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151. Targeted Assessment of G0S2 Methylation Identifies a Rapidly Recurrent, Routinely Fatal Molecular Subtype of Adrenocortical Carcinoma

Author

Mohan, Dipika R., primary, Lerario, Antonio Marcondes, additional, Else, Tobias, additional, Mukherjee, Bhramar, additional, Almeida, Madson Q., additional, Vinco, Michelle, additional, Rege, Juilee, additional, Mariani, Beatriz M. P., additional, Zerbini, Maria Claudia N., additional, Mendonca, Berenice B., additional, Latronico, Ana Claudia, additional, Marie, Suely K. N., additional, Rainey, William E., additional, Giordano, Thomas J., additional, Fragoso, Maria Candida B. V., additional, and Hammer, Gary D., additional

Published
2019
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152. Interobserver Variability in the Histopathologic Assessment of Extrathyroidal Extension of Well Differentiated Thyroid Carcinoma Supports the New American Joint Committee on Cancer Eighth Edition Criteria for Tumor Staging

Author

Turk, Andrew T., primary, Asa, Sylvia L., additional, Baloch, Zubair W., additional, Faquin, William C., additional, Fellegara, Giovanni, additional, Ghossein, Ronald A., additional, Giordano, Thomas J., additional, LiVolsi, Virginia A., additional, Lloyd, Ricardo, additional, Mete, Ozgur, additional, Rosai, Juan, additional, Suster, Saul, additional, Thompson, Lester D.R., additional, and Wenig, Bruce M., additional

Published
2019
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153. Adjuvant Radiation Improves Recurrence-Free Survival and Overall Survival in Adrenocortical Carcinoma

Author

Gharzai, Laila A, primary, Green, Michael D, additional, Griffith, Kent A, additional, Else, Tobias, additional, Mayo, Charles S, additional, Hesseltine, Elizabeth, additional, Spratt, Daniel E, additional, Ben-Josef, Edgar, additional, Sabolch, Aaron, additional, Miller, Barbara S, additional, Worden, Francis, additional, Giordano, Thomas J, additional, Hammer, Gary D, additional, and Jolly, Shruti, additional

Published
2019
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155. Somatic mutations in adrenocortical carcinoma with primary aldosteronism or hyperreninemic hyperaldosteronism

Author

Mouat, Isobel C, primary, Omata, Kei, additional, McDaniel, Andrew S, additional, Hattangady, Namita G, additional, Talapatra, Debnita, additional, Cani, Andi K, additional, Hovelson, Daniel H, additional, Tomlins, Scott A, additional, Rainey, William E, additional, Hammer, Gary D, additional, Giordano, Thomas J, additional, and Else, Tobias, additional

Published
2019
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161. Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data

Author

Gruber Stephen B, Giordano Thomas J, Cho Kathleen R, Macdonald James, Ghosh Debashis, Kuick Rork, Chen Wei, Shedden Kerby, Fearon Eric R, Taylor Jeremy MG, and Hanash Samir

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5
Abstract

Abstract Background A critical step in processing oligonucleotide microarray data is combining the information in multiple probes to produce a single number that best captures the expression level of a RNA transcript. Several systematic studies comparing multiple methods for array processing have used tightly controlled calibration data sets as the basis for comparison. Here we compare performances for seven processing methods using two data sets originally collected for disease profiling studies. An emphasis is placed on understanding sensitivity for detecting differentially expressed genes in terms of two key statistical determinants: test statistic variability for non-differentially expressed genes, and test statistic size for truly differentially expressed genes. Results In the two data sets considered here, up to seven-fold variation across the processing methods was found in the number of genes detected at a given false discovery rate (FDR). The best performing methods called up to 90% of the same genes differentially expressed, had less variable test statistics under randomization, and had a greater number of large test statistics in the experimental data. Poor performance of one method was directly tied to a tendency to produce highly variable test statistic values under randomization. Based on an overall measure of performance, two of the seven methods (Dchip and a trimmed mean approach) are superior in the two data sets considered here. Two other methods (MAS5 and GCRMA-EB) are inferior, while results for the other three methods are mixed. Conclusions Choice of processing method has a major impact on differential expression analysis of microarray data. Previously reported performance analyses using tightly controlled calibration data sets are not highly consistent with results reported here using data from human tissue samples. Performance of array processing methods in disease profiling and other realistic biological studies should be given greater consideration when comparing Affymetrix processing methods.

Published
2005
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163. Somatic Mutation As a Cause of Aldosterone-Producing Adenoma.

Author

Nanba, Kazutaka, Blinder, Amy R., Rege, Juilee, Hattangady, Namita G., Else, Tobias, Liu, Chia-Jen, Tomlins, Scott A., Vats, Pankaj, Kumar-Sinha, Chandan, Giordano, Thomas J., and Rainey, William E.

Abstract

Driver somatic mutations for aldosterone excess have been found in ≈90% of aldosterone-producing adenomas (APAs) using an aldosterone synthase (CYP11B2)-guided sequencing approach. In the present study, we identified a novel somatic CACNA1H mutation (c.T4289C, p.I1430T) in an APA without any currently known aldosterone-driver mutations using CYP11B2 immunohistochemistry-guided whole exome sequencing. The CACNA1H gene encodes a voltage-dependent T-type calcium channel alpha-1H subunit. Germline variants in this gene are known as a cause of familial hyperaldosteronism IV. Targeted next-generation sequencing detected identical CACNA1H variants in 2 additional APAs in a cohort of the University of Michigan, resulting in a prevalence of 4% (3/75) in APAs. We tested the functional effect of the variant on adrenal cell aldosterone production and CYP11B2 mRNA expression using the human adrenocortical HAC15 cell line with a doxycycline-inducible CACNA1HI1430T mutation. Doxycycline treatment increased CYP11B2 mRNA levels as well as aldosterone production, supporting a pathological role of the CACNA1H p.I1430T mutation on the development of primary aldosteronism. In conclusion, somatic CACNA1H mutation is a genetic cause of APAs. Although the prevalence of this mutation is low, this study will provide better understanding of molecular mechanism of inappropriate aldosterone production in APAs. [ABSTRACT FROM AUTHOR]

Published
2020
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164. Funding anatomic pathology research: a retrospective analysis of an intramural funding mechanism

Author

McDaniel, Andrew, Fullen, Douglas R., Cho, Kathleen R., Lucas, David R., Giordano, Thomas J., Greenson, Joel, Lieberman, Andrew P., Kunju, Lakshmi P., Myers, Jeffrey L., and Roh, Michael H.

Subjects
Research grants -- Reports, Pathology -- Research, Health
Abstract

Context.--In 2006, the department of pathology at our institution established an intramural research funding mechanism to support anatomic pathology research projects for faculty and trainee development. A review committee consisting of faculty members with diverse academic interests evaluated applications; proposals were eligible for a maximum award amount of $30 000 per project with a maximum program cost of $150 000 annually. Objective.--To report our experience based on a retrospective review of the research proposals submitted to the committee since the inception of the Anatomic Pathology Research Fund and evaluate the outcomes of the funded projects. Design.--We retrospectively analyzed all project applications that were received by the committee. Outcome data were collected by reviewing progress reports, abstracts for national and international meetings, PubMed search results, and/or direct communication with investigators. Results.--To date, a total of 59 individual projects have been awarded funding, for a total amount of $349 792, with an average award amount of $5381 per project. A total of 26 faculty members have secured funding for projects through this mechanism, and 27 resident and fellow trainees have been engaged in the funded projects. Spanning 11 subspecialty disciplines in anatomic pathology, 32 abstracts (54%) have been presented at national meetings and 26 (44%) have been published in the peer-reviewed literature to date. One project generated data used to secure an extramural (R01) grant. Conclusions.--Our funding mechanism could serve as a model used by other academic departments to support research activities, thereby fostering faculty development through scholarly activities. (Arch Pathol Lab Med. 2013;137:1270-1273; doi: 10.5858/arpa.2012-0546-OA), Academic pathology represents a unique specialty in medicine owing to the diversity of academic and scholarly activities that can be performed. (1) Research in anatomic pathology represents a proportion of [...]

