Search

The co-evolution of galaxies and supermassive black holes (SMBHs) underpins our understanding of galaxy evolution, but different methods to measure SMBH masses have only infrequently been cross-checked. We attempt to identify targets to cross-check two of the most accurate methods, megamaser and cold molecular gas dynamics. Three promising galaxies are selected from all those with existing megamaser SMBH mass measurements. We present Atacama Large Millimeter/sub-millimeter Array (ALMA) 12CO(2-1) and 230-GHz continuum observations with angular resolutions of about 0.5". Every galaxy has an extended rotating molecular gas disc and 230-GHz continuum source(s), but all also have irregularities and/or non-axisymmetric features: NGC1194 is highly inclined and has disturbed and lopsided central 12CO(2-1) emission; NGC3393 has a nuclear disc with fairly regular but patchy 12CO(2-1) emission with little gas near the kinematic major axis, faint emission in the very centre and two brighter structures reminiscent of a nuclear ring and/or spiral; NGC5765B has a strong bar and very bright 12CO(2-1) emission concentrated along two bisymmetric offset dust lanes and two bisymmetric nuclear spiral arms. 12CO(2-1) and 12CO(3-2) observations with the James Clerk Maxwell Telescope are compared with the ALMA observations. Because of the disturbed gas kinematics and the impractically long integration times required for higher angular resolution observations, none of the three galaxies is suitable for a future SMBH mass measurement. Nonetheless, increasing the number of molecular gas observations of megamaser galaxies is valuable, and the ubiquitous disturbances suggest a link between large-scale gas properties and the existence of megamasers., Comment: 17 pages, 5 figures, accepted by MNRAS

Machine learning has recently achieved remarkable success in studying phase transitions. It is generally believed that the latent variables of unsupervised learning can capture the information related to phase transitions, which is usually achieved through the so-called order parameter. In most models, for instance the Ising, the order parameters are simply the particle number densities. The percolation, the simplest model which can generate a phase transition, however, has a unique order parameter which is not particle number density. In this paper, we use unsupervised learning to study the relationship between particle number density, critical point, and latent variables in the site percolation model. It is found that if the input of learning is the original configuration, then the output of unsupervised learning does not convey any information related to the phase transition. Therefore, the maximum cluster is employed in order to effectively capture the critical point of the model. Unsupervised learning yields reliable results consistent with Monte Carlo simulations. We also propose a method called Fake Finite Size Scaling (FFSS) to calculate the critical value, which improves the accuracy of fitting to a great extent., Comment: 12 pages,27 figures,45 references

In recent years, the field of metal-halide perovskite emitters has rapidly emerged as a new community in solid-state lighting. Their exceptional optoelectronic properties have contributed to the rapid rise in external quantum efficiencies (EQEs) in perovskite light-emitting diodes (PeLEDs) from <1% (in 2014) to approaching 30% (in 2023) across a wide range of wavelengths. However, several challenges still hinder their commercialization, including the relatively low EQEs of blue/white devices, limited EQEs in large-area devices, poor device stability, as well as the toxicity of the easily accessible lead components and the solvents used in the synthesis and processing of PeLEDs. This roadmap addresses the current and future challenges in PeLEDs across fundamental and applied research areas, by sharing the community's perspectives. This work will provide the field with practical guidelines to advance PeLED development and facilitate more rapid commercialization., Comment: 103 pages, 29 figures. This is the version of the article before peer review or editing, as submitted by an author to Journal of Physics: Photonics. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it

In the past decade, photonic integrated circuits (PICs) based on thin-film lithium niobate (TFLN) have advanced in various fields, including optical communication, nonlinear photonics, and quantum optics. A critical component is an efficient edge coupler connecting PICs to light sources or detectors. Here, we propose an innovative edge coupler design with a wedge-shaped TFLN waveguide and a silicon oxynitride (SiON) cladding. Experimental results show that the coupling loss between the TFLN PIC and a 3-{\mu}m mode field diameter (MFD) lensed fiber is low at 1.52 dB/facet, with the potential for improvement to 0.43 dB/facet theoretically. The coupling loss between the edge coupler and a UHNA7 fiber with an MFD of 3.2 {\mu}m is reduced to 0.92 dB/facet. This design maintains robust fabrication and alignment tolerance. Importantly, the minimum linewidth of the TFLN waveguide of the coupler (600 nm) can be easily achieved using foundry-available i-line stepper lithography. This work benefits the development of TFLN integrated platforms, such as on-chip electro-optic modulators, frequency comb generation, and quantum sensors.

