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772 results on '"Gallo, S. A."'

151. P1DH.7 - Chemoresistive Sensors for Cancer Pre-Screening in Human Tissue

Author

Astolfi, M., primary, Anania, G., additional, Benedusi, M., additional, Guidi, V., additional, Landini, N., additional, Palmonari, C., additional, Rispoli, G., additional, Secchiero, P., additional, Tisato, V., additional, Gallo, S., additional, Valt, M., additional, Zonta, G., additional, Malagù, C., additional, and Gherardi, S., additional

Published
2018
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152. Caratterizzazione dosimetrica della facility a neutroni termici del reattore TRIGA di Pavia: studio della dose da fotoni mediante rivelatori ESR di alanina

Author

Protti, N., Ferrari, M., Ballarini, F., Bortolussi, S., Carante, M., De Bari, A., Giroletti, E., Postuma, I., Gallo, S., Marrale, M., Longo, A., Panzeca, S., Iacoviello, G., Altieri, S., Protti, N., Ferrari, M., Ballarini, F., Bortolussi, S., Carante, M., De Bari, A., Giroletti, E., Postuma, I., Gallo, S., Marrale, M., Longo, A., Panzeca, S., Iacoviello, G., and Altieri, S.

Subjects
BNCT, ESR, EPR, ALANINE, MC, BORON, Settore ING-IND/20 - Misure E Strumentazione Nucleari, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Abstract

The optimization of the procedures of Neutron Capture Therapy (NCT) for cancer treatments involves research for beam characterization. One major issue for this therapy is the reliable dosimetric determination of the various (neutronic and photonic) components of the employed beam. In particular, the precise and accurate measurements of the gamma photon component is fundamental for evaluating the risks to healthy tissues hit by the mixed field. Among solid state dosimeters the alanine detectors read by Electron Paramagnetic Resonance (EPR) technique present several advantages such as: tissue equivalence for photon and electron beams, linearity of its dose-response over a wide range, high stability of radiation induced free radicals, no destructive read-out procedure, no sample treatment before EPR signal measurement and low cost of the dosimeters. These features associated with the possibility of recognizing the various components of a mixed radiation fields makes alanine a good candidate for dosimetry in neutron-gamma fields. In this work we determine the gamma component of the mixed radiation field in thermal column of the Triga Reactor of University of Pavia (which is used for experimental activities on NCT) by means of alanine EPR dosimeters. Commercial alanine dosimeters produced by Synergy Health (Germany) were exposed in three positions in the thermal column; the irradiations were performed inside graphite holders to avoid use of hydrogenous phantoms for minimizing the gamma contribution due to the plastic holders. EPR measurements were carried out through Bruker ECS106 spectrometer equipped with a TE102 rectangular cavity. In order to isolate the gamma components of the mixed field two kinds of irradiations were carried out inside a lithium carbonate box (wherein the thermal neutron component is heavily reduced) and outside of it. MCNP Monte Carlo simulations of the irradiation set-up were carried out, calculating the contributions of the various components present in the mixed field (thermal and fast neutron and gamma). The experimental values are compared with the computations of the Monte Carlo simulations and the results are discussed on the basis of the mixed field features and on the response of alanine dosimeters to high and low LET radiations.

Published
2014

153. Caratterizzazione del campo misto neutroni-gamma nella colonna termica del reattore TRIGA di Pavia tramite attivazione neutronica e rivelatori ad alanina

Author

Bortolussi, S., Ballarini, F., Carante, M., De Bari, A., Giroletti, E., Postuma, I., Protti, N., Ferrari, I., Nigg, D., Gallo, S., Iacoviello, G., Longo, A., Marrale, M., Panzeca, S., Altieri, S., Bortolussi, S, Ballarini, F, Carante, M.P, De Bari, A, Giroletti, E, Postuma, I, Protti, N, Ferrari, I, Nigg, D.W, Gallo, S, Iacoviello, G, Longo, A, Marrale, M, Panzeca, S, and Altieri, S

Subjects
Settore FIS/01 - Fisica Sperimentale, Alanina, BNCT, neutroni termici, LENA, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Published
2014

154. The effect of particle size on pigments colour

Author

Gueli, ANNA MARIA, Burrafato, G., Gallo, S., Pasquale, S., Stella, G., Troja, S. O., Gueli, A, Burrafato, G, Gallo, S, Pasquale, S, Stella, G, and Troja S.O

Subjects
Pigment, size, SRF%, CIELAB, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Published
2014
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155. Le melanzane dell'area sud della Basilicata

Author

Cerbino D., Illiano M., Di Napoli A., Cirigliano M., Zienna P., Gallo S., Laghetti G., De Lisi A., Sonnante G., Nigro D., Losavio F.P., Stimolo L., Giunta R., Piergiovanni A.R., Morgese A., Hammer K., and Figliuolo G.

Subjects
caratterizzazione, agrotecnica, melanzana, dati genetici e biochimici
Abstract

Studio multidisciplinare (morfo-agronomica, biochimica e genetica) delle melanzane coltivate nelle zone meridionali della regione Basilicata.

Published
2016

157. Nuclear magnetic resonance as a non-destructive analysis for the study of a new stone consolidation treatment

Author

Zuena M., Zendri E., Tomasin P., Alberghina M.F., Gallo S., Longo A., Marrale M., and Brai M.

Subjects
porosity, stone conservation, NMR relaxation, limestone
Abstract

Limestone, used in artistic and architectural fields because of its composition and textural characteristics, is particularly susceptible to decay. Its constant exposure to a combination of weathering factors, causes an increase in porosity and a loss of material cohesion. In order to deal with this deterioration process, Ca(OEt)2 as a novel product developed during the EC NANOMATCH project, is tested to consolidate four types of limestone widely employed within Italian Cultural Heritage: Noto stone, Lecce stone, Carrara marble and Vicenza stone [1]. Pore-space properties, such as pore-size distribution and connected porosity, are crucial factors in the evaluation of a consolidation product and, throughout this study, they are analysed with NMR relaxometry of water 1H nuclei. This technique, being both non-destructive and non-invasive, is able to obtain both longitudinal (T1) and transverse (T2) relaxation time distributions of water in the stones' pores, before and after the consolidation treatment [2]. The results demonstrate that T2 is more sensitive than T1 in detecting pores of small dimension for all lithotypes, but not for marble which gives results that are not easily legible due to its low open porosity and a small quantity of absorbed water. Combining relaxation data and micro-structural studies performed by MIP and SEM measurements, a better understanding is obtained of the changes within stone porosity. The results confirm that NMR technique could be a useful tool for the evaluation of consolidation treatment on stone.

Published
2016

159. Phenol compounds as new materials for Electron Paramagnetic Resonance dosimetry in clinical photon and electron beams

Author

Gallo, S., Iacoviello, G., Panzeca, S., Dondi, D., Longo, A., Veronese, I., Marrale, M., S. GALLO, G. IACOVIELLO, S. PANZECA, D. DONDI, A. LONGO, I. VERONESE, and M. MARRALE

Subjects
Settore FIS/01 - Fisica Sperimentale, ESR, EPR, Solid State Dosimeters, Clinical Beams, New Materials, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Abstract

