Search

A search for a new Z′ gauge boson associated with (un)broken B-L symmetry in the keV-GeV mass range is carried out for the first time using the missing-energy technique in the NA64 experiment at the CERN SPS. From the analysis of the data with 3.22×1011 electrons on target collected during 2016-2021 runs, no signal events were found. This allows us to derive new constraints on the Z′-e coupling strength, which, for the mass range 0.3mZ′ 100 MeV, are more stringent compared to those obtained from the neutrino-electron scattering data., Physical Review Letters, 129 (16), ISSN:0031-9007, ISSN:1079-7114

The extension of Standard Model made by inclusion of additional U(1) gauge Lμ-Lτ symmetry can explain the difference between the measured and the predicted value of the muon magnetic moment and solve the tension in B meson decays. This model predicts the existence of a new, light Z′ vector boson, predominantly coupled to second and third generation leptons, whose interaction with electrons is due to a loop mechanism involving muons and taus. In this work, we present a rigorous evaluation of the upper limits in the Z′ parameter space, obtained from the analysis of the data collected by the NA64-e experiment at CERN SPS, that performed a search for light dark matter with 2.84×1011 electrons impinging with 100 GeV on an active thick target. The resulting limits touch the muon g-2 preferred band for values of the Z′ mass of order of 1 MeV, while the sensitivity projections for the future high-statistics NA64-e runs demonstrate the power of the electrons/positron beam approach in this theoretical scenario., Physical Review D, 106 (3), ISSN:1550-7998, ISSN:0556-2821, ISSN:1550-2368

By virtue of art. 396 paragraph 5 of the Criminal Procedure Code as related to art. 16 paragraph 1 letter c of the Criminal Procedure Code, the Appeal Court shall hereby acquit the defendant S.C. F. S.A. for the commitment of the crime relating to “unauthorized reproduction of computer programs on computation systems”, which is stipulated under art. 139 index 9 of Law no. 8 / 1996, as republished. The Court shall hereby deny the civil action filed by the civil parties Microsoft Corporation and Autodesk Incorporates. Convicting the defendant S.C. F. S.A. cannot be done based upon suppositions and presumptions, instead it has to be based on certain and solid proof of guilt, which is missing within the present case file. The prosecutor’s office has failed to conduct one complete and effective investigation within the meaning of collecting evidence able to prove, beyond reasonable doubt, the actual charges brought against the defendant. The Court, in the absence of any certain and material evidence regarding the installation and use of the 14 design program of “AUTOCAD” range, belonging to Autodesk Incorporated, and of one Windows 7 Ultimate program belonging to Microsoft Corporation, may not engage the criminal liability of the defendant S.C. F. S.A., and the acquittal solution issued by the court of first instance is legal and grounded.

The current most stringent constraints for the existence of sub-GeV dark matter coupling to Standard Model via a massive vector boson $A^\prime$ were set by the NA64 experiment for the mass region $m_{A^\prime}\lesssim 250$ MeV, by analyzing data from the interaction of $2.84\cdot10^{11}$ 100-GeV electrons with an active thick target and searching for missing-energy events. In this work, by including $A^\prime$ production via secondary positron annihilation with atomic electrons, we extend these limits in the $200$-$300$ MeV region by almost an order of magnitude, touching for the first time the dark matter relic density constrained parameter combinations. Our new results demonstrate the power of the resonant annihilation process in missing energy dark-matter searches, paving the road to future dedicated $e^+$ beam efforts.

