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1,158 results on '"Furlan R"'

151. Gene Therapy: a Possible Future Option for MS

Author

MARTINO , GIANVITO, FURLAN R, POLIANI PL, BERGAMI A, DESINA G, COMI G, MARCONI P., Link H., Fredricson S., Martino, Gianvito, Furlan, R, Poliani, Pl, Bergami, A, Desina, G, Comi, G, and Marconi, P.

Published
1999

160. Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study

Author

Kuhle, J, primary, Disanto, G, additional, Dobson, R, additional, Adiutori, R, additional, Bianchi, L, additional, Topping, J, additional, Bestwick, JP, additional, Meier, U-C, additional, Marta, M, additional, Costa, G Dalla, additional, Runia, T, additional, Evdoshenko, E, additional, Lazareva, N, additional, Thouvenot, E, additional, Iaffaldano, P, additional, Direnzo, V, additional, Khademi, M, additional, Piehl, F, additional, Comabella, M, additional, Sombekke, M, additional, Killestein, J, additional, Hegen, H, additional, Rauch, S, additional, D’Alfonso, S, additional, Alvarez-Cermeño, JC, additional, Kleinová, P, additional, Horáková, D, additional, Roesler, R, additional, Lauda, F, additional, Llufriu, S, additional, Avsar, T, additional, Uygunoglu, U, additional, Altintas, A, additional, Saip, S, additional, Menge, T, additional, Rajda, C, additional, Bergamaschi, R, additional, Moll, N, additional, Khalil, M, additional, Marignier, R, additional, Dujmovic, I, additional, Larsson, H, additional, Malmestrom, C, additional, Scarpini, E, additional, Fenoglio, C, additional, Wergeland, S, additional, Laroni, A, additional, Annibali, V, additional, Romano, S, additional, Martínez, AD, additional, Carra, A, additional, Salvetti, M, additional, Uccelli, A, additional, Torkildsen, Ø, additional, Myhr, KM, additional, Galimberti, D, additional, Rejdak, K, additional, Lycke, J, additional, Frederiksen, JL, additional, Drulovic, J, additional, Confavreux, C, additional, Brassat, D, additional, Enzinger, C, additional, Fuchs, S, additional, Bosca, I, additional, Pelletier, J, additional, Picard, C, additional, Colombo, E, additional, Franciotta, D, additional, Derfuss, T, additional, Lindberg, RLP, additional, Yaldizli, Ö, additional, Vécsei, L, additional, Kieseier, BC, additional, Hartung, HP, additional, Villoslada, P, additional, Siva, A, additional, Saiz, A, additional, Tumani, H, additional, Havrdová, E, additional, Villar, LM, additional, Leone, M, additional, Barizzone, N, additional, Deisenhammer, F, additional, Teunissen, C, additional, Montalban, X, additional, Tintoré, M, additional, Olsson, T, additional, Trojano, M, additional, Lehmann, S, additional, Castelnovo, G, additional, Lapin, S, additional, Hintzen, R, additional, Kappos, L, additional, Furlan, R, additional, Martinelli, V, additional, Comi, G, additional, Ramagopalan, SV, additional, and Giovannoni, G, additional

Published
2015
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162. Altered miRNA expression in T regulatory cells in course of multipla sclerosis

Author

DE SANTIS, Giuseppe, Ferracin, Manuela, Biondani, Andrea, Caniatti, Luisa, Tola, Maria Rosaria, Castellazzi, Massimiliano, Zagatti, Barbara, Fainardi, Enrico, Gavioli, Riccardo, Negrini, Massimo, Furlan, R., and Granieri, Enrico Gavino Giuseppe

Subjects
multiple sclerosis, miRNA, regulatory T cells
Published
2010

163. A consensus protocol for the standardisation of cerebrospinal fluid collection and biobanking

Author

Teunissen, CE, Petzold, A, Bennett, JL, Berven, FS, Brundin, L, Comabella, M, Franciotta, D, Federiksen, JL, Fleming, JO, Furlan, R, Hintzen, Rogier, Hughes, SG, Johnson, MH, Krasulova, E, Kuhle, J, Magnone, MC, Rajda, C, Rejdak, K, Schmidt, HK, van Pesch, V, Waubant, E, Wolf, C, Giovannoni, G, Deisenhammer, F, Hegen, H, Hemmer, B, Tumani, HT, Molecular cell biology and Immunology, Neurology, and NCA - Multiple Sclerosis and Other Neuroinflammatory Diseases