Masked image modeling (MIM) is a highly popular and effective self-supervised learning method for image understanding. Existing MIM-based methods mostly focus on spatial feature modeling, neglecting spectral feature modeling. Meanwhile, existing MIM-based methods use Transformer for feature extraction, some local or high-frequency information may get lost. To this end, we propose a spatial-spectral masked auto-encoder (SS-MAE) for HSI and LiDAR/SAR data joint classification. Specifically, SS-MAE consists of a spatial-wise branch and a spectral-wise branch. The spatial-wise branch masks random patches and reconstructs missing pixels, while the spectral-wise branch masks random spectral channels and reconstructs missing channels. Our SS-MAE fully exploits the spatial and spectral representations of the input data. Furthermore, to complement local features in the training stage, we add two lightweight CNNs for feature extraction. Both global and local features are taken into account for feature modeling. To demonstrate the effectiveness of the proposed SS-MAE, we conduct extensive experiments on three publicly available datasets. Extensive experiments on three multi-source datasets verify the superiority of our SS-MAE compared with several state-of-the-art baselines. The source codes are available at \url{https://github.com/summitgao/SS-MAE}., Comment: IEEE TGRS 2023

The peptide-like molecules, cyanoformamide (NCCONH2), is the cyano (CN) derivative of formamide (NH2CHO). It is known to play a role in the synthesis of nucleic acid precursors under prebiotic conditions. In this paper, we present a tentative detection of NCCONH2 in the interstellar medium (ISM) with the Atacama Large Millimeter/submillimeter Array (ALMA) archive data. Ten unblended lines of NCCONH2 were seen around 3sigma noise levels toward Sagittarius B2(N1E), a position that is slightly offset from the continuum peak. The column density of NCCONH2 was estimated to be 2.4\times 10^15 cm ^-2, and the fractional abundance of NCCONH2 toward Sgr B2(N1E) was 6.9\times10^-10. The abundance ratio between NCCONH2 and NH2CHO is estimated to be ~0.01. We also searched for other peptide-like molecules toward Sgr B2(N1E). The abundances of NH2CHO, CH3NCO and CH3NHCHO toward Sgr B2(N1E) were about one tenth of those toward Sgr B2(N1S), while the abundances of CH3CONH2 was only one twentieth of that toward Sgr B2(N1S)., Comment: 20 pages, 6 figures, 2 tables, accepted by PASJ

The isotopic ratios are good tools for probing the stellar nucleosynthesis and chemical evolution. We performed high-sensitivity mapping observations of the J=7-6 rotational transitions of OCS, OC34S, O13CS, and OC33S toward the Galactic Center giant molecular cloud, Sagittarius B2 (Sgr B2) with IRAM 30m telescope. Positions with optically thin and uncontaminated lines are chosen to determine the sulfur isotope ratios. A 32S/34S ratio of 17.1\pm0.9 was derived with OCS and OC34S lines, while 34S/33S ratio of 6.8\pm1.9 was derived directly from integrated intensity ratio of OC34S and OC33S. With independent and accurate measurements of 32S/34S ratio, our results confirm the termination of the decreasing trend of 32S/34S ratios toward the Galactic Center, suggesting a drop in the production of massive stars at the Galactic centre., Comment: 20 pages, 7 figures, accepted by PASJ

Peptide-like molecule, which has a close connection with the origin of life, has been detected in universe. Mapping observations of HCONH$_2$ and CH$_3$CONH$_2$, two simplest peptide-like molecules, are performed towards Sagittarius B2 (Sgr B2) complex with the IRAM 30m telescope. Seven transitions of HCONH$_2$ and five transitions of CH$_3$CONH$_2$ are used in analysis. The spatial distribution of excitation temperature and column density of HCONH$_2$ in the molecular envelope of Sgr B2 are obtained by the rotation diagrams. Assuming the same excitation temperature as HCONH$_2$, the column densities of CH$_3$CONH$_2$ are also calculated. The results show that excitation temperature ranges from 6 K to 46 K in the molecular envelope of Sgr B2. The abundance ratio between HCONH$_2$ and CH$_3$CONH$_2$ are calculated to explore the relationship among them, as well as HNCO mentioned in our pervious research. The abundance ratio of CH$_3$CONH$_2$/HCONH$_2$ varies from 10% to 20%, while that of HCONH$_2$/HNCO ranges from 1.5% to 10%. CH$_3$CONH$_2$ is enhanced with respect to HCONH$_2$ in the northwest region of Sgr B2. One transition of H$^{13}$CONH$_2$ is detected toward 12 positions of Sgr B2, from which a $^{12}$C/$^{13}$C ratio of 28.7 is obtained. A time-dependent chemical model with a short duration of X-ray burst is used to explain the observed abundances of HCONH$_2$ and CH$_3$CONH$_2$, with the best fitting result at T$\rm_{dust}$ = 53-56 K. More chemical reactions are required to be included into the model since the modeled abundance is lower than the observed one at the observed T$\rm_{dust}$.

