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1,171 results on '"Gorbach, Sherwood"'

153. Fidaxomicin versus vancomycin for Clostridium difficile infection: meta-analysis of pivotal randomized controlled trials.

Author

Crook, Derrick W, Walker, A Sarah, Kean, Yin, Weiss, Karl, Cornely, Oliver A, Miller, Mark A, Esposito, Roberto, Louie, Thomas J, Stoesser, Nicole E, Young, Bernadette C, Angus, Brian J, Gorbach, Sherwood L, Peto, Timothy E A, Jacobs, Frédérique, Crook, Derrick W, Walker, A Sarah, Kean, Yin, Weiss, Karl, Cornely, Oliver A, Miller, Mark A, Esposito, Roberto, Louie, Thomas J, Stoesser, Nicole E, Young, Bernadette C, Angus, Brian J, Gorbach, Sherwood L, Peto, Timothy E A, and Jacobs, Frédérique

Abstract

Two recently completed phase 3 trials (003 and 004) showed fidaxomicin to be noninferior to vancomycin for curing Clostridium difficile infection (CDI) and superior for reducing CDI recurrences. In both studies, adults with active CDI were randomized to receive blinded fidaxomicin 200 mg twice daily or vancomycin 125 mg 4 times a day for 10 days. Post hoc exploratory intent-to-treat (ITT) time-to-event analyses were undertaken on the combined study 003 and 004 data, using fixed-effects meta-analysis and Cox regression models. ITT analysis of the combined 003/004 data for 1164 patients showed that fidaxomicin reduced persistent diarrhea, recurrence, or death by 40% (95% confidence interval [CI], 26%-51%; P < .0001) compared with vancomycin through day 40. A 37% (95% CI, 2%-60%; P = .037) reduction in persistent diarrhea or death was evident through day 12 (heterogeneity P = .50 vs 13-40 days), driven by 7 (1.2%) fidaxomicin versus 17 (2.9%) vancomycin deaths at <12 days. Low albumin level, low eosinophil count, and CDI treatment preenrollment were risk factors for persistent diarrhea or death at 12 days, and CDI in the previous 3 months was a risk factor for recurrence (all P < .01). Fidaxomicin has the potential to substantially improve outcomes from CDI., Journal Article, Meta-Analysis, Multicenter Study, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published, Study 003/004 Teams

Published
2012

155. Reply to M.R. Green et al

Author

Cornely, Oliver A., primary, Miller, Mark A., additional, Fantin, Bruno R., additional, Mullane, Kathleen M., additional, Kean, Yin, additional, and Gorbach, Sherwood L., additional

Published
2013
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159. Rethinking Strategies to Select Antibiotic Therapy in Clostridium difficile infection.

Author

Chopra, Teena, Goldstein, Ellie J.C., and Gorbach, Sherwood L.

Subjects
VANCOMYCIN, FIDAXOMICIN, CLOSTRIDIOIDES difficile, DISEASE relapse, MORTALITY, PATIENTS, THERAPEUTICS
Abstract

In recent years, Clostridium difficile infection ( CDI) has become a global public health threat associated with increased morbidity, mortality, and economic burden, all of which are exacerbated with disease recurrence. Current guidelines informing treatment decisions are largely based on definitions of disease severity at diagnosis, with subjective components not well delineated across treatment algorithms and clinical trials. Furthermore, there is little evidence linking severity at onset to outcome. However, reducing the risk of recurrence may offer both a better outcome for the individual and decreased downstream economic impact. The authors present data supporting the opinion that patients deemed at low risk for recurrence should receive vancomycin (or metronidazole when cost is an issue), while those at higher risk of recurrence would benefit from fidaxomicin treatment. Although further prospective studies are needed, choosing treatment with the goal of preventing recurrent CDI may offer a better guide than disease severity. [ABSTRACT FROM AUTHOR]

Published
2016
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161. Fidaxomicin Versus Vancomycin for Clostridium difficile Infection: Meta-analysis of Pivotal Randomized Controlled Trials

Author

Crook, Derrick W., primary, Walker, A. Sarah, additional, Kean, Yin, additional, Weiss, Karl, additional, Cornely, Oliver A., additional, Miller, Mark A., additional, Esposito, Roberto, additional, Louie, Thomas J., additional, Stoesser, Nicole E., additional, Young, Bernadette C., additional, Angus, Brian J., additional, Gorbach, Sherwood L., additional, and Peto, Timothy E. A., additional

Published
2012
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167. Risk of Recurrence and Time to Recurrence Following Treatment of Clostridium difficile Infection: Patient Characteristics and the Differential Effect of Fidaxomicin vs. Vancomycin

Author

Golan, Yoav, primary, Louie, Thomas J., additional, Miller, Mark, additional, Mullane, Kathleen M., additional, Weiss, Karl, additional, Lentnek, Arnold, additional, Robinson, James M., additional, Sears, Pamela S., additional, Shue, Youe-Kong, additional, and Gorbach, Sherwood L., additional

