678 results on '"Gmel, G"'
Search Results
152. Measuring alcohol-related consequences in school surveys: alcohol-attributable consequences or consequences with students' alcohol attribution.
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Gmel G, Kuntsche E, Wicki M, and Labhart F
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In alcohol epidemiology surveys, there is a tradition of measuring alcohol-related consequences using respondents' attribution of alcohol as the cause. The authors aimed to compare the prevalence and frequency of self-attributed consequences to consequences without self-attribution using alcohol-attributable fractions (AAF). In 2007, a total of 7,174 Swiss school students aged 13-16 years reported the numbers of 6 alcohol-related adverse consequences (e.g., fights, injuries) they had incurred in the past 12 months. Consequences were measured with and without attribution of alcohol as the cause. The alcohol-use measures were frequency and volume of drinking in the past 12 months and number of risky single-occasion (> or =5 drinks) drinking episodes in the past 30 days. Attributable fractions were derived from logistic (> or =1 incident) and Poisson (number of incidents) regression analyses. Although relative risk estimates were higher when alcohol-attributed consequences were compared with nonattributed consequences, the use of AAFs resulted in more alcohol-related consequences (10,422 self-attributed consequences vs. 24,520 nonattributed consequences determined by means of AAFs). The likelihood of underreporting was higher among drinkers with intermediate frequencies than among either rare drinkers or frequent drinkers. Therefore, the extent of alcohol-related adverse consequences among adolescents may be underestimated when using self-attributed consequences, because of differential attribution processes, especially among infrequent drinkers. [ABSTRACT FROM AUTHOR]
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- 2010
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153. Dimensionality of drinking consequences -- cross-cultural comparability and stability over time.
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Wicki M, Gustafsson N, Mäkelä P, and Gmel G
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- 2009
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154. Who drinks most of the total alcohol in young men--risky single occasion drinking as normative behaviour.
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Gmel G, Gaume J, Faouzi M, Kulling JP, and Daeppen JB
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The objectives of this study were to analyse (a) the distribution of risky single-occasion drinking (RSOD) among 19-year-old men in Switzerland and (b) to show the percentage of all alcohol consumption in the form of RSOD. Methods: The study was based on a census of Swiss francophone 19-year-old men consecutively reporting for processing. The study was conducted at Army Recruitment Center. The participants were 4116 recruits consecutively enrolling for mandatory army recruitment procedures between 23 January and 29 August in 2007. The measures were alcohol consumption measured in drinks of ~10 g of pure alcohol, number of drinking occasions with six or more drinks (RSOD) in the past 12 months and a retrospective 1 week drinking diary. Results: 264 recruits were never seen by the research staff, 3536 of the remaining 3852 conscripts completed a questionnaire which showed that 7.2% abstained from alcohol and 75.5% of those drinking had an RSOD day at least monthly. The typical frequency of drinking was 1-3 days per week on weekends. The average quantity on weekends was about seven drinks, 69.3% of the total weekly consumption was in the form of RSOD days, and of all the alcohol consumed, 96.2% was by drinkers who had RSOD days at least once a month. Conclusion: Among young men, RSOD constitutes the norm. Prevention consequently must address the total population and not only high-risk drinkers. [ABSTRACT FROM AUTHOR]
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- 2008
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155. Do objective measures of blood alcohol concentrations make more sense than self-reports in emergency department studies?
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Gmel G, Kuendig H, Augsburger M, Schreyer N, and Daeppen J
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- 2008
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156. Spreading or concentrating drinking occasions - who is most at risk?
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Kuntsche S, Plant ML, Plant MA, Miller P, and Gmel G
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- 2008
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157. Brief alcohol interventions: do counsellors' and patients' communication characteristics predict change?
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Gaume J, Gmel G, and Daeppen JB
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Aims: To identify communication characteristics of patients and counsellors during brief alcohol intervention (BAT) which predict changes in alcohol consumption 12 months later. Methods: Tape-recordings of 97 BAT sessions with hazardous drinkers were analysed using the Motivational Interviewing Skill Code (MISC). Outcome measures were (i) baseline to a 12-month difference in the weekly drinking quantity, and (ii) baseline to a 12-month difference in heavy drinking episodes per month. Bivariate analyses were conducted for all MISC measures, and significant variables were included in multiple linear regression models. Results: Patient communication characteristics (ability to change) during BAT significantly predicted the weekly drinking quantity in the multiple linear regression model. There were significant differences for some of the counsellor skills in bivariate analyses but not in the multiple regression model adjusting for patients' talk characteristics. Changes in heavy drinking showed no significant association with patient or counsellor skills in the multiple linear regression model. Conclusion: Findings indicate that the more the patient expresses ability to change during the intervention, the more weekly alcohol use decreases. The role of the counsellor during the interaction, and influence on the outcomes was not clearly established. Implications for BAT and related research are discussed. [ABSTRACT FROM AUTHOR]
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- 2008
158. Brief alcohol intervention and alcohol assessment do not influence alcohol use in injured patients treated in the emergency department: a randomized controlled clinical trial [corrected] [published erratum appears in ADDICTION 2007 Dec;102(12):1995].
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Daeppen J, Gaume J, Bady P, Yersin B, Calmes J, Givel JC, and Gmel G
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AIMS: To evaluate the effectiveness of brief alcohol intervention (BAI) in reducing alcohol use among hazardous drinkers treated in the emergency department (ED) after an injury; in addition it tests whether assessment of alcohol use without BAI is sufficient to reduce hazardous drinking. DESIGN: Randomized controlled clinical trial with 12-month follow-up conducted between January 2003 and June 2005. SETTING: Urban academic emergency department (ED) of the Lausanne University Hospital, Lausanne, Switzerland. PARTICIPANTS: A total of 5136 consecutive patients attending ED after an injury completed a seven-item general and a three-item alcohol screen and 1472 (28.7%) were positive for hazardous drinking according to the National Institute on Alcohol Abuse and Addiction definition; of these 987 (67.1%) were randomized into a BAI group (n = 310) or a control group with screening and assessment (n = 342) or a control group with screening only (n = 335) and then a total of 770 patients (78.0%) completed the 12-month follow-up procedures. INTERVENTION: A single 10-15-minute session of standardized BAI conducted by a trained research assistant. MEASUREMENTS: Percentage of participants who have changed to low-risk drinking at follow-up. FINDINGS: Data obtained at 12 months indicated that similar proportions were low-risk drinkers in BAI versus control groups with and without assessment (35.6%, 34.0%, 37.0%, respectively, P = 0.71). Data also indicated similar reductions in drinking frequency, quantity, binge drinking frequency and Alcohol Use Disorders Identification Test (AUDIT) scores across groups. All groups reported similar numbers of days hospitalized and numbers of medical consults in the last 12 months. A model including age groups, gender, AUDIT and injury severity scores indicated that BAI had no influence on the main alcohol use outcome. CONCLUSIONS: This study provides the evidence that a 10-15-minute BAI does not decrease alcohol use and health resource utilization in hazardous drinkers treated in the ED, and demonstrates that commonly found decreases in hazardous alcohol use in control groups cannot be attributed to the baseline alcohol assessment. [ABSTRACT FROM AUTHOR]
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- 2007
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159. Changes in adolescents' reasons for drinking in Switzerland and associations with alcohol use from 1994 to 2002.