Published
2013
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165. Transcriptional targeting of oncogene addiction in medullary thyroid cancer

Author

Valenciaga, Anisley, primary, Saji, Motoyasu, additional, Yu, Lianbo, additional, Zhang, Xiaoli, additional, Bumrah, Ceimoani, additional, Yilmaz, Ayse S., additional, Knippler, Christina M., additional, Miles, Wayne, additional, Giordano, Thomas J., additional, Cote, Gilbert J., additional, and Ringel, Matthew D., additional

Published
2018
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171. The utility of SDHB and FH immunohistochemistry in patients evaluated for hereditary paraganglioma-pheochromocytoma syndromes

Author

Udager, Aaron M., primary, Magers, Martin J., additional, Goerke, Dayna M., additional, Vinco, Michelle L., additional, Siddiqui, Javed, additional, Cao, Xuhong, additional, Lucas, David R., additional, Myers, Jeffrey L., additional, Chinnaiyan, Arul M., additional, McHugh, Jonathan B., additional, Giordano, Thomas J., additional, Else, Tobias, additional, and Mehra, Rohit, additional

Published
2018
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172. Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells

Author

Sundaresan, Sinju, primary, Meininger, Cameron A., additional, Kang, Anthony J., additional, Photenhauer, Amanda L., additional, Hayes, Michael M., additional, Sahoo, Nirakar, additional, Grembecka, Jolanta, additional, Cierpicki, Tomasz, additional, Ding, Lin, additional, Giordano, Thomas J., additional, Else, Tobias, additional, Madrigal, David J., additional, Low, Malcolm J., additional, Campbell, Fiona, additional, Baker, Ann-Marie, additional, Xu, Haoxing, additional, Wright, Nicholas A., additional, and Merchant, Juanita L., additional

Published
2017
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173. Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

Author

Pathologie Pathologen staf, Onderzoeksgroep 6, Fishbein, Lauren, Leshchiner, Ignaty, Walter, Vonn, Danilova, Ludmila, Robertson, A. Gordon, Johnson, Amy R., Lichtenberg, Tara M., Murray, Bradley A., Ghayee, Hans K., Else, Tobias, Ling, Shiyun, Jefferys, Stuart R., de Cubas, Aguirre A., Wenz, Brandon, Korpershoek, Esther, Amelio, Antonio L., Makowski, Liza, Rathmell, W. Kimryn, Gimenez-Roqueplo, Anne Paule, Giordano, Thomas J., Asa, Sylvia L., Tischler, Arthur S., Akbani, Rehan, Ally, Adrian, Amar, Laurence, Arachchi, Harindra, Auchus, Richard J., Auman, J. Todd, Baertsch, Robert, Balasundaram, Miruna, Balu, Saianand, Bartsch, Detlef K., Baudin, Eric, Bauer, Thomas, Beaver, Allison, Benz, Christopher, Beroukhim, Rameen, Beuschlein, Felix, Bodenheimer, Tom, Boice, Lori, Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Carter, Suzie, Cassol, Clarissa A., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cope, Leslie, Crain, Daniel, Curley, Erin, de Krijger, Ronald R., Demchok, John A., Deutschbein, Timo, Dhalla, Noreen, Dimmock, David, Dinjens, Winand N M, Eng, Charis, Eschbacher, Jennifer, Fassnacht, Martin, Felau, Ina, Feldman, Michael, Ferguson, Martin L., Fiddes, Ian, Frazer, Scott, Gabriel, Stacey B., Gardner, Johanna, Gastier-Foster, Julie M., Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Geurts, Jennifer, Goldman, Mary, Graim, Kiley, Gupta, Manaswi, Haan, David, Hahner, Stefanie, Hantel, Constanze, Haussler, David, Hayes, D. Neil, Heiman, David I., Hoadley, Katherine A., Holt, Robert A., Hoyle, Alan P., Huang, Mei, Hunt, Bryan, Hutter, Carolyn M., Jones, Steven J M, Jones, Corbin D., Kasaian, Katayoon, Kebebew, Electron, Kim, Jaegil, Kimes, Patrick, Knijnenburg, Theo, Lander, Eric, Lawrence, Michael S., Lechan, Ronald, Lee, Darlene, Leraas, Kristen M., Lerario, Antonio, Lin, Pei, Liu, Jia, LiVolsi, Virginia A., Lolla, Laxmi, Lotan, Yair, Lu, Yiling, Ma, Yussanne, Maison, Nicole, Mallery, David, Mannelli, Massimo, Marquard, Jessica, Marra, Marco A., Matthew, Thomas, Mayo, Michael, Méatchi, Tchao, Meng, Shaowu, Merino, Maria J., Mete, Ozgur, Meyerson, Matthew, Mieczkowski, Piotr A., Mills, Gordon B., Moore, Richard A., Morozova, Olena, Morris, Scott, Mose, Lisle E., Mungall, Andrew J., Naresh, Rashi, Nathanson, Katherine L., Newton, Yulia, Ng, Sam, Ni, Ying, Noble, Michael S., Nwariaku, Fiemu, Pacak, Karel, Parker, Joel S., Paul, Evan, Penny, Robert, Perou, Charles M., Perou, Amy H., Pihl, Todd, Powers, James, Rabaglia, Jennifer, Radenbaugh, Amie, Ramirez, Nilsa C., Rao, Arjun, Riester, Anna, Roach, Jeffrey, Sadeghi, Sara, Saksena, Gordon, Salama, Sofie, Saller, Charles, Sandusky, George, Sbiera, Silviu, Schein, Jacqueline E., Schumacher, Steven E., Shelton, Candace, Shelton, Troy, Sheth, Margi, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Simons, Janae V., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi J., Sokolov, Artem, Soloway, Matthew G., Sougnez, Carrie, Stuart, Josh, Sun, Charlie, Swatloski, Teresa, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Tarvin, Katherine, Thiessen, Nina, Thorne, Leigh B., Timmers, Henri J., Tse, Kane, Uzunangelov, Vlado, van Berkel, Anouk, Veluvolu, Umadevi, Vicha, Ales, Voet, Doug, Waldmann, Jens, Wan, Yunhu, Wang, Zhining, Wang, Tracy S., Weaver, Joellen, Weinstein, John N., Weismann, Dirk, Wilkerson, Matthew D., Wise, Lisa, Wong, Tina, Wong, Christopher, Wu, Ye, Yang, Liming, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Jiashan (Julia), Zhang, Wei, Zhu, Jingchun, Zinzindohoué, Franck, Zmuda, Erik, Pathologie Pathologen staf, Onderzoeksgroep 6, Fishbein, Lauren, Leshchiner, Ignaty, Walter, Vonn, Danilova, Ludmila, Robertson, A. Gordon, Johnson, Amy R., Lichtenberg, Tara M., Murray, Bradley A., Ghayee, Hans K., Else, Tobias, Ling, Shiyun, Jefferys, Stuart R., de Cubas, Aguirre A., Wenz, Brandon, Korpershoek, Esther, Amelio, Antonio L., Makowski, Liza, Rathmell, W. Kimryn, Gimenez-Roqueplo, Anne Paule, Giordano, Thomas J., Asa, Sylvia L., Tischler, Arthur S., Akbani, Rehan, Ally, Adrian, Amar, Laurence, Arachchi, Harindra, Auchus, Richard J., Auman, J. Todd, Baertsch, Robert, Balasundaram, Miruna, Balu, Saianand, Bartsch, Detlef K., Baudin, Eric, Bauer, Thomas, Beaver, Allison, Benz, Christopher, Beroukhim, Rameen, Beuschlein, Felix, Bodenheimer, Tom, Boice, Lori, Bowen, Jay, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Carter, Suzie, Cassol, Clarissa A., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cope, Leslie, Crain, Daniel, Curley, Erin, de Krijger, Ronald R., Demchok, John A., Deutschbein, Timo, Dhalla, Noreen, Dimmock, David, Dinjens, Winand N M, Eng, Charis, Eschbacher, Jennifer, Fassnacht, Martin, Felau, Ina, Feldman, Michael, Ferguson, Martin L., Fiddes, Ian, Frazer, Scott, Gabriel, Stacey B., Gardner, Johanna, Gastier-Foster, Julie M., Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Geurts, Jennifer, Goldman, Mary, Graim, Kiley, Gupta, Manaswi, Haan, David, Hahner, Stefanie, Hantel, Constanze, Haussler, David, Hayes, D. Neil, Heiman, David I., Hoadley, Katherine A., Holt, Robert A., Hoyle, Alan P., Huang, Mei, Hunt, Bryan, Hutter, Carolyn M., Jones, Steven J M, Jones, Corbin D., Kasaian, Katayoon, Kebebew, Electron, Kim, Jaegil, Kimes, Patrick, Knijnenburg, Theo, Lander, Eric, Lawrence, Michael S., Lechan, Ronald, Lee, Darlene, Leraas, Kristen M., Lerario, Antonio, Lin, Pei, Liu, Jia, LiVolsi, Virginia A., Lolla, Laxmi, Lotan, Yair, Lu, Yiling, Ma, Yussanne, Maison, Nicole, Mallery, David, Mannelli, Massimo, Marquard, Jessica, Marra, Marco A., Matthew, Thomas, Mayo, Michael, Méatchi, Tchao, Meng, Shaowu, Merino, Maria J., Mete, Ozgur, Meyerson, Matthew, Mieczkowski, Piotr A., Mills, Gordon B., Moore, Richard A., Morozova, Olena, Morris, Scott, Mose, Lisle E., Mungall, Andrew J., Naresh, Rashi, Nathanson, Katherine L., Newton, Yulia, Ng, Sam, Ni, Ying, Noble, Michael S., Nwariaku, Fiemu, Pacak, Karel, Parker, Joel S., Paul, Evan, Penny, Robert, Perou, Charles M., Perou, Amy H., Pihl, Todd, Powers, James, Rabaglia, Jennifer, Radenbaugh, Amie, Ramirez, Nilsa C., Rao, Arjun, Riester, Anna, Roach, Jeffrey, Sadeghi, Sara, Saksena, Gordon, Salama, Sofie, Saller, Charles, Sandusky, George, Sbiera, Silviu, Schein, Jacqueline E., Schumacher, Steven E., Shelton, Candace, Shelton, Troy, Sheth, Margi, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Simons, Janae V., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi J., Sokolov, Artem, Soloway, Matthew G., Sougnez, Carrie, Stuart, Josh, Sun, Charlie, Swatloski, Teresa, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Tarvin, Katherine, Thiessen, Nina, Thorne, Leigh B., Timmers, Henri J., Tse, Kane, Uzunangelov, Vlado, van Berkel, Anouk, Veluvolu, Umadevi, Vicha, Ales, Voet, Doug, Waldmann, Jens, Wan, Yunhu, Wang, Zhining, Wang, Tracy S., Weaver, Joellen, Weinstein, John N., Weismann, Dirk, Wilkerson, Matthew D., Wise, Lisa, Wong, Tina, Wong, Christopher, Wu, Ye, Yang, Liming, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Jiashan (Julia), Zhang, Wei, Zhu, Jingchun, Zinzindohoué, Franck, and Zmuda, Erik

