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494 results on '"Ghanbari, Hossein"'

151. Comparative study of different polymeric coatings for the next-generation magnesium-based biodegradable stents.

Author

Ahmadi Lakalayeh, Gholamreza, Rahvar, Mostafa, Haririan, Esmaeil, Karimi, Roya, and Ghanbari, Hossein

Subjects
SURGICAL stents -- Design & construction, MEDICAL polymers, BIODEGRADABLE materials, MAGNESIUM alloys, CORROSION resistance
Abstract

Development of next-generation bioabsorbable stents based on magnesium alloys is gaining lots of attention. However, finding an appropriate coating in order to enhance its corrosion resistance along with preserving other requirements is still a challenge. In this study, three FDA-approved polymers, namely poly(lactic acid), polycaprolactone and poly(lactic-co-glycolic acid), have been investigated as potential coatings for magnesium-based stents to enhance their corrosion resistance, biocompatibility and haemocompatibility. Potentiodynamic and electrochemical impedance spectroscopy results demonstrated that PLA and PLGA coating performed better in improving corrosion resistance in comparison with uncoated and other coated samples. Although all coated and bare samples displayed desirable results of haemocompatibility assays, PLA-coated samples showed better outcome in terms of biocompatibility. The results revealed that PLA can be considered as a potential coating material to enhance the main characteristics of magnesium-based bioabsorbable stents. [ABSTRACT FROM AUTHOR]

Published
2018
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152. Efficacy and safety of micro/nanostructured polymeric coatings for drug eluting stents.

Author

Rahvar, Mostafa, Lakalayeh, Gholamreza Ahmadi, Majidi, Reza Faridi, Haririan, Ismaeil, Marouf, Bahereh T., and Ghanbari, Hossein

Subjects
DRUG-eluting stents, MEDICAL polymers, POLYMERIC nanocomposites, PHARMACODYNAMICS, SURFACE texture
Abstract

Objectives Efficacy of a polymeric coating for drug eluting stents (DES) depends on its safety and structural properties. Today, it is well known that factors such as surface texture, morphology and drug release kinetics are among the most critical factors that determines the ultimate destiny and success of DES. Therefore, the ability to design and control these critical properties guarantee the success of DES in the body. Methods In this study, two different micro/nanostructured coatings was prepared using poly(lactic acid) and dexamethasone by electrohydrodynamic atomization (EHDA) and spinning as coating methods. To analyze structural properties of coatings different techniques was used including: X-ray diffraction, scanning electron microscopy and confocal microscopy. Platelet, neutrophil and peripheral blood mononuclear cell adhesion was studied to evaluate safety of coatings. Then, antibacterial properties of coatings were considered. Finally, drug release profile was evaluated for 15 days. Results The results showed that suitable surface properties of micro/nanostructured coatings led to very low platelet, neutrophil, PBMN on the surfaces. Micro/nanostructured coatings showed two drug release kinetics that are applicable for different drug delivery systems. Conclusion Based on the results, EHDA method have great potential as a coating method for DES. [ABSTRACT FROM AUTHOR]

Published
2018
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153. Cardiovascular application of polyhedral oligomeric silsesquioxane nanomaterials: a glimpse into prospective horizons

Author

Seifalian, Alexander and Ghanbari,Hossein

Subjects
International Journal of Nanomedicine
Abstract

Hossein Ghanbari1, Achala de Mel1, Alexander M Seifalian1,21Division of Surgery and Interventional Science, Centre for Nanotechnology and Regenerative Medicine, University College London, London, England, UK; 2Royal Free Hampstead NHS Trust Hospital, London, England, UKAbstract: Revolutionary advances in nanotechnology propose novel materials with superior properties for biomedical application. One of the most promising nanomaterials for biomedical application is polyhedral oligomeric silsesquioxane (POSS), an amazing nanocage consisting of an inner inorganic framework of silicon and oxygen atoms and an outer shell of organic groups. The unique properties of this nanoparticle has led to the development of a wide range of nanostructured copolymers with significantly enhanced properties including improved mechanical, chemical, and physical characteristics. Since POSS nanomaterials are highly biocompatible, biomedical application of POSS nanostructures has been intensely explored. One of the most promising areas of application of POSS nanomaterials is the development of cardiovascular implants. The incorporation of POSS into biocompatible polymers has resulted in advanced nanocomposite materials with improved hemocompatibility, antithrombogenicity, enhanced mechanical and surface properties, calcification resistance, and reduced inflammatory response, which make these materials the material of choice for cardiovascular implants. These highly versatile POSS derivatives have opened new horizons to the field of cardiovascular implant. Currently, application of POSS containing polymers in the development of new generation cardiovascular implants including heart valve prostheses, bypass grafts, and coronary stents is under intensive investigation, with encouraging outcomes.Keywords: cardiovascular implants, nanocomposite, polymer&nbsp

