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An ultra high performance liquid chromatography coupled to Fourier transform ion cyclotron resonance mass spectrometry (UHPLC-FT-ICR-MS) method was developed for the first time to study the in vivo metabolism of erysolin, a compound derived from cruciferous plants which has a definite effect of anti-tumor and anti-nerve injury. In this research, the chromatographic separation was performed on an ACQUITY UPLC® BEH C18 column (2.1 mm×100mm, 1.7μm, Waters, USA) and eluted by a gradient program, the identification work was achieved on a Bruker ultra-high resolution spectrometer in positive ion mode. Plasma, urine, feces and bile samples were collected from rats to screen metabolites after an intragastric administration of erysolin at the dose of 100mg/kg. As a result, the parent drug and a total of six phase II metabolites were detected and preliminarily identified by analyzing their MS and MS/MS spectrometry profiles. Our results indicated that erysolin mainly metabolized via the mercapturic acid metabolic pathway, erysolin first react with glutathione to form glutathione conjugate, followed by taking off the glutamic acid and glycine to form cysteine conjugate, then the N-acetylation reaction occurs, the product would be excreted out of the body at last. In conclusion, results obtained in our study may contribute to a better understanding of the metabolism process and characteristics of erysolin in vivo, and provide an important reference for future research.

The distribution of Neogene felsic porphyries intruding in earlier granitic batholiths was mainly controlled by north-south-tending rifting zones and normal faults. The main rock types of the felsic porphyries include granodiorite-porphyry, monzonitic granite-porphyry and quartz monzonitic porphyry. The porphyries are characterized by high SiO2 ((?)64.26%) and Al2O3 (15% at 70% SiO2), low Y and HREE (Yb) contents, strong enrichment of LILE and LERR, especially K and ST. Geochemical features of the porphyries show distinct adakitic magma affinity. Nd, Sr and Pb isotopic compositions of the porphyries form a linear alignment from MORB to EM2, suggesting a mixing of the MORB reservoir with the metasomatized mantle reservoir. Considering also the geochemical characteristics of the porphyries and the sequence of observable structural-thermal-magmatic events at Gangdise, it is thought that the Neogene porphyries were formed by partial melting of dead subducted oceanic crust in a post-collision setting. K-enrichment in the porphyries is attributed to the interaction of slab-derived melts, i.e., adakites, with the metasomatized mantle during the ascent. There might be a delamination of residual eclogites or amphibole eclogites before the eruption of potassic lava on the Tibetan plateau since 13 Ma.

Higher-order modes (HOMs) excited by electron beam traversing a superconducting rf (SRF) cavity contain lots of information and can be used for intra-cavity electron beam diagnostics. Unlike single bunch, multiple bunches would excite HOMs with a much complicated spectrum. In this paper, we present our recent research on HOMs excited by a high repetition rate electron beam in an SRF cavity. Especially, we focus on the integer multiple frequency peaks in the HOM spectrum, which are determined by the nearest eigen HOM peaks. The experiments were carried out on the DC-SRF photoinjector, which was operated at MHz repetition rate. The results agree well with theoretic analysis., Proceedings of the 6th Int. Particle Accelerator Conf., IPAC2015, Richmond, VA, USA

The straight beam line of SETF at Peking University is under construction, which consists of a DC-SRF photoinjector and a superconducting linac with two 9-cell cavities. Stable operation of the DC-SRF photoinjector has been realized and the design, manufacture and assembly of the cryomodule with two 9-cell cavities have been completed. Improved capacitive coupling RF power coupler and fast tuner with piezo are adopted, Proceedings of the 17th International Conference on RF Superconductivity, SRF2015, Whistler, BC, Canada