Published
2017

174. Adrenocortical tumors: an integrated clinical, pathologic, and molecular approach at the University of Michigan

Author

Giordano, Thomas J.

Subjects
Tumors, Genomics, Genomes, Criminal investigation, Universities and colleges -- Michigan, Health, University of Michigan
Abstract

Context.--The University of Michigan Health System has a rich tradition in the study and treatment of endocrine neoplasia. Recently, an integrated clinical and research program focused on primary cancer of the adrenal gland has been developed. Objective.--To discuss the foundation of the University of Michigan Adrenal Cancer Program that consists of 3 components: (1) advancement of excellent clinical care, (2) dissemination of resources and knowledge, and (3) scientific discovery. Data Sources.--Recent programmatic activity includes genome-wide transcriptomic evaluation of human adrenocortical tumors for diagnostic and prognostic evaluation; interrogation of the Wnt signaling pathway in adrenocortical carcinoma, using mouse models and transcriptome profiling; and clinical trials with targeted therapy focused on inhibition of insulin-like growth factor signaling pathway. Conclusions.--This review article presents an overview of this program and its recent activity., The University of Michigan (UM; Ann Arbor) has a rich history in the study and treatment of endocrine neoplasia. As director of the endocrinology division, Jerome Conn, MD, performed seminal [...]

Published
2010

175. The Health Insurace Portability and Accountability Act of 1996 (HIPAA) privacy rule: Implications for clinical research

Author

Nosowsky, Rachel and Giordano, Thomas J.

Subjects
Medical research -- Laws, regulations and rules, Medicine, Experimental -- Laws, regulations and rules, Medical policy -- Interpretation and construction, Government regulation, Health, Health Insurance Portability and Accountability Act of 1996
Abstract

A study was conducted on some of the problems associated with Health Insurance Portability and Accountability Act of 1996 (HIPAA), which had a significant adverse impact on the conduct of clinical research in the United States. It was seen that the concerns about HIPAA's impact on research are not universal.