Abstract

There is a long history of research on body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only very few biomarkers in cerebrospinal fluid (CSF) are being used in clinical practice. One of the most critical factors in CSF biomarker research is the inadequate powering of Studies owing to the lack of sufficient samples that call be obtained in sin-le-centre studies. Therefore, collaboration between investigators is needed to establish lame biobanks of well-defined samples. Standardised protocols for biobanking are a prerequisite to ensure that the statistical power gained by increasing the numbers of CSF samples is not compromised by preanalytical factors. Here. a consensus report on guidelines of CSF collection and biobanking is presented. formed by the European network for Biomarkers in MS for CSF biomarker research in Multiple sclerosis. In this paper, we FOCUS on CSF collection procedures, preanalytical factors, and high quality clinical and paraclinical information. The biobanking protocols are applicable for CSF biobanks For research targeting any neurological disease.

Published
2010

166. Syncope recurrence and mortality: a systematic review

Author

Solbiati, M., primary, Casazza, G., additional, Dipaola, F., additional, Rusconi, A. M., additional, Cernuschi, G., additional, Barbic, F., additional, Montano, N., additional, Sheldon, R. S., additional, Furlan, R., additional, and Costantino, G., additional

Published
2014
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172. A new management of syncope: prospective systematic guideline-based evaluation of patients referred urgently to general hospitals

Author

Brignole, M, Menozzi, C, Bartoletti, A, Giada, F, Lagi, A, Ungar, A, Ponassi, I, Mussi, C, Maggi, R, Re, G, Furlan, R, Rovelli, G, Ponzi, P, Scivales, A, Ammirati, F., Bagnoli, L., Baldi, G., Borella, M., Casagranda, I., Cencetti, S., Colombo, S., Cortelli, P., Dassi, S., De Ceglia, S., Del Greco, M., Del Rosso, A., Dell’Orto, S., Demarchi, P. G., di Leo, R., Disertori, M., Durin, O., Fabiani, P., Ferrari, F., Foffa, A., Foglia Manzillo, G., Gargano, U., Grifoni, S., Iori, I., Locati, F., Lunati, M., Marenco, M., Masotti, G., Mathieu, G., Miceli, G., Moro, C., Noro, G., Occhetta, E., Perdetti, S., Poggi, A., Quartieri, F., Raviele, A., Ribani, M. A., Saggese, P. M., Salvioli, G., Sandrone, G., Tava, G., Vado, A., Vecchi, R., Vicari, F., Vincenti, A., and Vita, Giuseppe

Published
2006

173. Effect of priming with diphtheria and tetanus toxoids combined with whole-cell pertussis vaccine or with acellular pertussis vaccine on the safety and immunogenicity of a booster dose of an acellular pertussis vaccine containing a genetically inactivated pertussis toxin in fifteen- to twenty-one-month-old children. Italian Multicenter Group for the Study of Recombinant Acellular Pertussis Vaccine

Author

Podda, A., Bona, G., Canciani, G., Pistilli, A., Contu, B., Furlan, R., Meloni, T., Stramare, D., Titone, L., Rappuoli, R., Granoff, D., Bartalini, M., Budroni, M., Deluca, E., Antonio Cascio, Cascio, G., Cossu, M., Orto, P., Dileo, G., Dipisa, F., Furlan, A., Macagno, F., Marsili, I., Maida, A., Meloni, G., Moiraghi, A., Nencioni, L., Peppoloni, S., Regoli, D., Rigo, G., Trappan, A., Uxa, F., Vargiu, G., Volpini, G., PODDA A, BONA G, CANCIANI G, PISTILLI AMC, CONTU B, FURLAN R, MELONI T, STRAMARE D, TITONE L, RAPPUOLI R, GRANOFF DM, BARTALINI M, BUDRONI M, DELUCA EC, CASCIO A, CASCIO G, COSSU M, ORTO PD, DILEO G, DIPISA F, FURLAN A, MACAGNO F, MARSILI I, MAIDA A, MELONI G, MOIRAGHI A, NENCIONI L, PEPPOLONI S, REGOLI D, RIGO G, TRAPPAN A, UXA F, VARGIU G, and VOLPINI G