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Kuntsche E and Gmel G
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PURPOSE: To determine changes in the prevalence of reasons for drinking and their associations with alcohol use among adolescents in Switzerland from 1994 to 2002. METHOD: Based on national representative samples of 3792 alcohol-using students in 8th and 9th grades in Switzerland (mean age 15.5 years, SD .7), chi-square tests were used to determine changes in reasons for drinking over time. To determine associations between reasons and alcohol use and changes in these associations over time, multiple regression models were estimated separately for the frequency of alcohol consumption and drunkenness. RESULTS: Most adolescents reported drinking to celebrate special occasions, because they wanted to try alcohol, or because they liked the taste of alcoholic drinks. From 1994 to 2002, an increase in all reasons was observed. In multiple regressions, nearly all reasons were significantly related to alcohol consumption and drunkenness. With two exceptions, no interaction with the study year was found. Furthermore, the number of reasons cited by the adolescents surveyed is important: the more reasons they indicated, the more often they drank. The highest alcohol use in 2002 was found among adolescents who indicated all or nearly all reasons, a group that did not exist in 1994. CONCLUSIONS: There appears to be a new group of adolescents who indicated a high number of different reasons for drinking, who often consumed alcohol, and who were frequently drunk. Prevention approaches should be especially targeted at this new risk group. [ABSTRACT FROM AUTHOR]
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- 2006
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160. Alcohol-attributable injuries in admissions to a swiss emergency room--an analysis of the link between volume of drinking, drinking patterns, and preattendance drinking.
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Gmel G, Bissery A, Gammeter R, Givel JC, Calmes JM, Yersin B, and Daeppen JB
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BACKGROUND: An association between alcohol consumption and injury is clearly established from volume of drinking, heavy episodic drinking (HED), and consumption before injury. Little is known, however, about how their interaction raises risk of injury and what combination of factors carries the highest risk. This study explores which of 11 specified groups of drinkers (a) are at high risk and (b) contribute most to alcohol-attributable injuries. METHODS: In all, 8,736 patients, of whom 5,077 were injured, admitted to the surgical ward of the emergency department of Lausanne University Hospital between January 1, 2003, and June 30, 2004, were screened for alcohol use. Eleven groups were constructed on the basis of usual patterns of intake and preattendance drinking. Odds ratios (ORs) comparing injured and noninjured were derived, and alcohol-attributable fractions of injuries were calculated from ORs and prevalence of exposure groups. RESULTS: Risk of injury increased with volume of drinking, HED, and preattendance drinking. For both sexes, the highest risk was associated with low intake, HED, and 4 (women), 5 (men), or more drinks before injury. At the same level of preattendance drinking, high-volume drinkers were at lower risk than low-volume drinkers. In women, the group of low-risk non-HED drinkers taking fewer than 4 drinks suffered 47.5% of the alcohol-attributable injuries in contrast to only 20.4% for men. Low-volume male drinkers with HED had more alcohol-attributable injuries than that of low-volume female drinkers with HED (46.9% vs 23.2%). CONCLUSIONS: Although all groups of drinkers are at increased risk of alcohol-related injury, those who usually drink little but on occasion heavily are at particular risk. The lower risk of chronic heavy drinkers may be due to higher tolerance of alcohol. Prevention should thus target heavy-drinking occasions. Low-volume drinking women without HED and with only little preattendance drinking experienced a high proportion of injuries; such women would be well advised to drink very little or to take other special precautions in risky circumstances. [ABSTRACT FROM AUTHOR]
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- 2006
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161. Measuring alcohol consumption -- should the 'graduated frequency' approach become the norm in survey research?
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Gmel G, Graham K, Kuendig H, and Kuntsche S
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AIMS: To analyse whether recommendations for the graduated frequency (GF) approach to measure alcohol consumption are justified in a multi-cultural comparative study. DESIGN: Representative surveys, conducted between 1995 and 2003, of 10 countries participating in the GENACIS project (Gender, Alcohol and Culture: an International Study). MEASUREMENTS: Usual quantity, usual frequency and mean consumption per day measured with three instruments: GF, generic quantity-frequency (QF) and beverage-specific quantity-frequency (QFBS). FINDINGS: The GF did not consistently yield higher volumes and quantities across all countries compared with the generic QF, while the QFBS resulted in higher quantities and higher volumes compared with the GF (in all but one country) and the QF. Frequencies were mostly higher on the GF compared with the QF and QFBS but there was also evidence of over-reporting of frequencies with the GF. Results for the GF suggested that it was implemented improperly in at least three of the 10 countries. CONCLUSION: The GF does not appear to be appropriate for cross-cultural research. It results in over-reporting of frequencies and appears to be too complex to be administered correctly in many countries. The best measure for these purposes appeared to be the QFBS particularly because it captures more effectively the variability of different alcoholic beverages with different ethanol contents and consumption with different vessel sizes. [ABSTRACT FROM AUTHOR]
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- 2006
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162. Cannabiskonsum in der Schweiz: Pr�valenz und�Determinanten f�r Risikokonsum.
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Neuenschwander, M, Frick, U, Gmel, G, and Rehm, J
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- 2005
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163. Emotional wellbeing and violence among social and solitary risky single occasion drinkers in adolescence.
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Kuntsche EN and Gmel G
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OBJECTIVES: To classify adolescents according to risky single occasion drinking (RSOD) and their level of social integration, and to test whether these groups (social non-RSODs, social RSODs, solitary non-RSODs, solitary RSODs) differ in terms of emotional well-being and violence-related variables. METHOD: K-means cluster and multiple logistic regression analyses were performed based on a cross-sectional national representative sample of 3861 8th and 9th graders in Switzerland (mean age 15.3; SD = 0.88). RESULTS: Although RSODs in general appear to be more violent, social RSODs tend to be more violent than solitary RSODs. Although RSODs reveal a lower life satisfaction generally and tend to have more depressive moods, solitary RSODs are even less satisfied and more depressive. In addition, the latter tend to have lower self-esteem and are more often victims of bullying. CONCLUSIONS: RSODs are not a homogeneous group of adolescents and preventive efforts, such as competence-enhancing and social resistance programmes, should be applied in accordance with the constellation of associated problems: solitary RSODs appear to be socially inhibited, depressive and often victims of bullying, whereas social RSODs appear to be socially accepted but are prone to be violent offenders. [ABSTRACT FROM AUTHOR]
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- 2004
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164. Changes in alcohol consumption following a reduction in the price of spirits: a natural experiment in Switzerland.
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Heeb J, Gmel G, Zurbrügg C, Kuo M, and Rehm J
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AIMS: To discover what changes in alcohol consumption had occurred in subgroups defined by age, sex, volume of drinking and drinking occasions, following a reduction in the price of spirits in Switzerland in July 1999. DESIGN: Quasi-experimental. Longitudinal general-population survey with baseline 3 months before and follow-up 3 months after price change. PARTICIPANTS: Probabilistic telephone sample of 1347 individuals with at least monthly consumption on average in the previous 6 months at both interviews. The response rate at baseline was 74,8% and the attrition rate from baseline to follow-up 20.2%. MEASUREMENTS: Alcohol consumption was assessed by means of a beverage-specific graduated-frequency measure. High volume of drinking was defined as 40 + g/day for men and 20 + g/day for women. Binge drinking was defined as six + drinks on an occasion for men and four + drinks for women. FINDINGS: Spirits consumption increased significantly (by 28.6%) in the total sample, and specifically in young males and in individuals who were low-volume drinkers at baseline. Consumption of alcohol overall, or of wine or beer, did not change significantly. No indication of effects of substitution was found. CONCLUSIONS: Spirits consumption showed price-responsiveness in the early postintervention period. This finding is of particular interest, as (a) the increase in spirits consumption took place at a time of generally declining consumption of alcohol in Switzerland; and (b) in contrast to the findings of most studies, the intervention, namely price reduction, increased availability. [ABSTRACT FROM AUTHOR]
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- 2003
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165. Harmful alcohol use.