In the last decades several research laboratories have shown an increasing interest aimed at extending the applicability of Electron Paramagnetic Resonance (EPR) dosimetry to radiotherapy with different types of radiation beams. EPR is a spectroscopic method for investigating the structure and dynamics of such paramagnetic species. Free radicals are known to be produced when a compound is irradiated with ionizing radiations. The concentration of radiation-induced free radicals is proportional to the energy released inside in the medium and this allows for dosimetric measurements through EPR technique. The use of alanine as a dosimetric material gave the possibility to apply EPR spectroscopy for high-dose standardization and dose control in radiation processing (Marrale 2016). The EPR dosimetric method has many advantages such as simple and rapid dose evaluation, the readout procedure is non-destructive, linear response of many organic and inorganic compounds. EPR detectors show a behavior that suggest possible applications for various kinds of beams used for radiation therapy. Nowadays, the most widely used organic compound as a dosimeter is the alanine. However, many researches are in progress with the aim at improving sensitivity of EPR dosimetry for doses much smaller than 1 Gy. More sensitive materials than alanine are needed to make the EPR dosimeter competitive with other dosimetry systems. Our research group has started an investigation of the EPR response of some phenols compounds for possible EPR dosimetric applications suitable features, such as high efficiency of radiation-matter energy transfer and radical stability at room temperature. Phenols are compounds possessing a benzene ring attached to a OH group. After irradiation the final product is a stable phenoxy radical. The stability of such radical can be improved by adding other alkyl chains which can be attached to the benzene ring. The phenol octadecyl-3-(3,5-di-tert.butyl-4-hydroxyphenyl)-propionate gave interesting results. Moreover, its high molecular weight, the low volatility and the compatibility with the dosimeter binding material (wax) are advantages with respect to lower molecular weight phenols. In this work we report the EPR investigation of phenols exposed to clinical photon and electron beams (Gallo, 2016). The dosimetric features of these EPR dosimeters (dependence on microwave power and modulation amplitude, their response after gamma and electron irradiations, dependence on beam type and energy, the detection limits for both beam typologies, signal stability after irradiation) were investigated and the results are reported.

Published
2016

167. The two‐component system CpxAR is essential for virulence in the phytopathogen bacteria Dickeya dadantii EC3937

Author

bontemps-gallo, S. (sébastien), Madec, E. (Edwige), Lacroix, J-M. (Jean-Marie), CNRS, Université de Lille, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF], and Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF]

Subjects
CpxAR, Virulence, stress, plant pathogen, D. dadantii
Abstract

The CpxAR two‐component system is present in many Proteobacteria. It controls expression of genes required to maintain envelope integrity in response to environmental injury. Consequently, this two‐component system was shown to be required for virulence of several zoo‐pathogens, but it has never been investigated in phyto‐pathogens. In this paper, we investigate the role of the CpxAR two‐component system in vitro and in vivo in Dickeya dadantii, an enterobacterial phytopathogen that causes soft‐rot disease in a large variety of plant species. cpxA null mutant displays a constitutively phosphorylated CpxR phenotype as shown by direct analysis of phosphorylation of CpxR by a Phos‐Tag retardation gel approach. Virulence in plants is completely abolished in cpxA or cpxR mutants of D. dadantii. In planta, CpxAR is only activated at an early stage of the infection process as shown by Phos‐Tag and gene fusion analyses. To our knowledge, this is the first time that the timing of CpxAR phosphorelay activation has been investigated during the infection process by direct monitoring of response regulator phosphorylation. 17;11

Published
2015

168. The opgC gene is required for OPGs succinylation and is osmoregulated through RcsCDB and EnvZ/OmpR in the phytopathogen Dickeya dadantii

Author

bontemps-gallo, S. (sébastien), Madec, E. (Edwige), Masselot, C. (Catherine), Souche, E. (Erika), Dondeyne, J. (Jacqueline), Lacroix, J-M. (Jean-Marie), CNRS, Université de Lille, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF], Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF], and Center for Human Genetics, University of Leuven School of Medicine

Subjects
musculoskeletal diseases, Virulence, Genetic Complementation Test, Osmolar Concentration, Article, Osmoregulation, Bacterial Proteins, Enterobacteriaceae, Gene Order, Periplasm, Escherichia coli, bacteria, Phosphorylation, Promoter Regions, Genetic, Glucans, Genome, Bacterial, Protein Binding
Abstract

Osmoregulated periplasmic glucans (OPGs) are a family of periplasmic oligosaccharides found in the envelope of most Proteobacteria. They are required for virulence of zoo- and phyto-pathogens. The glucose backbone of OPGs is substituted by various kinds of molecules depending on the species, O-succinyl residues being the most widely distributed. In our model, Dickeya dadantii, a phytopathogenic bacteria causing soft rot disease in a wide range of plant species, the backbone of OPGs is substituted by O-succinyl residues in media of high osmolarity and by O-acetyl residues whatever the osmolarity. The opgC gene encoding a transmembrane protein required for the succinylation of the OPGs in D. dadantii was found after an in silico search of a gene encoding a protein with the main characteristics recovered in the two previously characterized OpgC of E. coli and R. sphaeroides, i.e. 10 transmembrane segments and one acyl-transferase domain. Characterization of the opgC gene revealed that high osmolarity expression of the succinyl transferase is controlled by both the EnvZ-OmpR and RcsCDB phosphorelay systems. The loss of O-succinyl residue did not affect the virulence of D. dadantii, suggesting that only the glucose backbone of OPGs is required for virulence. 6;1

Published
2015

169. In-vehicle vibration study of child safety seats

Author

Giacomin, J. and Gallo, S.

Subjects
Vibration research -- Evaluation, Child safety seats -- Evaluation, Child safety seats -- Research, Architecture and design industries, Business
Abstract

The potential inability of evaluating child comfort by means of existing whole-body vibration standards is discussed. The measurement of different automobiles, child seat and child, the vibrations arriving at the child and the comparison of these to the vibrations between the driver and the seating system is explained.

Published
2003

170. A self-injection acceleration test experiment for the FLAME laser

Author

Labate, L, Anelli, F, Bacci, A, Batani, D, Bellaveglia, M, Benedetti, C, Benocci, R, Cacciotti, L, Cecchetti, C, Ciricosta, O, Clozza, A, Cultrera, L, Di Pirro, G, Drenska, N, Faccini, R, Ferrario, M, Filippetto, D, Gallo, S, Fioravanti, S, Gamucci, A, Gatti, G, Ghigo, A, Giulietti, A, Giulietti, D, Koster, P, Levato, T, Lollo, V, Pace, E, Pathak, N, Rossi, A, Serafini, L, Turchetti, G, Vaccarezza, C, Valente, P, Vicario, C, Gizzi, L, Labate L., Anelli F., Bacci A., Batani D., Bellaveglia M., Benedetti C., Benocci R., Cacciotti L., Cecchetti C. A., Ciricosta O., Clozza A., Cultrera L., Di Pirro G., Drenska N., Faccini R., Ferrario M., Filippetto D., Gallo S., Fioravanti S., Gamucci A., Gatti G., Ghigo A., Giulietti A., Giulietti D., Koster P., Levato T., Lollo V., Pace E., Pathak N., Rossi A., Serafini L., Turchetti G., Vaccarezza C., Valente P., Vicario C., Gizzi L. A., Labate, L, Anelli, F, Bacci, A, Batani, D, Bellaveglia, M, Benedetti, C, Benocci, R, Cacciotti, L, Cecchetti, C, Ciricosta, O, Clozza, A, Cultrera, L, Di Pirro, G, Drenska, N, Faccini, R, Ferrario, M, Filippetto, D, Gallo, S, Fioravanti, S, Gamucci, A, Gatti, G, Ghigo, A, Giulietti, A, Giulietti, D, Koster, P, Levato, T, Lollo, V, Pace, E, Pathak, N, Rossi, A, Serafini, L, Turchetti, G, Vaccarezza, C, Valente, P, Vicario, C, Gizzi, L, Labate L., Anelli F., Bacci A., Batani D., Bellaveglia M., Benedetti C., Benocci R., Cacciotti L., Cecchetti C. A., Ciricosta O., Clozza A., Cultrera L., Di Pirro G., Drenska N., Faccini R., Ferrario M., Filippetto D., Gallo S., Fioravanti S., Gamucci A., Gatti G., Ghigo A., Giulietti A., Giulietti D., Koster P., Levato T., Lollo V., Pace E., Pathak N., Rossi A., Serafini L., Turchetti G., Vaccarezza C., Valente P., Vicario C., and Gizzi L. A.