Published
2006

176. Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

Author

Ally, Adrian, primary, Balasundaram, Miruna, additional, Carlsen, Rebecca, additional, Chuah, Eric, additional, Clarke, Amanda, additional, Dhalla, Noreen, additional, Holt, Robert A., additional, Jones, Steven J.M., additional, Lee, Darlene, additional, Ma, Yussanne, additional, Marra, Marco A., additional, Mayo, Michael, additional, Moore, Richard A., additional, Mungall, Andrew J., additional, Schein, Jacqueline E., additional, Sipahimalani, Payal, additional, Tam, Angela, additional, Thiessen, Nina, additional, Cheung, Dorothy, additional, Wong, Tina, additional, Brooks, Denise, additional, Robertson, A. Gordon, additional, Bowlby, Reanne, additional, Mungall, Karen, additional, Sadeghi, Sara, additional, Xi, Liu, additional, Covington, Kyle, additional, Shinbrot, Eve, additional, Wheeler, David A., additional, Gibbs, Richard A., additional, Donehower, Lawrence A., additional, Wang, Linghua, additional, Bowen, Jay, additional, Gastier-Foster, Julie M., additional, Gerken, Mark, additional, Helsel, Carmen, additional, Leraas, Kristen M., additional, Lichtenberg, Tara M., additional, Ramirez, Nilsa C., additional, Wise, Lisa, additional, Zmuda, Erik, additional, Gabriel, Stacey B., additional, Meyerson, Matthew, additional, Cibulskis, Carrie, additional, Murray, Bradley A., additional, Shih, Juliann, additional, Beroukhim, Rameen, additional, Cherniack, Andrew D., additional, Schumacher, Steven E., additional, Saksena, Gordon, additional, Pedamallu, Chandra Sekhar, additional, Chin, Lynda, additional, Getz, Gad, additional, Noble, Michael, additional, Zhang, Hailei, additional, Heiman, David, additional, Cho, Juok, additional, Gehlenborg, Nils, additional, Voet, Douglas, additional, Lin, Pei, additional, Frazer, Scott, additional, Defreitas, Timothy, additional, Meier, Sam, additional, Lawrence, Michael, additional, Kim, Jaegil, additional, Creighton, Chad J., additional, Muzny, Donna, additional, Doddapaneni, HarshaVardhan, additional, Hu, Jianhong, additional, Wang, Min, additional, Morton, Donna, additional, Korchina, Viktoriya, additional, Han, Yi, additional, Dinh, Huyen, additional, Lewis, Lora, additional, Bellair, Michelle, additional, Liu, Xiuping, additional, Santibanez, Jireh, additional, Glenn, Robert, additional, Lee, Sandra, additional, Hale, Walker, additional, Parker, Joel S., additional, Wilkerson, Matthew D., additional, Hayes, D. Neil, additional, Reynolds, Sheila M., additional, Shmulevich, Ilya, additional, Zhang, Wei, additional, Liu, Yuexin, additional, Iype, Lisa, additional, Makhlouf, Hala, additional, Torbenson, Michael S., additional, Kakar, Sanjay, additional, Yeh, Matthew M., additional, Jain, Dhanpat, additional, Kleiner, David E., additional, Dhanasekaran, Renumathy, additional, El-Serag, Hashem B., additional, Yim, Sun Young, additional, Weinstein, John N., additional, Mishra, Lopa, additional, Zhang, Jianping, additional, Akbani, Rehan, additional, Ling, Shiyun, additional, Ju, Zhenlin, additional, Su, Xiaoping, additional, Hegde, Apurva M., additional, Mills, Gordon B., additional, Lu, Yiling, additional, Chen, Jian, additional, Lee, Ju-Seog, additional, Sohn, Bo Hwa, additional, Shim, Jae Jun, additional, Tong, Pan, additional, Aburatani, Hiroyuki, additional, Yamamoto, Shogo, additional, Tatsuno, Kenji, additional, Li, Wei, additional, Xia, Zheng, additional, Stransky, Nicolas, additional, Seiser, Eric, additional, Innocenti, Federico, additional, Gao, Jianjiong, additional, Kundra, Ritika, additional, Zhang, Hongxin, additional, Heins, Zachary, additional, Ochoa, Angelica, additional, Sander, Chris, additional, Ladanyi, Marc, additional, Shen, Ronglai, additional, Arora, Arshi, additional, Sanchez-Vega, Francisco, additional, Schultz, Nikolaus, additional, Kasaian, Katayoon, additional, Radenbaugh, Amie, additional, Bissig, Karl-Dimiter, additional, Moore, David D., additional, Totoki, Yasushi, additional, Nakamura, Hiromi, additional, Shibata, Tatsuhiro, additional, Yau, Christina, additional, Graim, Kiley, additional, Stuart, Josh, additional, Haussler, David, additional, Slagle, Betty L., additional, Ojesina, Akinyemi I., additional, Katsonis, Panagiotis, additional, Koire, Amanda, additional, Lichtarge, Olivier, additional, Hsu, Teng-Kuei, additional, Ferguson, Martin L., additional, Demchok, John A., additional, Felau, Ina, additional, Sheth, Margi, additional, Tarnuzzer, Roy, additional, Wang, Zhining, additional, Yang, Liming, additional, Zenklusen, Jean C., additional, Zhang, Jiashan, additional, Hutter, Carolyn M., additional, Sofia, Heidi J., additional, Verhaak, Roel G.W., additional, Zheng, Siyuan, additional, Lang, Frederick, additional, Chudamani, Sudha, additional, Liu, Jia, additional, Lolla, Laxmi, additional, Wu, Ye, additional, Naresh, Rashi, additional, Pihl, Todd, additional, Sun, Charlie, additional, Wan, Yunhu, additional, Benz, Christopher, additional, Perou, Amy H., additional, Thorne, Leigh B., additional, Boice, Lori, additional, Huang, Mei, additional, Rathmell, W. Kimryn, additional, Noushmehr, Houtan, additional, Saggioro, Fabiano Pinto, additional, Tirapelli, Daniela Pretti da Cunha, additional, Junior, Carlos Gilberto Carlotti, additional, Mente, Enio David, additional, Silva, Orlando de Castro, additional, Trevisan, Felipe Amstalden, additional, Kang, Koo Jeong, additional, Ahn, Keun Soo, additional, Giama, Nasra H., additional, Moser, Catherine D., additional, Giordano, Thomas J., additional, Vinco, Michelle, additional, Welling, Theodore H., additional, Crain, Daniel, additional, Curley, Erin, additional, Gardner, Johanna, additional, Mallery, David, additional, Morris, Scott, additional, Paulauskis, Joseph, additional, Penny, Robert, additional, Shelton, Candace, additional, Shelton, Troy, additional, Kelley, Robin, additional, Park, Joong-Won, additional, Chandan, Vishal S., additional, Roberts, Lewis R., additional, Bathe, Oliver F., additional, Hagedorn, Curt H., additional, Auman, J. Todd, additional, O'Brien, Daniel R., additional, Kocher, Jean-Pierre A., additional, Jones, Corbin D., additional, Mieczkowski, Piotr A., additional, Perou, Charles M., additional, Skelly, Tara, additional, Tan, Donghui, additional, Veluvolu, Umadevi, additional, Balu, Saianand, additional, Bodenheimer, Tom, additional, Hoyle, Alan P., additional, Jefferys, Stuart R., additional, Meng, Shaowu, additional, Mose, Lisle E., additional, Shi, Yan, additional, Simons, Janae V., additional, Soloway, Matthew G., additional, Roach, Jeffrey, additional, Hoadley, Katherine A., additional, Baylin, Stephen B., additional, Shen, Hui, additional, Hinoue, Toshinori, additional, Bootwalla, Moiz S., additional, Van Den Berg, David J., additional, Weisenberger, Daniel J., additional, Lai, Phillip H., additional, Holbrook, Andrea, additional, Berrios, Mario, additional, and Laird, Peter W., additional

Published
2017
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178. An international Ki67 reproducibility study in adrenal cortical Carcinoma