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Gmel G and Rehm J
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Alcohol misuse can harm people other than the drinker, and can have negative consequences for society as a whole. It is commonly believed to play a role in decreased worker productivity, increased unintentional injuries, aggression and violence against others, and child and spouse abuse. Research findings support the idea that drinking is involved in or associated with many of these social harms, but do not offer evidence that it causes these effects. Methodological flaws characterize much of the research in this area. Use of better design and statistical methodology is necessary in order to clarify the relationship between drinking and the harmful consequences it is believed to cause. [ABSTRACT FROM AUTHOR]
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- 2003
166. Alcohol-related morbidity and mortality.
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Rehm J, Gmel G, Sempos CT, and Trevisan M
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Alcohol use is related to a wide variety of negative health outcomes including morbidity, mortality, and disability. Research on alcohol-related morbidity and mortality takes into account the varying effects of overall alcohol consumption and drinking patterns. The results from this epidemiological research indicate that alcohol use increases the risk for many chronic health consequences (e.g., diseases) and acute consequences (e.g., traffic crashes), but a certain pattern of regular light-to-moderate drinking may have beneficial effects on coronary heart disease. Several issues are relevant to the methodology of studies of alcohol-related morbidity and mortality, including the measurement of both alcohol consumption and the outcomes studied as well as study design. Broad summary measures that reflect alcohol's possible effects on morbidity, mortality, and disability may be more useful than measures of any one outcome alone. [ABSTRACT FROM AUTHOR]
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- 2003
167. Public health then and now. Can legislation prevent debauchery? Mother gin and public health in 18th-century England.
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Warner J, Her M, Gmel G, and Rehm J
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The 'gin epidemic' of 1720 to 1751 in England was the first time that government intervened in a systematic fashion to regulate and control sales of alcohol. The epidemic therefore provides an opportunity to gauge the effects of multiple legislative interventions over time. Toward that end, we employed time series analysis in conjunction with qualitative methodologies to test the interplay of multiple independent variables, including real wages and taxes, on the consumption of distilled spirits from 1700 through 1771. The results showed that each of the 3 major gin acts was successful in the short term only, consistent with the state's limited resources for enforcement at the local level, and that in each instance consumption actually increased shortly thereafter. This was true even of the Gin Act of 1751, which, contrary to the assumptions of contemporaries and many historians, succeeded by accident rather than by design. The results also suggest that the epidemic followed the inverse U-shaped trajectory of more recent drug scares and that consumption declined only after the more deleterious effects of distilled spirits had been experienced by large numbers of people. [ABSTRACT FROM AUTHOR]
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- 2001
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168. Predictors of smoking status after eight years: the interaction of stages of change and addiction variables.
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Schmid H and Gmel G
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- 1999
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169. Measuring alcohol consumption-is a reasonable change always reasonable? Response to Kiefer & Spanagel (2006)
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Gmel G, Graham K, Kuendig H, and Kuntsche S
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- 2006
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170. Book Review
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Gmel, G. and Kuntsche, E.
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- 2004
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171. [Alcohol-related injuries--an emergency department study in the Lausanne University Hospital]
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Gmel G, Kuendig H, Gaume J, and Jean-Bernard Daeppen
172. Gender and cultural differences in the association between family roles, social stratification, and alcohol use: a European cross-cultural analysis
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Kuntsche S, Gmel G, Ra, Knibbe, Kuendig H, Bloomfield K, Kramer S, and Ulrike Grittner
173. Drinking patterns and their gender differences in Europe
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Mäkelä P, Gmel G, Ulrike Grittner, Kuendig H, Kuntsche S, Bloomfield K, and Room R
174. The world health organization's global monitoring system on alcohol and health
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Poznyak, V., Fleischmann, A., Dag Rekve, Rylett, M., Rehm, J., and Gmel, G.
175. At-risk drinking and drug use among patients seeking care in an emergency department
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Ea, Fleming, Gmel G, Bady P, Yersin B, Jc, Givel, Brown D, and Jean-Bernard Daeppen
176. Alcohol consumption and ethyl carbamate
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Allen, N., Anderson, L. M., Beland, F. A., Bénichou, J., Beral, V., Bloomfield, K., Brooks, P. J., Cai, L., Cho, S. -I, Crabb, D. W., Eriksson, P., Gapstur, S. M., Gmel, G., Griciute, L. -L, Kono, S., Lachenmeier, D. W., La Vecchia, C., M. Matilde Marques, Miller, A. B., Rehm, J., Rehn-Mendoza, N., Rusyn, I., Seitz, H. K., Weiderpass, E., Willett, W. C., Yokoyama, A., Zhang, Z. -F, Huici-Montagud, A., Altieri, A., Baan, R., Balbo, S., Berthiller, J., Bouvard, V., Brennan, P., Cogliano, V. J., El Ghissassi, F., Ferrari, P., Franceschi, S., Gaudin, N., Grosse, Y., Hashibe, M., Islami, F., Lee, Y. -C A., Marron, M., Mitchell, J., Napalkov, N., Secretan, B., Straif, K., Tong, W. -M, Egraz, S., Javin, M., Kajo, B., Lézère, M., Lorenzen-Augros, H., Benbrahim-Tallaa, L., Freeman, C., Guha, N., Galichet, L., Hameau, A. -S, Moutinho, S., and Russell, D.
177. Alcohol consumption and ethyl carbamate
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Allen, N., Anderson, L. M., Frederick Beland, Bénichou, J., Beral, V., Bloomfield, K., Brooks, P. J., Cai, L., Cho, S. -I, Crabb, D. W., Eriksson, P., Gapstur, S. M., Gmel, G., Griciute, L. -L, Kono, S., Lachenmeier, D. W., La Vecchia, C., Marques, M. M., Miller, A. B., Rehm, J., Rehn-Mendoza, N., Rusyn, I., Seitz, H. K., Weiderpass, E., Willett, W. C., Yokoyama, A., Zhang, Z. -F, Huici-Montagud, A., Altieri, A., Baan, R., Balbo, S., Berthiller, J., Bouvard, V., Brennan, P., Cogliano, V. J., El Ghissassi, F., Ferrari, P., Franceschi, S., Gaudin, N., Grosse, Y., Hashibe, M., Islami, F., Lee, Y. -C A., Marron, M., Mitchell, J., Napalkov, N., Secretan, B., Straif, K., Tong, W. -M, Egraz, S., Javin, M., Kajo, B., Lézère, M., Lorenzen-Augros, H., Benbrahim-Tallaa, L., Freeman, C., Guha, N., Galichet, L., Hameau, A. -S, Moutinho, S., and Russell, D.
178. Brief alcohol intervention for hazardous drinkers attending emergency department: A randomized controlled trial
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Daeppen, J. B., Gaume, J., Pierre Bady, Yersin, B., Calmes, J. M., Givel, J. C., and Gmel, G.
