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1,513 results on '"Gaulard, Philippe"'

154. Rituximab plus gemcitabine and oxaliplatin (R-GemOx) in refractory/relapsed diffuse large B-cell lymphoma: a real-life study in patients ineligible for autologous stem-cell transplantation

Author

Cazelles, Clarisse, primary, Belhadj, Karim, additional, Vellemans, Hélène, additional, Camus, Vincent, additional, Poullot, Elsa, additional, Gaulard, Philippe, additional, Veresezan, Liana, additional, Itti, Emmanuel, additional, Becker, Stéphanie, additional, Carvalho, Muriel, additional, Dupuis, Jehan, additional, Le Bras, Fabien, additional, Lemonnier, François, additional, Roulin, Louise, additional, El Gnaoui, Taoufik, additional, Jardin, Fabrice, additional, Mounier, Nicolas, additional, Tilly, Hervé, additional, and Haioun, Corinne, additional

Published
2021
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155. [Impact of algorithms proposed by the Cutaneous Lymphoma French Study Group for diagnosis of cutaneous lymphoproliferations]

Author

Menguy, Sarah, Mansour, Yara, Jullié, Marie-Laure, Augereau, Olivier, Ortonne, Nicolas, Balme, Brigitte, Battistella, Maxime, Lamant, Laurence, Beltzung, Fanny, Szablewski, Vanessa, Gaulard, Philippe, Bagot, Martine, Beylot-Barry, Marie, Vergier, Béatrice, Université de Bordeaux (UB), CHU Bordeaux [Bordeaux], Bordeaux Research In Translational Oncology [Bordeaux] (BaRITOn), Université de Bordeaux (UB)-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de pathologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Toulouse [Toulouse], CHU Clermont-Ferrand, Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université des Antilles (UA)-Etablissement français du don du sang [Montpellier], Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), and Hôpital Henri Mondor

Subjects
MESH: Humans, Skin Neoplasms, MESH: Skin Neoplasms, MESH: Algorithms, MESH: Retrospective Studies, MESH: Lymphoma, T-Cell, Cutaneous, Lymphoma, T-Cell, Cutaneous, Cutaneous lymphoma, Diagnostic algorithms, Lymphomes cutanés, MESH: Sezary Syndrome, Algorithme diagnostique, Humans, Sezary Syndrome, French Study Group of Cutaneous Lymphomas, Groupe français d’étude des lymphomes cutanés, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Algorithms, Retrospective Studies
Abstract

International audience; After a first diagnosis proposition, management of cutaneous lymphomas requires a systematic review by an expert pathologist and each case is presented to a multidisciplinary meeting in the setting of the French Study Group of Cutaneous Lymphomas to propose an adequate treatment. A retrospective study of the 2760 cutaneous lymphoproliferations retrieved between 2010 and 2011 were analyzed and demonstrated the interest of diagnostic algorithms we built with the group. The objective of our study was to compare two cohorts from 2010-2011 and 2015-2017 regarding the proportion of cases sent for validation or expertise, the concordance and mismatch rates and potential diagnostic issues using our diagnostic algorithms. Between 2015-2017, 5640 skin lymphoproliferation cases were examined. It appeared that Pathologists were more confident and effective in finding the right diagnosis. Indeed, the rate of concordant diagnosis increased from 57% to 67%. Moreover, in comparison with the 2010-2011 concordant cases sent for expertise, 73.5% of concordant cases were sent for validation in 2015-2017. 14% of cases remained discordant, mainly sent for expertise. Furthermore, half of questionable cases (26.3%) were resolved after expertise, and 12.1% cases remained unsolved. These priority cases are important to be presented at multidisciplinary meeting. The analysis of discordant and doubtful cases unveiled recurrent diagnostic problems for which we proposed appropriate diagnostic algorithms including large B cell lymphomas, CD4+ T cell lymphoproliferations, epidermotropic CD8+ T-cell lymphoproliferations and the differential diagnosis of mycosis fongoïdes/Sezary syndrome versus inflammatory dermatitis.