DEtection TRansformer (DETR) and its variants (DETRs) have been successfully applied to crowded pedestrian detection, which achieved promising performance. However, we find that, in different degrees of crowded scenes, the number of DETRs' queries must be adjusted manually, otherwise, the performance would degrade to varying degrees. In this paper, we first analyze the two current query generation methods and summarize four guidelines for designing the adaptive query generation method. Then, we propose Rank-based Adaptive Query Generation (RAQG) to alleviate the problem. Specifically, we design a rank prediction head that can predict the rank of the lowest confidence positive training sample produced by the encoder. Based on the predicted rank, we design an adaptive selection method that can adaptively select coarse detection results produced by the encoder to generate queries. Moreover, to train the rank prediction head better, we propose Soft Gradient L1 Loss. The gradient of Soft Gradient L1 Loss is continuous, which can describe the relationship between the loss value and the updated value of model parameters granularly. Our method is simple and effective, which can be plugged into any DETRs to make it query-adaptive in theory. The experimental results on Crowdhuman dataset and Citypersons dataset show that our method can adaptively generate queries for DETRs and achieve competitive results. Especially, our method achieves state-of-the-art 39.4% MR on Crowdhuman dataset., Comment: 10 pages, 6 figures

The model discussion focused on links between the unique properties of relaxor ceramics and the basics of critical phenomena physics and glass transition physics. It indicates the significance of uniaxiality for appearing mean-field features near paraelectric_ferroelectric transition. Pretransitional fluctuations, increasing up to grain size and leading to inter-grain, random, local electric fields, are indicated to be responsible for relaxor ceramics characteristics. Their impacts yield the pseudo spinodal behavior associated with weakly discontinuous local phase transitions. The emerging model redefines the meaning of the Burns temperature and polar nanoregions PNRs. It explains coherently dielectric constant changes with the diffused maximum near paraelectric_ferroelectric transition, the sensitivity even to moderate electric fields, tunability, and the glassy dynamics. These considerations are confronted with experimental results for the complex dielectric permittivity studies in relaxor ceramic, covering the 200K range, from the paraelectric to the deep ferroelectric phase. The distortions-sensitive and derivative-based analysis revealed the preference for the exponential scaling pattern in the paraelectric phase and the surroundings of the paraelectric-ferroelectric transition. It may suggest the Griffith phase behavior associated with the mean-field criticality disturbed by random local impacts. The discussion of experimental results is supplemented by relaxation times changes and the coupled energy losses analysis. The studies also led to the description of tunability temperature changes with scaling relations., Comment: 39 PAGES, 20 Figures

In this work, we introduce OmniDrones, an efficient and flexible platform tailored for reinforcement learning in drone control, built on Nvidia's Omniverse Isaac Sim. It employs a bottom-up design approach that allows users to easily design and experiment with various application scenarios on top of GPU-parallelized simulations. It also offers a range of benchmark tasks, presenting challenges ranging from single-drone hovering to over-actuated system tracking. In summary, we propose an open-sourced drone simulation platform, equipped with an extensive suite of tools for drone learning. It includes 4 drone models, 5 sensor modalities, 4 control modes, over 10 benchmark tasks, and a selection of widely used RL baselines. To showcase the capabilities of OmniDrones and to support future research, we also provide preliminary results on these benchmark tasks. We hope this platform will encourage further studies on applying RL to practical drone systems., Comment: Submitted to IEEE RA-L

