2,092 results on '"Galletti P."'
Search Results
152. Vitamina D a la admisión y severidad de la enfermedad en pacientes con COVID-19 en la Unidad de Cuidados Intensivos
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Victoria Gonzalez, Cayetano Galletti, Romina Alvarez Vizzoni, Yanina Saldivar, Nicolás Kessler, Francisco Irades, Estefanía Minoldo, Pablo Calcagno, Antonella Aliscioni, and Ursula Zaya
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enfermedad Coronavirus 2019 ,Vitamina D ,ventilación mecánica ,unidad de cuidados intensivos ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Introducción: La 25-hidroxivitamina D (25(OH)D) disminuiría la incidencia de infecciones respiratorias virales, por su efecto pleiotrópico en la inmunomodulación. Objetivo: evaluamos la influencia de la deficiencia severa de 25(OH)D con la severidad de la enfermedad COVID-19. Métodos: estudio retrospectivo observacional, que incluyó 164 pacientes con diagnóstico de COVID-19 ingresados a la unidad de cuidados intensivos que tuvieran valores plasmáticos de 25(OH)D las primeras 72 horas de internación. Resultados: exhibieron deficiencia de 25(OH)D (
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- 2023
153. Ultrasound Features of Adhesive Capsulitis
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Stella, Salvatore Massimo, Gualtierotti, Roberta, Ciampi, Barbara, Trentanni, Cesare, Sconfienza, Luca Maria, Del Chiaro, Andrea, Pacini, Patrizia, Miccoli, Mario, and Galletti, Stefano
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- 2022
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154. SARS-CoV-2 in a Neonate with Truncus Arteriosus: Management and Surgical Correction Timing
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Masci, M., Moras, P., Di Chiara, L., Pasquini, L., Campanale, C. M., Bagolan, P., Galletti, L., and Toscano, A.
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- 2022
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155. Fungal ball in concha bullosa as incidentaloma: A case report and the review of the literature
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Antonella Spatola, MD, Michele Aspromonte, MD, Maria Adele Marino, MD, Sebastiano Maria Miano, MD, Annamaria Zagaria, MD, Bruno Galletti, MD, Alfredo Blandino, MD, Giorgio Ascenti, MD, and Carmelo Sofia, MD
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Concha bullosa ,Fungal ball ,Incidentaloma ,Computed Tomography ,Pediatrics ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Concha bullosa is an anatomic variant consisting in an enlargement and pneumatization of the middle nasal turbinate. A fungal ball (FB) localized in this structure is an extremely rare disease. This article describes the unusual case of a young patient with an asymptomatic fungal mass in the concha bullosa, incidentally discovered at computed tomography (CT) scan of the head, which was performed after trauma.
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- 2022
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156. Evidence of a topological Hall effect in Eu$_{1-x}$Sm$_x$TiO$_3$
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Ahadi, Kaveh, Galletti, Luca, and Stemmer, Susanne
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Materials Science - Abstract
We report on the observation of a possible topological Hall effect in thin films of the itinerant ferromagnet Eu1-xSmxTiO3. EuTiO3 and Eu0.955Sm0.045TiO3 films were grown by molecular beam epitaxy. The EuTiO3 film is insulating. The Hall resistivity of the Eu0.955Sm0.045TiO3 films exhibits the anomalous Hall effect below the Curie temperature of ~ 5 K as well as additional features that appear at 2 K. It is shown that these features are magnetic in origin and consistent with the topological Hall effect seen in materials systems with topologically nontrivial spin textures, such as skyrmions. The results open up interesting possibilities for epitaxial hybrid heterostructures that combine topological magnetic states, tunable carrier densities, and other phenomena., Comment: Accepted, Appl. Phys. Lett
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- 2017
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157. Ultrasoundhydrodistention in adhesivecapsulitis: Hospital versus home-based rehabilitation.
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Donati, Danilo, Tedeschi, Roberto, Spinnato, Paolo, Pederiva, Davide, Pilla, Federico, Faldini, Cesare, Grazia Benedetti, Maria, Guerra, Enrico, Cavallo, Marco, Miceli, Marco, Galletti, Stefano, and Vita, Fabio
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Adhesive capsulitis, or frozen shoulder, causes pain and reduces glenohumeral joint motion. This study aims to assesses ultrasound-guided hydrodistention with rehabilitation in hospital versus home settings. Forty patients with adhesive capsulitis were split into two groups: one received hydrodistention with hospital-assisted rehabilitation, and the other with home-based rehabilitation, following the same exercise protocol. Clinical assessments included range of motion (ROM), numeric pain rating scale (NPRS), shoulder pain and disability index (SPADI), disability of the arm, shoulder and hand (DASH), and assessment shoulder and elbow scale (ASES) The hospital-based group showed more rapid and substantial improvements in ROM and NPRS scores compared to the home-based group. The hospital-based group had a mean flexion ROM of 104.3 ± 31.6°, which increased to 149.5 ± 20.6° at the final follow-up. The home-based group started with a mean flexion ROM of 103.3 ± 29.2°, improving to 161.3 ± 23.2° by the end of the study. Both groups showed significant improvements, with the home-based group slightly outperforming in flexion ROM by the third follow-up. Initial NPRS scores were 4.7 ± 1.92 for the hospital-based group and 6.6 ± 1.63 for the home-based group. By the six-month mark, the hospital-based group's SPADI score dropped to 17.4 ± 19.5, while the home-based group's score was 10.5 ± 13.03. Both groups demonstrated significant improvements, with the hospital-based group showing slightly better outcomes at various follow-ups. Hydrodistention combined with supervised rehabilitation is optimal for treating frozen shoulder, though home-based therapy is also effective. Both methods significantly benefit from hydrodistention, highlighting its importance in treatment strategies. [ABSTRACT FROM AUTHOR]
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- 2024
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158. Incidence of Bacteriobilia and the Correlation with Antibioticoprophylaxis in Low-Risk Patients Submitted to Elective Videolaparoscopic Cholecystectomy: A Randomized Clinical Trial
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Marcos Alberto Pagani, Pedro Meira Dolfini, Beatriz Flávia de Moraes Trazzi, Maria Ines Meira Dolfini, William Saranholi da Silva, Eduardo Federighi Baisi Chagas, Carlos Henrique Bertoni Reis, João Paulo Galletti Pilon, Bruna Trazzi Pagani, Rodrigo Tavore Strasser, Claudemir Gregório Mendes, Fausto Tucunduva Vernaschi, Daniela Vieira Buchaim, and Rogerio Leone Buchaim
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antibiotic prophylaxis ,bile ,cholelithiasis ,cholecystectomy ,video-assisted surgery ,randomized clinical trial ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Cholelithiasis has a major impact on global health and affects an average of 20% of the Western population. The main risk factors are females, age over 40 years, obesity and pregnancy. Most of the time it is asymptomatic, but when there are symptoms, they are generally nonspecific. Bile was considered sterile, but today it is known that it contains a complex bacterial flora, which causes biofilm in the gallbladder and gallstones. Among the main bacteria associated with cholelithiasis are Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, species of Enterococcus spp. and Acinetobacter spp. Antibiotic prophylaxis is used in an attempt to reduce postoperative infections, especially at the surgical site. However, some authors found no relationship between the use of antibiotic prophylaxis and a lower risk of surgical site infection. Thus, the aim of this double-blind randomized clinical trial was to compare the existence or not of bacteriobilia in patients at low anesthetic risk who underwent videolaparoscopic cholecystectomy, and its correlation with the use of prophylactic antibiotics. This study included 40 patients between 18 and 65 years old, diagnosed with cholelithiasis, symptomatic or not, with low anesthetic risk classified by the American Society of Anesthesiology in ASA I or ASA II, without complications or previous manipulation of the bile duct, who underwent elective video cholecystectomy, divided into two groups: Experimental Group A (n = 20), which received 2 g of Cephalotin (first-generation Cephalosporin, Keflin®, ABL antibiotics, Cosmópolis, Brazil) during anesthetic induction, and Control Group B (n = 20), where no antibiotics were administered until bile collection. After the procedure, a bile sample was collected and culture and antibiogram were performed. In the sample, 22 (55%) were classified as ASA I and 18 (45%) as ASA II. It was observed that 81.8% of the patients who had a positive culture did not use antibiotics, against 18.2% of those who used prophylaxis. When comparing patients regarding anesthetic risk, ASA I patients had a positive culture in 9.1% of cases, against 90.9% in patients classified as ASA II. It was concluded that patients with higher anesthetic risk (ASA II) have a higher chance of bacteriobilia and benefit from antibiotic prophylaxis when compared to patients with lower anesthetic risk (ASA I).