Published
2020

159. FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T cell lymphoma, not otherwise specified

Author

Debackere, Koen, primary, Marcelis, Lukas, additional, Demeyer, Sofie, additional, Bempt, Marlies Vanden, additional, Mentens, Nicole, additional, Gielen, Olga, additional, Jacobs, Kris, additional, Broux, Michael, additional, Verhoef, Gregor, additional, Michaux, Lucienne, additional, Graux, Carlos, additional, Wlodarska, Iwona, additional, Gaulard, Philippe, additional, de Leval, Laurence, additional, Tousseyn, Thomas, additional, Cools, Jan, additional, and Dierickx, Daan, additional

Published
2021
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162. A randomized phase 3 trial of auto vs. allo transplantation as part of first-line therapy in poor-risk peripheral T-NHL

Author

Schmitz, Norbert, primary, Truemper, Lorenz H, additional, Bouabdallah, Krimo, additional, Ziepert, Marita, additional, Leclerc, Mathieu, additional, Cartron, Guillaume, additional, Jaccard, Arnaud, additional, Reimer, Peter, additional, Wagner-Drouet, Eva Maria, additional, Wilhelm, Martin, additional, Sanhes, Laurence, additional, Lamy, Thierry, additional, de Leval, Laurence, additional, Rosenwald, Andreas, additional, Roussel, Murielle, additional, Kroschinsky, Frank P, additional, Lindemann, Walter Walter, additional, Dreger, Peter, additional, Viardot, Andreas, additional, Milpied, Noel J, additional, Gisselbrecht, Christian, additional, Wulf, Gerald G, additional, Gyan, Emmanuel, additional, Gaulard, Philippe, additional, Bay, Jacques-Olivier, additional, Glass, Bertram, additional, Poeschel, Viola, additional, Damaj, Gandhi, additional, Sibon, David, additional, Delmer, Alain Jacques, additional, Bilger, Karin, additional, Banos, Anne, additional, Haenel, Mathias, additional, Dreyling, Martin, additional, Metzner, Bernd, additional, Keller, Ulrich, additional, Braulke, Friederike, additional, Friedrichs, Birte, additional, Nickelsen, Maike, additional, Altmann, Bettina, additional, and Tournilhac, Olivier, additional

Published
2020
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166. Another look at follicular lymphoma: immunophenotypic and molecular analyses identify distinct follicular lymphoma subgroups

Author

Marafioti, Teresa, Copie-Bergman, Christiane, Calaminici, Maria, Paterson, Jennifer C, Shende, Vishvesh H, Liu, Hongxiang, Baia, Maryse, Ramsay, Alan D, Agostinelli, Claudio, Brière, Josette, Clear, Andrew, Du, Ming-Qing, Piccaluga, Pier Paolo, Masir, Noraidah, Nacheva, Elizabeth P, Sujobert, Pierre, Shanmugam, Kandavel, Grogan, Thomas M, Brooks, Simon P, Khwaja, Asim, Ardeshna, Kirit, Townsend, William, Pileri, Stefano A, Haioun, Corinne, Linch, David, Gribben, John G, Gaulard, Philippe, and Isaacson, Peter G

Published
2013
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167. ESMO Guidelines consensus conference on malignant lymphoma 2011 part 1: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL)

Author

Ghielmini, M., Vitolo, U., Kimby, E., Montoto, S., Walewski, J., Pfreundschuh, M., Federico, M., Hoskin, P., McNamara, C., Caligaris-Cappio, F., Stilgenbauer, S., Marcus, R., Trneny, M., Dreger, P., Montserrat, E., Dreyling, M., Agostinelli, Claudio, Arcaini, Luca, Caligaris-Cappio, Federico, Campo, Elias, Coiffier, Bertrand, Corradini, Paolo, DʼAmore, Francesco, Dreger, Peter, Dreyling, Martin, Federico, Massimo, Gallamini, Andrea, Gaulard, Philippe, Geisler, Christian H., Ghielmini, Michele, Gisselbrecht, Christian, da Silva, Maria Gomes, Gribben, John, Hermine, Olivier, Hoskin, Peter, Iannitto, Emilio, Kim, Won Seog, Kimby, Eva, Kluin-Nelemans, Hanneke C., Koch, Peter, Ladetto, Marco, Le Gouill, Steven, Lopez-Guillermo, Armando, Marcus, Robert, McNamara, Christopher, Montalban, Carlos, Montoto, Silvia, Montserrat, Emili, Pfreundschuh, Michael, Raderer, Markus, Rodriguez, José, Salles, Gilles, Bernard, Claude, Schmitz, Norbert, Shpilberg, Ofer, Stilgenbauer, Stephan, Thieblemont, Catherine, Tilly, Hervé, Tournilhac, Olivier, Trümper, Lorenz, Vitolo, Umberto, Walewski, Jan, Wotherspoon, Andrew, and Zucca, Emanuele