Abstract

A 250-TW laser system (FLAME - Frascati laser for acceleration and multidisciplinary experiments) is now in its commissioning phase in a new laboratory at LNF-INFN in the framework of the PLASMONX (Plasma acceleration and monochromatic X-ray generation) project. The laser will deliver25fs duration pulses with an energy up to 6J, at a 10Hz repetition rate. An ad hoc target area has also been designed and is currently being set up, allowing the first test experiments of electron laser wakefield acceleration to be carried out over the next few months in a safe, radiation-protected environment. An overview of the main features of the laser system and target area is given, along with a survey of the design and set-up of the self-injection test experiment, which is expected to reach the production of sub-GeV electron bunches.

Published
2010

171. Misure di colore su film radiocromici: nuove frontiere per la dosimetria

Author

Gueli, ANNA MARIA, Asero, G., Burrafato, G., De Vincolis, R., Gallo, S., Stella, G., Troja, S. O., Gueli, A, Asero, G, Burrafato, G, De Vincolis, R, Gallo. S, Stella, G, and Troja, S O

Subjects
Film radiocromici, Dosimetria, Colorimetria, LINAC, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Published
2013

172. Characterization of Yb-doped silica optical fiber as real-Time dosimeter

Author

Veronese, I, Payne, SA, Chiodini, N, Cialdi, S, D'Ippolito, E, Fasoli, M, Gallo, S, Mones, E, Vedda, A, Loi, G, Veronese, I, Payne, SA, Chiodini, N, Cialdi, S, D'Ippolito, E, Fasoli, M, Gallo, S, Mones, E, Vedda, A, and Loi, G

Abstract

The near-infrared radioluminescence and dosimetric properties of Yb-doped silica optical fibers, coupled with an optical detector prototype based on an avalanche photo-diode, were studied by irradiating the fibers with clinical beams generated by a Varian Trilogy accelerator. The performances of the system in standard and small field sizes have been also investigated comparing the output factor, percent depth dose and off axis ratio measurements of the prototypal dosimetric system with other commercial sensors. The results demonstrated that the drawback due to the stem effect in Yb-doped silica optical fibers can be managed in a simple but effective way by optical filtering. These features, together with the accuracy and precision achieved by Ybdoped fibers in relative dose assessments make the device promising for in-vivo dosimetry studies in radiation therapy.

Published
2017

173. Real-time dosimetry with Yb-doped silica optical fibres

Author

Veronese, I, Chiodini, N, Cialdi, S, D'Ippolito, E, Fasoli, M, Gallo, S, La Torre, S, Mones, E, Vedda, A, Loi, G, CHIODINI, NORBERTO, FASOLI, MAURO, VEDDA, ANNA GRAZIELLA, Loi, G., Veronese, I, Chiodini, N, Cialdi, S, D'Ippolito, E, Fasoli, M, Gallo, S, La Torre, S, Mones, E, Vedda, A, Loi, G, CHIODINI, NORBERTO, FASOLI, MAURO, VEDDA, ANNA GRAZIELLA, and Loi, G.

Abstract

Over the years, many efforts have been made to develop radiation detectors to handle the complex issues of small field dosimetry and achieve the increasing accuracy, precision and in vivo dose monitoring required by the new advanced treatment modalities. In this context, interest has surged in the development of sensors based on scintillating optical fibres. In this paper, the near-infrared radioluminescence and dosimetric properties of Yb-doped silica optical fibres, coupled with a laboratory prototype based on an avalanche photodiode, were studied by irradiating the fibres with photons and electron beams generated by a Varian Trilogy accelerator. The performance of the system in standard and small field sizes has also been investigated, comparing the output factor, percentage depth dose and off-axis ratio measurements of the prototypal detector with other commercial sensors, including the Exradin W1 scintillator. The results of this study demonstrate that the drawback due to the stem effect in Yb-doped silica optical fibres can be managed in a simple but effective way by optical filtering. The robustness of the system in complex dosimetric scenarios and the accuracy and precision achieved by Yb-doped fibres in relative dose assessments suggest an effective use of the system for real-time in vivo dosimetry applications

Published
2017

174. Incidence, Risk Factors and Outcome of Pre-engraftment Gram-Negative Bacteremia after Allogeneic and Autologous Hematopoietic Stem Cell Transplantation: An Italian Prospective Multicenter Survey

Author

Girmenia, C., Bertaina, A., Piciocchi, A., Perruccio, K., Algarotti, A., Busca, A., Cattaneo, C., Raiola, A. M., Guidi, S., Iori, A. P., Candoni, A., Irrera, G., Milone, G., Marcacci, G., Scime, R., Musso, M., Cudillo, L., Sica, Simona, Castagna, Luigi, Corradini, P., Marchesi, F., Pastore, D., Alessandrino, E. P., Annaloro, C., Ciceri, F., Santarone, S., Nassi, L., Farina, C., Viscoli, C., Rossolini, G. M., Bonifazi, F., Rambaldi, A., Capria, S., Mastronuzzi, A., Pagliara, D., Bernaschi, P., Amico, L., Carotti, A., Mencacci, A., Bruno, Brunella, Costa, C., Passi, A., Ravizzola, G., Angelucci, E., Marchese, Alessandra Maria, Pecile, P., Ventura, Giulio, Fanin, R., Scarparo, C., Barbaro, A., Leotta, Salvatore Nuccio, Marchese, A. E., Becchimanzi, C., Donnarumma, D., Tringali, S., Baldi, M. T., Scalone, R., Picardi, A., Arcese, W., Fontana, Cecilia Alejandra, Giammarco, S., Spanu, Teresa, Crocchiolo, R., Casari, E., Mussetti, A., Conte, Eliana, Ensoli, F., Miragliotta, G., Marone, P., Arghittu, M., Greco, R., Forcina, A., Chichero, P., Di Bartolomeo, P., Fazii, P., Kroumova, V., Decembrino, N., Zecca, M., Pisapia, Giovanni, Palazzo, G., Lanino, E., Faraci, M., Castagnola, E., Bandettini, R., Pastano, R., Sammassimo, S., Passerini, R., Stefani, P. M., Gherlinzoni, F., Rigoli, R., Prezioso, L., Cambo, B., Calderaro, A., Carella, A. M., Cascavilla, N., Labonia, M. T., Celeghini, I., Mordini, N., Piana, F., Vacca, A., Sanna, Maria Maddalena, Podda, G., Corsetti, M. T., Rocchetti, A., Cilloni, D., De Gobbi, M., Bianco, O., Fagioli, F., Carraro, F., De Intinis, G., Severino, A., Proia, Anna Silvia, Parisi, G., Vallisa, D., Confalonieri, Marco, Russo, D., Malagola, M., Galieni, P., Falcioni, S., Travaglini, V., Raimondi, Maria Rosa, Borghero, C., Pavan, Giuseppe, Prete, A., Belotti, T., Ambretti, S., Imola, M., Mianulli, A. M., Pedna, M. F., Cesaro, S., Lo Cascio, G., Ferrari, A., Piedimonte, M., Santino, I., Calandrelli, M., Olivieri, Alessandra, Orecchioni, F., Mirabile, M., Centurioni, R., Gironacci, L., Caravelli, D., Gallo, S., De Filippi, M., Cupelli, L., Dentamaro, T., Falco, S., Eugenio, O. S., Marotta, S., Risitano, A., Lula, D., Musto, P., Pietrantuono, G., Traficante, A., Cerchiara, E., Tirindelli, M. C., Dicuonzo, G., Chierichini, A., Anaclerico, B., Placanica, P., Sica S. (ORCID:0000-0003-2426-3465), Castagna L., Bruno B., Marchese A., Ventura G. (ORCID:0000-0002-0304-7264), Leotta S., Fontana C., Spanu T. (ORCID:0000-0003-1864-5184), Conte E., Pisapia G., Sanna M., Proia A., Confalonieri M. (ORCID:0000-0002-3708-379X), Raimondi R., Pavan G., Olivieri A., Girmenia, C., Bertaina, A., Piciocchi, A., Perruccio, K., Algarotti, A., Busca, A., Cattaneo, C., Raiola, A. M., Guidi, S., Iori, A. P., Candoni, A., Irrera, G., Milone, G., Marcacci, G., Scime, R., Musso, M., Cudillo, L., Sica, Simona, Castagna, Luigi, Corradini, P., Marchesi, F., Pastore, D., Alessandrino, E. P., Annaloro, C., Ciceri, F., Santarone, S., Nassi, L., Farina, C., Viscoli, C., Rossolini, G. M., Bonifazi, F., Rambaldi, A., Capria, S., Mastronuzzi, A., Pagliara, D., Bernaschi, P., Amico, L., Carotti, A., Mencacci, A., Bruno, Brunella, Costa, C., Passi, A., Ravizzola, G., Angelucci, E., Marchese, Alessandra Maria, Pecile, P., Ventura, Giulio, Fanin, R., Scarparo, C., Barbaro, A., Leotta, Salvatore Nuccio, Marchese, A. E., Becchimanzi, C., Donnarumma, D., Tringali, S., Baldi, M. T., Scalone, R., Picardi, A., Arcese, W., Fontana, Cecilia Alejandra, Giammarco, S., Spanu, Teresa, Crocchiolo, R., Casari, E., Mussetti, A., Conte, Eliana, Ensoli, F., Miragliotta, G., Marone, P., Arghittu, M., Greco, R., Forcina, A., Chichero, P., Di Bartolomeo, P., Fazii, P., Kroumova, V., Decembrino, N., Zecca, M., Pisapia, Giovanni, Palazzo, G., Lanino, E., Faraci, M., Castagnola, E., Bandettini, R., Pastano, R., Sammassimo, S., Passerini, R., Stefani, P. M., Gherlinzoni, F., Rigoli, R., Prezioso, L., Cambo, B., Calderaro, A., Carella, A. M., Cascavilla, N., Labonia, M. T., Celeghini, I., Mordini, N., Piana, F., Vacca, A., Sanna, Maria Maddalena, Podda, G., Corsetti, M. T., Rocchetti, A., Cilloni, D., De Gobbi, M., Bianco, O., Fagioli, F., Carraro, F., De Intinis, G., Severino, A., Proia, Anna Silvia, Parisi, G., Vallisa, D., Confalonieri, Marco, Russo, D., Malagola, M., Galieni, P., Falcioni, S., Travaglini, V., Raimondi, Maria Rosa, Borghero, C., Pavan, Giuseppe, Prete, A., Belotti, T., Ambretti, S., Imola, M., Mianulli, A. M., Pedna, M. F., Cesaro, S., Lo Cascio, G., Ferrari, A., Piedimonte, M., Santino, I., Calandrelli, M., Olivieri, Alessandra, Orecchioni, F., Mirabile, M., Centurioni, R., Gironacci, L., Caravelli, D., Gallo, S., De Filippi, M., Cupelli, L., Dentamaro, T., Falco, S., Eugenio, O. S., Marotta, S., Risitano, A., Lula, D., Musto, P., Pietrantuono, G., Traficante, A., Cerchiara, E., Tirindelli, M. C., Dicuonzo, G., Chierichini, A., Anaclerico, B., Placanica, P., Sica S. (ORCID:0000-0003-2426-3465), Castagna L., Bruno B., Marchese A., Ventura G. (ORCID:0000-0002-0304-7264), Leotta S., Fontana C., Spanu T. (ORCID:0000-0003-1864-5184), Conte E., Pisapia G., Sanna M., Proia A., Confalonieri M. (ORCID:0000-0002-3708-379X), Raimondi R., Pavan G., and Olivieri A.