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- 2023
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159. Synthesis of 1-Hexanol/Hexyl hexanoate Mixtures from Grape Pomace: Insights on Diesel Engine Performances at High Bio-Blendstock Loadings
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Stefano Frigo, Anna Maria Raspolli Galletti, Sara Fulignati, Domenico Licursi, Lorenzo Bertin, Gonzalo Agustin Martinez, and Gianluca Pasini
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waste biomass ,rhenium catalyst ,hydrogenation ,oxygenated bio-additives ,exhaust emissions ,Technology - Abstract
The production of oxygenated bio-additives for traditional fuels represents a key challenge due to their depletion in the near-future and their positive contribution to the reduction in environmental pollution. The present study considers the synthesis of 1-hexanol/hexyl hexanoate mixtures, two oxygenated Diesel bio-additives produced through the hydrogenation of hexanoic acid, obtainable from the fermentation of a wide variety of waste biomasses. In our case, crude hexanoic acid was produced through the fermentation of grape pomace, an abundant Italian agrifood waste. Commercial 5 wt% Re/γ-Al2O3 was adopted for the catalytic hydrogenation of crude hexanoic acid, and the support acidity allowed the tuning of the reaction selectivity toward the formation of hexyl hexanoate, instead of 1-hexanol, reaching yields of 40 and 25 mol%, respectively. The effects of each bio-additive on Diesel engine performance and exhaust emissions (soot, nitrogen oxides, carbon monoxide, unburned hydrocarbons) were evaluated, highlighting noteworthy positive effects especially on the reduction in carbon monoxide and soot emissions, if compared with those of Diesel fuel alone. Similar promising performances were achieved by employing Diesel blend mixtures of 1-hexanol/hexyl hexanoate, mimicking typical compositions of the rhenium-catalyzed post-hydrogenation mixtures. Even in such cases, 1-hexanol/hexyl hexanoate mixtures can be blended with commercial Diesel fuel, up to high loadings currently not yet investigated (20 vol%), without altering the engine performances and, again, significantly lowering soot and carbon monoxide emissions by more than 40%. This work highlights the possibility of obtaining such oxygenated bio-additives starting from waste through to a fully sustainable process and proves their beneficial effects on the reduction in exhaust emissions with no changes in engine performance.
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- 2023
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160. Does Vaccine Confidence Mediate the Relationship between Vaccine Literacy and Influenza Vaccination? Exploring Determinants of Vaccination among Staff Members of Nursing Homes in Tuscany, Italy, during the COVID-19 Pandemic
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Francesca Collini, Guglielmo Bonaccorsi, Marco Del Riccio, Mario Bruschi, Silvia Forni, Giacomo Galletti, Fabrizio Gemmi, Francesca Ierardi, and Chiara Lorini
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vaccine literacy ,vaccine confidence ,influenza vaccination ,human influenza ,nursing homes ,mediation model ,Medicine - Abstract
Background: Low coverage of influenza vaccination in nursing home (NH) staff may be attributed to factors such as vaccine confidence (VC) and vaccine literacy (VL). Our study aimed to evaluate the role of VL and VC in predicting the intention to get the influenza vaccine in a sample of employees of NHs in Tuscany, Italy. Methods: Data from staff members in Tuscany were collected using an online questionnaire that examined influenza vaccination history, intentions, demographic information, health status, and VL. Statistical analyses explored the relationships between VC, VL, and vaccination intentions. Results: The study included 1794 respondents, (86.3%) and assistants/aides (58.1%), with a median age of 46 years. The intention to get vaccinated was significantly higher among those with health risk conditions, and there was a positive association between VC and VL, specifically its interactive/critical component. The mediation analysis showed that VC completely mediated the relationship between VL and the intention to get vaccinated, with significant effects observed in different subgroups. Conclusions: VC is a key factor that mediates the effect of VL on vaccine intention. These results suggest that interventions aimed at improving VL alone may not be sufficient to increase vaccine uptake unless VC is also addressed.
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- 2023
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161. Author Correction: Floating macrolitter leaked from Europe into the ocean
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González-Fernández, Daniel, Cózar, Andrés, Hanke, Georg, Viejo, Josué, Morales-Caselles, Carmen, Bakiu, Rigers, Barceló, Damià, Bessa, Filipa, Bruge, Antoine, Cabrera, María, Castro-Jiménez, Javier, Constant, Mel, Crosti, Roberto, Galletti, Yuri, Kideys, Ahmet E., Machitadze, Nino, Pereira de Brito, Joana, Pogojeva, Maria, Ratola, Nuno, Rigueira, Júlia, Rojo-Nieto, Elisa, Savenko, Oksana, Schöneich-Argent, Rosanna I., Siedlewicz, Grzegorz, Suaria, Giuseppe, and Tourgeli, Myrto
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- 2023
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162. Association of uric acid with kidney function and albuminuria: the Uric Acid Right for heArt Health (URRAH) Project
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Russo, Elisa, Viazzi, Francesca, Pontremoli, Roberto, Barbagallo, Carlo Maria, Bombelli, Michele, Casiglia, Edoardo, Cicero, Arrigo Francesco Giuseppe, Cirillo, Massimo, Cirillo, Pietro, Desideri, Giovambattista, D’Elia, Lanfranco, Ferri, Claudio, Galletti, Ferruccio, Gesualdo, Loreto, Giannattasio, Cristina, Iaccarino, Guido, Leoncini, Giovanna, Mallamaci, Francesca, Maloberti, Alessandro, Masi, Stefano, Mengozzi, Alessandro, Mazza, Alberto, Muiesan, Maria Lorenza, Nazzaro, Pietro, Palatini, Paolo, Parati, Gianfranco, Rattazzi, Marcello, Rivasi, Giulia, Salvetti, Massimo, Tikhonoff, Valérie, Tocci, Giuliano, Ungar, Andrea, Verdecchia, Paolo, Virdis, Agostino, Volpe, Massimo, Grassi, Guido, and Borghi, Claudio
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- 2022
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163. Metabolic syndrome and its components predict the development of arterial stiffening in a sample of adult men
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Lanfranco D’Elia, Antonio Barbato, Roberto Iacone, Ornella Russo, Pasquale Strazzullo, and Ferruccio Galletti
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arterial stiffening ,pulse pressure ,metabolic syndrome ,blood pressure ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background and Objective Metabolic syndrome (MS) and its components are associated with greater cardiovascular risk. A number of studies found a positive association between MS and vascular damage, but few observational studies evaluated the predictive role of MS on arterial stiffening (AS). Therefore, the aim of this study was to estimate the ability of MS and its components to predict the risk of AS in an 8-year follow-up of a sample of adult men (Olivetti Heart Study). Methods The analysis included 778 men without AS (pulse pressure >60 mmHg) at baseline. A positive diagnosis of MS was made by recognized criteria, if at least three components were present. Results At the end of the follow-up period, there was an incidence of 11% in AS. The percentage of participants that developed AS was greater in the MS group than those without MS, also after adjustment for main confounders (odds ratio: 2.5, 95% confidence interval: 1.3–4.9). The risk of AS also increased with increase in the numbers of MS elements (p for trend
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- 2022
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164. Music in noise recognition: An EEG study of listening effort in cochlear implant users and normal hearing controls.