Published
2013
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169. Contributors

Author

Abati, Andrea, primary, Arber, Daniel A., additional, Atayar, Çiğdem, additional, Bagg, Adam, additional, Bain, Barbara J., additional, Barry, Todd S., additional, Borowitz, Michael J., additional, Brousset, Pierre, additional, Brynes, Russell K., additional, Camacho, Francisca I., additional, Campo, Elias, additional, Chacón, Ignacio, additional, Chaganti, R.S.K., additional, Chan, Alexander C.L., additional, Chan, John K.C., additional, Chan, Wing C. (John), additional, Chang, Karen L., additional, Cheuk, Wah, additional, Connors, Joseph M., additional, Craig, Fiona E., additional, de la Cruz Mora, Miguel Ángel, additional, Delsol, Georges, additional, Djokic, Miroslav, additional, Duncan, Lyn McDivitt, additional, Elenitoba-Johnson, Kojo S.J., additional, Facchetti, Fabio, additional, Fend, Falko, additional, Ferry, Judith A., additional, Filie, Armando C., additional, Foucar, Kathryn, additional, García, Juan F., additional, Gascoyne, Randy D., additional, Gaulard, Philippe, additional, Greiner, Timothy C., additional, Hamilton, Katherine S., additional, Harris, Nancy Lee, additional, Hasserjian, Robert P., additional, Head, David R., additional, Heerema-McKenney, Amy, additional, Horny, Hans-Peter, additional, Houldsworth, Jane, additional, Hsi, Eric D., additional, Hutchison, Robert E., additional, Hyjek, Elizabeth, additional, Isaacson, Peter G., additional, Jaffe, Elaine S., additional, Jaffe, Ronald, additional, Jares, Pedro, additional, Jones, Dan, additional, Kadin, Marshall E., additional, Ko, Young Hyeh, additional, Kroft, Steven H., additional, Kumar, Shimareet, additional, Lamant-Rochaix, Laurence, additional, LeBoit, Philip E., additional, de Leval, Laurence, additional, Lim, Megan S., additional, McKenna, Robert W., additional, Medeiros, L. Jeffrey, additional, Mollejo, Manuela, additional, Montgomery, Karen Dyer, additional, Nanjangud, Gouri, additional, Natkunam, Yasodha, additional, Nelson, Beverly P., additional, Nguyen, Phuong L., additional, O’Malley, Dennis P., additional, Orazi, Attilio, additional, Ott, German, additional, Palanisamy, Nallasivam, additional, Peterson, LoAnn C., additional, Piris, Miguel A., additional, Pittaluga, Stefania, additional, Poppema, Sibrand, additional, Porwit, Anna, additional, Quintanilla-Martinez,, Priv.Doz.Dr. Leticia, additional, Racke, Frederick Karl, additional, Raffeld, Mark, additional, Ralfkiaer, Elisabeth, additional, Rezk, Sherif A., additional, Rosenthal, Nancy S., additional, Said, Jonathan, additional, Schnitzer, Bertram, additional, Siebert, Reiner, additional, Sotlar, Karl, additional, Stetler-Stevenson, Maryalice, additional, Sullivan, John L., additional, Swerdlow, Steven H., additional, Valent, Peter, additional, Vardiman, James W., additional, Viswanatha, David S., additional, Warnke, Roger A., additional, Weir, Edward G., additional, Weiss, Lawrence M., additional, Wilson, Carla S., additional, Woda, Bruce A., additional, Yuan, Constance M., additional, and Zhou, Fan, additional

Published
2011
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172. CHOP chemotherapy plus rituximab compared wiht CHOP alone in elderly patients with diffuse largeB-cell lymphoma

Author

Coiffier, Bertrand, Lepage, Eric, Briere, Josette, Herbrecht, Raoul, Tilly, Herve, Bouabdallah, Reda, Morel, Pierre, Neste, Eric van den, Salles, Gilles, Gaulard, Philippe, Reyes, Felix, and Gisselbrecht, Christian

Subjects
Lymphomas, Monoclonal antibodies -- Health aspects
Abstract

Adding the drug rituximab to CHOP chemotherapy for elderly patients with diffuse large-B-cell lymphoma can increase their survival, according to a study of 399 patients. Rituximab is a monoclonal antibody that blocks the activity of B cells.

