Search

Your search keyword '"Gilks C"' showing total 2,177 results
Start Over Author "Gilks C"
2,177 results on '"Gilks C"'

151. Data from Biomarker-Based Ovarian Carcinoma Typing: A Histologic Investigation in the Ovarian Tumor Tissue Analysis Consortium

Author

Köbel, Martin, primary, Kalloger, Steve E., primary, Lee, Sandra, primary, Duggan, Máire A., primary, Kelemen, Linda E., primary, Prentice, Leah, primary, Kalli, Kimberly R., primary, Fridley, Brooke L., primary, Visscher, Daniel W., primary, Keeney, Gary L., primary, Vierkant, Robert A., primary, Cunningham, Julie M., primary, Chow, Christine, primary, Ness, Roberta B., primary, Moysich, Kirsten, primary, Edwards, Robert, primary, Modugno, Francesmary, primary, Bunker, Clareann, primary, Wozniak, Eva L., primary, Benjamin, Elizabeth, primary, Gayther, Simon A., primary, Gentry-Maharaj, Aleksandra, primary, Menon, Usha, primary, Gilks, C. Blake, primary, Huntsman, David G., primary, Ramus, Susan J., primary, and Goode, Ellen L., primary

Published
2023
Full Text
View/download PDF

152. Supplementary Slide 3 from Disruption of the Y-Box Binding Protein-1 Results in Suppression of the Epidermal Growth Factor Receptor and HER-2

Author

Wu, Joyce, primary, Lee, Cathy, primary, Yokom, Daniel, primary, Jiang, Helen, primary, Cheang, Maggie C.U., primary, Yorida, Erika, primary, Turbin, Dmitry, primary, Berquin, Isabelle M., primary, Mertens, Peter R., primary, Iftner, Thomas, primary, Gilks, C. Blake, primary, and Dunn, Sandra E., primary

Published
2023
Full Text
View/download PDF

153. Supplementary Figure 1 from Disruption of the Y-Box Binding Protein-1 Results in Suppression of the Epidermal Growth Factor Receptor and HER-2

Author

Wu, Joyce, primary, Lee, Cathy, primary, Yokom, Daniel, primary, Jiang, Helen, primary, Cheang, Maggie C.U., primary, Yorida, Erika, primary, Turbin, Dmitry, primary, Berquin, Isabelle M., primary, Mertens, Peter R., primary, Iftner, Thomas, primary, Gilks, C. Blake, primary, and Dunn, Sandra E., primary

Published
2023
Full Text
View/download PDF

154. Supplementary Figure 1 from Growth Factor Independence-1 Is Expressed in Primary Human Neuroendocrine Lung Carcinomas and Mediates the Differentiation of Murine Pulmonary Neuroendocrine Cells

Author

Kazanjian, Avedis, primary, Wallis, Deeann, primary, Au, Nicholas, primary, Nigam, Rupesh, primary, Venken, Koen J. T., primary, Cagle, Philip T., primary, Dickey, Burton F., primary, Bellen, Hugo J., primary, Gilks, C. Blake, primary, and Grimes, H. Leighton, primary

Published
2023
Full Text
View/download PDF

155. Supplementary Figure 2 from Growth Factor Independence-1 Is Expressed in Primary Human Neuroendocrine Lung Carcinomas and Mediates the Differentiation of Murine Pulmonary Neuroendocrine Cells

Author

Kazanjian, Avedis, primary, Wallis, Deeann, primary, Au, Nicholas, primary, Nigam, Rupesh, primary, Venken, Koen J. T., primary, Cagle, Philip T., primary, Dickey, Burton F., primary, Bellen, Hugo J., primary, Gilks, C. Blake, primary, and Grimes, H. Leighton, primary

Published
2023
Full Text
View/download PDF

159. CCNE1 and survival of patients with tubo-ovarian high-grade serous carcinoma: An Ovarian Tumor Tissue Analysis consortium study