179. Within-session changes in therapist and client behaviors during an alcohol brief motivational intervention for young men
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Jacques Gaume, Magill M, Longabaugh R, Bertholet N, Gmel G, and Daeppen J
180. More is not always better-comparison of three instruments measuring volume of drinking in a sample of young men and their association with consequences
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Gmel G, Joseph Studer, Deline S, Baggio S, N'Goran A, Mohler-Kuo M, and Jb, Daeppen
181. Distribution of major health risks: Findings from the global burden of disease study
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Rodgers, A., Ezzati, M., Vander Hoorn, S., Lopez, A.D., Lin, R.-B., Murray, C.J.L., Fishman, S., Caulfield, L.E., de Onis, M., Blössner, M., Hyder, A.A., Mullany, L., Black, R.E., Stoltzfus, R.J., Rice, A.J., West, K.P., Lawes, C., Law, M., Elliott, P., MacMahon, S., James, W.P.T., Jackson-Leach, R., Ni Mhurchu, C., Kalamara, E., Shayeghi, M., Rigby, N.J., Nishida, C., Lock, K., Pomerleau, J., Causer, L., McKee, M., Bull, F.C., Dixon, T., Ham, S., Neiman, A., Pratt, M., Rehm, J., Room, R., Monteiro, M., Gmel, G., Graham, K., Rehn, N., Sempos, C.T., Frick, U., Jernigan, D., Degenhardt, L., Hall, W., Warner-Smith, M., Lynskey, M., Slaymaker, E., Walker, N., Armstrong, T., Collumbien, M., Gerressu, M., Cleland, J., Prüss-Ustun, A., Kay, D., Fewtrell, L., Bartram, J., Cohen, A., Anderson, R., Ostro, B., Dev Pandey, K., Krzyzanowski, M., Künzli, N., Gutschmidt, K., Pope, A., Romieu, I., Samet, J., Smith, K., Smith, K.R., Mehta, S., Feuz, M., Landrigan, P., Ayuso, J.L., McMichael, A., Campbell-Lendrum, D., Kovats, S., Edwards, S., Wilkinson, P., Tanser, F., Le Sueur, D., Schlesinger, M., Andronova, N., Nicholls, R., Wilson, T., Hales, S., Concha, M., Imel Nelson, D., Fingerhut, M., Leigh, J., Corvalan, C., Driscoll, T., Kyle Steenland, N., Punnett, L., Tak, S.W., Phillips, S., Hauri, A.M., Armstrong, G.L., Hutin, Y.J.F., Andrews, G., Corry, J., Issakidis, C., Slade, T., Swanston, H., Blakely, T., Kieft, C., Wilson, N., Woodward, A., Rodgers, A., Ezzati, M., Vander Hoorn, S., Lopez, A.D., Lin, R.-B., Murray, C.J.L., Fishman, S., Caulfield, L.E., de Onis, M., Blössner, M., Hyder, A.A., Mullany, L., Black, R.E., Stoltzfus, R.J., Rice, A.J., West, K.P., Lawes, C., Law, M., Elliott, P., MacMahon, S., James, W.P.T., Jackson-Leach, R., Ni Mhurchu, C., Kalamara, E., Shayeghi, M., Rigby, N.J., Nishida, C., Lock, K., Pomerleau, J., Causer, L., McKee, M., Bull, F.C., Dixon, T., Ham, S., Neiman, A., Pratt, M., Rehm, J., Room, R., Monteiro, M., Gmel, G., Graham, K., Rehn, N., Sempos, C.T., Frick, U., Jernigan, D., Degenhardt, L., Hall, W., Warner-Smith, M., Lynskey, M., Slaymaker, E., Walker, N., Armstrong, T., Collumbien, M., Gerressu, M., Cleland, J., Prüss-Ustun, A., Kay, D., Fewtrell, L., Bartram, J., Cohen, A., Anderson, R., Ostro, B., Dev Pandey, K., Krzyzanowski, M., Künzli, N., Gutschmidt, K., Pope, A., Romieu, I., Samet, J., Smith, K., Smith, K.R., Mehta, S., Feuz, M., Landrigan, P., Ayuso, J.L., McMichael, A., Campbell-Lendrum, D., Kovats, S., Edwards, S., Wilkinson, P., Tanser, F., Le Sueur, D., Schlesinger, M., Andronova, N., Nicholls, R., Wilson, T., Hales, S., Concha, M., Imel Nelson, D., Fingerhut, M., Leigh, J., Corvalan, C., Driscoll, T., Kyle Steenland, N., Punnett, L., Tak, S.W., Phillips, S., Hauri, A.M., Armstrong, G.L., Hutin, Y.J.F., Andrews, G., Corry, J., Issakidis, C., Slade, T., Swanston, H., Blakely, T., Kieft, C., Wilson, N., and Woodward, A.
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Most analyses of risks to health focus on the total burden of their aggregate effects. The distribution of risk-factor-attributable disease burden, for example by age or exposure level, can inform the selection and targeting of specific interventions and programs, and increase cost-effectiveness. METHODS AND FINDINGS: For 26 selected risk factors, expert working groups conducted comprehensive reviews of data on risk-factor exposure and hazard for 14 epidemiological subregions of the world, by age and sex. Age-sex-subregion-population attributable fractions were estimated and applied to the mortality and burden of disease estimates from the World Health Organization Global Burden of Disease database. Where possible, exposure levels were assessed as continuous measures, or as multiple categories. The proportion of risk-factor-attributable burden in different population subgroups, defined by age, sex, and exposure level, was estimated. For major cardiovascular risk factors (blood pressure, cholesterol, tobacco use, fruit and vegetable intake, body mass index, and physical inactivity) 43%-61% of attributable disease burden occurred between the ages of 15 and 59 y, and 87% of alcohol-attributable burden occurred in this age group. Most of the disease burden for continuous risks occurred in those with only moderately raised levels, not among those with levels above commonly used cut-points, such as those with hypertension or obesity. Of all disease burden attributable to being underweight during childhood, 55% occurred among children 1-3 standard deviations below the reference population median, and the remainder occurred among severely malnourished children, who were three or more standard deviations below median. CONCLUSIONS: Many major global risks are widely spread in a population, rather than restricted to a minority. Population-based strategies that seek to shift the whole distribution of risk factors often have the potential to produce substantial reductions in dis
182. Defining Substance Use Disorders: Do We Really Need More Than Heavy Use?
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Rehm, J., Marmet, S., Anderson, P., Gual, A., Kraus, L., Nutt, D.J., Room, R., Samokhvalov, A.V., Scafato, E., Trapencieris, M., Wiers, R.W., Gmel, G., Rehm, J., Marmet, S., Anderson, P., Gual, A., Kraus, L., Nutt, D.J., Room, R., Samokhvalov, A.V., Scafato, E., Trapencieris, M., Wiers, R.W., and Gmel, G.
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Aims: The aim of the study was to explore whether the concept of heavy substance use over time can be used as definition of substance use disorder. Methods: Narrative review. Results: Heavy use over time clearly underlies the neurobiological changes associated with current thinking of substance use disorders. In addition, there is evidence that heavy use over time can explain the majority of social problems and of burden of disease (morbidity and mortality). A definition of substance use disorders via heavy use over time would avoid some of the problems of current conceptualizations, for instance the cultural specificity of concepts such as loss of control. Finally, stressing the continuum of use may avoid the high level of stigmatization currently associated with substance use disorders. Conclusion: ‘Heavy substance use over time' seems to be a definition of substance use disorders in line with results of basic research and epidemiology. Additionally, it reduces stigmatization. This approach should thus be further explored
183. What Is Alcohol per Capita Consumption of Adults Telling us about Drinking and Smoking among Adolescents? A Population-Based Study across 68 Countries
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Fuhr, D.C., Gmel, G., Fuhr, D.C., and Gmel, G.
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Aims: To investigate whether recorded alcohol per capita consumption of adults could be linked with alcohol drinking and smoking among adolescents. Methods: Adult alcohol per capita has been plotted graphically together with the prevalence of current drinking and smoking among adolescents. Results: Across all 68 countries, a highly statistically significant correlation was detected, indicating a linear relationship. Conclusion: Countries which are high in alcohol per capita consumption among adults need to pay heightened attention to alcohol and tobacco use among the younger population
184. The Tangible Common Denominator of Substance Use Disorders: A Reply to Commentaries to Rehm et al. (2013a)
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Rehm, J., Anderson, P., Gual, A., Kraus, L., Marmet, S., Nutt, D.J., Room, R., Samokhvalov, A.V., Scafato, E., Shield, K.D., Trapencieris, M., Wiers, R.W., Gmel, G., Rehm, J., Anderson, P., Gual, A., Kraus, L., Marmet, S., Nutt, D.J., Room, R., Samokhvalov, A.V., Scafato, E., Shield, K.D., Trapencieris, M., Wiers, R.W., and Gmel, G.