Published
2002

179. Final Analysis of the International Double-Blind Randomized Phase III Study of Lenalidomide Maintenance in Elderly Patients with DLBCL in Response after R-CHOP, the Remarc Study from Lysa

Author

Thieblemont, Catherine, primary, Gomes da Silva, Maria, additional, Casasnovas, Olivier, additional, Ghesquieres, Hervé, additional, Damaj, Gandhi Laurent, additional, Trotman, Judith, additional, Feugier, Pierre, additional, Haioun, Corinne, additional, Greil, Richard, additional, Caballero, Dolores, additional, Lopez-Guillermo, Armando, additional, Grosicki, Sebastian, additional, Van Eygen, Koen, additional, Snauwaert, Sylvia, additional, Lech-Marańda, Ewa, additional, Heibl, Sonja, additional, Catalano, John, additional, Cohen, Amos, additional, Cairoli, Anne, additional, Gaulard, Philippe, additional, Morschhauser, Franck, additional, and Tilly, Herve, additional

Published
2020
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180. Addition of Brentuximab Vedotin to Gemcitabine in Relapsed or Refractory T-Cell Lymphoma: Results of a Lysa Multicenter, Phase II Study. "the TOTAL Trial"

Author

Tournilhac, Olivier, primary, Hacini, Maya, additional, Bouabdallah, Kamal, additional, Laribi, Kamel, additional, Maerevoet, Marie, additional, Ysebaert, Loic, additional, Guidez, Stephanie, additional, Le Gouill, Steven, additional, André, Marc, additional, Dupuis, Jehan, additional, Thieblemont, Catherine, additional, Bachy, Emmanuel, additional, Daguindau, Nicolas, additional, Morschhauser, Franck, additional, Tricot, Sabine, additional, Feugier, Pierre, additional, Banos, Anne, additional, Lamy De La Chapelle, Thierry, additional, Chauchet, Adrien, additional, Gyan, Emmanuel, additional, Cartron, Guillaume, additional, Farhat, Hassan, additional, Camus, Vincent, additional, Drenou, Bernard, additional, Zerazhi, Hacene, additional, Sibon, David, additional, Nicolas-Virelizier, Emmanuelle, additional, Delette, Caroline, additional, Snauwaert, Sylvia, additional, Straetmans, Nicole, additional, Delarue, Richard, additional, Parrens, Marie, additional, Bossard, Céline, additional, De Leval, Laurence, additional, Gaulard, Philippe, additional, and Damaj, Gandhi Laurent, additional

Published
2020
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181. Final Analysis of the Ro-CHOP Phase III Study (Conducted by LYSA): Romidepsin Plus CHOP in Patients with Peripheral T-Cell Lymphoma

Author

Bachy, Emmanuel, primary, Camus, Vincent, additional, Thieblemont, Catherine, additional, Casasnovas, Rene-Olivier, additional, Ysebaert, Loic, additional, Damaj, Gandhi Laurent, additional, Guidez, Stephanie, additional, Pica, Gian-Matteo, additional, Kim, Won Seog, additional, Lim, Soon Thye, additional, André, Marc, additional, Martin Garcia-Sancho, Alejandro, additional, Penarrubia Ponce, Maria Jesus, additional, Staber, Philipp B., additional, Trotman, Judith, additional, Hüttmann, Andreas, additional, Stefoni, Vittorio, additional, Re, Alessandro, additional, Gaulard, Philippe, additional, Delfau-Larue, Marie-Helene, additional, De Leval, Laurence, additional, Meignan, Michel, additional, Li, Ju, additional, Morschhauser, Franck, additional, and Delarue, Richard, additional