Author

Kang, Eun-Young, Weir, Ashley, Meagher, Nicola S, Farrington, Kyo, Nelson, Gregg S, Ghatage, Prafull, Lee, Cheng-Han, Riggan, Marjorie J, Bolithon, Adelyn, Popovic, Gordana, Leung, Betty, Tang, Katrina, Lambie, Neil, Millstein, Joshua, Alsop, Jennifer, Anglesio, Michael S, Ataseven, Beyhan, Barlow, Ellen, Beckmann, Matthias W, Berger, Jessica, Bisinotto, Christiani, Bösmüller, Hans, Boros, Jessica, Brand, Alison H, Brooks-Wilson, Angela, Brucker, Sara Y, Carney, Michael E, Casablanca, Yovanni, Cazorla-Jiménez, Alicia, Cohen, Paul A, Conrads, Thomas P, Cook, Linda S, Coulson, Penny, Courtney-Brooks, Madeleine, Cramer, Daniel W, Crowe, Philip, Cunningham, Julie M, Cybulski, Cezary, Darcy, Kathleen M, El-Bahrawy, Mona A, Elishaev, Esther, Erber, Ramona, Farrell, Rhonda, Fereday, Sian, Fischer, Anna, García, María J, Gayther, Simon A, Gentry-Maharaj, Aleksandra, Gilks, C Blake, AOCS Group, Grube, Marcel, Harnett, Paul R, Harrington, Shariska Petersen, Harter, Philipp, Hartmann, Arndt, Hecht, Jonathan L, Heikaus, Sebastian, Hein, Alexander, Heitz, Florian, Hendley, Joy, Hernandez, Brenda Y, Polo, Susanna Hernando, Heublein, Sabine, Hirasawa, Akira, Høgdall, Estrid, Høgdall, Claus K, Horlings, Hugo M, Huntsman, David G, Huzarski, Tomasz, Jewell, Andrea, Jimenez-Linan, Mercedes, Jones, Michael E, Kaufmann, Scott H, Kennedy, Catherine J, Khabele, Dineo, Kommoss, Felix KF, Kruitwagen, Roy FPM, Lambrechts, Diether, Le, Nhu D, Lener, Marcin, Lester, Jenny, Leung, Yee, Linder, Anna, Loverix, Liselore, Lubiński, Jan, Madan, Rashna, Maxwell, G Larry, Modugno, Francesmary, Neuhausen, Susan L, Olawaiye, Alexander, Olbrecht, Siel, Orsulic, Sandra, Palacios, José, Pearce, Celeste Leigh, Pike, Malcolm C, Quinn, Carmel M, Mohan, Ganendra Raj, Rodríguez-Antona, Cristina, Ruebner, Matthias, Ryan, Andy, Salfinger, Stuart G, Sasamoto, Naoko, Schildkraut, Joellen M, Schoemaker, Minouk J, Shah, Mitul, Sharma, Raghwa, Shvetsov, Yurii B, Singh, Naveena, Sonke, Gabe S, Steele, Linda, Stewart, Colin, Sundfeldt, Karin, Swerdlow, Anthony J, Talhouk, Aline, Tan, Adeline, Taylor, Sarah E, Terry, Kathryn L, Tołoczko, Aleksandra, Traficante, Nadia, Van De Vijver, Koen K, Van Der Aa, Maaike A, Van Gorp, Toon, Van Nieuwenhuysen, Els, Van-Wagensveld, Lilian, Vergote, Ignace, Vierkant, Robert A, Wang, Chen, Wilkens, Lynne R, Winham, Stacey J, Wu, Anna H, Benitez, Javier, Berchuck, Andrew, Candido Dos Reis, Francisco J, DeFazio, Anna, Fasching, Peter A, Goode, Ellen L, Goodman, Marc T, Gronwald, Jacek, Karlan, Beth Y, Kommoss, Stefan, Menon, Usha, Sinn, Hans-Peter, Staebler, Annette, Brenton, James D, Bowtell, David D, Pharoah, Paul DP, Ramus, Susan J, Köbel, Martin, Meagher, Nicola S [0000-0001-9134-2118], Lee, Cheng-Han [0000-0003-2094-1222], Fereday, Sian [0000-0002-8559-8579], Kennedy, Catherine J [0000-0002-4465-5784], Sasamoto, Naoko [0000-0002-4526-2181], Schildkraut, Joellen M [0000-0002-0990-9339], Talhouk, Aline [0000-0001-7760-410X], Vergote, Ignace [0000-0002-7589-8981], Köbel, Martin [0000-0002-6615-2037], and Apollo - University of Cambridge Repository