Abstract

Background Gram-negative bacteremia (GNB) is a major cause of illness and death after hematopoietic stem cell transplantation (HSCT), and updated epidemiological investigation is advisable. Methods We prospectively evaluated the epidemiology of pre-engraftment GNB in 1118 allogeneic HSCTs (allo-HSCTs) and 1625 autologous HSCTs (auto-HSCTs) among 54 transplant centers during 2014 (SIGNB-GITMO-AMCLI study). Using logistic regression methods. we identified risk factors for GNB and evaluated the impact of GNB on the 4-month overall-survival after transplant. Results The cumulative incidence of pre-engraftment GNB was 17.3% in allo-HSCT and 9% in auto-HSCT. Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa were the most common isolates. By multivariate analysis, variables associated with GNB were a diagnosis of acute leukemia, a transplant from a HLA-mismatched donor and from cord blood, older age, and duration of severe neutropenia in allo-HSCT, and a diagnosis of lymphoma, older age, and no antibacterial prophylaxis in auto-HSCT. A pretransplant infection by a resistant pathogen was significantly associated with an increased risk of posttransplant infection by the same microorganism in allo-HSCT. Colonization by resistant gram-negative bacteria was significantly associated with an increased rate of infection by the same pathogen in both transplant procedures. GNB was independently associated with increased mortality at 4 months both in allo-HSCT (hazard ratio, 2.13; 95% confidence interval, 1.45-3.13; P <.001) and auto-HSCT (2.43; 1.22-4.84; P =.01). Conclusions Pre-engraftment GNB is an independent factor associated with increased mortality rate at 4 months after auto-HSCT and allo-HSCT. Previous infectious history and colonization monitoring represent major indicators of GNB. Clinical Trials registration NCT02088840.