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Giulia Cartocci, Bianca Maria Serena Inguscio, Andrea Giorgi, Alessia Vozzi, Carlo Antonio Leone, Rosa Grassia, Walter Di Nardo, Tiziana Di Cesare, Anna Rita Fetoni, Francesco Freni, Francesco Ciodaro, Francesco Galletti, Roberto Albera, Andrea Canale, Lucia Oriella Piccioni, and Fabio Babiloni
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Medicine ,Science - Abstract
Despite the plethora of studies investigating listening effort and the amount of research concerning music perception by cochlear implant (CI) users, the investigation of the influence of background noise on music processing has never been performed. Given the typical speech in noise recognition task for the listening effort assessment, the aim of the present study was to investigate the listening effort during an emotional categorization task on musical pieces with different levels of background noise. The listening effort was investigated, in addition to participants' ratings and performances, using EEG features known to be involved in such phenomenon, that is alpha activity in parietal areas and in the left inferior frontal gyrus (IFG), that includes the Broca's area. Results showed that CI users performed worse than normal hearing (NH) controls in the recognition of the emotional content of the stimuli. Furthermore, when considering the alpha activity corresponding to the listening to signal to noise ratio (SNR) 5 and SNR10 conditions subtracted of the activity while listening to the Quiet condition-ideally removing the emotional content of the music and isolating the difficulty level due to the SNRs- CI users reported higher levels of activity in the parietal alpha and in the homologous of the left IFG in the right hemisphere (F8 EEG channel), in comparison to NH. Finally, a novel suggestion of a particular sensitivity of F8 for SNR-related listening effort in music was provided.
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- 2023
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165. A real opportunity to modify cardiovascular risk through primary care and prevention: A pilot study
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Alberto Lontano, Eleonora Marziali, Caterina Galletti, Eduardo Mazza, Stefano Gambioli, Valerio Galasso, Alessandro Mingarelli, Floriana D'Ambrosio, Andrea Tamburrano, Massimo Paolini, Antonio Bande, Gianfranco Damiani, Chiara de Waure, and Patrizia Laurenti
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cardiovascular disease ,cardiovascular risk score ,risk reduction ,primary care ,primary prevention ,health promotion ,Public aspects of medicine ,RA1-1270 - Abstract
Cardiovascular diseases (CVDs) represent a major threat to health and primary prevention outstands as the most effective instrument to face this issue, addressing multiple risk factors at a time and influencing behavioral patterns. Community nurses have been involved in many interdisciplinary prevention activities, resulting in effective control of CV risk factors. We conducted a pilot study aiming at describing the impact on the CV risk profile of an 18-month interdisciplinary intervention on lifestyle habits. From September 2018 to May 2020, four general practitioners (GPs) working in the Roman neighborhood of Torresina recruited patients having a cardiovascular risk score (CRS) equal to or higher than 3% and lower than 20%; those patients were included in a nutritional, physical, and psychological counseling program. Assessments of patients' health status were led at baseline, 6, 12, and 18 months by a nutritionist, a physiotherapist, a psychologist, their GPs, and a community nurse. The CRS was estimated at every examination, based on the Italian Progetto Cuore algorithm. A total of 76 patients were included (mean age of 54.6 years; 33 men and 43 women). Mean CRS showed a significant reduction between baseline and 12 months (from 4.9 to 3.8); both total cholesterol and systolic blood pressure (SBP) significantly decreased at 6 months of follow-up (respectively, from 211.1 to 192 and from 133.1 to 123.1). Nonetheless, the reduction was later maintained only for SBP. However, during the last 6 months of the intervention, the COVID-19 pandemic broke out, thus, it is not possible to know how much the results achieved at 18 months were influenced by the restrictive measures introduced by the Italian government. When stratifying according to the presence of hypertension/diabetes and physical activity, no differences in the CRS could be highlighted between the two groups. Our pilot study proved that an interdisciplinary counseling intervention program can improve CV risk profile and could be further spread to people that, according to their CRS, would benefit more from changes in lifestyles.
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- 2023
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166. Radiofrequency VS Cold Surgery to Treat Oral Papillomatous Lesions
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Bruno Galletti, Francesco Gazia, Cosimo Galletti, Francesco Freni, Rocco Bruno, Federico Sireci, and Francesco Galletti
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benign neoplasms ,human papilloma virus ,oral cavity ,radio frequency ablation ,Otorhinolaryngology ,RF1-547 - Abstract
Introduction: The aim of this study is to analyse different surgery (radio frequency and cold instrumentation) of oral benign papillomatous lesions. Materials and Methods: A retrospective study was carried out in our section of Otorhinolaryngology from 2014 to 2018. 112 patients with oral benign papillomatous lesions were enrolled and divided into 2 groups. Group A of 62 patients treated with excision of lesions using radio frequency using a bipolar coagulation electrode (CelonLabENT). Group B of 50 patients treated with excision of the lesion using traditional cold instruments (scalpel and surgical forceps). All patients were evaluated for intraoperative bleeding, discomfort and recurrence rate. Results: 112 patients (of which 37 males and 75 females) with mean age 32.9 ranged from 10 to 61 years. The HPV types associated with oral benign papillomatous lesions were HPV 6 (17%), 11 (23,3%), 13 (10,7%), 32 (34%), 2 (10%) and 57 (5%). There are no statistically significant differents among patients operated with radio frequency (Group A) and cold instrumentation (Group B) regarding intraoperative bleeding (P= 0.08), recurrence rate after 1 year from surgery (P=1), intraoperative discomfort (P=0.7) and postoperative discomfort (P=0.6). Conclusion: Radiofrequencies and surgery with scalpel and surgical forceps are equal valid methods for the treatment of benign papillomatous.
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- 2021
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167. Lower visual field preference for the visuomotor control of limb movements in the human dorsomedial parietal cortex
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Maltempo, Teresa, Pitzalis, Sabrina, Bellagamba, Martina, Di Marco, Sara, Fattori, Patrizia, Galati, Gaspare, Galletti, Claudio, and Sulpizio, Valentina
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- 2021
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168. Vision for action: thalamic and cortical inputs to the macaque superior parietal lobule
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Gamberini, Michela, Passarelli, Lauretta, Filippini, Matteo, Fattori, Patrizia, and Galletti, Claudio
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- 2021
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169. Sonographic diagnosis of clinically unsuspected thrombosis of the medial marginal vein and dorsal arch of the foot
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Becciolini, Marco, Galletti, Stefano, Vallone, Gianfranco, Stella, Salvatore Massimo, and Ricci, Vincenzo
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- 2021
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170. Optic flow selectivity in the macaque parieto-occipital sulcus
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Pitzalis, Sabrina, Hadj-Bouziane, Fadila, Dal Bò, Giulia, Guedj, Carole, Strappini, Francesca, Meunier, Martine, Farnè, Alessandro, Fattori, Patrizia, and Galletti, Claudio
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- 2021
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171. Serum leptin is associated with increased pulse pressure and the development of arterial stiffening in adult men: results of an eight-year follow-up study
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D’Elia, Lanfranco, Giaquinto, Alfonso, Iacone, Roberto, Russo, Ornella, Strazzullo, Pasquale, and Galletti, Ferruccio
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- 2021
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172. Observation of the Quantum Hall Effect in Confined Films of the Three-Dimensional Dirac Semimetal Cd3As2
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Schumann, Timo, Galletti, Luca, Kealhofer, David A., Kim, Honggyu, Goyal, Manik, and Stemmer, Susanne
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- 2018
173. Left ventricle dysfunction in patients with critical neonatal pulmonary stenosis: echocardiographic predictors. A single-center retrospective study
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Carolina D’Anna, Alessio Franceschini, Micol Rebonato, Paolo Ciliberti, Claudia Esposito, Roberto Formigari, Maria Giulia Gagliardi, Paolo Guccione, Gianfranco Butera, Lorenzo Galletti, and Marcello Chinali
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Infant ,Catheterization ,Valvuloplasty ,Ventricular interdependence ,Congenital ,Heart disease ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Background The aim of this study is to identify echocardiographic predictors of transient left ventricle dysfunction after pulmonary valve balloon dilatation (PVBD), in neonates with pulmonary valve stenosis (PVS) and atresia with intact septum (PAIVS) at birth. Methods The study includes patients admitted at the Bambino Gesù Children Hospital from January 2012 to January 2017. Clinical, echocardiographic and cardiac catheterization data before and after PVBD were retrospectively analyzed. Results Twenty-nine infants were included in the study (21 male and eight female). The median age was 5.8 ± 7.1 days. Eight patients developed transient LV dysfunction (three PAIVS and five PVS) and comparing data before and after the procedure, there was no difference in right ventricle geometrical and functional parameters except for evidence of at least moderate pulmonary valve regurgitation after PVBD. Conclusion Moderate to severe degree pulmonary valve regurgitation was significant associated to LV dysfunction (p < 0.05) in PVS and PAIVS patients.