Subjects
Time Factors, Whooping Cough, Immunization, Secondary, Enzyme-Linked Immunosorbent Assay, Booster dose, complex mixtures, Bordetella pertussis, Double-Blind Method, medicine, Humans, Virulence Factors, Bordetella, Diphtheria-Tetanus-Pertussis Vaccine, Whooping cough, Pertussis Vaccine, Vaccines, Synthetic, Tetanus, business.industry, Diphtheria, Toxoid, Antibody titer, Infant, medicine.disease, Antibodies, Bacterial, Virology, VACCINE, pertussis, Vaccination, Pertussis Toxin, Pediatrics, Perinatology and Child Health, Immunology, Pertussis vaccine, business, Follow-Up Studies, medicine.drug
Abstract

Objective: To evaluate the safety and the immunogenicity of a booster dose of recombinant acellular pertussis vaccine combined with diphtheria and tetanus toxoids (DTaP, Biocine SpA) in 15- to 21-month-old children primed in infancy with either whole-cell diphtheria-tetanus-pertussis (DTwP) vaccine or DTaP vaccine. Design: Open-label second phase of a double-masked, controlled trail, with masked analysis of serum samples. Participants and setting: Three hundred fifty children, 15 to 21 months of age, who had been primed at 2, 4, and 6 months of age with either three doses of DTaP vaccine (n = 173) or DTwP vaccine (n = 177). The children were enrolled in eight vaccination centers in Italy. Interventions: All children received a booster dose of the DTaP vaccine and were examined for safety at 48 hours and at 7 days after vaccination. Serum samples for evaluation of immunogenicity were obtained from 196 (55%) of the 350 children. Main outcome measures: IgG antibodies to pertussis toxin (Ptox), filamentous hemagglutinin, 69-kilodalton protein, and tetanus toxoid were measured by enzyme-linked immunosorbent assay. Pertussis toxin-neutralizing antibodies were measured by the Chinese hamster ovary cell toxin neutralization assay. Main results: Adverse reactions to DTaP were infrequent, and there was no difference in the incidence of local or systemic reactions in children given DTaP as a fourth dose in comparison with a first dose. One month after the DTaP booster vaccination, both groups had 6- to 40-fold increases in serum antibody concentrations to all antigens tested; the concentrations against the three pertussis antigens were higher in the DTaP-primed children (p

Published
1995

174. Comparative study of a whole-cell pertussis vaccine and a recombinant acellular pertussis vaccine

Author

PODDA A, DELUCA EC, CONTU B, FURLAN R, MAIDA A, MOIRAGHI A, STRAMARE D, TITONE L, UXA F, DIPISA F, PEPPOLONI S, NENCIONI L, RAPPUOLI R, BARTALINI M, BONA G, BUDRONI M, PISTILLI AMC, CASCIO A, CASCIO G, COSSU M, DALLORTO P, DILEO G, FURLAN A, MACAGNO F, MARSILI I, MELONI T, REGOLI D, RIGO G, TRAPPAN A, VARGIU G, VOLPINI G, PODDA A, DELUCA EC, CONTU B, FURLAN R, MAIDA A, MOIRAGHI A, STRAMARE D, TITONE L, UXA F, DIPISA F, PEPPOLONI S, NENCIONI L, RAPPUOLI R, BARTALINI M, BONA G, BUDRONI M, PISTILLI AMC, CASCIO A, CASCIO G, COSSU M, DALLORTO P, DILEO G, FURLAN A, MACAGNO F, MARSILI I, MELONI T, REGOLI D, RIGO G, TRAPPAN A, VARGIU G, and VOLPINI G

Subjects
Bordetella pertussis, biology, business.industry, Diphtheria, Filamentous haemagglutinin adhesin, biology.organism_classification, medicine.disease, Pertussis toxin, complex mixtures, Virology, Vaccination, Vaccino pertosse, immunogenicità, tossina, vaccinazione, bambini, Pediatrics, Perinatology and Child Health, Immunology, medicine, Pertussis vaccine, Pertactin, BORDETELLA-PERTUSSIS, business, Whooping cough, medicine.drug
Abstract

The safety and immunogenicity of an acellular pertussis vaccine containing the genetically detoxified pertussis toxin PT-9K/129C, filamentous hemagglutinin, and pertactin, together with diphtheria and tetanus toxoids, were compared with those of a whole-cell pertussis component-diphtheria-tetanus vaccine. Four hundred eighty infants were enrolled into this prospective, multicenter, double-blind study. Each infant was randomly given three doses of one of the two vaccines at 2, 4, and 6 months of age. Both local and systemic adverse reactions, reported within 48 hours and 7 days of each injection, were less frequent after the acellular vaccine than after the whole-cell vaccine. The enzyme-linked immunosorbent assay titers to pertussis toxin, filamentous hemagglutinin, and pertactin, as well as the pertussis toxin-neutralizing titer measured by the Chinese hamster ovary cell assay, were significantly higher after the acellular vaccine was given. Both vaccines induced adequate levels of anti-diphtheria and anti-tetanus antibodies. We conclude that the recombinant acellular pertussis vaccine produces fewer reactions than the whole-cell vaccine and provides a high antibody response against the antigens of Bordetella pertussis involved in bacterial adhesion and systemic toxic effects.