et al., We present results of the Relic Axion Dark-Matter Exploratory Setup (RADES), a detector which is part of the CERN Axion Solar Telescope (CAST), searching for axion dark matter in the 34.67 μeV mass range. A radio frequency cavity consisting of 5 sub-cavities coupled by inductive irises took physics data inside the CAST dipole magnet for the first time using this filter-like haloscope geometry. An exclusion limit with a 95% credibility level on the axion-photon coupling constant of gaγ ≳ 4 × 10−13 GeV−1 over a mass range of 34.6738 μeV < ma < 34.6771 μeV is set. This constitutes a significant improvement over the current strongest limit set by CAST at this mass and is at the same time one of the most sensitive direct searches for an axion dark matter candidate above the mass of 25 μeV. The results also demonstrate the feasibility of exploring a wider mass range around the value probed by CAST-RADES in this work using similar coherent resonant cavities., Article funded by SCOAP3., This work has been funded by the Spanish Agencia Estatal de Investigacion (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) under project FPA-2016-76978-C3-2-P (supported by the grant FPI BES-2017-079787) and PID2019-108122GB-C33, and was supported by the CERN Doctoral Studentship programme. The research leading to these results has received funding from the European Research Council and BD, JG and SAC acknowledge support through the European Research Council under grant ERC-2018-StG-802836 (AxScale project). BD also acknowledges fruitful discussions at MIAPP supported by DFG under EXC-2094 – 390783311. IGI acknowledges also support from the European Research Council (ERC) under grant ERC-2017-AdG-788781 (IAXO+ project). JR has been supported by the Ramon y Cajal Fellowship 2012-10597, the grant PGC2018-095328-BI00(FEDER/Agencia estatal de investigación) and FSE-DGA2017-2019-E12/7R (Gobierno de Aragón/FEDER) (MINECO/FEDER), the EU through the ITN “Elusives” H2020-MSCA-ITN-2015/674896 and the Deutsche Forschungsgemeinschaft under grant SFB-1258 as a Mercator Fellow. CPG was supported by PROMETEO II/2014/050 of Generalitat Valenciana, FPA2014-57816-P of MINECO and by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreements 690575 and 674896. AM is supported by the European Research Council under Grant No. 742104.

Artificial intelligence (AI) is described as the joint set of data entry, able to receive inputs, interpret and learn from such feedbacks, and display related and flexible independent actions that help the entity reach a specific aim over a period of time. By extending its health-care applications continuously, the ultimate AI target is to use machine simulation of human intelligence processes such as learning, reasoning, and self-correction, to mimic human behaviour. AI is extensively used in diverse sectors of medicine, including clinical trials, drug discovery and development, understanding of target-disease associations, disease prediction, imaging, and precision medicine. In this review, we firstly describe the limitations and challenges of the AI tools and techniques utilized in medicine, followed by current uses and applications of AI in the translational field, highlighting the cardio-renal preclinical models with potential to contribute to future clinical research.

Wound dressings under the form of films constituted of modified alginate (methacrylated alginate - AlgMA) versus a gelatine derivative containing norbornene functionalities (GelNB) are developed and evaluated for their moisturizing effects, followed by further in vivo testing to assay their wound healing potential. The gel fraction results shows that AlgMA and GelNB films displayed a high crosslinking efficiency while the swelling assay reveals a stronger water uptake capacity for AlgMA films compared to GelNB and to commercial dressing AquacelAg, used as positive control. Referring to the in vivo wound healing effect, the GelNB films not only exhibit proper healing properties, yet is higher to the AquacelAg, while the AlgMA films exhibit similar wound healing effect as the positive control. On a microscopic level, the healing phases (from inflammation to proliferation and contraction) are present for both materials, yet at a faster rate for the GelNB films, which is in line with the macroscopic findings. These results provide data which support that GelNB films outperform AlgMA films, but both can be used for wound healing applications.

The present study examined positive and negative effects of health communication on the fight against the COVID-19 under lockdown, during the first wave of the pandemic in Greece. An online survey (N = 1,199) examined the relationships among media trust, emotional and cognitive reactions to COVID-19 information overload, media attention, and risk perceptions regarding COVID-19. Participants' media attention (exposure and attention combined) to information about the pandemic was positively related to their risk perceptions (perceived susceptibility and severity) about the disease. Media attention was dependent on participants' trust in the media as valid sources of information, but also on their cognitive and emotional reactions to COVID-19 information overload. In response to this overload, they produced negative thoughts and more negative (fear and anger) than positive (protection) emotions. These distinct reactions had differential effects on media attention and risk perceptions. Fear and protection were positively related to media attention and risk perceptions, while anger and negative thinking undermined attention and perceptions. Furthermore, all reactions depended on media trust, which mediated the effect on media attention. These findings highlighted desirable and some undesirable effects of health communication in the fight against COVID-19, which can be used to improve health communication in the future.