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- 2022
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174. LEA: una ricerca europea per diffondere la progettazione condivisa di spazi scolastici. Colegio Italiano a Bogotà: un caso applicativo
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Alessandra Galletti and Beate Weyland
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architettura scolastica ,pedagogia ,partecipazione, progettazione, “Fase 0” ,partecipazione ,progettazione ,“Fase 0” ,Education (General) ,L7-991 ,Science ,Theory and practice of education ,LB5-3640 - Abstract
Architettura e pedagogia hanno un ruolo fondamentale nella definizione dell’identità educativa di una scuola, il Progetto di Ricerca Europeo Learning Environment Applications (LEA), ha come fine la diffusione delle esperienze interdisciplinari partecipative per la progettazione degli spazi scolastici (Woolner, 2018), chiamata nei paesi germanofoni “fase zero”(Weyland, 2018). Nel Progetto LEA sono stati oggetto di indagine vari campi applicativi utili alla diffusione della “Fase 0” (Woolner, 2010); sarà quindi affrontato il tema della progettazione di strumenti (Weyland, 2017) rivolti a personale scolastico, progettisti, amministratori, per standardizzare le attività delle fasi 0 e velocizzare la raccolta delle esigenze dei partecipanti. Infine sarà presentata l’eperienza della fase di test dei prototipi, in un percorso di progettazione condivisa per il ripensamento degli spazi nella Scuola italiana Leonardo da Vinci a Bogotá in Colombia.
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- 2022
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175. Impact of severe valvular heart disease in adult congenital heart disease patients
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Francesca Graziani, Giulia Iannaccone, Maria Chiara Meucci, Rosa Lillo, Angelica Bibiana Delogu, Maria Grandinetti, Gianluigi Perri, Lorenzo Galletti, Antonio Amodeo, Gianfranco Butera, Aurelio Secinaro, Antonella Lombardo, Gaetano Antonio Lanza, Francesco Burzotta, Filippo Crea, and Massimo Massetti
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valvular heart disease ,adult congenital heart disease (ACHD) ,prognosis ,hospitalization ,mortality ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundThe clinical impact of valvular heart disease (VHD) in adult congenital heart disease (ACHD) patients is unascertained. Aim of our study was to assess the prevalence and clinical impact of severe VHD (S-VHD) in a real-world contemporary cohort of ACHD patients.Materials and methodsConsecutive patients followed-up at our ACHD Outpatient Clinic from September 2014 to February 2021 were enrolled. Clinical characteristics and echocardiographic data were prospectively entered into a digitalized medical records database. VHD at the first evaluation was assessed and graded according to VHD guidelines. Clinical data at follow-up were collected. The study endpoint was the occurrence of cardiac mortality and/or unplanned cardiac hospitalization during follow-up.ResultsA total of 390 patients (median age 34 years, 49% males) were included and S-VHD was present in 101 (25.9%) patients. Over a median follow-up time of 26 months (IQR: 12–48), the study composite endpoint occurred in 76 patients (19.5%). The cumulative endpoint-free survival was significantly lower in patients with S-VHD vs. patients with non-severe VHD (Log rank p < 0.001). At multivariable analysis, age and atrial fibrillation at first visit (p = 0.029 and p = 0.006 respectively), lower %Sat O2, higher NYHA class (p = 0.005 for both), lower LVEF (p = 0.008), and S-VHD (p = 0.015) were independently associated to the study endpoint. The likelihood ratio test demonstrated that S-VHD added significant prognostic value (p = 0.017) to a multivariate model including age, severe CHD, atrial fibrillation, %Sat O2, NYHA, LVEF, and right ventricle systolic pressure > 45 mmHg.ConclusionIn ACHD patients, the presence of S-VHD is independently associated with the occurrence of cardiovascular mortality and hospitalization. The prognostic value of S-VHD is incremental above other established prognostic markers.
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- 2022
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176. Trends of blood pressure, raised blood pressure, hypertension and its control among Italian adults: CUORE Project cross-sectional health examination surveys 1998/2008/2018
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Graziano Onder, Luigi Palmieri, Michele Massimo Gulizia, Chiara Donfrancesco, Anna Di Lonardo, Cinzia Lo Noce, Brigitta Buttari, Elisabetta Profumo, Francesca Vespasiano, Serena Vannucchi, Ferruccio Galletti, Daniela Galeone, and Paolo Bellisario
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Medicine - Abstract
Objectives To assess in the Italian general adult population the trends of blood pressure (BP) and prevalence of raised BP (RBP), hypertension and its control in order to evaluate population health and care, and the achievement of an RBP 25% relative reduction as recommended by the WHO at population level.Design Results comparison of health examination surveys, cross-sectional observational studies based on health examination of randomly selected age and sex stratified samples including residents aged 35–74 years. Data of the 2018/2019 survey were compared with the previous ones collected in 1998/2002 and 2008/2012.Setting Health examination surveys conducted in Italy within the CUORE Project following standardised methodologies.Participants 2985 men and 2955 women examined in 1998/2002, 2218 men and 2204 women examined in 2008/2012 and 1031 men and 1066 women examined in 2018/2019.Primary and secondary outcome measures Age-standardised mean of BP, prevalence of RBP (systolic BP and/or diastolic BP ≥140/90 mm Hg), hypertension (presenting or being treated for RBP) and its awareness and control, according to sex, age class and educational level.Results In 2018/2019, a significant reduction was observed in systolic BP and diastolic BP in men (1998/2002: 136/86 mm Hg; 2008/2012: 132/84 mm Hg; and 2018/2019: 132/78 mm Hg) and women (132/82 mm Hg, 126/78 mm Hg and 122/73 mm Hg), and in the prevalence of RBP (50%, 40% and 30% in men and 39%, 25% and 16% in women) and of hypertension (54%, 49% and 44% in men and 45%, 35% and 32% in women). Trends were consistent by age and education attainment. In 2018/2019, hypertensive men and women with controlled BP were only 27% and 41%, but a significant favourable trend was observed.Conclusions Data from 2018/2019 underlined that RBP is still commonly observed in the Italian population aged 35–74 years, however, the WHO RBP target at that time may be considered met.