Published
2011
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176. Diagnosis and Management of Complicated Intra-Abdominal Infection in Adults and Children: Guidelines by the Surgical Infection Society and the Infectious Diseases Society of America

Author

Solomkin, Joseph S., primary, Mazuski, John E., additional, Bradley, John S., additional, Rodvold, Keith A., additional, Goldstein, Ellie J.C., additional, Baron, Ellen J., additional, O'Neill, Patrick J., additional, Chow, Anthony W., additional, Dellinger, E. Patchen, additional, Eachempati, Soumitra R., additional, Gorbach, Sherwood, additional, Hilfiker, Mary, additional, May, Addison K., additional, Nathens, Avery B., additional, Sawyer, Robert G., additional, and Bartlett, John G., additional

Published
2010
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183. Low-fat, high-fiber diet and serum estrone sulfate in premenopausal women

Author

Woods, Margo N., Gorbach, Sherwood L, Longcope, Christopher, Goldin, Barry R., Dwyer, Johanna T., and Morrill, LaBrode A.

Subjects
Low-fat diet -- Health aspects, Diet -- Research, Estrogen -- Physiological aspects, High-fiber diet -- Health aspects, Fiber in human nutrition -- Physiological aspects, Food/cooking/nutrition, Health
Abstract

The effect of diet on estrogen (main female hormone) levels was investigated in 17 healthy premenopausal women. For four weeks, the women consumed a typical Western diet, which contained 40 percent of its calories in the form of fat, 400 milligrams of cholesterol per day, 12 grams of fiber per day, and twice as much polysaturated as polyunsaturated fatty acids. Subsequently, they were fed a low-fat, high-fiber diet for eight to ten weeks. This diet contained a quarter of its calories in the form of fat, 200 milligrams of cholesterol per day, 40 grams of fiber per day, and equal amounts of polysaturated and polyunsaturated fatty acids. Sixteen of the women had lower levels of a certain type of estrogen when on the low-fat, high-fiber diet; the average decrease was 36 percent. Thus a low-fat, high-fiber diet can substantially reduce blood estrone sulfate levels.

Published
1989

184. Preparing patients for travel

Author

Cahill, Kevin M., Gorbach, Sherwood L., Mitler, Merrill M., and Salata, Robert A.

Subjects
Care and treatment, Methods, Health aspects, Immunization -- Methods -- Health aspects, Travel -- Health aspects -- Methods, Jet lag -- Care and treatment, Developing countries -- Health aspects -- Methods
Abstract

Preparing patients for travel EXPRESS STOP Travel health guidelines: Millions of Americans will visit developing countries this year, but it is estimated that less than 50% will seek adequate medical [...]

Published
1987

185. The doctors' anti-breast-cancer diet

Author

Gorbach, Sherwood L., Zimmerman, David, and Woods, Margo

Subjects
High-fiber diet, Breast cancer -- Diet therapy, Cancer -- Prevention, Low-fat diet, Estrogen -- Physiological aspects
Published
1984

186. Recommendations for Probiotic Use—2008

Author

Floch, Martin H., primary, Walker, W. Allan, additional, Guandalini, Stefano, additional, Hibberd, Patricia, additional, Gorbach, Sherwood, additional, Surawicz, Christina, additional, Sanders, Mary Ellen, additional, Garcia-Tsao, Guadalupe, additional, Quigley, Eamonn M. M., additional, Isolauri, Erika, additional, Fedorak, Richard N., additional, and Dieleman, Levinus A., additional

Published
2008
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189. New editors

Author

Gorbach, Sherwood L.

Subjects
Communicable diseases -- Care and treatment, Physicians -- Practice, Health, Health care industry
Published
2006

191. Opinion; FOOD SUPPLY; 'Super Bugs' Have Invaded Our Meat

Author

Gorbach, Sherwood L.

Subjects
Antibiotics in animal nutrition -- Environmental aspects, Drug resistance in microorganisms -- Causes of, Antibiotics in agriculture -- Evaluation, Meat -- Contamination, Animal feeding and feeds -- Health aspects, Livestock industry -- Health aspects, General interest, News, opinion and commentary
Published
2001

192. Response to Hatoum and Walton

Author

Shevitz, Abby H, primary, Wilson, Ira B, additional, McDermott, Ann Y, additional, Spiegelman, Donna, additional, Skinner, Sarah C, additional, Antonsson, Kristina, additional, Layne, Jennifer E, additional, Beaston-Blaakman, Aaron, additional, Shepard, Donald S, additional, and Gorbach, Sherwood L, additional

Published
2005
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195. Treating diarrhoea

Author

Gorbach, Sherwood L.

Subjects
Care and treatment, Health aspects, Antidiarrheals -- Health aspects, Diarrhea -- Care and treatment
Abstract

Diarrhoea is a great equaliser. It afflicts all ranks, young and old, hale and infirm, with symptoms that range from mild discomfort to life threatening dehydration. The British Society for [...]

Published
1997

199. Introduction

Author

Barza, Michael, primary, Gorbach, Sherwood, additional, and DeVincent, Stephen J., additional

Published
2002
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