Considerable research on music psychology indicates correlations between musical preferences and individual differences in personality, between the various uses of music and personality traits, and between musical preferences and personal values. However, the association between personal values and the multiple ways in which music is used has not been considered yet. To investigate this issue, 400 participants completed a self-report questionnaire comprising the uses of music, personality traits, and personal values, as well as provided their demographic details. The hierarchical regression analyses revealed that both personality and personal values along with gender contribute differentially to predicting the different ways in which music is used. Overall, these findings suggest that the understanding of the ways in which listeners experience music can be improved by contemplating various individual difference variables.

Introduction. There is accumulating evidence that high normal serum uric acid (SUA) levels of 6-7 mg/dL are associated with cardiovascular morbidity and metabolic syndrome (MetS), hence the need to redefine its upper limit of normal (ULN). We aimed to derive ULN based on statistics and evidence in a representative sample of the population and to observe its relation to MetS components. Methods. All SUA measurements form a university rheumatology hospital were extracted between January 5th 2010 and March 21st 2018. SUA levels were measured by a single biochemist a unique type of commercially available kit. Follow-up measurements, patients with diagnoses influencing SUA levels and outlying measurements were excluded. ULNs were studied using least square analysis. Results. Of the 22503 SUA measurements in the database, only 3318 came from normal individuals: 33.3% men (n=1105), 66.7% women (n = 2213). Least square analysis revealed the following SUA reference intervals (RI): 3.43-6.19 mg/dL for the combined sample; 4.44-7.01 mg/dL for men, 3.28-5.56 mg/dL for women. The values corresponding to the 66th percentile of each group presented lower ULNs: 5.36 mg/dL for all, 6.10 mg/dL for men, 4.90 mg/dL for women. The prevalence of hyperuricemia increased from 13.8% (manufacturer’s gender-specific ULN) to 19.9% (derived ULN). Mean SUA levels significantly increased with the number of MetS components. Conclusion. We recommend that hyperuricemia should be defined using a statistical approach of ULN selection corresponding to the genderand population-specific 66th percentile of data range.

We performed a search for a new generic X boson, which could be a scalar (S), pseudoscalar (P), vector (V), or an axial vector (A) particle produced in the 100 GeV electron scattering off nuclei, e^{-}Z→e^{-}ZX, followed by its invisible decay in the NA64 experiment at CERN. No evidence for such a process was found in the full NA64 dataset of 2.84×10^{11} electrons on target. We place new bounds on the S, P, V, A coupling strengths to electrons, and set constraints on their contributions to the electron anomalous magnetic moment a_{e}, |Δa_{X}|≲10^{-15}-10^{-13} for the X mass region 1 MeV≲m_{X}≲1 GeV. These results are an order of magnitude more sensitive compared to the current accuracy on a_{e} from the electron g-2 experiments and recent high-precision determination of the fine structure constant.

Improving wound healing by developing innovative dressing materials has been an important focus over the past few years in the biomedical field. In this regard, the current study focuses on developing new dressings based on acrylate-endcapped urethane-based polymers (AUPs). The materials have been processed into films and electrospun mats. Exudate uptake capacity, mechanical properties and fiber morphology were evaluated herein. The results showed superior uptake capacity of both films and mats when compared to Aquacel®Ag, Exufiber® and Help®. Addition of a high molar mass poly(ethylene glycol) to the AUP polymers benefits both the film and electrospun dressings in terms of flexibility and elongation. An in vivo study was conducted to assess the wound healing properties of these dressings on an acute wound model induced to rats. A macroscopic evaluation indicated that wound contraction and wound fraction percentages were improved significantly in case of the AUP-materials when compared to both the positive (Aquacel®Ag) and negative (Exufiber® and Help®) controls. A histopathological assay, to underline the changes noticed on a macroscopical level, was also performed. The data obtained proved that the developed dressings are beneficial towards tissue regeneration and accelerated wound healing. These findings offer a practical yet adequate strategy for the fabrication of acrylate-endcapped urethane-based materials for wound healing applications. ispartof: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS vol:130 ispartof: location:Netherlands status: published