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- 2022
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177. Effectiveness and Safety Profile of Dupilumab in Chronic Rhinosinusitis with Nasal Polyps: Real-Life Data in Tertiary Care
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Cosimo Galletti, Maria Antonietta Barbieri, Francesco Ciodaro, Francesco Freni, Francesco Galletti, Edoardo Spina, and Bruno Galletti
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dupilumab ,safety profile ,chronic rhinosinusitis with nasal polyps ,real-word evidence ,otorhinolaryngology ,Medicine ,Pharmacy and materia medica ,RS1-441 - Abstract
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a type 2 pattern of inflammation resulting in the production of some cytokines. Dupilumab radically changes the treatment of CRSwNP, but, considering its recent approval, it may be useful to evaluate its safety profile in a real-world setting. This work aimed to prospectively highlight the effectiveness and safety profile of dupilumab in patients with CRSwNP enrolled in the Otorhinolaryngology Unit of the University Hospital of Messina. An observational cohort study was carried out considering all patients treated with dupilumab. A descriptive analysis was conducted reporting all demographic characteristics, endoscopic evaluations, and symptom conditions. A total of 66 patients were treated with dupilumab, but three patients were excluded due to a lack of adherence during the observational period. A statistically significant reduction in the Sino-Nasal Outcome Test 22 (SNOT-22) and nasal polyps score (NPS) was shown at the 6th and 12th months compared to baseline values (SNOT-22, −37 and −50, p < 0.001 for both comparisons; NPS, −3 and −4, p < 0.001 for both comparisons). During the follow-up, eight patients (12.7%) had a reaction at the site of injection, and seven (11.1%) had transient hypereosinophilia. Given the optimal treatment response and the minimal adverse effects observed, clinicians should consider dupilumab a safe and effective treatment. Further studies are necessary to better understand the long-term effects.
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- 2023
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178. Universal newborn hearing screening in the Italian Region of Sicily in 2018
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Salvatore Ferlito, Antonino Maniaci, Salvatore Cocuzza, Ignazio La Mantia, Paola Di Mauro, Graziella Poli, Luigi Maiolino, Salvatore Coco, Federico Merlino, Marina Maltese, Margherita Ragliani, Michele Russo, Alessandro Gulino, Carmen Azieli, Francesco Martines, Francesco Galletti, and Luciano Bubbico
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Otorhinolaryngology ,RF1-547 - Published
- 2021
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179. Reliability of Fetal Echocardiography in Predicting Postnatal Critical Hypoxia in Patients with Transposition of Great Arteries and Intact Ventricular Septum
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Masci, M., Pasquini, L., Alsaied, T., Di Chiara, L., Formigari, R., Galletti, L., Campanale, C. M., Romiti, A., Bonito, M., Bagolan, P., and Toscano, A.
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- 2021
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180. Tracheal trifurcation: new cases and review of the literature
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Santangelo, Teresa Pia, Ottavianelli, Alessandra, Curione, Davide, Casazza, Ines, Viglietti, Daniela, Agati, Salvatore, Galletti, Lorenzo, Tomà, Paolo, and Secinaro, Aurelio
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- 2021
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181. Posture and dysphonia associations in patients undergoing total thyroidectomy: stabilometric analysis
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Bruno, Galletti, Melissa, Sciumè, Natalia, Catalano, Francesco, Gazia, Francesco, Freni, Rocco, Bruno, Patrizia, Longo, Antonella, Pino, Ettore, Caruso, Zhang, Daqi, Gianlorenzo, Dionigi, and Francesco, Galletti
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- 2020
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182. Surgical quadriceps lengthening can reduce quadriceps spasticity in chronic stroke patients. A case-control study
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Andrea Merlo, Martina Galletti, Paolo Zerbinati, Paolo Prati, Francesca Mascioli, Giacomo Basini, Chiara Rambelli, Stefano Masiero, and Davide Mazzoli
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stroke ,spasticity ,surgery ,aponeurectomy ,Modified Tardieu Scale ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
BackgroundMuscle overactivity is one of the positive signs of upper motor neuron lesions. In these patients, the loss of muscle length and extensibility resulting from soft tissue rearrangement has been suggested as a contributing cause of muscle overactivity in response to stretching.ObjectiveTo assess the effects of surgical lengthening of the quadriceps femoris (QF) muscle-tendon unit by aponeurectomy on muscle spasticity.MethodsThis is a case-control study on chronic stroke patients with hemiparesis that have undergone lower limb functional surgery over a 8-year period. CASEs underwent corrective surgery for both the foot and knee deviations, inclusive of a QF aponeurectomy. Controls (CTRLs) underwent corrective surgery for foot deviations only. QF spasticity was assessed with the Modified Tardieu Scale (MTS) before and 1 month after surgery. The Wilcoxon test was used to assess MTS variations over time and the Mann–Whitney test was used to verify the presence of group differences at the 1 month mark.ResultsNinety-three patients were included: 57 cases (30F, 1–34 years from lesion) and 36 controls (12F, 1–35 years from lesion). Before surgery, both CASEs and CTRLs had similar MTS scores (median MTS = 3) and functional characteristics. One month after surgery, QF spasticity was significantly lower in the CASEs compared to CTRLs (p = 0.033) due to a significant reduction of the median MTS score from 3 to 0 in the CASE group (p < 0.001) and no variations in the CTRL group (p = 0.468). About half of the cases attained clinically significant MTS reductions and complete symptom relief even many years from the stroke.ConclusionsFunctional surgery inclusive of QF aponeurectomy can be effective in reducing or suppressing spasticity in chronic stroke patients. This is possibly a result of the reduction in neuromuscular spindle activation due to a decrease in muscle shortening, passive tension, and stiffness.
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- 2022
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183. O medo e o colaboracionismo neoliberal: 'psicologia das massas' do consentimento em tempos sombrios
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Marcelo Galletti Ferretti
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medo ,neoliberalismo ,psicanálise ,trabalho ,Psychology ,BF1-990 - Abstract
Resumo Neste artigo, apresentam-se algumas contribuições para a investigação do medo como motor da colaboração - transformada em colaboracionismo - no neoliberalismo. Para isso, inicialmente, são recuperadas algumas ideias de Christophe Dejours, salientando o papel do trabalho e do medo no funcionamento da máquina neoliberal. Visto que essa visão não contempla algumas questões a respeito da natureza do engajamento produzido na coletividade, retoma-se, em seguida, a análise freudiana da psicologia das massas em busca de respostas. Por fim, após detectar os limites de tal análise, excessivamente centrada na figura do Pai (ou no líder), este estudo recorre a Jacques Lacan com vistas à elaboração de uma nova psicologia das massas mais adequada ao que se parece assistir na atualidade.
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- 2022
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184. Incidence and predictors of pericardial effusion following surgical closure of atrial septal defect in children: A single center experience
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Martina Campisano, Camilla Celani, Alessio Franceschini, Denise Pires Marafon, Silvia Federici, Gianluca Brancaccio, Lorenzo Galletti, Fabrizio De Benedetti, Marcello Chinali, and Antonella Insalaco
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atrial septal defect ,pericardial effusion ,body mass index ,post-pericardiotomy syndrome ,congenital heart disease ,Pediatrics ,RJ1-570 - Abstract
ObjectivesTo evaluate the incidence of pericardial effusion (PE) after surgical atrial septal defect (ASD) closure and to investigate the presence of predictive risk factors for its development.MethodsWe collected data from 203 patients followed at Bambino Gesù Children’s Hospital of Rome who underwent cardiac surgery for ASD repair between January 2015 and September 2019.ResultsA total of 200/203 patients with different types of ASD were included. Patients were divided into two groups: Group 1) 38 (19%) who developed PE and Group 2) 162 (81%) without PE. No differences were noted between the two groups with regard to gender or age at the surgery. Fever in the 48 h after surgery was significantly more frequent in group 1 than in group 2 (23.7 vs. 2.5%; p < 0.0001). ECG at discharge showed significant ST-segment elevation in children who developed PE, 24.3 vs. 2.0% in those who did not (p < 0.0001). Group 1 patients were divided into two subgroups on the basis of the severity of PE, namely, 31 (81.6%) with mild and 7 (18.4%) with moderate/severe PE. Patients with moderate/severe PE had a significantly higher BMI value (median 19.1 Kg/m2) (range 15.9–23.4, p = 0.004).ConclusionThe presence of fever and ST-segment elevation after surgery predicts subsequent development of PE suggesting a closer follow-up for these categories of patients. A higher BMI appears to be associated with a higher risk of moderate/severe PE.