Published
2020
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182. Nivolumab in Combination with Gemcitabine and Oxaliplatin (GemOx) in Relapse/Refractory T-Cell Lymphoma: Preliminary Results of the Experimental Arm of the Niveau Trial

Author

Houot, Roch, primary, Poeschel, Viola, additional, Altmann, Bettina, additional, Illmer, Thomas, additional, André, Marc, additional, Dreyling, Martin, additional, Maisonneuve, Herve, additional, Tilly, Herve, additional, Mayer, Stephanie, additional, Casasnovas, Rene-Olivier, additional, Le Gouill, Steven, additional, Offner, Fritz C., additional, Cartron, Guillaume, additional, Kerkhoff, Andrea, additional, Weber, Thomas, additional, Hoffmann, Joerg, additional, Ziepert, Marita, additional, Klapper, Wolfram, additional, Itti, Emmanuel, additional, Hellwig, Dirk, additional, De Leval, Laurence, additional, Rosenwald, Andreas, additional, Haioun, Corinne, additional, Dercle, Laurent, additional, Gaulard, Philippe, additional, and Held, Gerhard, additional

Published
2020
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183. Controversies in the Treatment of Peripheral T-cell Lymphoma

Author

Bachy, Emmanuel, primary, Broccoli, Alessandro, additional, Dearden, Claire, additional, de Leval, Laurence, additional, Gaulard, Philippe, additional, Koch, Raphael, additional, Morschhauser, Franck, additional, Trümper, Lorenz, additional, and Zinzani, Pier Luigi, additional

Published
2020
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184. Reply to M. Romero et al

Author

Jaffe, Elaine S., primary, Feldman, Andrew L., additional, Gaulard, Philippe, additional, Miranda, Roberto N., additional, and Sohani, Aliyah R., additional

Published
2020
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185. Effect of expression of ICOS in cutaneous T-cell lymphoma and its targeting on killing of malignant cells.

Author

Amatore, Florent, primary, Ortonne, Nicolas, additional, Lopez, Marc, additional, Orlanducci, Florence, additional, Castellano, Rémy, additional, Ingen-Housz-Oro, Saskia, additional, Decroos, Amandine, additional, Gorvel, Laurent, additional, Goubard, Armelle, additional, Bouabdallah, Reda, additional, Bonnet, Nathalie, additional, Grob, Jean-Jacques, additional, Gaulard, Philippe, additional, Bagot, Martine, additional, Bensussan, Armand, additional, Berbis, Philippe, additional, and Olive, Daniel, additional

Published
2020
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186. High total metabolic tumor volume at baseline predicts survival independent of response to therapy

Author

Vercellino, Laetitia, primary, Cottereau, Anne-Segolene, primary, Casasnovas, Olivier, primary, Tilly, Hervé, primary, Feugier, Pierre, primary, Chartier, Loic, primary, Fruchart, Christophe, primary, Roulin, Louise, primary, Oberic, Lucie, primary, Pica, Gian Matteo, primary, Ribrag, Vincent, primary, Abraham, Julie, primary, Simon, Marc, primary, Gonzalez, Hugo, primary, Bouabdallah, Reda, primary, Fitoussi, Olivier, primary, Sebban, Catherine, primary, López-Guillermo, Armando, primary, Sanhes, Laurence, primary, Morschhauser, Franck, primary, Trotman, Judith, primary, Corront, Bernadette, primary, Choufi, Bachra, primary, Snauwaert, Sylvia, primary, Godmer, Pascal, primary, Briere, Josette, primary, Salles, Gilles, primary, Gaulard, Philippe, primary, Meignan, Michel, primary, and Thieblemont, Catherine, primary

Published
2020
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189. EBV+ diffuse large B-cell lymphoma associated with chronic inflammation expands the spectrum of breast implant-related lymphomas

Author

Mescam, Lénaïg, primary, Camus, Vincent, primary, Schiano, Jean-Marc, primary, Adélaïde, José, primary, Picquenot, Jean-Michel, primary, Guille, Arnaud, primary, Bannier, Marie, primary, Ruminy, Philippe, primary, Viailly, Pierre-Julien, primary, Jardin, Fabrice, primary, Bouabdallah, Reda, primary, Brenot Rossi, Isabelle, primary, Bohers, Elodie, primary, Robe, Cyrielle, primary, Laurent, Camille, primary, Birnbaum, Daniel, primary, Wotherspoon, Andrew, primary, Gaulard, Philippe, primary, and Xerri, Luc, primary