Published
2017

175. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

Author

Majounie E, Renton AE, Mok K, Dopper EG, Waite A, Rollinson S, Chiò A, Restagno G, Nicolaou N, Simon Sanchez J, van Swieten JC, Abramzon Y, Johnson JO, Sendtner M, Pamphlett R, Orrell RW, Mead S, Sidle KC, Houlden H, Rohrer JD, Morrison KE, Pall H, Talbot K, Ansorge O, Chromosome 9 ALS/FTD Consortium, French research network on FTLD/FTLD/ALS, ITALSGEN Consortium, Adamson G, Bayer AJ, Beck J, Callister JB, Blake DJ, Blumen SC, Collinge J, Dunckley T, Ealing J, East S, Elman L, Gerhard A, Guerreiro RJ, Gwinn K, Halliwell N, Hamdalla HH, Hewitt C, Ince P, Jablonka S, James C, Kent L, Knock JC, Lynch T, Mahoney C, Mann D, Neal J, Norris D, O'Dowd S, Richardson A, Rossor M, Rothstein J, Scholz SW, Snowden J, Stephan DA, Toulson G, Turner MR, Warren JD, Young K, Weng YH, Kuo HC, Lai SC, Huang CL, Camuzat A, Entraingues L, Guillot Noël, Verpillat P, Blanc F, Camu W, Clerget Darpoux F, Corcia P, Couratier P, Didic M, Dubois B, Duyckaerts C, Guedj E, Golfier V, Habert MO, Hannequin D, Lacomblez L, Meininger V, Salachas F, Levy R, Michel BF, Pasquier F, Puel M, Thomas Anterion C, Sellal F, Vercelletto M, Moglia C, Cammarosano S, Canosa A, Gallo S, Brunetti M, Ossola I, Marinou K, Papetti L, Pisano F, Pinter GL, Conte A, Luigetti M, Zollino M, Lattante S, Marangi G, la Bella V, Spataro R, Colletti T, Battistini S, Ricci C, Caponnetto C, Mancardi G, Mandich P, Salvi F, Bartolomei I, Mandrioli J, Sola P, Lunetta C, Penco S, Conforti FL, Gambardella A, Quattrone A, Volanti P, Floris G, Cannas A, Piras V, Marrosu F, Marrosu MG, Murru MR, Pugliatti M, Parish LD, Sotgiu A, Solinas G, Ulgheri L, Ticca A, Simone I, Logroscino G, Hernandez DG, Arepalli S, Sabatelli M, Mora G, Corbo M, Giannini F, Calvo A, Englund E, Borghero G, Floris GL, Remes AM, Laaksovirta H, McCluskey L, Trojanowski JQ, Van Deerlin VM, Schellenberg GD, Nalls MA, Drory VE, Lu CS, Yeh TH, Ishiura H, Takahashi Y, Tsuji S, Le Ber I, Brice A, Drepper C, Williams N, Kirby J, Shaw P, Hardy J, Tienari PJ, Heutink P, Morris HR, Pickering Brown S, Traynor BJ, MONSURRO', Maria Rosaria, TEDESCHI, Gioacchino, Majounie, E, Renton, Ae, Mok, K, Dopper, Eg, Waite, A, Rollinson, S, Chiò, A, Restagno, G, Nicolaou, N, Simon Sanchez, J, van Swieten, Jc, Abramzon, Y, Johnson, Jo, Sendtner, M, Pamphlett, R, Orrell, Rw, Mead, S, Sidle, Kc, Houlden, H, Rohrer, Jd, Morrison, Ke, Pall, H, Talbot, K, Ansorge, O, Chromosome, 9 ALS/FTD Consortium, French research network on, Ftld/ftld/al, Italsgen, Consortium, Adamson, G, Bayer, Aj, Beck, J, Callister, Jb, Blake, Dj, Blumen, Sc, Collinge, J, Dunckley, T, Ealing, J, East, S, Elman, L, Gerhard, A, Guerreiro, Rj, Gwinn, K, Halliwell, N, Hamdalla, Hh, Hewitt, C, Ince, P, Jablonka, S, James, C, Kent, L, Knock, Jc, Lynch, T, Mahoney, C, Mann, D, Neal, J, Norris, D, O'Dowd, S, Richardson, A, Rossor, M, Rothstein, J, Scholz, Sw, Snowden, J, Stephan, Da, Toulson, G, Turner, Mr, Warren, Jd, Young, K, Weng, Yh, Kuo, Hc, Lai, Sc, Huang, Cl, Camuzat, A, Entraingues, L, Guillot, Noël, Verpillat, P, Blanc, F, Camu, W, Clerget Darpoux, F, Corcia, P, Couratier, P, Didic, M, Dubois, B, Duyckaerts, C, Guedj, E, Golfier, V, Habert, Mo, Hannequin, D, Lacomblez, L, Meininger, V, Salachas, F, Levy, R, Michel, Bf, Pasquier, F, Puel, M, Thomas Anterion, C, Sellal, F, Vercelletto, M, Moglia, C, Cammarosano, S, Canosa, A, Gallo, S, Brunetti, M, Ossola, I, Marinou, K, Papetti, L, Pisano, F, Pinter, Gl, Conte, A, Luigetti, M, Zollino, M, Lattante, S, Marangi, G, la Bella, V, Spataro, R, Colletti, T, Battistini, S, Ricci, C, Caponnetto, C, Mancardi, G, Mandich, P, Salvi, F, Bartolomei, I, Mandrioli, J, Sola, P, Lunetta, C, Penco, S, Monsurro', Maria Rosaria, Tedeschi, Gioacchino, Conforti, Fl, Gambardella, A, Quattrone, A, Volanti, P, Floris, G, Cannas, A, Piras, V, Marrosu, F, Marrosu, Mg, Murru, Mr, Pugliatti, M, Parish, Ld, Sotgiu, A, Solinas, G, Ulgheri, L, Ticca, A, Simone, I, Logroscino, G, Hernandez, Dg, Arepalli, S, Sabatelli, M, Mora, G, Corbo, M, Giannini, F, Calvo, A, Englund, E, Borghero, G, Floris, Gl, Remes, Am, Laaksovirta, H, Mccluskey, L, Trojanowski, Jq, Van Deerlin, Vm, Schellenberg, Gd, Nalls, Ma, Drory, Ve, Lu, C, Yeh, Th, Ishiura, H, Takahashi, Y, Tsuji, S, Le Ber, I, Brice, A, Drepper, C, Williams, N, Kirby, J, Shaw, P, Hardy, J, Tienari, Pj, Heutink, P, Morris, Hr, Pickering Brown, S, and Traynor, Bj

Published
2012

177. Large proportion of amyotrophic lateral sclerosis cases in Sardinia due to a single founder mutation of the TARDBP gene

Author

Chiò A, Borghero G, Pugliatti M, Ticca A, Calvo A, Moglia C, Mutani R, Brunetti M, Ossola I, Marrosu MG, Murru MR, Floris G, Cannas A, Parish LD, Cossu P, Abramzon Y, Johnson JO, Nalls MA, Arepalli S, Chong S, Hernandez DG, Traynor BJ, Restagno G, Battistini S, Giannini F, Ricci C, Canosa A, Gallo S, Mandrioli J, Sola P, Salvi F, Bartolomei I, Mora G, Marinou K, Papetti L, Conte A, Sabatelli M, Luigetti M, Spataro R, La Bella V, Paladino P, Caponnetto C, Volanti P., MONSURRO', Maria Rosaria, TEDESCHI, Gioacchino, Chiò, A, Borghero, G, Pugliatti, M, Ticca, A, Calvo, A, Moglia, C, Mutani, R, Brunetti, M, Ossola, I, Marrosu, Mg, Murru, Mr, Floris, G, Cannas, A, Parish, Ld, Cossu, P, Abramzon, Y, Johnson, Jo, Nalls, Ma, Arepalli, S, Chong, S, Hernandez, Dg, Traynor, Bj, Restagno, G, Battistini, S, Giannini, F, Ricci, C, Canosa, A, Gallo, S, Monsurro', Maria Rosaria, Tedeschi, Gioacchino, Mandrioli, J, Sola, P, Salvi, F, Bartolomei, I, Mora, G, Marinou, K, Papetti, L, Conte, A, Sabatelli, M, Luigetti, M, Spataro, R, La Bella, V, Paladino, P, Caponnetto, C, and Volanti, P.

Subjects
Male, Threonine, Genotype, DNA Mutational Analysis, Mutation, Missense, Biology, medicine.disease_cause, Article, Degenerative disease, Superoxide Dismutase-1, Arts and Humanities (miscellaneous), medicine, Humans, Genetic Predisposition to Disease, Prospective Studies, Amyotrophic lateral sclerosis, Gene, Aged, Genetics, Mutation, Alanine, Superoxide Dismutase, Amyotrophic Lateral Sclerosis, Case-control study, Middle Aged, medicine.disease, Founder Effect, DNA-Binding Proteins, Phenotype, Amino Acid Substitution, Italy, Case-Control Studies, RNA-Binding Protein FUS, Female, Neurology (clinical), Genetic isolate, Founder effect
Abstract

To perform an extensive screening for mutations of amyotrophic lateral sclerosis (ALS)-related genes in a consecutive cohort of Sardinian patients, a genetic isolate phylogenically distinct from other European populations.Population-based, prospective cohort study.A total of 135 Sardinian patients with ALS and 156 healthy control subjects of Sardinian origin who were age- and sex-matched to patients.Patients underwent mutational analysis for SOD1, FUS, and TARDBP.Mutational screening of the entire cohort found that 39 patients (28.7%) carried the c.1144GA (p.A382T) missense mutation of the TARDBP gene. Of these, 15 had familial ALS (belonging to 10 distinct pedigrees) and 24 had apparently sporadic ALS. None of the 156 age-, sex-, and ethnicity-matched controls carried the pathogenic variant. Genotype data obtained for 5 ALS cases carrying the p.A382T mutation found that they shared a 94-single-nucleotide polymorphism risk haplotype that spanned 663 Kb across the TARDBP locus on chromosome 1p36.22. Three patients with ALS who carry the p.A382T mutation developed extrapyramidal symptoms several years after their initial presentation with motor weakness.The TARDBP p.A382T missense mutation accounts for approximately one-third of all ALS cases in this island population. These patients share a large risk haplotype across the TARDBP locus, indicating that they have a common ancestor.