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In response to our suggestion to define substance use disorders via ‘heavy use over time', theoretical and conceptual issues, measurement problems and implications for stigma and clinical practice were raised. With respect to theoretical and conceptual issues, no other criterion has been shown, which would improve the definition. Moreover, heavy use over time is shown to be highly correlated with number of criteria in current DSM-5. Measurement of heavy use over time is simple and while there will be some underestimation or misrepresentation of actual levels in clinical practice, this is not different from the status quo and measurement of current criteria. As regards to stigma, research has shown that a truly dimensional concept can help reduce stigma. In conclusion, ‘heavy use over time' as a tangible common denominator should be seriously considered as definition for substance use disorder
185. OR14-1PATTERNS AND TRANSITIONS IN SUBSTANCE USE AMONG YOUNG SWISS MEN
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Baggio, S., Studer, J., Gmel, G., Baggio, S., Studer, J., and Gmel, G.
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Introduction. The stages of involvement in illicit drugs other than cannabis remain vague and few studies focused on the last steps of drug-use trajectories. This study investigated this topic. Methods. We used data from the Swiss Longitudinal Cohort Study on Substance Use Risk Factors (C-SURF) to assess exposure to drug use (alcohol, tobacco, 16 illicit drugs including heroin, and five prescription drugs including opioids) at two times point (N = 5,041). Patterns and trajectories of drug use were studied using latent transition analysis (LTA) and cross-lagged panel models. Results. The LTA identified five classes of drug users showing a pattern involving adding alcohol, tobacco, cannabis, middle-stage drugs (uppers, hallucinogens, inhaled drugs), and final-stage drugs (e.g. heroin, ketamine, crystal meth). The most common transition was to remain in the same latent class. Heroin use predicted later opioid use (b = .071, p = .003) but not the reverse (b = -.005, p = .950). Conclusion. The pattern of drug use displayed the well-known sequence of drug involvement (licit drugs/cannabis/other illicit drugs), but added a distinction between "middle-stage" and "final-stage" drugs. Progression along the whole drug course remained rare among participants in their twenties. For the final stage, heroin appeared as to be a step for opioid use
186. A Pre-Post Study on the Appropriateness and Effectiveness of a Web- and Text Messaging-Based Intervention to Reduce Problem Drinking in Emerging Adults
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Haug, Severin, Schaub, Michael P, Venzin, Vigeli, Meyer, Christian, John, Ulrich, and Gmel, Gerhard
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundProblem drinking, particularly risky single-occasion drinking (RSOD), also called “binge drinking”, is widespread among adolescents and young adults in most Western countries. Few studies have tested the effectiveness of interventions to reduce RSOD in young people with heterogeneous and particularly lower educational background. ObjectiveTo test the appropriateness and initial effectiveness of a combined, individually tailored Web- and text messaging (SMS)–based intervention program to reduce problem drinking in vocational school students. MethodsThe fully automated program provided: (1) online feedback about an individual’s drinking pattern compared to the drinking norms of an age- and gender-specific reference group, and (2) recurrent individualized SMS messages over a time period of 3 months. Generalized Estimating Equation (GEE) analyses were used to investigate the longitudinal courses of the following outcomes over the study period of 3 months: RSOD, alcohol-related problems, mean number of standard drinks per week, and maximum number of standard drinks on an occasion. ResultsThe program was tested in 36 school classes at 7 vocational schools in Switzerland. Regardless of their drinking behavior, 477 vocational school students who owned a mobile phone were invited to participate in the program. Of these, 364 (76.3%) participated in the program. During the intervention period, 23 out of 364 (6.3%) persons unsubscribed from participating in the program. The GEE analyses revealed decreases in the percentage of persons with RSOD from baseline (75.5%, 210/278) to follow-up assessment (67.6%, 188/278, P
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- 2013
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187. Research and the alcohol industry.
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GMEL, G., HEEB, J. L., and REHM, J.
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LETTERS to the editor , *ALCOHOL industry - Abstract
Presents a letter to the editor about research and alcohol industry published in the December 2003 issue of the journal "Addiction."
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- 2003
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188. Using Severity-adjusted Symptom Scores Suggests There is No Dimensional Structure Underlying DSM-IV Symptoms of Depression.
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Foster, S., Gmel, G., Estévez, N., and Mohler-Kuo, M.
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DIAGNOSIS of mental depression , *HEALTH & Nutrition Examination Survey , *MENTAL depression , *THERAPEUTICS , *HYPOTHESIS , *STATISTICAL correlation - Abstract
Introduction Previous research failed to uncover a replicable structure of dimensions or subtypes underlying the symptoms of depression. One reason might be that research failed to separate co-variation between symptoms due to overall depression severity vs. due to specific symptom profiles. Objectives and Aims The study tested the hypothesis that a replicable dimensional structure of depression would be uncovered when depression severity is eliminated from symptom scores. Additionally, the study explored differences in the dimensional structure in general population vs. depressed people-only samples. Methods The cohort study on substance use risk factors (C-SURF), a large cohort of young Swiss men, and young men from the national health and nutrition survey in the US (NHANES 2009-2012) were analyzed. DSM-IV symptoms of depression were assessed via the Major Depressive Inventory (WHO-MDI) in C-SURF and via the Patient Health Questionnaire 9 (PHQ-9) in NHANES. Dimensionality was examined using principal component analysis in full samples vs. samples of participants with a current depressive episode for raw vs. severity-adjusted symptom scores. Results When using severity-adjusted symptom scores, correlations between depressive symptoms largely disappeared and there were no replicable dimensions. When using raw scores in the full samples, one single dimension of depression consistently emerged. When using raw scores in depressed participants, only rudiments of dimensions were found across samples. Conclusions It is unlikely that there are stable dimensions underlying the DSM-IV symptoms of depression. The set of symptoms capture the disorder in the general population, but the disorder's manifestation is highly individual. [ABSTRACT FROM AUTHOR]
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- 2015
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189. Alcohol and cannabis use as risk factors for injury--a case-crossover analysis in a Swiss hospital emergency department.
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Gmel G, Kuendig H, Rehm J, Schreyer N, Daeppen JB, Gmel, Gerhard, Kuendig, Hervé, Rehm, Jürgen, Schreyer, Nicolas, and Daeppen, Jean-Bernard
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Background: There is sufficient and consistent evidence that alcohol use is a causal risk factor for injury. For cannabis use, however, there is conflicting evidence; a detrimental dose-response effect of cannabis use on psychomotor and other relevant skills has been found in experimental laboratory studies, while a protective effect of cannabis use has also been found in epidemiological studies.Methods: Implementation of a case-crossover design study, with a representative sample of injured patients (N = 486; 332 men; 154 women) from the Emergency Department (ED) of the Lausanne University Hospital, which received treatment for different categories of injuries of varying aetiology.Results: Alcohol use in the six hours prior to injury was associated with a relative risk of 3.00 (C.I.: 1.78, 5.04) compared with no alcohol use, a dose-response relationship also was found. Cannabis use was inversely related to risk of injury (RR: 0.33; C.I.: 0.12, 0.92), also in a dose-response like manner. However, the sample size for people who had used cannabis was small. Simultaneous use of alcohol and cannabis did not show significantly elevated risk.Conclusion: The most surprising result of our study was the inverse relationship between cannabis use and injury. Possible explanations and underlying mechanisms, such as use in safer environments or more compensatory behavior among cannabis users, were discussed. [ABSTRACT FROM AUTHOR]- Published
- 2009
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190. Modeling the impact of alcohol dependence on mortality burden and the effect of available treatment interventions in the European Union
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Rehm, J., Shield, K.D., Gmel, G., Rehm, M.X., and Frick, U.