Author

Papathomas, Thomas G., Pucci, Eugenio, Giordano, Thomas J., Lu, Hao, Duregon, Eleonora, Volante, Marco, Papotti, Mauro, Lloyd, Ricardo V., Tischler, Arthur S., Van Nederveen, Francien H., Nose, Vania, Erickson, Lori, Mete, Ozgur, Asa, Sylvia L., Turchini, John, Gill, Anthony J., Matias-Guiu, Xavier, Skordilis, Kassiani, Stephenson, Timothy J., Tissier, Frederique, Feelders, Richard A., Smid, Marcel, Nigg, Alex, Korpershoek, Esther, Van Der Spek, Peter J., Dinjens, Winand N M, Stubbs, Andrew P., De Krijger, Ronald R., Papathomas, Thomas G., Pucci, Eugenio, Giordano, Thomas J., Lu, Hao, Duregon, Eleonora, Volante, Marco, Papotti, Mauro, Lloyd, Ricardo V., Tischler, Arthur S., Van Nederveen, Francien H., Nose, Vania, Erickson, Lori, Mete, Ozgur, Asa, Sylvia L., Turchini, John, Gill, Anthony J., Matias-Guiu, Xavier, Skordilis, Kassiani, Stephenson, Timothy J., Tissier, Frederique, Feelders, Richard A., Smid, Marcel, Nigg, Alex, Korpershoek, Esther, Van Der Spek, Peter J., Dinjens, Winand N M, Stubbs, Andrew P., and De Krijger, Ronald R.

Published
2016

179. Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma: A Paradigm Shift to Reduce Overtreatment of Indolent Tumors.

Author

Nikiforov, Yuri E, Nikiforov, Yuri E, Seethala, Raja R, Tallini, Giovanni, Baloch, Zubair W, Basolo, Fulvio, Thompson, Lester DR, Barletta, Justine A, Wenig, Bruce M, Al Ghuzlan, Abir, Kakudo, Kennichi, Giordano, Thomas J, Alves, Venancio A, Khanafshar, Elham, Asa, Sylvia L, El-Naggar, Adel K, Gooding, William E, Hodak, Steven P, Lloyd, Ricardo V, Maytal, Guy, Mete, Ozgur, Nikiforova, Marina N, Nosé, Vania, Papotti, Mauro, Poller, David N, Sadow, Peter M, Tischler, Arthur S, Tuttle, R Michael, Wall, Kathryn B, LiVolsi, Virginia A, Randolph, Gregory W, Ghossein, Ronald A, Nikiforov, Yuri E, Nikiforov, Yuri E, Seethala, Raja R, Tallini, Giovanni, Baloch, Zubair W, Basolo, Fulvio, Thompson, Lester DR, Barletta, Justine A, Wenig, Bruce M, Al Ghuzlan, Abir, Kakudo, Kennichi, Giordano, Thomas J, Alves, Venancio A, Khanafshar, Elham, Asa, Sylvia L, El-Naggar, Adel K, Gooding, William E, Hodak, Steven P, Lloyd, Ricardo V, Maytal, Guy, Mete, Ozgur, Nikiforova, Marina N, Nosé, Vania, Papotti, Mauro, Poller, David N, Sadow, Peter M, Tischler, Arthur S, Tuttle, R Michael, Wall, Kathryn B, LiVolsi, Virginia A, Randolph, Gregory W, and Ghossein, Ronald A

Abstract

ImportanceAlthough growing evidence points to highly indolent behavior of encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC), most patients with EFVPTC are treated as having conventional thyroid cancer.ObjectiveTo evaluate clinical outcomes, refine diagnostic criteria, and develop a nomenclature that appropriately reflects the biological and clinical characteristics of EFVPTC.Design, setting, and participantsInternational, multidisciplinary, retrospective study of patients with thyroid nodules diagnosed as EFVPTC, including 109 patients with noninvasive EFVPTC observed for 10 to 26 years and 101 patients with invasive EFVPTC observed for 1 to 18 years. Review of digitized histologic slides collected at 13 sites in 5 countries by 24 thyroid pathologists from 7 countries. A series of teleconferences and a face-to-face conference were used to establish consensus diagnostic criteria and develop new nomenclature.Main outcomes and measuresFrequency of adverse outcomes, including death from disease, distant or locoregional metastases, and structural or biochemical recurrence, in patients with noninvasive and invasive EFVPTC diagnosed on the basis of a set of reproducible histopathologic criteria.ResultsConsensus diagnostic criteria for EFVPTC were developed by 24 thyroid pathologists. All of the 109 patients with noninvasive EFVPTC (67 treated with only lobectomy, none received radioactive iodine ablation) were alive with no evidence of disease at final follow-up (median [range], 13 [10-26] years). An adverse event was seen in 12 of 101 (12%) of the cases of invasive EFVPTC, including 5 patients developing distant metastases, 2 of whom died of disease. Based on the outcome information for noninvasive EFVPTC, the name "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) was adopted. A simplified diagnostic nuclear scoring scheme was developed and validated, yielding a sensitivity of 98.6% (95% CI, 96.3%-99.4%), specific

Published
2016

180. Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma.

Author

Zheng, Siyuan, Zheng, Siyuan, Cherniack, Andrew D, Dewal, Ninad, Moffitt, Richard A, Danilova, Ludmila, Murray, Bradley A, Lerario, Antonio M, Else, Tobias, Knijnenburg, Theo A, Ciriello, Giovanni, Kim, Seungchan, Assie, Guillaume, Morozova, Olena, Akbani, Rehan, Shih, Juliann, Hoadley, Katherine A, Choueiri, Toni K, Waldmann, Jens, Mete, Ozgur, Robertson, A Gordon, Wu, Hsin-Ta, Raphael, Benjamin J, Shao, Lina, Meyerson, Matthew, Demeure, Michael J, Beuschlein, Felix, Gill, Anthony J, Sidhu, Stan B, Almeida, Madson Q, Fragoso, Maria CBV, Cope, Leslie M, Kebebew, Electron, Habra, Mouhammed A, Whitsett, Timothy G, Bussey, Kimberly J, Rainey, William E, Asa, Sylvia L, Bertherat, Jérôme, Fassnacht, Martin, Wheeler, David A, Cancer Genome Atlas Research Network, Hammer, Gary D, Giordano, Thomas J, Verhaak, Roel GW, Zheng, Siyuan, Zheng, Siyuan, Cherniack, Andrew D, Dewal, Ninad, Moffitt, Richard A, Danilova, Ludmila, Murray, Bradley A, Lerario, Antonio M, Else, Tobias, Knijnenburg, Theo A, Ciriello, Giovanni, Kim, Seungchan, Assie, Guillaume, Morozova, Olena, Akbani, Rehan, Shih, Juliann, Hoadley, Katherine A, Choueiri, Toni K, Waldmann, Jens, Mete, Ozgur, Robertson, A Gordon, Wu, Hsin-Ta, Raphael, Benjamin J, Shao, Lina, Meyerson, Matthew, Demeure, Michael J, Beuschlein, Felix, Gill, Anthony J, Sidhu, Stan B, Almeida, Madson Q, Fragoso, Maria CBV, Cope, Leslie M, Kebebew, Electron, Habra, Mouhammed A, Whitsett, Timothy G, Bussey, Kimberly J, Rainey, William E, Asa, Sylvia L, Bertherat, Jérôme, Fassnacht, Martin, Wheeler, David A, Cancer Genome Atlas Research Network, Hammer, Gary D, Giordano, Thomas J, and Verhaak, Roel GW

Abstract

We describe a comprehensive genomic characterization of adrenocortical carcinoma (ACC). Using this dataset, we expand the catalogue of known ACC driver genes to include PRKAR1A, RPL22, TERF2, CCNE1, and NF1. Genome wide DNA copy-number analysis revealed frequent occurrence of massive DNA loss followed by whole-genome doubling (WGD), which was associated with aggressive clinical course, suggesting WGD is a hallmark of disease progression. Corroborating this hypothesis were increased TERT expression, decreased telomere length, and activation of cell-cycle programs. Integrated subtype analysis identified three ACC subtypes with distinct clinical outcome and molecular alterations which could be captured by a 68-CpG probe DNA-methylation signature, proposing a strategy for clinical stratification of patients based on molecular markers.