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- 2022
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185. The interplay between serine proteases and caspase-1 regulates the autophagy-mediated secretion of Interleukin-1 beta in human neutrophils
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Irene A. Keitelman, Carolina M. Shiromizu, Nadia R. Zgajnar, Silvia Danielián, Carolina C. Jancic, Marcelo A. Martí, Federico Fuentes, Judith Yancoski, Douglas Vera Aguilar, David A. Rosso, Verónica Goris, Guadalupe Buda, María Martha Katsicas, Mario D. Galigniana, Jeremías G. Galletti, Florencia Sabbione, and Analia S. Trevani
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autophagosome ,granulocytes ,inflammasome ,neutral proteases ,unconventional protein secretion ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Neutrophils play major roles against bacteria and fungi infections not only due to their microbicide properties but also because they release mediators like Interleukin-1 beta (IL-1β) that contribute to orchestrate the inflammatory response. This cytokine is a leaderless protein synthesized in the cytoplasm as a precursor (pro-IL-1β) that is proteolytically processed to its active isoform and released from human neutrophils by secretory autophagy. In most myeloid cells, pro-IL-1β is processed by caspase-1 upon inflammasome activation. Here we employed neutrophils from both healthy donors and patients with a gain-of-function (GOF) NLRP3-mutation to dissect IL-1β processing in these cells. We found that although caspase-1 is required for IL-1β secretion, it undergoes rapid inactivation, and instead, neutrophil serine proteases play a key role in pro-IL-1β processing. Our findings bring to light distinctive features of the regulation of caspase-1 activity in human neutrophils and reveal new molecular mechanisms that control human neutrophil IL-1β secretion.
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- 2022
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186. Changes in the Cath Lab in the Treatment of Adult Patients with Congenital Heart Disease: A 12-Year Experience in a Single Referral Center with the Establishment of a Dedicated Working Group
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Maria Giulia Gagliardi, Roberto Formigari, Marco Alfonso Perrone, Elettra Pomiato, Francesca Fanisio, Mario Panebianco, Rosaria Barracano, Paolo Guccione, Rosalinda Palmieri, Massimiliano Raponi, and Lorenzo Galletti
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adult congenital heart disease ,interventional cardiology ,cardiac catheterization ,ACHD ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Adults with congenital heart disease (ACHD) are a growing population needing ongoing care. The aim of this study was to investigate if a dedicated ACHD team impacted the timing and indication of invasive cardiology procedures in these patients at our hospital. Methods: Our retrospective single-center study enrolled adult patients with moderate or complex congenital heart disease and with at least one cardiac catheterization between January 2010 and December 2021. According to the period, procedures were labeled as group A (2010 to 2015) or group B (2016 to 2021) and further divided into diagnostic (DCC) and interventional cardiac catheterizations (ICC). Results: 594 patients were eligible for the study. Both DCC (p < 0.05) and ICC increased between groups A and B (p < 0.05). In group B: Fontan patients accounted for the majority of DCC (p < 0.001), while DCC decreased in arterial switch repair (p < 0.001). In Fontan patients, conduit stenting was prevalent (p < 0.001), while fenestration closures dropped (p < 0.01). In patients with tetralogy of Fallot and native outflow tract, percutaneous pulmonary valve implantations (PPVI) increased, with a concurrent reduction in pulmonary valve replacements (p < 0.001 vs. surgical series). In right ventricular conduits, ICC increased (p < 0.01), mainly due to PPVI. Among Mustard/Senning patients, baffle stenting increased from Group A to Group B (p < 0.001). In patients with pulmonary atresia and biventricular repair, ICC often increased for pulmonary artery stenting. Conclusions: A dedicated working group could improve ACHD patients’ indications for interventional procedures, leading to tailored treatment, better risk stratification and optimizing time until heart transplantation.
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- 2023
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187. Condemnation of Porcine Carcasses: A Two-Year Long Survey in an Italian High-Throughput Slaughterhouse
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Alfonso Rosamilia, Giorgio Galletti, Stefano Benedetti, Chiara Guarnieri, Andrea Luppi, Stefano Capezzuto, Marco Tamba, Giuseppe Merialdi, and Giuseppe Marruchella
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pigs ,slaughterhouse ,ante-mortem inspection ,post-mortem inspection ,carcass condemnation ,Veterinary medicine ,SF600-1100 - Abstract
Ante-mortem and post-mortem inspection at slaughter are performed by Official Veterinarians and it is essential to identify alterations/lesions, which can make organs/carcasses unsuitable for human consumption. Obviously, carcass condemnation must be regarded as a highly undesirable event for the entire swine industry chain, as it represents the total failure of a long period of challenging work. Therefore, it seems valuable to estimate the prevalence and causes of carcasses condemnation, in order to preserve consumers’ health and pig farming profitability. Bearing that in mind, the present study aimed at providing a reliable picture of the condemnation of porcine carcasses in Italy, with a special emphasis being placed upon pathological findings. Data were collected in a high-throughput abattoir located in northern Italy, where a total of 2,062,278 pigs were slaughtered during the period of study (2021–2022). Overall, 1362 pigs were considered unfit for slaughtering after ante-mortem inspection, mostly because of death during transportation or in resting pens, after their arrival at the abattoir. Moreover, 2007 carcasses were condemned after post-mortem inspection. The most common causes of condemnation were severe and diffuse peritonitis, disseminated abscesses, jaundice, and erysipelas. In our opinion, the present survey may provide useful and updated information about the condemnation of pig carcasses in Italy. At the same time, it highlights the need to collect data in a more systematic and standardized way, thus making possible their comparison over time and among different geographic areas.
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- 2023
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188. Paratuberculosis, Animal Welfare and Biosecurity: A Survey in 33 Northern Italy Dairy Goat Farms
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Alessandra Gaffuri, Filippo Barsi, Edoardo Magni, Stefania Bergagna, Debora Dellamaria, Matteo Ricchi, Livia De Paolis, Giorgio Galletti, Norma Arrigoni, Valentina Lorenzi, Francesca Fusi, Alice Prosperi, and Chiara Garbarino
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Mycobacterium avium subsp. paratuberculosis ,MAP ,dairy goats ,serology ,biosecurity ,animal welfare assessment ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
Paratuberculosis is a notable infectious disease of ruminants. Goats appear to be particularly susceptible. The survey aimed to investigate the spread of paratuberculosis in Italian goat farming and evaluate whether the presence of the disease could be influenced by welfare and biosecurity deficiencies. A serological survey for paratuberculosis in 33 dairy farms in northern Italy was conducted. Contextually, animal welfare and biosecurity were assessed, using a standardized protocol of 36 welfare indicators and 15 biosecurity indicators which assigns to each farm a welfare and biosecurity score from 0 (any application) to 100% (full application). An overall result of less than 60% was considered insufficient. Nineteen farms (58%) tested positive for paratuberculosis, with a mean intra-herd seroprevalence of 7.4%. Total welfare ranged from 39.56 to 90.7% (mean 68.64%). Biosecurity scores ranged from 10.04 to 90.01% (mean 57.57%). Eight farms (24%) showed poor welfare conditions (welfare score < 60%) and 19 (58%) an unsatisfactory biosecurity condition (biosecurity score < 60%). With respect to the explorative character of the study, an indicative association between seven welfare and biosecurity indicators and paratuberculosis seropositivity was identified. The presence of paratuberculosis in northern Italy dairy goat farms was confirmed. The welfare and biosecurity assessment protocol proved to be an accurate tool, capable of identifying critical points for managing health, welfare and productivity.