We report the results of a search for a light pseudoscalar particle $a$ that couples to electrons and decays to $e^+e^-$ performed using the high-energy CERN SPS H4 electron beam. If such pseudoscalar with a mass $\simeq 17$ MeV exists, it could explain the ATOMKI anomaly. We used the NA64 data samples collected in the "visible mode" configuration with total statistics corresponding to $8.4\times 10^{10}$ electrons on target (EOT) in 2017 and 2018. In order to increase sensitivity to small coupling parameter $\epsilon$ we used also the data collected in 2016 - 2018 in the "invisible mode" configuration of NA64 with a total statistics corresponding to $2.84\times 10^{11}$ EOT. A thorough analysis of both these data samples in the sense of background and efficiency estimations was already performed and reported in our previous papers devoted to the search for light vector particles and axion-like particles (ALP). In this work we recalculate the signal yields, which are different due to different cross section and life time of a pseudoscalar particle $a$, and perform a new statistical analysis. As a result, the region of the two dimensional parameter space $m_a - \epsilon$ in the mass range from 1 to 17.1 MeV is excluded. At the mass of the ATOMKI anomaly the values of $\epsilon$ in the range $2.1 \times 10^{-4} < \epsilon < 3.2 \times 10^{-4}$ are excluded.

Over the last decade, an important challenge in nanomedicine imaging has been the work to design multifunctional agents that can be detected by single and/or multimodal techniques. Among the broad spectrum of nanoscale materials being investigated for imaging use, iron oxide nanoparticles have gained significant attention due to their intrinsic magnetic properties, low toxicity, large magnetic moments, superparamagnetic behaviour and large surface area—the latter being a particular advantage in its conjunction with specific moieties, dye molecules, and imaging probes. Tracers-based nanoparticles are promising candidates, since they combine synergistic advantages for non-invasive, highly sensitive, high-resolution, and quantitative imaging on different modalities. This study represents an overview of current advancements in magnetic materials with clinical potential that will hopefully provide an effective system for diagnosis in the near future. Further exploration is still needed to reveal their potential as promising candidates from simple functionalization of metal oxide nanomaterials up to medical imaging., info:eu-repo/semantics/published

We present results of the Relic Axion Dark-Matter Exploratory Setup (RADES), a detector which is part of the CERN Axion Solar Telescope (CAST), searching for axion dark matter in the 34.67μeV mass range. A radio frequency cavity consisting of 5 sub-cavities coupled by inductive irises took physics data inside the CAST dipole magnet for the first time using this filter-like haloscope geometry. An exclusion limit with a 95% credibility level on the axion-photon coupling constant of gaγ & 4 × 10−13 GeV−1 over a mass range of 34.6738μeV < ma < 34.6771μeV is set. This constitutes a significant improvement over the current strongest limit set by CAST at this mass and is at the same time one of the most sensitive direct searches for an axion dark matter candidate above the mass of 25μeV. The results also demonstrate the feasibility of exploring a wider mass range around the value probed by CAST-RADES in this work using similar coherent resonant cavities We wish to thank our colleagues at CERN, in particular Marc Thiebert from the coating lab, as well as the whole team of the CERN Central Cryogenic Laboratory for their support and advice in speci c aspects of the project. We thank Arefe Abghari for her contributions as the project's summer student during 2018. This work has been funded by the Spanish Agencia Estatal de Investigacion (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) under project FPA-2016-76978-C3-2-P and PID2019-108122GB-C33, and was supported by the CERN Doctoral Studentship programme. The research leading to these results has received funding from the European Research Council and BD, JG and SAC acknowledge support through the European Research Council under grant ERC-2018-StG-802836 (AxScale project). BD also acknowledges fruitful discussions at MIAPP supported by DFG under EXC-2094 { 390783311. IGI acknowledges also support from the European Research Council (ERC) under grant ERC-2017-AdG-788781 (IAXO+ project). JR has been supported by the Ramon y Cajal Fellowship 2012-10597, the grant PGC2018-095328-B-I00(FEDER/Agencia estatal de investigaci on) and FSE-GA2017-2019-E12/7R (Gobierno de Aragón/FEDER) (MINECO/FEDER), the EU through the ITN \Elusives" H2020-MSCA-ITN-2015/674896 and the Deutsche Forschungsgemeinschaft under grant SFB-1258 as a Mercator Fellow. CPG was supported by PROMETEO II/2014/050 of Generalitat Valenciana, FPA2014-57816-P of MINECO and by the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreements 690575 and 674896. AM is supported by the European Research Council under Grant No. 742104. Part of this work was performed under the auspices of the US Department of Energy by Lawrence Livermore National Laboratory under Contract No. DE-AC52-07NA27344.