Published
2016

181. An international Ki67 reproducibility study in adrenal cortical Carcinoma

Author

Pathologie patiënten zorg, Papathomas, Thomas G., Pucci, Eugenio, Giordano, Thomas J., Lu, Hao, Duregon, Eleonora, Volante, Marco, Papotti, Mauro, Lloyd, Ricardo V., Tischler, Arthur S., Van Nederveen, Francien H., Nose, Vania, Erickson, Lori, Mete, Ozgur, Asa, Sylvia L., Turchini, John, Gill, Anthony J., Matias-Guiu, Xavier, Skordilis, Kassiani, Stephenson, Timothy J., Tissier, Frederique, Feelders, Richard A., Smid, Marcel, Nigg, Alex, Korpershoek, Esther, Van Der Spek, Peter J., Dinjens, Winand N M, Stubbs, Andrew P., De Krijger, Ronald R., Pathologie patiënten zorg, Papathomas, Thomas G., Pucci, Eugenio, Giordano, Thomas J., Lu, Hao, Duregon, Eleonora, Volante, Marco, Papotti, Mauro, Lloyd, Ricardo V., Tischler, Arthur S., Van Nederveen, Francien H., Nose, Vania, Erickson, Lori, Mete, Ozgur, Asa, Sylvia L., Turchini, John, Gill, Anthony J., Matias-Guiu, Xavier, Skordilis, Kassiani, Stephenson, Timothy J., Tissier, Frederique, Feelders, Richard A., Smid, Marcel, Nigg, Alex, Korpershoek, Esther, Van Der Spek, Peter J., Dinjens, Winand N M, Stubbs, Andrew P., and De Krijger, Ronald R.

Published
2016

182. An immune response manifested by the common occurrence of annexins I and II autoantibodies and high circulating levels of IL-6 in lung cancer

Author

Brichory, Franck M., Misek, David E., Yim, Anne-Marie, Krause, Melissa C., Giordano, Thomas J., Beer, David G., and Hanash, Samir M.

Subjects
Immune response -- Physiological aspects, Autoantibodies -- Physiological aspects, Lung cancer -- Diagnosis, Tumor antigens -- Physiological aspects, Science and technology
Abstract

The identification of circulating tumor antigens or their related autoantibodies provides a means for early cancer diagnosis as well as leads for therapy. The purpose of this study was to identify proteins that commonly induce a humoral response in lung cancer by using a proteomic approach and to investigate biological processes that may be associated with the development of autoantibodies. Aliquots of solubilized proteins from a lung adenocarcinoma cell line (A549) and from lung tumors were subjected to two-dimensional PAGE, followed by Western blot analysis in which individual sera were tested for primary antibodies. Sera from 54 newly diagnosed patients with lung cancer and 60 patients with other cancers and from 61 noncancer controls were analyzed. Sera from 60% of patients with lung adenocarcinoma and 33% of patients with squamous cell lung carcinoma but none of the noncancer controls exhibited IgG-based reactivity against proteins identified as glycosylated annexins I and/or II. Immunohistochemical analysis showed that annexin I was expressed diffusely in neoplastic cells in lung tumor tissues, whereas annexin II was predominant at the cell surface. Interestingly, IL-6 levels were significantly higher in sera of antibody-positive lung cancer patients compared with antibody-negative patients and controls. We conclude that an immune response manifested by annexins I and II autoantibodies occurs commonly in lung cancer and is associated with high circulating levels of an inflammatory cytokine. The proteomic approach we have implemented has utility for the development of serum-based assays for cancer diagnosis as we report in this paper on the discovery of antiannexins I and/or II in sera from patients with lung cancer.

Published
2001

183. Genetic variants in thyroid cancer distant metastases

Author

Justiniano, Steven E, primary, McElroy, Joseph P, additional, Yu, Lianbo, additional, Yilmaz, Ayse Selen, additional, Coombes, Kevin R, additional, Senter, Leigha, additional, Nagy, Rebecca, additional, Wakely, Paul, additional, Volinia, Stefano, additional, Vinco, Michelle, additional, Giordano, Thomas J, additional, Croce, Carlo M, additional, Saji, Motoyasu, additional, and Ringel, Matthew D, additional

Published
2016
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186. Nomenclature Revision for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma

Author

Nikiforov, Yuri E., primary, Seethala, Raja R., additional, Tallini, Giovanni, additional, Baloch, Zubair W., additional, Basolo, Fulvio, additional, Thompson, Lester D. R., additional, Barletta, Justine A., additional, Wenig, Bruce M., additional, Al Ghuzlan, Abir, additional, Kakudo, Kennichi, additional, Giordano, Thomas J., additional, Alves, Venancio A., additional, Khanafshar, Elham, additional, Asa, Sylvia L., additional, El-Naggar, Adel K., additional, Gooding, William E., additional, Hodak, Steven P., additional, Lloyd, Ricardo V., additional, Maytal, Guy, additional, Mete, Ozgur, additional, Nikiforova, Marina N., additional, Nosé, Vania, additional, Papotti, Mauro, additional, Poller, David N., additional, Sadow, Peter M., additional, Tischler, Arthur S., additional, Tuttle, R. Michael, additional, Wall, Kathryn B., additional, LiVolsi, Virginia A., additional, Randolph, Gregory W., additional, and Ghossein, Ronald A., additional

Published
2016
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187. Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