Subjects
Ovarian Neoplasms, Oncogene Proteins, Carcinoma, Cystadenocarcinoma, Serous, ovarian cancer, high-grade serous carcinoma, Cyclin E, Humans, Female, prognosis, RNA, Messenger, CCNE1 amplification, cyclin E1 expression, Transcription Factors
Abstract

BACKGROUND: Cyclin E1 (CCNE1) is a potential predictive marker and therapeutic target in tubo-ovarian high-grade serous carcinoma (HGSC). Smaller studies have revealed unfavorable associations for CCNE1 amplification and CCNE1 overexpression with survival, but to date no large-scale, histotype-specific validation has been performed. The hypothesis was that high-level amplification of CCNE1 and CCNE1 overexpression, as well as a combination of the two, are linked to shorter overall survival in HGSC. METHODS: Within the Ovarian Tumor Tissue Analysis consortium, amplification status and protein level in 3029 HGSC cases and mRNA expression in 2419 samples were investigated. RESULTS: High-level amplification (>8 copies by chromogenic in situ hybridization) was found in 8.6% of HGSC and overexpression (>60% with at least 5% demonstrating strong intensity by immunohistochemistry) was found in 22.4%. CCNE1 high-level amplification and overexpression both were linked to shorter overall survival in multivariate survival analysis adjusted for age and stage, with hazard stratification by study (hazard ratio [HR], 1.26; 95% CI, 1.08-1.47, p = .034, and HR, 1.18; 95% CI, 1.05-1.32, p = .015, respectively). This was also true for cases with combined high-level amplification/overexpression (HR, 1.26; 95% CI, 1.09-1.47, p = .033). CCNE1 mRNA expression was not associated with overall survival (HR, 1.00 per 1-SD increase; 95% CI, 0.94-1.06; p = .58). CCNE1 high-level amplification is mutually exclusive with the presence of germline BRCA1/2 pathogenic variants and shows an inverse association to RB1 loss. CONCLUSION: This study provides large-scale validation that CCNE1 high-level amplification is associated with shorter survival, supporting its utility as a prognostic biomarker in HGSC.

Published
2023
Full Text
View/download PDF

162. Reply to Comment on HPV-independent, p53-Wild-type Vulvar Intraepithelial Neoplasia: A Review of Nomenclature and the Journey to Characterize Acanthotic Precursor Lesions of the Vulva

Author

Parra-Herran, Carlos, primary, Nucci, Marisa R., additional, Singh, Naveena, additional, Rakislova, Natalia, additional, Howitt, Brooke E., additional, Hoang, Lynn, additional, Gilks, C. Blake, additional, Bosse, Tjalling, additional, and Watkins, Jaclyn C., additional

Published
2023
Full Text
View/download PDF

164. Well-differentiated Sertoli-Leydig Cell Tumors (SLCTs) Are Not Associated With DICER1 Pathogenic Variants and Represent a Different Tumor Type to Moderately and Poorly Differentiated SLCTs

Author

McCluggage, W. Glenn, primary, Rivera, Barbara, additional, Chong, Anne-Sophie, additional, Clarke, Blaise A., additional, Schultz, Kris Ann P., additional, Dehner, Louis P., additional, Tchrakian, Nairi, additional, Apellaniz-Ruiz, Maria, additional, Gilks, C. Blake, additional, Kommoss, Friedrich, additional, Stewart, Colin J.R., additional, and Foulkes, William D., additional

Published
2022
Full Text
View/download PDF

169. High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations

Author

Murali, Rajmohan, Davidson, Ben, Fadare, Oluwole, Carlson, Joseph A., Crum, Christopher P., Gilks, C. Blake, Irving, Julie A., Malpica, Anais, Matias-Guiu, Xavier, McCluggage, W. Glenn, Mittal, Khush, Oliva, Esther, Parkash, Vinita, Rutgers, Joanne K. L., Staats, Paul N., Stewart, Colin J. R., Tornos, Carmen, and Soslow, Robert A.