Published
2011

178. A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

Author

Renton, Ae, Majounie, E, Waite, A, Simón Sánchez, J, Rollinson, S, Gibbs, Jr, Schymick, Jc, Laaksovirta, H, van Swieten, Jc, Myllykangas, L, Kalimo, H, Paetau, A, Abramzon, Y, Remes, Am, Kaganovich, A, Scholz, Sw, Duckworth, J, Ding, J, Harmer, Dw, Hernandez, Dg, Johnson, Jo, Mok, K, Ryten, M, Trabzuni, D, Guerreiro, Rj, Orrell, Rw, Neal, J, Murray, A, Pearson, J, Jansen, Ie, Sondervan, D, Seelaar, H, Blake, D, Young, K, Halliwell, N, Callister, Jb, Toulson, G, Richardson, A, Gerhard, A, Snowden, J, Mann, D, Neary, D, Nalls, Ma, Peuralinna, T, Jansson, L, Isoviita, Vm, Kaivorinne, Al, Hölttä Vuori, M, Ikonen, E, Sulkava, R, Benatar, M, Wuu, J, Chiò, A, Restagno, G, Borghero, G, Sabatelli, M, Italsgen, Consortium, Heckerman, D, Rogaeva, E, Zinman, L, Rothstein, Jd, Sendtner, M, Drepper, C, Eichler, Ee, Alkan, C, Abdullaev, Z, Pack, Sd, Dutra, A, Pak, E, Hardy, J, Singleton, A, Williams, Nm, Heutink, P, Pickering Brown, S, Morris, Hr, Tienari, Pj, Traynor, Bj, Calvo, A, Cammarosano, S, Moglia, C, Canosa, A, Gallo, S, Brunetti, M, Ossola, I, Mora, G, Marinou, K, Papetti, L, Conte, A, Luigetti, M, La Bella, V, Spataro, R, Colletti, T, Battistini, S, Giannini, Fabio, Ricci, C, Caponnetto, C, Mancardi, G, Mandich, P, Salvi, F, Bartolomei, I, Mandrioli, J, Sola, P, Corbo, M, Lunetta, C, Penco, S, Monsurrò, Mr, Tedeschi, G, Conforti, Fl, Volanti, P, Floris, G, Cannas, A, Piras, V, Murru, Mr, Marrosu, Mg, Pugliatti, M, Ticca, A, Simone, I, Logroscino, G, Neuroscience Campus Amsterdam - Systems Biology of the Synapse, Neuroscience Campus Amsterdam - Neurodegeneration, Renton, Ae, Majounie, E, Waite, A, Simón Sánchez, J, Rollinson, S, Gibbs, Jr, Schymick, Jc, Laaksovirta, H, van Swieten, Jc, Myllykangas, L, Kalimo, H, Paetau, A, Abramzon, Y, Remes, Am, Kaganovich, A, Scholz, Sw, Duckworth, J, Ding, J, Harmer, Dw, Hernandez, Dg, Johnson, Jo, Mok, K, Ryten, M, Trabzuni, D, Guerreiro, Rj, Orrell, Rw, Neal, J, Murray, A, Pearson, J, Jansen, Ie, Sondervan, D, Seelaar, H, Blake, D, Young, K, Halliwell, N, Callister, Jb, Toulson, G, Richardson, A, Gerhard, A, Snowden, J, Mann, D, Neary, D, Nalls, Ma, Peuralinna, T, Jansson, L, Isoviita, Vm, Kaivorinne, Al, Hölttä Vuori, M, Ikonen, E, Sulkava, R, Benatar, M, Wuu, J, Chiò, A, Restagno, G, Borghero, G, Sabatelli, M, Italsgen, Consortium, Heckerman, D, Rogaeva, E, Zinman, L, Rothstein, Jd, Sendtner, M, Drepper, C, Eichler, Ee, Alkan, C, Abdullaev, Z, Pack, Sd, Dutra, A, Pak, E, Hardy, J, Singleton, A, Williams, Nm, Heutink, P, Pickering Brown, S, Morris, Hr, Tienari, Pj, COLLABORATORS: Calvo A, Traynor B. J., Cammarosano, S, Moglia, C, Canosa, A, Gallo, S, Brunetti, M, Ossola, I, Mora, G, Marinou, K, Papetti, L, Conte, A, Luigetti, M, La Bella, V, Spataro, R, Colletti, T, Battistini, S, Giannini, F, Ricci, C, Caponnetto, C, Mancardi, G, Mandich, P, Salvi, F, Bartolomei, I, Mandrioli, J, Sola, P, Corbo, M, Lunetta, C, Penco, S, Monsurro', Maria Rosaria, Tedeschi, Gioacchino, Conforti, Fl, Volanti, P, Floris, G, Cannas, A, Piras, V, Murru, Mr, Marrosu, Mg, Pugliatti, M, Ticca, A, Simone, I, Logroscino, G., Neurology, Human genetics, NCA - Systems Biology of the Synapse, and NCA - Neurodegeneration

Subjects
Male, Genotype, Neuroscience(all), Population, Biology, TARDBP, Chromosomes, 03 medical and health sciences, 0302 clinical medicine, Alleles, Amyotrophic Lateral Sclerosis, genetics, Chromosomes, Human, Pair 9, Female, Finland, Frontotemporal Dementia, genetics, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Male, Microsatellite Repeats, Pedigree, Polymorphism, Single Nucleotide, SDG 3 - Good Health and Well-being, C9orf72, Humans, genetics, Genetic Predisposition to Disease, Polymorphism, education, Alleles, Finland, 030304 developmental biology, Genetics, 0303 health sciences, education.field_of_study, General Neuroscience, Haplotype, Amyotrophic Lateral Sclerosis, Charged multivesicular body protein 2B, DNA Repeat Expansion, 3. Good health, Pedigree, C9orf72 Protein, Haplotypes, Frontotemporal Dementia, Female, Trinucleotide repeat expansion, 030217 neurology & neurosurgery, Pair 9, Microsatellite Repeats
Abstract

The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) locus contains one of the last major unidentified autosomal-dominant genes underlying these common neurodegenerative diseases. We have previously shown that a founder haplotype, covering the MOBKL2b, IFNK, and C9ORF72 genes, is present in the majority of cases linked to this region. Here we show that there is a large hexanucleotide (GGGGCC) repeat expansion in the first intron of C9ORF72 on the affected haplotype. This repeat expansion segregates perfectly with disease in the Finnish population, underlying 46.0% of familial ALS and 21.1% of sporadic ALS in that population. Taken together with the D90A SOD1 mutation, 87% of familial ALS in Finland is now explained by a simple monogenic cause. The repeat expansion is also present in one-third of familial ALS cases of outbred European descent, making it the most common genetic cause of these fatal neurodegenerative diseases identified to date. © 2011 Elsevier Inc.

Published
2011
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179. Infections by carbapenem-resistant Klebsiella pneumoniae in SCT recipients: a nationwide retrospective survey from Italy

Author

Girmenia, C, Rossolini, Gm, Piciocchi, A, Bertaina, A, Pisapia, G, Pastore, D, Sica, S, Severino, A, Cudillo, L, Ciceri, F, Scimè, R, Lombardini, L, Viscoli, C, Rambaldi, A, the Gruppo Italiano Trapianto Midollo Osseo (GITMO), Frigeni, M, Corti, C, Mometto, G, Annaloro, C, Casari, E, Castagna, L, Rossi, G, Cattaneo, C, Russo, D, Cancelli, V, Alessandrino, Ep, Ripamonti, F, Pavan, F, Rovelli, A, Pecoraro, C, Busca, A, Carraro, F, Fagioli, F, Gallo, S, Caravelli, D, De Gobbi, M, Saglio, G, Castellino, C, Mordini, N, Gaidano, G, Nassi, L, Raimondi, R, Vespignani, M, Scattolin, Am, Panizzolo, Is, Cesaro, S, Candoni, A, Patriarca, F, Bacigalupo, A, Raiola, A, Castagnola, E, Lanino, E, Stanzani, M, Bandini, G, Massaccesi, E, Prete, A, Bassi, S, Vallisa, D, Caramatti, C, Aversa, F, Zuffa, E, Guidi, S, Bosi, A, Tintori, V, Iori, Ap, Capria, S, Arcese, W, Dentamaro, T, Fabritiis, Pd, Anaclerico, B, Chierichini, A, Piedimonte, M, Ferrari, A, Marchesi, F, Mengarelli, A, Cerchiara, E, Tirindelli, Mc, Gaziev, J, Majolino, I, Chiusolo, P, Lucarelli, B, Massei, Ms, Carotti, A, Perruccio, K, Caniglia, M, Santarone, S, Bartolomeo, Pd, Mazzotta, S, Galieni, P, Olivieri, A, Rosa, Gd, Risitano, A, Delia, M, Specchia, G, Palazzo, G, Messina, G, Irrera, G, Angelucci, E, Baronciani, D, Vacca, A, Crescimanno, A, Musso, M, Imbriani, A, Milone, G., Girmenia, C, Rossolini, Gm, Piciocchi, A, Bertaina, A, Pisapia, G, Pastore, D, Sica, S, Severino, A, Cudillo, L, Ciceri, Fabio, Scime, R, Lombardini, L, Viscoli, C, Rambaldi, A, and and the Gruppo Italiano Trapianto Midollo Osseo, (GITMO)