Author

Zheng, Siyuan, primary, Cherniack, Andrew D., additional, Dewal, Ninad, additional, Moffitt, Richard A., additional, Danilova, Ludmila, additional, Murray, Bradley A., additional, Lerario, Antonio M., additional, Else, Tobias, additional, Knijnenburg, Theo A., additional, Ciriello, Giovanni, additional, Kim, Seungchan, additional, Assie, Guillaume, additional, Morozova, Olena, additional, Akbani, Rehan, additional, Shih, Juliann, additional, Hoadley, Katherine A., additional, Choueiri, Toni K., additional, Waldmann, Jens, additional, Mete, Ozgur, additional, Robertson, A. Gordon, additional, Wu, Hsin-Ta, additional, Raphael, Benjamin J., additional, Shao, Lina, additional, Meyerson, Matthew, additional, Demeure, Michael J., additional, Beuschlein, Felix, additional, Gill, Anthony J., additional, Sidhu, Stan B., additional, Almeida, Madson Q., additional, Fragoso, Maria C.B.V., additional, Cope, Leslie M., additional, Kebebew, Electron, additional, Habra, Mouhammed A., additional, Whitsett, Timothy G., additional, Bussey, Kimberly J., additional, Rainey, William E., additional, Asa, Sylvia L., additional, Bertherat, Jérôme, additional, Fassnacht, Martin, additional, Wheeler, David A., additional, Hammer, Gary D., additional, Giordano, Thomas J., additional, Verhaak, Roel G.W., additional, Zheng, Siyuan, additional, Assié, Guillaume, additional, Wu, Hsin-Tu, additional, Almeida, Madson, additional, Barisson Fragoso, Maria Candida, additional, Habra, Mouhammed Amir, additional, Benz, Christopher, additional, Ally, Adrian, additional, Balasundaram, Miruna, additional, Bowlby, Reanne, additional, Brooks, Denise, additional, Butterfield, Yaron S.N., additional, Carlsen, Rebecca, additional, Dhalla, Noreen, additional, Guin, Ranabir, additional, Holt, Robert A., additional, Jones, Steven J.M., additional, Kasaian, Katayoon, additional, Lee, Darlene, additional, Li, Haiyan I., additional, Lim, Lynette, additional, Ma, Yussanne, additional, Marra, Marco A., additional, Mayo, Michael, additional, Moore, Richard A., additional, Mungall, Andrew J., additional, Mungall, Karen, additional, Sadeghi, Sara, additional, Schein, Jacqueline E., additional, Sipahimalani, Payal, additional, Tam, Angela, additional, Thiessen, Nina, additional, Park, Peter J., additional, Kroiss, Matthias, additional, Gao, Jianjiong, additional, Sander, Chris, additional, Schultz, Nikolaus, additional, Jones, Corbin D., additional, Kucherlapati, Raju, additional, Mieczkowski, Piotr A., additional, Parker, Joel S., additional, Perou, Charles M., additional, Tan, Donghui, additional, Veluvolu, Umadevi, additional, Wilkerson, Matthew D., additional, Hayes, D. Neil, additional, Ladanyi, Marc, additional, Quinkler, Marcus, additional, Auman, J. Todd, additional, Latronico, Ana Claudia, additional, Mendonca, Berenice B., additional, Sibony, Mathilde, additional, Sanborn, Zack, additional, Bellair, Michelle, additional, Buhay, Christian, additional, Covington, Kyle, additional, Dahdouli, Mahmoud, additional, Dinh, Huyen, additional, Doddapaneni, Harsha, additional, Downs, Brittany, additional, Drummond, Jennifer, additional, Gibbs, Richard, additional, Hale, Walker, additional, Han, Yi, additional, Hawes, Alicia, additional, Hu, Jianhong, additional, Kakkar, Nipun, additional, Kalra, Divya, additional, Khan, Ziad, additional, Kovar, Christine, additional, Lee, Sandy, additional, Lewis, Lora, additional, Morgan, Margaret, additional, Morton, Donna, additional, Muzny, Donna, additional, Santibanez, Jireh, additional, Xi, Liu, additional, Dousset, Bertrand, additional, Groussin, Lionel, additional, Libé, Rossella, additional, Chin, Lynda, additional, Reynolds, Sheila, additional, Shmulevich, Ilya, additional, Chudamani, Sudha, additional, Liu, Jia, additional, Lolla, Laxmi, additional, Wu, Ye, additional, Yeh, Jen Jen, additional, Balu, Saianand, additional, Bodenheimer, Tom, additional, Hoyle, Alan P., additional, Jefferys, Stuart R., additional, Meng, Shaowu, additional, Mose, Lisle E., additional, Shi, Yan, additional, Simons, Janae V., additional, Soloway, Matthew G., additional, Wu, Junyuan, additional, Zhang, Wei, additional, Mills Shaw, Kenna R., additional, Demchok, John A., additional, Felau, Ina, additional, Sheth, Margi, additional, Tarnuzzer, Roy, additional, Wang, Zhining, additional, Yang, Liming, additional, Zenklusen, Jean C., additional, Zhang, Jiashan (Julia), additional, Davidsen, Tanja, additional, Crawford, Catherine, additional, Hutter, Carolyn M., additional, Sofia, Heidi J., additional, Roach, Jeffrey, additional, Bshara, Wiam, additional, Gaudioso, Carmelo, additional, Morrison, Carl, additional, Soon, Patsy, additional, Alonso, Shelley, additional, Baboud, Julien, additional, Pihl, Todd, additional, Raman, Rohini, additional, Sun, Qiang, additional, Wan, Yunhu, additional, Naresh, Rashi, additional, Arachchi, Harindra, additional, Beroukhim, Rameen, additional, Carter, Scott L., additional, Cho, Juok, additional, Frazer, Scott, additional, Gabriel, Stacey B., additional, Getz, Gad, additional, Heiman, David I., additional, Kim, Jaegil, additional, Lawrence, Michael S., additional, Lin, Pei, additional, Noble, Michael S., additional, Saksena, Gordon, additional, Schumacher, Steven E., additional, Sougnez, Carrie, additional, Voet, Doug, additional, Zhang, Hailei, additional, Bowen, Jay, additional, Coppens, Sara, additional, Gastier-Foster, Julie M., additional, Gerken, Mark, additional, Helsel, Carmen, additional, Leraas, Kristen M., additional, Lichtenberg, Tara M., additional, Ramirez, Nilsa C., additional, Wise, Lisa, additional, Zmuda, Erik, additional, Baylin, Stephen, additional, Herman, James G., additional, LoBello, Janine, additional, Watanabe, Aprill, additional, Haussler, David, additional, Radenbaugh, Amie, additional, Rao, Arjun, additional, Zhu, Jingchun, additional, Bartsch, Detlef K., additional, Sbiera, Silviu, additional, Allolio, Bruno, additional, Deutschbein, Timo, additional, Ronchi, Cristina, additional, Raymond, Victoria M., additional, Vinco, Michelle, additional, Amble, Linda, additional, Bootwalla, Moiz S., additional, Lai, Phillip H., additional, Van Den Berg, David J., additional, Weisenberger, Daniel J., additional, Robinson, Bruce, additional, Ju, Zhenlin, additional, Kim, Hoon, additional, Ling, Shiyun, additional, Liu, Wenbin, additional, Lu, Yiling, additional, Mills, Gordon B., additional, Sircar, Kanishka, additional, Wang, Qianghu, additional, Yoshihara, Kosuke, additional, Laird, Peter W., additional, Fan, Yu, additional, Wang, Wenyi, additional, Shinbrot, Eve, additional, Reincke, Martin, additional, Weinstein, John N., additional, Meier, Sam, additional, and Defreitas, Timothy, additional

Published
2016
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188. EZH2 is overexpressed in adrenocortical carcinoma and is associated with disease progression

Author

Drelon, Coralie, primary, Berthon, Annabel, additional, Mathieu, Mickael, additional, Ragazzon, Bruno, additional, Kuick, Rork, additional, Tabbal, Houda, additional, Septier, Amandine, additional, Rodriguez, Stéphanie, additional, Batisse-Lignier, Marie, additional, Sahut-Barnola, Isabelle, additional, Dumontet, Typhanie, additional, Pointud, Jean-Christophe, additional, Lefrançois-Martinez, Anne-Marie, additional, Baron, Silvère, additional, Giordano, Thomas J., additional, Bertherat, Jérôme, additional, Martinez, Antoine, additional, and Val, Pierre, additional

Published
2016
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190. An International Ki67 Reproducibility Study in Adrenal Cortical Carcinoma