Dark matter (DM) comes from long-range gravitational observations, and it is considered as something that does not interact with ordinary matter or emits light. However, also on much smaller scales, a number of unexpected observations of the solar activity and the dynamic Earth atmosphere might arise from DM contradicting the aforementioned DM picture. Because, gravitational (self) focusing effects by the Sun or its planets of streaming DM fit as the interpretation of the otherwise puzzling 11-year solar cycle, the mysterious heating of the solar corona, atmospheric transients, etc. Observationally driven, an external impact by overlooked streaming invisible matter reconciles the investigated mysterious behavior showing otherwise unexpected planetary relationships; this is a signature for gravitational focusing of streaming DM by the solar system bodies. Then, focusing of DM streams could also occur in exoplanetary systems, suggesting for the first time the carrying out of investigations by searching for the associated stellar activity as a function of the exoplanetary orbital phases., 7 pages, 2 figures, Presented at the first Electronic Conference on Universe, February 2021

We performed a search for a new generic X boson, which could be a scalar (S), pseudoscalar (P), vector (V), or an axial vector (A) particle produced in the 100 GeV electron scattering off nuclei, e−Z→e−ZX, followed by its invisible decay in the NA64 experiment at CERN. No evidence for such a process was found in the full NA64 dataset of 2.84×1011 electrons on target. We place new bounds on the S, P, V, A coupling strengths to electrons, and set constraints on their contributions to the electron anomalous magnetic moment ae, |ΔaX|≲10−15–10−13 for the X mass region 1 MeV≲mX≲1 GeV. These results are an order of magnitude more sensitive compared to the current accuracy on ae from the electron g−2 experiments and recent high-precision determination of the fine structure constant.

We report the results of a search for a light pseudoscalar particle a that couples to electrons and decays to e+e- performed using the high-energy CERN SPS H4 electron beam. If such light pseudoscalar exists, it could explain the ATOMKI anomaly (an excess of e+e- pairs in the nuclear transitions of Be8 and He4 nuclei at the invariant mass ≃17 MeV observed by the experiment at the 5 MV Van de Graaff accelerator at ATOMKI, Hungary). We used the NA64 data collected in the "visible mode"configuration with a total statistics corresponding to 8.4×1010 electrons on target (EOT) in 2017 and 2018. In order to increase sensitivity to small coupling parameter ϵ we also used the data collected in 2016-2018 in the "invisible mode"configuration of NA64 with a total statistics corresponding to 2.84×1011 EOT. The background and efficiency estimates for these two configurations were retained from our previous analyses searching for light vector bosons and axionlike particles (ALP) (the latter were assumed to couple predominantly to γ). In this work we recalculate the signal yields, which are different due to different cross section and lifetime of a pseudoscalar particle a, and perform a new statistical analysis. As a result, the region of the two dimensional parameter space ma-ϵ in the mass range from 1 to 17.1 MeV is excluded. At the mass of the central value of the ATOMKI anomaly (the first result obtained on the beryllium nucleus, 16.7 MeV) the values of ϵ in the range 2.1×10-4, Physical Review D, 104 (11), ISSN:1550-7998, ISSN:0556-2821, ISSN:1550-2368

The current most stringent constraints for the existence of sub-GeV dark matter coupling to Standard Model via a massive vector boson $A^\prime$ were set by the NA64 experiment for the mass region $m_{A^\prime}\lesssim 250$ MeV, by analyzing data from the interaction of $2.84\cdot10^{11}$ 100-GeV electrons with an active thick target and searching for missing-energy events. In this work, by including $A^\prime$ production via secondary positron annihilation with atomic electrons, we extend these limits in the $200$-$300$ MeV region by almost an order of magnitude, touching for the first time the dark matter relic density constrained parameter combinations. Our new results demonstrate the power of the resonant annihilation process in missing energy dark-matter searches, paving the road to future dedicated $e^+$ beam efforts., Comment: Version accepted for publication as a Letter in Phys. Rev. D