Published
2020
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190. Prognostic Significance of MYC Rearrangement and Translocation Partner in Diffuse Large B-Cell Lymphoma: A Study by the Lunenburg Lymphoma Biomarker Consortium

Author

Rosenwald, Andreas, primary, Bens, Susanne, additional, Advani, Ranjana, additional, Barrans, Sharon, additional, Copie-Bergman, Christiane, additional, Elsensohn, Mad-Helenie, additional, Natkunam, Yaso, additional, Calaminici, Maria, additional, Sander, Birgitta, additional, Baia, Maryse, additional, Smith, Alexandra, additional, Painter, Daniel, additional, Pham, Luu, additional, Zhao, Shuchun, additional, Ziepert, Marita, additional, Jordanova, Ekaterina S., additional, Molina, Thierry J., additional, Kersten, Marie José, additional, Kimby, Eva, additional, Klapper, Wolfram, additional, Raemaekers, John, additional, Schmitz, Norbert, additional, Jardin, Fabrice, additional, Stevens, Wendy B.C., additional, Hoster, Eva, additional, Hagenbeek, Anton, additional, Gribben, John G., additional, Siebert, Reiner, additional, Gascoyne, Randy D., additional, Scott, David W., additional, Gaulard, Philippe, additional, Salles, Gilles, additional, Burton, Catherine, additional, de Jong, Daphne, additional, Sehn, Laurie H., additional, and Maucort-Boulch, Delphine, additional

Published
2019
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193. The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms

Author

Borie, Claire, Colas, Chrystelle, Dartigues, Peggy, Lazure, Thierry, Rince, Patricia, Buhard, Olivier, Folliot, Patrick, Chalastanis, Alexandra, Muleris, Martine, Hamelin, Richard, Mercier, Dominique, Oliveira, Carla, Seruca, Raquel, Chadburn, Amy, Leblond, Véronique, Barete, Stéphane, Gaïdano, Gianluca, Martin, Antoine, Gaulard, Philippe, Fléjou1, Jean-François, Raphael, Martine, and Duval, Alex

Published
2009
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196. Nodal cytotoxic peripheral T-cell lymphoma occurs frequently in the clinical setting of immunodysregulation and is associated with recurrent epigenetic alterations

Author

Nicolae, Alina, Bouilly, Justine, Lara, Diane, Fataccioli, Virginie, Lemonnier, François, Drieux, Fanny, Parrens, Marie, Robe, Cyrielle, Poullot, Elsa, Bisig, Bettina, Bossard, Céline, Letourneau, Audrey, Missiaglia, Edoardo, Bonnet, Christophe, Szablewski, Vanessa, Traverse-Glehen, Alexandra, Delfau-Larue, Marie-Hélène, de Leval, Laurence, and Gaulard, Philippe

Abstract

Nodal peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) with cytotoxic phenotype is overall rare, with most reports coming from Asia. Given its elusive pathobiology, we undertook a clinicopathological and molecular study of 54 Western patients diagnosed with PTCL, NOS expressing cytotoxic molecules, within a lymph node. More commonly males (M/F-2,6/1) with median age of 60 years were affected. Besides lymphadenopathy, 87% of patients had ≥1 involved extranodal site. High-stage disease (III-IV), International Prognostic Index >2, B symptoms, LDH level, and cytopenia(s) were observed in 92, 63, 67, 78, and 66% of cases, respectively. Ten patients had a history of B-cell malignancies, one each of myeloid neoplasm, breast or prostate cancer, and 4 others had underlying immune disorders. Most patients (70%) died, mostly of disease, with a median overall survival of 12.7 months. Immunophenotypically, the neoplastic lymphocytes were T-cell receptor (TCR) αβ + (47%), TCR-silent (44%) or TCRγδ+ (10%), commonly CD8 + (45%) or CD4-CD8- (32%). All except one had an activated cytotoxic profile, and 95% were subclassified into PTCL-TBX21 subtype based on CXCR3, TBX21, and GATA3 expression pattern. Seven patients (13%) disclosed EBER + tumor cells. Targeted DNA deep-sequencing (33 cases) and multiplex ligation-dependent reverse transcription-polymerase chain reaction assay (43 cases) identified frequent mutations in epigenetic modifiers (73%), including TET2(61%) and DNMT3A(39%), recurrent alterations affecting the TCR (36%) and JAK/STAT (24%) signaling pathways and TP53mutations (18%). Fusion transcripts involving VAV1were identified in 6/43 patients (14%). Patients with nodal cytotoxic PTCL, NOS have an aggressive behavior and frequently present in a background of impaired immunity, although the association with Epstein-Barr virus is rare. The recurrent alterations in genes involved in DNA methylation together with genes related to cytokine or TCR signaling, suggest that co-operation of epigenetic modulation with cell-signaling pathways plays a critical role in the pathogeny of these lymphomas.