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ALCOHOLISM , *ALCOHOL drinking , *DISEASE risk factors , *MORTALITY , *SYSTEMATIC reviews - Abstract
Abstract: Alcohol consumption is a major risk factor for the burden of disease, and Alcohol Dependence (AD) is the most important disorder attributable to this behavior. The objective of this study was to quantify mortality associated with AD and the potential impact of treatment. For the EU countries, for the age group 15–64 years, mortality attributable to alcohol consumption in general, to heavy drinking, and to AD were estimated based on the latest data on exposure and mortality. Potential effects of AD treatment were modeled based on Cochrane and other systematic reviews of the effectiveness of the best known and most effective interventions. In the EU 88.9% of men and 82.1% of women aged 15–64 years were current drinkers; and 15.3% of men and 3.4% of women in this age group were heavy drinkers. AD affected 5.4% of men and 1.5% of women. The net burden caused by alcohol consumption was 1 in 7 deaths in men and 1 in 13 deaths in women. The majority of this burden was due to heavy drinking (77%), and 71% of this burden was due to AD. Increasing treatment coverage for the most effective treatments to 40% of all people with AD was estimated to reduce alcohol-attributable mortality by 13% for men and 9% for women (annually 10,000 male and 1700 female deaths avoided). Increasing treatment rates for AD was identified as an important issue for future public health strategies to reduce alcohol-attributable harm and to complement the current focus of alcohol policy. [Copyright &y& Elsevier]
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- 2013
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191. Acute and usual drinking among emergency trauma patients: a study on alcohol consumption and injury patterns.
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Kuendig, H., Hasselberg, M., Gmel, G., Daeppen, J.-B., and Laflamme, L.
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ALCOHOL drinking , *PATIENTS , *MEDICAL emergencies , *SPORTS medicine , *CLUSTER analysis (Statistics) , *WOUNDS & injuries - Abstract
OBJECTIVE: To investigate the relationship between usual and acute alcohol consumption among injured patients and, when combined, how they covary with other injury attributes. METHODS: Data from a randomised sample of 486 injured patients interviewed in an emergency department (Lausanne University Hospital, Switzerland) were analysed using the χ2test for independence and cluster analysis. RESULTS: Acute alcohol consumption (24.7%) was associated with usual drinking and particularly with high volumes of consumption. Six injury clusters were identified. Over-representations of acute consumption were found in a cluster typical of injuries sustained through interpersonal violence and in another formed by miscellaneous circumstances. A third cluster, typical of sports injuries, was linked to a group of frequent heavy episodic drinkers (without acute consumption). CONCLUSIONS: Among injured patients, acute alcohol consumption is common and associated with usual drinking. Acute and/or usual consumption form part of some, but not all, injury clusters. [ABSTRACT FROM AUTHOR]
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- 2009
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192. Patterns of Alcohol Consumption and Acute Myocardial Infarction: A Case-Crossover Analysis.
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Gerlich, M. G., Krämer, A., Gmel, G., Maggiorini, M., Lüscher, T. F., Rickli, H., Kleger, G. R., and Rehm, J.
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ALCOHOL drinking , *CORONARY disease , *ALCOHOLISM , *BINGE drinking , *MYOCARDIAL infarction - Abstract
Background: Alcohol consumption has been causally related to the incidence of coronary heart disease, but the role of alcohol before the event has not been explored in depth. This study tested the hypothesis that heavy drinking (binge drinking) increases the risk of subsequent acute myocardial infarctions (AMI), whereas light to moderate drinking occasions decrease the risk. Methods: Case-crossover design of 250 incident AMI cases in Switzerland, with main hypotheses tested by conditional logistic regression. Results: Alcohol consumption 12 h before the event significantly increased the risk of AMI (OR 3.1; 95% CI 1.4–6.9). Separately, the effects of moderate and binge drinking before the event on AMI were of similar size but did not reach significance. In addition, AMI patients showed more binge drinking than comparable control subjects from the Swiss general population. Conclusions: We found no evidence that alcohol consumption before the event had protective effects on AMI. Instead, alcohol consumption increased the risk. Copyright © 2009 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
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- 2009
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193. Social roles and alcohol consumption: a study of 10 industrialised countries.
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Kuntsche S, Knibbe RA, and Gmel G
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The empirical evidence as regards the precise associations between alcohol use and social roles, and these associations across genders and cultures is heterogeneous. The literature tends to focus on two central but conflicting theories. The first - classic role theory - assumes that a higher number of social roles is associated with a more structured life and thus fewer opportunities to drink heavily. The second - the multiple burden hypothesis - posits that the increasing complexity of multiple social roles leads to higher stress levels, and thus to increased alcohol use. Survey data on 25-54-year olds in 10 western industrialised countries which participate in the Gender, Alcohol and Culture: An International Study (GenACIS) project were used to test whether holding the three main social roles - partnership, parenthood, and paid labour - had a more protective or a more detrimental association with problematic alcohol use than holding fewer roles. Age and education were included as possible confounders, while the outcome variables were risky single occasion drinking (RSOD) and heavy-volume drinking. For both men and women and in almost all countries, the study found that those who had all three roles were least likely to drink heavily or engage in RSOD, thus supporting the assumptions of classic role theory. It also found that the protective effect of multiple roles was more consistent for RSOD. There were a few countries where a two-role model gave a better fit. Results for Germany (RSOD), Switzerland, and the Unites States (heavy-volume drinking) indicate that the role of paid labour appears to be particularly relevant for risky alcohol use among women. Despite some variability in the association between paid labour and heavy drinking or RSOD among women, in almost all countries the greater the number of roles a person held, the lower their risk of this type of alcohol use was. [ABSTRACT FROM AUTHOR]
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- 2009
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194. How to screen for problematic cannabis use in population surveys. An Evaluation of the Cannabis Use Disorders Identification Test (CUDIT) in a Swiss sample of adolescents and young adults.
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Annaheim B, Rehm J, and Gmel G
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- 2008
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195. Characteristics of binge drinkers in Europe
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Kuntsche, E., Rehm, J., and Gmel, G.
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BINGE drinking , *SOCIAL status , *DEMOGRAPHY , *PSYCHOTHERAPY , *TEENAGERS , *YOUNG adults - Abstract
Binge drinking has been shown to be associated with considerable social harm and disease burden. This review aims to give an overview from a European perspective of the socio-demographical, individual, and social factors that affect binge drinking and to identify effective interventions to reduce binge drinking. To this end, a computer-assisted search of relevant articles was conducted. Results showed that males tended to binge drinking more frequently than females. Binge drinking was most prevalent among adolescents and young adults, and prevalence levelled off later in life. Socio-economic conditions seemed to have an effect on binge drinking, independent of their effects on the volume of alcohol consumed. The early onset of binge drinking was associated with a history of drinking in the family, but pathways into adulthood are less clear. Binge drinking often co-occurred with other substance use. Motives for binge drinking included both social camaraderie and tension reduction. Which aspect prevails may vary according to the type of binge drinker, but to date has not been satisfactorily explained. Binge drinkers were not likely to know enough about or be aware of the potential risks of bingeing. Pressure from peers was one of the strongest influencing factors for binge drinking and seemed to outweigh parental influences, especially from late adolescence onwards. Binge drinking also varied according to both the predominant adult and adolescent drinking culture with more binge drinking in the northern and middle parts of Europe compared to the southern parts. Thus, a variety of socio-demographical, individual, and social characteristics associated with binge drinking have been identified. However, knowledge in this area is limited, as most research has been conducted among particular groups in specific situations, in particular North American college students. More research in Europe is urgently needed, as results from other cultural backgrounds are difficult to generalize. [Copyright &y& Elsevier]
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- 2004
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196. International comparisons of alcohol consumption.