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- 2023
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189. Microbial Oil Production from Alkali Pre-Treated Giant Reed (Arundo donax L.) by Selected Fungi
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Stefano Cianchetta, Enrico Ceotto, and Stefania Galletti
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Mortierella isabellina ,Thamnidium elegans ,Cunninghamella echinulata ,biodiesel ,linolenic acid ,Technology - Abstract
This study aimed to evaluate the microbial oil production by three selected strains, Mortierella isabellina, Cunninghamella echinulata, and Thamnidium elegans, after fermentation of an enzymatic hydrolysate from alkali pre-treated giant reed biomass, in comparison to a semi-synthetic medium, at three increasing nitrogen supplementation levels (0.14, 0.25, and 0.47 g/L). M. isabellina showed the fastest sugar consumption, the highest final cell and oil concentrations (10.9 and 5.6 g/L, respectively), as well as the highest cellular oil content, oil yield/g sugar consumed, and oil productivity (63.4%, 0.19 g/g, and 1 g/L/day, respectively) in the giant reed hydrolysate. The oil yield tended to decrease with an increasing nitrogen content in the cultures. Oleic acid was the most copious fatty acid in the oil for all the fungi. On the contrary, T. elegans exhibited the poorest performances. In particular, M. isabellina showed, respectively, the highest and lowest values of oleic and γ-linolenic acid (52.2 and 3.1%, on average). In comparison, C. echinulata and T. elegans showed much higher γ-linolenic acid content (15.3 and 21.6%, on average). Notably, the C. echinulata cultures showed by far the highest γ-linolenic acid concentration in both substrates (345 and 595 g/L in the giant reed hydrolysate and in the synthetic medium, respectively). Finally, the estimated biodiesel properties of all the oils fell within the limits of the U.S. standards, while the oil of M. isabellina only respected the tighter limits fixed by the E.U. regulations.
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- 2023
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190. Ultrasound-Guided Infiltrative Treatment Associated with Early Rehabilitation in Adhesive Capsulitis Developed in Post-COVID-19 Syndrome
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Danilo Donati, Fabio Vita, Roberto Tedeschi, Stefano Galletti, Alessandro Biglia, Tommaso Gistri, Pasquale Arcuri, Flavio Origlio, Francesco Castagnini, Cesare Faldini, Davide Pederiva, and Maria Grazia Benedetti
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ultrasound infiltrative treatment ,early rehabilitation ,adhesive capsulitis ,post-COVID-19 syndrome ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: Post-COVID-19 syndrome is commonly used to describe signs and symptoms that continue or develop after acute COVID-19 for more than 12 weeks. The study aimed to evaluate a treatment strategy in patients with adhesive capsulitis (phase 1) developed in post-COVID-19 syndrome. Materials and Methods: The method used was an interventional pilot study in which 16 vaccinated patients presenting with the clinical and ultrasound features of adhesive capsulitis (phase 1) developed during post-COVID-19 syndrome were treated with infiltrative hydrodistension therapy under ultrasound guidance associated with early rehabilitation treatment. Results: Sixteen patients with post-COVID-19 syndrome treated with ultrasound-guided infiltration and early rehabilitation treatment showed an important improvement in active joint ROM after 10 weeks, especially in shoulder elevation and abduction movements. The VAS mean score before the treatment was 6.9 ± 1.66. After 10 weeks of treatment, the VAS score was 1 ± 0.63. Conclusions: The study demonstrated that the management of adhesive capsulitis (phase 1) developed in post-COVID-19 syndrome, as conducted by physiotherapists in a primary care setting using hydrodistension and a rehabilitation protocol, represented an effective treatment strategy.
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- 2023
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191. Performance of 11 Host Biomarkers Alone or in Combination in the Diagnosis of Late-Onset Sepsis in Hospitalized Neonates: The Prospective EMERAUDE Study
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Sylvie Pons, Sophie Trouillet-Assant, Fabien Subtil, Fatima Abbas-Chorfa, Elise Cornaton, Amélie Berthiot, Sonia Galletti, Aurélie Plat, Stephanie Rapin, Laurene Trapes, Laurence Generenaz, Karen Brengel-Pesce, Arnaud Callies, Franck Plaisant, Olivier Claris, Aurelie Portefaix, Cyril Flamant, and Marine Butin
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late-onset sepsis ,LOS ,neonatal intensive care unit ,NICU ,biomarker ,Biology (General) ,QH301-705.5 - Abstract
Despite the high prevalence of late-onset sepsis (LOS) in neonatal intensive care units, a reliable diagnosis remains difficult. This prospective, multicenter cohort study aimed to identify biomarkers early to rule out the diagnosis of LOS in 230 neonates ≥7 days of life with signs of suspected LOS. Blood levels of eleven protein biomarkers (PCT, IL-10, IL-6, NGAL, IP-10, PTX3, CD14, LBP, IL-27, gelsolin, and calprotectin) were measured. Patients received standard of care blinded to biomarker results, and an independent adjudication committee blinded to biomarker results assigned each patient to either infected, not infected, or unclassified groups. Performances of biomarkers were assessed considering a sensitivity of at least 0.898. The adjudication committee classified 22% of patients as infected and all of these received antibiotics. A total of 27% of the not infected group also received antibiotics. The best biomarkers alone were IL-6, IL-10, and NGAL with an area under the curve (95% confidence interval) of 0.864 (0.798–0.929), 0.845 (0.777–0.914), and 0.829 (0.760–0.898), respectively. The best combinations of up to four biomarkers were PCT/IL-10, PTX3/NGAL, and PTX3/NGAL/gelsolin. The best models of biomarkers could have identified not infected patients early on and avoided up to 64% of unjustified antibiotics. At the onset of clinical suspicion of LOS, additional biomarkers could help the clinician in identifying non-infected patients.
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- 2023
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192. Eleven Years of Health Monitoring in Wild Boars (Sus scrofa) in the Emilia-Romagna Region (Italy)
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Arianna Rossi, Annalisa Santi, Filippo Barsi, Gabriele Casadei, Alessandra Di Donato, Maria Cristina Fontana, Giorgio Galletti, Chiara Anna Garbarino, Annalisa Lombardini, Carmela Musto, Alice Prosperi, Giovanni Pupillo, Gianluca Rugna, and Marco Tamba
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african swine fever ,Aujeszky’s disease ,brucellosis ,classical swine fever ,passive surveillance ,swine influenza ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
In recent years, the growth of wild ungulates has increased the focus on their health monitoring. In particular, the health status of wild boars is relevant for the economic impact on the pig industry. The Emilia-Romagna region activated a wildlife monitoring plan to better evaluate the health status of the wild boar population. Between 2011 and 2021, samples of found dead and hunted wild boar have been examined for trichinellosis, tuberculosis, brucellosis, african swine fever, classical swine fever, Aujeszky’s disease, swine vesicular disease, and swine influenza A. Trichinella britovi was identified in 0.001% of the examined wild boars; neither M. bovis nor M. tuberculosis were found in M. tuberculosis complex positive samples; 2.3% were positive for Brucella suis; 29.4% of the sera were positive for Aujeszky’s disease virus; and 0.9% of the samples were positive for swine influenza A virus. With an uncertain population estimate, the number of animals tested, the number of positives, and the sampling method do not allow us to make many inferences but suggest the need to implement and strengthen the existing surveillance activity, as it seems to be the only viable alternative for safeguarding animal and human health.