Synthetic aperture radar (SAR) image change detection is a critical task and has received increasing attentions in the remote sensing community. However, existing SAR change detection methods are mainly based on convolutional neural networks (CNNs), with limited consideration of global attention mechanism. In this letter, we explore Transformer-like architecture for SAR change detection to incorporate global attention. To this end, we propose a convolution and attention mixer (CAMixer). First, to compensate the inductive bias for Transformer, we combine self-attention with shift convolution in a parallel way. The parallel design effectively captures the global semantic information via the self-attention and performs local feature extraction through shift convolution simultaneously. Second, we adopt a gating mechanism in the feed-forward network to enhance the non-linear feature transformation. The gating mechanism is formulated as the element-wise multiplication of two parallel linear layers. Important features can be highlighted, leading to high-quality representations against speckle noise. Extensive experiments conducted on three SAR datasets verify the superior performance of the proposed CAMixer. The source codes will be publicly available at https://github.com/summitgao/CAMixer ., Comment: Accepted by IEEE GRSL

The core-collapse supernova (CCSN) is considered one of the most energetic astrophysical events in the universe. The early and prompt detection of neutrinos before (pre-SN) and during the supernova (SN) burst presents a unique opportunity for multi-messenger observations of CCSN events. In this study, we describe the monitoring concept and present the sensitivity of the system to pre-SN and SN neutrinos at the Jiangmen Underground Neutrino Observatory (JUNO), a 20 kton liquid scintillator detector currently under construction in South China. The real-time monitoring system is designed to ensure both prompt alert speed and comprehensive coverage of progenitor stars. It incorporates prompt monitors on the electronic board as well as online monitors at the data acquisition stage. Assuming a false alert rate of 1 per year, this monitoring system exhibits sensitivity to pre-SN neutrinos up to a distance of approximately 1.6 (0.9) kiloparsecs and SN neutrinos up to about 370 (360) kiloparsecs for a progenitor mass of 30 solar masses, considering both normal and inverted mass ordering scenarios. The pointing ability of the CCSN is evaluated by analyzing the accumulated event anisotropy of inverse beta decay interactions from pre-SN or SN neutrinos. This, along with the early alert, can play a crucial role in facilitating follow-up multi-messenger observations of the next galactic or nearby extragalactic CCSN., Comment: 24 pages, 9 figures, accepted for the publication at JCAP

Cerebrovascular disease is one of the major diseases facing the world today. Automatic segmentation of intracranial artery (IA) in digital subtraction angiography (DSA) sequences is an important step in the diagnosis of vascular related diseases and in guiding neurointerventional procedures. While, a single image can only show part of the IA within the contrast medium according to the imaging principle of DSA technology. Therefore, 2D DSA segmentation methods are unable to capture the complete IA information and treatment of cerebrovascular diseases. We propose A timing sequence image segmentation network with U-shape, called TSI-Net, which incorporates a bi-directional ConvGRU module (BCM) in the encoder. The network incorporates a bi-directional ConvGRU module (BCM) in the encoder, which can input variable-length DSA sequences, retain past and future information, segment them into 2D images. In addition, we introduce a sensitive detail branch (SDB) at the end for supervising fine vessels. Experimented on the DSA sequence dataset DIAS, the method performs significantly better than state-of-the-art networks in recent years. In particular, it achieves a Sen evaluation metric of 0.797, which is a 3% improvement compared to other methods.

Photoacoustic imaging (PAI) is a novel modality in biomedical imaging technology that combines the rich optical contrast with the deep penetration of ultrasound. To date, PAI technology has found applications in various biomedical fields. In this review, we present an overview of the emerging research frontiers on PAI plus other advanced technologies, named as PAI plus X, which includes but not limited to PAI plus treatment, PAI plus new circuits design, PAI plus accurate positioning system, PAI plus fast scanning systems, PAI plus novel ultrasound sensors, PAI plus advanced laser sources, PAI plus deep learning, and PAI plus other imaging modalities. We will discuss each technology's current state, technical advantages, and prospects for application, reported mostly in recent three years. Lastly, we discuss and summarize the challenges and potential future work in PAI plus X area.