Subjects
Male, Klebsiella pneumoniae, Carbapenem resistant Klebsiella pneumoniae, Drug Resistance, carbapenem-resistant Klebsiella pneumoniae, colonization, sepsis, Allogeneic Hematopoietic Stem Cell Transplantation, Hematologic Diseases, hemic and lymphatic diseases, polycyclic compounds, Medicine, Adolescent, Adult, Aged, Allografts, Autografts, Female, Humans, Italy, Klebsiella Infections, Middle Aged, Retrospective Studies, Carbapenems, Drug Resistance, Bacterial, Stem Cell Transplantation, Hematology, Transplantation, biology, Bacterial, humanities, surgical procedures, operative, medicine.medical_specialty, Retrospective survey, Internal medicine, business.industry, Retrospective cohort study, Klebsiella infections, biology.organism_classification, Settore MED/15, infection, body regions, Settore MED/15 - MALATTIE DEL SANGUE, Immunology, business
Abstract

Infections by carbapenem-resistant Klebsiella pneumoniae (CRKp) represent a challenging problem after SCT. A retrospective survey (January 2010 to July 2013) involving 52 Italian centers was performed to assess the epidemiology and the prognostic factors of CRKp infections in auto- and allo-SCT. Cases of CRKp infection were reported in 53.4% of centers. CRKp infections were documented in 25 auto-SCTs and 87 allo-SCTs, with an incidence of 0.4% (from 0.1% in 2010 to 0.7% in 2013) and 2% (from 0.4% in 2010 to 2.9% in 2013), respectively. A CRKp colonization documented before or after transplant was followed by an infection in 25.8% of auto-SCT and 39.2% of allo-SCT patients. The infection-related mortality rates were 16% and 64.4%, respectively. A pre-transplant CRKp infection (hazard ratio (HR) 0.33, 95% confidence intervals (CIs) 0.15-0.74; P = 0.007) and a not CRKp-targeted first-line treatment (HR 2.67, 95% CI 1.43-4.99; P = 0.002) were independent factors associated with an increased mortality in allo-SCT patients who developed a CRKp infection. Our study shows challenging findings of CRKp infections in SCT patients in Italy particularly after allo-SCT. The detection of carriers and the definition of early therapeutic strategies represent critical aspects of the management of CRKp infections after SCT. OI Aversa, Franco/0000-0002-8871-6817; de Fabritiis, Paolo/0000-0002-1835-0581; TIRINDELLI, MARIA CRISTINA/0000-0003-4645-4465; cudillo, laura/0000-0002-6828-9707

Published
2015

183. Dosimetria ESR con alanina per adronterapia per protoni e ioni carbonio

Author

Carlino, A., Gallo, S., Marrale, M., Brai, M., Longo, A., Panzeca, S., Bolsi, A., Goma, C., Hrbacek, J., Kramer, M., La Tessa, C., Lomax, T., Scifoni, E., and Durante, M.

Subjects
ESR, EPR, Dosimetria, Protoni, ioni carbonio, PSI, GSI, Settore FIS/01 - Fisica Sperimentale, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Published
2014

184. Caratterizzazione dosimetrica della facility a neutroni termici del reattore TRIGA di Pavia: studio della dose da fotoni mediante rivelatori ESR

Author

Protti, N., Ferrari, M., Ballarini, F., Bortolussi, S., Carante, M., De Bari, A., Giroletti, E., Postuma, I., Gallo, S., Marrale, M., Longo, A., Panzeca, S., Iacoviello, G., and Altieri, S.

Subjects
Settore ING-IND/18 - Fisica Dei Reattori Nucleari, Settore FIS/01 - Fisica Sperimentale, ESR, alanina, neutroni, attivazione, grafite, Monte Carlo, campo misto, Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Published
2014

187. Le leve discriminanti della soddisfazione: il caso Sepsa

Author

ARIA, MASSIMO, SICILIANO, ROBERTA, Gallo, S., Murolo, A., VICHI MAURIZIO, Aria, Massimo, Siciliano, Roberta, Gallo, S., Murolo, F., and Murolo, A.

Subjects
Segmentazione binaria, Tree-based model, Customer Satisfaction, leve discriminanti, Segmentazione Two-Stage, Trasporto Pubblico Locale, Analisi Discriminante
Abstract

Le analisi mirate alla misurazione della soddisfazione dell’utenza del Trasporto Pubblico Locale sono oggi diventate uno strumento di riferimento per gli attori interessati al sistema trasporto. Nel presente lavoro si propone una metodologia per la misurazione della customer satisfaction basata sull’impiego di una strategia di modelli non parametrici quali gli alberi di segmentazione e le tecniche fattoriali discriminanti. Questo approccio consente di individuare i pesi delle differenti leve determinanti il livello di soddisfazione, e di rappresentare i contributi delle dimensioni alla formazione dello stesso, attraverso una rappresentazione intuitiva ed al contempo ampiamente informativa, il “rombo della soddisfazione”. La metodologia è illustrata attraverso un’analisi di customer condotta nell’ambito dei servizi di trasporto erogati dalla società SEPSA Spa, che rappresenta una delle realtà di maggior rilievo del sistema di Trasporto Pubblico Locale campano.

Published
2007

189. Creating Digital Learning Objects for Use in Large Lecture Classes

Author

Human Nutrition, Foods, and Exercise, University Libraries, Walz, Anita R., Good, Deborah J., Baab, Lujean, Gallo, S., Akers, J., Hu, Deyu, Human Nutrition, Foods, and Exercise, University Libraries, Walz, Anita R., Good, Deborah J., Baab, Lujean, Gallo, S., Akers, J., and Hu, Deyu

Abstract

Large lecture classes sometimes fail to provide an informal approach for students to “practice” what they’ve learned, or delve deeper into materials that are not in the textbook. There is currently no textbook that addresses the systematic study of micronutrients, and therefore, researchers from Virginia Tech, James Madison and George Mason Universities are developing a freely accessible online Digital Learning Object (DLO) for the study of micronutrients in body systems. Links to scientific research articles, government Dietary Reference Intakes and other web-based factual information will be provided through the DLO. Undergraduate and graduate students enrolled in vitamins and minerals courses across three institutions will serve as the control group (no exposure to DLO) in 2014 and treatment groups (exposure to DLO) in 2015. The presentation will address the design of the DLO and provide results from year one regarding learning styles and student interest in and perceived utility of DLOs. The discussion will address how to begin developing a DLO, and how it can address learning objectives in large classrooms. As a DLO can be applied to various subjects, this session will be of interest to faculty from many disciplines, as well as instructional designers and administrators.