We present results of the Relic Axion Dark-Matter Exploratory Setup (RADES), a detector which is part of the CERN Axion Solar Telescope (CAST), searching for axion dark matter in the 34.67$��$eV mass range. A radio frequency cavity consisting of 5 sub-cavities coupled by inductive irises took physics data inside the CAST dipole magnet for the first time using this filter-like haloscope geometry. An exclusion limit with a 95% credibility level on the axion-photon coupling constant of g$_{a��}\gtrsim 4\times10^{-13} \text{GeV}^{-1}$ over a mass range of 34.6738 $��$eV < $m_a$ < 34.6771 $��$eV is set. This constitutes a significant improvement over the current strongest limit set by CAST at this mass and is at the same time one of the most sensitive direct searches for an axion dark matter candidate above the mass of 25 $��$eV. The results also demonstrate the feasibility of exploring a wider mass range around the value probed by CAST-RADES in this work using similar coherent resonant cavities., 14 pages, 9 figures. Accepted for publication in JHEP. Minor changes done compared to the previous version

Photos have been used as evident material in news reporting almost since the beginning of Journalism. In this context, manipulated or tampered pictures are very common as part of informing articles, in today's misinformation crisis. The current paper investigates the ability of people to distinguish real from fake images. The presented data derive from two studies. Firstly, an online cross-sectional survey (N = 120) was conducted to analyze ordinary human skills in recognizing forgery attacks. The target was to evaluate individuals' perception in identifying manipulated visual content, therefore, to investigate the feasibility of “crowdsourced validation”. This last term refers to the process of gathering fact-checking feedback from multiple users, thus collaborating towards assembling pieces of evidence on an event. Secondly, given that contemporary veracity solutions are coupled with both journalistic principles and technology developments, an experiment in two phases was employed: a) A repeated measures experiment was conducted to quantify the associated abilities of Media and Image Experts (N = 5 + 5) in detecting tampering artifacts. In this latter case, image verification algorithms were put into the core of the analysis procedure to examine their impact on the authenticity assessment task. b) Apart from conducting interview sessions with the selected experts and their proper guidance in using the tools, a second experiment was also deployed on a larger scale through an online survey (N = 301), aiming at validating some of the initial findings. The primary intent of the deployed analysis and their combined interpretation was to evaluate image forensic services, offered as real-world tools, regarding their comprehension and utilization by ordinary people, involved in the everyday battle against misinformation. The outcomes confirmed the suspicion that only a few subjects had prior knowledge of the implicated algorithmic solutions. Although these assistive tools often lead to controversial or even contradictory conclusions, their experimental treatment with the systematic training in their proper use boosted the participants' performance. Overall, the research findings indicate that the scores of successful detections, relying exclusively on human observations, cannot be disregarded. Hence, the ultimate challenge for the “verification industry” should be to balance between forensic automations and the human experience, aiming at defending the audience from inaccurate information propagation., Content authentication; digital forensics; image tampering; misinformation, verification assistance algorithms

We report on a first measurement with a sensitive opto-mechanical force sensor designed for the direct detection of coupling of real chameleons to matter. These dark energy candidates could be produced in the Sun and stream unimpeded to Earth. The KWISP detector installed on the CAST axion search experiment at CERN looks for tiny displacements of a thin membrane caused by the mechanical effect of solar chameleons. The displacements are detected by a Michelson interferometer with a homodyne readout scheme. The sensor benefits from the focusing action of the ABRIXAS X-ray telescope installed at CAST, which increases the chameleon flux on the membrane. A mechanical chopper placed between the telescope output and the detector modulates the incoming chameleon stream. We present the results of the solar chameleon measurements taken at CAST in July 2017, setting an upper bound on the force acting on the membrane of $80$~pN at 95\% confidence level. The detector is sensitive for direct coupling to matter $10^4 \leq\beta_m \leq 10^8$, where the coupling to photons is locally bound to $\beta_\gamma \leq 10^{11}$., Comment: 21 pages, 12 figures

