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BiblioSpec is a software package for creating and searching libraries of tandem MS peptide spectra. Library searching provides a quick method for making peptide‐spectrum matches by comparing a query spectrum to a collection of reference spectra of known peptide sequence. Pre‐assembled libraries for several model organisms can be used as the basis of a search or custom libraries can easily be assembled. The protocols in this unit describe installing BiblioSpec, searching libraries, and creating custom libraries. Curr. Protoc. Bioinform. 20:13.7.1‐13.7.12. © 2007 by John Wiley & Sons, Inc.

Exogenous surfactant administration is currently being tested in patients with the acute respiratory distress syndrome (ARDS). The results of the studies have varied because several factors may influence the host’s response to this therapy. This clinical pilot study was designed to evaluate the safety and efficacy of exogenous surfactant administration in pediatric patients with ARDS. Surfactant was administered to 13 patients with severe lung dysfunction, and eight of these patients experienced a significant improvement in oxygenation after the first dose of surfactant. In these patients the exogenous surfactant was administered within 48 h of the diagnosis of ARDS, whereas in the five patients who did not respond, surfactant was administered several days after the onset of ARDS. Responders also spent fewer days on a mechanical ventilator and less time in intensive care compared with nonresponders. Based on the results of this pilot study, a more appropriate multicentre clinical trial should be designed to evaluate this treatment strategy.

Opinion. Presents a satire view of the relationship between United States President Bill Clinton and former White House intern, Monica Lewinsky, comparing it to unsynchronized swimming. Why people should not pursue this type of relationship; Consequences of this type of relationship.

Opinion. Comments on a lesbian short story competition which the author entered. Stipulation of the competition; What was not define on the entry form for the competition; Argument the author was prepared to present; Details on the action the author planned to take if his story was rejected.

Opinion. Comments on various developments in New Zealand. Reference to the visit of the United States Secretary of State Madelaine Albright to New Zealand; Reference to country's defeat in rugby by the Boks team of Australia; Discussion on the plans of the city council in Wellington to sell its share in the airport.

Comments that the New Zealand government seems to have reverted to `Think Big spending habits.' Opinion of senior people in positions of responsibility that there is an inverse relationship between the price of advice and its quality; Concerns of the Group of Senior People in Positions of Responsibility (SPiPoR) about expenditure.

Focuses on the fictitious character Zorro, while highlighting various persons who attracted media coverage in New Zealand. Details on the media attention that Zorro received; Identification of various motion pictures Zorro has performed in; Information on the recapture of Anthony Hutton, a escape prisoner; Why Neil Roberts, a rebel, purchased two mig jet fighters.

Opinion. Comments on government spending in New Zealand. Information on Sir Ronald Trotter's announcement of his retirement; Author's views on the New Zealand Treasury; Reference to the failure of the country's infrastructure.

Opinion. Presents information on the minutes of an emergency meeting of the Central Fundraising Committee (CFC), which was held on Tuesday July 8, 1998. Location of the meeting; Emphasis on the issue of the circumstances in which members of the CFC found themselves in light of the Asian financial crisis; Why the CFC was called emergency meeting.

Focuses on public spending in New Zealand. Cost of economic and financial policy and planning in 1984; Figures for the management of commercial liabilities; Details on cost for staff members in the Prime Minister's Department.

Opinion. Comments on the social conditions in New Zealand. Efforts of Prime Minister Jenny Shipley to restructure the economy; Information on politicians.

Comments on the economic status of New Zealand. Problems the author encountered while travelling overseas on the New Zealand dollar; Details on New Zealand's economy; How New Zealand can improve its economic status.

Opinion. Comments on World Cup soccer competition playing in France. Number of teams in the competition; Eruption of riots in France; Sponsors of the competition; Reference to ticket sales.

Opinion. Examines the news article published in `Private Eye' regarding Paul Johnson, historian and columnist. Reference to lead stories on Sky News television network entitled `Spice Girl Splits' and `Gazza Axed--A Nation Mourns'; Johnson's views on family matters; Statements made by Johnson's mistress Gloria Stewart on their 11-year affair.

Presents an anecdote concerning the debate over a 1998 budget bill in Auckland, New Zealand. Reference to the defeat of bill; Importance of defence in debating; Tactics used in the debate.

Editorial. Gives anecdotes relating to several issues in New Zealand, focusing on New Zealand's economic status. Commentary of New Zealand that it has been declared economically dead; By whom the declaration was made.