Published
2016

196. Endoscopic Endonasal transpterygoid transmaxillary approach to the infra temporal and upper parapharyngeal tumors

Author

Battaglia, Paolo, Turri Zanoni, M., Dallan, I., Gallo, S., Sica, E., Padoan, G., Castelnuovo, PAOLO GIOCONDO MARIA, and TURRI ZANONI, Mario

Subjects
Male, endoscopic endonasal, Pterygopalatine Fossa, Contrast Media, infratemporal fossa, Cohort Studies, parapharyngeal space, Parapharyngeal space, Child, Aged, 80 and over, Brain Neoplasms, Infratemporal fossa, Maxillary Sinus, Middle Aged, Prognosis, Angiofibromas, Magnetic Resonance Imaging, Temporal Lobe, internal carotid artery, skull base tumor, medicine.anatomical_structure, Treatment Outcome, Adenocarcinoma, Female, Nasal Cavity, Adult, Natural Orifice Endoscopic Surgery, medicine.medical_specialty, Adolescent, Risk Assessment, Skull Base Neoplasms, Hemangioma, Young Adult, Mucoepidermoid carcinoma, medicine, Carcinoma, Humans, Minimally Invasive Surgical Procedures, Aged, Retrospective Studies, business.industry, Nasopharyngeal Neoplasms, medicine.disease, Survival Analysis, Surgery, Otorhinolaryngology, Chondrosarcoma, business
Abstract

To describe the endoscopic transnasal approach to the infratemporal fossa (ITF) and upper parapharyngeal space (UPS) and to analyze the indications and outcomes of this surgical technique in the management of the tumors localized in this critical area.Case series with chart review.Tertiary-care referral center.Retrospective review of patients with benign and malignant tumors arising in or extending to the ITF and UPS, treated from 2002 to 2012 at a single institute. The tumors were surgically resected using an endoscopic endonasal transpterygoid transmaxillary approach.Thirty-seven consecutive patients with benign tumors (20 juvenile nasopharyngeal angiofibromas, 2 extracranial trigeminal Schwannomas, 2 meningiomas, 1 cavernous hemangioma) and nonmetastatic malignant tumors (2 adenoid-cystic carcinoma, 1 mucoepidermoid carcinoma, 1 squamous cell carcinoma, 1 adenocarcinoma, 1 recurrence of chondrosarcoma, and 6 recurrences of undifferentiated carcinoma of nasopharyngeal type) were treated with curative intent. A gross-total resection was achieved in 35 of 37 patients. Major complications were observed in 1 case (intraoperative internal carotid artery blowout). Postoperatively, 8 patients received some form of adjuvant treatment. Mean follow-up was 30 months for malignancies and 60 months for benign tumors. All patients are now alive without recurrences. Stable intracranial persistence of disease was reported in 2 cases (1 meningioma and 1 adenoid-cystic carcinoma).The purely endoscopic endonasal technique may provide a minimally invasive and safe approach to radically resect selected tumors involving the ITF and UPS. Larger case series and longer follow-up are needed to validate the reproducibility and efficacy of this technique.

Published
2014

198. Il tempo di Santoro

Author

Gallo, S

Subjects
arte astratta secondo novecento, Incisione, Scultura, Pittura, arte astratta secondo novecento, Pittura, Settore L-ART/03 - Storia dell'Arte Contemporanea, Scultura
Published
2014

200. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis

Author

Johnson, J. O., Pioro, E. P., Boehringer, A., Chia, R., Feit, H., Renton, A. E., Pliner, H. A., Abramzon, Y., Marangi, G., Winborn, B. J., Gibbs, J. R., Nalls, M. A., Morgan, S., Shoai, M., Hardy, J., Pittman, A., Orrell, R. W., Malaspina, A., Sidle, K. C., Fratta, P., Harms, M. B., Baloh, R. H., Pestronk, A., Weihl, C. C., Rogaeva, E., Zinman, L., Drory, V. E., Borghero, G., Mora, G., Calvo, A., Rothstein, J. D., Drepper, C., Sendtner, M., Singleton, A. B., Taylor, J. P., Cookson, M. R., Restagno, G., Sabatelli, M., Bowser, R., Chio`, A., Traynor, B. J., Moglia, C., Cammarosano, S., Canosa, A., Gallo, S., Brunetti, M., Ossola, I., Marinou, K., Papetti, L., Pisano, F., Pinter, G. L., Conte, A., Luigetti, M., Zollino, M., Lattante, S., la Bella, V., Spataro, R., Colletti, T., Battistini, S., Ricci, C., Caponnetto, C., Mancardi, G., Mandich, P., Salvi, F., Bartolomei, I., Mandrioli, J., Sola, P., Lunetta, C., Penco, S., Monsurro, M. R., Conforti, F. L., Tedeschi, G., Gambardella, A., Quattrone, A., Volanti, P., Floris, G., Cannas, A., Piras, V., Marrosu, F., Marrosu, M. G., Murru, M. R., Pugliatti, M., Parish, L. D., Sotgiu, A., Solinas, G., Ulgheri, L., Ticca, A., Simone, I., Logroscino, G., Pirisi, A., Johnson, JO, Pioro, EP, Boehringer, A, Chia, R, Feit, H5, Renton, AE, Pliner, HA, Abramzon, Y6, Marangi, G, Winborn, BJ, Gibbs, JR, Nalls, MA, Morgan, S, Shoai, M, Hardy, J, Pittman, A, Orrell, RW, Malaspina, A, Sidle, KC, Fratta, P, Harms, MB, Baloh, RH, Pestronk, A, Weihl, CC, Rogaeva, E, Zinman, L, Drory, VE, Borghero, G, Mora, G, Calvo, A, Rothstein, JD, ITALSGEN Consortium (including Cammarosano,S, Canosa, A, Moglia, C), Drepper, C, Sendtner, M, Singleton, AB, Taylor, JP, Cookson, MR, Restagno, G, Sabatelli, M, Bowser, R, Chiò, A, Traynor, BJ., Moglia, C., Canosa, A., Johnson, Jo, Pioro, Ep, Feit, H, Renton, Ae, Pliner, Ha, Abramzon, Y, Winborn, Bj, Gibbs, Jr, Nalls, Ma, Orrell, Rw, Sidle, Kc, Harms, Mb, Baloh, Rh, Weihl, Cc, Drory, Ve, Rothstein, Jd, Italsgen, Consortium, Among the, Collaborator, Monsurro', Maria Rosaria, Tedeschi, Gioacchino, Singleton, Ab, Taylor, Jp, Cookson, Mr, and Traynor, B. J.

Subjects
Male, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, genetics/pathology, Computational Biology, DNA Mutational Analysis, DNA-Binding Proteins, metabolism, Family Health, Female, Genetic Predisposition to Disease, genetics, Genotype, Humans, Male, Middle Aged, Muscle, Skeletal, metabolism/pathology, Mutation, genetics, Neurologic Examination, Nuclear Matrix-Associated Proteins, genetics/metabolism, RNA-Binding Proteins, genetics/metabolism, Spinal Cord, metabolism/pathology, DNA Mutational Analysis, genetics/metabolism, RNA-binding protein, Settore MED/03 - GENETICA MEDICA, medicine.disease_cause, 0302 clinical medicine, Nuclear Matrix-Associated Proteins, Genotype, 80 and over, genetics, Amyotrophic lateral sclerosis, Exome sequencing, Genetics, Aged, 80 and over, Neurologic Examination, 0303 health sciences, Mutation, General Neuroscience, RNA-Binding Proteins, Middle Aged, DNA-Binding Proteins, MATR3, medicine.anatomical_structure, Spinal Cord, familial amyotrophic lateral sclerosis, Muscle, Settore MED/26 - Neurologia, Female, Frontotemporal dementia, Article, 03 medical and health sciences, mental disorders, medicine, Humans, Genetic Predisposition to Disease, Muscle, Skeletal, 030304 developmental biology, Aged, Family Health, business.industry, Amyotrophic Lateral Sclerosis, genetics/pathology, RNA, Computational Biology, Spinal cord, medicine.disease, genetic, business, Neuroscience, metabolism, 030217 neurology & neurosurgery
Abstract

MATR3 is an RNA- and DNA-binding protein that interacts with TDP-43, a disease protein linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Using exome sequencing, we identified mutations in MATR3 in ALS kindreds. We also observed MATR3 pathology in ALS-affected spinal cords with and without MATR3 mutations. Our data provide more evidence supporting the role of aberrant RNA processing in motor neuron degeneration. © 2014 Nature America, Inc. All rights reserved.

Published
2014
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