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- 2023
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193. Pregnancy in Patients with Moderate and Highly Complex Congenital Heart Disease
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Mario Panebianco, Marco Alfonso Perrone, Maria Giulia Gagliardi, Lorenzo Galletti, and Pier Paolo Bassareo
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congenital heart disease ,pregnancy ,GUCH ,ACHD ,risk stratification ,Medicine - Abstract
Although not completely devoid of risk, pregnancy can be managed in virtually all patients affected by even the most complex forms of congenital heart disease. It is not however advisable in patients with any form of pulmonary arterial hypertension. Pregnancy is even manageable in patients with univentricular heart converted to Fontan circulation. A personalised risk stratification should be performed, and patients affected by advanced NYHA functional class appropriately warned of the potential risks. In this setting, metabolomics might represent a novel tool for use in conducting personalised risk stratification. All pregnancies, particularly those at higher risk, should be managed in a tertiary care centre capable of providing the necessary assistance to both the mother and infant. With a few rare exceptions, vaginal delivery is to be preferred over caesarean section due to the lower degree of maternal and foetal complications. The desire for motherhood, at times extreme in women with congenital heart disease, may often be accomplished, thus providing a ray of hope in the lives of these patients.
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- 2023
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194. Characterization of Early and Late Damage in a Mouse Model of Pelvic Radiation Disease
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Roberta Vitali, Francesca Palone, Ilaria De Stefano, Chiara Fiorente, Flavia Novelli, Emanuela Pasquali, Emiliano Fratini, Mirella Tanori, Simona Leonardi, Barbara Tanno, Eleonora Colantoni, Sara Soldi, Serena Galletti, Maria Grimaldi, Alessio Giuseppe Morganti, Lorenzo Fuccio, Simonetta Pazzaglia, Claudio Pioli, Mariateresa Mancuso, and Loredana Vesci
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mouse model ,intestinal damage ,ionizing radiation ,intestinal stem cells ,fecal markers ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Pelvic radiation disease (PRD), a frequent side effect in patients with abdominal/pelvic cancers treated with radiotherapy, remains an unmet medical need. Currently available preclinical models have limited applications for the investigation of PRD pathogenesis and possible therapeutic strategies. In order to select the most effective irradiation protocol for PRD induction in mice, we evaluated the efficacy of three different locally and fractionated X-ray exposures. Using the selected protocol (10 Gy/day × 4 days), we assessed PRD through tissue (number and length of colon crypts) and molecular (expression of genes involved in oxidative stress, cell damage, inflammation, and stem cell markers) analyses at short (3 h or 3 days after X-ray) and long (38 days after X-rays) post-irradiation times. The results show that a primary damage response in term of apoptosis, inflammation, and surrogate markers of oxidative stress was found, thus determining a consequent impairment of cell crypts differentiation and proliferation as well as a local inflammation and a bacterial translocation to mesenteric lymph nodes after several weeks post-irradiation. Changes were also found in microbiota composition, particularly in the relative abundance of dominant phyla, related families, and in alpha diversity indices, as an indication of dysbiotic conditions induced by irradiation. Fecal markers of intestinal inflammation, measured during the experimental timeline, identified lactoferrin, along with elastase, as useful non-invasive tools to monitor disease progression. Thus, our preclinical model may be useful to develop new therapeutic strategies for PRD treatment.
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- 2023
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195. Representaciones, acceso a la justicia y voz para mujeres de generaciones jóvenes y mayores
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Manuela Graciela González and Hilda Gabriela Galletti
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acceso a la justicia ,violencias ,representaciones sociales ,mujeres de distintas generaciones ,access to justice ,violence ,social representations ,women of different generations ,Social legislation ,K7585-7595 - Abstract
Partimos de las voces de las mujeres que transitan situaciones de violencias, sus representaciones y el acceso a la justicia tomando sus particularidades y dificultades en cada período de la vida. Nos preguntamos: ¿Cómo podemos trabajar mejor juntos/as desde la Sociología Jurídica para abordar estos desafíos interdisciplinariamente? ¿Qué tan diversas deben ser nuestras instituciones de justicia para dar respuesta a las necesidades de las mujeres de distintas generaciones? ¿Cómo se les da voz a las más jóvenes en las decisiones sobre su futuro y en la resolución de sus conflictos? La Administración de justicia brinda o no respuestas a las mujeres, son adecuadas/inadecuadas según el momento evolutivo y los conflictos que viven. Para realizar este abordaje retomaremos los conceptos de gubernamentalidad, cautiverio e interseccionalidad, considerando a las mujeres como sujetos históricos y culturales. We start from the voices of women who go through situations of violence, their representations and access to justice, taking their particularities and difficulties in each period of life. We ask ourselves: How can we work better together from Legal Sociology to address these challenges interdisciplinary? How diverse must our justice institutions be to respond to the needs of women of different generations? How are the youngest girls given a voice in decisions about their future and in resolving their conflicts? The Administration of justice does or does not provide answers to women, they are adequate/inadequate according to the evolutionary moment and the conflicts they experience. To carry out this approach we will return to the concepts of governmentality, captivity and intersectionality, considering women as historical and cultural subjects. Available from: https://doi.org/10.35295/osls.iisl/0000-0000-0000-1174
- Published
- 2021
196. Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage
- Author
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Ada Gjyrezi, Giuseppe Galletti, Jiaren Zhang, Daniel Worroll, Michael Sigouros, Seaho Kim, Victoria Cooley, Karla V. Ballman, Allyson J. Ocean, Manish A. Shah, Joseph M. Scandura, Andrea Sboner, David M. Nanus, Himisha Beltran, Scott Tagawa, and Paraskevi Giannakakou
- Subjects
Biology (General) ,QH301-705.5 - Abstract
Ada Gjyrezi et al. show that ddPCR can be used to accurately measure androgen receptor variant (AR-V) expression levels in single circulating tumor cells (CTCs) from prostate cancer patients. They show that current methods for isolating CTCs tend to underestimate the prevalence of AR-V and that a specific variant, AR-v567es, could be potentially used as a biomarker for an aggressive subtype of prostate cancer.
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- 2021
- Full Text
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197. Evidence of a topological Hall effect in Eu 1� x Sm x TiO 3
- Author
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Ahadi, Kaveh, Galletti, Luca, and Stemmer, Susanne
- Published
- 2017
198. Ductal ligation timing and neonatal outcomes: a 12-year bicentric comparison
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Martini, Silvia, Galletti, Silvia, Kelsall, Wilf, Angeli, Emanuela, Agulli, Marta, Gargiulo, Gaetano Domenico, Chen, Si Emma, Corvaglia, Luigi, and Singh, Yogen
- Published
- 2021
- Full Text
- View/download PDF
199. Floating macrolitter leaked from Europe into the ocean
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González-Fernández, Daniel, Cózar, Andrés, Hanke, Georg, Viejo, Josué, Morales-Caselles, Carmen, Bakiu, Rigers, Barceló, Damià, Bessa, Filipa, Bruge, Antoine, Cabrera, María, Castro-Jiménez, Javier, Constant, Mel, Crosti, Roberto, Galletti, Yuri, Kideys, Ahmet E., Machitadze, Nino, Pereira de Brito, Joana, Pogojeva, Maria, Ratola, Nuno, Rigueira, Júlia, Rojo-Nieto, Elisa, Savenko, Oksana, Schöneich-Argent, Rosanna I., Siedlewicz, Grzegorz, Suaria, Giuseppe, and Tourgeli, Myrto
- Published
- 2021
- Full Text
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200. Zn2+ and Cd2+ removal from wastewater using clinoptilolite as adsorbent
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Galletti, Camilla, Dosa, Melodj, Russo, Nunzio, and Fino, Debora
- Published
- 2021
- Full Text
- View/download PDF
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