Aim Increased emphasis is on using tissue substitutes and stem cells to improve flap applicability and survival rates. To accomplish this, the first step is to have a versatile experimental flap, easy to harvest and use as a template. We sought to develop a reliable experimental chimeric groin flap with free mobility and reliable bloods supply that can be twisted, relocated, and integrated easily with other materials. Materials and methods Ten male Wistar rats were included. The flap consists of a 2.5-cm skin paddle centered on the medial branch of the inferior epigastric artery and a 4.5/2-cm fat pad supplied by the lateral branch of the inferior epigastric artery. After being raised, flaps were resutured in their anatomical position. Flaps were followed up for 15 days. At the end of the study, the viability of flaps was analyzed by ultrahigh-frequency ultrasound, nontargeted contrast study, and histology assessment. Results All flaps survived without significant complications. Nontargeted microbubbles spread evenly in both the superficial and deep flap. Ultrasound assessment at day 15 showed no significant areas of necrosis or edema. Histology examination of 3 random flaps confirmed vessel patency and flap viability. Conclusion We propose a simple, easy to harvest and reliable experimental flap which offers a main advantage of all-around mobility through its chimeric design. It is a suitable model for bioengineering studies as it can be used as a template for integration of tissue substitutes or stem cells, between its 2 components.

The improved results on a direct search for a new X ( 16.7 MeV ) boson that could explain the anomalous excess of e + e − pairs observed in the decays of the excited 8 Be ∗ nuclei (“Berillium or X17 anomaly”) are reported. Interestingly, new recent results in the nuclear transitions of another nucleus, 4 He , seems to support this anomaly spurring the need for an independent measurement. If the X boson exists, it could be produced in the bremsstrahlung reaction e − Z → e − Z X by a high energy beam of electrons incident on the active target in the NA64 experiment at the CERN Super Proton Synchrotron and observed through its subsequent decay into e + e − pairs. No evidence for such decays was found from the combined analysis of the data samples with total statistics corresponding to 8.4 × 10 10 electrons on target collected in 2017 and 2018. This allows one to set new limits on the X − e − coupling in the range 1.2 × 10 − 4 ≲ e e ≲ 6.8 × 10 − 4 , excluding part of the parameter space favored by the X17 anomaly, and setting new bounds on the mixing strength of photons with dark photons ( A ′ ) with a mass ≲ 24 MeV . For the 2018 run, the setup was optimized to probe the region of parameter space characterized by a large coupling e . This allowed a significant improvement in sensitivity despite a relatively modest increase in statistics.

The MAgnetized Disk and Mirror Axion eXperiment (MADMAX) is a new initiative to search for dark matter axions in the mass range of 40 to 400 μeV. The MADMAX collaboration is presently preparing its prototype booster to validate the experimental concept by proving the mechanical feasibility. Here we propose to use the MORPURGO magnet at CERN during SPS shutdown periods to demonstrate the mechanical feasibility of the concept in an external static B-field. Additionally, the MORPURGO magnet would be used to perform a first competitive search for ALPs in a so far unexplored parameter range.

The MAgnetized Disk and Mirror Axion eXperiment (MADMAX) is a new initiative to search for dark matter axions in the mass range of 40 to 400 $\mu$eV. The MADMAX collaboration is presently preparing its prototype booster to validate the experimental concept by proving the mechanical feasibility. Here we propose to use the MORPURGO magnet at CERN during SPS shutdown periods to demonstrate the mechanical feasibility of the concept in an external static B-field. Additionally, the MORPURGO magnet would be used to perform a first competitive search for ALPs in a so far unexplored parameter range.

Recently, the ATOMKI experiment has reported new evidence for the excess of e+e- events with a mass ∼ 17 MeV in the nuclear transitions of 4He, that they previously observed in measurements with 8Be. These observations could be explained by the existence of a new vector X17 boson. So far, the search for the decay X17 → e+e- with the NA64 experiment at the CERN SPS gave negative results. Here, we present a new technique that could be implemented in NA64 aiming to improve the sensitivity and to cover the remaining X17 parameter space. If a signal-like event is detected, an unambiguous observation is achieved by reconstructing the invariant mass of the X17 decay with the proposed method. To reach this goal an optimization of the X17 production target, as well as an efficient and accurate reconstruction of two close decay tracks, is required. A dedicated analysis of the available experimental data making use of the trackers information is presented. This method provides independent confirmation of the NA64 published results [1], validating the tracking procedure. The detailed Monte Carlo study of the proposed setup and the background estimate show that the goal of the proposed search is feasible., The European Physical Journal C, 80 (12), ISSN:1434-6044, ISSN:1434-6052