Shearing test is carried out on the joint which bonded under different pre curing processes with two component adhesives of acrylic and epoxy resin respectively. The pre curing strength is obtained, which used to analyze the relationship between the pre curing strength and time. The hoods with different pre curing strength are baking with high temperature. The deformation of different areas of the hood is measured with gauges, and the deformation characteristics of the hood after baking are acquired with comparative analysis. Combining the components of two component adhesives and DSC test, the pre curing mechanism of different adhesive systems are studied. Therefore, the key factors and regular pattern of the deformation for the hood are obtained. The results indicate that, finally deformation of the hood after high temperature baking varies with the pre curing time. The key of the pre curing time of acrylic adhesives lies in the chain initiation stage of the free radical polymerization reaction. Due to the influence of the chemical properties of methyl acrylate and its initiator, the pre curing reaction induced by free radical polymerization is very fast. The shear strength of this joint can reach to 3.67 MPa with a pre curing time of 1 h, which quickly achieving the pre cure strength required for deformation control. For epoxy adhesives, the rate determining step in pre curing process is the esterification reaction. Due to the influence of the structure of carboxylic acid, the esterification process is relatively long. Shear strength of this joint can only reach 0.87 MPa after pre curing for 4 h without external heating., Comment: 16 pages,8 figures,3 tables

In the modern financial industry system, the structure of products has become more and more complex, and the bottleneck constraint of classical computing power has already restricted the development of the financial industry. Here, we present a photonic chip that implements the unary approach to European option pricing, in combination with the quantum amplitude estimation algorithm, to achieve a quadratic speedup compared to classical Monte Carlo methods. The circuit consists of three modules: a module loading the distribution of asset prices, a module computing the expected payoff, and a module performing the quantum amplitude estimation algorithm to introduce speed-ups. In the distribution module, a generative adversarial network is embedded for efficient learning and loading of asset distributions, which precisely capture the market trends. This work is a step forward in the development of specialized photonic processors for applications in finance, with the potential to improve the efficiency and quality of financial services., Comment: 11 pages, 7 figures

We theoretically study the effect of quantum statistics of the light field on the quantum enhancement of parameter estimation based on cat state input the SU(1,1) interferometer. The phase sensitivity is dependent on the relative phase $\theta$ between two coherent states of Schr\"{o}dinger cat states. The optimal sensitivity is achieved when the relative phase is $\pi$% , i.e., odd coherent states input. For a coherent state input into one port, the phase sensitivity of the odd coherent state into the second input port is inferior to that of the squeezed vacuum state input. However, in the presence of losses the Schr\"{o}dinger cat states are more resistant to loss than squeezed vacuum states. As the amplitude of Schr\"{o}dinger cat states increases, the quantum enhancement of phase sensitivity decreases, which shows that the quantum statistics of Schr\"{o}dinger cat states tends towards Poisson statistics from sub-Poisson statistics or super-Poisson statistics., Comment: 8 pages, 5 figures. arXiv admin note: text overlap with arXiv:2302.09823

Cell proliferation and migration highly relate to normal tissue self-healing, therefore it is highly significant for artificial controlling. Recently, vibrational strong coupling between biomolecules and Mid-infrared (MIR) light photons has been successfully used to modify in vitro bioreactions, neuronal signaling and even animal behavior. However, the synergistic effects from molecules to cells remains unclear, and the regulation of MIR on cells needs to be explained from the molecular level. Herein, the proliferation rate and migration capacity of fibroblasts were increased by 156% and 162.5%, respectively, by vibratory coupling of 5.6 micrometers photons with carbonyl groups in biomolecules. Through transcriptome sequencing analysis, the regulatory mechanism of infrared light in 5.6 micrometers was explained from the level of signal pathway and cell components. 5.6 micrometers optical high power lasers can regulate cell function through vibrational strong coupling while minimizing photothermal damage. This work not only sheds light on the non-thermal effect on MIR light-based on wound healing, but also provides new evidence to future frequency medicine., Comment: 20 pages, 5 figures

The dimensions of liquid scintillator neutrino detectors have grown over the years. Thus, the analog cable length required for the readout increases. In consequence, the signal loss increases as well. With the intelligent Photomultiplier Tube this problem can be solved. The digitiser is moved as close as possible to the Photomultiplier Tube. This concept allows nearly lossless digitisation of the analog signal. Furthermore, a computing unit next to the analog-to-digital converter enables implementation of on-the-fly data processing and control algorithms. This paper presents the detailed concept and the performance of the intelligent Photomultiplier Tube., Comment: to be published in JINST