Reports that the government of New Zealand may be forced to spend approximately $40 million in 1998 on broadcasting Maori radio and television programmes. Allocation of the $40 million; Details on government's plans; Information on Maori television programs. INSET: Privates hit funding.

States that the New Zealand government decided not to sell half of its television company, TVNZ, and is looking for a price for its entire television company. Potential for turning TV One into RNZ-with-pictures; Whether the government will remain in commercial television; What the commercial-free nights in the 1980s illustrates; Response of politicians to the TVNZ's withdrawal from cricket.

Opinion. Addresses the issue of implementating consultants to advice the public of New Zealand on ways of preventing fires. Estimated amount of time spent by by firemen fighting fires; Views of Jack Elder, minister of internal affairs; Experience of the author as a trainee consultant commissioner.

Presents information on a meeting which was supposed to be held at the Karori Yacht Club. Information on the construction of a lounge for executive chairmen; Why the meeting was eventually called off.

Opinion. Comments on the review of strategies and processes of Antishagger International Limited by its board of directors. What issues were covered by the review; Perspective of the chairman about the review.

Reports that there has been a failure in releasing the terms of reference of the Treasury's Television New Zealand (TVNZ) study, based on a fault in the Official Information Act. When the terms of the reference in observing the study of Crown's ownership of TVNZ were requested; Purpose for requesting the terms of reference; When the study is expected to be completed.

Presents information on various issues which had ironic outcomes, making direct reference to the Dominion billboard, which contained a racial slur. Reference to an incident in which a racial slur was made; Omission of the slur by Dominion; Information relating to drug users in New Zealand; Brief details on other issues.

States that information on the terms of reference of the scoping study of the Crown's ownership interest in Television New Zealand was with-held. Why the terms of reference was written; Comments from finance minister Bill Birch.

Editorial. Suggests that in order to deal with social problems, it will be necessary to have a dictatorship in New Zealand. Why it is unrealistic to try to please everyone; Reference to the reaction to the proposed Code of Social Responsibility; Discussion on democracy.

Opinion. Discusses the financial problems Shaun Brown of the New Zealand television station TV1 is facing, while highlighting a documentary on the boat `Titanic.' Estimated amount of money spent to produce a full-size replica of the Titanic; Information on the 1912 Titanic; How this Titanic will be different from the previous one.

Opinion. Comments on claims made by the executive director of Business Roundtable, Roger Kerr, in connection to response from other serious commentators to a remark made by leading industrialist, Hugh Fletcher. Views from Fletcher about `Business Roundtable'; Reference to comments made by Kerr to the Aorangi Club in Auckland in 1994.

Reports on the return of the television series `Frontline' to New Zealand television channels. Details on the dedication of the first episodes of the series in 1995; Details on the characters of the show; Information on the show.

Offers the author's views as they relate to Mum, or Seps, who played the sistrum in the Akmin temple band. Information on the characters of the band; Details on Mum; How the author perceives Seps.

Opinion. Comments on the way newspapers kept publishing pictures of Durex Madonna in a condom on show at Te Papa in New Zealand. Details on the protest against the sculpture; Information on the controversy surrounded by this sculpture.

Presents the dialogue of an interview between White House volunteer Kathleen Willey and reporter Ed Bradley of the television news show `60 Minutes,' concerning United States President Bill Clinton's sex scandal.

Opinion. Focuses on the author's criticism of Pope John Paul II, Rupert Murdoch and Tau Henare, New Zealand's Maori's affairs minister. Why the author has criticised these persons; Reference made to communication with God; Decline in the quality of New Zealand newspapers; Suggestion that the pope has to work on the cardinals who elected him in a similar sort of democratic process.

Opinion. Provides information pertaining to energy in New Zealand focusing on the draft of a document to covering all issues of concern pertaining to energy. Who will be responsible for the preparation of the document; How the document will be drafted; Details on who will perform the assessment of the initial expressions of interest.

Reports that the parliamentary press gallery in New Zealand, has changed its policy of financial independence for its social activities. When the policy was introduced and when it ended; Information on a change in leadership at the organization; Details on elections at the organization's general meeting.

Opinion. Comments on the electric power failure which occurred in Auckland's, New Zealand, central business district in 1998. Author's comments on reactions to Auckland's misfortune; Reference to basic services which are operated in all communities.

Focuses on reverse psychology highlighting what the crowd at the Basin Reserve did regarding the throwing of objects at cricket players. Information on the principles of reverse psychology; What detective inspector, Quentin Doig noticed at the event.

Highlights Waitangi Day in New Zealand, with emphasis on the apologies that took place on national television. Who made the apologies; What the apologies were for.