Published
1994

175. HTLV-I HU-SCID MOUSE IN THE STUDY OF HTLV-I NEUROTROPISM

Author

FURLAN R, SALAZARGRUESO EF, LILLO F, KOTULSKI M, BRAMBILLA E, CASTELLANO M, TERRENI MR, ROOS RP, GRIMALDI LME, MARTINO , GIANVITO, Furlan, R, Salazargrueso, Ef, Martino, Gianvito, Lillo, F, Kotulski, M, Brambilla, E, Castellano, M, Terreni, Mr, Roos, Rp, and Grimaldi, Lme

Published
1994

183. Induction of fetal lung maturation in the prevention of hyaline membrane disease: the connection with neonatal sepsis

Author

Lorenza DRIUL, Furlan R, Macagno F, Pezzani I, Plaino L, Ianni A, Casarsa S, Zavarise D, and Marchesoni D

Subjects
Adult, Male, Fetal Membranes, Premature Rupture, Respiratory Distress Syndrome, Newborn, Hyaline Membrane Disease, Incidence, Infant, Newborn, Gestational Age, Infant, Low Birth Weight, Betamethasone, Dexamethasone, Anti-Bacterial Agents, Fetal Organ Maturity, Italy, Pregnancy, Prenatal Exposure Delayed Effects, Sepsis, Birth Weight, Humans, Female, Disease Susceptibility, Lung, Infant, Premature, Cerebral Hemorrhage
Abstract

The aim of this study was to evaluate the effect of antenatal maternal corticosteroid treatment on the frequency of neonatal outcomes and perinatal infectious morbidity among singleton pregnancies complicated by preterm delivery.A nonrandomized analysis was performed on 189 neonates of 24-34 weeks' gestation who were born at the Department of Obstetrics and Gynecology, University of Udine, between January 2000 to December 2001. The neonates were subdivided into 3 groups: 1) 143 neonates received 2 doses of corticosteroids in a 24-hour interval and repeated after 10 days; 2) 26 neonates received 2 doses; 3) 20 neonates did not receive any treatment. Data were analysed with the Fisher exact test. p0.05 was considered significant.The incidence of respiratory distress syndrome (RDS), neonatal mortality and intraventricular hemorrhage was respectively 43.4%, 3.2 % and 6.3 %. The rate of early-onset neonatal sepsis was 4.9% in the 1st group, 3.9% in the 2nd group and 5% in the 3rd group. There were no significant differences in the early-onset neonatal sepsis and the antenatal corticosteroids treatment.The single or the multiple courses of antenatal steroids did not apparently increase neonatal sepsis in patients with preterm delivery.

Published
2003

185. Suspension trauma and tilt-table test syncope: the same and the different

Author

Lanfranconi, F, Barbic, F, Pollastri, L, Bartesaghi, M, Corna, G, Furlan, R, Miserocchi, G, LANFRANCONI, FRANCESCA, MISEROCCHI, GIUSEPPE ANDREA, Lanfranconi, F, Barbic, F, Pollastri, L, Bartesaghi, M, Corna, G, Furlan, R, Miserocchi, G, LANFRANCONI, FRANCESCA, and MISEROCCHI, GIUSEPPE ANDREA