Published
2011

164. Biocompatibility and nanostructured materials: applications in nanomedicine.

Author

Adabi, Mahdi, Naghibzadeh, Majid, Adabi, Mohsen, Zarrinfard, Mohammad Ali, Esnaashari, Seyedeh Sara, Seifalian, Alexander M., Faridi-Majidi, Reza, Tanimowo Aiyelabegan, Hammed, and Ghanbari, Hossein

Subjects
BIOCOMPATIBILITY, NANOSTRUCTURED materials, NANOMEDICINE, BLOOD-brain barrier, IMMUNE response
Abstract

There has been huge interest in applications of nanomaterials in biomedical science, including diagnosis, drug delivery, and development of human organs. Number of these nanomaterials has been already studied in human or at pre-clinical trial. There is a growing concern on potential toxicity and adverse effects of nanomaterials on human health, including lack of standard method of assessment of toxicology of these materials. Our investigation indicated that the bare and small nanoparticle have higher toxicity than modified and bulk materials, respectively. In addition, spherical nanoparticles have less toxicity than rod nanoparticles due to immune response of body. [ABSTRACT FROM AUTHOR]

Published
2017
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166. Differentiation of human endometrial stem cells into endothelial-like cells on gelatin/chitosan/bioglass nanofibrous scaffolds.

Author

Shamosi, Atefeh, Mehrabani, Davood, Azami, Mahmoud, Ebrahimi-Barough, Somayeh, Siavashi, Vahid, Ghanbari, Hossein, Sharifi, Esmaeel, Roozafzoon, Reza, and Ai, Jafar

Subjects
STEM cells, ENDOTHELIAL cells, GELATIN, CHITOSAN, BIOACTIVE glasses, NANOFIBERS
Abstract

The capacity of gelatin/chitosan/bioactive glass nanopowders (GEL/CS/BGNPs) scaffolds was investigated for increasing human endometrial stem cells (hEnSCs) differentiation into the endothelial cells in the presence of angiogenic factors. GEL/CS nanofibrous scaffold with different contents of BGNPs were fabricated and assessed. Expression of endothelial markers (CD31, vascular endothelial cadherin (VE-cadherin), and KDR) in differentiated cells was evaluated. Results showed the diameter of nanofiber increases with decreasing the BG content in GEL/CS scaffolds. Moreover,in vitrostudy indicated that the GEL/CS/BGNPs scaffold with 1.5% BGNPs content provided a suitable three-dimensional structure for endothelial cells differentiation. Thus, the GEL/CS/BGNPs scaffold can be recommended for blood vessels repair. [ABSTRACT FROM AUTHOR]

Published
2017
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170. Cardiovascular application of polyhedral oligomeric silsesquioxane nanomaterials: a glimpse into prospective horizons

Author

Ghanbari,Hossein, de Mel,Achala, Seifalian,Alexander M, Ghanbari,Hossein, de Mel,Achala, and Seifalian,Alexander M

Abstract

Hossein Ghanbari1, Achala de Mel1, Alexander M Seifalian1,21Division of Surgery and Interventional Science, Centre for Nanotechnology and Regenerative Medicine, University College London, London, England, UK; 2Royal Free Hampstead NHS Trust Hospital, London, England, UKAbstract: Revolutionary advances in nanotechnology propose novel materials with superior properties for biomedical application. One of the most promising nanomaterials for biomedical application is polyhedral oligomeric silsesquioxane (POSS), an amazing nanocage consisting of an inner inorganic framework of silicon and oxygen atoms and an outer shell of organic groups. The unique properties of this nanoparticle has led to the development of a wide range of nanostructured copolymers with significantly enhanced properties including improved mechanical, chemical, and physical characteristics. Since POSS nanomaterials are highly biocompatible, biomedical application of POSS nanostructures has been intensely explored. One of the most promising areas of application of POSS nanomaterials is the development of cardiovascular implants. The incorporation of POSS into biocompatible polymers has resulted in advanced nanocomposite materials with improved hemocompatibility, antithrombogenicity, enhanced mechanical and surface properties, calcification resistance, and reduced inflammatory response, which make these materials the material of choice for cardiovascular implants. These highly versatile POSS derivatives have opened new horizons to the field of cardiovascular implant. Currently, application of POSS containing polymers in the development of new generation cardiovascular implants including heart valve prostheses, bypass grafts, and coronary stents is under intensive investigation, with encouraging outcomes.Keywords: cardiovascular implants, nanocomposite, polymer&nbsp

Published
2011

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