Published
2019
Full Text
View/download PDF

175. Corrigendum to “Low-grade serous carcinoma (LGSC): A Canadian multicenter review of practice patterns and patient outcomes” [Gynecologic Oncology, Volume 157, Issue 1, April 2020, Pages 36–45]

Author

Scott, Stephanie A., primary, Fernandez, Marta Llaurado, additional, Kim, Hannah, additional, Elit, Laurie, additional, Nourmoussavi, Melica, additional, Glaze, Sarah, additional, Roberts, Lesley, additional, Offman, Saul L., additional, Rahimi, Kurosh, additional, Lytwyn, Alice, additional, Sur, Monalisa, additional, Gilks, C. Blake, additional, Matheson, Kara, additional, Köbel, Martin, additional, Dawson, Amy, additional, Tinker, Anna V., additional, Kwon, Janice S., additional, Hoskins, Paul, additional, Santos, Jennifer L., additional, Cheung, Andrea, additional, Provencher, Diane, additional, and Carey, Mark S., additional

Published
2022
Full Text
View/download PDF

176. Data Set for the Reporting of Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma: Recommendations From the International Collaboration on Cancer Reporting (ICCR)

Author

Gilks, C. Blake, primary, Selinger, Christina I., additional, Davidson, Ben, additional, Köbel, Martin, additional, Ledermann, Jonathan A., additional, Lim, Diana, additional, Malpica, Anais, additional, Mikami, Yoshiki, additional, Singh, Naveena, additional, Srinivasan, Radhika, additional, Vang, Russell, additional, Lax, Sigurd F., additional, and McCluggage, W. Glenn, additional

Published
2022
Full Text
View/download PDF

177. Data Set for the Reporting of Carcinomas of the Vulva: Recommendations From the International Collaboration on Cancer Reporting (ICCR)

Author

Hoang, Lynn, primary, Webster, Fleur, additional, Bosse, Tjalling, additional, Focchi, Gustavo, additional, Gilks, C. Blake, additional, Howitt, Brooke E., additional, McAlpine, Jessica N., additional, Ordi, Jaume, additional, Singh, Naveena, additional, Wong, Richard Wing-Cheuk, additional, Lax, Sigurd F., additional, and McCluggage, W. Glenn, additional

Published
2022
Full Text
View/download PDF

179. Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study

Author

Sieh, Weiva, Köbel, Martin, Longacre, Teri A, Bowtell, David D, deFazio, Anna, Goodman, Marc T, Høgdall, Estrid, Deen, Suha, Wentzensen, Nicolas, Moysich, Kirsten B, Brenton, James D, Clarke, Blaise A, Menon, Usha, Gilks, C Blake, Kim, Andre, Madore, Jason, Fereday, Sian, George, Joshy, Galletta, Laura, Lurie, Galina, Wilkens, Lynne R, Carney, Michael E, Thompson, Pamela J, Matsuno, Rayna K, Kjær, Susanne Krüger, Jensen, Allan, Høgdall, Claus, Kalli, Kimberly R, Fridley, Brooke L, Keeney, Gary L, Vierkant, Robert A, Cunningham, Julie M, Brinton, Louise A, Yang, Hannah P, Sherman, Mark E, García-Closas, Montserrat, Lissowska, Jolanta, Odunsi, Kunle, Morrison, Carl, Lele, Shashikant, Bshara, Wiam, Sucheston, Lara, Jimenez-Linan, Mercedes, Driver, Kristy, Alsop, Jennifer, Mack, Marie, McGuire, Valerie, Rothstein, Joseph H, Rosen, Barry P, Bernardini, Marcus Q, Mackay, Helen, Oza, Amit, Wozniak, Eva L, Benjamin, Elizabeth, Gentry-Maharaj, Aleksandra, Gayther, Simon A, Tinker, Anna V, Prentice, Leah M, Chow, Christine, Anglesio, Michael S, Johnatty, Sharon E, Chenevix-Trench, Georgia, Whittemore, Alice S, Pharoah, Paul DP, Goode, Ellen L, Huntsman, David G, and Ramus, Susan J

Published
2013
Full Text
View/download PDF

191. Evolution of Quality Assurance for Clinical Immunohistochemistry in the Era of Precision Medicine. Part 3: Technical Validation of Immunohistochemistry (IHC) Assays in Clinical IHC Laboratories

Author

Torlakovic, Emina E., Cheung, Carol C., D’Arrigo, Corrado, Dietel, Manfred, Francis, Glenn D., Gilks, C. Blake, Hall, Jacqueline A., Hornick, Jason L., Ibrahim, Merdol, Marchetti, Antonio, Miller, Keith, van Krieken, J. Han, Nielsen, Soren, Swanson, Paul E., Vyberg, Mogens, Zhou, Xiaoge, and Taylor, Clive R.