Recently, learned image compression has achieved impressive performance. The entropy model, which estimates the distribution of the latent representation, plays a crucial role in enhancing rate-distortion performance. However, existing global context modules rely on computationally intensive quadratic complexity computations to capture global correlations. This quadratic complexity imposes limitations on the potential of high-resolution image coding. Moreover, effectively capturing local, global, and channel-wise contexts with acceptable even linear complexity within a single entropy model remains a challenge. To address these limitations, we propose the Linear Complexity Multi-Reference Entropy Model (MEM++). MEM++ effectively captures the diverse range of correlations inherent in the latent representation. Specifically, the latent representation is first divided into multiple slices. When compressing a particular slice, the previously compressed slices serve as its channel-wise contexts. To capture local contexts without sacrificing performance, we introduce a novel checkerboard attention module. Additionally, to capture global contexts, we propose the linear complexity attention-based global correlations capturing by leveraging the decomposition of the softmax operation. The attention map of the previously decoded slice is implicitly computed and employed to predict global correlations in the current slice. Based on MEM++, we propose image compression model MLIC++. Extensive experimental evaluations demonstrate that our MLIC++ achieves state-of-the-art performance, reducing BD-rate by 13.39% on the Kodak dataset compared to VTM-17.0 in PSNR. Furthermore, MLIC++ exhibits linear GPU memory consumption with resolution, making it highly suitable for high-resolution image coding. Code and pre-trained models are available at https://github.com/JiangWeibeta/MLIC., Comment: Compared with version presented at Neural Compression Workshop, ICML 2023 at OpenReview, in this arxiv version, we add the details of our prior work presented at ACMMM 2023, new comparisons on complexity, and more ablation studies

Photoacoustic imaging (PAI) has been applied to many biomedical applications over the past decades. However, the received PA signal usually suffers from poor signal-to-noise ratio (SNR). Conventional solution of employing higher-power laser, or doing long-time signal averaging, may raise the system cost, time consumption, and tissue damage. Another strategy is de-noising algorithm design. In this paper, we propose a new de-noising method, termed gradient-based adaptive wavelet de-noising, which sets the energy gradient mutation point of low-frequency wavelet components as the threshold. We conducted simulation, ex vivo and in vivo experiments to validate the performance of the algorithm. The quality of de-noised PA image/signal by our proposed algorithm has improved by 20%-40%, in comparison to the traditional signal denoising algorithms, which produces better contrast and clearer details. The proposed de-noising method provides potential to improve the SNR of PA signal under single-shot low-power laser illumination for biomedical applications in vivo.

Human motion generation aims to generate natural human pose sequences and shows immense potential for real-world applications. Substantial progress has been made recently in motion data collection technologies and generation methods, laying the foundation for increasing interest in human motion generation. Most research within this field focuses on generating human motions based on conditional signals, such as text, audio, and scene contexts. While significant advancements have been made in recent years, the task continues to pose challenges due to the intricate nature of human motion and its implicit relationship with conditional signals. In this survey, we present a comprehensive literature review of human motion generation, which, to the best of our knowledge, is the first of its kind in this field. We begin by introducing the background of human motion and generative models, followed by an examination of representative methods for three mainstream sub-tasks: text-conditioned, audio-conditioned, and scene-conditioned human motion generation. Additionally, we provide an overview of common datasets and evaluation metrics. Lastly, we discuss open problems and outline potential future research directions. We hope that this survey could provide the community with a comprehensive glimpse of this rapidly evolving field and inspire novel ideas that address the outstanding challenges., Comment: Accepted to TPAMI

Colorectal cancer is a deadly disease that has become increasingly prevalent in recent years. Early detection is crucial for saving lives, but traditional diagnostic methods such as colonoscopy and biopsy have limitations. Colonoscopy cannot provide detailed information within the tissues affected by cancer, while biopsy involves tissue removal, which can be painful and invasive. In order to improve diagnostic efficiency and reduce patient suffering, we studied machine-learningbased approach for colorectal tissue classification that uses acoustic resolution photoacoustic microscopy (ARPAM). With this tool, we were able to classify benign and malignant tissue using multiple machine learning methods. Our results were analyzed both quantitatively and qualitatively to evaluate the effectiveness of our approach.

Hydrophobic domains provide specific microenvironment for essential functional activities in life. Herein, we studied how the coassembling of peptides with catecholamines regulate the hydrophobic domain-containing nanostructures for fluorescence enhancement. By peptide encoding and coassembling with catecholamines of different hydrophilicities, a series of hierarchical assembling systems were constructed. In combination with molecular dynamics simulation, we experimentally discovered the hydrophobic domain of chromophore microenvironment regulates the fluorescence of coassembled nanostructures. Our results shed light on the rational design of fluorescent bio-coassembled nanoprobes for biomedical applications., Comment: 19 pages, 5 figures