Search

Your search keyword '"Gao, Shen"' showing total 1,111 results
Start Over Author "Gao, Shen"
1,111 results on '"Gao, Shen"'

156. Is the Tradeoff between Folic Acid or/and Multivitamin Supplementation against Birth Defects in Early Pregnancy Reconsidered? Evidence Based on a Chinese Birth Cohort Study

Author

Su, Jian, primary, Gao, Shen, additional, Yan, Ruohua, additional, Liu, Ruixia, additional, Su, Shaofei, additional, Nie, Xiaolu, additional, Liu, Xiaohang, additional, Zhang, Enjie, additional, Xie, Shuanghua, additional, Liu, Jianhui, additional, Zhang, Yue, additional, Yue, Wentao, additional, Yin, Chenghong, additional, and Peng, Xiaoxia, additional

Published
2023
Full Text
View/download PDF

162. The Distribution of Etiology and Clinical Presentations of Birth Defects: A Preliminary Assessment of China Birth Cohort Study

Author

Liu, Xiaohang, primary, Liu, Ruixia, additional, Wang, Chen, additional, Yan, Ruohua, additional, Gao, Shen, additional, Su, Shaofei, additional, Nie, Xiaolu, additional, Su, Jian, additional, Zhang, Enjie, additional, Xie, Shuanghua, additional, Liu, Jianhui, additional, Zhang, Yue, additional, Yue, Wentao, additional, Peng, Xiaoxia, additional, and Yin, Chenghong, additional

Published
2023
Full Text
View/download PDF

167. The CLOCK Data-Aware Eviction Approach: Towards Processing Linked Data Streams with Limited Resources

Author

Gao, Shen, Scharrenbach, Thomas, Bernstein, Abraham, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Kobsa, Alfred, editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Weikum, Gerhard, editor, Presutti, Valentina, editor, d’Amato, Claudia, editor, Gandon, Fabien, editor, d’Aquin, Mathieu, editor, Staab, Steffen, editor, and Tordai, Anna, editor

Published
2014
Full Text
View/download PDF

171. Vasoprotective Effects of Hyperoside against Cerebral Ischemia/Reperfusion Injury in Rats: Activation of Large-Conductance Ca2+-Activated K+ Channels.

Author

Hong, Wen-Ming, Xie, Yue-Wu, Zhao, Meng-Yu, Yu, Tian-Hang, Wang, Li-Na, Xu, Wan-Yan, Gao, Shen, Cai, Hua-Bao, Guo, Yan, and Zhang, Fang

Subjects
CEREBRAL ischemia, REPERFUSION injury, VASCULAR smooth muscle, BASILAR artery, CEREBRAL circulation
Abstract

Hyperoside (Hyp), a kind of Chinese herbal medicine, exerts multiple therapeutic effects on many diseases. However, the role and mechanisms of Hyp in vascular pathophysiology in ischemic stroke need to be further established. The study aimed to investigate the role of (large-conductance Ca2+-activated K+) BK channels on the vasoprotection of Hyp against cerebral ischemia and reperfusion (I/R) injury in rats. The concentration gradient of Hyp was pretreated in both the middle cerebral artery occlusion and reperfusion model and oxygen-glucose deprivation/reoxygenation (OGD/R) model of primary vascular smooth muscle cells (VSMCs) in rats. A series of indicators were detected, including neurological deficit score, infarct volume, malondialdehyde (MDA), superoxide dismutase (SOD), cerebral blood flow (CBF), cell viability, membrane potential, and BK channels α- and β1-subunits expression. The results showed that Hyp significantly reduced infarct volume and ameliorated neurological dysfunction in I/R-injured rats. Besides, the effects of I/R-induced reduction of BK channels α- and β1-subunits expression were significantly reversed by Hyp in endothelial-denudated cerebral basilar arteries. Furthermore, the protective effect against I/R-induced increases of MDA and reduction of SOD as well as CBF induced by Hyp was significantly reversed by iberiotoxin (IbTX). In OGD/R-injured VSMCs, downregulated cellular viability and BK channels β1-subunits expression were remarkably reversed by Hyp. However, neither OGD/R nor Hyp affected BK channels α-subunits expression, and Hyp failed to induced hyperpolarization of VSMCs. Moreover, the protective effect against OGD/R-induced reduction of cell viability and SOD level and increases of MDA production induced by Hyp was significantly reversed by IbTX in VSMCs. The study indicates that Hyp has the therapeutic potential to improve vascular outcomes, and the mechanism is associated with suppressing oxidative stress and improving CBF through upregulating BK channels. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

183. A tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma

Author

Zhang, Shuyue, Jiao, Xiuxiu, Heger, Michal, Gao, Shen, He, Mei, Xu, Nan, Zhang, Jigang, Zhang, Mingjian, Yu, Yuan, Ding, Baoyue, Ding, Xueying, Afd Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Pharmaceutics, Afd Pharmaceutics, Sub Membrane Biochemistry & Biophysics, and Pharmaceutics

Subjects
Radiation-Sensitizing Agents, mic-roenvironment-responsive, Brain Neoplasms, Pharmaceutical Science, General Medicine, Chemoradiotherapy, chemo-radiotherapy, Mice, targeted nanotherapeutics, Doxorubicin, Cell Line, Tumor, Tumor Microenvironment, Animals, Humans, radiosensitization, Glioblastoma, Micelles
Abstract

Glioblastoma is rather recalcitrant to existing therapies and effective interventions are needed. Here we report a novel microenvironment-responsive micellar system (ch-K5(s-s)R8-An) for the co-delivery of the radiosensitizer Dbait and the chemotherapeutic doxorubicin (DOX) to glioblastoma. Accordingly, the ch-K5(s-s)R8-An/(Dbait-DOX) micelles plus radiotherapy (RT) treatment resulted in a high degree of apoptosis and DNA damage, which significantly reduced cell viability and proliferation capacity of U251 cells to 64.0% and 16.3%, respectively. The angiopep-2-modified micelles exhibited substantial accumulation in brain-localized U251 glioblastoma xenografts in mice compared to angiopep-2-lacking micelles. The ch-K5(s-s)R8-An/(Dbait-DOX) + RT treatment group exhibited the smallest tumor size and most profound tumor tissue injury in orthotopic U251 tumors, leading to an increase in median survival time of U251 tumor-bearing mice from 26 days to 56 days. The ch-K5(s-s)R8-An/(Dbait-DOX) micelles can be targeted to brain-localized U251 tumor xenografts and sensitize the tumor to chemotherapy and radiotherapy, thereby overcoming the inherent therapeutic challenges associated with malignant glioblastoma.

Published
2022

194. DigestJoin: Expediting Joins on Solid-State Drives

Author

Gao, Shen, Li, Yu, Xu, Jianliang, Choi, Byron, Hu, Haibo, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Kitagawa, Hiroyuki, editor, Ishikawa, Yoshiharu, editor, Li, Qing, editor, and Watanabe, Chiemi, editor

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results