Published
2017
Full Text
View/download PDF

192. The Chemotherapy Response Score (CRS): Interobserver Reproducibility in a Simple and Prognostically Relevant System for Reporting the Histologic Response to Neoadjuvant Chemotherapy in Tuboovarian High-grade Serous Carcinoma

Author

Said, Ian, Böhm, Steffen, Beasley, Joanne, Ellery, Peter, Faruqi, Asma Z., Ganesan, Raji, Hirschowitz, Lynn, Jeetle, Sharanpal, Leen, Sarah Lam Shang, McCluggage, W. Glenn, McDermott, Jacqueline, Merard, Reena, Millner, Thomas O., Trevisan, Giorgia, Vella, Jo, Gilks, C. Blake, and Singh, Naveena

Published
2017
Full Text
View/download PDF

195. Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance

Author

He, Y, Wu, A C, Harrington, B S, Davies, C M, Wallace, S J, Adams, M N, Palmer, J S, Roche, D K, Hollier, B G, Westbrook, T F, Hamidi, H, Konecny, G E, Winterhoff, B, Chetty, N P, Crandon, A J, Oliveira, N B, Shannon, C M, Tinker, A V, Gilks, C B, Coward, J I, Lumley, J W, Perrin, L C, Armes, J E, and Hooper, J D

Published
2016
Full Text
View/download PDF

197. Consensus based recommendations for the diagnosis of serous tubal intraepithelial carcinoma: an international Delphi study.

Author

Bogaerts, Joep M A, van Bommel, Majke H D, Hermens, Rosella P M G, Steenbeek, Miranda P, de Hullu, Joanne A, van der Laak, Jeroen A W M, Shih, Ie‐Ming, McCluggage, W Glenn, Gilks, C Blake, Carlson, Joseph W, Rabban, Joseph T, Ewing‐Graham, Patricia C, Killeen, Jeffrey L, Lastra, Ricardo, Parkash, Vinita, O'Riain, Ciaran, Staebler, Annette, Vang, Russell, Bulten, Johan, and vd Vijver, Koen K

Subjects
CARCINOMA, LIKERT scale, DIAGNOSIS, PATHOLOGISTS
Abstract

Aim: Reliably diagnosing or safely excluding serous tubal intraepithelial carcinoma (STIC), a precursor lesion of tubo‐ovarian high‐grade serous carcinoma (HGSC), is crucial for individual patient care, for better understanding the oncogenesis of HGSC, and for safely investigating novel strategies to prevent tubo‐ovarian carcinoma. To optimize STIC diagnosis and increase its reproducibility, we set up a three‐round Delphi study. Methods and results: In round 1, an international expert panel of 34 gynecologic pathologists, from 11 countries, was assembled to provide input regarding STIC diagnosis, which was used to develop a set of statements. In round 2, the panel rated their level of agreement with those statements on a 9‐point Likert scale. In round 3, statements without previous consensus were rated again by the panel while anonymously disclosing the responses of the other panel members. Finally, each expert was asked to approve or disapprove the complete set of consensus statements. The panel indicated their level of agreement with 64 statements. A total of 27 statements (42%) reached consensus after three rounds. These statements reflect the entire diagnostic work‐up for pathologists, regarding processing and macroscopy (three statements); microscopy (eight statements); immunohistochemistry (nine statements); interpretation and reporting (four statements); and miscellaneous (three statements). The final set of consensus statements was approved by 85%. Conclusion: This study provides an overview of current clinical practice regarding STIC diagnosis amongst expert gynecopathologists. The experts' consensus statements form the basis for a set of recommendations, which may help towards more consistent STIC diagnosis. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

199. 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma

Author

Lee, Cheng-Han, Ou, Wen-Bin, Mariño-Enriquez, Adrian, Zhu, Meijun, Mayeda, Mark, Wang, Yuexiang, Guo, Xiangqian, Brunner, Alayne L., Amant, Frédéric, French, Christopher A., West, Robert B., McAlpine, Jessica N., Gilks, C. Blake, Yaffe, Michael B., Prentice, Leah M., McPherson, Andrew, Jones, Steven J. M., Marra, Marco A., Shah, Sohrab P., van de Rijn, Matt, Huntsman, David G., Cin, Paola Dal, Debiec-Rychter, Maria, Nucci, Marisa R., and Fletcher, Jonathan A.

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results