151. Histopathological evidence of protective action of garlic against collagen and arachidonic acid toxicity in rabbits.
- Author
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Alnaqeeb MA, Ali M, Thomson M, Khater SH, Gomes SA, and al-Hassan JM
- Subjects
- Animals, Arachidonic Acid administration & dosage, Collagen administration & dosage, Female, Heart drug effects, Injections, Intravenous, Liver drug effects, Liver pathology, Lung drug effects, Lung pathology, Myocardium pathology, Rabbits, Arachidonic Acid toxicity, Collagen toxicity, Fibrinolytic Agents pharmacology, Garlic, Plants, Medicinal
- Abstract
Soluble rat tail tendon collagen produced respiratory distress, agitation, convulsions and finally death in rabbits when infused intravenously (i.v.) in lethal doses. Similar observations were noted when a lethal dose of arachidonic acid (unsaturated essential fatty acid) was infused. These agents caused thrombocytopenia, indicative of in vivo platelet aggregation, hypotension and increased levels of thromboxane (TX) B2 (a stable metabolite of TXA2) in the plasma. Histopathological examination of lung, heart and liver tissue indicated that the lungs and livers of treated animals were adversely affected, while heart tissues appeared to be normal. Histopathological examination of lung and liver tissues of animals pretreated with garlic, then treated with a lethal dose of collagen or arachidonic acid showed a significant reduction in the damage observed compared to animals not pretreated with garlic.
- Published
- 1992
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