Published
2013

192. A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking.

Author

UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service de neurologie, UCL - MD/MNOP - Département de morphologie normale et pathologique, Teunissen, C E, Petzold, A, Bennett, J L, Berven, F S, Brundin, L, Comabella, M, Franciotta, D, Frederiksen, J L, Fleming, J O, Furlan, R, Hintzen, R Q, Hughes, S G, Johnson, M H, Krasulova, E, Kuhle, J, Magnone, M C, Rajda, C, Rejdak, K, Schmidt, H K, Van Pesch, Vincent, Waubant, E, Wolf, C, Giovannoni, G, Hemmer, B, Tumani, H, Deisenhammer, F, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service de neurologie, UCL - MD/MNOP - Département de morphologie normale et pathologique, Teunissen, C E, Petzold, A, Bennett, J L, Berven, F S, Brundin, L, Comabella, M, Franciotta, D, Frederiksen, J L, Fleming, J O, Furlan, R, Hintzen, R Q, Hughes, S G, Johnson, M H, Krasulova, E, Kuhle, J, Magnone, M C, Rajda, C, Rejdak, K, Schmidt, H K, Van Pesch, Vincent, Waubant, E, Wolf, C, Giovannoni, G, Hemmer, B, Tumani, H, and Deisenhammer, F

Abstract

There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in CSF are being used in clinical practice. One of the most critical factors in CSF biomarker research is the inadequate powering of studies because of the lack of sufficient samples that can be obtained in single-center studies. Therefore, collaboration between investigators is needed to establish large biobanks of well-defined samples. Standardized protocols for biobanking are a prerequisite to ensure that the statistical power gained by increasing the numbers of CSF samples is not compromised by preanalytical factors. Here, a consensus report on recommendations for CSF collection and biobanking is presented, formed by the BioMS-eu network for CSF biomarker research in multiple sclerosis. We focus on CSF collection procedures, preanalytical factors, and high-quality clinical and paraclinical information. The biobanking protocols are applicable for CSF biobanks for research targeting any neurologic disease.

Published
2009

193. A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking

Author

Teunissen, C E, Petzold, A, Bennett, J L, Berven, F S, Brundin, L, Comabella, M, Franciotta, D, Frederiksen, J L, Fleming, J O, Furlan, R, Hintzen, R Q, Hughes, S G, Johnson, M H, Krasulova, E, Kuhle, J, Magnone, M C, Rajda, C, Rejdak, K, Schmidt, H K, van Pesch, V, Waubant, E, Wolf, C, Giovannoni, G, Hemmer, B, Tumani, H, Deisenhammer, F, Teunissen, C E, Petzold, A, Bennett, J L, Berven, F S, Brundin, L, Comabella, M, Franciotta, D, Frederiksen, J L, Fleming, J O, Furlan, R, Hintzen, R Q, Hughes, S G, Johnson, M H, Krasulova, E, Kuhle, J, Magnone, M C, Rajda, C, Rejdak, K, Schmidt, H K, van Pesch, V, Waubant, E, Wolf, C, Giovannoni, G, Hemmer, B, Tumani, H, and Deisenhammer, F

Abstract

Udgivelsesdato: 2009-Dec, There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in CSF are being used in clinical practice. One of the most critical factors in CSF biomarker research is the inadequate powering of studies because of the lack of sufficient samples that can be obtained in single-center studies. Therefore, collaboration between investigators is needed to establish large biobanks of well-defined samples. Standardized protocols for biobanking are a prerequisite to ensure that the statistical power gained by increasing the numbers of CSF samples is not compromised by preanalytical factors. Here, a consensus report on recommendations for CSF collection and biobanking is presented, formed by the BioMS-eu network for CSF biomarker research in multiple sclerosis. We focus on CSF collection procedures, preanalytical factors, and high-quality clinical and paraclinical information. The biobanking protocols are applicable for CSF biobanks for research targeting any neurologic disease.

Published
2009

196. Abnormal NMDA receptor function exacerbates experimental autoimmune encephalomyelitis

Author

Grasselli, G, primary, Rossi, S, additional, Musella, A, additional, Gentile, A, additional, Loizzo, S, additional, Muzio, L, additional, Di Sanza, C, additional, Errico, F, additional, Musumeci, G, additional, Haji, N, additional, Fresegna, D, additional, Sepman, H, additional, De Chiara, V, additional, Furlan, R, additional, Martino, G, additional, Usiello, A, additional, Mandolesi, G, additional, and Centonze, D, additional

Published
2012
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197. Short-term complexity indexes of heart period and systolic arterial pressure variabilities provide complementary information

Author

Porta, A., primary, Castiglioni, P., additional, Rienzo, M. Di, additional, Bari, V., additional, Bassani, T., additional, Marchi, A., additional, Takahashi, A. C. M., additional, Tobaldini, E., additional, Montano, N., additional, Catai, A. M., additional, Barbic, F., additional, Furlan, R., additional, Cividjian, A., additional, and Quintin, L., additional

Published
2012
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