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Bloomfield K, Stockwell T, Gmel G, and Rehn N
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International comparisons of alcohol consumption and its consequences can serve multiple purposes. For example, despite differences among countries in drinking cultures, drink sizes and strengths, and methods of measuring alcohol consumption, international survey research has provided a substantial amount of information on the rates of abstinence or current drinking, the frequency of drinking or binge drinking, and the mean consumption among both adults and youths in many countries. Other studies using aggregate-level data have analyzed per capita alcohol consumption in various countries. These studies can be used to relate per capita consumption to certain alcohol-related outcomes and to evaluate changes of both consumption and different outcomes within a country or across countries over time. Some problems associated with international research, however, such as issues of comparability of surveys, still need to be resolved. [ABSTRACT FROM AUTHOR]
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- 2003
197. Psychological impact of the COVID-19 crisis on young swiss men participating in a cohort study: Differences due to socioeconomic status and work situation.
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Marmet, S., Wicki, M., Gmel, G., Gachoud, C., Bertholet, N., and Studer, J.
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COVID-19 pandemic , *PSYCHOLOGICAL factors , *SOCIOECONOMIC status , *EMOTIONAL trauma , *SLEEP quality , *TELECOMMUTING - Abstract
Introduction: The COVID-19 pandemic impacted daily life worldwide. It may also have had a psychological impact, especially on those with less resources already before the crisis and those who reported substantial changes to their work situation. Objectives: To investigate whether socioeconomic status before the crisis and changes in work situation during the crisis (unemployment, home-office) are associated with psychological impact in a cohort of young Swiss men. Methods: A total of 2345 young Swiss men (mean age = 29) completed assessments shortly before (April 2019 to February 2020) and early during the COVID-19 crisis (May to June 2020). Assessments covered psychological outcomes assessed before and during COVID-19 crisis (depression, perceived stress and sleep quality), and assessed during the crisis (fear, isolation and COVID-19 psychological trauma), socioeconomic status (relative financial status and difficulty to pay bills) before the crisis and changes in work situation (unemployment, home-office). Results: About a fifth of the sample were in partial unemployment or lost their job during COVID-19 crisis. Those in partial or full unemployment, those mostly working from home and those with a lower socioeconomic status already prior to the crisis showed overall higher levels of depression, stress, psychological trauma, fear and isolation. Conclusions: Even in a country with high social security such as Switzerland, the COVID-19 crisis had a higher psychological impact on those who were already disadvantaged before the crisis or experienced deteriorations in their work situation. Supporting disadvantaged subpopulations during the crisis may help to prevent an amplification of pre-existing inequalities. [ABSTRACT FROM AUTHOR]
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- 2021
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198. Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study
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Antonio Agudo, Carla H. van Gils, Naomi E. Allen, Miren Dorronsoro, Tobias Pischon, Christina C. Dahm, Antonia Trichopoulou, Madlen Schütze, Sabine Rohrmann, Tara Kehoe, Nadia Slimani, Nicholas J. Wareham, Aurelio Barricarte, Paolo Boffetta, Kim Overvad, Rudolf Kaaks, Petra H.M. Peeters, María José Sánchez, Jürgen Rehm, Anja Olsen, Gerrit Gmel, Laudina Rodríguez, Manuela M. Bergmann, Françoise Clavel-Chapelon, Heiner Boeing, Franco Berrino, Petra A. Wark, Mazda Jenab, Elio Riboli, María Dolores Chirlaque, Vasiliki Benetou, Anne Tjønneland, Dora Romaguera, Kay-Tee Khaw, Rosario Tumino, Paolo Vineis, Marie-Christine Boutron-Ruault, Dimosthenis Zylis, Domenico Palli, Timothy J. Key, Schütze, M., Boeing, H., Pischon, T., Rehm, J., Kehoe, T., Gmel, G., Olsen, A., Tjønneland, A.M., Dahm, C.C., Overvad, K., Clavel-Chapelon, F., Boutron-Ruault, M.C., Trichopoulou, A., Benetou, V., Zylis, D., Kaaks, R., Rohrmann, S., Palli, D., Berrino, F., Tumino, R., Vineis, P., Rodríguez, L., Agudo, A., Sánchez, M.J., Dorronsoro, M., Chirlaque, M.D., Barricarte, A., Peeters, P.H., van Gils, C.H., Khaw, K.T., Wareham, N., Allen, N.E., Key, T.J., Boffetta, P., Slimani, N., Jenab, M., Romaguera, D., Wark, P.A., Riboli, E., Bergmann, M.M., [Schuetze,M, Boeing,H, Pischon,T, Bergmann,MM.] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany. [Rehm,J, Kehoe,T, Gmel,G] CAMH, Toronto, ON, Canada. [Rehm, J] Tech Univ Dresden, Inst Clin Psychol & Psychotherapy, Dresden, Germany. [Olsen,A, Tjonneland,AM.] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark. [Dahm,CC] Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark. [Overvad,K] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark. [Clavel-Chapelon,F, Boutron-Ruault,M-C] Inst Gustave Roussy, Ctr Res Epidemiol & Populat Hlth,Villejuif, France. [Clavel-Chapelon,F, Boutron-Ruault,MC] Paris S Univ, UMRS 1018, Villejuif, France. [Trichopoulou, A, Benetou,V, Zylis,D] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, Athens, Greece. [Kaaks,R, Rohrmann,S] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany. [Palli,D] Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy. [Berrino, Franco] Fdn IRCCS Ist Nazl Tumori, Dept Prevent & Predict Med, Epidemiol Unit, Milan, Italy. [Tumino,R] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy. [Vineis, Paolo] Inst Sci Interchange Fdn, Turin, Italy. [Rodriguez,L] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain. [Tumino,R] Civile MP Arezzo Hosp, Histopathol Unit, Ragusa, Italy. [Agudo,A] Catalan Inst Oncol IDIBELL, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain. [Sanchez,MJ] Andalusian Sch Publ Hlth, Granada, Spain. [Sanchez,MJ, Dorronsoro,M, Chirlaque,MD, Barricarte,A] CIBERESP, San Sebastian, Spain. [Dorronsoro, Miren] Publ Hlth Dept Gipuzkoa, San Sebastian, Spain. [Chirlaque,MD] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain. [Peeters,PH., van Gils,CH.] Univ Med Ctr, Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. [Khaw,K_T] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England. [Wareham,N] MRC, Epidemiol Unit, Cambridge, England. [Allen,NE., Key,TJ.] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, England. [Boffetta, P, Slimani,N, Jenab,M] Int Agcy Res Canc, Lyon, France. [Boffetta,P] Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA. [Vineis,P, Romaguera,D, Wark,PA., Riboli,E] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England., The work was performed (partly) within the coordinated action EPIC (SP23-CT-2005-006438), which has received research funding from the Community’s Sixth Framework Programme, as well as by the 'Europe Against Cancer' Programme of the European Commission (SANCO), Deutsche Krebshilfe, German Cancer Research Center, German Federal Ministry of Education and Research, Danish Cancer Society, Health Research Fund (FIS) of the Spanish Ministry of Health (grant No: Network RCESP C03/09), Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra, ISCIII, Red de Centros RETIC(RD06/0020) (grant No: C03/09), Cancer Research UK, Medical Research Council, UK, Stroke Association, UK, British Heart Foundation, Department of Health, UK, Food Standards Agency, UK, Wellcome Trust, UK, Italian Association for Research on Cancer (AIRC), Compagnia di San Paolo, Progetto Integrato Oncologia-PIO, Regione Toscana, Dutch Ministry of Public Health, Welfare and Sports, National Cancer Registry of the Netherlands, Greek Ministry of Health and Social Solidarity, and Hellenic Health Foundation and Stavros Niarchos Foundation
