholesteryl groups bonded silica packing material for sample separation, and a Pt-Rh catalytic column for the reduction of PAHQs to a corresponding fluorescent compound. The accuracy of the assay, as applied to airborne particulate sample extracts spiked with known amounts of PAHQs were 91 – 107%. The detection limits were 19 to 2000 fmol per injection (signal-to-noise ratio = 3), and the calibration range was from 1 to 100 pmol with excellent proportionality (R²≥0.9992) for four kinds of PAHQs: benz[a]anthracene-7, 12-dione, fluoranthene-2, 3-dione, pyrene-1, 6-dione, and pyrene-1, 8-dione. PAHQs in SOF of airborne particles collected in Kyoto, Japan were successfully measured using the established analytical method with simple sample-preparation steps: ultrasonic extraction in organic solvent and concentration under reduced pressure and/or a nitrogen stream.

Published
2013

183. Identification of potential serum markers for endometrial cancer using protein expression profiling

Author

Takano, Masashi, primary, Kikuchi, Yoshihiro, additional, Asakawa, Takayoshi, additional, Goto, Tomoko, additional, Kita, Tsunekazu, additional, Kudoh, Kazuya, additional, Kigawa, Junzo, additional, Sakuragi, Noriaki, additional, Sakamoto, Masaru, additional, Sugiyama, Toru, additional, Yaegashi, Nobuo, additional, Tsuda, Hiroshi, additional, Seto, Hiroshi, additional, and Shiwa, Mieko, additional

Published
2009
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185. Clinical Significance of UDP-Glucuronosyltransferase 1A1*6 for Toxicities of Combination Chemotherapy with Irinotecan and Cisplatin in Gynecologic Cancers

Author

Takano, Masashi, primary, Kato, Masafumi, additional, Yoshikawa, Tomoyuki, additional, Sasaki, Naoki, additional, Hirata, Junko, additional, Furuya, Kenichi, additional, Takahashi, Michiko, additional, Yokota, Harushige, additional, Kino, Nao, additional, Horie, Koji, additional, Goto, Tomoko, additional, Fujiwara, Keiichi, additional, Ishii, Kenji, additional, Kikuchi, Yoshihiro, additional, and Kita, Tsunekazu, additional

Published
2009
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191. ANKH Polymorphisms and Clicking of the Temporomandibular Joint in Dental Residents.

Author

Huang, Boyen, Takahashi, Katsu, Goto, Tomoko, Kiso, Honoka, Sugai, Manabu, Shimizu, Akira, Kosugi, Shinji, and Bessho, Kazuhisa

Abstract

Aim: This study aimed to carry out a case-control research study to assess occurrence of clicking of the temporomandibular joint (TMJ) in order to establish the relationship between TMJ clicking and the genotype of 'ANKH inorganic pyrophosphate transport regulator' (ANKH) polymorphisms. Materials and Method: A sample of 41 first-year dental residents was selected. Each was examined using standard clinical procedures and genotyping techniques. Results: The participation rate was 91.8 %. The prevalence of TMJ clicking was 51.2 % (95 % CI: 35.7-66.7 %). Occurrence of TMJ clicking was not related to age, gender and genotypes of ANKH-OR as well as ANKH-TR polymorphisms ( p ≥ 0.165). Conclusion: A similar distribution of ANKH genotypes in TMJ clicking and asymptomatic individuals has been demonstrated by this study. A high percentage of TMJ clicking has been confirmed. Future investigations are indicated. [ABSTRACT FROM AUTHOR]

Published
2015
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192. Application of anti-BMP antibodies to immunohistochemical examination of fibrous dysplasia.

Author

Kiso, Honoka, Takahashi, Katsu, Kang, Yangsun, Saito, Kazuyuki, Togo, Yumiko, Sakata-Goto, Tomoko, Huang, Boyen, Tsukamoto, Hiroko, Nakashima, Yasuaki, and Bessho, Kazuhisa

Abstract

Objective Fibrous dysplasia of bone (FD) is a benign developmental disorder of bone in which normal bone is replaced by fibrous tissue, containing trabeculae of immature woven bone. This disease has been classified into three types: monostotic (MFD), polyostotic (PFD), and McCune–Albright syndrome (MAS). Occurring in multiple adjacent craniofacial bones (craniofacial FD) is considered to be an MFD lesion. Surgical reduction is performed for form revision after having observed the progress until adulthood, but postoperative recurrence cases are not rare, there is a report of malignant progression to osteosarcoma, and the clinical phenotypes are generally various. This study aimed to identify the relationship between clinical futures of FD and expression of bone morphogenetic protein (BMP) subtypes. Methods We studied 10 cases (9 MFD cases and 1 McCune–Albright syndrome case) diagnosed with fibrous dysplasia in our hospital, and immunohistochemical examinations of the excised sample from each case with anti-BMP-2, 4, 6, and 7 antibodies were performed. Results 5 MFD cases and 1 MAS case underwent reoperation, and the case that had the most number of operations was 9 times in the MFD case. Malignant transformations were not identified. BMP-4, 6, and 7 expressions were positive in all cases, but the expression of BMP-2 was positive only in 6 MFD cases. BMP-2 negative cases tended to undergo reoperation. Conclusions The variable expression of BMP-2 demonstrated in the current study was suggested to be a useful indication for clinical activity and convalescence of the lesions. [ABSTRACT FROM AUTHOR]

Published
2015
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