Author

Papathomas, Thomas G., primary, Pucci, Eugenio, additional, Giordano, Thomas J., additional, Lu, Hao, additional, Duregon, Eleonora, additional, Volante, Marco, additional, Papotti, Mauro, additional, Lloyd, Ricardo V., additional, Tischler, Arthur S., additional, van Nederveen, Francien H., additional, Nose, Vania, additional, Erickson, Lori, additional, Mete, Ozgur, additional, Asa, Sylvia L., additional, Turchini, John, additional, Gill, Anthony J., additional, Matias-Guiu, Xavier, additional, Skordilis, Kassiani, additional, Stephenson, Timothy J., additional, Tissier, Frédérique, additional, Feelders, Richard A., additional, Smid, Marcel, additional, Nigg, Alex, additional, Korpershoek, Esther, additional, van der Spek, Peter J., additional, Dinjens, Winand N.M., additional, Stubbs, Andrew P., additional, and de Krijger, Ronald R., additional

Published
2016
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191. Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers

Author

Aragon Han, Patricia, primary, Kim, Hyun-seok, additional, Cho, Soonweng, additional, Fazeli, Roghayeh, additional, Najafian, Alireza, additional, Khawaja, Hunain, additional, McAlexander, Melissa, additional, Dy, Benzon, additional, Sorensen, Meredith, additional, Aronova, Anna, additional, Sebo, Thomas J., additional, Giordano, Thomas J., additional, Fahey, Thomas J., additional, Thompson, Geoffrey B., additional, Gauger, Paul G., additional, Somervell, Helina, additional, Bishop, Justin A., additional, Eshleman, James R., additional, Schneider, Eric B., additional, Witwer, Kenneth W., additional, Umbricht, Christopher B., additional, and Zeiger, Martha A., additional

Published
2016
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192. Molecular Heterogeneity in Aldosterone-Producing Adenomas

Author

Nanba, Kazutaka, primary, Chen, Andrew X., additional, Omata, Kei, additional, Vinco, Michelle, additional, Giordano, Thomas J., additional, Else, Tobias, additional, Hammer, Gary D., additional, Tomlins, Scott A., additional, and Rainey, William E., additional

Published
2016
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195. Immunohistochemical Biomarkers of Adrenal Cortical Neoplasms.

Author

Mete, Ozgur, Asa, Sylvia L., Giordano, Thomas J., Papotti, Mauro, Sasano, Hironobu, and Volante, Marco

Abstract

Careful morphological evaluation forms the basis of the workup of an adrenal cortical neoplasm. However, the adoption of immunohistochemical biomarkers has added tremendous value to enhance diagnostic accuracy. The authors provide a brief review of immunohistochemical biomarkers that have been used in the confirmation of adrenal cortical origin and in the detection of the source of functional adrenal cortical proliferations, as well as diagnostic, predictive, and prognostic biomarkers of adrenal cortical carcinoma. In addition, a brief section on potential novel theranostic biomarkers in the prediction of treatment response to mitotane and other relevant chemotherapeutic agents is also provided. In the era of precision and personalized medical practice, adoption of combined morphology and immunohistochemistry provides a new approach to the diagnostic workup of adrenal cortical neoplasms, reflecting the evolution of clinical responsibility of pathologists. [ABSTRACT FROM AUTHOR]

Published
2018
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196. Discordance between imaging and immunohistochemistry in unilateral primary aldosteronism.

Author

Nanba, Aya T., Nanba, Kazutaka, Byrd, James B., Shields, James J., Giordano, Thomas J., Miller, Barbara S., Rainey, William E., Auchus, Richard J., and Turcu, Adina F.

Subjects
HYPERALDOSTERONISM, IMMUNOHISTOCHEMISTRY, COMPUTED tomography, ADRENALECTOMY, BIOCHEMISTRY
Abstract

Objective Correct subtyping of primary aldosteronism ( PA) is essential for good surgical outcomes. Adrenal vein sampling ( AVS) and/or computed tomography ( CT) are used for PA subclassification. Clinical and/or biochemical improvement after surgery, however, is not always achieved in patients with presumed unilateral PA. We aimed to identify the pitfalls in PA subclassification leading to surgical treatment failures. Patients and Design We retrospectively studied 208 patients who underwent adrenal vein sampling ( AVS) for PA subclassification in a tertiary referral centre, between January 2009 and August 2016. Simultaneous bilateral AVS was performed before and after cosyntropin administration. We implemented immunohistochemistry for aldosterone synthase ( CYP11B2) and 17α-hydroxylase/17,20 lyase ( CYP17A1) in adrenal glands resected from patients without improvement of PA after surgical treatment and from those with limitations in AVS interpretation. Results Of 55 patients who underwent adrenalectomy, three (5.5%) had no improvement of PA. All three patients underwent partial adrenalectomy to remove a CT-detected nodule present on the same side with AVS lateralization. Immunohistochemistry revealed a CYP11B2-negative nodule in both cases available. All patients who underwent total adrenalectomy based on AVS lateralization benefitted from surgery, including three patients with unilateral unsuccessful AVS and aldosterone suppression in the catheterized side vs inferior vena cava. Conclusions Radiographically identified adrenal nodules are not always a source of PA, even when ipsilateral with AVS lateralization. These data caution against reliance on imaging findings, either alone or in conjunction with AVS, to guide surgery for PA. [ABSTRACT FROM AUTHOR]

Published
2017
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197. Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model

Author

Duquette, Mark, primary, Sadow, Peter M., additional, Husain, Amjad, additional, Sims, Jennifer N., additional, Antonello, Zeus A., additional, Fischer, Andrew H., additional, Song, Chen, additional, Castellanos-Rizaldos, Elena, additional, Makrigiorgos, G. Mike, additional, Kurebayashi, Junichi, additional, Nose, Vania, additional, Van Hummelen, Paul, additional, Bronson, Roderick T., additional, Vinco, Michelle, additional, Giordano, Thomas J., additional, Dias-Santagata, Dora, additional, Pandolfi, Pier Paolo, additional, and Nucera, Carmelo, additional

Published
2015
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198. Notch signaling regulates gastric antral LGR 5 stem cell function

Author

Demitrack, Elise S, primary, Gifford, Gail B, additional, Keeley, Theresa M, additional, Carulli, Alexis J, additional, VanDussen, Kelli L, additional, Thomas, Dafydd, additional, Giordano, Thomas J, additional, Liu, Zhenyi, additional, Kopan, Raphael, additional, and Samuelson, Linda C, additional

Published
2015
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199. Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands

Author

Nishimoto, Koshiro, primary, Tomlins, Scott A., additional, Kuick, Rork, additional, Cani, Andi K., additional, Giordano, Thomas J., additional, Hovelson, Daniel H., additional, Liu, Chia-Jen, additional, Sanjanwala, Aalok R., additional, Edwards, Michael A., additional, Gomez-Sanchez, Celso E., additional, Nanba, Kazutaka, additional, and Rainey, William E., additional

Published
2015
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200. Role and regulation of coordinately expressedde novopurine biosynthetic enzymesPPATandPAICSin lung cancer

Author

Goswami, Moloy T., primary, Chen, Guoan, additional, Chakravarthi, Balabhadrapatruni V.S.K., additional, Pathi, Satya S., additional, Anand, Sharath K., additional, Carskadon, Shannon L., additional, Giordano, Thomas J., additional, Chinnaiyan, Arul M., additional, Thomas, Dafydd G., additional, Palanisamy, Nallasivam, additional, Beer, David G., additional, and Varambally, Sooryanarayana, additional

Published
2015
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