Published
2022
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197. Defining the signatures of peripheral T-cell lymphoma, with a targeted 20-markers gene expression profiling assay (RT-MLPA)

Author

Drieux, Fanny, Ruminy, Philippe, Abdel-Sater, Ahmad, Lemonnier, François, Viailly, Pierre-Julien, Fataccioli, Virginie, Machand, Vinciane, Bisig, Bettina, Letourneau, Audrey, Parrens, Marie, Bossard, Céline, Bruneau, Julie, Dobay, Pamela, Veresezan, Liana, Dupuy, Aurélie, Pujals, Anaïs, Robe, Cyrielle, Sako, Nouhoum, Copie-Bergman, Christiane, Delfau-Larue, Marie-Hélène, Picquenot, Jean-Michel, Tilly, Hervé, Delarue, Richard, Jardin, Fabrice, de Leval, Laurence, Gaulard, Philippe, Service d'Anatomie et Cytologie Pathologique [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Pathology, Centre Hospitalier Universitaire Sart Tilman, Service de pathologie [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Laboratoire d'anatomie et cytologie pathologiques, Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire d'anatomie et cythologie pathologique, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Cellectis SA, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Département de pathologie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service d'immunologie biologique, Service d'immuno-hématologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Pathology, and CHU Sart-Tilman

Subjects
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.CAN]Life Sciences [q-bio]/Cancer, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

198. MYCRearrangement Prediction From LYSA Whole Slide Images in Large B-Cell Lymphoma: A Multicentric Validation of Self-supervised Deep Learning Models

Author

Syrykh, Charlotte, Di Proietto, Valentina, Brion, Eliott, Copie-Bergman, Christiane, Jardin, Fabrice, Dartigues, Peggy, Gaulard, Philippe, Molina, Thierry Jo, Briere, Josette, Oberic, Lucie, Haioun, Corine, Tilly, Hervé, Maussion, Charles, Morel, Mehdi, Schiratti, Jean-Baptiste, and Laurent, Camille

Abstract

Large B-cell lymphoma (LBCL) is a heterogeneous lymphoid malignancy in which MYCgene rearrangement (MYC-R) is associated with a poor prognosis, prompting the recommendation for more intensive treatment. MYC-R detection relies on fluorescence in situ hybridization method which is time consuming, expensive, and not available in all laboratories. Automating MYC-R detection on hematoxylin-and-eosin–stained whole slide images of LBCL would decrease the need for costly molecular testing and improve pathologists’ productivity. We developed an interpretable deep learning algorithm to detect MYC-R considering recent advances in self-supervised learning and providing an extensive comparison of 7 feature extractors and 6 multiple instance learning models, themselves. Four different multicentric cohorts, including 1247 patients with LBCL, were used for training and validation. The best deep learning model reached an average area under the receiver operating characteristic curve score of 81.9% during crossvalidation on the largest LBCL cohort, and area under the receiver operating characteristic curve scores ranging from 62.2% to 74.5% when evaluated on other unseen cohorts. In addition, we demonstrated that using this model as a prescreening tool (with a false-negative rate of 0%), fluorescence in situ hybridization testing would be avoided in 35% of cases. This work demonstrates the feasibility of developing a medical device to efficiently detect MYCgene rearrangement on hematoxylin-and-eosin–stained whole slide images in daily practice.

Published
2024
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