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Male ,Alcohol drinking ,Alcohol use disorder ,burden ,0302 clinical medicine ,Breast cancer ,Cost of Illness ,Neoplasms ,Medicine ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,Health Education ,General Environmental Science ,Colon Cancer ,Incidence (epidemiology) ,Hazard ratio ,General Engineering ,General Medicine ,cohort ,Middle Aged ,Diseases::Neoplasms [Medical Subject Headings] ,Consumo de bebidas alcohólicas ,3. Good health ,European Prospective Investigation into Cancer and Nutrition ,Colon cancer ,Europe ,Oncology ,030220 oncology & carcinogenesis ,Female ,Incidencia ,Alcohol ,Cohort study ,Adult ,medicine.medical_specialty ,Alcohol Drinking ,Health Promotion ,03 medical and health sciences ,Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings] ,Breast Cancer ,Humans ,cancer ,Sex Distribution ,Aged ,Health Care::Health Care Facilities, Manpower, and Services::Health Services::Preventive Health Services::Health Education [Medical Subject Headings] ,business.industry ,Research ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques [Medical Subject Headings] ,prospective ,medicine.disease ,Surgery ,Epidemiologic Studies ,Cardiovascular and Metabolic Diseases ,Relative risk ,attributable ,Attributable risk ,Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking [Medical Subject Headings] ,incidence ,General Earth and Planetary Sciences ,Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence [Medical Subject Headings] ,business ,Quantitative research ,Demography - Abstract
Objective To compute the burden of cancer attributable to current and former alcohol consumption in eight European countries based on direct relative risk estimates from a cohort study. Design Combination of prospective cohort study with representative population based data on alcohol exposure. Setting Eight countries (France, Italy, Spain, United Kingdom, the Netherlands, Greece, Germany, Denmark) participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Participants 109 118 men and 254 870 women, mainly aged 37-70. Main outcome measures Hazard rate ratios expressing the relative risk of cancer incidence for former and current alcohol consumption among EPIC participants. Hazard rate ratios combined with representative information on alcohol consumption to calculate alcohol attributable fractions of causally related cancers by country and sex. Partial alcohol attributable fractions for consumption higher than the recommended upper limit (two drinks a day for men with about 24 g alcohol, one for women with about 12 g alcohol) and the estimated total annual number of cases of alcohol attributable cancer. Results If we assume causality, among men and women, 10% (95% confidence interval 7 to 13%) and 3% (1 to 5%) of the incidence of total cancer was attributable to former and current alcohol consumption in the selected European countries. For selected cancers the figures were 44% (31 to 56%) and 25% (5 to 46%) for upper aerodigestive tract, 33% (11 to 54%) and 18% (−3 to 38%) for liver, 17% (10 to 25%) and 4% (−1 to 10%) for colorectal cancer for men and women, respectively, and 5.0% (2 to 8%) for female breast cancer. A substantial part of the alcohol attributable fraction in 2008 was associated with alcohol consumption higher than the recommended upper limit: 33 037 of 178 578 alcohol related cancer cases in men and 17 470 of 397 043 alcohol related cases in women. Conclusions In western Europe, an important proportion of cases of cancer can be attributable to alcohol consumption, especially consumption higher than the recommended upper limits. These data support current political efforts to reduce or to abstain from alcohol consumption to reduce the incidence of cancer.
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- 2011
199. Changes in living arrangement, daily smoking, and risky drinking initiation among young Swiss men: a longitudinal cohort study.
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Bähler, C., Foster, S., Estevez, N., Dey, M., Gmel, G., and Mohler-Kuo, M.
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ALCOHOLIC beverages , *TOBACCO products , *FAMILIES , *PATIENT aftercare , *LONGITUDINAL method , *PARENTS , *PEER pressure , *SMOKING , *MULTIPLE regression analysis , *SIGNIFICANT others , *SOCIAL support , *DESCRIPTIVE statistics , *ODDS ratio , *ECONOMICS - Abstract
Objectives: The aim of this study was to assess the association between changes in living arrangement and the initiation of daily smoking and monthly risky single-occasion drinking (RSOD) in a cohort of young Swiss men. Study design: Longitudinal cohort study. Methods: The sample consisted of 4662 young men drawn from the Cohort Study on Substance Use Risk Factors who lived with their family at baseline. Follow-up assessments occurred 15 months later. Multiple regression models were adjusted for individual and family factors (family model), as well as for individual and peer-related factors (peer model). Results: Relative to those still living with their parents at follow-up (n = 3845), those who had moved out (n = 817) were considerably more likely to have taken up smoking or RSOD after adjusting for several individual, family, and peer-related variables: OR (daily smoking) = 1.67 (95% CI 1.15-2.41) (P = 0.007) and OR (monthly RSOD) = 1.42 (95% CI 1.08 -1.88) (P = 0.012). The strongest family-related predictors of smoking initiation were family structure and the lack of parental regulation and the strongest peer-related factors alcohol/drug problems in peers. Meanwhile, the strongest peer-related predictors of RSOD initiation were peer pressure (misconduct), perceived social support from friends, and perceived social support from a significant other, whereas family factors were not associated with RSOD initiation. Further subanalyses were conducted to examine the impact of different living arrangement changes on substance use initiation and revealed that living with peers at follow-up was associated with the greatest risk. Conclusions: We identified a strong association between moving out of one's parents' home and daily smoking and monthly RSOD initiation in young Swiss men. Moving out to live with peers was an especially strong predictor of substance use initiation. Campaigns that aim to prevent heavy smoking and drinking should be intensified at the end of obligatory school. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
200. Behavioural addictions as risk factors for incidence and reoccurrence of suicide ideation and attempts in a prospective cohort study among young swiss men.
- Author
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Wicki, M., Andronicos, M., Studer, J., Marmet, S., and Gmel, G.
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ADDICTIONS , *ATTEMPTED suicide , *SUICIDAL ideation , *MARIJUANA abuse , *ALCOHOLISM , *COMPULSIVE behavior - Abstract
Introduction: Substance use disorder, depression and sexual minority are well documented risk factors for suicidal behaviour, far less is known about behavioural addictions. Objectives: First, to explore associations between behavioural addictions (gaming, gambling, cybersex, internet, smartphone, work) at age 25 and the incidence and reoccurrence of suicide ideation (SID), suicide attempts (SAT), and suicide attempts among those with suicide ideation (SATID) at age 28. Second, to test whether these associationswere impacted by adjusting for cannabis and alcohol use disorder, nicotine dependence, sexual orientation and depression. Methods: Based on two waves of a prospective cohort study of 5,428 young Swiss men, nested models with and without adjustment for risk factors were used to regress SID, SAT and SATID on preceding behavioural addictions. Results: Without adjustment, each of the behavioural addictions at age 25 significantly predicted the incidence of SIDand SAT at age 28. Gambling and cybersex addiction furthermore predicted SATID. When adjusting for other risk factors, associations with behavioural addictions were reduced, whereas depression and cannabis use disorder were the most important and consistent predictors for the incidence and recurrence of SID, SAT and SATID. Conclusions: Among young Swiss men, behavioural addictions are important predictors of SID and SAT, however a large part of their association is shared with depression and cannabis use disorder. Treatment for addictive behaviors, especially cannabis use can open the door to larger mental health screening and targeted intervention. Crisis intervention among men presenting addictive behaviours with or without substance may therefore be key to preventing suicidal behaviour. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
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